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https://www.readbyqxmd.com/read/27905542/defining-an-olfactory-receptor-function-in-airway-smooth-muscle-cells
#1
William H Aisenberg, Jessie Huang, Wanqu Zhu, Premraj Rajkumar, Randy Cruz, Lakshmi Santhanam, Niranjana Natarajan, Hwan Mee Yong, Breann De Santiago, Jung Jin Oh, A-Rum Yoon, Reynold A Panettieri, Oliver Homann, John K Sullivan, Stephen B Liggett, Jennifer L Pluznick, Steven S An
Pathways that control, or can be exploited to alter, the increase in airway smooth muscle (ASM) mass and cellular remodeling that occur in asthma are not well defined. Here we report the expression of odorant receptors (ORs) belonging to the superfamily of G-protein coupled receptors (GPCRs), as well as the canonical olfaction machinery (Golf and AC3) in the smooth muscle of human bronchi. In primary cultures of isolated human ASM, we identified mRNA expression for multiple ORs. Strikingly, OR51E2 was the most highly enriched OR transcript mapped to the human olfactome in lung-resident cells...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27873566/pathological-and-phylogenetic-characterization-of-amphibiothecum-sp-infection-in-an-isolated-amphibian-lissotriton-helveticus-population-on-the-island-of-rum-scotland
#2
Caterina Fiegna, Charlotte L Clarke, Darren J Shaw, Johanna L Baily, Frances C Clare, Alexandra Gray, Trenton W J Garner, Anna L Meredith
Outbreaks of cutaneous infectious disease in amphibians are increasingly being attributed to an overlooked group of fungal-like pathogens, the Dermocystids. During the last 10 years on the Isle of Rum, Scotland, palmate newts (Lissotriton helveticus) have been reportedly afflicted by unusual skin lesions. Here we present pathological and molecular findings confirming that the pathogen associated with these lesions is a novel organism of the order Dermocystida, and represents the first formally reported, and potentially lethal, case of amphibian Dermocystid infection in the UK...
November 22, 2016: Parasitology
https://www.readbyqxmd.com/read/27832324/secretin-stimulated-mri-assessment-of-exocrine-pancreatic-function-in-patients-with-cystic-fibrosis-and-healthy-controls
#3
Adnan Madzak, Trond Engjom, Gaute K Wathle, Søren Schou Olesen, Erling Tjora, Pål R Njølstad, Birger Norderud Lærum, Asbjørn Mohr Drewes, Georg Dimcevski, Jens Brøndum Frøkjær, Ingfrid S Haldorsen
PURPOSE: Secretin-stimulated magnetic resonance imaging (s-MRI) and pancreatic diffusion weighted imaging (DWI) are novel non-invasive imaging techniques for assessment of exocrine pancreatic insufficiency (EPI). The aim was to validate s-MRI assessed pancreatic secreted volume using novel semi-automatic quantification software, and to assess the ability of s-MRI with DWI to diagnose EPI in patients with cystic fibrosis (CF). METHODS: s-MRI and DWI was performed in 19 patients with CF (median age 21 years; range 16-56; eight men) and in 10 healthy controls (HC) (median age 46 years; range 20-65; four men)...
November 10, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27823683/cardiac-rehabilitation-versus-usual-care-for-patients-treated-with-catheter-ablation-for-atrial-fibrillation-results-of-the-randomized-copenheartrfa-trial
#4
Signe S Risom, Ann-Dorthe Zwisler, Trine B Rasmussen, Kirstine Lærum Sibilitz, Trine L S Madsen, Jesper Hastrup Svendsen, Christian Gluud, Jane Lindschou, Per Winkel, Selina Kikkenborg Berg
BACKGROUND: To assess the effects of comprehensive cardiac rehabilitation compared with usual care on physical activity and mental health for patients treated with catheter ablation for atrial fibrillation. METHODS: The patients were randomized 1:1 stratified by paroxysmal or persistent atrial fibrillation and sex to cardiac rehabilitation consisting of 12 weeks physical exercise and four psycho-educational consultations plus usual care (cardiac rehabilitation group) versus usual care...
November 2016: American Heart Journal
https://www.readbyqxmd.com/read/27788585/influence-of-the-production-process-on-the-key-aroma-compounds-of-rum-from-molasses-to-the-spirit
#5
Laura Franitza, Michael Granvogl, Peter Schieberle
The production of rum consists of fermentation, distillation, and ageing. To check the influence of each step on the final rum aroma, molasses, mash, distillate, and the final rum were analyzed using the sensomics concept. The changes in key aroma compounds were determined by application of aroma extract dilution analysis (AEDA) in combination with gas chromatography-mass spectrometry for identification and by stable isotope dilution assays (SIDAs) for quantitation. Odor activity values (OAVs; ratio of concentration to respective odor threshold) were calculated for the compounds determined in the rum and, finally, the rum aroma was successfully simulated by recombination...
October 27, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27774436/evolution-and-diversity-of-the-antimicrobial-resistance-associated-mobilome-in-streptococcus-suis-a-probable-mobile-genetic-elements-reservoir-for-other-streptococci
#6
Jinhu Huang, Jiale Ma, Kexin Shang, Xiao Hu, Yuan Liang, Daiwei Li, Zuowei Wu, Lei Dai, Li Chen, Liping Wang
Streptococcus suis is a previously neglected, newly emerging multidrug-resistant zoonotic pathogen. Mobile genetic elements (MGEs) play a key role in intra- and interspecies horizontal transfer of antimicrobial resistance (AMR) determinants. Although, previous studies showed the presence of several MGEs, a comprehensive analysis of AMR-associated mobilome as well as their interaction and evolution has not been performed. In this study, we presented the AMR-associated mobilome and their insertion hotspots in S...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27750178/investigations-on-the-critical-feed-rate-guaranteeing-the-effectiveness-of-rotary-ultrasonic-machining
#7
Jianjian Wang, Pingfa Feng, Jianfu Zhang, Wanchong Cai, Hao Shen
Rotary ultrasonic machining (RUM) is a well-known and efficient method for manufacturing holes in brittle materials. RUM is characterized by improved material removal rates, reduced cutting forces and reduced edge chipping sizes at the hole exit. The aim of this study is to investigate the critical feed rate to guarantee the effectiveness of RUM. Experimental results on quartz glass and sapphire specimens show that when the feed rate exceeds a critical value, the cutting force increases abruptly, accompanied by a significant decrease of ultrasonic amplitude...
February 2017: Ultrasonics
https://www.readbyqxmd.com/read/27727412/medicines-use-in-hospitalised-children-current-status-and-outcome-after-an-intervention
#8
S N Thiyahiny, M G Sathiadas, K Sanchayan, C Vamadevan, R Balasubramaniam, S Sri Ranganathan
INTRODUCTION: Challenges in rational use of medicines (RUM) in children are different from that of adults. In Sri Lanka, data on RUM in children are limited. OBJECTIVE: To assess the current status and to investigate effectiveness of an intervention in improving RUM in children. METHODS: Non-randomised controlled before and after study design was employed. Study settings were one paediatric unit in two Teaching Hospitals one for intervention (IU) and the other as a control (CU) unit...
2016: Ceylon Medical Journal
https://www.readbyqxmd.com/read/27704848/non-targeted-lc-ms-metabolomics-approach-for-metabolic-profiling-of-plasma-and-urine-from-pigs-fed-branched-chain-amino-acids-for-maximum-growth-performance
#9
Elham Assadi Soumeh, Mette Skou Hedemann, Hanne Damgaard Poulsen, Etienne Corrent, Jacob van Milgen, Jan Værum Nørgaard
The metabolic response to plasma and urine of pigs when feeding an optimum level of BCAA for best growth performance is unknown. The objective of the current study was to identify the metabolic phenotype associated with the BCAA intake level that could be linked to the animal growth performance. Three dose-response studies were carried out to collect blood and urine samples from pigs fed increasing levels of Ile, Val, or Leu followed by a non-targeted LC-MS approach to characterize the metabolic profile of bio-fluids when dietary BCAA is optimum for animal growth...
October 5, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27652361/the-role-of-geriatric-assessment-tests-and-anthropometric-measurements-in-identifying-the-risk-of-falls-in-elderly-nursing-home-residents
#10
Bulent Yardimci, Sinan N Aran, Ismail Ozkaya, Sevki M Aksoy, Tarik Demir, Gulsen Tezcan, Aysegul Y Kaptanoglu
OBJECTIVES: To determine the relation among the risk of falls, geriatric assessment, and anthropometric measurements, including the mini mental state examination, geriatric depression scale, handgrip test, and key pinch test. METHODS: This prospective study included 89 residents hospitalized between May 2014 and September 2015 in the geriatric care unit of the Istanbul Balikli Rum Hospital, Istanbul, Turkey. Patients were followed-up for one year, and their falls were recorded...
October 2016: Saudi Medical Journal
https://www.readbyqxmd.com/read/27642372/trait-self-compassion-reflects-emotional-flexibility-through-an-association-with-high-vagally-mediated-heart-rate-variability
#11
Julie Lillebostad Svendsen, Berge Osnes, Per-Einar Binder, Ingrid Dundas, Endre Visted, Helge Nordby, Elisabeth Schanche, Lin Sørensen
Converging evidence shows a positive effect of self-compassion on self-reported well-being and mental health. However, few studies have examined the relation between self-compassion and psychophysiological measures. In the present study, we therefore examined the relation between trait self-compassion and vagally mediated heart rate variability (vmHRV) in 53 students (39 female, mean age = 23.63). Trait self-compassion was assessed using the Self-Compassion Scale, and resting vmHRV was measured during a 5-min ECG baseline period...
2016: Mindfulness
https://www.readbyqxmd.com/read/27610182/clinical-course-and-prognostic-factors-of-childhood-immune-thrombocytopenia-single-center-experience-of-10-years
#12
Jae Yeob Jung, A Rum O, Je Keong Kim, Meerim Park
PURPOSE: This study aimed to evaluate the clinical course of childhood immune thrombocytopenia (ITP) and to assess the risk factors for developing chronic ITP. METHODS: The records of 64 children diagnosed with ITP from November 2005 and December 2014 at single center were retrospectively analyzed. RESULTS: The median age at diagnosis and the median platelet count were 1 year (range, 1 month to 15 years) and 9×10(9)/L (range, 0-84×10(9)/L), respectively...
August 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27601491/prevalence-of-factors-associated-with-malnutrition-among-acute-geriatric-patients-in-norway-a-cross-sectional-study
#13
Ellisiv Lærum Jacobsen, Therese Brovold, Astrid Bergland, Asta Bye
OBJECTIVES: Data on acute geriatric patients' nutritional status are lacking, and the associations among physical function, sarcopenia, health status and nutritional status are not sufficiently investigated in this population. The aims of this study are to investigate (1) nutritional status and sarcopenia in a group of acute geriatric patients, (2) the association between nutritional status, physical function and sarcopenia in acute geriatric patients, controlling for health status. DESIGN: A cross-sectional study...
2016: BMJ Open
https://www.readbyqxmd.com/read/27562632/protein-adsorption-and-reorganization-on-nanoparticles-probed-by-the-coffee-ring-effect-application-to-single-point-mutation-detection
#14
Stéphanie Devineau, Manos Anyfantakis, Laurent Marichal, Laurent Kiger, Mathieu Morel, Sergii Rudiuk, Damien Baigl
The coffee-ring effect denotes the accumulation of particles at the edge of an evaporating sessile drop pinned on a substrate. Because it can be detected by simple visual inspection, this ubiquitous phenomenon can be envisioned as a robust and cost-effective diagnostic tool. Toward this direction, here we systematically analyze the deposit morphology of drying drops containing polystyrene particles of different surface properties with various proteins (bovine serum albumin (BSA) and different forms of hemoglobin)...
September 14, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27553947/assessment-of-soil-quality-parameters-using-multivariate-analysis-in-the-rawal-lake-watershed
#15
Shahana Firdous, Shaheen Begum, Azra Yasmin
Soil providing a wide array of ecosystem services is subjected to quality deterioration due to natural and anthropogenic factors. Most of the soils in Pakistan have poor status of available plant nutrients and cannot support optimum levels of crop productivity. The present study statistically analyzed ten soil quality parameters in five subwatersheds (Bari Imam, Chattar, Rumli, Shahdra, and Shahpur) of the Rawal Lake. Analysis of variance (ANOVA), cluster analysis (CA), and principal component analysis (PCA) were performed to evaluate correlation in soil quality parameters on spatiotemporal and vertical scales...
December 0: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27501431/red-deer-bone-and-antler-collagen-are-not-isotopically-equivalent-in-carbon-and-nitrogen
#16
Rhiannon E Stevens, Tamsin C O'Connell
RATIONALE: Bone and antler collagen δ(13) C and δ(15) N values are often assumed to be equivalent when measured in palaeodietary, palaeoclimate and palaeocological studies. Although compositionally similar, bone grows slowly and is remodelled whereas antler growth is rapid and remodelling does not occur. These different patterns of growth could result in isotopic difference within antler and between the two tissue types. Here we test whether red deer (Cervus elaphus) bone and antler δ(13) C and δ(15) N values are equivalent, and whether intra-antler isotopic values are uniform...
September 15, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/27462367/identification-and-genome-reconstruction-of-abundant-distinct-taxa-in-microbiomes-from-one-thermophilic-and-three-mesophilic-production-scale-biogas-plants
#17
Yvonne Stolze, Andreas Bremges, Madis Rumming, Christian Henke, Irena Maus, Alfred Pühler, Alexander Sczyrba, Andreas Schlüter
BACKGROUND: Biofuel production from conversion of biomass is indispensable in the portfolio of renewable energies. Complex microbial communities are involved in the anaerobic digestion process of plant material, agricultural residual products and food wastes. Analysis of the genetic potential and microbiology of communities degrading biomass to biofuels is considered to be the key to develop process optimisation strategies. Hence, due to the still incomplete taxonomic and functional characterisation of corresponding communities, new and unknown species are of special interest...
2016: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/27441548/effects-of-mischievous-responding-on-universal-mental-health-screening-i-love-rum-raisin-ice-cream-really-i-do
#18
Michael J Furlong, Aileen Fullchange, Erin Dowdy
Student surveys are often used for school-based mental health screening; hence, it is critical to evaluate the authenticity of information obtained via the self-report format. The objective of this study was to examine the possible effects of mischievous response patterns on school-based screening results. The present study included 1,857 high school students who completed a schoolwide screening for complete mental health. Student responses were reviewed to detect possible mischievous responses and to examine their association with other survey results...
July 21, 2016: School Psychology Quarterly
https://www.readbyqxmd.com/read/27375716/anthropometric-measurements-may-be-informative-for-nursing-home-acquired-pneumonia
#19
Bulent Yardimci, Sevki Murat Aksoy, Ismail Ozkaya, Tarik Demir, Gulsen Tezcan, Aysegul Yildirim Kaptanoglu
OBJECTIVE: To evaluate the relationship between anthropometric measurements and Nursing Home-Acquired Pneumonia (NHAP) risk. METHODS: Consecutive patients of 65 years or elderly who were living in the Balikli Rum Hospital Nursing Homes were included in this prospective study. At the beginning of this study, the patients' anthropometrics values were measured. The patients were followed for one year, and any incidences of pneumonia attacks were recorded. The relationship between the anthropometric measurements and pneumonia occurrences was analyzed...
May 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27348247/evolving-lessons-on-nanomaterial-coated-viral-vectors-for-local-and-systemic-gene-therapy
#20
Dayananda Kasala, A-Rum Yoon, Jinwoo Hong, Sung Wan Kim, Chae-Ok Yun
Viral vectors are promising gene carriers for cancer therapy. However, virus-mediated gene therapies have demonstrated insufficient therapeutic efficacy in clinical trials due to rapid dissemination to nontarget tissues and to the immunogenicity of viral vectors, resulting in poor retention at the disease locus and induction of adverse inflammatory responses in patients. Further, the limited tropism of viral vectors prevents efficient gene delivery to target tissues. In this regard, modification of the viral surface with nanomaterials is a promising strategy to augment vector accumulation at the target tissue, circumvent the host immune response, and avoid nonspecific interactions with the reticuloendothelial system or serum complement...
July 2016: Nanomedicine
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