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https://www.readbyqxmd.com/read/28546002/catechins-activate-muscle-stem-cells-by-myf5-induction-and-stimulate-muscle-regeneration
#1
A Rum Kim, Kyung Min Kim, Mi Ran Byun, Jun-Ha Hwang, Jung Il Park, Ho Taek Oh, Hyo Kyeong Kim, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Muscle weakness is one of the most common symptoms in aged individuals and increases risk of mortality. Thus, maintenance of muscle mass is important for inhibiting aging. In this study, we investigated the effect of catechins, polyphenol compounds in green tea, on muscle regeneration. We found that (-)-epicatechin gallate (ECG) and (-)-epigallocatechin-3-gallate (EGCG) activate satellite cells by induction of Myf5 transcription factors. For satellite cell activation, Akt kinase was significantly induced after ECG treatment and ECG-induced satellite cell activation was blocked in the presence of Akt inhibitor...
May 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28530407/a-gadolinium-complex-of-1-4-7-10-tetraazacyclododecane-1-4-7-trisacetic-acid-do3a-ethoxybenzyl-eob-conjugate-as-a-new-macrocyclic-hepatobiliary-mri-contrast-agent
#2
Ah Rum Baek, Hee-Kyung Kim, Subin Park, Gang Ho Lee, Hyo Jeung Kang, Jae Chang Jung, Joon-Suk Park, Hun-Kyu Ryeom, Tae-Jeong Kim, Yongmin Chang
We report the synthesis of a macrocyclic Gd chelate based on a 1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid (DO3A) coordination cage bearing an ethoxybenzyl (EOB) moiety and discuss its use as a T1 hepatobiliary magnetic resonance imaging (MRI) contrast agent. The new macrocyclic liver agent shows high chelation stability and high r1 relaxivity compared with linear-type Gd chelates, which are the current clinically approved liver agents. Our macrocyclic, liver-specific Gd chelate was evaluated in vivo through biodistribution analysis and liver MRI, which demonstrated its high tumor detection sensitivity and suggested that the new Gd complex is a promising contrast agent for liver cancer imaging...
May 22, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28449534/safety-profile-of-egfr-targeted-hybrid-vector-system-composed-of-pamam-dendrimer-and-oncolytic-adenovirus
#3
COMMENT
A-Rum Yoon, Dayananda Kasala, Jinwoo Hong, Chae-Ok Yun
No abstract text is available yet for this article.
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28434831/submuscular-versus-subcutaneous-ulnar-nerve-transposition-a-cadaveric-model-evaluating-their-role%C3%A2-in-primary-ulnar-nerve-repair-at-the-elbow
#4
Brandon S Smetana, Edward W Jernigan, Wayne A Rummings, Paul S Weinhold, Reid W Draeger, J Megan M Patterson
PURPOSE: To investigate the length gained from subcutaneous and submuscular transposition of the ulnar nerve at the elbow. Specifically, the study aimed to define an expected nerve gap able to be overcome, and to determine if a difference between transposition techniques exists. METHODS: Eleven cadaveric specimens from the scapula to fingertip were procured. In situ decompression and mobilization of the ulnar nerve at the elbow followed by simulated laceration of the nerve was performed...
April 20, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28398625/novel-creation-of-a-rum-flavor-lexicon-through-the-use-of-web-based-material
#5
Chelsea M Ickes, Soo-Yeun Lee, Keith R Cadwallader
Flavor lexicons help both manufacturers and consumers communicate the intricacies of flavor nuances they experience within a product. Lexicon development typically requires the use of a trained sensory panel to evaluate a representative sample set of the product category to generate terms that describe certain product attributes. In the case of rum, there is considerable variation in terms of style, flavor characteristics, and the sheer number of rums produced making it difficult to create a lexicon in this manner...
May 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28342344/water-hardness-determines-226-ra-uptake-in-the-tropical-freshwater-mussel
#6
Che Doering, Andreas Bollhöfer
Chemical data for freshwater mussels (Velesunio spp.) and water from 15 sampling sites in the Alligator Rivers Region and Rum Jungle uranium provinces in tropical Northern Australia were analysed to develop a predictive model of radium-226 ((226)Ra) bioaccumulation for variable water calcium (Ca) and magnesium (Mg) concentrations. Application of the model as a (226)Ra screening approach for freshwater mussels in tropical waterbodies potentially impacted by operational or remediated uranium mine sites is discussed in relation to Mudginberri Billabong, located approximately 12 km downstream of Ranger uranium mine in the Alligator Rivers Region...
June 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28315325/-epigallocatechin-3-gallate-stimulates-myogenic-differentiation-through-taz-activation
#7
A Rum Kim, Kyung Min Kim, Mi Ran Byun, Jun-Ha Hwang, Jung Il Park, Ho Taek Oh, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Muscle loss is a typical process of aging. Green tea consumption is known to slow down the progress of aging. Their underlying mechanisms, however, remain largely unknown. In this study, we investigated the effect of (-)-epigallocatechin-3-gallate (EGCG), a polyphenolic compound of green tea, on myogenic differentiation and found that EGCG significantly increases myogenic differentiation. After EGCG treatment, the expression of myogenic marker genes, such as myosin heavy chain, are increased through activation of TAZ, a transcriptional coactivator with a PDZ-binding motif...
April 29, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28259279/volar-anatomy-of-the-proximal-phalanx-implications-for-screw-length-selection-for-fixation-of-shaft-fractures
#8
P Barrett Honeycutt, Edward W Jernigan, Wayne A Rummings, Peter J Stern, Reid W Draeger
PURPOSE: To investigate the anatomy of the volar surface of the proximal phalanx of the hand, specifically the longitudinal groove running along the volar phalangeal shaft. METHODS: We measured skeletonized proximal phalanges from 10 embalmed human cadaver hands at 5 equidistant points along the shaft. The difference between the maximum dorsal-palmar thickness of the shaft and thickness measured from the center of the volar groove to the most dorsal aspect of the phalanx indicated the depth of the groove at each point...
March 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28214780/distress-intolerance-in-the-parents-of-substance-dependent-patients
#9
Suat Ekinci, Hanife Uğur Kural
The purpose of this study was to determine levels of Distress Tolerance (DT) and to compare levels of DT, depression, and anxiety in the parents of substance dependent patients. This sample included 40 parents of inpatients undergoing treatment for substance dependence (SDPP) in the Balıklı Rum Hospital, Istanbul, Turkey. A healthy control group was recruited of 40 individuals with no Axis I diagnoses that were counterbalanced with the SDPP group in terms of age and sex. All study participants completed a sociodemographic data form and the Beck Depression Inventory, the Beck Anxiety Inventory, the State & Trait Anxiety Inventory, and the Distress Tolerance Scale...
May 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28190943/sugar-sweetened-beverage-warning-labels-lessons-learned-from-the-tobacco-industry
#10
Lucy Popova
Tobacco warning labels effectively educate consumers about the harms of tobacco and reduce smoking behavior. Lessons from tobacco warning labels can be applied to developing and implementing warning labels for sugar-sweetened beverages (SSBs). Large pictorial rotating warnings are particularly effective. Dental professionals can be an important voice in countering the industry's efforts to create controversy around the effects of SSBs and in advocating for effective warning labels based on the evidence from the tobacco warning labels...
October 2016: Journal of the California Dental Association
https://www.readbyqxmd.com/read/28167315/modeling-of-un-deformed-chip-thickness-in-rum-process-and-study-of-size-effects-in-%C3%AE-rum
#11
Anil Kumar Jain, Pulak M Pandey
Un-deformed chip thickness is a critical parameter in machining processes. Measuring un-deformed chip thickness experimentally is a complicated process, especially in micro machining and may not even be measured accurately. The un-deformed chip thickness has an influence on material removal rate, cutting forces, specific energy and surface finish etc. In ceramic machining, it is also an indication of material removal mode such as ductile or brittle fracture. In the present study, an effort is made to model undeformed chip thickness, cutting forces and specific cutting energy in rotary ultrasonic machining (RUM) applied to the side milling operation...
May 2017: Ultrasonics
https://www.readbyqxmd.com/read/28123043/psychiatric-disorders-and-general-functioning-in-low-birth-weight-adults-a-longitudinal-study
#12
Astrid M W Lærum, Solveig Klæbo Reitan, Kari Anne I Evensen, Stian Lydersen, Ann-Mari Brubakk, Jon Skranes, Marit S Indredavik
OBJECTIVE: To examine psychiatric morbidity and overall functioning in adults born with low birth weight compared with normal birth weight controls at age 26 years and to study longitudinal trajectories of psychiatric morbidity from early adolescence to adulthood. METHODS: Prospective cohort study wherein 44 preterm very low birth weight (≤1500 g), 64 term small for gestational age (SGA; <10th percentile), and 81 control adults were examined using the MINI-International Neuropsychiatric Interview: M...
January 25, 2017: Pediatrics
https://www.readbyqxmd.com/read/28121172/cost-utility-analysis-of-cardiac-rehabilitation-after-conventional-heart-valve-surgery-versus-usual-care
#13
Tina Birgitte Hansen, Ann Dorthe Zwisler, Selina Kikkenborg Berg, Kirstine Lærum Sibilitz, Lau Caspar Thygesen, Jakob Kjellberg, Patrick Doherty, Neil Oldridge, Rikke Søgaard
Background While cardiac rehabilitation in patients with ischaemic heart disease and heart failure is considered cost-effective, this evidence may not be transferable to heart valve surgery patients. The aim of this study was to investigate the cost-effectiveness of cardiac rehabilitation following heart valve surgery. Design We conducted a cost-utility analysis based on a randomised controlled trial of 147 patients who had undergone heart valve surgery and were followed for 6 months. Methods Patients were randomised to cardiac rehabilitation consisting of 12 weeks of physical exercise training and monthly psycho-educational consultations or to usual care...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28060849/behavior-of-pigs-reared-in-enriched-environment-alternatives-to-extend-pigs-attention
#14
Simone Pereira Machado, Fabiana Ribeiro Caldara, Luciana Foppa, Rafael de Moura, Liliane Maria Piano Gonçalves, Rodrigo Garófallo Garcia, Irenilza de Alencar Nääs, Viviane Maria Oliveira Dos Santos Nieto, Geyssane Farias de Oliveira
Three trials were carried out in a completely randomized design aiming to assess the behavior of pigs in growth phase in enriched environments. Trial 1 evaluated the effects of frequency of availability of environmental enrichment. The animals were assigned to four treatments: 1) control with no enrichment object; 2) objects provided for six consecutive days uninterruptedly; 3) objects provided on alternate days, and 4) objects provided for six consecutive days taken away by the end of the afternoon and replaced at dawn...
2017: PloS One
https://www.readbyqxmd.com/read/28040629/a-mechanistic-ultrasonic-vibration-amplitude-model-during-rotary-ultrasonic-machining-of-cfrp-composites
#15
Fuda Ning, Hui Wang, Weilong Cong, P K S C Fernando
Rotary ultrasonic machining (RUM) has been investigated in machining of brittle, ductile, as well as composite materials. Ultrasonic vibration amplitude, as one of the most important input variables, affects almost all the output variables in RUM. Numerous investigations on measuring ultrasonic vibration amplitude without RUM machining have been reported. In recent years, ultrasonic vibration amplitude measurement with RUM of ductile materials has been investigated. It is found that the ultrasonic vibration amplitude with RUM was different from that without RUM under the same input variables...
December 18, 2016: Ultrasonics
https://www.readbyqxmd.com/read/27991965/popular-medicinal-uses-of-calea-uniflora-less-asteraceae-and-its-contribution-to-the-study-of-brazilian-medicinal-plants
#16
Luan S Ramos, Paula S Cardoso, Michele D Freitas, Renato Paghan, Marília S Borges, Vanilde Citadini-Zanette, James W Barlow, Patrícia A Amaral, Silvia Dalbó
Calea uniflora Less. is widely used in southern Santa Catarina (Brazil), but there are no scientific studies which support its use. Then, this study was proposed to determine of the percentage use of C. uniflora in a city of southern Brazil and documentation of the knowledge that the population has about this species. The survey was conducted with semi-structured interviews using a questionnaire applied to 372 participants. In analyzing the results, it was observed that of the 94.1% who recognized C. uniflora, 74...
October 2016: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/27905542/defining-an-olfactory-receptor-function-in-airway-smooth-muscle-cells
#17
William H Aisenberg, Jessie Huang, Wanqu Zhu, Premraj Rajkumar, Randy Cruz, Lakshmi Santhanam, Niranjana Natarajan, Hwan Mee Yong, Breann De Santiago, Jung Jin Oh, A-Rum Yoon, Reynold A Panettieri, Oliver Homann, John K Sullivan, Stephen B Liggett, Jennifer L Pluznick, Steven S An
Pathways that control, or can be exploited to alter, the increase in airway smooth muscle (ASM) mass and cellular remodeling that occur in asthma are not well defined. Here we report the expression of odorant receptors (ORs) belonging to the superfamily of G-protein coupled receptors (GPCRs), as well as the canonical olfaction machinery (Golf and AC3) in the smooth muscle of human bronchi. In primary cultures of isolated human ASM, we identified mRNA expression for multiple ORs. Strikingly, OR51E2 was the most highly enriched OR transcript mapped to the human olfactome in lung-resident cells...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27873566/pathological-and-phylogenetic-characterization-of-amphibiothecum-sp-infection-in-an-isolated-amphibian-lissotriton-helveticus-population-on-the-island-of-rum-scotland
#18
Caterina Fiegna, Charlotte L Clarke, Darren J Shaw, Johanna L Baily, Frances C Clare, Alexandra Gray, Trenton W J Garner, Anna L Meredith
Outbreaks of cutaneous infectious disease in amphibians are increasingly being attributed to an overlooked group of fungal-like pathogens, the Dermocystids. During the last 10 years on the Isle of Rum, Scotland, palmate newts (Lissotriton helveticus) have been reportedly afflicted by unusual skin lesions. Here we present pathological and molecular findings confirming that the pathogen associated with these lesions is a novel organism of the order Dermocystida, and represents the first formally reported, and potentially lethal, case of amphibian Dermocystid infection in the UK...
November 22, 2016: Parasitology
https://www.readbyqxmd.com/read/27832324/secretin-stimulated-mri-assessment-of-exocrine-pancreatic-function-in-patients-with-cystic-fibrosis-and-healthy-controls
#19
Adnan Madzak, Trond Engjom, Gaute K Wathle, Søren Schou Olesen, Erling Tjora, Pål R Njølstad, Birger Norderud Lærum, Asbjørn Mohr Drewes, Georg Dimcevski, Jens Brøndum Frøkjær, Ingfrid S Haldorsen
PURPOSE: Secretin-stimulated magnetic resonance imaging (s-MRI) and pancreatic diffusion weighted imaging (DWI) are novel non-invasive imaging techniques for assessment of exocrine pancreatic insufficiency (EPI). The aim was to validate s-MRI assessed pancreatic secreted volume using novel semi-automatic quantification software, and to assess the ability of s-MRI with DWI to diagnose EPI in patients with cystic fibrosis (CF). METHODS: s-MRI and DWI was performed in 19 patients with CF (median age 21 years; range 16-56; eight men) and in 10 healthy controls (HC) (median age 46 years; range 20-65; four men)...
November 10, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27823683/cardiac-rehabilitation-versus-usual-care-for-patients-treated-with-catheter-ablation-for-atrial-fibrillation-results-of-the-randomized-copenheartrfa-trial
#20
RANDOMIZED CONTROLLED TRIAL
Signe S Risom, Ann-Dorthe Zwisler, Trine B Rasmussen, Kirstine Lærum Sibilitz, Trine L S Madsen, Jesper Hastrup Svendsen, Christian Gluud, Jane Lindschou, Per Winkel, Selina Kikkenborg Berg
BACKGROUND: To assess the effects of comprehensive cardiac rehabilitation compared with usual care on physical activity and mental health for patients treated with catheter ablation for atrial fibrillation. METHODS: The patients were randomized 1:1 stratified by paroxysmal or persistent atrial fibrillation and sex to cardiac rehabilitation consisting of 12 weeks physical exercise and four psycho-educational consultations plus usual care (cardiac rehabilitation group) versus usual care...
November 2016: American Heart Journal
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