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A Arias, O A Peters, I L Broyles
AIM: To develop, implement and evaluate an innovative curriculum in biostatistics in response to the needs of fostering critical thinking in graduate health care education for evidence-based practice and life-long learning education. METHODOLOGY: The curriculum was designed for first-year residents in a postgraduate endodontic program using a six-step approach to curriculum development to provide sufficient understanding to critically evaluate biomedical publications, to design the best research strategy to address a specific problem and to analyse data by appropriate statistical test selection...
October 26, 2016: International Endodontic Journal
I B Beloglazova, E S Zubkova, Z I Tsokolaeva, Yu S Stafeev, K V Dergilev, E I Ratner, M V Shestakova, O Yu Sukhareva, E V Parfenova, M Yu Men'shikov
We studied the effect of urokinase, its recombinant forms, and domain fragments on migration and proliferation of adipose tissue mesenchymal stromal cells (MSCs) and MMP secretion by these cells. Urokinase, but not its recombinant forms, slightly induced directed migration of MSCs. Spontaneous migration of MSCs increased under the action of urokinase or its isolated kringle domain. Migration induced by platelet-derived growth factor was inhibited by proteolytically inactive form of urokinase, the kringle domain, and blocking antibody to urokinase receptor...
October 26, 2016: Bulletin of Experimental Biology and Medicine
L I Kolesnikova, B Ya Vlasov, S I Kolesnikov, M A Darenskaya, L A Grebenkina, N V Semenova, O A Vanteeva
Specific features of LPO were studied in Mongoloid and Caucasian patients with type 1 diabetes mellitus. The intensity of LPO in Mongoloid patients was lower than in Caucasians: the level of primary and intermediate products was by lower 1.53 and 1.83 times, while total antioxidant activity was elevated by 1.44 times, which was also supported by oxidative stress coefficient (1.35 in Mongoloids and 2.32 in Caucasians). These differences suggest that differentiated approach is required for the treatment of these patients...
October 26, 2016: Bulletin of Experimental Biology and Medicine
I V Chekhonin, O I Gurina, S A Cherepanov, M A Abakumov, K P Ionova, D K Zhigarev, A V Makarov, V P Chekhonin
We obtained the morphologically, cytofluorometrically, and functionally mature dendritic cells from rats that were pulsed with antigens of the C6 glioma tissue extract. The concentrations of angiogenesis antigens (VEGF, VEGFR-1, and VEGFR-2) and periglioma zone proteins (GFAP, connexin 43, and BSAT1) in the pulsing extract were measured by ELISA. Our results drove us to a conclusion that despite mature phenotype of pulsed dendritic cell, the antigenic composition of glioma tissue extracts should be modified...
October 26, 2016: Bulletin of Experimental Biology and Medicine
A G Emelianova, I P Shilovskii, M S Sundukova, M R Khaitov, O I Epshtein
Antiviral activity of Ergoferon was studied in vitro on an experimental model of rotavirus infection in MA-104 cell line. In infected cells treated with Ergoferon, rotavirus titer was shown to decrease by 83 and 90% in comparison with cells treated with solvent used for Ergoferon preparation (p<0.05) and distilled water (p<0.05), respectively. These findings demonstrate high anti-rotavirus activity of Ergoferon.
October 26, 2016: Bulletin of Experimental Biology and Medicine
Yurinskaya M M, Kochetkova O Yu, Shabarchina L I, Antonova O Yu, Suslikov A V, Evgen'ev M B, Vinokurov M G
Human heat shock protein Hsp70 was experimentally inserted into polyelectrolyte microcapsules. Encapsulated recombinant Hsp70 was studied in terms of its effects on neutrophil apoptosis, the production of reactive oxygen species, and the secretion of tumor necrosis factor alpha by promonocytic THP-1 cells. It was found that encapsulated Hsp70 effectively inhibits neutrophil apoptosis, unlike free exogenous protein used in solution. In THP-1 cells, encapsulated and free Hsp70 reduced LPS-induced tumor necrosis factor alpha production with a similar efficiency...
October 26, 2016: Cell Stress & Chaperones
Amos O Adelowo, Michele R Hacker, Anna M Modest, Costa A Apostolis, Anthony J Disciullo, Katherine J Hanaway, Eman E Elkadry, Peter L Rosenblatt, Kathleen J Rogers, Lekha S Hota
OBJECTIVE: To compare mechanical bowel preparation (MBP) using oral magnesium citrate with sodium phosphate enema to sodium phosphate (NaP) enema alone during minimally invasive pelvic reconstructive surgery. METHODS: We conducted a single-blind, randomized controlled trial of MBP versus NaP in women undergoing minimally invasive pelvic reconstructive surgery. The primary outcome was intraoperative quality of the surgical field. Secondary outcomes included surgeon assessment of bowel handling and patient-reported tolerability symptoms...
October 25, 2016: Female Pelvic Medicine & Reconstructive Surgery
D Möncke, E I Kamitsos, D Palles, R Limbach, A Winterstein-Beckmann, T Honma, Z Yao, T Rouxel, L Wondraczek
A series of transition and post-transition metal ion (Mn, Cu, Zn, Pb, Bi) binary borate glasses was studied with special consideration of the cations impact on the borate structure, the cations cross-linking capacity, and more generally, structure-property correlations. Infrared (IR) and Raman spectroscopies were used for the structural characterization. These complementary techniques are sensitive to the short-range order as in the differentiation of tetrahedral and trigonal borate units or regarding the number of non-bridging oxygen ions per unit...
September 28, 2016: Journal of Chemical Physics
Yohanna Seminovski, Polina Tereshchuk, Adam Kiejna, Juarez L F Da Silva
Finite site platinum particles, Ptn, supported on reduced or unreduced cerium oxide surfaces, i.e., CeO2-x(111) (0<x<12), have been employed and studied as catalysts for a wide range of applications, which includes hydrogen production using the ethanol steam reforming processes. Our atomic-level understanding of the interaction of Pt with CeO2-x has been improved in the last years; however, the identification of the active sites on the Ptn/CeO2-x(111) substrates is still far from complete. In this work, we applied density functional theory based calculations with the addition of the on-site Coulomb interactions (DFT+U) for the investigation of the active sites and the role of the Pt oxidation state on the adsorption properties of water and ethanol (probe molecules) on four selected substrates, namely, Pt(111), Pt4/Pt(111), CeO2(111), and Pt4/CeO2(111)...
September 28, 2016: Journal of Chemical Physics
O Tarvainen, J Orpana, R Kronholm, T Kalvas, J Laulainen, H Koivisto, I Izotov, V Skalyga, V Toivanen
The efficiency of the microwave-plasma coupling plays a significant role in the production of highly charged ion beams with electron cyclotron resonance ion sources (ECRISs). The coupling properties are affected by the mechanical design of the ion source plasma chamber and microwave launching system, as well as damping of the microwave electric field by the plasma. Several experiments attempting to optimize the microwave-plasma coupling characteristics by fine-tuning the frequency of the injected microwaves have been conducted with varying degrees of success...
September 2016: Review of Scientific Instruments
M Y Pustylnik, M A Fink, V Nosenko, T Antonova, T Hagl, H M Thomas, A V Zobnin, A M Lipaev, A D Usachev, V I Molotkov, O F Petrov, V E Fortov, C Rau, C Deysenroth, S Albrecht, M Kretschmer, M H Thoma, G E Morfill, R Seurig, A Stettner, V A Alyamovskaya, A Orr, E Kufner, E G Lavrenko, G I Padalka, E O Serova, A M Samokutyayev, S Christoforetti
New complex-plasma facility, Plasmakristall-4 (PK-4), has been recently commissioned on board the International Space Station. In complex plasmas, the subsystem of μm-sized microparticles immersed in low-pressure weakly ionized gas-discharge plasmas becomes strongly coupled due to the high (10(3)-10(4) e) electric charge on the microparticle surface. The microparticle subsystem of complex plasmas is available for the observation at the kinetic level, which makes complex plasmas appropriate for particle-resolved modeling of classical condensed matter phenomena...
September 2016: Review of Scientific Instruments
S Schmuck, J Fessey, J E Boom, L Meneses, P Abreu, E Belonohy, I Lupelli
At the tokamak Joint European Torus (JET), the electron cyclotron emission spectra in O-mode and X-mode polarisations are diagnosed simultaneous in absolute terms for several harmonics with two Martin-Puplett interferometers. From the second harmonic range in X-mode polarisation, the electron temperature profile can be deduced for the outboard side (low magnetic field strength) of JET but only for some parts of the inboard side (high magnetic field strength). This spatial restriction can be bypassed, if a cutoff is not present inside the plasma for O-mode waves in the first harmonic range...
September 2016: Review of Scientific Instruments
Jared O Kafader, Josey E Topolski, Caroline Chick Jarrold
The anion photoelectron (PE) spectra of Ce2Oy(-) (y = 1, 2), Ce3Oy(-) (y = 0-4), Ce4Oy(-) (y = 0-2), and Ce5Oy(-) (y = 1, 2) are reported and analyzed with supporting results from density functional theory calculations. The PE spectra all exhibit an intense electronic transition to the neutral ground state, all falling in the range of 0.7 to 1.1 eV electron binding energy, with polarization dependence consistent with detachment from diffuse Ce 6s-based molecular orbitals. There is no monotonic increase in electron affinity with increasing oxidation...
October 21, 2016: Journal of Chemical Physics
Sunan Kitjaruwankul, Channarong Khrutto, Pornthep Sompornpisut, B L Farmer, R B Pandey
Structure of CorA protein and its inner (i.corA) and outer (o.corA) transmembrane (TM) components are investigated as a function of temperature by a coarse-grained Monte Carlo simulation. Thermal response of i.corA is found to differ considerably from that of the outer component, o.corA. Analysis of the radius of gyration reveals that the inner TM component undergoes a continuous transition from a globular conformation to a random coil structure on raising the temperature. In contrast, the outer transmembrane component exhibits an abrupt (nearly discontinuous) thermal response in a narrow range of temperature...
October 7, 2016: Journal of Chemical Physics
Miren Larrañaga, M Mounir Bou-Ali, Estela Lapeira, Ion Lizarraga, Carlos Santamaría
In the present work, we have measured the thermodiffusion coefficient of 51 binary liquid mixtures at 25 (o)C. These mixtures correspond to the series of the aromatics toluene and 1-methylnaphthalene with n-alkanes nCi (i = 6, 8, 10, 12, and 14) at different mass fractions in the whole range. For that, we have used the thermogravitational technique. It is shown that the thermodiffusion coefficient is a linear function of the mass fraction in all the mixtures. Extrapolating the lines, we obtain the thermodiffusion coefficient in dilute solutions of n-alkanes for both toluene and 1-methylnaphthalene...
October 7, 2016: Journal of Chemical Physics
Niklas O Thiel, Johannes F Teichert
An air-stable and preactivated copper(i) hydroxide/N-heteroyclic carbene (NHC) complex for alkyne semihydrogenations is reported. Next to an enhanced practicability of the process, the resulting alkenes are obtained with high Z-selectivities and no overreduction to the corresponding alkanes.
October 26, 2016: Organic & Biomolecular Chemistry
J Bruffaerts, D Pierrot, I Marek
The molding of molecules through remote functionalisation has increasingly become popular as it provides original and flexible synthetic alternatives to classical retrosynthetic analysis. In this Perspective article, we summarise more than a decade of studies in the specific field of remote activation of inert C-C and C-O bonds using the unique abilities of organozirconocene species mainly from our own research group. By demonstrating that these reactions represent novel and powerful entries towards acyclic stereodefined reactive organometallic species, we aim to show the vast opportunities this concept-driven methodology discovery offers...
October 26, 2016: Organic & Biomolecular Chemistry
Renee B Y Lee, Despoina A I Mavridou, Grigorios Papadakos, Harry L O McClelland, Rosalind E M Rickaby
Unicellular phytoplanktonic algae (coccolithophores) are among the most prolific producers of calcium carbonate on the planet, with a production of ∼10(26) coccoliths per year. During their lith formation, coccolithophores mainly employ coccolith-associated polysaccharides (CAPs) for the regulation of crystal nucleation and growth. These macromolecules interact with the intracellular calcifying compartment (coccolith vesicle) through the charged carboxyl groups of their uronic acid residues. Here we report the isolation of CAPs from modern day coccolithophores and their prehistoric predecessors and we demonstrate that their uronic acid content (UAC) offers a species-specific signature...
October 26, 2016: Nature Communications
I Khan, O E Okosieme, J H Lazarus
Thyroid dysfunction is common in pregnancy and has adverse fetal and maternal health consequences. A number of challenges in the management of gestational thyroid dysfunction remain unresolved including uncertainties in optimal thresholds for correction of hypothyroidism and strategies for pharmacological management of hyperthyroidism. Areas covered: We addressed key challenges and areas of uncertainty in the management of thyroid dysfunction in pregnancy. Expert commentary: Gestational thyroid hormone reference intervals vary according to population ethnicity, iodine nutrition, and assay method and each population should derive trimester specific reference intervals for use in pregnancy...
October 26, 2016: Expert Review of Clinical Pharmacology
A Caiazzo, F Caforio, G Montecinos, L O Muller, P J Blanco, E F Toro
This work presents a detailed investigation of a parameter estimation approach based on the reduced order unscented Kalman filter (ROUKF) in the context of one-dimensional blood flow models. In particular, the main aims of this study are (i) to investigate the effects of using real measurements versus synthetic data for the estimation procedure (i.e., numerical results of the same in silico model, perturbed with noise) and (ii) to identify potential difficulties and limitations of the approach in clinically realistic applications in order to assess the applicability of the filter to such setups...
October 25, 2016: International Journal for Numerical Methods in Biomedical Engineering
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