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https://www.readbyqxmd.com/read/27800606/promoting-cancer-control-in-africa-with-ubuntu-a-report-of-the-african-organization-for-research-and-training-in-africa-aortic-10-th-conference-2015-in-marrakech-morocco
#1
Kenneth O Simbiri, Christopher K Williams, Marcella Macaluso, Antonio Giordano
The objectives of the African Organization for Research and Training in Cancer (AORTIC), includes bringing products of decades of advances in cancer research to African populations through local and international collaboration. The consistent and huge growth in participation in the conferences and the diversity of the nations is a witness to the success of the organization thus far. The theme for the Tenth AORTIC International Conference on Cancer in Africa in Morocco in 2015 was "Road map to Cancer Control in Africa" and topics of discussion of paramount importance for low- and middle-income African countries included childhood cancers such as BL, cancers of the cervix, breast, and prostate; cancers associated with HIV-infection such as cervical, vulvar, and anal; as well as cancer care challenges associated with palliative care...
November 1, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27311602/regenerative-medicine-provides-alternative-strategies-for-the-treatment-of-anal-incontinence
#2
Søren Gräs, Cæcilie Krogsgaard Tolstrup, Gunnar Lose
INTRODUCTION AND HYPOTHESIS: Anal incontinence is a common disorder but current treatment modalities are not ideal and the development of new treatments is needed. The aim of this review was to identify the existing knowledge of regenerative medicine strategies in the form of cellular therapies or bioengineering as a treatment for anal incontinence caused by anal sphincter defects. METHODS: PubMed was searched for preclinical and clinical studies in English published from January 2005 to January 2016...
June 16, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/26559167/systematic-review-of-guidelines-for-the-assessment-and-management-of-high-grade-anal-intraepithelial-neoplasia-ain%C3%A2-ii-iii
#3
REVIEW
N N Alam, D A White, S K Narang, I R Daniels, N J Smart
AIM: There is ambiguity with regard to the optimal management of anal intraepithelial neoplasia (AIN) III. The aim of this review was to assess and compare international/national society guidelines currently available in the literature on the management, treatment and surveillance of AIN III. We also aimed to assess the quality of the studies used to compile the guidelines and to clarify the terminology used in histological assessment. METHOD: An electronic search of PubMed and Embase was performed using the search terms 'anal intraepithelial neoplasia', 'AIN', 'anal cancer', 'guidelines', 'surveillance' and 'management'...
February 2016: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/26151053/2d-dige-does-not-reveal-all-a-scotopic-report-suggests-differential-expression-of-a-single-calponin-family-member-protein-for-tetany-of-sphincters
#4
REVIEW
Arun Chaudhury
Using 2D differential gel electrophoresis (DIGE) and mass spectrometry (MS), a recent report by Rattan and Ali (2015) compared proteome expression between tonically contracted sphincteric smooth muscles of the internal anal sphincter (IAS), in comparison to the adjacent rectum [rectal smooth muscles (RSM)] that contracts in a phasic fashion. The study showed the differential expression of a single 23 kDa protein SM22, which was 1.87 fold, overexpressed in RSM in comparison to IAS. Earlier studies have shown differences in expression of different proteins like Rho-associated protein kinase II, myosin light chain kinase, myosin phosphatase, and protein kinase C between IAS and RSM...
2015: Frontiers in Medicine
https://www.readbyqxmd.com/read/26102113/-letters-to-the-editor-published-in-peruvian-biomedical-journals-indexed-in-scielo-peru-2006-2013
#5
Juan José Montenegro-Idrogo, Jhon William Mejía-Dolores, Joel L Chalco-Huamán
This bibliometric study describes the characteristics of letters to the editor published between 2006-2013 in biomedical journals indexed in SciELO-Peru.253 letters (10.3% of total publications) were collected. Most letters (139) were in the Peruvian Journal of Experimental Medicine and Public Health, with marked increase throughout those years. 25% of letters submitted included medical student participation. 14% of authors presented with international affiliations and 27% with endogenous affiliation - common in university journals (Anales de la Facultad de Medicina, Revista Médica Herediana)...
January 2015: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/25830422/a-randomized-trial-of-laparoscopic-versus-open-surgery-for-rectal-cancer
#6
RANDOMIZED CONTROLLED TRIAL
H Jaap Bonjer, Charlotte L Deijen, Gabor A Abis, Miguel A Cuesta, Martijn H G M van der Pas, Elly S M de Lange-de Klerk, Antonio M Lacy, Willem A Bemelman, John Andersson, Eva Angenete, Jacob Rosenberg, Alois Fuerst, Eva Haglind
BACKGROUND: Laparoscopic resection of colorectal cancer is widely used. However, robust evidence to conclude that laparoscopic surgery and open surgery have similar outcomes in rectal cancer is lacking. A trial was designed to compare 3-year rates of cancer recurrence in the pelvic or perineal area (locoregional recurrence) and survival after laparoscopic and open resection of rectal cancer. METHODS: In this international trial conducted in 30 hospitals, we randomly assigned patients with a solitary adenocarcinoma of the rectum within 15 cm of the anal verge, not invading adjacent tissues, and without distant metastases to undergo either laparoscopic or open surgery in a 2:1 ratio...
April 2, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/25391392/anal-fissure-chronic
#7
Richard L Nelson
INTRODUCTION: Anal fissures are a common cause of anal pain during, and for 1 to 2 hours after, defecation. The cause is not fully understood, but low intake of dietary fibre may be a risk factor. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical question: What are the effects of surgical treatments for chronic anal fissure? We searched: Medline, Embase, The Cochrane Library, and other important databases up to January 2014 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review)...
November 12, 2014: Clinical Evidence
https://www.readbyqxmd.com/read/25305752/update-on-the-management-of-anal-fissure
#8
REVIEW
T Higuero
Anal fissure is an ulceration of the anoderm in the anal canal. Its pathogenesis is due to multiple factors: mechanical trauma, sphincter spasm, and ischemia. Treatment must address these causative factors. While American and British scientific societies have published recommendations, there is no formal treatment consensus in France. Medical treatment is non-specific, aimed at softening the stool and facilitating regular bowel movements; this results in healing of almost 50% of acute anal fissures. The risk of recurrent fissure remains high if the causative factors persist...
April 2015: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/25283533/anatomy-of-sex-revision-of-the-new-anatomical-terms-used-for-the-clitoris-and-the-female-orgasm-by-sexologists
#9
REVIEW
Vincenzo Puppo, Giulia Puppo
Sexual medicine experts and sexologists must spread certainties on the biological basis of the female orgasm to all women, not hypotheses or personal opinions. Therefore, they must use scientific anatomical terminology. The anatomy of the clitoris and the female orgasm are described in textbooks, but some researchers have proposed a new anatomical terminology for the sexual response in women. The internal/inner clitoris does not exist: the entire clitoris is an external organ. The clitoris is not composed of two arcs but of the glans, body, and crura or roots...
April 2015: Clinical Anatomy
https://www.readbyqxmd.com/read/24736539/-the-experience-of-treatment-with-medicines-of-botulinum-toxin-of-type-a-lantox-of-chronic-anal-fissure-with-sphincter-spasm
#10
I I Gribanov
The original material of monitoring of 118 patients with chronic anal fissure is presented in the article. Patients' mean age was 48.9+-10.5 years. It was used injections of medicine of botulinum toxin of type A (Lantox) by its introduction in internal anal sphincter in all patients. There was granulating wound with signs of marginal epithelialization in 59.3% of cases on the 10th day after injection. It was detected complete epithelialization of dermis defect in 93.2% of cases on the 21st day, after six weeks - in 100% of cases...
2014: Khirurgiia
https://www.readbyqxmd.com/read/24684042/current-concepts-of-pathophysiology-epidemiology-and-classification-of-pruritus
#11
REVIEW
Marina Jovanović
Discovery of pruritus-specific mediators and receptors facilitated the neurobiological concept of pruritus: itch-specific (histamine-dependent and histamine-independent C-fibers); itch-specific receptors on cutaneous and spinal neurons; "dialogue" between the pruritus-specific neurons and cells in the skin; peripheral and central mediation of pruritus; functional "pruritus-specific matrix" in the brain with a role of pruritus center. In 10%-50% of persons without skin diseases, pruritus is considered the manifestation of a systemic disorder...
January 2014: Srpski Arhiv za Celokupno Lekarstvo
https://www.readbyqxmd.com/read/24668156/biofeedback-for-treatment-of-chronic-idiopathic-constipation-in-adults
#12
REVIEW
Sue Woodward, Christine Norton, Pauline Chiarelli
BACKGROUND: Biofeedback therapy has been used to treat the symptoms of people with chronic constipation referred to specialist services within secondary and tertiary care settings. However, different methods of biofeedback are used within different centres and the magnitude of suggested benefits and comparable effectiveness of different methods of biofeedback has yet to be established. OBJECTIVES: To determine the efficacy and safety of biofeedback for the treatment of chronic idiopathic (functional) constipation in adults...
2014: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/24582493/perianal-implantation-of-bioengineered-human-internal-anal-sphincter-constructs-intrinsically-innervated-with-human-neural-progenitor-cells
#13
Shreya Raghavan, Eiichi A Miyasaka, Robert R Gilmont, Sita Somara, Daniel H Teitelbaum, Khalil N Bitar
BACKGROUND: The internal anal sphincter (IAS) is a major contributing factor to pressure within the anal canal and is required for maintenance of rectoanal continence. IAS damage or weakening results in fecal incontinence. We have demonstrated that bioengineered, intrinsically innervated, human IAS tissue replacements possess key aspects of IAS physiology, such as the generation of spontaneous basal tone and contraction/relaxation in response to neurotransmitters. The objective of this study is to demonstrate the feasibility of implantation of bioengineered IAS constructs in the perianal region of athymic rats...
April 2014: Surgery
https://www.readbyqxmd.com/read/24574754/epidemiological-and-clinical-characteristics-of-inflammatory-bowel-diseases-in-cairo-egypt
#14
Serag Esmat, Mohamed El Nady, Mohamed Elfekki, Yehia Elsherif, Mazen Naga
AIM: To study the natural history, patterns and clinical characteristics of inflammatory bowel diseases (IBD) in Egypt. METHODS: We designed a case-series study in the gastroenterology centre of the Internal Medicine department of Cairo University, which is a tertiary care referral centre in Egypt. We included all patients in whom the diagnosis of ulcerative colitis (UC) or Crohn's disease (CD) was confirmed by clinical, laboratory, endoscopic, histological and/or radiological criteria over the 15 year period from 1995 to 2009, and we studied their sociodemographic and clinical characteristics...
January 21, 2014: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/24328537/bioengineering-of-physiologically-functional-intrinsically-innervated-human-internal-anal-sphincter-constructs
#15
Robert R Gilmont, Shreya Raghavan, Sita Somara, Khalil N Bitar
Muscle replacement for patients suffering from extensive tissue loss or dysfunction is a major objective of regenerative medicine. To achieve functional status, bioengineered muscle replacement constructs require innervation. Here we describe a method to bioengineer functionally innervated gut smooth muscle constructs using neuronal progenitor cells and smooth muscle cells isolated and cultured from intestinal tissues of adult human donors. These constructs expressed markers for contractile smooth muscle, glial cells, and mature neuronal populations...
June 2014: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/23875060/endobronchial-metastasis-from-primary-anorectal-melanoma
#16
Benjamin M Heyman, Matthew M Chung, Amy L Lark, Scott Shofer
PATIENT: Male, 64 FINAL DIAGNOSIS: Metastatic anorectal melanoma with endotracheal metastasis Symptoms: Fatigue • weight loss • hematochezia • cough MEDICATION: None Clinical Procedure: Biopsy of anal mass • rigid bronchoscopy Specialty: Internal medicine • oncology • pulmonology. OBJECTIVE: Rare disease. BACKGROUND: Anorectal melanoma is a rare cancer with a poor prognosis. The mean survival after diagnosis is 15-25 months...
2013: American Journal of Case Reports
https://www.readbyqxmd.com/read/23872488/a-new-era-endoscopic-tissue-transplantation
#17
REVIEW
Cadman L Leggett, Emmanuel C Gorospe, Lori Lutzke, Marlys Anderson, Kenneth K Wang
PURPOSE OF REVIEW: To describe basic principles of tissue engineering with emphasis on the potential role of gastrointestinal endoscopy in regenerative medicine. RECENT FINDINGS: Stricturing associated with endoscopic submucosal resection and circumferential endoscopic mucosal resection can be prevented through transplantation of autologous epidermal cell sheets or seeded decellularized biological scaffolds. Lower esophageal sphincter augmentation through injection of muscle-derived cells is a novel potential treatment for gastroesophageal reflux disease...
September 2013: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/23706564/a-novel-animal-model-of-long-term-sustainable-anal-sphincter-dysfunction
#18
COMPARATIVE STUDY
Izumi Yamaguchi, Fumihiko Fujita, Kosho Yamanouchi, Takehiro Mishima, Daisuke Kawahara, Yusuke Sakai, Shinichiro Ito, Kengo Kanetaka, Mitsuhisa Takatsuki, Tamotsu Kuroki, Susumu Eguchi
BACKGROUND: Although intersphincteric resection can avoid the need for permanent colostomy in patients with lower rectal cancer, it sometimes causes anal sphincter dysfunction, thus resulting in a lifelong, debilitating disorder due to incontinence of solid and liquid stool. The development of regenerative medicine could improve this condition by regenerating impaired anal muscle. In order to prove this hypothesis, preliminary experiments in animals will be indispensable; however, an adequate animal model is currently lacking...
October 2013: Journal of Surgical Research
https://www.readbyqxmd.com/read/23480355/development-of-the-human-tail-bud-and-splanchnic-mesenchyme
#19
Ryozo Hashimoto
The purpose of this paper was to shed some light on anorectal development from a viewpoint of the tail bud and splanchnic mesenchyme for better understanding of the morphogenesis of the human anorectum. Human embryos ranging from Carnegie stage 11 to 23 (CS 11 to 23) were adopted in this study. Seventeen embryos preserved at the Congenital Anomaly Research Center of Kyoto University Graduate School of Medicine were histologically examined. The cloaca, extending caudally to the hindgut, was dramatically enlarged, particularly both its dorsal portion and membrane, that is, the cloacal membrane resulting from the development of the tailgut derived from the tail bud...
March 2013: Congenital Anomalies
https://www.readbyqxmd.com/read/23155310/traditional-chinese-surgical-treatment-for-anal-fistulae-with-secondary-tracks-and-abscess
#20
RANDOMIZED CONTROLLED TRIAL
Chen Wang, Jin-Gen Lu, Yong-Qing Cao, Yi-Bo Yao, Xiu-Tian Guo, Hao-Qiang Yin
AIM: To evaluate the efficacy and safety of traditional Chinese surgical treatment for anal fistulae with secondary tracks and abscess. METHODS: Sixty patients with intersphincteric or transsphincteric anal fistulas with secondary tracks and abscess were randomly divided into study group [suture dragging combined with pad compression (SDPC)] and control group [fistulotomy (FSLT)]. In the SDPC group, the internal opening was excised and incisions at external openings were made for drainage...
October 28, 2012: World Journal of Gastroenterology: WJG
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