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Hyperplasia prostatic benign

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https://www.readbyqxmd.com/read/29775699/relationship-between-intraprostatic-urethral-sphincter-status-and-prostate-volume-as-revealed-by-magnetic-resonance-imaging
#1
Fumiyasu Endo, Kazuhiro Ohwaki, Masaki Shimbo, Kazunori Hattori
OBJECTIVES: To evaluate the relationship between the lengths of two regions of the intraprostatic urethral sphincter, the distal region (from the apex to the adenoma; AA) and the proximal region (from the adenoma to the verumontanum; AV) and prostate volume (PV) in patients with clinical benign prostate hyperplasia. METHODS: A total of 110 patients who underwent magnetic resonance imaging (MRI) prior to holmium laser enucleation of the prostate were enrolled. The lengths of two distinct intraprostatic urethral regions were measured on MRI, and we used multiple regression analysis to explore the association between these lengths and PV...
May 15, 2018: Urology
https://www.readbyqxmd.com/read/29775639/surgical-management-of-lower-urinary-tract-symptoms-attributed-to-benign-prostatic-hyperplasia-aua-guideline
#2
Harris E Foster, Michael J Barry, Philipp Dahm, Manhar C Gandhi, Steven A Kaplan, Tobias S Kohler, Lori B Lerner, Deborah J Lightner, J Kellogg Parsons, Claus G Roehrborn, Charles Welliver, Timothy J Wilt, Kevin T McVary
Purpose; Male lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH) is common in men and can have negative effects on quality of life (QOL). It is the hope that this Guideline becomes a reference on the effective evidence-based surgical management of LUTS/BPH. MATERIALS/METHODS: The evidence team searched Ovid MEDLINE, the Cochrane Library, and the Agency for Healthcare Research and Quality (AHRQ) database to identify studies indexed between January 2007 and September 2017...
May 15, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29774812/robot-assisted-simple-prostatectomy-by-an-extraperitoneal-approach
#3
Jens-Uwe Stolzenburg, Panagiotis Kallidonis, Iason Kyriazis, Dimitrios Kotsiris, Panteleimon Ntasiotis, Evangelos N Liatsikos
The incidence of symptomatic benign prostate hyperplasia and bladder outlet obstruction has increased during the last two decades. Most of men are treated conservatively. When medical therapy is inadequate to relief symptoms, surgical treatment is necessary. Absolute indications for surgical treatment are gross hematuria, recurrent urinary infections and retentions as well as bladder stones. With advent of minimally invasive surgery, large prostates tend to be treated either endoscopically or laparoscopically (including robotic assistance)...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29774590/heritage-of-stanislaw-ciechanowski-1869-1945-discoverer-of-pathogenesis-of-prostatic-hyperplasia-passionis-insignia-signis-fulgent-mirificis
#4
Andrzej Wincewicz, Piotr Woltanowski, Stanisław Sulkowski
BACKGROUND: Prostatic enlargement was first correctly recognized as a prostatic hyperplasia by professor of anatomic pathology, Stanisław Ciechanowski (1869-1945) in Cracow on contrary to Parisian urologist Jean Casimir Félix Guyon's concepts of progressing atherosclerosis as a morphological cause of prostatic overgrowth and mechanical insufficiency of lower urinary tract. METHODS: Primary resources were analyzed about Stanisław Ciechanowski mainly from depositories of the Section of Special Collection, Stanisław Konopka Main Medical Library Warsaw and Polish bibliograhy of Estreichers at Jagiellonian University...
May 18, 2018: Prostate
https://www.readbyqxmd.com/read/29772622/-delay-in-high-grade-metastatic-prostate-cancer-progression-by-dutasteride-a-case-report
#5
Yuya Yamada, Hiroshi Fujiwara, Shinya Somiya, Shohei Fujikawa, Yuki Kamiyama, Masahiro Tamaki, Toshio Kanaoka
An 84-year-old man was referred to our hospital with swollen right cervical lymph nodes. Computed tomography showed right supraclavicular and mediastinal lymph node enlargement, and fluorodeoxyglucose positronemissiontomography showed multiple areas of abnormally increased radioactivity inthe right supraclavicular and mediastinal lymph nodes, right ninth rib, and left fifth and seventh ribs. Biopsy of the right supraclavicular lymph node revealed metastatic adenocarcinoma with partial immunohistochemical staining for prostate specific antigen (PSA)...
April 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29770312/state-of-the-art-of-prostatic-arterial-embolization-for-benign-prostatic-hyperplasia
#6
REVIEW
Mario Petrillo, Filippo Pesapane, Enrico Maria Fumarola, Ilaria Emili, Marzia Acquasanta, Francesca Patella, Salvatore Alessio Angileri, Umberto G Rossi, Igor Piacentini, Antonio Maria Granata, Anna Maria Ierardi, Gianpaolo Carrafiello
Prostatectomy via open surgery or transurethral resection of the prostate (TURP) is the standard treatment for benign prostatic hyperplasia (BPH). Several patients present contraindication for standard approach, individuals older than 60 years with urinary tract infection, strictures, post-operative pain, incontinence or urinary retention, sexual dysfunction, and blood loss are not good candidates for surgery. Prostatic artery embolization (PAE) is emerging as a viable method for patients unsuitable for surgery...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29767479/nocturia-is-more-bothersome-than-daytime-luts-results-from-an-observational-real-life-practice-database-including-8659-european-and-american-luts-patients
#7
Karel Everaert, Peter Anderson, Robert Wood, Fredrik L Andersson, Tove Holm-Larsen
PURPOSE: Lower urinary tract symptoms (LUTS) encompass several diagnoses, including overactive bladder (OAB) and benign prostatic hyperplasia (BPH). Nocturia is a standalone symptom, but also included in OAB and BPH. Current discussion addresses whether the overlap of the diagnoses is too broad, leading to misdiagnosis. This study explored the differences in level, causes and consequences for patients with a diagnosis of daytime LUTS compared with a diagnosis of nocturia, and discussed whether people are being treated for the symptoms that truly bother them the most...
May 16, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29760869/metabolic-alterations-in-urine-extracellular-vesicles-are-associated-to-prostate-cancer-pathogenesis-and-progression
#8
Marc Clos-Garcia, Ana Loizaga-Iriarte, Patricia Zuñiga-Garcia, Pilar Sánchez-Mosquera, Ana Rosa Cortazar, Esperanza González, Verónica Torrano, Cristina Alonso, Miriam Pérez-Cormenzana, Aitziber Ugalde-Olano, Isabel Lacasa-Viscasillas, Azucena Castro, Felix Royo, Miguel Unda, Arkaitz Carracedo, Juan M Falcón-Pérez
Urine contains extracellular vesicles (EVs) that concentrate molecules and protect them from degradation. Thus, isolation and characterisation of urinary EVs could increase the efficiency of biomarker discovery. We have previously identified proteins and RNAs with differential abundance in urinary EVs from prostate cancer (PCa) patients compared to benign prostate hyperplasia (BPH). Here, we focused on the analysis of the metabolites contained in urinary EVs collected from patients with PCa and BPH. Targeted metabolomics analysis of EVs was performed by ultra-high-performance liquid chromatography-mass spectrometry...
2018: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/29760826/best-prophylactic-strategy-in-groups-at-risk-of-intraoperative-floppy-iris-syndrome-development-comparison-between-atropine-instillation-and-adrenaline-intracameral-injection
#9
Raffaele Nuzzi, Paolo Arnoffi, Federico Tridico
Background: Intraoperative Floppy Iris Syndrome (IFIS) is an important cause of surgical complications and iris defects in patients undergoing phacoemulsification that were treated with selective subtype α1A receptor antagonists for a long period of time. To date, no definitive preventive strategy has emerged, yet. The need of prophylaxis is dictated by the high prevalence of males affected by benign prostatic hyperplasia undergoing cataract surgery. Objective: To identify the best prophylactic strategy in groups at risk of IFIS development by comparing two mydriatic treatments in course of phacoemulsification surgery...
2018: Open Ophthalmology Journal
https://www.readbyqxmd.com/read/29756415/the-expression-of-androgen-receptor-and-its-variants-in-human-prostate-cancer-tissue-according-to-disease-status-and-its-prognostic-significance
#10
Sung Woo Park, Jung Hee Kim, Hyun Jung Lee, Dong Hoon Shin, Sang Don Lee, Sik Yoon
PURPOSE: To evaluate changes in the expression of androgen receptor (AR) and its variants (ARVs) in human prostate cancer (PCa) tissues according to disease status, and its prognostic significance following radical prostatectomy (RP). MATERIALS AND METHODS: A total of 282 PCa cases were evaluated, which included 252 localized PCa, 8 metastatic castration resistant prostate cancer (CRPC), and 22 benign prostatic hyperplasia (BPH) cases. Samples were collected from patients who underwent RP or transurethral resection and were stored in ethically approved tissue banks...
April 16, 2018: World Journal of Men's Health
https://www.readbyqxmd.com/read/29752646/mri-features-after-prostatic-artery-embolization-for-the-treatment-of-medium-and-large-volume-benign-hyperplasia
#11
Hongtao Zhang, Yanguang Shen, Jingjing Pan, Haiyi Wang, Yan Zhong, Yingwei Wang, Huiyi Ye
PURPOSE: To assess magnetic resonance imaging (MRI) features after prostatic artery embolization (PAE) for the treatment of medium- and large-volume benign prostatic hyperplasia and to correlate prostate volume with clinical indexes. METHODS: We retrospectively evaluated 28 patients who underwent PAE. MRI examinations of the prostate were performed to evaluate signal intensity changes and the characteristics of infarcted areas. Prostate volume and the apparent diffusion coefficient (ADC) were measured at an average of 10 days post-PAE and at 1, 3, 6, and 12 months post-PAE...
May 12, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29751756/prevalence-of-asthma-among-the-adult-general-population-of-five-middle-eastern-countries-results-of-the-snapshot-program
#12
Hesham Tarraf, Omur Aydin, Dilsad Mungan, Mohammad Albader, Bassam Mahboub, Adam Doble, Aaicha Lahlou, Luqman Tariq, Fayaz Aziz, Abdelkader El Hasnaoui
BACKGROUND: Asthma is a common chronic respiratory disease leading to morbidity, mortality and impaired quality of life worldwide. Information on asthma prevalence in the Middle East is fragmented and relatively out-dated. The SNAPSHOT program was conducted to obtain updated information. METHODS: SNAPSHOT is a cross-sectional epidemiological program carried out in five Middle Eastern countries (Egypt, Turkey, Kuwait, Saudi Arabia, and the United Arab Emirates, the latter three grouped into a Gulf cluster) to collect data on asthma, allergic rhinitis, benign prostatic hyperplasia and bipolar disorder...
May 11, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29749775/the-use-of-tiemann-tip-catheters-for-male-intermittent-self-catheterisation
#13
Maggie Rew, Helen Lake, Kayleigh Brownlee-Moore
Male catheterisation can be difficult to perform, especially in patients with an enlarged prostate gland or other potentially obstructive conditions in the lower urinary tract. Repeated and unsuccessful catheterisations, as well as causing trauma, pain and distress, can cause other conditions such as urethral strictures and 'false passages' (when the catheter is pushed through the urethral wall instead of passing down the urethra), which then require more costly interventions to correct. With an increasingly ageing population these complications are expected to rise, putting added strain on an already stretched health service...
May 10, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29749520/silencing-of-urg11-expression-inhibits-the-proliferation-and-epithelial%C3%A2-mesenchymal-transition-in-benign-prostatic-hyperplasia-cells-via-the-rhoa-rock1-pathway
#14
Guanying Zhang, Feng Zhu, Guangye Han, Zeyu Li, Quanfeng Yu, Zhenhui Li, Jianchang Li
Upregulated gene 11 (URG11) represents a gene upregulated by hepatitis B virus X protein and is involved in the biological processes of multifarious tumors. The present study aimed to investigate the protective effects and regulatory mechanisms of URG11 in benign prostatic hyperplasia (BPH). URG11, Ras homolog family member A (RhoA) and Rho‑associated protein kinase 1 (ROCK1) expression was detected in patients with BPH using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). Furthermore, URG11 expression was silenced using URG11‑targeting small interfering RNAs...
May 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29749458/%C3%AE-klotho-inhibits-androgen-androgen-receptor%C3%A2-associated-epithelial%C3%A2-mesenchymal-transition-in-prostate-cancer-through-inactivation-of-erk1-2-signaling
#15
Zhao Liu, Hui Zhang, Sentai Ding, Shasha Qi, Shuai Liu, Dingqi Sun, Wei Dong, Lei Yin, Mingjiang Li, Xingbo Zhao, Jiaju Lu
The epithelial‑mesenchymal transition (EMT) is reported to have intimate crosstalk with androgen receptor (AR) signaling in prostate cancer (PCa) and is known to be responsible for castration resistance. Fibroblast growth factor/receptor (FGF/FGFR) signaling is also involved in tumor progression and EMT in multiple tissues. Several studies have investigated the role of βKlotho, an FGF/FGFR signaling co‑receptor in tumorigenesis. However, its role in PCa remains unknown. In the present study, the role of androgen in the EMT of PCa cells was examined by western blotting...
April 25, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29745091/upregulation-of-mir-191-promotes-cell-growth-and-invasion-via-targeting-timp3-in-prostate-cancer
#16
Xueling Wang, Zhimin Shi, Xiaoxia Liu, Ying Su, Weixia Li, Haiping Dong, Liwei Zhao, Manman Li, Yunxiao Wang, Xiu Jin, Zhongchao Huo
PURPOSE: Prostate cancer (PCa) is the most frequently malignant neoplasm in men. MicroRNAs (miRs) have been identified to play important biological roles in a variety of tumors. Several studies showed that miR-191 was involved in the development of different cancers, but its role in prostate cancer remains unclear. METHODS: Human PCa cell lines DU145, PC-3 and LNCAP, and benign prostate hyperplasia (BPH) and human prostate epithelial cell line RWPE-1 were used. The expression level of miR-191 in 48 paired prostate tumor and adjacent normal tissues was assessed along with the clinical patient features...
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29741162/the-urinary-sarcosine-creatinine-ratio-is-a-potential-diagnostic-and-prognostic-marker-in-prostate-cancer
#17
Meng Wang, Lihui Zou, Jing Liang, Xin Wang, Dalei Zhang, Yuan Fang, Junhua Zhang, Fei Xiao, Ming Liu
BACKGROUND The aim of this study was to evaluate the role of the urinary sarcosine/creatinine ratio in the diagnosis and prognosis of prostate cancer, using a sarcosine oxidase assay. MATERIAL AND METHODS Urine samples were obtained from 203 patients with benign prostate hyperplasia (BPH) and 209 patients with prostate cancer. Levels of urinary sarcosine were measured using the sarcosine oxidase method. The urinary sarcosine/creatinine ratios were compared between the group of patients with BPH and the patients with prostate cancer...
May 9, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29741118/15-years-survey-of-safety-and-efficacy-of-serenoa-repens-extract-in-benign-prostatic-hyperplasia-patients-with-risk-of-progression
#18
Andrey Zinovievich Vinarov, Leonid Grigorievich Spivak, Darina Vladimirovna Platonova, Leonid Mikhailovich Rapoport, Dmitry Olegovich Korolev
AIM: The aim of this study is to investigate the efficacy and safety of long-term therapy with Serenoa repens extract with regard to halting benign prostatic hyperplasia progression. MATERIAL AND METHODS: An open non-comparative observational study of the continuous use of S. repens plant extract at a dosage of 320 mg once a day for 15 years was performed in 30 patients at risk for benign prostatic hyperplasia progression. Changes in IPSS (International Prostatic Symptoms Scale) and QoL (Quality of life) scores and changes in Qmax, voided volume, residual urine volume, and prostate volume were evaluated during the study...
May 1, 2018: Urologia
https://www.readbyqxmd.com/read/29740534/genomic-dna-methylation-derived-algorithm-enables-accurate-detection-of-malignant-prostate-tissues
#19
Erfan Aref-Eshghi, Laila C Schenkel, Peter Ainsworth, Hanxin Lin, David I Rodenhiser, Jean-Claude Cutz, Bekim Sadikovic
Introduction: The current methodology involving diagnosis of prostate cancer (PCa) relies on the pathology examination of prostate needle biopsies, a method with high false negative rates partly due to temporospatial, molecular, and morphological heterogeneity of prostate adenocarcinoma. It is postulated that molecular markers have a potential to assign diagnosis to a considerable portion of undetected prostate tumors. This study examines the genome-wide DNA methylation changes in PCa in search of genomic markers for the development of a diagnostic algorithm for PCa screening...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29738187/-influence-of-photoselective-vaporization-of-the-prostate-on-the-sexual-function-of-the-patient
#20
REVIEW
Hua-Jie Zhang, Guo-Sheng Yang
n recent years, photoselective vaporization of the prostate (PVP) has gained a wide clinical application in the treatment of benign prostatic hyperplasia (BPH) for its satisfactory effect, high safety, and low incidence of complications. With the improvement of living conditions, BPH patients are paying more attention to their sexual function, especially erectile function and ejaculatory problems instead of just focusing on the alleviation of lower urinary tract symptoms. Few studies of PVP, however, relate to its association with the sexual function of the patient and there is a certain controversy over the influence of PVP on it in the existing literature...
December 2017: Zhonghua Nan Ke Xue, National Journal of Andrology
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