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Dai Kamamoto, Kentaro Ohara, Yohei Kitamura, Kazunari Yoshida, Yutaka Kawakami, Hikaru Sasaki
BACKGROUND: Intracranial solitary fibrous tumor/hemangiopericytoma (SFT/HPC) often shows extracranial metastasis, and treatment options are very limited. Immune-checkpoint molecules have not been studied well in SFT/HPCs, and their role in intracranial SFT/HPCs remains unclear. METHODS: We investigated the expression of programmed cell death-1 (PD-1), programmed cell death ligand-1 (PD-L1), and tumor-infiltrating lymphocytes (TIL) in 16 patients of intracranial SFT/HPC by immunohistochemistry to determine if correlation with prognosis exists...
April 19, 2018: Journal of Neuro-oncology
Qing Peng, Mimin Zhang, Long Gao, Ojokoh Eromosele, Yu Qiao, Bo Shi
Alginate oligosaccharides (AOs) are linear oligosaccharides with alternating sequences of mannuronic acid (M) and guluronic acid (G) residues. AOs can be used as a safe elicitor to induce glyceollins, which have many human health benefits, in soybean seeds. In this research, four AO fractions with different chemical structures and molecular weights were separated, purified, and then characterized by NMR spectroscopy and ESI-MS. With a 4,5-unsaturated hexuronic acid residue (△) at the non-reducing terminus, the structures of these four AO fractions were △G, △MG, △GMG and △MGGG, which exhibited glyceollin-inducing activities of 1...
May 2018: Journal of Food Science and Technology
Kari M Gurtner, Eslam Shosha, Sandra C Bryant, Bruna D Andreguetto, David L Murray, Sean J Pittock, Maria Alice V Willrich
BACKGROUND: Cerebrospinal fluid (CSF) used in immunoglobulin gamma (IgG) index testing and oligoclonal bands (OCBs) are common laboratory tests used in the diagnosis of multiple sclerosis. The measurement of CSF free light chains (FLC) could pose as an alternative to the labor-intensive isoelectric-focusing (IEF) gels used for OCBs. METHODS: A total of 325 residual paired CSF and serum specimens were obtained after physician-ordered OCB IEF testing. CSF kappa (cKFLC) and lambda FLC (cLFLC), albumin and total IgG were measured...
February 19, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
John I McCormick, L Diana Berescu, Nabil Tadros
BACKGROUND: Public payer reimbursement for non-oncology drugs in Canada, including orphan drugs, is based on recommendations by the Common Drug Review (CDR) (with the exception of Quebec). CDR has been criticized for negative recommendations for orphan drugs and contributing to delays in patient access to these drugs. However, it is unclear how CDR makes recommendations for orphan drugs and the role clinical and economic factors play in decision making. The objective of the present study was to analyze the basis for CDR orphan drug recommendations and to compare recommendations to those in other jurisdictions...
January 30, 2018: Orphanet Journal of Rare Diseases
X Xiao, C Zhang, M Grigoroiu-Serbanescu, L Wang, L Li, D Zhou, T-F Yuan, C Wang, H Chang, Y Wu, Y Li, D-D Wu, Y-G Yao, M Li
Bipolar disorder (BPD), schizophrenia (SCZ) and unipolar major depressive disorder (MDD) are primary psychiatric disorders sharing substantial genetic risk factors. We previously reported that two single-nucleotide polymorphisms (SNPs) rs2709370 and rs6785 in the cAMP responsive element-binding (CREB)-1 gene (CREB1) were associated with the risk of BPD and abnormal hippocampal function in populations of European ancestry. In the present study, we further expanded our analyses of rs2709370 and rs6785 in multiple BPD, SCZ and MDD data sets, including the published Psychiatric Genomics Consortium (PGC) genome-wide association study, the samples used in our previous CREB1 study, and six additional cohorts (three new BPD samples, two new SCZ samples and one new MDD sample)...
November 21, 2017: Molecular Psychiatry
Lei Yin, Chong Su, Tianming Ren, Xiangjun Meng, Meiyun Shi, J Paul Fawcett, Mengliang Zhang, Wei Hu, Jingkai Gu
The covalent attachment of polyethylene glycol (PEG) to therapeutic compounds (known as PEGylation) is one of the most promising techniques to improve the biological efficacy of small molecular weight drugs. After administration, PEGylated prodrugs can be metabolized into pharmacologically active compounds so that PEGylated drug, free drug and released PEG are present simultaneously in the body. Understanding the pharmacokinetic behavior of these three compounds is needed to guide the development of pegylated theranostic agents...
October 12, 2017: Analyst
Xueyun Huo, Xiaoqin Xiao, Shuangyue Zhang, Deshan Zhou, Zhenwen Chen
BACKGROUND/AIM: Microsatellite instability (MSI) is a hallmark of genomic instability. In gastric cancer (GC), MSI phenotype is an important molecular subgroup that is often closely correlated with elevated mutation rates on the whole genome level. However, on a single gene level, it is still unknown whether the MSI status of a gene is correlated with the mutational profile of the gene itself. MATERIALS AND METHODS: We analyzed intron MSI status and exon mutational profile of TP53 through short tandem repeat (STR) scanning and direct sequencing respectively in gastric cancers and their matched normal tissues...
August 2017: Anticancer Research
J Duan
PURPOSE: In this study, texture analysis is proposed to assess liver cirrhosis and normal liver in CT image, and to automatically identify cirrhosis tissue and normal tissue for liver. METHODS: Texture feature parameters were extracted from 10 liver cirrhosis and 10 normal liver CT images. To individuate which parameter is available in classify the different tissue, a Wilcoxon signed-rank test between textural indices was performed. RESULTS: We acquired 9 texture parameters (such as energy, inertia, entropy, correlation, etc...
June 2016: Medical Physics
Xiulu Ruan, Alan David Kaye
Chronic pain is pervasive and costly. In 2011, the Institute of Medicine (IOM) released a landmark report on chronic pain, which estimated that more than 100 million Americans suffer from chronic pain, making pain a major and significant public health problem. The benefits of interdisciplinary pain management programs are undeniable and have been demonstrated for over a half century. Until health care leaders and other stakeholders such as insurers work together to ensure best practices in pain management, we will certainly end up in a lose-lose situation for both the health care teams and patients...
December 2016: Journal of Orthopaedic and Sports Physical Therapy
Fatemeh Amininajafi, Mohammad Reza Mehrara, Arman Hosseini, Rooholla Fattahi, Mehdi Taghizadeh, Sardar Hasanzadeh
[This retracts the article DOI: 10.1007/s12639-014-0611-7.].
2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
K H Park, S Lee, J H Park, S Y Kang, H Y Kim, I H Park, Y H Park, Y H Im, H J Lee, S Park, S I Lee, K H Jung, Y S Kim, Jae Hong Seo
PURPOSE: This multi-center, randomized, phase III study was conducted to demonstrate the non-inferiority of DA-3031 compared with daily filgrastim in patients during the first cycle of chemotherapy for breast cancer in terms of the duration of severe neutropenia (DSN). METHODS: Seventy-four patients with breast cancer who were receiving combination chemotherapy with docetaxel, doxorubicin, and cyclophosphamide (TAC) were enrolled. All participants were randomized to receive either daily subcutaneous injections of filgrastim 100 μg/m(2)/day for up to 10 days or a single subcutaneous injection of DA-3031 at fixed doses of 6 mg on day 2 of each chemotherapy cycle...
February 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Jong-Oh Kim, Jae-Ok Kim, Wi-Sik Kim, Myung-Joo Oh
OBJECTIVE: To develop the rapid and efficient quantitative detection tool for nervous necrosis virus isolated from sevenband grouper Hyporhodus septemfasciatus. METHODS: The viral genes of the NNV (SGYeosu08) isolated from sevenband grouper were phylogenetically analyzed. In addition, novel quantitative PCR primers based on the genomic sequence of SGYeosu08 isolate were designed and compared it with the conventional bio-assay method (TCID50) using in vitro and in vivo samples...
August 2016: Asian Pacific Journal of Tropical Medicine
Giuseppina Novo, Girolamo Manno, Rosario Russo, Dario Buccheri, Sonia Dell'Oglio, Pierluigi Morreale, Giovanna Evola, Giustina Vitale, Salvatore Novo
BACKGROUND: Insulin resistance (IR), constitutes an important cardiovascular risk factor and can cause ischemic heart disease. It can lead to left ventricular dysfunction with a mechanism independent of ischemic heart disease and it is closely associated with impaired vascular function. The aim of our study was to explore the impact of IR on cardiac and vascular function, in patients with cardiovascular risk factors but angiographically undamaged coronary arteries. METHODS: We studied 32 patients (62...
October 15, 2016: International Journal of Cardiology
Tomasz Kleszczewski, Ewa Kleszczewska, Leszek Buzun, Beata Modzelewska
BACKGROUND: The aim of this study was the simultaneous determination of levels of cadmium and l-ascorbic Acid (AA) in human saphenous vein (SV) used in coronary artery bypass grafting (CABG) and check whether there is a relationship between these levels. METHODS: Human SV were collected from 40 patients (20 men and 20 women; age, 40-75 years) at the time of routine coronary artery surgical revascularization. The concentration of cadmium in the tissue was determined according to the GF AAS-atomic absorption method...
July 2016: Journal of Trace Elements in Medicine and Biology
Xianjuan Shen, Yan Ye, Jing Qi, Wei Shi, Xinhua Wu, Hongbing Ni, Hui Cong, Shaoqing Ju
BACKGROUND: miRNAs act in diverse biological processes including development, cell growth, apoptosis, and hematopoiesis, suggesting their role in cancer. METHODS: We examined the miRNAs perturbed in CD138+ primary multiple myeloma (MM) cells, using microarray analysis and real-time quantitative PCR (RT-qPCR). Serum miR-4449 expression levels were detected from 71 primary MM patients and 46 healthy controls by RT-qPCR. RESULTS: Our analysis revealed up-regulation of 54 and down-regulation of 28 miRNAs in MM subjects compared to healthy controls...
May 1, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
Florian von Knobelsdorff-Brenkenhoff, Achudhan Karunaharamoorthy, Ralf Felix Trauzeddel, Alex J Barker, Edyta Blaszczyk, Michael Markl, Jeanette Schulz-Menger
BACKGROUND: Aortic stenosis (AS) leads to variable stress for the left ventricle (LV) and consequently a broad range of LV remodeling. The aim of this study was to describe blood flow patterns in the ascending aorta of patients with AS and determine their association with remodeling. METHODS AND RESULTS: Thirty-seven patients with AS (14 mild, 8 moderate, 15 severe; age, 63±13 years) and 37 healthy controls (age, 60±10 years) underwent 4-dimensional-flow magnetic resonance imaging...
March 2016: Circulation. Cardiovascular Imaging
Xiaoguang Chen, Ruobin Dai, Xinyi Xiang, Gang Li, Zhengqi Xu, Tao Hu, Awad Abdelgadir
The shock resistance characteristic (SRC) of an anaerobic bioreactor characterizes the ability of the anaerobic community in the reactor to withstand violent change in the living environment. In comparison with an upflow anaerobic sludge blanket reactor (UASBR), the SRC of a spiral symmetry stream anaerobic bio-reactor (SSSAB) was systematically investigated in terms of removal efficiency, adsorption property, settling ability, flocculability and fluctuations in these parameters. A quantitative assessment method for SRC was also developed...
2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Richard Philip Lee, Claire Bamford, Catherine Exley, Louise Robinson
BACKGROUND: Dementia, of all long term illnesses, accounts for the greatest chronic disease burden, and the number of people with age-related diseases like dementia is predicted to double by 2040. People with advanced dementia experience similar symptoms to those dying with cancer yet professional carers find prognostication difficult and struggle to meet palliative care needs, with physical symptoms undetected and untreated. While elements of good practice in this area have been identified in theory, the factors which enable such good practice to be implemented in real world practice need to be better understood...
July 25, 2015: BMC Palliative Care
Andrew N Norris
We consider a periodic lattice structure in d=2 or 3 dimensions with unit cell comprising Z thin elastic members emanating from a similarly situated central node. A general theoretical approach provides an algebraic formula for the effective elasticity of such frameworks. The method yields the effective cubic elastic constants for three-dimensional space-filling lattices with Z=4, 6, 8, 12 and 14, the last being the 'stiffest' lattice proposed by Gurtner & Durand (Gurtner & Durand 2014 Proc. R. Soc. A 470, 20130611...
December 8, 2014: Proceedings. Mathematical, Physical, and Engineering Sciences
Kristina L Blanke, James C Sacco, Robert C Millikan, Andrew F Olshan, Jingchun Luo, Lauren A Trepanier
PURPOSE: Cytochrome b 5 (encoded by CYB5A) and NADH cytochrome b 5 reductase (encoded by CYB5R3) detoxify aromatic and heterocyclic amine mammary carcinogens found in cigarette smoke. We hypothesized that CYB5A and CYB5R3 polymorphisms would be associated with breast cancer risk in women. METHODS: We characterized the prevalence of 18 CYB5A and CYB5R3 variants in genomic DNA from African American (AfrAm) and Caucasian (Cauc) women from the Carolina Breast Cancer Study population (1,946 cases and 1,747 controls) and determined their associations with breast cancer risk, with effect modification by smoking...
November 2014: Cancer Causes & Control: CCC
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