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https://www.readbyqxmd.com/read/29156594/chemical-transformations-in-proto-cytoplasmic-media-phosphorus-coupling-in-the-silica-hydrogel-phase
#1
Ian B Gorrell, Timothy W Henderson, Kamal Albdeery, Philip M Savage, Terence P Kee
It has been proposed that prebiotic chemical studies on the emergence of primitive life would be most relevant when performed in a hydrogel, rather than an aqueous, environment. In this paper we describe the ambient temperature coupling of phosphorus oxyacids [Pi] mediated by Fe(II) under aerobic conditions within a silica hydrogel (SHG) environment. We have chosen to examine SHGs as they have considerable geological precedence as key phases in silicification en route to rock formation. Following a description of the preparation and characterization studies on our SHG formulations, coupling experiments between Pi species are described across multiple permutations of (i) Pi compound; (ii) gel formulation; (iii) metal salt additive; and (iv) pH-modifying agent...
November 19, 2017: Life
https://www.readbyqxmd.com/read/29156328/role-of-hair-pigmentation-in-drug-incorporation-into-hair
#2
Hyerim Yu, Won-Jun Jang, Jung-Hee Jang, Byoungduck Park, Young Ho Seo, Chul-Ho Jeong, Sooyeun Lee
Hair analysis has notably expanded its application as a bio-monitor for drug or toxicant exposure. Hair pigmentation is proposed as a major factor affecting drug incorporation into hair; however, the mechanisms underlying the incorporation of drugs into hair are still unclear. In the present study, the effect of hair pigmentation on drug incorporation into hair was examined using rats carrying hair with different melanin status and human cells (SK-Mel-28 cells, HaCaT cells and the co-cultured HaCaT cells with SK-Mel-28 cells) representing the main pigmentary unit in hair...
November 11, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29156223/exploring-apoe-genotype-effects-on-ad-risk-and-%C3%AE-amyloid-burden-in-individuals-with-subjective-cognitive-decline-the-facehbi-study-baseline-results
#3
Sonia Moreno-Grau, O Rodríguez-Gomez, A Sanabria, A Perez-Cordon, D Sanchez-Ruiz, C Abdelnour, S Valero, I Hernandez, M Rosende-Roca, A Mauleon, L Vargas, A Lafuente, S Gil, M A Santos-Santos, M Alegret, A Espinosa, G Ortega, M Guitart, A Gailhajanet, I de Rojas, O Sotolongo-Grau, S Ruiz, N Aguilera, J Papasey, E Martin, E Peleja, F Lomeña, F Campos, A Vivas, M Gomez-Chiari, M A Tejero, J Giménez, M Serrano-Ríos, A Orellana, L Tarraga, A Ruiz, M Boada
INTRODUCTION: Subjective cognitive decline (SCD) has been proposed as a potential preclinical stage of Alzheimer's disease (AD). Nevertheless, the genetic and biomarker profiles of SCD individuals remain mostly unexplored. METHODS: We evaluated apolipoprotein E (APOE) Ɛ4's effect in the risk of presenting SCD, using the Fundacio ACE Healthy Brain Initiative (FACEHBI) SCD cohort and Spanish controls, and performed a meta-analysis addressing the same question. We assessed the relationship between APOE dosage and brain amyloid burden in the FACEHBI SCD and Alzheimer's Disease Neuroimaging Initiative cohorts...
November 17, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29156000/structural-rearrangements-in-mrna-upon-its-binding-to-human-80s-ribosomes-revealed-by-epr-spectroscopy
#4
Alexey A Malygin, Dmitri M Graifer, Maria I Meschaninova, Alya G Venyaminova, Ivan O Timofeev, Andrey A Kuzhelev, Olesya A Krumkacheva, Matvey V Fedin, Galina G Karpova, Elena G Bagryanskaya
The model mRNA (MR), 11-mer RNA containing two nitroxide spin labels at the 5'- and 3'-terminal nucleotides and prone to form a stable homodimer (MR)2, was used for Electron Paramagnetic Resonance study of structural rearrangements in mRNA occurring upon its binding to human 80S ribosomes. The formation of two different types of ribosomal complexes with MR was observed. First, there were stable complexes where MR was fixed in the ribosomal mRNA-binding channel by the codon-anticodon interaction(s) with cognate tRNA(s)...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29155448/influence-of-national-centralization-of-oesophagogastric-cancer-on-management-and-clinical-outcome-from-emergency-upper-gastrointestinal-conditions
#5
S R Markar, H Mackenzie, T Wiggins, A Askari, A Karthikesalingam, O Faiz, S M Griffin, J D Birkmeyer, G B Hanna
BACKGROUND: In England in 2001 oesophagogastric cancer surgery was centralized. The aim of this study was to evaluate whether centralization of oesophagogastric cancer to high-volume centres has had an effect on mortality from different emergency upper gastrointestinal conditions. METHODS: The Hospital Episode Statistics database was used to identify patients admitted to hospitals in England (1997-2012). The influence of oesophagogastric high-volume cancer centre status (20 or more resections per year) on 30- and 90-day mortality from oesophageal perforation, paraoesophageal hernia and perforated peptic ulcer was analysed...
November 20, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/29155246/relatively-enriched-housing-conditions-delay-binge-onset-but-do-not-attenuate-binge-size
#6
Kerry E Preston, Rebecca L Corwin, Julia O Bader, Stephen L Crimmins
Housing and enrichment conditions are essential factors to consider when using animal models of behavior, as they can alter the behavior that is under investigation. The goal of this study was to determine the impact of the relatively enriched environment recommended by current animal care guidelines on development and maintenance of binge-type behavior in rats, using the limited access (LA) binge model. Non-food-deprived rats were divided into two groups, enriched and nonenriched, with all rats housed in shoebox cages...
November 15, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29154574/a-multivariate-dynamic-systems-model-for-psychotherapy-with-more-than-one-client
#7
Jonathan E Butner, Carlene Deits-Lebehn, Alexander O Crenshaw, Travis J Wiltshire, Nicholas S Perry, Robert G Kent de Grey, Jasara N Hogan, Timothy W Smith, Katherine J W Baucom, Brian R W Baucom
The dynamics of the give and take between therapist and client(s) is frequently of interest to therapy process researchers. Characterizing the ways that therapists respond to clients and clients respond to therapists can be challenging in therapeutic encounters involving a single therapist and a single client. The complexity of this challenge increases as the number of people involved in a therapeutic encounter increases not only because there are more people responding to one another but also because the patterns of responding can become more complex...
November 2017: Journal of Counseling Psychology
https://www.readbyqxmd.com/read/29154556/communal-motivation-and-well-being-in-interpersonal-relationships-an-integrative-review-and-meta-analysis
#8
Bonnie M Le, Emily A Impett, Edward P Lemay, Amy Muise, Konstantin O Tskhay
The motivation to care for the welfare of others, or communal motivation, is a crucial component of satisfying interpersonal relationships and personal well-being. The current meta-analysis synthesized 100 studies (Ntotal = 26,645) on communal motivation to establish its associations with subjective personal well-being (e.g., life satisfaction, positive affect, and negative affect) and relationship well-being (e.g., relationship satisfaction, partner-oriented positive affect, and partner-oriented negative affect) for both the person providing communal care and their partner...
November 20, 2017: Psychological Bulletin
https://www.readbyqxmd.com/read/29154448/significance-of-bizarre-cells-in-cervical-screening-liquid-based-cytology-a-prospective-study-of-15-cases
#9
O Ondič, R Ferko, J Kičinová, J Bouda, I Kinkorová-Luňáčková, L Kupcová, M Zůchová, J Chytra, T Waloschek, M Tůmová Bartošková, R Alaghehbandan, J Němcová
OBJECTIVE: The aim of this study was to assess the significance of bizarre cells (cells of squamous origin with a superficial squamous cell-type cytoplasm and characterised by multinucleation that produces bizarre nuclear shapes) in liquid-based cytology (LBC) Papanicoaou (pap) smears with clinical and histological follow-up correlation. METHODS: Fifteen patients, all with LBC samples containing bizarre cells, were identified in routine ThinPrep(®) LBC workload...
November 20, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29154277/potential-of-low-dose-leuco-methylthioninium-bis-hydromethanesulphonate-lmtm-monotherapy-for-treatment-of-mild-alzheimer-s-disease-cohort-analysis-as-modified-primary-outcome-in-a-phase-iii-clinical-trial
#10
Gordon K Wilcock, Serge Gauthier, Giovanni B Frisoni, Jianping Jia, Jiri H Hardlund, Hans J Moebius, Peter Bentham, Karin A Kook, Bjoern O Schelter, Damon J Wischik, Charles S Davis, Roger T Staff, Vesna Vuksanovic, Trevor Ahearn, Luc Bracoud, Kohkan Shamsi, Ken Marek, John Seibyl, Gernot Riedel, John M D Storey, Charles R Harrington, Claude M Wischik
BACKGROUND: LMTM is being developed as a treatment for AD based on inhibition of tau aggregation. OBJECTIVES: To examine the efficacy of LMTM as monotherapy in non-randomized cohort analyses as modified primary outcomes in an 18-month Phase III trial in mild AD. METHODS: Mild AD patients (n = 800) were randomly assigned to 100 mg twice a day or 4 mg twice a day. Prior to unblinding, the Statistical Analysis Plan was revised to compare the 100 mg twice a day as monotherapy subgroup (n = 79) versus 4 mg twice a day as randomized (n = 396), and 4 mg twice a day as monotherapy (n = 76) versus 4 mg twice a day as add-on therapy (n = 297), with strong control of family-wise type I error...
November 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29154251/long-term-effects-of-laryngeal-augmentation-with-calcium-hydroxyapatite-under-local-anaesthesia
#11
Ewelina Sielska-Badurek, Maria Sobol, Katarzyna Jędra, Anna Rzepakowska, Ewa Osuch-Wójcikiewicz, Kazimierz Niemczyk
Wstęp: Cel badania stanowi ocena efektów długoterminowych augmentacji krtani w znieczuleniu miejscowym przy pomocy hydroksyapatytu wapnia. Materiał i metody: W badaniu wzięło udział 17 pacjentów, którzy z powodu niewydolności szpary głośni (z powodu jednostronnego porażenia krtani oraz niewydolności mięśni wewnętrznych krtani) zostali zakwalifikowani do przeprowadzenia augmentacji krtani (10 kobiet i 17 mężczyzn), w wieku: 57,6±17,7 lat, mediana 61 lat, z zakresem: 32-83 lata. U wszystkich pacjentów wykonano augmentację krtani w znieczuleniu miejscowym, przez jamę ustną, podając bocznie od fałdu głosowego/ fałdów głosowych hydroksyapatyt wapnia (preparat Radiesse)...
October 31, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/29154161/effect-of-bovine-sperm-chromatin-integrity-evaluated-using-three-different-methods-on-in%C3%A2-vitro-fertility
#12
L S Castro, A F P Siqueira, T R S Hamilton, C M Mendes, J A Visintin, M E O A Assumpção
In vitro fertility potential of individual bulls is still relatively uncharacterized. Classical sperm analysis does not include the evaluation of all sperm characteristics and thus, some cell compartments could be neglected. In humans, sperm DNA integrity has already proven to have major influence in embryo development and assisted reproduction techniques successfully. In bovine, some studies already correlated chromatin integrity with field fertility. However, none of those have attempted to relate DNA assessment approaches such as chromatin deficiency (CMA3), chromatin stability (SCSA; AO+) and DNA fragmentation (COMET assay) to predict in vitro bull fertility...
November 10, 2017: Theriogenology
https://www.readbyqxmd.com/read/29154140/mouthpart-deformities-in-chironomidae-diptera-as-bioindicators-of-heavy-metals-pollution-in-shiroro-lake-niger-state-nigeria
#13
Francis O Arimoro, Yohanna I Auta, Oghenekaro N Odume, Unique N Keke, Adamu Z Mohammed
In this study, mouthpart deformities in Chironomid larvae (Diptera) were investigated in relation to sediment contamination in the Shiroro Lake in Nigeria. Metals and chironomids were sampled monthly at three stations (A-C) between August 2013 and January 2014. Across the stations, zinc ranged (3.9-75mg/g), manganese (1.29-1.65mg/g), lead (0.00-0.10mg/g), iron (101-168mg/g) and copper (0.13-0.17mg/g). The metal ions did not differ significantly (P > 0.05) between the sampling stations. However, zinc and iron ions were significantly different between the sampling seasons (P < 0...
November 16, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29153776/francisella-noatunensis-subspecies-noatunensis-clpb-deletion-mutant-impairs-development-of-francisellosis-in-a-zebrafish-model
#14
Elisabeth O Lampe, Carl Zingmark, Julia I Tandberg, Ida Marie P Thrane, Espen Brudal, Anders Sjöstedt, Hanne C Winther-Larsen
BACKGROUND: Francisella noatunensis ssp. noatunensis (F.n.n.) is the causative agent of francisellosis in Atlantic cod and constitutes one of the main challenges for future aquaculture on this species. A facultative intracellular bacterium like F.n.n. exert an immunologic challenge against which live attenuated vaccines in general are most effective. Thus, we constructed a deletion in the F.n.n. clpB gene as ΔclpB mutants are among the most promising vaccine candidates in human pathogenic Francisella...
November 16, 2017: Vaccine
https://www.readbyqxmd.com/read/29153551/remote-sensing-based-deforestation-analysis-in-mahanadi-and-brahmaputra-river-basin-in-india-since-1985
#15
M D Behera, P Tripathi, P Das, S K Srivastava, P S Roy, C Joshi, P R Behera, J Deka, P Kumar, M L Khan, O P Tripathi, T Dash, Y V N Krishnamurthy
Land use and land cover (LULC) change has been recognized as a key driver of global climate change by influencing land surface processes. Being in constant change, river basins are always subjected to LULC changes, especially decline in forest cover to give way for agricultural expansion, urbanization, industrialization etc. We used on-screen digital interpretation technique to derive LULC maps from Landsat images at three decadal intervals i.e., 1985, 1995 and 2005 of two major river basins of India. Rain-fed, Mahanadi river basin (MRB) attributed to 55% agricultural area wherein glacier-fed, Brahmaputra river basin (BRB) had only 16% area under agricultural land...
November 15, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29153485/morning-administration-of-0-4u-kg-day-insulin-glargine-300u-ml-provides-less-fluctuating-24-hour-pharmacodynamics-and-more-even-pharmacokinetic-profiles-compared-with-insulin-degludec-100u-ml-in-type-1-diabetes
#16
T S Bailey, J Pettus, R Roussel, W Schmider, M Maroccia, N Nassr, O Klein, G B Bolli, R Dahmen
AIM: To compare steady state pharmacodynamic and pharmacokinetic profiles of insulin glargine 300U/mL (Gla-300) with insulin degludec 100U/mL (Deg-100) in people with type 1 diabetes. METHODS: This single-centre, randomized, double-blind crossover euglycaemic clamp study included two parallel cohorts with fixed once-daily morning dose regimens. For both insulins participants received 0.4 (n=24) or 0.6U/kg/day (n=24), before breakfast, for 8 days prior to the clamp...
November 16, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29152977/local-disorder-and-tunable-luminescence-in-sr1-x-2al2-xsixo4-0-2-%C3%A2-x-%C3%A2-0-5-transparent-ceramics
#17
Alberto J Fernandez-Carrion, Kholoud Al Saghir, Emmanuel Veron, Ana I Becerro, Florence Porcher, Wolfgang Wisniewski, Guy Matzen, Franck Fayon, Mathieu Allix
Eu-doped Sr1-x/2Al2-xSixO4 (x = 0.2, 0.4, and 0.5) transparent ceramics have been synthesized by full and congruent crystallization from glasses prepared by aerodynamic levitation and laser-heating method. Structural refinements from synchrotron and neutron powder diffraction data show that the ceramics adopt a 1 × 1 × 2 superstructure compared to the SrAl2O4 hexagonal polymorph. While the observed superstructure reflections indicate a long-range ordering of the Sr vacancies in the structure, (29)Si and (27)Al solid-state NMR measurements associated with DFT computations reveal a significant degree of disorder in the fully polymerized tetrahedral network...
November 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29152863/using-an-acculturation-stress-resilience-framework-to-explore-latent-profiles-of-latina-o-language-brokers
#18
Jennifer A Kam, Katerina M Marcoulides, Andy J Merolla
With survey data from 243 Latina/o early adolescent language brokers, latent profile analyses were conducted to identify different types (i.e., profiles) of brokers. Profiles were based on how often Latina/o early adolescents brokered for family members, as well as their levels of family-based acculturation stress, negative brokering beliefs, parentification, and positive brokering beliefs. Three brokering profiles emerged: (1) infrequent-ambivalents, (2) occasional-moderates, and (3) parentified-endorsers...
December 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/29152376/crystal-structure-of-2-3-5-6-tetra-kis-pyridin-2-yl-pyrazine-hydrogen-peroxide-4-75-solvate
#19
Mger A Navasardyan, Stanislav I Bezzubov, Lyudmila G Kuz'mina, Petr V Prikhodchenko, Andrei V Churakov
The structure of the title co-crystal, C24H16N6·4.75H2O2, consists of a 2,3,5,6-tetra-kis-(pyridin-2-yl)pyrazine coformer and hydrogen peroxide solvent mol-ecules in an overall ratio of 1:4.75. Three of the six H2O2 mol-ecules modelled in the structure were found to be cross-orientationally disordered over two positions with occupancy ratios 0.846 (9):0.154 (9), 0.75 (2):0.25 (2), and 0.891 (9):0.109 (9). In the crystal, all of the peroxide mol-ecules are linked into hydrogen-bonded chains that propagate parallel to the a axis...
November 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29152373/a-two-dimensional-copper-i-coordination-polymer-based-on-1-2-cyclo-hexyl-sulfan-yl-eth-yl-pyridin-2-1h-one
#20
Hyunjin Park, Jineun Kim, Hansu Im, Tae Ho Kim
The reaction of copper(I) iodide with 1-[2-(cyclo-hexyl-sulfan-yl)eth-yl]pyridin-2(1H)-one (L, C13H19NOS) in aceto-nitrile/di-chloro-methane results in a crystalline coordination polymer, namely poly[bis-{μ2-1-[2-(cyclo-hexyl-sulfan-yl)eth-yl]pyridin-2(1H)-one}tetra-μ3-iodido-tetra-copper(I)], [Cu4I4L2] n . The asymmetric unit comprises two ligand mol-ecules, four copper(I) ions and four iodide ions. Inter-estingly, the O atoms are bound to the soft copper(I) ions. The stair-step clusters of Cu and I atoms in the asymmetric unit are linked repeatedly, giving rise to infinite chains along [100]...
November 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
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