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https://www.readbyqxmd.com/read/29793176/non-ldl-dyslipidemia-is-prevalent-in-the-young-and-determined-by-lifestyle-factors-and-age-the-lifelines-cohort
#1
Jeroen K de Vries, Jan W Balder, Michelle J Pena, Petra Denig, Andries J Smit
BACKGROUND AND AIMS: Non-LDL dyslipidemia (NLD) confers cardiovascular risk, and prevalence rates appear to be high in elderly populations. Small cohorts have identified several lifestyle, anthropometric, and medical factors associated with NLD. We aimed to assess sex- and age-specific prevalence of NLD in a contemporary population cohort (n = 167 729), and to identify independent determinants of NLD, focusing on lifestyle, anthropometric, and medical factors. METHODS: The prevalence of NLD was assessed per 10-year age intervals in adults without cardiovascular disease not using lipid-modifying drugs from the Dutch LifeLines cohort...
May 21, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29790373/non-clinical-studies-of-progesterone
#2
R Sitruk-Ware
Progesterone is a steroid hormone that is essential for the regulation of reproductive function. Progesterone has been approved for several indications including the treatment of anovulatory menstrual cycles, assisted reproductive technology, contraception during lactation and, when combined with estrogen, for the prevention of endometrial hyperplasia in postmenopausal hormonal therapy. In addition to its role in reproduction, progesterone regulates a number of biologically distinct processes in other tissues, particularly in the nervous system...
May 23, 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29786828/oral-contraceptives-for-pain-associated-with-endometriosis
#3
REVIEW
Julie Brown, Tineke J Crawford, Shree Datta, Andrew Prentice
BACKGROUND: Endometriosis is a common gynaecological condition which affects many women of reproductive age worldwide and is a major cause of pain and infertility. The combined oral contraceptive pill (COCP) is widely used to treat pain occurring as a result of endometriosis, although the evidence for its efficacy is limited. OBJECTIVES: To determine the effectiveness, safety and cost-effectiveness of oral contraceptive preparations in the treatment of painful symptoms ascribed to the diagnosis of laparoscopically proven endometriosis...
May 22, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29785760/thyroid-function-in-hidradenitis-suppurativa-a-population-based-cross-sectional-study-from-denmark
#4
I M Miller, G Vinding, H A Sørensen, H Rytgaard, U B Mogensen, C Ellervik, G B Jemec
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory disease. Numerous studies have associated HS with obesity, and recently with metabolic syndrome (MetS). Both obesity and MetS are linked with metabolic changes. Thyroid hormones play a central role in metabolism and exert pleiotropic effects on adipogenesis and the basal metabolism of lipids and glucose. We hypothesized that patients with HS have an altered or dysfunctional metabolism expressed as thyroid function. AIM: To investigate thyroid function in individuals with HS compared with healthy controls (HCs)...
May 21, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29782306/urticarial-lesions-in-a-pregnant-woman
#5
Sergio Santos-Alarcón, Cesar Benavente-Villegas, Isabel García-Briz, Magdalena Moneva-Léniz, Celia Sanchis-Sánchez, Almudena Mateu-Puchades
Dear Editor, Gestational pemphigoid (GP) is a rare autoimmune bullous dermatosis in pregnancy. GP usually occurs during the second or third month of pregnancy. It clinically manifests as the development of either early-onset urticarial lesions or late-onset subepidermal blisters that may linger for weeks or even months. Herein we report the case of a 45-year-old woman with the distinctive clinical onset of GP. A forty-five-year-old woman, gravida I, para 0, at 27 weeks gestation, was referred for evaluation to our Department with an extensive pruritic eruption that had developed over the previous 7 days...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29782195/acute-pancreatitis-secondary-to-oral-contraceptive-induced-hypertriglyceridemia-a-case-report
#6
Matheo Augusto Morandi Stumpf, Ana Claudia Garabeli Cavalli Kluthcovsky, Jefferson Matsuiti Okamoto, Gianna Carla Alberti Schrut, Patricia de Oliveira Cajoeiro, Ana Paula Marte Chacra, Ricardo Bizeli
Hypertriglyceridemia is the third most common cause of acute pancreatitis. Among the causes that lead to secondary hypertriglyceridemia, the use of contraceptive agents is the main reason to be assessed in young women. We report a case of a 31-year-old woman who had suffered two acute pancreatitis episodes secondary to hypertriglyceridemia. In the investigation, the previous medical team indicated a genetic screening before ruling out all secondary causes. LPL, apo CII and apo AV genes were negative for mutations...
May 21, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29769824/immune-response-in-women-during-exercise-in-the-heat-a-spotlight-on-oral-contraception
#7
Brianna Larsen, Amanda J Cox, Karlee Quinn, Rhiannon Fisher, Clare Minahan
This study compared the immune and stress response of oral contraceptive users (WomenOC; n = 9) to normally-menstruating women (WomenNM; n = 9) at rest and during exercise in temperate (TEMP; 22°C) and hot (HEAT; 35°C) conditions. Participants performed a 3-stage cycling trial in each condition at 90% (Stage 1; 30 min), 135% (Stage 2; 15 min), and 180% (Stage 3; 7.5 min) of lactate threshold 1. C-reactive protein (CRP) and immune cell counts were measured at rest, and serum cytokines (IL-1β, IL-1RA, IL-6, IL-8, IL-10, and TNF-α) and salivary cortisol were evaluated before and after exercise in both the TEMP and HEAT conditions...
June 2018: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/29768947/linking-back-to-back-stimulation-cycles-with-oral-contraceptives-or-progestins-in-women-undergoing-embryo-accumulation-for-preimplantation-genetic-testing-a-retrospective-study
#8
Jorge Rodriguez-Purata, Marta Devesa, Mónica Parriego, Clara Pardos, Ignacio Rodriguez, Nikolaos P Polyzos, Francisca Martínez, Buenaventura Coroleu
This retrospective study was carried out to determine which strategy is associated with improved outcomes in two back-to-back cycles when undergoing embryo accumulation. Eighty patients with two stimulation cycles performed with <45 days between retrievals between Jan'16-Mar'17 were included. Patients were segregated according to the strategy used to link stimulations: spontaneous menses (SM), vaginal micronized progesterone (VMP) or oral contraceptive pills (OCP). Main outcome measure was oocytes retrieved...
May 17, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29768114/differences-in-contraceptive-discontinuation-among-black-and-white-women-evidence-from-the-contraceptive-choice-project
#9
Jenifer E Allsworth, Gina M Secura, Olufemi O Ajibade, Jeffrey F Peipert
OBJECTIVE: We sought to evaluate whether differences in rates of contraceptive discontinuation exist among black and white women receiving contraceptive counseling and no-cost contraception among users of long-acting reversible contraceptive (LARC; intrauterine devices or subdermal implant) and non-LARC (oral contraceptive pills, contraceptive vaginal ring, patch, or injection) methods. MATERIALS AND METHODS: We analyzed data from a prospective cohort study of 7546 non-Hispanic black and white women who participated in the Contraceptive CHOICE Project...
May 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29766610/sensitive-and-simultaneous-quantitation-of-6%C3%AE-hydroxycortisol-and-cortisol-in-human-plasma-by-lc-ms-ms-coupled-with-stable-isotope-dilution-method
#10
Ryohei Hirano, Akitomo Yokokawa, Takashi Furuta, Hiromi Shibasaki
CYP3A phenotyping provide a means for personalized drug therapy. We focused our attention on the plasma 6β-hydroxycortisol (6β-OHF) to cortisol ratio as an index for CYP3A phenotyping. In the present study, we developed a sensitive and reliable method for the simultaneous determination of 6β-OHF and cortisol in human plasma using high-performance liquid chromatography/tandem mass spectrometry (LC-MS/MS) together with picolinylester derivatization or nonderivatization methods and 6β-[9,11,12,12-2 H4 ]hydroxycortisol and [1,2,4,19-13 C4 ]cortisol as internal standards for in vivo CYP3A phenotyping in humans...
May 15, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29745237/association-between-progestin-only-contraceptive-use-and-cardiometabolic-outcomes-a-systematic-review-and-meta-analysis
#11
Marija Glisic, Sara Shahzad, Stergiani Tsoli, Mahmuda Chadni, Eralda Asllanaj, Lyda Z Rojas, Elizabeth Brown, Rajiv Chowdhury, Taulant Muka, Oscar H Franco
Aims The association between progestin-only contraceptive (POC) use and the risk of various cardiometabolic outcomes has rarely been studied. We performed a systematic review and meta-analysis to determine the impact of POC use on cardiometabolic outcomes including venous thromboembolism, myocardial infarction, stroke, hypertension and diabetes. Methods and results Nineteen observational studies (seven cohort and 12 case-control) were included in this systematic review. Of those, nine studies reported the risk of venous thromboembolism, six reported the risk of myocardial infarction, six reported the risk of stroke, three reported the risk of hypertension and two studies reported the risk of developing diabetes with POC use...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29742655/gabapentin-for-the-treatment-of-vulvodynia-a-randomized-controlled-trial
#12
Candace S Brown, Gloria A Bachmann, Jim Wan, David C Foster
OBJECTIVE: To evaluate whether extended-release gabapentin is more effective than placebo among women with vulvodynia. METHODS: In a multicenter double-blind, placebo-controlled randomized crossover trial, gabapentin (1,200-3,000 mg/d) was compared with a placebo. The primary outcome was mean pain intensity (0, no pain at all to 10, worst pain ever) on the tampon test (a standardized tampon insertion and removal test used as a surrogate marker for dyspareunia) during the last 7 days of the maintenance phase...
May 7, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29741787/gonadal-hormones-modulate-the-hpa-axis-and-the-sns-in-response-to-psychosocial-stress
#13
Efrat Barel, Randa Abu-Shkara, Raul Colodner, Refaat Masalha, Lila Mahagna, Or Chen Zemel, Ami Cohen
Exposure to stress activates both the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS). A growing body of research points to the contribution of sex hormones (testosterone, estrogen, and progesterone), the end products of the hypothalamus-pituitary-gonadal (HPG) axis, in modulating stress reactivity. The present study aimed at investigating the potential modulating role of sex hormones on HPA and SNS reactivity to psychosocial stress. The reactivity, induced by the Trier Social Stress Test, was analyzed by measuring the levels of cortisol and alpha-amylase (markers for SNS activity) in four saliva samples each of 21 men and 37 women (17 not using oral contraceptives and in their luteal phase, and 20 women using oral contraceptives)...
May 9, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29739429/women-s-attitudes-and-beliefs-towards-specific-contraceptive-methods-in-bangladesh-and-kenya
#14
Kazuyo Machiyama, Fauzia Akhter Huda, Faisal Ahmmed, George Odwe, Francis Obare, Joyce N Mumah, Marylene Wamukoya, John B Casterline, John Cleland
BACKGROUND: Missing from the huge literature on women's attitudes and beliefs concerning specific contraceptive methods is any detailed quantitative documentation for all major methods in low- and middle-income countries. The objectives are to provide such a documentation for women living in Matlab (rural Bangladesh), Nairobi slums and Homa Bay (rural Kenya) and to compare the opinions and beliefs of current, past and never users towards the three most commonly used methods (oral contraceptives, injectables and implants)...
May 8, 2018: Reproductive Health
https://www.readbyqxmd.com/read/29737900/effects-of-age-gender-and-menstrual-cycle-on-platelet-function-assessed-by-impedance-aggregometry
#15
G Berlin, M Hammar, L Tapper, N Tynngård
Platelets are needed to prevent or arrest bleeding and aggregate at the site of injury upon vascular damage. Platelets express receptors for estrogens which might affect the function of the platelets and their hemostatic ability. The aim was to identify possible differences in platelet function related to age, gender, and phases of the menstrual cycle by use of impedance aggregometry with Multiplate. In the first part of the study, platelet function was assessed in 60 healthy individuals (30 men and 30 women) in each of three age groups (20-25, 40-45, and 60-65 years)...
May 8, 2018: Platelets
https://www.readbyqxmd.com/read/29732937/factors-of-the-epidemiological-triad-that-influence-the-persistence-of-human-papilloma-virus-infection-in-women-with-systemic-lupus-erythematosus
#16
S Méndez-Martínez, M García-Carrasco, E A Jiménez-Herrera, C Mendoza-Pinto, I Etchegaray-Morales, P W Barahona-Rubio, J L Gálvez-Romero, P Munguía-Realpozo, C O Muñóz-Guarneros, M L Cedillo-Ramírez, S E Silva-Gómez, G Linares-Fleites, A Rojas-Vallaraga
We studied the epidemiologic triad-related factors influencing human papilloma virus (HPV) persistence in Mexican women with systemic lupus erythematosus (SLE). Patients aged ≥18 years with SLE (American College of Rheumatology criteria), with and without HPV persistence, were selected. Groups were analyzed by (1) host: clinical disease characteristics; (2) agent: (I) infectious (prevalence, incidence, HPV genotype and co-infections (≥2 HPV genotypes or mycoplasmas)), (II) chemical (contraceptives and immunosuppressive drugs) and (III) physical (vitamin D deficiency) and (3) environment...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29727219/brachial-artery-endothelial-function-is-stable-across-a-menstrual-and-oral-contraceptive-pill-cycle-but-lower-in-premenopausal-women-than-age-matched-men
#17
Ninette Shenouda, Stacey E Priest, Vanessa I Rizzuto, Maureen J MacDonald
Sex hormone concentrations differ between men, premenopausal women with natural menstrual cycles (NAT), and premenopausal women using oral contraceptive pills (OCP), as well as across menstrual or OCP phases. This study sought to investigate how differences in sex hormones, particularly estradiol, between men and women and across cycle phases, may influence brachial artery endothelial function. Fifty-three healthy adults (22{plus minus}3 yrs; 20 men, 15 NAT, 18 second, third or fourth generation OCP) underwent assessments of sex hormones and endothelial (flow-mediated dilation test, FMD) and smooth muscle (nitroglycerin test, NTG) function...
May 4, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29725277/use-of-oral-contraceptives-for-management-of-acne-vulgaris-and-hirsutism-in-women-of-reproductive-and-late-reproductive-age
#18
Radosław Słopień, Ewa Milewska, Piotr Rynio, Błażej Męczekalski
Hormonal contraception in both reproductive and late reproductive age, as well as contraceptive action, is used also for other indications like dysmenorrhoea, menstrual disorders, endometriosis, acne vulgaris, and hirsutism. Acne vulgaris and hirsutism are important signs related to hyperandrogenaemia and present a serious medical problem for the patients and a challenge for medical doctors in terms of effective treatment. The application of hormonal contraception to treat acne vulgaris and hirsutism requires knowledge of the mechanism of antiandrogenic actions and the possible contraindications and complications...
March 2018: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/29723658/common-risk-factors-of-dry-socket-alveolitis-osteitis-following-dental-extraction-a-brief-narrative-review
#19
Vahid Rakhshan
Dry socket is a common complication of dental extraction, especially extraction of third molars. Knowledge of the frequent risk factors of alveolitis osteitis is useful in determining high-risk patients, treatment planning, and preparing the patients mentally. The aim of this narrative review was to summarize the common risk factors of dry socket. A bibliographic search was carried out to find literature regarding risk factors of dry socket after tooth extraction. Each full article or abstract was read at least twice, and the relevant information was summarized...
April 30, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29720882/drospirenone-containing-oral-contraceptives-and-venous-thromboembolism-an-analysis-of-the-faers-database
#20
David Madigan, Jennifer Shin
Introduction: Substantial evidence suggests that drospirenone-containing oral contraceptives may cause a higher risk of venous thrombotic events than earlier-generation oral contraceptives. Methods: To gain insight into recent real-world implications, we conducted an analysis using the US Food and Drug Administration's Adverse Event Reporting System. Results: Venous thrombotic events continue to be reported at a much higher rate with drospirenone-containing oral contraceptives than the general background...
2018: Open Access Journal of Contraception
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