Vera Battini, Sara Rocca, Greta Guarnieri, Anna Bombelli, Michele Gringeri, Giulia Mosini, Marco Pozzi, Maria Nobile, Sonia Radice, Emilio Clementi, Antonio Schindler, Carla Carnovale, Nicole Pizzorni
Background: Polypharmacy is common in patients with dysphagia. Routinely used drugs may influence swallowing function either improving or worsening it. We aimed to explore the potential effects of three commonly used drug classes on dysphagia and aspiration pneumonia through a systematic review and a real-world data analysis to probe the possibility of drug repurposing for dysphagia treatment. Material and Methods: Five electronic databases were searched. Studies on adults at risk for dysphagia, treated with Dipeptidyl-Peptidase IV Inhibitors (DPP-4i), Adrenergic Beta-Antagonists (beta-blockers), or Angiotensin-Converting Enzyme Inhibitors (ACEi), and reporting outcomes on dysphagia or aspiration pneumonia were included...
2023: Frontiers in Pharmacology