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https://www.readbyqxmd.com/read/28649781/anti-d-reagents-should-be-chosen-accordingly-to-the-prevalence-of-d-variants-in-the-obstetric-population
#1
Jelena Lukacevic Krstic, Slavica Dajak, Jasna Bingulac-Popovic, Vesna Dogic, Jela Mratinovic-Mikulandra
BACKGROUND: Resolving ambiguous results of D antigen typing is crucial for appropriate and rational administration of anti-D immunoprophylaxis and transfusion practice in obstetric population. The aim of the study was to establish selection criteria of anti-D reagents for our population. METHODS: A total of 12 689 samples from primiparous women in Split-Dalmatia County, Croatia, were typed for RhD antigen during the period of 5 years. Ambiguous results were submitted to additional serologic investigation and genotyping...
June 26, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28634309/-investigation-of-repeatability-of-residual-urine-volume-measurement-for-lower-urinary-tract-disorder-in-patients-with-lumbar-degenerative-disorders
#2
Yasufumi Ohtake, Jyunya Hanakita, Toshiyuki Takahashi, Manabu Minami, Mizuki Watanabe, Keita Kuraishi, Hirohiko Nakamura, Manabu Ueno, Taigo Kawaoka
STUDY DESIGN: prospective study OBJECTIVE:To evaluate repeatability of residual urine(RU)volume measurement(RUM)in patients with lumbar degenerative disorders. SUMMARY OF BACKGROUND DATA: RUM by abdominal echo is a non-invasive modality to evaluate lower urinary tract disorder(LUTD), repeatability of which is not found in urological disorders. Additionally, its repeatability has not been confirmed in spinal disorders. The authors examined repeatability of RUM for evaluation of LUTD in patients with lumbar degenerative disorders...
June 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28620202/nanotopological-plate-stimulates-osteogenic-differentiation-through-taz-activation
#3
Jun-Ha Hwang, Dong-Hyun Lee, Mi Ran Byun, A Rum Kim, Kyung Min Kim, Jung Il Park, Ho Taek Oh, Eun Sook Hwang, Kyu Back Lee, Jeong-Ho Hong
The topographical environment, which mimics the stem cell niche, provides mechanical cues to regulate the differentiation of mesenchymal stem cells (MSC). Diverse topographical variations have been engineered to investigate cellular responses; however, the types of mechanical parameters that affect cells, and their underlying mechanisms remain largely unknown. In this study, we screened nanotopological pillars with size gradient to activate transcriptional coactivator with PDZ binding motif (TAZ), which stimulates osteogenesis of MSC...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28619119/transmission-of-a-novel-sonotubometry-acoustic-click-stimulus-in-healthy-and-patulous-eustachian-tube-subjects-a-retrospective-case-control-study
#4
Justin M Pyne, Yaw Amoako-Tuffour, Guy Earle, Graham McIntyre, Michael B Butler, Manohar Bance
BACKGROUND: Eustachian tube (ET) dysfunction can be very difficult to diagnose accurately. Our aim is to determine whether a newly developed sonotubometric test using clicks can reliably detect ET opening during swallowing in normal ET subjects, and patulous ET (PET) in subjects with ET dysfunction. METHODS: Sixteen subjects (19 normal ET ears and 6 PET ears) were individually placed in a sound-isolated audiometry booth and subjected to a 1000Hz click train stimulus, played through the nose...
June 15, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28597368/health-related-resource-use-measurement-instruments-for-intersectoral-costs-and-benefits-in-the-education-and-criminal-justice-sectors
#5
REVIEW
Susanne Mayer, Aggie T G Paulus, Agata Łaszewska, Judit Simon, Ruben M W A Drost, Dirk Ruwaard, Silvia M A A Evers
BACKGROUND: Intersectoral costs and benefits (ICBs), i.e. costs and benefits of healthcare interventions outside the healthcare sector, can be a crucial component in economic evaluations from the societal perspective. Pivotal to their estimation is the existence of sound resource-use measurement (RUM) instruments; however, RUM instruments for ICBs in the education or criminal justice sectors have not yet been systematically collated or their psychometric quality assessed. This review aims to fill this gap...
June 8, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28575452/selective-disruption-of-an-oncogenic-mutant-allele-by-crispr-cas9-induces-efficient-tumor-regression
#6
Taeyoung Koo, A-Rum Yoon, Hee-Yeon Cho, Sangsu Bae, Chae-Ok Yun, Jin-Soo Kim
Approximately 15% of non-small cell lung cancer cases are associated with a mutation in the epidermal growth factor receptor (EGFR) gene, which plays a critical role in tumor progression. With the goal of treating mutated EGFR-mediated lung cancer, we demonstrate the use of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) system to discriminate between the oncogenic mutant and wild-type EGFR alleles and eliminate the carcinogenic mutant EGFR allele with high accuracy...
May 31, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28546002/catechins-activate-muscle-stem-cells-by-myf5-induction-and-stimulate-muscle-regeneration
#7
A Rum Kim, Kyung Min Kim, Mi Ran Byun, Jun-Ha Hwang, Jung Il Park, Ho Taek Oh, Hyo Kyeong Kim, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Muscle weakness is one of the most common symptoms in aged individuals and increases risk of mortality. Thus, maintenance of muscle mass is important for inhibiting aging. In this study, we investigated the effect of catechins, polyphenol compounds in green tea, on muscle regeneration. We found that (-)-epicatechin gallate (ECG) and (-)-epigallocatechin-3-gallate (EGCG) activate satellite cells by induction of Myf5 transcription factors. For satellite cell activation, Akt kinase was significantly induced after ECG treatment and ECG-induced satellite cell activation was blocked in the presence of Akt inhibitor...
July 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28530407/gadolinium-complex-of-1-4-7-10-tetraazacyclododecane-1-4-7-trisacetic-acid-do3a-ethoxybenzyl-eob-conjugate-as-a-new-macrocyclic-hepatobiliary-mri-contrast-agent
#8
Ah Rum Baek, Hee-Kyung Kim, Subin Park, Gang Ho Lee, Hyo Jeung Kang, Jae-Chang Jung, Joon-Suk Park, Hun-Kyu Ryeom, Tae-Jeong Kim, Yongmin Chang
We report the synthesis of a macrocyclic Gd chelate based on a 1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid (DO3A) coordinationn cage bearing an ethoxybenzyl (EOB) moiety and discuss its use as a T1 hepatobiliary magnetic resonance imaging (MRI) contrast agent. The new macrocyclic liver agent shows high chelation stability and high r1 relaxivity compared with linear-type Gd chelates, which are the current clinically approved liver agents. Our macrocyclic, liver-specific Gd chelate was evaluated in vivo through biodistribution analysis and liver MRI, which demonstrated its high tumor detection sensitivity and suggested that the new Gd complex is a promising contrast agent for liver cancer imaging...
May 31, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28449534/safety-profile-of-egfr-targeted-hybrid-vector-system-composed-of-pamam-dendrimer-and-oncolytic-adenovirus
#9
COMMENT
A-Rum Yoon, Dayananda Kasala, Jinwoo Hong, Chae-Ok Yun
No abstract text is available yet for this article.
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28434831/submuscular-versus-subcutaneous-ulnar-nerve-transposition-a-cadaveric-model-evaluating-their-role%C3%A2-in-primary-ulnar-nerve-repair-at-the-elbow
#10
Brandon S Smetana, Edward W Jernigan, Wayne A Rummings, Paul S Weinhold, Reid W Draeger, J Megan M Patterson
PURPOSE: To investigate the length gained from subcutaneous and submuscular transposition of the ulnar nerve at the elbow. Specifically, the study aimed to define an expected nerve gap able to be overcome, and to determine if a difference between transposition techniques exists. METHODS: Eleven cadaveric specimens from the scapula to fingertip were procured. In situ decompression and mobilization of the ulnar nerve at the elbow followed by simulated laceration of the nerve was performed...
April 20, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28398625/novel-creation-of-a-rum-flavor-lexicon-through-the-use-of-web-based-material
#11
Chelsea M Ickes, Soo-Yeun Lee, Keith R Cadwallader
Flavor lexicons help both manufacturers and consumers communicate the intricacies of flavor nuances they experience within a product. Lexicon development typically requires the use of a trained sensory panel to evaluate a representative sample set of the product category to generate terms that describe certain product attributes. In the case of rum, there is considerable variation in terms of style, flavor characteristics, and the sheer number of rums produced making it difficult to create a lexicon in this manner...
May 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28342344/water-hardness-determines-226-ra-uptake-in-the-tropical-freshwater-mussel
#12
Che Doering, Andreas Bollhöfer
Chemical data for freshwater mussels (Velesunio spp.) and water from 15 sampling sites in the Alligator Rivers Region and Rum Jungle uranium provinces in tropical Northern Australia were analysed to develop a predictive model of radium-226 ((226)Ra) bioaccumulation for variable water calcium (Ca) and magnesium (Mg) concentrations. Application of the model as a (226)Ra screening approach for freshwater mussels in tropical waterbodies potentially impacted by operational or remediated uranium mine sites is discussed in relation to Mudginberri Billabong, located approximately 12 km downstream of Ranger uranium mine in the Alligator Rivers Region...
June 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28315325/-epigallocatechin-3-gallate-stimulates-myogenic-differentiation-through-taz-activation
#13
A Rum Kim, Kyung Min Kim, Mi Ran Byun, Jun-Ha Hwang, Jung Il Park, Ho Taek Oh, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Muscle loss is a typical process of aging. Green tea consumption is known to slow down the progress of aging. Their underlying mechanisms, however, remain largely unknown. In this study, we investigated the effect of (-)-epigallocatechin-3-gallate (EGCG), a polyphenolic compound of green tea, on myogenic differentiation and found that EGCG significantly increases myogenic differentiation. After EGCG treatment, the expression of myogenic marker genes, such as myosin heavy chain, are increased through activation of TAZ, a transcriptional coactivator with a PDZ-binding motif...
April 29, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28259279/volar-anatomy-of-the-proximal-phalanx-implications-for-screw-length-selection-for-fixation-of-shaft-fractures
#14
P Barrett Honeycutt, Edward W Jernigan, Wayne A Rummings, Peter J Stern, Reid W Draeger
PURPOSE: To investigate the anatomy of the volar surface of the proximal phalanx of the hand, specifically the longitudinal groove running along the volar phalangeal shaft. METHODS: We measured skeletonized proximal phalanges from 10 embalmed human cadaver hands at 5 equidistant points along the shaft. The difference between the maximum dorsal-palmar thickness of the shaft and thickness measured from the center of the volar groove to the most dorsal aspect of the phalanx indicated the depth of the groove at each point...
March 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28214780/distress-intolerance-in-the-parents-of-substance-dependent-patients
#15
Suat Ekinci, Hanife Uğur Kural
The purpose of this study was to determine levels of Distress Tolerance (DT) and to compare levels of DT, depression, and anxiety in the parents of substance dependent patients. This sample included 40 parents of inpatients undergoing treatment for substance dependence (SDPP) in the Balıklı Rum Hospital, Istanbul, Turkey. A healthy control group was recruited of 40 individuals with no Axis I diagnoses that were counterbalanced with the SDPP group in terms of age and sex. All study participants completed a sociodemographic data form and the Beck Depression Inventory, the Beck Anxiety Inventory, the State & Trait Anxiety Inventory, and the Distress Tolerance Scale...
May 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28190943/sugar-sweetened-beverage-warning-labels-lessons-learned-from-the-tobacco-industry
#16
Lucy Popova
Tobacco warning labels effectively educate consumers about the harms of tobacco and reduce smoking behavior. Lessons from tobacco warning labels can be applied to developing and implementing warning labels for sugar-sweetened beverages (SSBs). Large pictorial rotating warnings are particularly effective. Dental professionals can be an important voice in countering the industry's efforts to create controversy around the effects of SSBs and in advocating for effective warning labels based on the evidence from the tobacco warning labels...
October 2016: Journal of the California Dental Association
https://www.readbyqxmd.com/read/28167315/modeling-of-un-deformed-chip-thickness-in-rum-process-and-study-of-size-effects-in-%C3%AE-rum
#17
Anil Kumar Jain, Pulak M Pandey
Un-deformed chip thickness is a critical parameter in machining processes. Measuring un-deformed chip thickness experimentally is a complicated process, especially in micro machining and may not even be measured accurately. The un-deformed chip thickness has an influence on material removal rate, cutting forces, specific energy and surface finish etc. In ceramic machining, it is also an indication of material removal mode such as ductile or brittle fracture. In the present study, an effort is made to model undeformed chip thickness, cutting forces and specific cutting energy in rotary ultrasonic machining (RUM) applied to the side milling operation...
May 2017: Ultrasonics
https://www.readbyqxmd.com/read/28123043/psychiatric-disorders-and-general-functioning-in-low-birth-weight-adults-a-longitudinal-study
#18
Astrid M W Lærum, Solveig Klæbo Reitan, Kari Anne I Evensen, Stian Lydersen, Ann-Mari Brubakk, Jon Skranes, Marit S Indredavik
OBJECTIVE: To examine psychiatric morbidity and overall functioning in adults born with low birth weight compared with normal birth weight controls at age 26 years and to study longitudinal trajectories of psychiatric morbidity from early adolescence to adulthood. METHODS: Prospective cohort study wherein 44 preterm very low birth weight (≤1500 g), 64 term small for gestational age (SGA; <10th percentile), and 81 control adults were examined using the MINI-International Neuropsychiatric Interview: M...
January 25, 2017: Pediatrics
https://www.readbyqxmd.com/read/28121172/cost-utility-analysis-of-cardiac-rehabilitation-after-conventional-heart-valve-surgery-versus-usual-care
#19
Tina Birgitte Hansen, Ann Dorthe Zwisler, Selina Kikkenborg Berg, Kirstine Lærum Sibilitz, Lau Caspar Thygesen, Jakob Kjellberg, Patrick Doherty, Neil Oldridge, Rikke Søgaard
Background While cardiac rehabilitation in patients with ischaemic heart disease and heart failure is considered cost-effective, this evidence may not be transferable to heart valve surgery patients. The aim of this study was to investigate the cost-effectiveness of cardiac rehabilitation following heart valve surgery. Design We conducted a cost-utility analysis based on a randomised controlled trial of 147 patients who had undergone heart valve surgery and were followed for 6 months. Methods Patients were randomised to cardiac rehabilitation consisting of 12 weeks of physical exercise training and monthly psycho-educational consultations or to usual care...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28060849/behavior-of-pigs-reared-in-enriched-environment-alternatives-to-extend-pigs-attention
#20
Simone Pereira Machado, Fabiana Ribeiro Caldara, Luciana Foppa, Rafael de Moura, Liliane Maria Piano Gonçalves, Rodrigo Garófallo Garcia, Irenilza de Alencar Nääs, Viviane Maria Oliveira Dos Santos Nieto, Geyssane Farias de Oliveira
Three trials were carried out in a completely randomized design aiming to assess the behavior of pigs in growth phase in enriched environments. Trial 1 evaluated the effects of frequency of availability of environmental enrichment. The animals were assigned to four treatments: 1) control with no enrichment object; 2) objects provided for six consecutive days uninterruptedly; 3) objects provided on alternate days, and 4) objects provided for six consecutive days taken away by the end of the afternoon and replaced at dawn...
2017: PloS One
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