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One Health AND Antimicrobial resistance

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https://www.readbyqxmd.com/read/28410366/brief-educational-interventions-to-improve-performance-on-novel-quality-metrics-in-ambulatory-settings-in-kenya-a-multi-site-pre-post-effectiveness-trial
#1
Robert Ryan Korom, Stephanie Onguka, Peter Halestrap, Maureen McAlhaney, Mary Adam
BACKGROUND: The quality of primary care delivered in resource-limited settings is low. While some progress has been made using educational interventions, it is not yet clear how to sustainably improve care for common acute illnesses in the outpatient setting. Management of urinary tract infection is particularly important in resource-limited settings, where it is commonly diagnosed and associated with high levels of antimicrobial resistance. We describe an educational programme targeting non-physician health care providers and its effects on various clinical quality metrics for urinary tract infection...
2017: PloS One
https://www.readbyqxmd.com/read/28409380/bacterial-thiol-oxidoreductases-from-basic-research-to-new-antibacterial-strategies
#2
REVIEW
Katarzyna M Bocian-Ostrzycka, Magdalena J Grzeszczuk, Anna M Banaś, Elżbieta Katarzyna Jagusztyn-Krynicka
The recent, rapid increase in bacterial antimicrobial resistance has become a major public health concern. One approach to generate new classes of antibacterials is targeting virulence rather than the viability of bacteria. Proteins of the Dsb system, which play a key role in the virulence of many pathogenic microorganisms, represent potential new drug targets. The first part of the article presents current knowledge of how the Dsb system impacts function of various protein secretion systems that influence the virulence of many pathogenic bacteria...
April 13, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28400212/susceptibility-to-18-drugs-and-multidrug-resistance-of-arcobacter-isolates-from-different-sources-within-the-czech-republic
#3
David Šilha, Marcela Pejchalová, Lucie Šilhová
OBJECTIVES: Arcobacter spp. are considered to be potential foodborne pathogens, and consumption of contaminated food containing these bacteria could endanger human and animal health. Arcobacter butzleri and Arcobacter cryaerophilus are the species most frequently isolated from food of animal origin and from other samples. The aim of this study was to evaluate the susceptibility of arcobacters isolated in the Czech Republic. No information about antibiotic susceptibility and multidrug resistance of arcobacters isolated in the Czech Republic is available in the literature before now...
April 8, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28399941/antimicrobial-potential-of-bacteriocins-in-poultry-and-swine-production
#4
REVIEW
Amel Ben Lagha, Bruno Haas, Marcelo Gottschalk, Daniel Grenier
The routine use of antibiotics in agriculture has contributed to an increase in drug-resistant bacterial pathogens in animals that can potentially be transmitted to humans. In 2000, the World Health Organization identified resistance to antibiotics as one of the most significant global threats to public health and recommended that the use of antibiotics as additives in animal feed be phased out or terminated, particularly those used to treat human infections. Research is currently being carried out to identify alternative antimicrobial compounds for use in animal production...
April 11, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28392809/in-vitro-susceptibility-of-mycobacterium-ulcerans-isolates-to-selected-antimicrobials
#5
Enid Owusu, Mercy J Newman, Kwesi K Addo, Phyllis Addo
Background. The current definitive treatment of Buruli ulcer with antibiotics makes the issue of antimicrobial drug resistance an unavoidable one. This is as a result of drug misuse by health personnel and patients' noncompliance to treatment regimen. Monitoring of these factors and screening for new effective antimicrobials are crucial to effective management of Buruli ulcer disease. This study therefore investigated the inhibitory activity of some antibiotics against isolates of Mycobacterium ulcerans. Methods...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/28392536/potential-enterotoxicity-and-antimicrobial-resistance-pattern-of-aeromonas-species-isolated-from-pet-turtles-and-their-environment
#6
S H M P Wimalasena, Gee-Wook Shin, Sabrina Hossain, Gang-Joon Heo
To investigate the potential enterotoxicity and antimicrobial resistance of aeromonads from pet turtles as a risk for human infection, one hundred and two Aeromonas spp. were isolated from the feces, skin and rearing environments of pet turtles and identified by biochemical and gyrB sequence analyses. Aeromonas enteropelogenes was the predominant species among the isolates (52.9%) followed by A. hydrophila (32.4%), A. dharkensis (5.9%), A. veronii (4.9%) and A. caviae (3.9%). Their potential enterotoxicities were evaluated by PCR assays for detecting genes encoding cytotoxic enterotoxin (act) and two cytotonic enterotoxins (alt and ast)...
April 10, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28389548/effect-of-tetracycline-dose-and-treatment-mode-on-selection-of-resistant-coliform-bacteria-in-nursery-pigs
#7
Kaare Græsbøll, Peter Damborg, Anders Mellerup, Ana Herrero-Fresno, Inge Larsen, Anders Holm, Jens Peter Nielsen, Lasse Engbo Christiansen, Øystein Angen, Shahana Ahmed, Anders Folkesson, John Elmerdahl Olsen
This study describes results of a randomized clinical trial investigating the effect of oxytetracycline treatment dose and mode of administration on selection of antibiotic resistant coliform bacteria in fecal samples from nursery pigs. Nursery pigs (pigs of 4-7 weeks of age) were treated with oxytetracycline against Lawsonia intracellularis induced diarrhea in five pig herds. Each group was randomly allocated to one of five treatment groups: oral flock treatment with (i) high (20 mg/kg), (ii) medium (10 mg/kg) and (iii) low (5 mg/kg) dosage, (iv) oral-pen-wise (small group) treatment (10 mg/kg), and (v) individual intramuscular injection treatment (10mg/kg)...
April 7, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28385463/clinical-and-social-barriers-to-antimicrobial-stewardship-in-pulmonary-medicine-a-qualitative-study
#8
Jennifer K Broom, Alex F Broom, Emma R Kirby, Alexandra F Gibson, Jeffrey J Post
BACKGROUND: The treatment of pulmonary infections is one of the largest indications for antibiotics in human health care, offering significant potential for antibiotic optimization internationally. This study explores the perspectives of pulmonary clinicians on antibiotic use in hospital pulmonary infections. METHODS: Twenty-eight pulmonary doctors and nurses from 2 hospitals participated in semi-structured interviews focusing on their experiences of antibiotic use...
April 3, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28384139/antifungal-drug-testing-by-combining-minimal-inhibitory-concentration-testing-with-target-identification-by-gas-chromatography-mass-spectrometry
#9
Christoph Müller, Ulrike Binder, Franz Bracher, Martin Giera
Fungal infections and their increasing resistance to antibiotics are an emerging threat to public health. Novel antifungal drugs, as well technologies that can help us bolster the antimicrobial pipeline and understand resistance mechanisms, are needed. The ergosterol biosynthetic pathway is one potential target for antifungal drugs. Here we describe how antifungal susceptibility testing can be combined with target identification in distal ergosterol biosynthesis by means of gas chromatography-mass spectrometry...
May 2017: Nature Protocols
https://www.readbyqxmd.com/read/28376713/prevalence-and-antimicrobial-resistance-of-campylobacter-jejuni-and-campylobacter-coli-isolated-from-children-and-environmental-sources-in-urban-and-suburban-areas
#10
Bernadeta Szczepanska, Małgorzata Andrzejewska, Dorota Spica, Jacek J Klawe
BACKGROUND: Campylobacteriosis is a dominant bacterial cause of foodborne infection and is considered the main public health problem in Europe and many other countries worldwide. In the study lasting from 2011 to 2013 we compared the prevalence and antimicrobial resistance of Campylobacter jejuni and Campylobacter coli isolated from children, domestic animals, poultry meat and surface water in Northern Poland. RESULTS: During a 3-years study 1973 samples were analysed...
April 4, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28367887/antimicrobial-resistance-of-pseudomonas-aeruginosa-isolated-from-dogs-and-cats-in-primary-veterinary-hospitals-in-japan
#11
Shoichiro Yukawa, Yuzo Tsuyuki, Tomomi Sato, Akira Fukuda, Masaru Usui, Yutaka Tamura
To investigate antimicrobial resistance, 200 Pseudomonas aeruginosa isolates were collected from dogs and cats in primary veterinary hospitals in Japan. Resistance rates against ciprofloxacin, cefotaxime, gentamicin, amikacin, and fosfomycin were 9, 12.5, 4.5, 2.5, and 35.5%, respectively. One strain (0.5%) displayed resistance to ceftazidime. We did not detect any strain resistant to imipenem nor any multidrug-resistant P. aeruginosa as defined by the Law Concerning the Prevention of Infections and Medical Care for Patients with Infections of the Japanese Ministry of Health, Labour, and Welfare...
March 28, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28365922/molecular-characterization-and-antimicrobial-susceptibility-of-pasteurella-multocida-strains-isolated-from-hosts-affected-by-various-diseases-in-italy
#12
Lucilla Cucco, Francesca Romana Massacci, Carla Sebastiani, Piermario Mangili, Luca Bano, Monia Cocchi, Andrea Luppi, Roberta Ortenzi, Giovanni Pezzotti, Chiara Francesca Magistrali
Pasteurella multocida is a widespread pathogen associated with major animal diseases of economic significance. Despite this, little is known about the capsular types, virulence gene pattern, and antimicrobial susceptibility of isolates from hosts affected by different diseases, and no data are available in Italy. One hundred eighty six isolates of P. multocida, were taken from different species in different states of health in several Italian regions, and were tested for genes encoding for capsular types (cap) and major virulence factors (tbpA, toxA, hgbB and pfhA)...
March 31, 2017: Veterinaria Italiana
https://www.readbyqxmd.com/read/28362299/towards-a-research-agenda-for-water-sanitation-and-antimicrobial-resistance
#13
Susanne Wuijts, Harold H J L van den Berg, Jennifer Miller, Lydia Abebe, Mark Sobsey, Antoine Andremont, Kate O Medlicott, Mark W J van Passel, Ana Maria de Roda Husman
Clinically relevant antimicrobial resistant bacteria, genetic resistance elements, and antibiotic residues (so-called AMR) from human and animal waste are abundantly present in environmental samples. This presence could lead to human exposure to AMR. In 2015, the World Health Organization (WHO) developed a Global Action Plan for Antimicrobial Resistance with one of its strategic objectives being to strengthen knowledge through surveillance and research. With respect to a strategic research agenda on water, sanitation and hygiene and AMR, WHO organized a workshop to solicit input by scientists and other stakeholders...
April 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/28358258/prevalence-and-antimicrobial-resistance-of-salmonella-in-market-raw-oysters-in-taiwan
#14
Yung-Tsun Lo, Chia-Lan Wang, Bai-Hsung Chen, Chung-Wen Hu, Chung-Hsi Chou
We tested 137 samples of domestic shucked oysters and 114 samples of imported oysters collected from traditional retail markets and supermarkets during 2010 and 2011 in Taiwan for the presence of Salmonella . We obtained a total of 91 Salmonella isolates, representing nine serotypes, from 80 of the domestic samples. We did not find any Salmonella in the imported oysters. The presence of Salmonella contamination tended to be specific to the area from which the oysters were harvested: the Dongshih area had a significantly higher contamination rate (68...
March 30, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28350449/long-chained-4-aminoquinolines-as-quorum-sensing-inhibitors-in-serratia-marcescens-and-pseudomonas-aeruginosa
#15
Ivana Aleksić, Sandra Šegan, Filip Andric, Mario Zlatović, Ivana Moric, Dejan M Opsenica, Lidija Senerovic
Antibiotic resistance has become serious global threat to public health; therefore, the improved strategies and structurally novel antimicrobials are urgently needed to combat infectious diseases. Here we report a new type of highly potent 4-aminoquinoline derivatives as quorum sensing inhibitors in Serratia marcescens and Pseudomonas aeruginosa, exhibiting weak bactericidal activities (MIC > 400 μM). Through detailed structure-activity study we have identified 7-Cl and 7-CF3 substituted N-dodecylamino-4-aminoquinolines (5 and 10) as biofilm formation inhibitors with 50% biofilm inhibition at 69 μM and 63 μM in S...
March 28, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28347610/abundance-of-antibiotics-antibiotic-resistance-genes-and-bacterial-community-composition-in-wastewater-effluents-from-different-romanian-hospitals
#16
Edina Szekeres, Andreea Baricz, Cecilia Maria Chiriac, Anca Farkas, Ocsana Opris, Maria-Loredana Soran, Adrian-Stefan Andrei, Knut Rudi, Jose Luis Balcázar, Nicolae Dragos, Cristian Coman
Antimicrobial resistance represents a growing and significant public health threat, which requires a global response to develop effective strategies and mitigate the emergence and spread of this phenomenon in clinical and environmental settings. We investigated, therefore, the occurrence and abundance of several antibiotics and antibiotic resistance genes (ARGs), as well as bacterial community composition in wastewater effluents from different hospitals located in the Cluj County, Romania. Antibiotic concentrations ranged between 3...
March 24, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28346030/antimicrobial-activity-of-eugenol-and-essential-oils-containing-eugenol-a-mechanistic-viewpoint
#17
Anna Marchese, Ramona Barbieri, Erika Coppo, Ilkay Erdogan Orhan, Maria Daglia, Seyed Fazel Nabavi, Morteza Izadi, Mohammad Abdollahi, Seyed Mohammad Nabavi, Marjan Ajami
Eugenol is a hydroxyphenyl propene, naturally occurring in the essential oils of several plants belonging to the Lamiaceae, Lauraceae, Myrtaceae, and Myristicaceae families. It is one of the major constituents of clove (Syzygium aromaticum (L.) Merr. & L.M. Perry, Myrtaceae) oil and is largely used in both foods and cosmetics as a flavoring agent. A large body of recent scientific evidence supports claims from traditional medicine that eugenol exerts beneficial effects on human health. These effects are mainly associated with antioxidant and anti-inflammatory activities...
March 27, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28339695/incidence-and-outcomes-of-infections-caused-by-multidrug-resistant-enterobacteriaceae-in-children-2007-2015
#18
Sharon B Meropol, Allison A Haupt, Sara M Debanne
Background.: The escalating incidence of invasive disease caused by multidrug-resistant Gram-negative enteric Enterobacteriaceae (MDR-GNE) is a global concern. Scant published studies in which the epidemiology of these infections in children is described exist; previous studies focused mainly on adults, described circumscribed populations, or lacked clinical detail. The objective of this study was to examine and describe the incidence, risk factors, and outcomes associated with MDR-GNE infection in children...
February 22, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28336882/antimicrobial-polymers-in-the-nano-world
#19
REVIEW
Marta Álvarez-Paino, Alexandra Muñoz-Bonilla, Marta Fernández-García
Infections are one of the main concerns of our era due to antibiotic-resistant infections and the increasing costs in the health-care sector. Within this context, antimicrobial polymers present a great alternative to combat these problems since their mechanisms of action differ from those of antibiotics. Therefore, the microorganisms' resistance to these polymeric materials is avoided. Antimicrobial polymers are not only applied in the health-care sector, they are also used in many other areas. This review presents different strategies that combine nanoscience and nanotechnology in the polymer world to combat contaminations from bacteria, fungi or algae...
February 22, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28333200/antibiotic-prescribing-frequency-amongst-patients-in-primary-care-a-cohort-study-using-electronic-health-records
#20
Laura Shallcross, Nick Beckley, Greta Rait, Andrew Hayward, Irene Petersen
Background: Reducing inappropriate antibiotic prescribing in primary care is a public health priority. Objectives: We hypothesized that a subset of patients account for the majority of antibiotic prescriptions in primary care. We investigated the relationship between the total amount of antibiotics prescribed, individual-level antibiotic use and comorbidity. Methods: This was a cohort study using electronic health records from 1 948 390 adults registered with 385 primary care practices in the UK in 2011-13...
February 21, 2017: Journal of Antimicrobial Chemotherapy
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