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Gastrointestinal Malignancies

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https://www.readbyqxmd.com/read/29665727/changes-in-central-line-associated-bloodstream-infection-rates-among-children-with-immune-compromised-conditions-an-11-year-review
#1
Lauri A Linder, Cheryl Gerdy, Yeonjung Jo, Andrew Wilson
This article describes changes in central line-associated bloodstream infection (CLABSI) rates among common causative organisms over an 11-year period on a pediatric inpatient unit prior to and following CLABSI reduction strategies. The setting for this descriptive cohort design study was a 32-bed inpatient unit in a tertiary pediatric hospital serving children with immune compromised conditions, including cancer and recipients of hematopoietic stem cell and solid organ transplants. Between January 2006 and December 2016, 265 CLABSIs involving 189 patients were reported...
April 1, 2018: Journal of Pediatric Oncology Nursing: Official Journal of the Association of Pediatric Oncology Nurses
https://www.readbyqxmd.com/read/29665624/risk-of-gastrointestinal-bleeding-and-benefit-from-colorectal-cancer-reduction-from-long-term-use-of-low-dose-aspirin-a-retrospective-study-of-612-509-patients
#2
Kelvin K F Tsoi, Felix C H Chan, Hoyee W Hirai, Joseph J Y Sung
BACKGROUND: Aspirin, commonly used for prevention of cardiovascular and cerebrovascular diseases, is well-known to protect against development of colorectal cancer (CRC) but increases risk of gastrointestinal bleeding (GIB). AIM: This cohort study aims to evaluate the benefit of low-dose aspirin to prevent CRC and its associated risk of GIB. METHOD: A population-based dataset was used to compare incidence and mortality of CRC and GIB among patients receiving low-dose aspirin with sex-and-age matched controls (1:2)...
April 17, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29663543/surface-nanopore-engineering-of-2d-mxenes-for-targeted-and-synergistic-multitherapies-of-hepatocellular-carcinoma
#3
Zhenli Li, Han Zhang, Jun Han, Yu Chen, Han Lin, Tian Yang
Hepatocellular carcinoma (HCC) is one of the most common and deadly gastrointestinal malignancies. Given its insensitivity to traditional systematic chemotherapy, new therapeutic strategies for efficient HCCs treatment are urgently needed. Here, the development of a novel 2D MXene-based composite nanoplatform for highly efficient and synergistic chemotherapy and photothermal hyperthermia against HCC is reported. A surface-nanopore engineering strategy is developed for the MXenes' surface functionalization, which achieves the uniform coating of a thin mesoporous-silica layer onto the surface of 2D Ti3 C2 MXene (Ti3 C2 @mMSNs)...
April 16, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29662814/successful-surgical-treatment-of-a-recurrent-esophageal-malignant-gastrointestinal-neuroectodermal-tumor
#4
Seung Hwan Song, Jung Hoon Shin, Hyang Joo Ryu, Dae Joon Kim, Seong Yong Park
Malignant gastrointestinal neuroectodermal tumor (GNET) is a very rare disease entity, especially in the esophagus. The diagnosis of GNET is based on histologic, immunohistochemical, and genetic findings. The choice of treatment is complete resection, and further treatment options can be considered. Herein, we describe a case of successful surgical treatment of a 23-year-old man with recurrent malignant esophageal GNET.
April 2018: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29661713/review-with-novel-markers-facilitates-precise-categorization-of-41-cases-of-diagnostically-challenging-undifferentiated-small-round-cell-tumors-a-clinicopathologic-immunophenotypic-and-molecular-analysis
#5
Isidro Machado, Akihiko Yoshida, María Gema Nieto Morales, Lucas Faria Abrahão-Machado, Samuel Navarro, Julia Cruz, Javier Lavernia, Antonina Parafioriti, Piero Picci, Antonio Llombart-Bosch
BACKGROUND: Despite extensive immunohistochemical (IHC) and molecular studies combined with morphologic findings, a group of round/ovoid cell tumors histologically similar to Ewing sarcomas (ES) but lacking EWSR1-rearrangements may remain unclassifiable. DESIGN: We retrospectively analyzed 41 Ewing-like tumors (formalin-fixed, paraffin-embedded) previously determined as negative or non-informative for EWSR1-rearrangements by FISH and/or RT-PCR. A new histopathology revision and additional IHC and molecular analyses were carried out in order to investigate whether additional IHC and/or molecular testing in combination with the morphological findings may help in reaching a definitive diagnosis...
November 29, 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29661445/epidemiologic-profile-of-patients-transplanted-with-hematopoietic-stem-cells-in-a-reference-service-in-the-state-of-rio-grande-do-norte-brazil
#6
I Campos de Azevedo, M A Ferreira Júnior, L A Pereira de Aquino, A A de Oliveira, G K P Cruz, A I de Queiroz Cardoso, M L Ivo, V E P Santos
BACKGROUND: Hematopoietic stem cell transplantation (HSCT) consists of the intravenous infusion of healthy hematopoietic stem cells to restore the medullary and immunologic function of patients affected by a series of hematologic, oncologic, immunologic, malignant and nonmalignant inherited or acquired diseases, with the possibility of cure or increase of disease-free survival. OBJECTIVE: To characterize the epidemiologic profile and the cases of death of patients who underwent HSCT...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29661274/granular-cell-tumor-experience-at-a-comprehensive-cancer-center
#7
Ambria S Moten, Sujana Movva, Margaret von Mehren, Hong Wu, Nestor F Esnaola, Sanjay S Reddy, Jeffrey M Farma
BACKGROUND: Granular cell tumors (GCTs) are rare lesions occurring almost anywhere in the body. Multiple case reports have been published. However, there are very few large-scale studies regarding GCT. The aim of this study was to define characteristics, treatment patterns and outcomes of patients with GCT. METHODS: An institutional review board-approved retrospective chart review was performed. Descriptive statistics, chi-square analyses, and Kaplan-Meier survival estimates were produced...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29660811/natural-borneol-enhances-paclitaxel-induced-apoptosis-of-escc-cells-by-inactivation-of-the-pi3k-akt
#8
Xiaofeng Meng, Xiaomei Dong, Wen Wang, Liu Yang, Xia Zhang, Yanfang Li, Tianfeng Chen, Hang Ma, Da Qi, Jianyu Su
Paclitaxel (PTX) has been used in a variety of malignancies for inhibiting tumor development and improving survival. However, its clinical application is limited due to poor solubility, drug resistance, and gastrointestinal reactions. Natural borneol (NB), as a promoter, could help to improve drug absorption. Therefore, the aims of the present study were to investigate the ability of NB to synergize with PTX to induce human esophageal squamous cell carcinoma (ESCC) cells apoptosis and the underlying mechanism of synergistic effects...
April 16, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29659400/peliosis-hepatis-simulating-metastatic-liver-disease-on-fdg-pet-ct
#9
Daniel Levin, Nir Hod, Reut Anconina, Dina Ezroh Kazap, Ruthy Shaco-Levy, Sophie Lantsberg
A 20-year-old man with gastrointestinal symptoms and weight loss underwent FDG PET/CT, which revealed multiple hypermetabolic hepatic lesions concerning for metastatic liver disease. The outcome of liver biopsy was consistent with the diagnosis of peliosis hepatis which is a rare benign disease characterized by multiple blood-filled cystic spaces in the hepatic parenchyma. The findings of peliosis on FDG PET/CT are not well reported in the literature. These interesting images emphasize the importance of including peliosis hepatis in the differential diagnosis of multiple hypermetabolic hepatic lesions on FDG PET/CT, which could simulate malignancy...
April 13, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29657127/the-intestinal-microbiota-in-colorectal-cancer
#10
REVIEW
Herbert Tilg, Timon E Adolph, Romana R Gerner, Alexander R Moschen
Experimental evidence from the past years highlights a key role for the intestinal microbiota in inflammatory and malignant gastrointestinal diseases. Diet exhibits a strong impact on microbial composition and provides risk for developing colorectal carcinoma (CRC). Large metagenomic studies in human CRC associated microbiome signatures with the colorectal adenoma-carcinoma sequence, suggesting a fundamental role of the intestinal microbiota in the evolution of gastrointestinal malignancy. Basic science established a critical function for the intestinal microbiota in promoting tumorigenesis...
March 19, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29651797/pazopanib-induced-crystal-deposition-in-intestinal-mucosa-in-a-patient-with-retroperitoneal-liposarcoma
#11
Shigemitsu Horie, Hayato Nishida, Toshihiko Sakurai, Osamu Ichiyanagi, Tomoyuki Kato, Makoto Yagi, Takanobu Kabasawa, Teigo Asai, Norihiko Tsuchiya
Pazopanib was administered to a 44-year-old man with local recurrence of retroperitoneal liposarcoma. Computed tomography showed an intestinal edema, which gradually progressed 15 months after pazopanib administration although he had no clinical symptoms. Upper gastrointestinal endoscopy implicated marked edematous hypertrophy of the Kerkling's fold. Pathological findings showed crystal deposition and fat accumulation, without a malignant component. All these abnormal findings resolved after pazopanib discontinuation...
April 12, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29651403/enhanced-wound-healing-after-leiomyoma-enucleation
#12
Masood Amini, Mohammad Hassan Hashemizadeh, Seyedeh Leila Poorbaghi
Leiomyoma is a rare esophageal tumor that constitutes less than 1% of esophageal malignancies. It should be removed when diagnosed even if asymptomatic. This study presents two cases of esophageal leiomyoma in 38 and 62 years old men who presented with dysphagia and evaluated for diagnosis and location of related tumors. Patients were clinically examined and upper gastrointestinal endoscopy, chest computerized tomography scan, barium swallow and endoscopic ultrasonography were performed. The masses were diagnosed and both patients underwent 3-port right videothoracoscopic enucleation of esophageal leiomyoma with sleeve calibration tube (SCT) assistance...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29651051/collagen-iv-conveyed-signals-can-regulate-chemokine-production-and-promote-liver-metastasis
#13
George Vaniotis, Roni F Rayes, Shu Qi, Simon Milette, Ni Wang, Stephanie Perrino, France Bourdeau, Hanna Nyström, Yi He, Nathalie Lamarche-Vane, Pnina Brodt
Liver metastases remain a major cause of death from gastrointestinal tract cancers as well as from other malignancies such as breast and lung carcinomas and melanoma. Understanding the underlying biology is essential for the design of effective targeted therapies. We previously reported that collagen IV α1/α2 overexpression in non-metastatic lung carcinoma (M27colIV ) cells increased their metastatic ability, specifically to the liver and documented high collagen IV levels in surgical resections of liver metastases from diverse tumor types...
April 13, 2018: Oncogene
https://www.readbyqxmd.com/read/29650910/-the-actual-state-of-treatment-of-gastrointestinal-cancer-with-abdominal-aortic-aneurysm-in-our-department-over-the-past-five-years
#14
Masayuki Yubakami, Kenji Hiramatsu, Takuma Yamazaki, Yuichi Matsuzaki, Yu Houri, Nobuyuki Watanabe, Yutaka Kondo, Kazuto Ujiie, Yukihisa Nishimura, Momoko Todo, Yoshitaka Nakamura, Kiyoto Atsuji, Akihiro Yamaguchi, Hiroki Taniguchi
With the aging of the population of Japan and Westernization of the dietary life, the number of cases in which cardiovascular diseases are merged in non-cardiac surgery is increasing year by year.Many of the abdominal aortic aneurysms are asymptomatic and it is not uncommon to be discovered accidentally in preoperative examination of non-cardiac surgery.When gastrointestinal surgery involves malignant diseases of the gastrointestinal tract and abdominal aortic aneurysm, the two life prognosis-related diseases are merged, depending on the severity and urgency of the disease for each case, its treatment to determine the priority order...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650256/impact-of-route-and-adequacy-of-nutritional-intake-on-outcomes-of-allogeneic-haematopoietic-cell-transplantation-for-haematologic-malignancies
#15
Julie Beckerson, Richard M Szydlo, Mary Hickson, Catriona E Mactier, Andrew J Innes, Ian H Gabriel, Renuka Palanicawandar, Edward J Kanfer, Donald H Macdonald, Dragana Milojkovic, Amin Rahemtulla, Aristeidis Chaidos, Anastasios Karadimitris, Eduardo Olavarria, Jane F Apperley, Jiri Pavlu
BACKGROUND: Allogeneic haematopoietic cell transplantation (HCT) is often associated with poor oral intake due to painful mucositis and gastrointestinal sequalae that occur following a preparative regimen of intensive chemotherapy and/or total body radiation. Although attractive to assume that optimal nutrition improves HCT outcomes, there are limited data to support this. It is also unclear whether artificial nutrition support should be provided as enteral tube feeding or parenteral nutrition (PN)...
March 28, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29628985/clinical-characteristics-and-prognosis-associated-with-multiple-primary-cancers-in-breast-cancer-patients
#16
Bong Kyun Kim, Se Jeong Oh, Jeong-Yoon Song, Han-Byoel Lee, Min Ho Park, Yongsik Jung, Woo-Chan Park, Jina Lee, Woo Young Sun
Purpose: Breast cancer is one of the most common malignancies worldwide and the second most common cancer among Korean women. The prognosis of breast cancer is poor in patients with other primary cancers. However, there have been few clinical studies regarding this issue. Therefore, we analyzed the characteristics and prognosis of patients with breast cancer with multiple primary cancers (MPCs). Methods: Data from the Korean Breast Cancer Society Registry were analyzed...
March 2018: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29628470/a-rare-case-of-rush-progression-of-purulent-pericarditis-by-escherichia-coli-in-a-patient-with-malignant-lymphoma
#17
Shunpei Horii, Hirotaka Yada, Kei Ito, Ayumu Osaki, Atsushi Sato, Toyokazu Kimura, Risako Yasuda, Takumi Toya, Takayuki Namba, Nobuyuki Masaki, Takeshi Adachi
Purulent pericarditis is a rare disease in the antibiotic era. The common pathogens of purulent pericarditis are gram-positive species such as Staphylococcus aureus. Streptococcus pneumoniae, Salmonella, Haemophilus, fungal pathogens/tuberculosis can also result in purulent pericarditis. We report an old male case of purulent pericarditis by Escherichia coli. He came to our hospital suffering from leg edema for 3 months. Echocardiography revealed the large amount of pericardial effusion, and he was admitted to test the cause of pericardial effusion without high fever, tachycardia, and shock vital signs...
April 6, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29626802/laparoscopic-excision-of-a-retroperitoneal-completely-isolated-enteric-duplication-cyst-in-an-adult-male-a-case-report-and-review-of-literature
#18
Naoya Sasaki, Miru Okamura, Satoshi Kanto, Kentaro Tatsumi, Seiichi Yasuda, Atsushi Kawabe
INTRODUCTION: Duplication cysts are very rare congenital malformations in adults. They are lined by gastrointestinal mucosa, connect to the digestive tract, and share smooth muscular layers and a common blood supply. In rare cases, duplication cysts are completely isolated from the digestive tract and have a proper blood supply. Completely isolated duplication cysts in the retroperitoneum are unusual so it is hard to diagnose them without a surgical resection. PRESENTATION OF CASE: A 19-year-old male presented at our emergency department with sharp abdominal pain...
March 28, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29622808/expert-consensus-document-advances-in-the-diagnosis-and-classification-of-gastric-and-intestinal-motility-disorders
#19
REVIEW
Jutta Keller, Gabrio Bassotti, John Clarke, Phil Dinning, Mark Fox, Madhusudan Grover, Per M Hellström, Meiyun Ke, Peter Layer, Carolina Malagelada, Henry P Parkman, S Mark Scott, Jan Tack, Magnus Simren, Hans Törnblom, Michael Camilleri
Disturbances of gastric, intestinal and colonic motor and sensory functions affect a large proportion of the population worldwide, impair quality of life and cause considerable health-care costs. Assessment of gastrointestinal motility in these patients can serve to establish diagnosis and to guide therapy. Major advances in diagnostic techniques during the past 5-10 years have led to this update about indications for and selection and performance of currently available tests. As symptoms have poor concordance with gastrointestinal motor dysfunction, clinical motility testing is indicated in patients in whom there is no evidence of causative mucosal or structural diseases such as inflammatory or malignant disease...
April 6, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29622763/esophageal-mucosal-calcinosis-a-rare-site-of-gastrointestinal-mucosal-calcinosis
#20
Aaron R Huber, Brandon S Sprung, John Miller, Jennifer J Findeis-Hosey
BACKGROUND Gastrointestinal tract mucosal calcinosis (MC) tends to affect the gastric mucosa, while esophageal involvement is rare. Gastric MC may be seen with solid organ transplantation, use of aluminum-containing antacids or sucralfate, malignancy, and chronic renal failure. While the incidence of gastric MC in renal transplant patients undergoing gastric biopsy is common (between 15-29%), to our knowledge esophageal MC has only been previously reported 3 times. CASE REPORT A 68-year-old male dialysis-dependent end stage renal disease status-post deceased donor kidney transplant underwent an esophagogastroduodenoscopy (EGD) for dysphagia and diffuse esophageal wall thickening seen on imaging studies...
April 6, 2018: American Journal of Case Reports
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