keyword
MENU ▼
Read by QxMD icon Read
search

Amfepramone

keyword
https://www.readbyqxmd.com/read/27201685/cost-effectiveness-analysis-of-amfepramone-diethylpropion-for-the-obesity-treatment-in-mexico
#1
Molina H Soto, Martínez J P Díaz, Juárez Y Escobar, Del Valle C Fernández
No abstract text is available yet for this article.
November 2014: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27201640/a-double-blind-controlled-study-of-the-efficacy-and-safety-of-long-acting-amfepramone-treatment-in-mexican-obese-patients
#2
Molina H Soto, Castellanos M Pizarro, Perez J Rosado, Cordoba A Rizzoli, Del Valle C Fernández, García J G Reyes
No abstract text is available yet for this article.
November 2014: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27006262/clustering-and-diagnostic-modelling-of-slimming-aids-based-on-chromatographic-and-mass-spectrometric-fingerprints
#3
D Custers, E Van Hoeck, P Courselle, S Apers, E Deconinck
Herbal medicines and food supplements intended as slimming aids are increasingly gaining popularity worldwide, especially for treating obesity. In this study, an ultra-performance liquid chromatography coupled to photodiode array detection (UPLC-PDA) and an ultra-performance liquid chromatography mass spectrometry (UPLC-MS) method were developed to analyze 92 slimming aids (confiscated by customs), aimed at acquiring highly informative fingerprints. Three types of fingerprints were acquired (PDA, Total Ion Chromatograms (TIC), and MS fingerprints) which were used in the chemometric data analysis...
March 22, 2016: Drug Testing and Analysis
https://www.readbyqxmd.com/read/26760907/development-of-an-analytical-method-for-simultaneous-detection-of-psychotropic-phenylalkylamines-in-hair-by-lc-ms-ms-with-a-multi-mode-reversed-phase-column-using-ph-gradient-elution
#4
Hyeyoung Choi, Suncheun Kim, Suyoun Ahn, Hyejin Chang, Sangki Lee, Yongmoon Lee
Phenylalkylamine derivatives, such as methamphetamine (MA), 3,4-methylenedioxymethamphetamine (MDMA), phentermine, fenfluramine, phendimetrazine, amfepramone, and ketamine, are widely abused recreational or anorectic drugs in Korea, and their abuse has become a serious social problem. Hair is a useful specimen to prove chronic use and liquid chromatography-tandem mass spectrometry (LC-MS/MS) has recently become a more popular tool for hair analysis due to sensitivity and simplicity in sample preparation. In order to overcome limitations of standard reversed-phase column to separate low molecular weight amines, we adopted a multi-mode reversed-phase column, Scherzo SS-C18, which was composed of strong ionic ligands and C18 ligands, and used pH gradient elution to separate seven psychotropic phenylalkylamines and their metabolites...
February 2016: Forensic Science International
https://www.readbyqxmd.com/read/26718151/validation-and-application-of-a-liquid-chromatography-electrospray-ionization-mass-spectrometric-method-for-determination-of-mazindol-in-human-plasma-and-urine
#5
Marcella Herbstrith de Oliveira, Pâmela Cristina Lukasewicz Ferreira, Graciela Carlos, Fernanda Rodrigues Salazar, Ana Maria Bergold, Flavio Pechansky, Renata Pereira Limberger, Pedro Eduardo Fröehlich
INTRODUCTION: Even after removal of some stimulants, like fenproporex, amfepramone and mazindol, from Brazilian market, the use of these substances is still high, especially by drivers. Mazindol is the second most used anorectic agent in the world acting as an indirect sympathomimetic agonist, having stimulatory action on central nervous system. Plasma is a good matrix to monitor since it reflects the psychomotor effects of these drugs, but unlike urine has an invasive collection; drug levels and detection time are quite low...
May 2016: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/26659026/n-bromosuccinimide-promoted-and-base-switchable-one-pot-synthesis-of-%C3%AE-imido-and-%C3%AE-amino-ketones-from-styrenes
#6
Mahesh H Shinde, Umesh A Kshirsagar
An N-Bromosuccinimide (NBS) promoted one pot strategy for the synthesis of α-amino functionalized aryl ketones starting from commercially available styrenes has been developed. NBS participates in multiple tasks, such as bromonium ion formation, oxidation of bromohydrin and providing a nucleophilic nitrogen source. The reaction can easily be switched between α-imido and α-amino ketones by the choice of base. This one pot strategy was successfully applied for the synthesis of psychoactive drug candidates, amfepramone, mephedrone and 4-MEC...
January 21, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/26073353/six-month-efficacy-and-safety-of-amfepramone-in-obese-mexican-patients-a-double-blinded-randomized-controlled-trial
#7
RANDOMIZED CONTROLLED TRIAL
Herman Soto-Molina, Mariel Pizarro-Castellanos, Juana Rosado-Pérez, Antonio Rizzoli-Córdoba, Eleazar Lara-Padilla, Cecilia Fernández del Valle-Laisequilla, Juan Gerardo Reyes-García
Amfepramone, also known as diethylpropion, is an anorectic drug used for the short-term treatment of obesity; however, its efficacy and safety during periods greater than 3 months has been scarcely studied. To evaluate the 6-month efficacy and safety of amfepramone treatment in obese adult Mexican patients resistant to diet and exercise, a double-blinded, randomized, and placebo-controlled clinical trial study was designed on 156 volunteers with a body mass index (BMI) greater than 30 kg/m2 and less than 45 kg/m2...
July 2015: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/25831200/mechanisms-involved-in-the-vasorelaxant-effects-produced-by-the-acute-application-of-amfepramone-in-vitro-to-rat-aortic-rings
#8
J S López-Canales, J Lozano-Cuenca, E Muãoz-Islas, J C Aguilar-Carrasco, O A López-Canales, R M López-Mayorga, E F Castillo-Henkel, I Valencia-Hernández, C Castillo-Henkel
Amfepramone (diethylpropion) is an appetite-suppressant drug used for the treatment of overweight and obesity. It has been suggested that the systemic and central activity of amfepramone produces cardiovascular effects such as transient ischemic attacks and primary pulmonary hypertension. However, it is not known whether amfepramone produces immediate vascular effects when applied in vitro to rat aortic rings and, if so, what mechanisms may be involved. We analyzed the effect of amfepramone on phenylephrine-precontracted rat aortic rings with or without endothelium and the influence of inhibitors or blockers on this effect...
June 2015: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/25633934/a-versatile-and-one-pot-strategy-to-synthesize-%C3%AE-amino-ketones-from-benzylic-secondary-alcohols-using-n-bromosuccinimide
#9
Somraj Guha, Venkatachalam Rajeshkumar, Surya Srinivas Kotha, Govindasamy Sekar
A metal-free one-pot strategy has been developed for the first time to synthesize pharmaceutically important α-amino ketones from readily available benzylic secondary alcohols and amines using N-bromosuccinimide. This new reaction proceeds via three consecutive steps involving oxidation of alcohols, α-bromination of ketones, and nucleophilic substitution of α-bromo ketones to give α-amino ketones. Importantly, this novel one-pot greener reaction avoids direct usage of toxic and corrosive bromine. This methodology has been employed efficiently to synthesize pharmaceutically important amfepramone and pyrovalerone in a single step...
February 6, 2015: Organic Letters
https://www.readbyqxmd.com/read/25153984/transition-metal-free-oxidative-%C3%AE-c-h-amination-of-ketones-via-a-radical-mechanism-mild-synthesis-of-%C3%AE-amino-ketones
#10
Qing Jiang, Bin Xu, An Zhao, Jing Jia, Tian Liu, Cancheng Guo
A transition-metal-free direct α-C-H amination of ketones has been developed using commercially available ammonium iodide as the catalyst and sodium percarbonate as the co-oxidant. A wide range of ketone ((hetero)aromatic or nonaromatic ketones) and amine (primary/secondary amines, anilines, or amides) substrates undergo cross-coupling to generate synthetically useful α-amino ketones. The mechanistic studies indicated that a radical pathway might be involved in the reaction process. The utility of the method is highlighted through a concise one-step synthesis of the pharmaceutical agent amfepramone...
September 19, 2014: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/24897204/-are-there-irrationalities-in-the-consumption-of-anti-obesity-drugs-in-brazil-a-pharmaco-econometric-analysis-of-panel-datasets
#11
Daniel Marques Mota, Márcia Gonçalves de Oliveira, Rafael Filiacci Bovi, Sidarta Figueredo Silva, Jeane Araújo Fernandes Cunha, José Angelo Divino
The scope of this study is to analyze the determinants of the use of appetite suppressants (amfepramone, femproporex, mazindol and sibutramine) through the estimation of a dynamic panel dataset model for the Brazilian state capitals and the Federal District (DF) in the period from 2009 to 2011. The results show that consumption of appetite suppressants did not follow the geographic distribution of overweight and obese individuals across the capitals and DF. There is a recurrent consumption of appetite inhibitors, in which 79% of the current consumption of these drugs is explained by past consumption...
May 2014: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/24829782/identification-and-determination-of-synthetic-pharmaceuticals-as-adulterants-in-eight-common-herbal-weight-loss-supplements
#12
Marjan Khazan, Mehdi Hedayati, Farzad Kobarfard, Sahar Askari, Fereidoun Azizi
BACKGROUND: Adulterated herbal weight loss products with containing undeclared synthetic drugs are common and responsible for many serious health damages. OBJECTIVES: The purpose of the study was to determine five synthetic adulterants in eight common herbal weight loss supplements, which are currently sold in Iran markets, to verify their presence in supplements, without mentioning on the labels. MATERIALS AND METHODS: Eight common herbal weight loss samples were obtained from the Iran pharmaceutical market after advertising in the Persian language on satellite channels and internet...
March 2014: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/24458547/determination-of-mazindol-in-human-oral-fluid-by-high-performance-liquid-chromatography-electrospray-ionization-mass-spectrometry
#13
Marcella Herbstrith de Oliveira, Graciela Carlos, Ana Maria Bergold, Flavio Pechansky, Renata Pereira Limberger, Pedro Eduardo Fröehlich
Brazil is one of the countries most affected by abuse of stimulant medications by professional drivers, especially fenproporex, amfepramone and mazindol. Even though their sale is banned, they can be found in illegal markets, such as those located on the country's borders. The use of oral fluid to monitor drug levels has many advantages over plasma and urine because it is noninvasive, easier to collect and more difficult to adulterate. The aim of this study was to develop and validate a sensitive and specific method to quantify mazindol in human oral fluid by liquid chromatography-mass spectrometry (LC-MS)...
August 2014: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/24274153/use-of-buccal-micronucleus-assay-to-determine-mutagenicity-induced-by-amfepramone-in-humans-and-the-protective-effects-of-vitamin-c
#14
Marisa Fernanda da Silva Nunes, Roberta da Silva Nunes, Vívian Francília Silva Kahl, Juliana Moysés Reyes, Juliana da Silva
The abusive use of amfepramone in Brazilian population has grown in recent years. Few studies have been conducted on amphetamine with respect to DNA damage, and there have been no apparent investigations examining the influence of amfepramone on humans. The aim of this study was to determine the possible mutagenic actions of amfepramone on humans using the micronucleus (MN) assay with buccal cells and the effects of supplementation with vitamin C as a potential protective agent. The study included 108 females with 52 as control and 56 taking amfepramone at 120 mg/d for at least the whole previous month...
January 2013: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/24107144/simple-catalytic-mechanism-for-the-direct-coupling-of-%C3%AE-carbonyls-with-functionalized-amines-a-one-step-synthesis-of-plavix
#15
Ryan W Evans, Jason R Zbieg, Shaolin Zhu, Wei Li, David W C MacMillan
The direct α-amination of ketones, esters, and aldehydes has been accomplished via copper catalysis. In the presence of catalytic copper(II) bromide, a diverse range of carbonyl and amine substrates undergo fragment coupling to produce synthetically useful α-amino-substituted motifs. The transformation is proposed to proceed via a catalytically generated α-bromo carbonyl species; nucleophilic displacement of the bromide by the amine then delivers the α-amino carbonyl adduct while the catalyst is reconstituted...
October 30, 2013: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/23782322/determination-of-diuretics-and-laxatives-as-adulterants-in-herbal-formulations-for-weight-loss
#16
Ana Paula Lançanova Moreira, Monique Jung Motta, Thaís Ramos Dal Molin, Carine Viana, Leandro Machado de Carvalho
A new method is described for the determination of the most common diuretic and laxative adulterants found in formulations of anorexics and antidepressants. The method is based on the separation of furosemide, hydrochlorothiazide, chlorthalidone and amiloride (diuretics), phenolphthalein (laxative), amfepramone (anorexic) and fluoxetine and paroxetine (antidepressants) by capillary zone electrophoresis with capacitively coupled contactless conductivity detection. The method showed a precision ranging from 1...
2013: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/23600228/-simultaneous-determination-of-six-adulterants-in-functional-foods-by-high-performance-liquid-chromatography-with-diode-array-detection
#17
Feng Xue, Yang Li, Yuan Wang, Yong Xue, Cheng-Jun Sun
OBJECTIVE: To establish a method for simultaneous determination of six adulterants including norpseudoephedrine (NPE), pseudoephedrine (PSE), amfepramone (AMF), strychnine (STR), fenfluramine (FEN) and sildenafil (SIL) in functional foods by high performance liquid chromatography with diode array detection (HPLC-DAD). METHODS: Food samples were treated with 2% formic acid ultrasonically, and then the extracts were cleaned-up with solid phase extraction (SPE) with strong cation exchange cartridges (SCX)...
January 2013: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/23579743/the-use-of-appetite-suppressants-among-health-sciences-undergraduate-students-in-southern-brazil
#18
Carlos Zubaran, Rubia Lazzaretti
OBJECTIVE: To investigate the prevalence of appetite suppressant use among health sciences students in Southern Brazil. METHODS: Undergraduate students (n=300) from seven health science undergraduate courses of the Universidade de Caxias do Sul completed a questionnaire about the use of substances to suppress appetite. RESULTS: A significant percentage (15%; n=45) of research participants used appetite suppressants at least once in their lives...
January 2013: Einstein
https://www.readbyqxmd.com/read/23537731/vulnerability-to-dietary-n-3-polyunsaturated-fatty-acid-deficiency-after-exposure-to-early-stress-in-rats
#19
Charles Francisco Ferreira, Juliana Rombaldi Bernardi, Rachel Krolow, Danusa Mar Arcego, Gabriel Rodrigo Fries, Bianca Wollenhaupt de Aguiar, Gabrielle Senter, Flávio Pereira Kapczinski, Patrícia Pelufo Silveira, Carla Dalmaz
The exposure to adverse events early in life may affect brain development. Omega-3 polyunsaturated fatty acid (n-3 PUFA) deficiency has been linked to the development of mood and anxiety disorders. The aim of this study was to examine the interaction between variations in the early environment (handling or maternal separation) and the chronic exposure to a nutritional n-3 PUFA deficiency on locomotor activity, sucrose preference, forced swimming test and on serum and hippocampal brain-derived neurotrophic factor (BDNF) levels...
June 2013: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/23511002/first-trimester-in-utero-exposure-to-anorectics-a-french-collaborative-study-with-special-reference-to-dexfenfluramine
#20
T Vial, E Robert, P Carlier, E Bertolotti, A Brun
A collaborative study with 8 Teratology Information Centres was undertaken to collect data on anorectic exposures (amfepramone, clobenzorex, dexfenfluramine, fenfluramine, fenproporex) during pregnancy. Two hundred and ninety seven prospective enquiries were analysed of which 285 exposures occurred during the first trimester. Outcome of pregnancy was known for 164 of these cases. Voluntary or medical abortion was decided in 30 cases (18%), spontaneous abortion occurred in 14 cases (8.5%), extrauterine pregnancy in 1 patient and fetal death following drug abuse in another...
1992: International Journal of Risk & Safety in Medicine
keyword
keyword
113519
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"