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https://www.readbyqxmd.com/read/29880541/maternal-age-at-delivery-lung-function-and-asthma-in-offspring-a-population-based-survey
#1
Francisco Gómez Real, John A Burgess, Simona Villani, Julia Dratva, Joachim Heinrich, Christer Janson, Debbie Jarvis, Jennifer Koplin, Bénédicte Leynaert, Caroline Lodge, Birger N Lærum, Melanie C Matheson, Dan Norbäck, Ernst R Omenaas, Svein M Skulstad, Jordi Sunyer, Shyamali C Dharmage, Cecilie Svanes
There is limited information about potential impact of maternal age on the respiratory health of offspring. We investigated the association of maternal age at delivery with adult offspring's lung function, respiratory symptoms and asthma, and potential differences according to offspring sex.10 692 adults from 13 countries participating in the European Community Respiratory Health Survey (ECRHS) II responded to standardised interviews and provided lung function measurements and serum for IgE measurements at age 25-55 years...
June 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29869876/an-optical-configuration-of-crossed-beam-photothermal-lens-spectrometer-operating-at-high-flow-velocities-and-its-application-for-cysteine-determination-in-human-serum-and-saliva
#2
Javad Yoosefian, Naader Alizadeh
Photothermal lens spectrometry (TLS) is a high sensitive technique for trace determination of non-fluorescent materials. Previous photothermal lens spectrometers suffer from operating limitations at high flow velocities, arising from taking the heated element off the probe beam direction which results in a decrease in the thermal lens (TL) signal. Herein, we describe an optical configuration of crossed-beam photothermal lens in transversal flow mode in which the propagating direction of the probe beam and liquid sample flow azimuth are concentric (CBTC)...
June 5, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29851350/in-situ-synthesis-of-magnetic-mesoporous-phenolic-resin-for-the-selective-enrichment-of-glycopeptides
#3
Quanqing Zhang, Yuanyu Huang, Biyun Jiang, Yajun Hu, Juanjuan Xie, Xing Gao, Bin Jia, Huali Shen, Weijia Zhang, Pengyuan Yang
Protein glycosylation is a significant participant in a mass of biological processes, which is a pivotal protein post-translational modification. Due to the low contents of glycopeptides compared with nonglycopeptides and the microhetero-geneity of glycosylation sites, highly selective enrichment methods for the purification of glycopeptides are required for the comprehensive characterization of glycoproteomics. In this work, a type of magnetic mesoporous phenolic resin (MMP) was prepared using branched polyethylenimine (PEI) as a cross-linker from a homogeneous magnetic Fe3O4@SiO2 solution in a resorcinol/formaldehyde monomer aqueous system via an in situ emulsion polymerization procedure...
May 31, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29846501/ethyl-glucuronide-in-alcoholic-beverages
#4
Alexander Müller, Stefanie Iwersen-Bergmann
Aims: This study examines the biomarker ethyl glucuronide (EtG) in various alcoholic beverages. Short summary: The biomarker EtG was consistently found to be a natural compound of wine, whereas it was not detected in any of the other tested alcoholic beverages, which included various distilled spirits, liqueurs and beer of different types and geographical origins. Methods: Alcoholic beverages (n = 114) were analyzed by a validated liquid chromatography/tandem mass spectrometry assay...
May 26, 2018: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29801935/accuracy-in-screw-selection-in-a-cadaveric-small-bone-fracture-model
#5
Edward W Jernigan, P Barrett Honeycutt, J Megan M Patterson, Wayne A Rummings, Donald K Bynum, Reid W Draeger
PURPOSE: Using a cadaveric model simulating clinical situations experienced during open reduction and internal fixation of proximal phalangeal fractures, the aim of this study was to evaluate the relationship between level of training and the rates of short, long, and ideal screw length selection based on depth gauge use without fluoroscopy assistance. METHODS: A dorsal approach to the proximal phalanx was performed on the index, middle, and ring fingers of 4 cadaveric specimens, and 3 drill holes were placed in each phalanx...
May 22, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29764411/contrast-enhanced-ultrasonography-of-the-pancreas-shows-impaired-perfusion-in-pancreas-insufficient-cystic-fibrosis-patients
#6
Trond Engjom, Kim Nylund, Friedemann Erchinger, Marcus Stangeland, Birger Norderud Lærum, Martin Mézl, Radovan Jiřík, Odd Helge Gilja, Georg Dimcevski
BACKGROUND: Perfusion assessment of the pancreas is challenging and poorly evaluated. Pancreatic affection is a prevalent feature of cystic fibrosis (CF). Little is known about pancreatic perfusion in CF. We aimed to assess pancreatic perfusion by contrast-enhanced ultrasound (CEUS) analysed in the bolus-and-burst model and software. METHODS: We performed contrast enhanced ultrasound of the pancreas in 25 CF patients and 20 healthy controls. Perfusion data was analysed using a dedicated perfusion model providing the mean capillary transit-time (MTT), blood flow (BF) and blood-volume (BV)...
May 15, 2018: BMC Medical Imaging
https://www.readbyqxmd.com/read/29748568/carf-enrichment-promotes-epithelial-mesenchymal-transition-via-wnt-%C3%AE-catenin-signaling-its-clinical-relevance-and-potential-as-a-therapeutic-target
#7
Rajkumar S Kalra, Anupama Chaudhary, A-Rum Yoon, Priyanshu Bhargava, Amr Omar, Sukant Garg, Chae-Ok Yun, Sunil C Kaul, Renu Wadhwa
CARF (Collaborator of ARF)/CDKN2AIP was discovered as a novel ARF-binding protein. It has been established as an essential cell survival, p53-, and cell proliferation-regulatory protein. Although a moderate upregulation of CARF caused growth arrest and senescence, its excessively enriched levels were shown to facilitate aggressive proliferation and malignant transformation of cancer cells. Here, we examined the relevance of CARF levels in clinical tumors and found its amplification (both at gene and transcript levels) in a variety of invasive and metastatic malignancies...
May 11, 2018: Oncogenesis
https://www.readbyqxmd.com/read/29746697/adaptation-of-s-cerevisiae-to-fermented-food-environments-reveals-remarkable-genome-plasticity-and-the-footprints-of-domestication
#8
Jean-Luc Legras, Virginie Galeote, Frédéric Bigey, Carole Camarasa, Souhir Marsit, Thibault Nidelet, Isabelle Sanchez, Arnaud Couloux, Julie Guy, Ricardo Franco-Duarte, Marcet-Houben Marina, Toni Gabaldon, Dorit Schuller, José Paulo Sampaio, Sylvie Dequin
The budding yeast Saccharomyces cerevisiae can be found in the wild and is also frequently associated with human activities. Despite recent insights into the phylogeny of this species, much is still unknown about how evolutionary processes related to anthropogenic niches have shaped the genomes and phenotypes of S. cerevisiae. To address this question, we performed population-level sequencing of 82 S. cerevisiae strains from wine, flor, rum, dairy products, bakeries and the natural environment (oak trees). These genomic data enabled us to delineate specific genetic groups corresponding to the different ecological niches and revealed high genome content variation across the groups...
May 8, 2018: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29742581/niacin-and-selenium-attenuate-brain-injury-after-cardiac-arrest-in-rats-by-up-regulating-dj-1-akt-signaling
#9
Woon Yong Kwon, Gil Joon Suh, Kyung Su Kim, Yoon Sun Jung, Sung Hee Kim, A Rum Lee, Kyoung Min You, Min Ji Park
OBJECTIVES: To determine neuroprotective effects and mechanism of the combination therapy of niacin and selenium in cardiac arrest rats. DESIGN: Prospective laboratory study. SETTING: University laboratory. SUBJECTS: Rat cortex neurons and male Sprague-Dawley rats (n = 68). INTERVENTIONS: In rat cortex neurons underwent 90 minutes of oxygen-glucose deprivation and 22.5 hours of reoxygenation, effects of the combination therapy of niacin (0...
May 8, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29704089/bartenders-and-rum-shopkeepers-knowledge-of-and-attitudes-toward-problem-drinking-in-saint-vincent-and-the-grenadines
#10
Maryam Zafer, Shiyuan Liu, Craig L Katz
Harmful alcohol use encompasses a spectrum of habits, including heavy episodic drinking (HED) which increases the risk of acute alcohol-related harms. The prevalence of HED in Saint Vincent and the Grenadines (SVG) is 5.7% among the overall population aged 15 years and older and 10.2% among drinkers. Responsible Beverage Service interventions train alcohol servers to limit levels of intoxication attained by customers and decrease acute alcohol-related harms. The objectives of this study were to determine bar tenders' and rum shopkeepers' knowledge of and attitudes toward problem drinking and willingness to participate in server training...
April 28, 2018: Psychiatric Quarterly
https://www.readbyqxmd.com/read/29560630/-effect-of-electroacupuncture-at-neiguan-pc-6-on-serum-and-myocardial-metabolites-in-rats-with-myocardial-ischemia-reperfusion-injury-based-on-nuclear-magnetic-resonance-spectroscopy
#11
Ya-Ni Tang, Cheng-Fu Tan, Wei-Wei Liu, Jie Yan, Chao Wang, Mi Liu, Dong-Hai Lin, Cai-Hua Huang, Lin Du, Mei-Lin Chen, Jiao-Lan Li, Ding-Ming Zhu
OBJECTIVE: We have repeatedly demonstrated that electroacupuncture (EA) of "Neiguan"(PC 6) can improve myocardial ischemia in rats. The present study was designed to investigate the metabolomic profile of peripheral blood se-rum and myocardium involving EA-induced improvement of myocardial ischemia-reperfusion injury (MIRI) in rats by using nuclear magnetic resonance spectroscopy. METHODS: Thirty male SD rats were equally randomized into blank control, model and EA groups...
March 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29520358/usage-of-ft-icr-ms-metabolomics-for-characterizing-the-chemical-signatures-of-barrel-aged-whisky
#12
Chloé Roullier-Gall, Julie Signoret, Daniel Hemmler, Michael A Witting, Basem Kanawati, Bernhard Schäfer, Régis D Gougeon, Philippe Schmitt-Kopplin
Whisky can be described as a complex matrix integrating the chemical history from the fermented cereals, the wooden barrels, the specific distillery processes, aging, and environmental factors. In this study, using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) and liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS), we analyzed 150 whisky samples from 49 different distilleries, 7 countries, and ranging from 1 day new make spirit to 43 years of maturation with different types of barrel...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29519265/seasonality-of-helminth-infection-in-wild-red-deer-varies-between-individuals-and-between-parasite-taxa
#13
Gregory F Albery, Fiona Kenyon, Alison Morris, Sean Morris, Daniel H Nussey, Josephine M Pemberton
Parasitism in wild mammals can vary according to myriad intrinsic and extrinsic factors, many of which vary seasonally. However, seasonal variation in parasitism is rarely studied using repeated samples from known individuals. Here we used a wild population of individually recognized red deer (Cervus elaphus) on the Isle of Rum to quantify seasonality and intrinsic factors affecting gastrointestinal helminth parasitism over the course of a year. We collected 1020 non-invasive faecal samples from 328 known individuals which we then analysed for propagules of three helminth taxa: strongyle nematodes, the common liver fluke Fasciola hepatica and the tissue nematode Elaphostrongylus cervi...
March 9, 2018: Parasitology
https://www.readbyqxmd.com/read/29455529/differentiation-of-rums-produced-from-sugar-cane-juice-rhum-agricole-from-rums-manufactured-from-sugar-cane-molasses-by-a-metabolomics-approach
#14
Laura Franitza, Luca Nicolotti, Michael Granvogl, Peter Schieberle
A large set of volatiles (a metabolome) was isolated by SAFE distillation from 25 high priced rums prepared from sugar cane juice (SCJ) and 26 high priced rums manufactured from sugar cane molasses (SCM). The volatile fractions were first analyzed by comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry (GC×GC-TOF-MS), and the "comprehensive template matching fingerprinting" was used to extract the entire features present in the respective set of volatile compounds. After raw data pretreatment, chemometrics was used to locate marker compounds...
March 21, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29398841/plants-genotoxicity-as-pollution-bioindicator-in-jordan-using-comet-assay
#15
Wesam Al Khateeb
This study aimed to assess genotoxicity in wild plants grown in Jordan as a pollution bioindicator. Comet assay was used to evaluate the level of DNA damage in plants collected from different areas in Jordan. Significant differences in plant DNA damage index and frequency were observed among sites of collection. Results show that plants collected from Aqaba back road and Ghour Assaal had significantly higher damage values. In contrast, plants collected from Wadi Rum, Al Naqab Heights, Swaimeh/Deadsea and Alshoneh Aljanobyeh showed low levels of DNA damage...
February 2018: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/29396500/hepatocellular-carcinoma-targeting-oncolytic-adenovirus-overcomes-hypoxic-tumor-microenvironment-and-effectively-disperses-through-both-central-and-peripheral-tumor-regions
#16
A-Rum Yoon, JinWoo Hong, Minjung Kim, Chae-Ok Yun
Cancer-specific promoter driven replication of oncolytic adenovirus (Ad) is cancer-specific, but shows low transcriptional activity. Thus, we generated several chimeric α-fetoprotein (AFP) promoter variants, containing reconstituted enhancer and silencer regions, to preferentially drive Ad replication in hepatocellular carcinoma (HCC). Modified AFP promoter, containing 2 enhancer A regions and a single enhancer B region (a2bm), showed strong and HCC-specific transcription. In AFP-positive HCCs, gene expression was 43- to 456-fold higher than those of control AFP promoter lacking enhancers...
February 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29383896/-effect-of-acupuncture-on-inflammatory-cytokines-in-patients-with-acute-pelvic-inflammatory-disease
#17
Dan Wu, Li-Yan Guo, Pei-Si Lu
OBJECTIVE: To observe the effect of acupuncture on inflammatory indices and symptoms in patients with acute pelvic inflammatory disease, and investigate its mechanism. METHODS: Seventy-nine patients with acute pelvic inflammatory disease were randomly assigned to a control group ( n =37) given conventional treatment and an observation group ( n =42) given conventional treatment and acupuncture therapy. In the observation group, acupionts of Zhongji(CV 3), Guanyuan(CV 4), Zigong(EX-CA 1), Zusanli(ST 36), Sanyinjiao(SP 6), etc...
January 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29367604/covalent-isg15-conjugation-to-chip-promotes-its-ubiquitin-e3-ligase-activity-and-inhibits-lung-cancer-cell-growth-in-response-to-type-i-interferon
#18
Lang Yoo, A-Rum Yoon, Chae-Ok Yun, Kwang Chul Chung
The carboxyl terminus of Hsp70-interacting protein (CHIP) acts as a ubiquitin E3 ligase and a link between the chaperones Hsp70/90 and the proteasome system, playing a vital role in maintaining protein homeostasis. CHIP regulates a number of proteins involved in a myriad of physiological and pathological processes, but the underlying mechanism of action via posttranslational modification has not been extensively explored. In this study, we investigated a novel modulatory mode of CHIP and its effect on CHIP enzymatic activity...
January 24, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29316754/-detection-of-metals-and-metalloids-in-the-lavage-fluid-of-whole-lung-lavage-of-the-cases-of-pneumoconiosis
#19
K Wen, C G Ding, G Chen, G X Ma, H Q Wang
Objective: To detect of the components and concentration of the metals and metalloids in the lavage fluid of whole-lung lavage (WLL) of the cases of pneumoconiosis, and analyze the characteristics, and explore the method to sample and process the samples of bronchoalveolar lavage fluid (BAL) . Methods: The samples of urine and serum of three cases of pneumoconiosis were collected before WLL, and the samples of BAL were collected during the WLL from the left and right lungs according to the sequence of four pressured gas flow and five negative pressure drainage...
November 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29234498/evaluation-of-the-national-return-of-unwanted-medicines-rum-program-in-australia-a-study-protocol
#20
Amanda J Wheeler, Jean Spinks, Emilie Bettington, Fiona Kelly
Background: The National Return of Unwanted Medicines (NatRUM) program in Australia is one of the few nationally coordinated, free-to-consumer schemes to dispose of unwanted medicines globally. This scheme has been in operation since 1996, however, little is known about public awareness of the scheme and its effectiveness in reducing unsafe disposal practices. The study objectives are to undertake a review of (1) the current use of the NatRUM scheme by consumers; and (11) to investigate disposal practices and beliefs of the general population...
2017: Journal of Pharmaceutical Policy and Practice
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