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JOURNAL ARTICLE
Soo Heon Kwak, Ryan B Hernandez-Cancela, Daniel A DiCorpo, David E Condon, Jordi Merino, Peitao Wu, Jennifer A Brody, Jie Yao, Xiuqing Guo, Fariba Ahmadizar, Mariah Meyer, Murat Sincan, Josep M Mercader, Sujin Lee, Jeffrey Haessler, Ha My T Vy, Zhaotong Lin, Nicole D Armstrong, Shaopeng Gu, Noah L Tsao, Leslie A Lange, Ningyuan Wang, Kerri L Wiggins, Stella Trompet, Simin Liu, Ruth J F Loos, Renae Judy, Philip H Schroeder, Natalie R Hasbani, Maxime M Bos, Alanna C Morrison, Rebecca D Jackson, Alexander P Reiner, JoAnn E Manson, Ninad S Chaudhary, Lynn K Carmichael, Yii-Der Ida Chen, Kent D Taylor, Mohsen Ghanbari, Joyce van Meurs, Achilleas N Pitsillides, Bruce M Psaty, Raymond Noordam, Ron Do, Kyong Soo Park, J Wouter Jukema, Maryam Kavousi, Adolfo Correa, Stephen S Rich, Scott M Damrauer, Catherine Hajek, Nam H Cho, Marguerite R Irvin, James S Pankow, Girish N Nadkarni, Robert Sladek, Mark O Goodarzi, Jose C Florez, Daniel I Chasman, Susan R Heckbert, Charles Kooperberg, Josée Dupuis, Rajeev Malhotra, Paul S de Vries, Ching-Ti Liu, Jerome I Rotter, James B Meigs
OBJECTIVE: To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: We conducted a multiancestry time-to-event genome-wide association study for incident CVD among people with T2D. We also tested 204 known coronary artery disease (CAD) variants for association with incident CVD. RESULTS: Among 49,230 participants with T2D, 8,956 had incident CVD events (event rate 18...
April 23, 2024: Diabetes Care
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JOURNAL ARTICLE
Georgia M Wong, Ashley McCray, Kara Hom, Saige Teti, Nathan T Cohen, William D Gaillard, Chima O Oluigbo
INTRODUCTION: Stereoelectroencephalography (SEEG) is valuable for delineating the seizure onset zone (SOZ) in pharmacoresistant epilepsy when non-invasive presurgical techniques are inconclusive. Secondary epilepsy surgery after initial failure is challenging and there is limited research on SEEG following failed epilepsy surgery in children. OBJECTIVE: The objective of this manuscript is to present the outcomes of children who underwent SEEG after failed epilepsy surgery...
April 23, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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JOURNAL ARTICLE
N Kumar, N V Surovtsev, P A Yunin, D V Ishchenko, I A Milekhin, S P Lebedev, A A Lebedev, O E Tereshchenko
BSTS epitaxial thin film topological insulators were grown using the MBE technique on two different types of substrates i.e. , Si (111) and SiC/graphene with Bi0.7 Sb1.6 Te1.8 Se0.9 and Bi0.9 Sb1.5 Te1.8 Se1.1 , respectively. The crystallographic properties of BSTS films were investigated via X-ray diffraction, which showed the strongest reflections from the (0 0 l ) facets corresponding to the rhombohedral phase. Superior epitaxial growth, homogeneous thickness, smooth surfaces, and larger unit cell parameters were observed for the films grown on the Si substrate...
April 23, 2024: Physical Chemistry Chemical Physics: PCCP
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JOURNAL ARTICLE
Ian Dance
In converting N2 to NH3 the enzyme nitrogenase utilises 8 electrons and 8 protons in the complete catalytic cycle. The source of the electrons is an Fe4 S4 reductase protein (Fe-protein) which temporarily docks with the MoFe-protein that contains the catalytic active cofactor, FeMo-co, and an electron transfer cluster called the P cluster. The overall mechanism involves 8 repetitions of a cycle in which reduced Fe-protein docks with the MoFe-protein, one electron transfers to the P-cluster, and then to FeMo-co, followed by dissociation of the two proteins and re-reduction of the Fe-protein...
April 23, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
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JOURNAL ARTICLE
A Korneev I, I Apolikhin O, Yu Babenko A, V Bogo-Lyubov S, A Bozhedomov V, V Vinogradov I, A Gazimiev M, I Gamidov S, A Efremov E, A Epanchint-Seva E, B Zhukov O, A Kamalov A, A Kinunen A, I Kogan M, S Korsak V, S Krasnyak S, V Moiseeva I, I Ovchinnikov R, S Petrishchev V, S Rogozin D, T Savzikhanov R, B Chernykh V, V Shurygina O
A review of controversial issues about the terminology on male infertility and reproductive function, which is currently used, as well as proposals for updating clinical guidelines for the diagnosis and treatment of male infertility and men in infertile couples are presented in the article. An algorithm is described, the elements of which ensure referral of patients based on the possibility and timing of restoration of reproductive function, taking into account the reproductive health of a woman, as well as increasing the likelihood of successful treatment aimed at the birth of a healthy child...
March 2024: Urologii︠a︡
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JOURNAL ARTICLE
[Non-transecting anastomotic urethroplasty for strictures of the bulbar urethra. Systematic review].
I Katibov M, B Bogdanov A, I Veliev E, B Laurent O
The results of using non-transecting anastomotic urethroplasty in men with bulbous urethral strictures are presented in the review. A total of 25 original publications were found, including 20 foreign and 5 Russian articles. The studies included from 1 to 358 patients who underwent anastomotic urethroplasty without transection of the corpus spongiosum (average number of patients in a study was 54). Etiological factors were indicated in 17 articles. Most studies (10 out of 17) indicated idiopathic etiology as the predominant one...
March 2024: Urologii︠a︡
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JOURNAL ARTICLE
A Gyaurgiev T, V Kuzmenko A, V KuzmenkoV, V Zolotukhin O, Yu Madykin Yu, I Avdeev A
INTRODUCTION: Immune defense mechanisms, including a decrease in the functional activity of monocytes/macrophages, neutrophils, as well as a violation of the balance of pro- and anti-inflammatory cytokines, are important in the development of chronic abacterial prostatitis (CAP). The discovery of the cytokine system and the determination of their biological role in the development and functioning of the immune system and in the pathogenesis of a wide range of human diseases led to the development of a new direction in immunotherapy - cytokine therapy...
March 2024: Urologii︠a︡
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JOURNAL ARTICLE
I Besprozvannyj V, N Shatokhin M, M Kholimenko I, V Teodorovich O, A Konoplja N, Ju Mavrin M
AIM: To determine the effect of standard treatment on changes in the structural and functional properties of erythrocytes in obstructive and non-obstructive acute pyelonephritis. MATERIALS AND METHODS: The structural and functional properties of erythrocytes and their intracellular metabolism in 78 patients with a diagnosis of primary non-obstructive and secondary obstructive acute pyelonephritis, randomized by age, gender, and the minimum number of concomitant diseases were investigated...
March 2024: Urologii︠a︡
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JOURNAL ARTICLE
V Protoshchak V, N Orlov D, V Paronnikov M, G Karpushchenko E
AIM: To improve the results of treatment of patients with urolithiasis who underwent endoscopic interventions using a ureteral access sheath (UAS) by developing a predictive model of ureteral dilatation without pre-stenting. MATERIALS AND METHODS: A total of 180 patients with kidney stones up to 20 mm were included in the study. They were divided into two groups: in the group 1 (n=79) UAS of 12/14 Ch was used, while in group II (n=101) UAS of 10/12 Ch was inserted...
March 2024: Urologii︠a︡
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JOURNAL ARTICLE
E Karasev A, I Bresso T, D Markova O, R Kasyan G, Yu Pushkar D
AIM: To assess the quality of life of patients with interstitial cystitis (IC) and to study effective options used to control symptoms on outpatient basis. MATERIALS AND METHODS: The results of a descriptive prospective cross-sectional cohort study are presented. The medical charts of patients who were treated in the City Clinical Hospital named after Spasokukotsky from 2021 to 2023 were analyzed. Eighty inpatient medical charts of various patients with a final diagnosis of IC with Hunner's lesion were identified...
March 2024: Urologii︠a︡
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JOURNAL ARTICLE
Grace Hahm, Frenio A Redeker, Kaveh Jorabchi
Prevalence of F, Cl, S, P, Br, and I in pharmaceuticals and environmental contaminants has promoted standard-free quantitation using analyte-independent heteroatom responses in inductively coupled plasma (ICP)-MS. However, in-plasma ionization challenges and element-dependent isobaric interference removal methods have hampered the multielement nonmetal detection in ICP-MS. Here, we examine an alternative approach to enhance multielement detection capabilities. Analytes are introduced into an ICP leading to post-plasma formation of HF, HCl, H3 PO3 , H2 SO4 , HBr, and HI, which are then chemically ionized to BaF+ , BaCl+ , BaH2 PO3 + , BaHSO4 + , BaBr+ , and BaI+ via reactions with barium-containing ions supplied by a nanospray...
April 22, 2024: Journal of the American Society for Mass Spectrometry
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JOURNAL ARTICLE
Mahmoud Shaban, Fahad Nasser Alsunaydih, Hanan Kouta, Samar El-Sanabary, Abdulrahman Alrumayh, Abdulrahman I Alateyah, Majed O Alawad, Waleed H El-Garaihy, Yasmine El-Taybany
The present research applies different statistical analysis and machine learning (ML) approaches to predict and optimize the processing parameters on the wear behavior of ZK30 alloy processed through equal channel angular pressing (ECAP) technique. Firstly, The ECAPed ZK30 billets have been examined at as-annealed (AA), 1-pass, and 4-passes of route Bc (4Bc). Then, the wear output responses in terms of volume loss (VL) and coefficient of friction (COF) have been experimentally investigated by varying load pressure (P) and speed (V) using design of experiments (DOE)...
April 22, 2024: Scientific Reports
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JOURNAL ARTICLE
Shruti Shah, Kamatham Pushpa Tryphena, Gurpreet Singh, Amrita Kulkarni, Poojitha Pinjala, Dharmendra Kumar Khatri
Parkinson's disease (PD) is a multifactorial neurodegenerative disorder whose cause is unclear. Neuroinflammation is recognized as one of the major pathogenic mechanisms involved in the development and progression of PD. NLRP3 inflammasome is the most widely studied inflammatory mediator in various diseases including PD. Several phytoconstituents have shown neuroprotective role in PD. Carvacrol is a phenolic monoterpene commonly found in the essential oils derived from plants belonging to Lamiaceae family. It is well known for its anti-inflammatory and antioxidant properties and has been widely explored in several diseases...
April 20, 2024: Brain Research
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JOURNAL ARTICLE
O Aniekwe, T Jolaiya, A Ajayi, I A Adeleye, M Gerhard, S I Smith
Helicobacter pylori and intestinal parasites cause gastrointestinal diseases with a high prevalence in children in resource limited developing countries. There is paucity of information in Nigeria on co-infection of H. pylori and intestinal parasites. The study was conducted to determine the prevalence of H. pylori and parasite co-infection in children from selected low-income communities in Lagos, Nigeria. Fecal samples were collected from 151 healthy children aged ≤11 years across six low-income communities in Lagos...
April 20, 2024: Parasitology International
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JOURNAL ARTICLE
Pim A de Jong, Netanja I Harlianto, Wouter Foppen, Nağme Ö Renkli, Wilko Spiering, Harrie Weinans, Willem PThM Mali, Simon C Mastbergen, Mylène P Jansen
OBJECTIVES: Ectopic bone deposition plays an important role in osteoarthritis (OA) and in arterial wall disease. We aimed to investigate the prevalence and progression of arterial calcifications on whole-body computed tomography (CT) in persons with knee OA. METHODS: We included 118 (36 male) participants who satisfied the clinical American College of Rheumatology classification criteria for knee OA. Baseline investigations included Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Kellgren-Lawrence grading...
April 22, 2024: Rheumatology
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JOURNAL ARTICLE
O Vymazal, I Papatheodorou, I Andrejčinová, V Bosáková, G Vascelli, K Bendíčková, T Zelante, M Hortová-Kohoutková, J Frič
Calcineurin - nuclear factor of activated T-cell (CN-NFAT) inhibitors are widely clinically used drugs for immunosuppression but besides their required T-cell response inhibition, they also undesirably affect innate immune cells. Disruption of innate immune cell function can explain the observed susceptibility of CN-NFAT inhibitors-treated patients to opportunistic fungal infections. Neutrophils play an essential role in innate immunity as a defense against pathogens, however, the effect of CN-NFAT inhibitors on neutrophil function was poorly described...
April 22, 2024: Journal of Leukocyte Biology
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JOURNAL ARTICLE
Sophie Mayer, Alexander Bergen, Ziwen Zhai, Simon Trzeciak, Junyu Chu, Dirk Zahn, Thomas M Koller, Karsten Meyer, Nicolas Vogel
In this study, we systematically analyze the surface tension and Hansen solubility parameters (HSPs) of imidazolium-based ionic liquids (ILs) with different anions ([NTf2 ]- , [PF6 ]- , [I]- , and [Br]- ). These anions are combined with the classical 1-alkyl-3-methyl-substituted imidazolium cations ([C n C1 Im]+ ) and a group of oligoether-functionalized imidazolium cations ([(mPEG n )2 Im]+ ) based on methylated polyethylene glycol (mPEG n ). In detail, the influences of the length of the alkyl- and the mPEG n -chain, the anion size, and the water content are investigated experimentally...
April 22, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
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JOURNAL ARTICLE
Nallagatla Vinod Kumar, Gajanan Sawargaonkar, C Sudha Rani, Rajesh Pasumarthi, Santhosh Kale, T Ram Prakash, S Triveni, Ajay Singh, Moses Shyam Davala, Rohan Khopade, Rayapati Karthik, Bathula Venkatesh, Mandapelli Sharath Chandra
Crop residues in agriculture pose disposal challenges and contribute to air pollution when burned. This study aims to use pigeonpea and maize stalks to produce biochar at different pyrolysis temperatures. Biochar can serve in carbon sequestration, as a soil amendment, and as an alternative fuel source. Pyrolysis was conducted at 400, 500, and 600 °C to examine the effects on physicochemical properties, fuel, and energy related properties. Increase in temperatures resulted in decrease of biochar yield, volatile matter, and O/C and H/C atomic ratios, while ash content and essential nutrients increased...
January 3, 2024: Bioresources and Bioprocessing
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JOURNAL ARTICLE
C O Bamigboye, O E Akinola, J D Adegboye, I A Fadiora, I O Omomowo, O N Majolagbe, O R Oyeleke, A A Alarape, T K Ojediran, M D Shittu, J K Oloke
This study examined the effects of using mushroom mycelium to ferment tigernut and cassava pulp on the growth performance, haematology and immunology of rabbits. Seventy-five New Zealand Bulk grower rabbits were randomly distributed to four treatment groups and a control group in a completely randomized approach. The treatment groups were fed with formulated experimental diets containing one of fermented tigernut drink by-product (FT), fermented cassava sievate (FC), unfermented tigernut drink by-product (UT), or unfermented cassava sievate (UC)...
April 22, 2024: Tropical Animal Health and Production
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JOURNAL ARTICLE
April H Bailey, Robin Dembroff, Daniel Wodak, Elif G Ikizer, Andrei Cimpian
Pronouns often convey information about a person's social identity (e.g., gender). Consequently, pronouns have become a focal point in academic and public debates about whether pronouns should be changed to be more inclusive, such as for people whose identities do not fit current pronoun conventions (e.g., gender nonbinary individuals). Here, we make an empirical contribution to these debates by investigating which social identities lay speakers think that pronouns should encode (if any) and why. Across four studies, participants were asked to evaluate different types of real and hypothetical pronouns, including binary gender pronouns, race pronouns, and identity-neutral pronouns...
May 2024: Journal of Experimental Psychology. General
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