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https://www.readbyqxmd.com/read/29030866/characterization-of-sensory-differences-in-mixing-and-premium-rums-through-the-use-of-descriptive-sensory-analysis
#1
Chelsea M Ickes, Keith R Cadwallader
This study identified and quantitated perceived sensory differences between 7 premium rums and 2 mixing rums using a hybrid of the Quantitative Descriptive Analysis and Spectrum methods. In addition, the results of this study validated the previously developed rum flavor wheel created from web-based materials. Results showed that the use of the rum flavor wheel aided in sensory term generation, as 17 additional terms were generated after the wheel was provided to panelists. Thirty-eight sensory terms encompassing aroma, aroma-by-mouth, mouthfeel, taste and aftertaste modalities, were generated and evaluated by the panel...
October 14, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28950246/towards-reporting-standards-for-neuropsychological-study-results-a-proposal-to-minimize-communication-errors-with-standardized-qualitative-descriptors-for-normalized-test-scores
#2
Mike R Schoenberg, Ruba S Rum
OBJECTIVE: Rapid, clear and efficient communication of neuropsychological results is essential to benefit patient care. Errors in communication are a lead cause of medical errors; nevertheless, there remains a lack of consistency in how neuropsychological scores are communicated. A major limitation in the communication of neuropsychological results is the inconsistent use of qualitative descriptors for standardized test scores and the use of vague terminology. PATIENTS AND METHODS: PubMed search from 1 Jan 2007 to 1 Aug 2016 to identify guidelines or consensus statements for the description and reporting of qualitative terms to communicate neuropsychological test scores was conducted...
July 25, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28946479/acoustic-cavitation-promoted-lipase-catalysed-synthesis-of-isobutyl-propionate-in-solvent-free-system-optimization-and-kinetic-studies
#3
Kajal S Jaiswal, Virendra K Rathod
The present work highlights the effect of ultrasound on enzymatic synthesis of isobutyl propionate, a rum flavor by esterification of isobutanol and propionic acid in non-aqueous, solvent free system (SFS) using Fermase CALB™10000. The optimization study for different variables in presence of ultrasound showed a maximum conversion of 95.14% at 60°C temperature, 4% w/w enzyme dose, 1:3 acid:alcohol ratio, 40W power, 25kHz frequency, 50% duty cycle and 150rpm speed in 3h as compared to 10h of conventional method...
January 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28939028/src-activates-taz-for-intestinal-tumorigenesis-and-regeneration
#4
Mi Ran Byun, Jun-Ha Hwang, A Rum Kim, Kyung Min Kim, Jung Il Park, Ho Taek Oh, Eun Sook Hwang, Jeong-Ho Hong
Proto-oncogene tyrosine-protein kinase Src (cSRC) is involved in colorectal cancer (CRC) development and damage-induced intestinal regeneration, although the cellular mechanisms involved are poorly understood. Here, we report that transcriptional coactivator with PDZ binding domain (TAZ) is activated by cSRC, regulating CRC cell proliferation and tumor formation, where cSRC overexpression increases TAZ expression in CRC cells. In contrast, knockdown of cSRC decreases TAZ expression. Additionally, direct phosphorylation of TAZ at Tyr316 by cSRC stimulates nuclear localization and facilitates transcriptional enhancer factor TEF-3 (TEAD4)-mediated transcription...
September 20, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28929492/potent-antitumor-effect-of-tumor-microenvironment-targeted-oncolytic-adenovirus-against-desmoplastic-pancreatic-cancer
#5
Yan Li, JinWoo Hong, Joung-Eun Oh, A-Rum Yoon, Chae-Ok Yun
Pancreatic cancer is a leading cause of cancer-related death. Desmoplastic pancreatic tumors exhibit excessive extracellular matrix (ECM) and are thus highly resistant to anticancer therapeutics, since the ECM restricts drug penetration and dispersion. Here, we designed and generated two hypoxia-responsive and cancer-specific hybrid promoters, H(mT)E and H(E)mT. Transgene expression driven by each hybrid promoter was markedly higher under hypoxic conditions than normoxic conditions. Moreover, H(E)mT-driven transgene expression was highly cancer-specific and was superior to that of H(mT)E-driven expression...
September 20, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28918576/effect-of-heat-stress-on-rumen-temperature-of-three-breeds-of-cattle
#6
A M Lees, J C Lees, A T Lisle, M L Sullivan, J B Gaughan
Thirty-six steers (12 of each Angus, Charolais, and Brahman) with an initial BW of 318.5 ± 6.7 kg were used in a 130-day study. Two treatments were imposed: un-shaded and shaded (3 m(2)/animal; 90% solar block shade cloth). On day 1, steers were administered with rumen temperature boluses. Rumen temperatures (T RUM) were obtained at 10 min intervals over the duration of the study to determine differences in T RUM between Bos indicus and Bos taurus cattle. Six feedlot pens (162 m(2)) were used with six steers (2/breed) per pen with three pens/treatment...
September 16, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28910351/lab-meets-real-life-a-laboratory-assessment-of-spontaneous-thought-and-its-ecological-validity
#7
Christine Kuehner, Annett Welz, Iris Reinhard, Georg W Alpers
People's minds frequently wander towards self-generated thoughts, which are unrelated to external stimuli or demands. These phenomena, referred to as "spontaneous thought" (ST) and "mind wandering" (MW), have previously been linked with both costs and benefits. Current assessments of ST and MW have predominantly been conducted in the laboratory, whereas studies on the ecological validity of such lab-related constructs and their interrelations are rare. The current study examined the stability of ST dimensions assessed in the lab and their predictive value with respect to MW, repetitive negative thought (uncontrollable rumination, RUM), and affect in daily life...
2017: PloS One
https://www.readbyqxmd.com/read/28895876/drilling-high-precision-holes-in-ti6al4v-using-rotary-ultrasonic-machining-and-uncertainties-underlying-cutting-force-tool-wear-and-production-inaccuracies
#8
M A K Chowdhury, A M M Sharif Ullah, Saqib Anwar
Ti6Al4V alloys are difficult-to-cut materials that have extensive applications in the automotive and aerospace industry. A great deal of effort has been made to develop and improve the machining operations of Ti6Al4V alloys. This paper presents an experimental study that systematically analyzes the effects of the machining conditions (ultrasonic power, feed rate, spindle speed, and tool diameter) on the performance parameters (cutting force, tool wear, overcut error, and cylindricity error), while drilling high precision holes on the workpiece made of Ti6Al4V alloys using rotary ultrasonic machining (RUM)...
September 12, 2017: Materials
https://www.readbyqxmd.com/read/28894980/short-communication-using-infrared-thermography-as-an-in-situ-measure-of-core-body-temperature-in-lot-fed-angus-steers
#9
Angela M Lees, J C Lees, V Sejian, A L Wallage, J B Gaughan
Thirty-six Black Angus steers were used in a replicated study; three replicates of 12 steers/replicate. Steers had an initial non-fasted BW of 392.3 ± 5.1, 427.5 ± 6.3, and 392.7 ± 3.7 kg for each replicate, respectively. Steers were housed outside in individual animal pens (10 m × 3.4 m). Each replicate was conducted over a 6-day period where infrared thermography (IRT) images were collected at 3-h intervals, commencing at 0600 h on day 1 and concluding at 0600 h on day 6. Rumen temperatures (T RUM) were measured at 10-min intervals for the duration of each replicate using a radio-frequency identification (RFID) rumen bolus...
September 11, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28783792/comparison-of-the-performance-of-different-microbial-source-tracking-markers-among-european-and-north-african-regions
#10
Mariem Yahya, Anicet R Blanch, Wim G Meijer, Katerina Antoniou, Fatma Hmaied, Elisenda Ballesté
Microbial source tracking (MST) has been extensively used to detect the sources of fecal pollution in water. The inclusion of MST in water management strategies improves the ecological status of the ecosystem and human and animal health under interdisciplinary analysis in all aspects of health care for humans, animals, and the environment (One Health approach). In this study, the performance of MST markers targeting host-specific Bacteroidales (HF183 and Rum-2-Bac) and species (HMBif and CWBif) were evaluated in raw sewage collected from human, ruminant, swine, and poultry sources in Tunisia, Cyprus, Ireland, and Spain...
July 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28731266/a-randomized-double-blind-placebo-controlled-crossover-study-of-the-effects-of-levetiracetam-on-cognition-mood-and-balance-in-healthy-older-adults
#11
RANDOMIZED CONTROLLED TRIAL
Mike R Schoenberg, Ruba S Rum, Katie E Osborn, Mary Ann Werz
OBJECTIVE: The cognitive and mood effects of levetiracetam (LEV) in older adults are not known. This study compared the cognitive and mood effects of LEV to placebo in healthy older adults. METHODS: Cognitive, mood, and balance variables were compared between LEV and placebo using a randomized, double-blind, placebo-controlled crossover study with two 5-week treatment periods. Healthy volunteers (n = 20) aged 65-80 (mean age 72.4) received either LEV or placebo in which the LEV target dose was 1,000 mg/day...
September 2017: Epilepsia
https://www.readbyqxmd.com/read/28717811/effect-on-body-weight-quality-of-life-and-appetite-following-individualized-nutritional-counselling-to-home-living-elderly-after-rehabilitation-an-open-randomized-trial
#12
J Andersson, E Hulander, E Rothenberg, P Iversen
OBJECTIVES: We examined if individually-adapted nutritional counselling could prevent > 5% weight loss among elderly patients 3 months after discharge from a rehabilitation institution. In addition we assessed quality of life (QoL) and appetite. DESIGN: An open, randomized trial. SETTING: Godthaab Health and Rehabilitation Institution in Bærum, Norway. PARTICIPANTS: Patients identified as being undernourished or at risk of disease-related malnutrition using the Nutritional Risk Screening tool NRS-2002...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28649781/anti-d-reagents-should-be-chosen-accordingly-to-the-prevalence-of-d-variants-in-the-obstetric-population
#13
Jelena Lukacevic Krstic, Slavica Dajak, Jasna Bingulac-Popovic, Vesna Dogic, Jela Mratinovic-Mikulandra
BACKGROUND: Resolving ambiguous results of D antigen typing is crucial for appropriate and rational administration of anti-D immunoprophylaxis and transfusion practice in obstetric population. The aim of the study was to establish selection criteria of anti-D reagents for our population. METHODS: A total of 12 689 samples from primiparous women in Split-Dalmatia County, Croatia, were typed for RhD antigen during the period of 5 years. Ambiguous results were submitted to additional serologic investigation and genotyping...
June 26, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28634309/-investigation-of-repeatability-of-residual-urine-volume-measurement-for-lower-urinary-tract-disorder-in-patients-with-lumbar-degenerative-disorders
#14
Yasufumi Ohtake, Jyunya Hanakita, Toshiyuki Takahashi, Manabu Minami, Mizuki Watanabe, Keita Kuraishi, Hirohiko Nakamura, Manabu Ueno, Taigo Kawaoka
STUDY DESIGN: prospective study OBJECTIVE:To evaluate repeatability of residual urine(RU)volume measurement(RUM)in patients with lumbar degenerative disorders. SUMMARY OF BACKGROUND DATA: RUM by abdominal echo is a non-invasive modality to evaluate lower urinary tract disorder(LUTD), repeatability of which is not found in urological disorders. Additionally, its repeatability has not been confirmed in spinal disorders. The authors examined repeatability of RUM for evaluation of LUTD in patients with lumbar degenerative disorders...
June 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28620202/nanotopological-plate-stimulates-osteogenic-differentiation-through-taz-activation
#15
Jun-Ha Hwang, Dong-Hyun Lee, Mi Ran Byun, A Rum Kim, Kyung Min Kim, Jung Il Park, Ho Taek Oh, Eun Sook Hwang, Kyu Back Lee, Jeong-Ho Hong
The topographical environment, which mimics the stem cell niche, provides mechanical cues to regulate the differentiation of mesenchymal stem cells (MSC). Diverse topographical variations have been engineered to investigate cellular responses; however, the types of mechanical parameters that affect cells, and their underlying mechanisms remain largely unknown. In this study, we screened nanotopological pillars with size gradient to activate transcriptional coactivator with PDZ binding motif (TAZ), which stimulates osteogenesis of MSC...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28619119/transmission-of-a-novel-sonotubometry-acoustic-click-stimulus-in-healthy-and-patulous-eustachian-tube-subjects-a-retrospective-case-control-study
#16
Justin M Pyne, Yaw Amoako-Tuffour, Guy Earle, Graham McIntyre, Michael B Butler, Manohar Bance
BACKGROUND: Eustachian tube (ET) dysfunction can be very difficult to diagnose accurately. Our aim is to determine whether a newly developed sonotubometric test using clicks can reliably detect ET opening during swallowing in normal ET subjects, and patulous ET (PET) in subjects with ET dysfunction. METHODS: Sixteen subjects (19 normal ET ears and 6 PET ears) were individually placed in a sound-isolated audiometry booth and subjected to a 1000Hz click train stimulus, played through the nose...
June 15, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28597368/health-related-resource-use-measurement-instruments-for-intersectoral-costs-and-benefits-in-the-education-and-criminal-justice-sectors
#17
REVIEW
Susanne Mayer, Aggie T G Paulus, Agata Łaszewska, Judit Simon, Ruben M W A Drost, Dirk Ruwaard, Silvia M A A Evers
BACKGROUND: Intersectoral costs and benefits (ICBs), i.e. costs and benefits of healthcare interventions outside the healthcare sector, can be a crucial component in economic evaluations from the societal perspective. Pivotal to their estimation is the existence of sound resource-use measurement (RUM) instruments; however, RUM instruments for ICBs in the education or criminal justice sectors have not yet been systematically collated or their psychometric quality assessed. This review aims to fill this gap...
June 8, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28575452/selective-disruption-of-an-oncogenic-mutant-allele-by-crispr-cas9-induces-efficient-tumor-regression
#18
Taeyoung Koo, A-Rum Yoon, Hee-Yeon Cho, Sangsu Bae, Chae-Ok Yun, Jin-Soo Kim
Approximately 15% of non-small cell lung cancer cases are associated with a mutation in the epidermal growth factor receptor (EGFR) gene, which plays a critical role in tumor progression. With the goal of treating mutated EGFR-mediated lung cancer, we demonstrate the use of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated protein 9 (Cas9) system to discriminate between the oncogenic mutant and wild-type EGFR alleles and eliminate the carcinogenic mutant EGFR allele with high accuracy...
July 27, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28546002/catechins-activate-muscle-stem-cells-by-myf5-induction-and-stimulate-muscle-regeneration
#19
A Rum Kim, Kyung Min Kim, Mi Ran Byun, Jun-Ha Hwang, Jung Il Park, Ho Taek Oh, Hyo Kyeong Kim, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Muscle weakness is one of the most common symptoms in aged individuals and increases risk of mortality. Thus, maintenance of muscle mass is important for inhibiting aging. In this study, we investigated the effect of catechins, polyphenol compounds in green tea, on muscle regeneration. We found that (-)-epicatechin gallate (ECG) and (-)-epigallocatechin-3-gallate (EGCG) activate satellite cells by induction of Myf5 transcription factors. For satellite cell activation, Akt kinase was significantly induced after ECG treatment and ECG-induced satellite cell activation was blocked in the presence of Akt inhibitor...
July 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28530407/gadolinium-complex-of-1-4-7-10-tetraazacyclododecane-1-4-7-trisacetic-acid-do3a-ethoxybenzyl-eob-conjugate-as-a-new-macrocyclic-hepatobiliary-mri-contrast-agent
#20
Ah Rum Baek, Hee-Kyung Kim, Subin Park, Gang Ho Lee, Hyo Jeung Kang, Jae-Chang Jung, Joon-Suk Park, Hun-Kyu Ryeom, Tae-Jeong Kim, Yongmin Chang
We report the synthesis of a macrocyclic Gd chelate based on a 1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid (DO3A) coordinationn cage bearing an ethoxybenzyl (EOB) moiety and discuss its use as a T1 hepatobiliary magnetic resonance imaging (MRI) contrast agent. The new macrocyclic liver agent shows high chelation stability and high r1 relaxivity compared with linear-type Gd chelates, which are the current clinically approved liver agents. Our macrocyclic, liver-specific Gd chelate was evaluated in vivo through biodistribution analysis and liver MRI, which demonstrated its high tumor detection sensitivity and suggested that the new Gd complex is a promising contrast agent for liver cancer imaging...
June 22, 2017: Journal of Medicinal Chemistry
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