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One Health AND Antimicrobial resistance

Yujie Hu, Yingying He, Yao Bai, Fengqin Li, Jin Xu
OBJECTIVE: Research were carried out to determine the antimicrobial resistance and mechanism of Salmonella isolates recovered from retail chicken carcasses in Beijing in summer, 2013. METHODS: Broth microdilution method were used for antimicrobial susceptibility testing to obtain the minimal inhibitory concentration( MICs)against 11 antimicrobial compounds which belongs to 8 categories and 166 Salmonella strains isolated from 33 retail chicken carcasses in Beijing in summer, 2013 were tested...
July 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
Arockiasamy Arun Prince Milton, Rajesh Kumar Agarwal, Govindarajan Bhuvana Priya, Cheruplackal Karunakaran Athira, Mani Saminathan, Avinash Reddy, Manivasagam Aravind, Ashok Kumar
Occurrence of Salmonella spp. in captive wild animal species in India is largely unknown. The purpose of this study was to determine the occurrence of different Salmonella serotypes, antimicrobial resistance patterns and genotypic relatedness of recovered isolates. A total of 370 samples including faecal (n = 314), feed and water (n = 26) and caretakers stool swabs (n = 30) were collected from 40 different wild animal species in captivity, their caretakers, feed and water in four zoological gardens and wildlife enclosures in India...
June 14, 2018: Epidemiology and Infection
Rosario Oliva, Marco Chino, Katia Pane, Valeria Pistorio, Augusta De Santis, Elio Pizzo, Gerardino D'Errico, Vincenzo Pavone, Angela Lombardi, Pompea Del Vecchio, Eugenio Notomista, Flavia Nastri, Luigi Petraccone
Cationic antimicrobial peptides (CAMPs) are a promising alternative to treat multidrug-resistant bacteria, which have developed resistance to all the commonly used antimicrobial, and therefore represent a serious threat to human health. One of the major drawbacks of CAMPs is their sensitivity to proteases, which drastically limits their half-life. Here we describe the design and synthesis of three nine-residue CAMPs, which showed high stability in serum and broad spectrum antimicrobial activity. As for all peptides a very low selectivity between bacterial and eukaryotic cells was observed, we performed a detailed biophysical characterization of the interaction of one of these peptides with liposomes mimicking bacterial and eukaryotic membranes...
June 11, 2018: Scientific Reports
Amlan Kumar Patra, Salah Amasheh, Jörg Rudolf Aschenbach
The use of antibiotics in diets has been restricted in several countries as a precautionary measure to avoid development of antibiotic resistance among pathogenic microorganisms. This regulation promoted the exploration of natural plant bioactive compounds (PBCs) as feed additives to improve productivity, welfare and health of livestock and poultry. Along with several beneficial attributes of PBCs, including antimicrobial, antioxidant and various pharmacological effects, they also improve barrier function and nutrient transport in the gastrointestinal (GI) tract...
June 11, 2018: Critical Reviews in Food Science and Nutrition
Sara Lomonaco, Matthew A Crawford, Christine Lascols, Ruth E Timme, Kevin Anderson, David R Hodge, Debra J Fisher, Segaran P Pillai, Stephen A Morse, Erum Khan, Molly A Hughes, Marc W Allard, Shashi K Sharma
The emergence and dissemination of carbapenemases, bacterial enzymes able to inactivate most β-lactam antibiotics, in Enterobacteriaceae is of increasing concern. The concurrent spread of resistance against colistin, an antibiotic of last resort, further compounds this challenge further. Whole-genome sequencing (WGS) can play a significant role in the rapid and accurate detection/characterization of existing and emergent resistance determinants, an essential aspect of public health surveillance and response activities to combat the spread of antimicrobial resistant bacteria...
2018: PloS One
Zhen Zhu, Yuxiang Shi, Xuzheng Zhou, Bing Li, Jiyu Zhang
BACKGROUND: Members of the genus Shigella are intestinal pathogens and a major cause of seasonal outbreaks of bacterial diarrhea worldwide. Although humans are the conventional hosts of Shigella species, expansion of the Shigella host range to certain animals was recently reported. To investigate the prevalence of Shigella sonnei (S. sonnei) in yaks and perform molecular characterization, we analyzed 1132 fresh yak diarrheal stool samples and collected a total of 44 S. sonnei isolates...
June 7, 2018: BMC Veterinary Research
Helmut Bürgmann, Dominic Frigon, William Gaze, Célia Manaia, Amy Pruden, Andrew C Singer, Barth Smets, Tong Zhang
Water and sanitation represents a key battlefront in combating the spread of antimicrobial resistance (AMR). Basic water sanitation infrastructure is an essential first step to protecting public health, thereby limiting the spread of pathogens and the need for antibiotics. AMR presents unique human health risks, meriting new risk assessment frameworks specifically adapted to water and sanitation-borne AMR. There are numerous exposure routes to AMR originating from human waste, each of which must be quantified for its relative risk to human health...
June 5, 2018: FEMS Microbiology Ecology
Mary Ann Powles, Andrew Galgoci, Andrew Misura, Lawrence Colwell, Karen H Dingley, Wei Tang, Jin Wu, Timothy Blizzard, Mary Motyl, Katherine Young
The World Health Organization has identified antimicrobial resistance as a global public health threat as the prevalence and spread of antibiotic resistance among bacterial pathogens worldwide are staggering. Carbapenems, such as imipenem and meropenem have been used to treat multidrug-resistant bacteria; however, since the development of resistance to carbapenems, β-lactam antibiotics in combination with β-lactamase inhibitors (BLI) has been one of the most successful strategies to enhance the activity of β-lactam antibiotics...
June 4, 2018: Antimicrobial Agents and Chemotherapy
Jeffrey C Chandler, Sulaiman F Aljasir, Afrim Hamidi, Driton Sylejmani, Kenneth G Gerow, Bledar Bisha
The World Health Organization recently recognized the Republic of Kosovo as one of the highest consumers per capita of antibiotics for human use among non-European Union Eastern European countries; however, data are limited regarding antimicrobial usage and antimicrobial resistance in the livestock sector for this recently formed country. The objective of this study was to conduct the first nationwide survey of antimicrobial resistance phenotypes in indicator bacteria collected from dairy farms in Kosovo. Composite fecal samples were collected from 52 farms located within all 7 administrative districts of Kosovo in the summer of 2014...
May 30, 2018: Journal of Dairy Science
Passoret Vounba, Kane Yaghouba, Cheikh Ndiaye, Julie Arsenault, John Morris Fairbrother, Rianatou Bada Alambédji
Avian pathogenic Escherichia coli (APEC), a subset of extraintestinal pathogenic E. coli (ExPEC), are the etiologic agent of avian colibacillosis, one of the main causes of economic losses in the poultry industry. The aim of this study was to characterize E. coli isolated from diseased chickens in Senegal to elucidate their virulence potential and antimicrobial resistance (AMR). A total of 58 isolates, each from a separate farm, were characterized for AMR, virulence, and AMR genes, phylogroup, serogroup, biofilm formation, and pulsed-field gel electrophoresis, and for two isolates, whole-genome sequencing (WGS)...
May 31, 2018: Foodborne Pathogens and Disease
Naoufal Rahmatallah, Hicham El Rhaffouli, Idriss Lahlou Amine, Yassine Sekhsokh, Ouafaa Fassi Fihri, Mohammed El Houadfi
Monitoring the use of antibacterial agents in food-producing animals is crucial in order to reduce antimicrobial resistance, selection and dissemination of resistant bacterial strains, and drug residues in the animal food products. The broiler production sector is considered a great consumer of antibacterials and incriminated in the rise of antimicrobial resistance level in zoonotic bacterial pathogens such as Escherichia coli, Salmonella and Campylobacter. Following recommendations from the OIE and WHO, a survey was conducted about the use and consumption of several antibacterial agents in Moroccan broiler flocks...
May 2018: Veterinary Medicine and Science
Joanna L McParland, Lynn Williams, Lucyna Gozdzielewska, Mairi Young, Fraser Smith, Jennifer MacDonald, Darren Langdridge, Mark Davis, Lesley Price, Paul Flowers
OBJECTIVES: Changing public awareness of antimicrobial resistance (AMR) represents a global public health priority. A systematic review of interventions that targeted public AMR awareness and associated behaviour was previously conducted. Here, we focus on identifying the active content of these interventions and explore potential mechanisms of action. METHODS: The project took a novel approach to intervention mapping utilizing the following steps: (1) an exploration of explicit and tacit theory and theoretical constructs within the interventions using the Theoretical Domains Framework (TDFv2), (2) retrospective coding of behaviour change techniques (BCTs) using the BCT Taxonomy v1, and (3) an investigation of coherent links between the TDF domains and BCTs across the interventions...
May 27, 2018: British Journal of Health Psychology
Mohamed Zeineldin, Brian Aldridge, Benjamin Blair, Katherine Kancer, James Lowe
The continuous administration of antimicrobials in swine production has been widely criticized with the increase of antimicrobial-resistant bacteria and dysbiosis of the beneficial microbial communities. While an increasing number of studies investigate the effects of antimicrobial administration on swine gastrointestinal microbiota biodiversity, the impact of their use on the composition and diversity of nasal microbial communities has not been widely explored. The objective of this study was to characterize the short-term impact of different parenteral antibiotics administration on the composition and diversity of nasal microbial communities in growing pigs...
May 24, 2018: Microbial Pathogenesis
Francesco Menichetti, Marco Falcone, Pierluigi Lopalco, Carlo Tascini, Angelo Pan, Luca Busani, Bruno Viaggi, Gian Maria Rossolini, Fabio Arena, Andrea Novelli, Francesco De Rosa, Stefania Iannazzo, Jonathan Cohen
The spread of antibiotic resistance is one of the leading public health problems in Italy. An ECDC country-site visit recently confirmed the major challenges and made important suggestions. In response, the Ministry of Health published the National Plan for Antimicrobial Resistance Containment, and a group of experts belonging to the Italian Group of Antimicrobial Stewardship (GISA), convened to develop a summary of practical recommendations. The GISA document is intended for use by practising physicians; it aims to increase the rational use of antimicrobials and in the treatment of infections, and to change the culture of infection control of antibiotic-resistant bacteria, through the translation of theoretical knowledge into priority actions...
May 23, 2018: International Journal of Antimicrobial Agents
Solveig Sølverød Mo, Anne Margrete Urdahl, Knut Madslien, Marianne Sunde, Live L Nesse, Jannice Schau Slettemeås, Madelaine Norström
The objective of this study was to estimate and compare the occurrence of AMR in wild red foxes in relation to human population densities. Samples from wild red foxes (n = 528) included in the Norwegian monitoring programme on antimicrobial resistance in bacteria from food, feed and animals were included. All samples were divided into three different groups based on population density in the municipality where the foxes were hunted. Of the 528 samples included, 108 (20.5%), 328 (62.1%) and 92 (17.4%) originated from areas with low, medium and high population density, respectively...
2018: PloS One
Javiera Cornejo, Karina Yevenes, Constanza Avello, Ekaterina Pokrant, Aldo Maddaleno, Betty San Martin, Lisette Lapierre
Tetracyclines are important antimicrobial drugs for poultry farming that are actively excreted via feces and urine. Droppings are one of the main components in broiler bedding, which is commonly used as an organic fertilizer. Therefore, bedding becomes an unintended carrier of antimicrobial residues into the environment and may pose a highly significant threat to public health. For this depletion study, 60 broiler chickens were treated with 20% chlortetracycline (CTC) under therapeutic conditions. Concentrations of CTC and 4-epi-CTC were then determined in their droppings...
May 25, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Leslie A Rank, Naomi M Walsh, Fang Yun Lim, Samuel H Gellman, Nancy P Keller, Christina M Hull
Understanding the dimensions of fungal diversity has major implications for the control of diseases in humans, plants, and animals and in the overall health of ecosystems on the planet. One ancient evolutionary strategy organisms use to manage interactions with microbes, including fungi, is to produce host defense peptides (HDPs). HDPs and their synthetic analogs have been subjects of interest as potential therapeutic agents. Due to increases in fungal disease worldwide, there is great interest in developing novel antifungal agents...
May 2018: MSphere
Kathrin U Jansen, Annaliesa S Anderson
The problem of antimicrobial resistance (AMR) and the associated morbidity and mortality due to antibiotic resistant bacterial pathogens is not new. However, AMR has been increasing at an alarming rate with appearances of diseases caused by bacteria exhibiting resistance to not just one but multiple classes of antibiotics. The World Health Organization (WHO) supported by governments, health ministries and health agencies has formulated global action plans to combat the rise in AMR, supporting a number of proven initiatives such as antimicrobial stewardship, investments in development of new classes of antibiotics, and educational programs designed to eliminate inappropriate antibiotic use...
May 22, 2018: Human Vaccines & Immunotherapeutics
Salma M Al-Zain Ahmed, Sara S Abdelrahman, Doua M Saad, Isra S Osman, Modasir G Osman, Eltahir A G Khalil
Background: Respiratory infections are one of the commonest causes of morbidity and mortality related to infectious diseases worldwide. The emergence of antimicrobial resistance is a major global health problem which is well established in developing countries. Good clinical suspicion and correct laboratory identification of respiratory infection causing organisms followed by the appropriate management are needed to compact both community-acquired and nosocomial infection respiratory infections...
2018: Open Microbiology Journal
Sileshi Tadesse, Haile Alemayehu, Admasu Tenna, Getachew Tadesse, Tefaye Sisay Tessema, Workineh Shibeshi, Tadesse Eguale
BACKGROUND: Staphylococcus aureus is one of the major pathogens of public health importance responsible for various forms of infection. Development of resistance to commonly used antimicrobials limited treatment options against infections due to this pathogen. Antimicrobial resistance profile of Staphylococcus aureus isolated from patients with surgical site infection and ear infection and corresponding nasal swab was investigated in Tikur Anbessa Specialized Hospital (TASH), Addis Ababa, Ethiopia...
May 21, 2018: BMC Pharmacology & Toxicology
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