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K H Park, S Lee, J H Park, S Y Kang, H Y Kim, I H Park, Y H Park, Y H Im, H J Lee, S Park, S I Lee, K H Jung, Y S Kim, Jae Hong Seo
PURPOSE: This multi-center, randomized, phase III study was conducted to demonstrate the non-inferiority of DA-3031 compared with daily filgrastim in patients during the first cycle of chemotherapy for breast cancer in terms of the duration of severe neutropenia (DSN). METHODS: Seventy-four patients with breast cancer who were receiving combination chemotherapy with docetaxel, doxorubicin, and cyclophosphamide (TAC) were enrolled. All participants were randomized to receive either daily subcutaneous injections of filgrastim 100 μg/m(2)/day for up to 10 days or a single subcutaneous injection of DA-3031 at fixed doses of 6 mg on day 2 of each chemotherapy cycle...
October 6, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Jong-Oh Kim, Jae-Ok Kim, Wi-Sik Kim, Myung-Joo Oh
OBJECTIVE: To develop the rapid and efficient quantitative detection tool for nervous necrosis virus isolated from sevenband grouper Hyporhodus septemfasciatus. METHODS: The viral genes of the NNV (SGYeosu08) isolated from sevenband grouper were phylogenetically analyzed. In addition, novel quantitative PCR primers based on the genomic sequence of SGYeosu08 isolate were designed and compared it with the conventional bio-assay method (TCID50) using in vitro and in vivo samples...
August 2016: Asian Pacific Journal of Tropical Medicine
Giuseppina Novo, Girolamo Manno, Rosario Russo, Dario Buccheri, Sonia Dell'Oglio, Pierluigi Morreale, Giovanna Evola, Giustina Vitale, Salvatore Novo
BACKGROUND: Insulin resistance (IR), constitutes an important cardiovascular risk factor and can cause ischemic heart disease. It can lead to left ventricular dysfunction with a mechanism independent of ischemic heart disease and it is closely associated with impaired vascular function. The aim of our study was to explore the impact of IR on cardiac and vascular function, in patients with cardiovascular risk factors but angiographically undamaged coronary arteries. METHODS: We studied 32 patients (62...
October 15, 2016: International Journal of Cardiology
Tomasz Kleszczewski, Ewa Kleszczewska, Leszek Buzun, Beata Modzelewska
BACKGROUND: The aim of this study was the simultaneous determination of levels of cadmium and l-ascorbic Acid (AA) in human saphenous vein (SV) used in coronary artery bypass grafting (CABG) and check whether there is a relationship between these levels. METHODS: Human SV were collected from 40 patients (20 men and 20 women; age, 40-75 years) at the time of routine coronary artery surgical revascularization. The concentration of cadmium in the tissue was determined according to the GF AAS-atomic absorption method...
July 2016: Journal of Trace Elements in Medicine and Biology
Xianjuan Shen, Yan Ye, Jing Qi, Wei Shi, Xinhua Wu, Hongbing Ni, Hui Cong, Shaoqing Ju
BACKGROUND: miRNAs act in diverse biological processes including development, cell growth, apoptosis, and hematopoiesis, suggesting their role in cancer. METHODS: We examined the miRNAs perturbed in CD138+ primary multiple myeloma (MM) cells, using microarray analysis and real-time quantitative PCR (RT-qPCR). Serum miR-4449 expression levels were detected from 71 primary MM patients and 46 healthy controls by RT-qPCR. RESULTS: Our analysis revealed up-regulation of 54 and down-regulation of 28 miRNAs in MM subjects compared to healthy controls...
May 6, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
Florian von Knobelsdorff-Brenkenhoff, Achudhan Karunaharamoorthy, Ralf Felix Trauzeddel, Alex J Barker, Edyta Blaszczyk, Michael Markl, Jeanette Schulz-Menger
BACKGROUND: Aortic stenosis (AS) leads to variable stress for the left ventricle (LV) and consequently a broad range of LV remodeling. The aim of this study was to describe blood flow patterns in the ascending aorta of patients with AS and determine their association with remodeling. METHODS AND RESULTS: Thirty-seven patients with AS (14 mild, 8 moderate, 15 severe; age, 63±13 years) and 37 healthy controls (age, 60±10 years) underwent 4-dimensional-flow magnetic resonance imaging...
March 2016: Circulation. Cardiovascular Imaging
Xiaoguang Chen, Ruobin Dai, Xinyi Xiang, Gang Li, Zhengqi Xu, Tao Hu, Awad Abdelgadir
The shock resistance characteristic (SRC) of an anaerobic bioreactor characterizes the ability of the anaerobic community in the reactor to withstand violent change in the living environment. In comparison with an upflow anaerobic sludge blanket reactor (UASBR), the SRC of a spiral symmetry stream anaerobic bio-reactor (SSSAB) was systematically investigated in terms of removal efficiency, adsorption property, settling ability, flocculability and fluctuations in these parameters. A quantitative assessment method for SRC was also developed...
2016: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Richard Philip Lee, Claire Bamford, Catherine Exley, Louise Robinson
BACKGROUND: Dementia, of all long term illnesses, accounts for the greatest chronic disease burden, and the number of people with age-related diseases like dementia is predicted to double by 2040. People with advanced dementia experience similar symptoms to those dying with cancer yet professional carers find prognostication difficult and struggle to meet palliative care needs, with physical symptoms undetected and untreated. While elements of good practice in this area have been identified in theory, the factors which enable such good practice to be implemented in real world practice need to be better understood...
2015: BMC Palliative Care
Andrew N Norris
We consider a periodic lattice structure in d=2 or 3 dimensions with unit cell comprising Z thin elastic members emanating from a similarly situated central node. A general theoretical approach provides an algebraic formula for the effective elasticity of such frameworks. The method yields the effective cubic elastic constants for three-dimensional space-filling lattices with Z=4, 6, 8, 12 and 14, the last being the 'stiffest' lattice proposed by Gurtner & Durand (Gurtner & Durand 2014 Proc. R. Soc. A 470, 20130611...
December 8, 2014: Proceedings. Mathematical, Physical, and Engineering Sciences
Kristina L Blanke, James C Sacco, Robert C Millikan, Andrew F Olshan, Jingchun Luo, Lauren A Trepanier
PURPOSE: Cytochrome b 5 (encoded by CYB5A) and NADH cytochrome b 5 reductase (encoded by CYB5R3) detoxify aromatic and heterocyclic amine mammary carcinogens found in cigarette smoke. We hypothesized that CYB5A and CYB5R3 polymorphisms would be associated with breast cancer risk in women. METHODS: We characterized the prevalence of 18 CYB5A and CYB5R3 variants in genomic DNA from African American (AfrAm) and Caucasian (Cauc) women from the Carolina Breast Cancer Study population (1,946 cases and 1,747 controls) and determined their associations with breast cancer risk, with effect modification by smoking...
November 2014: Cancer Causes & Control: CCC
Se-Eun Jang, Myung Joo Han, Se-Young Kim, Dong-Hyun Kim
The TNF-α expression-inhibitory effect of lactic acid bacteria (LAB) isolated from kimchi were measured in lipopolysaccharide (LPS)-stimulated peritoneal macrophages. Among the LAB evaluated, Lactobacillus plantarum CLP-0611 inhibited the IL-1β and IL-6 expression, as well as the NF-κB and AP1 activation in LPS-stimulated peritoneal macrophages. Therefore, we investigated its inhibitory effect on 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice. TNBS significantly induced colon shortening, as well as myeloperoxidase activity and macroscopic score...
July 2014: International Immunopharmacology
Andra V Krauze, Minhee Won, Christian Graves, Ben W Corn, Thierry M Muanza, Steven P Howard, Arul Mahadevan, Christopher J Schultz, Michael L Haas, Minesh P Mehta, Kevin A Camphausen
BACKGROUND: Glioblastoma Multiforme (GBM) is the most common primary malignant tumor of the central nervous system. Standard of care includes maximal resection followed by chemoradiotherapy. Tumors need adequate perfusion and neovascularization to maintain oxygenation and for removal of wastes. Vascular endothelial growth factor (VEGF) is a well characterized pro-angiogenic factor. We hypothesized that the increases in urinary VEGF levels would occur early in the course of tumor recurrence or progression...
2013: Biomarker Research
Chun-Chuan Shih, Hsun-Hua Lee, Ta-Liang Chen, Chin-Chuan Tsai, Hsin-Long Lane, Wen-Ta Chiu, Chien-Chang Liao
Background. Little research exists on acupuncture treatment's effect on patients with traumatic brain injury (TBI). Methods. Using Taiwan's National Health Insurance Research Database, we conducted a cohort study to compare the use of emergency care and hospitalization in TBI patients with and without acupuncture treatment in the first year after TBI. The adjusted relative risks (RRs) and 95% confidence intervals (CIs) of high use of emergency care and hospitalization associated with acupuncture treatment were calculated in multivariate Poisson regression models with generalized estimating equation...
2013: Evidence-based Complementary and Alternative Medicine: ECAM
Qian Zhao, Ping Yan, Lei Yin, Ling Li, Xue Qi Chen, Chao Ma, Rong Fu Wang
Tumor angiogenesis is important in the growth and metastasis of malignant tumors. In our previous study, we demonstrated that an arginine-arginine-leucine (RRL) peptide is a tumor endothelial cell-specific binding sequence that may be used as a molecular probe for the imaging of malignant tumors in vivo. The aim of the present study was to further explore the characteristics of 131I‑RRL by biodistribution tests, and to estimate the radiation dosimetry of 131I‑RRL for humans using mice data. The RRL peptide was radiolabeled with 131I by a chloramine-T (CH-T) method...
April 2013: Molecular Medicine Reports
Ying Guo, Pei-fang Li, Xiao-chun Shu, Huan Deng, Hai-li Ma, Liao Sun
OBJECTIVE: To explore the effects of the expression of Wnt/β-catenin signaling factor mRNA during drynaria total flavonoids on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). METHODS: The BMSCs were isolated from SD rats by whole bone marrow culture method and purified by passage. And the P3 BMSCs were intervened with 100 µg/ml drynaria total flavonoids. At Day 21, mineralized staining was performed. At Days 7, 14, 21 and 28 post-intervention, the activity of alkaline phosphatase (ALP) was detected and polymerase chain reaction (PCR) used to detect the expressions of Wnt/β-catenin signaling pathway related factors β-catenin, LEF-1 and cycline D mRNA...
August 28, 2012: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Eisha Manak, Aman Arora
To compare the temperature changes in the pulpal chamber during fabrication of provisional restorations by direct method. A total of 108 three-unit FPD provisional restorations were fabricated on a study model and divided into three main groups according to the material used for the fabrication of matrix. Group A-Alginate impression index group, Group B-Polyvinylsiloxane putty impression index group, Group C-Vacuum formed template group. Each group comprising of 36 specimens, was subdivided into three subgroups based on the provisional restorative material used: polymethylmethacrylate (subgroup 1), polyethylmethacrylate (subgroup 2), bis-acryl composite resin (subgroup 3)...
September 2011: Journal of Indian Prosthodontic Society
Rong-min Gu, Xu Wen, Da Wei, Xue-zhi Ming, Gang Li, Huan-qiu Chen
OBJECTIVE: To investigate the effect of hyperthermic intraoperative intraperitoneal chemotherapy(HIIC) and postoperative nutritional support on the intestinal permeability and the cellular immunity function in patients with advanced gastric cancer. METHODS: All the patients diagnosed as advanced gastric cancer in the Gastric Tumor Diagnosis and Treatment Center of Jiangsu Cancer Hospital were randomly divided into three groups using random digit table:(1)EN group treated with enteral nutrition during postoperative period; (2)HIIC+EN group treated with HIIC combined with postoperative enteral nutrition;(3)HIIC+PN group treated with HIIC combined with postoperative parenteral nutrition...
May 2012: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Asad E Patanwala, Christopher J Edwards, Lori Stolz, Richard Amini, Amol Desai, Uwe Stolz
OBJECTIVE: To determine if patient weight is predictive of the degree of analgesic response to morphine in opioid naïve patients in the emergency department (ED). DESIGN: Prospective observational study. SETTING: Academic, tertiary ED, designated as a level 1 trauma center. PATIENTS: Fifty opioid naive adult patients who were administered a single fixed intravenous dose of 4 mg morphine on initial presentation to the ED...
January 2012: Journal of Opioid Management
Tsuyoshi Ikehara, Shihoko Imamura, Atsushi Yoshino, Takeshi Yasumoto
Okadaic acid and its analogs (OAs) responsible for diarrhetic shellfish poisoning (DSP) strongly inhibit protein phosphatase 2A (PP2A) and thus are quantifiable by measuring the extent of the enzyme inhibition. In this study, we evaluated the suitability of the catalytic subunit of recombinant human PP2A (rhPP2Ac) for use in a microplate OA assay. OA, dinophysistoxin-1(DTX1), and hydrolyzate of 7-O-palmitoyl-OA strongly inhibited rhPP2Ac activity with IC(50) values of 0.095, 0.104, and 0.135 nM, respectively...
January 2010: Toxins
Rafael O P de Campos, Vasco Heredia, Miguel Ramalho, Marcos S De Toni, Aida Lugo-Somolinos, Edwin R Fuller, Richard C Semelka
OBJECTIVE: The purpose of this study is to evaluate the feasibility of 0.025 mmol/kg gadobenate dimeglumine, which is one quarter of the standard dose, for abdominal 3-T MRI studies in patients considered to be at risk for nephrogenic systemic fibrosis, using qualitative and quantitative measures and comparison with higher doses. MATERIALS AND METHODS: The MRI database was retrospectively searched to select consecutive patients who underwent quarter-dose gadobenate dimeglumine-enhanced abdominal MRI at 3 T, between January 1, 2009, and January 15, 2010, and who underwent half-dose (0...
March 2011: AJR. American Journal of Roentgenology
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