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post operative cognitive dysfunction (POCD)

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https://www.readbyqxmd.com/read/28479899/effects-of-vasodilator-and-esmolol-induced-hemodynamic-stability-on-early-post-operative-cognitive-dysfunction-in-elderly-patients-a-randomized-trial
#1
Sheng-Hui Sun, Lin Yang, De-Feng Sun, Yue Wu, Jun Han, Ruo-Chuan Liu, Li-Jie Wang
OBJECTIVE: To investigate the effect of continuous intravenous injection of nicardipine and/or nitroglycerin with or without esmolol on the occurrence of early post-operative cognitive dysfunction (POCD) in elderly patients. METHODS: Elderly patients (n=340) who underwent radiofrequency ablation for atrial fibrillation were randomized into five groups: A, nicardipine; B nicardipine+esmolol; C, (nitroglycerin) group; D nitroglycerin+esmolol; E (control) groups. The hemodynamic parameters were recorded, and Mini Mental State Examination was used to assess cognitive function...
December 2016: African Health Sciences
https://www.readbyqxmd.com/read/28465805/pathogenesis-and-treatment-of-post-operative-cognitive-dysfunction
#2
REVIEW
Maria Pappa, Nikolaos Theodosiadis, Andreas Tsounis, Pavlos Sarafis
Cognitive disorders common in the post-operative period, are the post-operative delirium (POD) and the post-operative cognitive dysfunction (POCD). The Diagnostic and Statistical Manual of Mental Disorders (DSM) does not mention POCD as a separate disease entity, and thus little is known about the pathogenesis of this disorder. The aim of this study was to review, detect and highlight the most important data cited, regarding pathogenesis mechanisms and treatment of the post-operative cognitive dysfunction (POCD)...
February 2017: Electronic Physician
https://www.readbyqxmd.com/read/28411068/protective-effect-of-dapsone-on-cognitive-impairment-induced-by-propofol-involves-hippocampal-autophagy
#3
Ning Yang, Lunxu Li, Zhengqian Li, Cheng Ni, Yiyun Cao, Taotao Liu, Miao Tian, Dehua Chui, Xiangyang Guo
Post-operative cognitive dysfunction (POCD) is a commonly seen postoperative complication in elderly patients and its underlying mechanisms are still unclear. Autophagy, a degradation mechanism of cellular components, is required for cell survival and many physiological processes. Although propofol is one of the most commonly used intravenous anesthetics, investigations into its mechanisms and effects on cognition in aged rodents are relatively scarce. In this study, we evaluate the influence of propofol on learning and memory, and identify the potential role of hippocampal autophagy in propofol-induced cognitive alterations in aged rats...
April 12, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28317003/peri-operative-inflammatory-cytokines-in-plasma-of-the-elderly-correlate-in-prospective-study-with-postoperative-changes-in-cognitive-test-scores
#4
R Kline, E Wong, M Haile, S Didehvar, S Farber, A Sacks, E Pirraglia, M J de Leon, A Bekker
Increasingly, postoperative cognitive dysfunction (POCD) is recognized as a complication after surgery in the elderly; but it's etiology remains unclear. Here we examine changes in cytokine levels during both the pre-operative and postoperative period, comparing them with long term variation in cognitive test scores. Forty-one patients aged 65 and older undergoing major surgery with general anesthesia were recruited after written consent in this IRB approved study. Thirty went on to complete this prospective, non-interven-tional and non-randomized study...
August 2016: International Journal of Anesthesiology & Research
https://www.readbyqxmd.com/read/28302254/cognitive-reserve-and-the-risk-of-postoperative-cognitive-dysfunction
#5
Insa Feinkohl, Georg Winterer, Claudia D Spies, Tobias Pischon
BACKGROUND: Post-operative cognitive dysfunction (POCD) occurs in 10 to 54% of older patients during the first few weeks after surgery, but little is known about risk factors predisposing to POCD. METHODS: Systematic literature review and meta-analysis of cognitive reserve indicators and POCD risk. RESULTS: Fifteen studies on 5104 patients were included. Follow-up periods spanned 1 day to 6 months. Educational level was the most commonly assessed cognitive reserve indicator, and a longer time spent in education was associated with a reduced risk of POCD (relative risk [RR] per year increment 0...
February 17, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28224377/curcumin-attenuates-surgery-induced-cognitive-dysfunction-in-aged-mice
#6
Xiang Wu, Huixin Chen, Chunhui Huang, Xinmei Gu, Jialing Wang, Dilin Xu, Xin Yu, Chu Shuai, Liping Chen, Shun Li, Yiguo Xu, Tao Gao, Mingrui Ye, Wei Su, Haixiong Liu, Jinrong Zhang, Chuang Wang, Junping Chen, Qinwen Wang, Wei Cui
Post-operative cognitive dysfunction (POCD) is associated with elderly patients undergoing surgery. However, pharmacological treatments for POCD are limited. In this study, we found that curcumin, an active compound derived from Curcuma longa, ameliorated the cognitive dysfunction following abdominal surgery in aged mice. Further, curcumin prevented surgery-induced anti-oxidant enzyme activity. Curcumin also increased brain-derived neurotrophic factor (BDNF)-positive area and expression of pAkt in the brain, suggesting that curcumin activated BDNF signaling in aged mice...
June 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28217289/peripheral-surgical-wounding-may-induce-cognitive-impairment-through-interlukin-6-dependent-mechanisms-in-aged-mice
#7
Yuanlin Dong, Zhipeng Xu, Lining Huang, Yiying Zhang, Zhongcong Xie
Post-operative cognitive dysfunction (POCD) is associated with morbidity, mortality and increased cost of medical care. However, the neuropathogenesis and targeted interventions of POCD remain largely to be determined. We have found that the peripheral surgical wounding induces an age-dependent Aβ accumulation, neuroinflammation and cognitive impairment in aged mice. Pro-inflammatory cytokine interlukin-6 (IL-6) has been reported to be associated with cognitive impairment in rodents and humans. However, the role of IL-6 in the neuropathogenesis of POCD is unknown...
October 2016: Medical Gas Research
https://www.readbyqxmd.com/read/28063267/diabetes-and-hyperglycemia-are-associated-with-risk-of-postoperative-cognitive-dysfunction-a-meta-analysis
#8
I Feinkohl, G Winterer, T Pischon
BACKGROUND: Postoperative cognitive dysfunction (POCD) occurs frequently after surgery, particularly among older people. Diabetes, chronic hyperglycemia, and a history of hypoglycemia are related to cognitive impairment, but little is known about their roles in POCD. Here, we estimated their associations with risk of POCD on the basis of published epidemiological research. METHODS: The PubMed and Cochrane databases were searched for longitudinal studies of adults undergoing surgery with reporting of associations of diabetes status, glycemic levels, and/or a history of hypoglycemia with risk of POCD as relative risks or odds ratios...
January 7, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28048971/insulin-resistance-plays-a-potential-role-in-postoperative-cognitive-dysfunction-in-patients-following-cardiac-valve-surgery
#9
Ni Tang, Rongrong Jiang, Xiaobin Wang, Jian Wen, Li Liu, Jiali Wu, Chunxiang Zhang
Severe insulin resistance(IR) promotes the development of Alzheimer disease. IR and postoperative cognitive dysfunction (POCD) are a common complication during the cardiac perioperative period. The authors hypothesized that IR of individuals with cardiac valve surgery would have increased the risk of POCD. The purpose of the study was to analyze the association of IR and POCD after cardiac valve surgery. Total 131 patients who underwent valve replacement via cardiopulmonary bypass(CPB) were included. Cognitive function was assessed by a series of neuropsychological measurements at 1 day before and 7 days after the surgery...
December 31, 2016: Brain Research
https://www.readbyqxmd.com/read/27600013/-incidence-of-the-post-operative-cognitive-dysfunction-in-elderly-patients-with-general-anesthesia-combined-with-epidural-anesthesia-and-patient-controlled-epidural-analgesia
#10
RANDOMIZED CONTROLLED TRIAL
Yan Wang, Xiaohua Liu, Haiying Li
OBJECTIVE: To explore the effect of general anesthesia combined with epidural anesthesia and patient-controlled epidural analgesia on the incidence of the post-operative cognitive dysfunction (POCD) in elderly patients.
 METHODS: A total of 100 elderly patients with gastric cancer, who underwent radical gastrectomy in Yan'an People's Hospital from March 2012 to March 2015, were randomly divided into 3 groups: a general anesthesia and patient-controlled intravenous analgesia (PCIA) (Group I, n=35), a general anesthesia combined with epidural anesthesia and PCIA (Group II, n=30), and a general anesthesia combined with epidural anesthesia and patient-controlled epidural analgesia (PCEA) (Group III, n=35)...
August 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27578364/no-convincing-association-between-post-operative-delirium-and-post-operative-cognitive-dysfunction-a-secondary-analysis
#11
RANDOMIZED CONTROLLED TRIAL
M Franck, K Nerlich, B Neuner, P Schlattmann, W R Brockhaus, C D Spies, F M Radtke
BACKGROUND: Post-operative delirium and post-operative cognitive dysfunction (POCD) are both common but it has not been clarified how closely they are associated. We aimed to assess the possible relationship in a secondary analysis of data from the 'Surgery Depth of anaesthesia and Cognitive outcome'- study. METHODS: We included patients aged ≥ 60 years undergoing non-cardiac surgery planned for longer than 60 min. Delirium was assessed according to the Diagnostic and Statistical Manual of Mental Disorders IV criteria in the post-anaesthesia care unit (PACU) as well as within the first week after surgery...
November 2016: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/27530591/risk-factors-for-the-development-of-post-operative-cognitive-dysfunction
#12
Maria D Pappa, Nikolaos V Theodosiadis, Andreas Tsounis, Pavlos Sarafis
BACKGROUND: Many studies have shown that a large number of patients undergoing surgery show a measurable cognitive deterioration after surgery, while many of them still show cognitive deficits even three months later an operation. These specific cognitive deficits in which there is a temporal association between surgery and mental disorders are defined as postoperative impairment of cognitive function. Among cognitive disorders occurring during the postoperative period, the post-operative cognitive dysfunction (POCD) is less studied...
2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27320248/association-of-ct-perfusion-and-postoperative-cognitive-dysfunction-after-off-pump-coronary-artery-bypass-grafting
#13
Zhe Song, Paul Fu, Mingying Chen, Qi Bi
OBJECTIVE: To investigate the relationship between an abnormal CT perfusion scan and postoperative cognitive dysfunction, as measured by changes in MoCA and MMSE scores, after off-pump coronary artery bypass grafting (OPCABG). METHODS: Eight hundred and thirteen patients were selected who underwent OPCABG between August 2010 and September 2013. Cognitive function was assessed before operation and at seven days post-op. CT perfusion scan was obtained preoperatively and was used to divide patients into two groups: abnormal perfusion and normal perfusion groups...
June 2016: Neurological Research
https://www.readbyqxmd.com/read/27222065/electroacupuncture-ameliorates-propofol-induced-cognitive-impairment-via-an-opioid-receptor-independent-mechanism
#14
Yan Liu, Xin-Juan Wang, Na Wang, Cai-Lian Cui, Liu-Zhen Wu
While general anesthesia is known to induce cognitive deficits in elderly and pediatric patients, its influence on adults is less well-characterized. The present study was designed to evaluate the influence of propofol on the learning and memory of young adult rats, as well as the potential neuroprotective role of electroacupuncture (EA) in propofol-induced cognitive impairment. Intravenous anesthesia with propofol was administered to young adult male Sprague-Dawley (SD) rats for 6 h, and EA was administered three times before and after anesthesia...
2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/26890984/obesity-and-post-operative-cognitive-dysfunction-a-systematic-review-and-meta-analysis
#15
Insa Feinkohl, Georg Winterer, Tobias Pischon
BACKGROUND: Post-operative cognitive dysfunction, a condition distinct from post-operative delirium (POD), occurs frequently after surgery, and is related to dementia and premature death. Obesity increases the risk of late-life cognitive impairment, but little is known about its role in post-operative cognitive dysfunction. We conducted a systematic review and meta-analysis of studies on the association between obesity and risk of post-operative cognitive dysfunction. METHODS: PubMed and the Cochrane Library were systematically searched...
September 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/26683785/orthopedic-surgery-and-post-operative-cognitive-decline-in-idiopathic-parkinson-s-disease-considerations-from-a-pilot-study
#16
Catherine C Price, Shellie-Anne Levy, Jared Tanner, Cyndi Garvan, Jade Ward, Farheen Akbar, Dawn Bowers, Mark Rice, Michael Okun
BACKGROUND: Post-operative cognitive dysfunction (POCD) demarks cognitive decline after major surgery but has been studied to date in "healthy" adults. Although individuals with neurodegenerative disorders such as Parkinson's disease (PD) commonly undergo elective surgery, these individuals have yet to be prospectively followed despite hypotheses of increased POCD risk. OBJECTIVE: To conduct a pilot study examining cognitive change pre-post elective orthopedic surgery for PD relative to surgery and non-surgery peers...
2015: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/26390674/perspective-on-cerebral-microemboli-in-cardiac-surgery-significant-problem-or-much-ado-about-nothing
#17
EDITORIAL
Simon J Mitchell, Alan F Merry
From the time an association was perceived between cardiac surgery and post-operative cognitive dysfunction (POCD), there has been interest in arterial microemboli as one explanation. A succession of studies in the mid-1990s reported a correlation between microemboli exposure and POCD and there followed a focus on microemboli reduction (along with other strategies) in pursuit of peri-operative neuroprotection. There is some evidence that the initiatives developed during this period were successful in reducing neurologic morbidity in cardiac surgery...
March 2015: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/26064392/the-effects-of-dexmedetomidine-on-post-operative-cognitive-dysfunction-and-inflammatory-factors-in-senile-patients
#18
Wenjin Chen, Bo Liu, Feng Zhang, Peng Xue, Rongsheng Cui, Weifu Lei
OBJECTIVE: To evaluate the effect of dexmedetomidine on post-operative cognitive dysfunction (POCD) and possible action mechanisms. METHODS: A total of 148 aged surgical patients were divided into two groups, which were treated with dexmedetomidine (Dex group) or normal saline (control group) during general anesthesia. The incidence of POCD one day after surgery was evaluated using Mini-Mental State Examination and serum levels of interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) were measured using ELISA...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/25988029/post-operative-cognitive-dysfunction-after-knee-arthroplasty-a-diagnostic-dilemma
#19
Kiryu K Yap, Peter Joyner
Post-operative cognitive dysfunction (POCD) is common in the elderly, and significantly impacts their recovery. We present an unusual diagnostic challenge where a 65-year-old male presented 4-week post-total knee arthroplasty with acute cognitive dysfunction lasting 19 days. Curiously, there were no findings uncovering a specific cause, but during investigation underlying predisposing factors such as depression, mild memory deficits and generalized brain volume loss were identified. The impression after psychogeriatric review was that of an organic brain syndrome with overlay of depression, with a complex presentation as POCD...
June 2014: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/25731052/-development-of-postoperative-cognitive-dysfunction-following-major-vascular-surgery
#20
Kazuyoshi Ishida, Atsuo Yamashita, Masato Uchida, Mishiya Matsumoto
The development of postoperative cognitive dysfunction (POCD) is a devastating complication, leading to a poor postoperative quality of life. Even though the number of patients undergoing major vascular surgery has increased, the development of POCD has not been well evaluated in these patients compared with patients undergoing coronary artery bypass graft surgery (CABG). According to previous reports, more patients undergoing major vascular surgery by deep circulatory arrest or retrograde cerebral perfusion, and an equal or even larger number of patients undergoing surgery by selective cerebral perfusion, seem to develop POCD when compared with patients after CABG...
November 2014: Masui. the Japanese Journal of Anesthesiology
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