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https://www.readbyqxmd.com/read/28109087/cd103-cell-growth-factor-flt3l-enhances-the-efficacy-of-immune-checkpoint-blockades-in-murine-glioblastoma-model
#1
Xiaolin Miao, Yiqi Chen, Ke Hao, Meiqin Zheng, Bingyu Chen, Kaiqiang Li, Ying Wang, Wei Zhang, Yu Zhang, Xiaozhou Mou, Shanshan Jiang, Zhen Wang
Glioblastoma is a lethal disease featured with a high proliferation of tumor cells, excessive angiogenesis, and heavydrug resistance. The overall survival of glioblastoma patients was dismal even with intensive standard care. Recent advantages in immune checkpoint blockades are changing the treatment of cancers. However, the efficacy of immune checkpoint blockades in glioblastoma were unclear. Here, we investigated the roles of CD103<sup>+</sup> cells in regulating the effects of immune checkpoint blockades in glioblastoma mouse models...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28107959/use-of-quantum-dot-beads-labeled-monoclonal-antibody-to-improve-the-sensitivity-of-a-quantitative-and-simultaneous-immunochromatographic-assay-for-neuron-specific-enolase-and-carcinoembryonic-antigen
#2
Kun Xiao, Kan Wang, Weijian Qin, Yafei Hou, Wenting Lu, Hao Xu, Yan Wo, Daxiang Cui
Detection of multiplex tumor markers was of great importance for cancer diagnosis. Immunochromatographic test strip (ICTS) was the most frequently-used point-of-care detection means. Herein, a convenient and fast method for simultaneous quantitative detection of neuron specific enolase (NSE) and carcinoembryonic antigen (CEA) was developed based on ICTS using quantum dot beads (QBs) as marking material. Good monodispersity, high colloidal stability and carboxyl-modified (COOH-) QBs were used. For this method, two test lines were applied to the NC membrane for simultaneous analysis of CEA and NSE respectively...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107491/association-of-in-hospital-mortality-and-dysglycemia-in-septic-patients
#3
Hsiao-Yun Chao, Peng-Hui Liu, Shen-Che Lin, Chun-Kuei Chen, Jih-Chang Chen, Yi-Lin Chan, Chin-Chieh Wu, Gerald N Blaney, Zhen-Ying Liu, Cho-Ju Wu, Kuan-Fu Chen
BACKGROUND: The associations between dysglycemia and mortality in septic patients with and without diabetes are yet to be confirmed. Our aim was to analyze the association of diabetes and sepsis mortality, and to examine how dysglycemia (hyperglycemia, hypoglycemia and glucose variability) affects in-hospital mortality of patients with suspected sepsis in emergency department (ED) and intensive care units. METHODS: Clinically suspected septic patients admitted to ED were included, and stratified into subgroups according to in-hospital mortality and the presence of diabetes...
2017: PloS One
https://www.readbyqxmd.com/read/28107402/risk-factors-for-postoperative-pain-intensity-in-patients-undergoing-lumbar-disc-surgery-a-systematic-review
#4
Marie Dorow, Margrit Löbner, Janine Stein, Alexander Konnopka, Hans J Meisel, Lutz Günther, Jürgen Meixensberger, Katarina Stengler, Hans-Helmut König, Steffi G Riedel-Heller
OBJECTIVES: Pain relief has been shown to be the most frequently reported goal by patients undergoing lumbar disc surgery. There is a lack of systematic research investigating the course of postsurgical pain intensity and factors associated with postsurgical pain. This systematic review focuses on pain, the most prevalent symptom of a herniated disc as the primary outcome parameter. The aims of this review were (1) to examine how pain intensity changes over time in patients undergoing surgery for a lumbar herniated disc and (2) to identify socio-demographic, medical, occupational and psychological factors associated with pain intensity...
2017: PloS One
https://www.readbyqxmd.com/read/28105408/predictors-of-prolonged-mechanical-ventilation-in-pediatric-patients-after-cardiac-surgery-for-congenital-heart-disease
#5
Avisa Tabib, Seyed Ehsan Abrishami, Mohammad Mahdavi, Hojjat Mortezaeian, Ziae Totonchi
BACKGROUND: The duration of mechanical ventilation (MV) is one of the most important clinical factors which predict outcomes in pediatric cardiac surgery. The prolonged mechanical ventilation (PMV) following cardiac surgery is a multifactorial phenomenon and there are conflicts regarding its predictors in pediatric population between different centers. OBJECTIVES: The current study aimed to describe PMV predictors in patients undergoing cardiac surgery for congenital heart disease in a tertiary center for pediatric cardiovascular diseases in Iran...
August 2016: Research in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28101156/clinical-and-microbiological-profile-of-babies-born-with-risk-of-neonatal-sepsis
#6
Bin Zhou, Xiao Liu, Jie-Bin Wu, Bao Jin, Yan-Yan Zhang
The aim of the present study was to evaluate the effects of antibiotics on the condition of babies born with risk of neonatal sepsis. From March, 2014 to February, 2015, 200 neonates born with risk factors of septicemia in the Neonatal Intensive Care Unit at Xuzhou Central Hospital, were enrolled in the present study. Venous blood samples were collected within 6 h of birth using aseptic technique. Part of the blood specimens were cultured using BACTEC PEDS PLUS/F Culture Vials. Subsequently, the subcultures were prepared from each presumptive positive vial and bacterial isolates were identified...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28100012/characterization-and-management-of-patients-with-heroin-versus-non-heroin-opioid-overdoses-experience-at-an-academic-medical-center
#7
Kate M Morizio, Regan A Baum, Adam Dugan, Julia E Marin, Abby M Bailey
STUDY OBJECTIVES: To characterize the differences between patients who had heroin and non-heroin opioid overdoses and to determine whether there were any significant differences in their management with regard to the naloxone use. DESIGN: Retrospective cohort study. SETTING: Large, academic medical center. PATIENTS: A total of 923 patients admitted to the medical center who were identified for overdose by heroin or other opiate-related narcotics between January 2010 and September 2015; 480 patients experienced a non-heroin opioid overdose event, and 443 patients experienced a heroin overdose event...
January 18, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28098920/-too-long-in-tbs-a-study-on-patients-receiving-forensic-psychiatric-tbs-treatment-for-15-years-or-longer
#8
H Nijman, S Lammers, M Vrinten, E Bulten
In 2013 in the Netherlands about 100 forensic psychiatric patients were treated in tbs-hospitals for 15 years or more.<br/> AIM: To investigate the variables that characterise patients who have been receiving forensic psychiatric treatment (tbs) for 15 years or more, and to obtain insight in which actions might be helpful to facilitate discharge or transfer of such patients to other (mental health care) facilities, according to their caregivers and experts.<br/> METHOD: The group of long-term tbs-patients (n = 97) was compared with regard to diagnostic characteristics, 'basic historical risks' (as assessed by risk assessment instruments), and behaviour  to three other groups of forensic patients: a...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/28098590/analgesia-and-sedation-requirements-in-mechanically-ventilated-trauma-patients-with-acute-preinjury-use-of-cocaine-and-or-amphetamines
#9
Bridgette Kram, Shawn J Kram, Michelle L Sharpe, Michael L James, Maragatha Kuchibhatla, Mark L Shapiro
BACKGROUND: The purpose of this study was to determine whether mechanically ventilated trauma patients with a positive urine drug screen (UDS) for cocaine and/or amphetamines have different opioid analgesic and sedative requirements compared with similar patients with a negative drug screen for these stimulants. METHODS: This retrospective, single-center cohort study at a tertiary care, academic medical and level 1 trauma center in the United States included patients ≥16 years of age who were admitted to an adult intensive care unit with a diagnosis of trauma between 2009 and 2013 with a UDS documented within 24 hours of admission, and were mechanically ventilated for >24 hours...
January 16, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28097694/serial-cytokine-alterations-and-abnormal-neuroimaging-in-newborn-infants-with-encephalopathy
#10
Fiona M O'Hare, R William G Watson, Amanda O'Neill, Ricardo Segurado, Deirdre Sweetman, Paul Downey, Eoghan Mooney, John Murphy, Veronica Donoghue, Eleanor J Molloy
AIM: Inflammatory cytokines may play a role in the final common pathway in the pathogenesis of hypoxic-ischaemic injury in experimental models. We aimed to profile the systemic pro- and anti-inflammatory response over the first week of life in term infants at risk of neonatal encephalopathy. METHOD: In a tertiary referral university neonatal intensive care unit, serial blood samples were analysed from 41 term infants (requiring resuscitation at birth) in this prospective observational pilot study...
January 17, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28097438/attitudes-towards-fever-amongst-uk-paediatric-intensive-care-staff
#11
Thomas Brick, Rachel S Agbeko, Patrick Davies, Peter J Davis, Akash Deep, Peter-Marc Fortune, David P Inwald, Amy Jones, Richard Levin, Kevin P Morris, John Pappachan, Samiran Ray, Shane M Tibby, Lyvonne N Tume, Mark J Peters
: The role played by fever in the outcome of critical illness in children is unclear. This survey of medical and nursing staff in 35 paediatric intensive care units and transport teams in the United Kingdom and Ireland established attitudes towards the management of children with fever. Four hundred sixty-two medical and nursing staff responded to a web-based survey request. Respondents answered eight questions regarding thresholds for temperature control in usual clinical practice, indications for paracetamol use, and readiness to participate in a clinical trial of permissive temperature control...
January 18, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28095838/communication-with-families-regarding-organ-and-tissue-donation-after-death-in-intensive-care-comfort-protocol-for-an-intervention-study
#12
Julie E Potter, Robert G Herkes, Lin Perry, Rosalind M Elliott, Anders Aneman, Jorge L Brieva, Elena Cavazzoni, Andrew T H Cheng, Michael J O'Leary, Ian M Seppelt, Val Gebski
BACKGROUND: Discussing deceased organ donation can be difficult not only for families but for health professionals who initiate and manage the conversations. It is well recognised that the methods of communication and communication skills of health professionals are key influences on decisions made by families regarding organ donation. METHODS: This multicentre study is being performed in nine intensive care units with follow-up conducted by the Organ and Tissue Donation Service in New South Wales (NSW) Australia...
January 17, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28094484/a-simplified-screening-tool-to-identify-seriously-ill-patients-in-the-emergency-department-for-referral-to-a-palliative-care-team
#13
Paolo Cotogni, Anna DE Luca, Andrea Evangelista, Claudia Filippini, Renata Gili, Antonio Scarmozzino, Giovannino Ciccone, Luca Brazzi
BACKGROUND: The aims of this study were to evaluate the feasibility of an Emergency Department (ED)-initiated screening to identify seriously ill patients in need of palliative care (PC) and to develop a simplified screening tool (SST). METHODS: Eligible patients with known diagnosis of chronic heart, lung, liver, and kidney failures, progressive neurological diseases or advanced cancer, awaiting to be hospitalized after an ED-visit, were assessed with the screening tool from the Italian Society Anaesthesia Analgesia Resuscitation Intensive Care (SIAARTI)...
January 17, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28094211/likelihood-of-unacceptable-normal-tissue-doses-in-breast-cancer-patients-undergoing-regional-nodal-irradiation-in-routine-clinical-practice
#14
Jose Bazan, Dominic DiCostanzo, Karla Kuhn, Lonika Majithia, Allison Quick, Nilendu Gupta, Julia White
PURPOSE: As indications for regional nodal irradiation (RNI) for breast cancer have expanded, so too has scrutiny over potential late toxicity from radiotherapy. This emphasizes the need for careful radiation treatment planning to maximize the therapeutic ratio. We sought to evaluate how often unacceptable doses (UDs) to organs at risk (OARs) occur and the associated factors for patients receiving RNI in daily practice. METHODS AND MATERIALS: Treatment records of patients who received RNI from February 2012 to May 2015 were studied...
October 19, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28093644/guidelines-for-proton-pump-inhibitor-prescriptions-in-paediatric-intensive-care-unit
#15
P Joret-Descout, S Dauger, M Bellaiche, O Bourdon, S Prot-Labarthe
Background Stress ulcer prophylaxis (SUP) is recommended in some situations to prevent upper gastrointestinal bleeding and is a component of standard care for patients admitted to the intensive care unit (ICU). Proton pump inhibitors (PPIs), already among the most widely prescribed drug classes, are being increasingly used. Objective To describe PPI prescribing patterns and their changes after the dissemination of guidelines. Setting Paediatric ICU (PICU), Robert-Debré Teaching Hospital, Paris, France, which admits about 800 patients annually, from full-term neonates to 18-year-olds...
January 17, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28093229/antimicrobial-activity-and-mechanism-of-pdc213-an-endogenous-peptide-from-human-milk
#16
Yazhou Sun, Yahui Zhou, Xiao Liu, Fan Zhang, Linping Yan, Ling Chen, Xing Wang, Hongjie Ruan, Chenbo Ji, Xianwei Cui, Jiaqin Wang
Human milk has always been considered an ideal source of elemental nutrients to both preterm and full term infants in order to optimally develop the infant's tissues and organs. Recently, hundreds of endogenous milk peptides were identified in human milk. These peptides exhibited angiotensin-converting enzyme inhibition, immunomodulation, or antimicrobial activity. Here, we report the antimicrobial activity and mechanism of a novel type of human antimicrobial peptide (AMP), termed PDC213 (peptide derived from β-Casein 213-226 aa)...
January 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28092756/effects-of-assisted-outpatient-treatment-and-health-care-services-on-psychotic-symptoms
#17
Andres R Schneeberger, Christian G Huber, Undine E Lang, Kristina H Muenzenmaier, Dorothy Castille, Matthias Jaeger, Azizi Seixas, Julia Sowislo, Bruce G Link
RATIONALE: An ongoing debate concerns acceptability, benefits, and shortcomings of coercive treatment such as assisted outpatient treatment (AOT). The hypothesis that involuntary commitment to outpatient treatment may lead to a better clinical outcome for a subgroup of persons with severe mental illness (SMI) is controversial. Nonetheless, positive effects of AOT may be mediated by an increased availability of healthcare resources or increased service use. OBJECTIVE: The purpose of the present study is to evaluate the course of delusions, hallucinations, and negative symptoms among patients with SMI receiving AOT compared to patients receiving non-compulsory treatment (NCT)...
January 6, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28091436/acute-kidney-injury-in-lagos-pattern-outcomes-and-predictors-of-in-hospital-mortality
#18
B T Bello, A A Busari, C O Amira, Y R Raji, R W Braimoh
CONTEXT: The pattern of acute kidney injury (AKI) differs significantly between developed and developing countries. AIMS: The aim of th study was to determine the pattern and clinical outcomes of AKI in Lagos, Southwest Nigeria. SETTINGS AND DESIGN: A retrospective review of hospital records of all patients with a diagnosis of AKI over a 20-month period. SUBJECTS AND METHODS: Records of 54 patients were reviewed. Information retrieved included, bio-data, etiology of AKI, results of laboratory investigations, and patient outcomes...
February 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28091389/trali-syndrome-during-the-treatment-of-a-plasmodium-falciparum-malaria-case
#19
Hülya Çaşkurlu, Rahman Nurmuhammedov, Zarni Htway
Malaria, which is one of the three most important infectious diseases globally, is endemic in many areas of the world. Plasmodium falciparum is not endemic to Turkey but can be seen after travel to epidemic countries. Transfusion-related acute lung injury (TRALI) syndrome is a rare disease, which may develop following the transfusion of all types of blood products, including plasma. Here we describe a case of TRALI syndrome in a 29-year-old male, who presented with fever after 15 days of returning from a business trip to Burkina Faso...
December 2016: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/28089383/-long-term-psychiatric-hospitalizations
#20
L Plancke, A Amariei
BACKGROUND: Long-term hospitalizations in psychiatry raise the question of desocialisation of the patients and the inherent costs. METHODS: Individual indicators were extracted from a medical administrative database containing full-time psychiatric hospitalizations for the period 2011-2013 of people over 16 years old living in the French region of Nord-Pas-de-Calais. We calculated the proportion of people who had experienced a hospitalization with a duration of 292 days or more during the study period...
January 11, 2017: Revue D'épidémiologie et de Santé Publique
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