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JOURNAL ARTICLE
Sara Mazzucco, Linxin Li, Maria Assuncao Tuna, Peter M Rothwell
INTRODUCTION: Cerebral blood flow (CBF) declines with age and abnormalities in CBF are associated with age-related cerebrovascular disease and neurodegeneration. Women have higher CBF than men, although this sex-difference diminishes to some extent with age in healthy subjects. The physiological drivers of these age/sex differences are uncertain, but might be secondary to age and sex-differences in haemoglobin (Hb) level. Hb levels are inversely correlated with CBF, are lower in women, and decline with age in men, but the interrelations between these factors have not been explored systematically either in healthy subjects or across the full age-range in patients with vascular risk factors...
April 18, 2024: European Stroke Journal
#2
Sanvitti Bengeri, Lauren Safiya Mark, Oluwaseemo Ayomide Osomo, Wilhelm Kuker, Gabriel Sc Yiin
A 57-year-old man presented to the emergency department following a road traffic accident, having experienced a sudden ascending 'wave of emotion'. After the event, he developed an intense right-sided temporal headache and was thought to have a complex grief reaction resulting from a recent bereavement. Given persistent symptoms, a computed tomography (CT) scan of head was conducted at an outpatient transient ischaemic attack (TIA) clinic, which showed a possible right occipital infarct. Further magnetic resonance imaging (MRI) scanning revealed instead a segmental area of microbleeds in the posterior right temporal lobe, with occipital extension...
September 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
#3
JOURNAL ARTICLE
Yan Shi, Fahad Mir, Isuru Induruwa, Kayvan Khadjooi
No abstract text is available yet for this article.
November 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
#4
RANDOMIZED CONTROLLED TRIAL
Maya H Buch, Deepak L Bhatt, Christina Charles-Schoeman, Jon T Giles, Ted Mikuls, Gary G Koch, Steven Ytterberg, Edward Nagy, Hyejin Jo, Kenneth Kwok, Carol A Connell, Karim Richard Masri, Arne Yndestad
OBJECTIVES: Compare the risk of extended major adverse cardiovascular (CV) event (MACE) composite outcomes and component events in patients with rheumatoid arthritis (RA) treated with tofacitinib versus tumour necrosis factor inhibitors (TNFi) in Oral Rheumatoid Arthritis Trial (ORAL) Surveillance. METHODS: Patients with RA aged ≥50 years and with ≥1 additional CV risk factor received tofacitinib 5 mg or 10 mg two times per day or TNFi...
April 12, 2024: RMD Open
#5
JOURNAL ARTICLE
Isabel Siow, Kaavya Narasimhalu, Keng Siang Lee, Hong Kuang Tan, Simon Kang Seng Ting, Shahul Hameed, Hui Meng Chang, Deidre Anne De Silva, Christopher Li Hsian Chen, Eng King Tan
INTRODUCTION: Post stroke cognitive impairment (PSCI) is a common complication of ischemic stroke. PSCI can involve different depending on clinical and stroke related characteristics. The aim of this study is to determine the factors associated with impairments in specific cognitive domains. METHODS: The Vitamins to Prevent Stroke (VITATOPS) trial is a large, multinational randomised controlled trial. In this substudy, consecutive patients admitted for ischaemic stroke or transient ischaemic attack (TIA) at a tertiary hospital in Singapore were included...
April 9, 2024: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#6
JOURNAL ARTICLE
Johan O Wedin, Sergey Rodin, Frank A Flachskampf, Oscar E Simonson, Johan Pallin, Jonathan Hörsne Malmborg, Stefan K James, Elisabeth Ståhle, Karl-Henrik Grinnemo
AIMS: To investigate (i) the association between pre-operative left atrial (LA) reservoir strain and post-operative atrial fibrillation (AF) and (ii) the incidence of post-operative ischaemic stroke events separately in bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV) patients after surgical aortic valve replacement for isolated severe aortic stenosis (AS). METHODS AND RESULTS: We prospectively enrolled 227 patients ( n = 133 BAV and n = 94 TAV) with isolated severe AS scheduled for aortic valve replacement...
March 2024: Eur Heart J Open
#7
JOURNAL ARTICLE
Alberto Bramucci, Roberto Nerla, Claudio Bianchini Massoni, Davide Giovannini, Johanna Chester, Antonio Freyrie, Fausto Castriota
BACKGROUND: Technological and surgical approaches to carotid artery stenting (CAS) have evolved. Modern randomised controlled trials comparing CAS and carotid endarterectomy (CEA) are limited, and information about updated post-intervention outcomes are mostly from retrospective, small studies. AIMS: This study aims to compare the 30-day outcomes of stroke, transient ischaemic attack (TIA), acute myocardial infarction (AMI) and death with propensity-matched groups of CEA and CAS in asymptomatic and symptomatic patients over a recent study period of new CAS technologies and approaches...
April 1, 2024: EuroIntervention
#8
JOURNAL ARTICLE
Matthew Anson, Alex E Henney, Sizheng S Zhao, Gema H Ibarburu, Gregory Y H Lip, Daniel J Cuthbertson, Katarzyna Nabrdalik, Uazman Alam
AIMS: To evaluate the efficacy and cardiovascular outcomes of combination pioglitazone with either a glucagon-like peptide-1 receptor agonist (GLP-1RA) or a sodium-glucose cotransporter-2 (SGLT2) inhibitor in individuals with type 2 diabetes (T2D) by conducting a systematic review, meta-analysis, and analysis of a large international real-world database. METHODS: We searched MEDLINE, SCOPUS and Web of Science to identify relevant articles for inclusion (PROSPERO [CRD: 42023483126])...
April 1, 2024: Diabetes, Obesity & Metabolism
#9
JOURNAL ARTICLE
Derk Frank, Eric Durand, Sandra Lauck, Douglas F Muir, Mark Spence, Mariuca Vasa-Nicotera, David Wood, Francesco Saia, Cristóbal A Urbano-Carrillo, Damien Bouchayer, Vlad Anton Iliescu, Christophe Saint Etienne, Florence Leclercq, Vincent Auffret, Lluis Asmarats, Carlo Di Mario, Aurelie Veugeois, Jiri Maly, Andreas Schober, Luis Nombela-Franco, Nikos Werner, Joan Antoni Gómez-Hospital, Julia Mascherbauer, Giuseppe Musumeci, Nicolas Meneveau, Thibaud Meurice, Felix Mahfoud, Federico De Marco, Tim Seidler, Florian Leuschner, Patrick Joly, Jean-Philippe Collet, Ferdinand Vogt, Emilio Di Lorenzo, Elmar Kuhn, Vicente Peral Disdier, Violetta Hachaturyan, Claudia M Lüske, Radka Rakova, Wilbert Wesselink, Jana Kurucova, Peter Bramlage, Gemma McCalmont
BACKGROUND AND AIMS: There is significant potential to streamline the clinical pathway for patients undergoing transcatheter aortic valve implantation (TAVI). The purpose of this study was to evaluate the effect of implementing BENCHMARK best practices on the efficiency and safety of TAVI in 28 sites in 7 European countries. METHODS: This was a study of patients with severe symptomatic aortic stenosis (AS) undergoing TAVI with balloon-expandable valves before and after implementation of BENCHMARK best practices...
March 30, 2024: European Heart Journal
#10
JOURNAL ARTICLE
Pedro Cougo, Heber Colares, João Gabriel Farinhas, Mariana Hämmerle, Pedro Neves, Raquel Bezerra, Alex Balduino, Ona Wu, Octavio M Pontes-Neto
Leukoaraiosis is a neuroimaging marker of small-vessel disease that is characterized by high signal intensity on fluid-attenuated inversion recovery MRI. There is increasing evidence from pathology and neuroimaging suggesting that the structural abnormalities that characterize leukoaraiosis are actually present within regions of normal-appearing white matter, and that the underlying pathophysiology of white matter damage related to small-vessel disease involves blood-brain barrier damage. In this study, we aim to verify whether leukoaraiosis is associated with elevated signal intensity on fluid-attenuated inversion recovery imaging, a marker of brain tissue free-water accumulation, in normal-appearing white matter...
2024: Brain communications
#11
Josephine McCarthy, Mitchell Munnings, Benjamin Clissold, Peter J Fuller, Jun Yang, Thanh G Phan
BACKGROUND AND PURPOSE: Primary aldosteronism (PA) is the most common endocrine cause of secondary hypertension with a prevalence of 14% in patients with newly diagnosed hypertension. Patients with PA experience a higher rate of cardiovascular events including stroke when compared to those with blood pressure matched essential hypertension. This systematic review and meta-analysis summarize current evidence on the prevalence of PA in patients with acute stroke or transient ischemic attack (TIA)...
2024: Frontiers in Endocrinology
#12
JOURNAL ARTICLE
Edel Burton, Rory Quinn, Kieran Crosbie-Staunton, Conor Deasy, Siobhan Masterson, Cathal O'Donnell, Áine Merwick, David Willis, Patricia M Kearney, Vera J C Mc Carthy, Claire M Buckley
OBJECTIVES: Time is a fundamental component of acute stroke and transient ischaemic attack (TIA) care, thus minimising prehospital delays is a crucial part of the stroke chain of survival. COVID-19 restrictions were introduced in Ireland in response to the pandemic, which resulted in major societal changes. However, current research on the effects of the COVID-19 pandemic on prehospital care for stroke/TIA is limited to early COVID-19 waves. Thus, we aimed to investigate the effect of the COVID-19 pandemic on ambulance time intervals and suspected stroke/TIA call volume for adults with suspected stroke and TIA in Ireland, from 2018 to 2021...
March 20, 2024: BMJ Open
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JOURNAL ARTICLE
Rohit Bhatia, M V Padma Srivastava, Risha Sarkar, Saman Fatima, Imnameren Longkumer, Ajay Garg, Pooja Gupta, Jeyaraj Durai Pandian, Dheeraj Khurana, P N Sylaja, Shweta Jain, Deepti Arora, Aneesh Dhasan, Meenakshi Sharma
RATIONALE: Intracranial atherosclerotic disease (ICAD) is a pathological process that causes progressive stenosis and cerebral hypoperfusion, leading to stroke occurrence and recurrence around the world. The exact duration of dual antiplatelet therapy (DAPT) for ICAD is unclear in view of long-term risk of bleeding complications. AIM: The current study aims to study the efficacy and safety of long-term DAPT (up to 12 months) in patients with ICAD. SAMPLE SIZE: Using 80% power and an alpha error of 5 %, presuming a 10%-15% drop-out rate, a total of 2200 patients will be recruited for the study...
2024: BMJ neurology open
#14
JOURNAL ARTICLE
Benjamin De Becker, Milad El Haddad, Maarten De Smet, Clara François, Rene Tavernier, Jean-Benoit le Polain de Waroux, Sébastien Knecht, Mattias Duytschaever
AIMS: Pulsed field ablation (PFA) is a promising ablation technique for pulmonary vein isolation (PVI) with appealing advantages over radiofrequency (RF) including speed, tissue selectivity, and the promise of enhanced durability. In this study, we determine the procedural performance, efficacy, safety, and durability of PFA and compare its performance with a dataset of optimized RF ablation. METHODS AND RESULTS: After propensity score matching, we compared 161 patients who received optimized RF-guided PVI in the PowerPlus study (CLOSE protocol) with 161 patients undergoing PFA-guided PVI for paroxysmal or persistent atrial fibrillation (AF; pentaspline basket catheter)...
March 2024: Eur Heart J Open
#15
JOURNAL ARTICLE
Akash Fichadiya, Amity Quinn, Flora Au, Dennis Campbell, Darren Lau, Paul Ronksley, Reed Beall, David J T Campbell, Stephen B Wilton, Derek S Chew
AIMS: Prior studies suggest that sodium-glucose cotransporter-2 inhibitors (SGLT2is) may decrease the incidence of atrial fibrillation (AF). However, it is unknown whether SGLT2i can attenuate the disease course of AF among patients with pre-existing AF and Type II diabetes mellitus (DM). In this study, our objective was to examine the association between SGLT2i prescription and arrhythmic outcomes among patients with DM and pre-existing AF. METHODS AND RESULTS: We conducted a population-based cohort study of adults with DM and AF between 2014 and 2019...
March 1, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
#16
JOURNAL ARTICLE
Ruth Geraldes, Monica Santos, Cristina Ponte, Anthea Craven, Lillian Barra, Joanna C Robson, Nevin Hammam, Jason Springer, Jöerg Henes, Alojzija Hocevar, Jukka Putaala, Ernestina Santos, Liza Rajasekhar, Thomas Daikeler, Omer Karadag, Andreia Costa, Nader Khalidi, Christian Pagnoux, Patrícia Canhão, Teresa Pinho E Melo, Ana Catarina Fonseca, José M Ferro, João Eurico Fonseca, Ravi Suppiah, Richard A Watts, Peter Grayson, Peter A Merkel, Raashid A Luqmani
OBJECTIVES: The cerebral vessels may be affected in primary systemic vasculitis (PSV), but little is known about cerebrovascular events (CVEs) in this population. This study aimed to determine the frequency of CVEs at the time of diagnosis of PSV, to identify factors associated with CVEs in PSV, and to explore features and outcomes of stroke in patients with PSV. METHODS: Data from adults newly diagnosed with PSV within the Diagnostic and Classification Criteria in VASculitis (DCVAS) study were analysed...
March 12, 2024: Journal of Neurology
#17
JOURNAL ARTICLE
Óscar González-Lorenzo, Juan A Franco Pelaez, Andrea Kallmeyer, Luis Nieto, Laura Esteban, Ana Pello, Álvaro Aceña, Gonzalo Aldamiz, José Tuñón
INTRODUCTION: The presence of non-coronary atherosclerosis (NCA) in patients with coronary artery disease is associated with a poor prognosis. We have studied whether NCA is also a predictor of poorer outcomes in patients undergoing coronary artery bypass grafting (CABG). MATERIALS AND METHODS: This is an observational study involving 567 consecutive patients who underwent CABG. Variables and prognosis were analysed based on the presence or absence of NCA, defined as previous stroke, transient ischaemic attack (TIA), or peripheral artery disease (PAD) [lower extremity artery disease (LEAD), carotid disease, previous lower limb vascular surgery, or abdominal aortic aneurysm (AAA)]...
2024: Frontiers in Cardiovascular Medicine
#18
JOURNAL ARTICLE
Si-Meng Liu, Gan Gao, Fang-Bin Hao, Shi-Tong Liu, Ri-Miao Yang, Hou-di Zhang, Min-Jie Wang, Zheng-Xing Zou, Dan Yu, Qian Zhang, Qing-Bao Guo, Xiao-Peng Wang, He-Guan Fu, Jing-Jie Li, Cong Han, Lian Duan
BACKGROUND: The relationship between anterior cerebral artery (ACA) occlusion and moyamoya disease (MMD) has rarely been studied. In this study, we focused on a special type of MMD: isolated ACA-occlusive MMD. We investigated clinical attributes, genotypes and progression risk factors in patients with ACA-occlusive MMD, providing initial insights into the relationship between ACA occlusion and MMD. METHODS: We retrospectively analysed digital subtraction angiography (DSA) from 2486 patients and diagnosed 139 patients with ACA-occlusive MMD...
March 9, 2024: Stroke and Vascular Neurology
#19
JOURNAL ARTICLE
Kiran Bam, Monique F Kilkenny, Joosup Kim, Dominique A Cadilhac, Christopher Pearce, Nadine E Andrew, Lauren Sanders, Amanda G Thrift, Mark R Nelson, Seana Gall, Galina Daraganova, Muideen T Olaiya
INTRODUCTION: There is limited evidence about the management of cardiovascular risk factors within 12 months before stroke/transient ischaemic attack (TIA) in Australian general practices. We evaluated whether age and sex disparities in cardiovascular risk factor management for primary prevention exist in general practice. METHODS: A retrospective cohort study using data from the Australian Stroke Clinical Registry (2014-2018) linked with general practice data from three primary health networks in Victoria, Australia...
March 6, 2024: Neuroepidemiology
#20
JOURNAL ARTICLE
Sang Jun Lee, Junbeom Park, Jin-Kyu Park, Ki-Woon Kang, Jaemin Shim, Eue-Keun Choi, Jun Kim, Jin-Bae Kim, Young Soo Lee, Hyung Wook Park, Boyoung Joung
The presence of symptoms plays an important role in determining whether to focus on rhythm control or rate control when treating atrial fibrillation (AF). Previous comparative studies on the clinical outcomes of symptomatic and asymptomatic AF have yielded inconsistent results, and a link between AF symptoms and left atrial (LA) remodeling is not established. Patients selected from the COmparison study of Drugs for symptom control and complication prEvention of AF (CODE-AF) registry, which is a prospective, multicenter study consisting of patients with non-valvular AF, were grouped into 2 groups: symptomatic and asymptomatic...
March 1, 2024: American Journal of Cardiology
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