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https://www.readbyqxmd.com/read/28930603/centchroman-a-safe-reversible-postcoital-contraceptive-with-curative-and-prophylactic-activity-in-many-disorders
#1
Ved P Kamboj, Suprabhat Ray, Nitya Anand
Centchroman (INN: Ormeloxifene), a reversible post-coital/weekly oral contraceptive (half-life of about 168 hours), designed and developed at CDRI, Lucknow is the only non-steroidal oral contraceptive in clinical use in the world today. Synthesized in 1967 and completing pre-clinical and clinical studies in 1989, this drug was approved for marketing in 1991, social marketing in 1995 and NFPW in April 2016. It acts by preventing implantation of blastocyst in endometrium. It is the only contraceptive which neither suppresses ovulation nor interferes with the hypothalamic-pituitary-ovarian axis...
January 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28930233/dietary-isoflavones-and-breast-cancer-risk
#2
REVIEW
Samira Ziaei, Reginald Halaby
Breast cancer is the deadliest neoplasm in women globally, resulting in a significant health burden. In many cases, breast cancer becomes resistant to chemotherapy, radiation, and hormonal therapies. It is believed that genetics is not the major cause of breast cancer. Other contributing risk factors include age at first childbirth, age at menarche, age at menopause, use of oral contraceptives, race and ethnicity, and diet. Diet has been shown to influence breast cancer incidence, recurrence, and prognosis...
April 7, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28929625/association-of-trauma-and-posttraumatic-stress-disorder-with-incident-systemic-lupus-erythematosus-sle-in-a-longitudinal-cohort-of-women
#3
Andrea L Roberts, Susan Malspeis, Laura D Kubzansky, Candace H Feldman, Shun-Chiao Chang, Karestan C Koenen, Karen H Costenbader
OBJECTIVE: To conduct the first longitudinal study examining whether trauma exposure and PTSD are associated with increased risk of incident SLE in a civilian cohort. METHODS: We examined the association of trauma exposure and PTSD symptoms with SLE incidence over 24 years of follow-up in a U.S. longitudinal cohort of women (N=54,763). Incident SLE with ≥4 American College of Rheumatology criteria was ascertained by self-report and confirmed by medical record review...
September 20, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28929349/depression-and-anxiety-in-polycystic-ovary-syndrome-etiology-and-treatment
#4
REVIEW
Laura G Cooney, Anuja Dokras
PURPOSE OF REVIEW: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive age women and is associated with an increased prevalence of depression and anxiety symptoms. This review presents potential mechanisms for this increased risk and outlines treatment options. RECENT FINDINGS: Women with PCOS have increased odds of depressive symptoms (OR 3.78; 95% CI 3.03-4.72) and anxiety symptoms (OR 5.62; 95% CI 3.22-9.80). Obesity, insulin resistance, and elevated androgens may partly contribute to this association...
September 20, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28927899/does-hormonal-contraception-during-molar-pregnancy-follow-up-influence-the-risk-and-clinical-aggressiveness-of-gestational-trophoblastic-neoplasia-after-controlling-for-risk-factors
#5
Patrícia Rangel Sobral Dantas, Izildinha Maestá, Jorge Rezende Filho, Joffre Amin Junior, Kevin M Elias, Neil Howoritz, Antonio Braga, Ross S Berkowitz
OBJECTIVE: To evaluate the influence of hormonal contraception (HC) on the development and clinical aggressiveness of gestational trophoblastic neoplasia (GTN) and the time for normalization of human chorionic gonadotropin (hCG) levels. METHODS: A retrospective cohort study was conducted with women diagnosed with molar pregnancy, followed at the Rio de Janeiro Trophoblastic Disease Center, between January 2005 and January 2015. The occurrence of postmolar GTN and the time for hCG normalization between users of HC or barrier methods (BM) during the postmolar follow-up or GTN treatment were evaluated...
September 16, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28926868/polycystic-ovary-syndrome-pcos-in-juvenile-and-adult-type-1-diabetes-in-a-german-austrian-cohort
#6
Christina Reinauer, Esther Bollow, Elke Fröhlich-Reiterer, Katharina Laubner, Dominik Bergis, Christof Schöfl, Hans-Peter Kempe, Michael Hummel, Pia Hennes, Katja Gollisch, Holger Haberland, Nicolin Datz, Thomas Meissner, Reinhard W Holl
Context While an association between PCOS and type 2 diabetes is well established, to date there have been few data on clinical care of type 1 diabetes (T1D) patients with PCOS. Objective The aim of our study was to characterize T1D patients with the comorbidity of PCOS within the DPV cohort with regard to diabetes phenotype, therapy and metabolic control. Design and Setting Clinical data from the prospective German/Austrian DPV cohort on patients with T1D and documented PCOS (n=76) were compared to female T1D controls (n=32,566) in reproductive age...
September 19, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28924583/screening-for-primary-aldosteronism-using-the-newly-developed-ids-isys%C3%A2-automated-assay-system
#7
P M O'Shea, T P Griffin, G A Browne, N Gallagher, J J Brady, M C Dennedy, M Bell, D Wall, M Fitzgibbon
BACKGROUND: The recommended approach to screening for primary aldosteronism (PA) in at-risk populations is to determine the ratio of aldosterone concentration (serum (SAC)/plasma (PAC)) to renin measured in plasma as activity (PRA) or concentration (DRC). However, lack of assay standardisation mandates the need for method-specific decision thresholds and clinical validation in the local population. AIM: The study objective was to establish method-specific aldosterone: renin ratio (ARR) cut-offs for PA in men and women using the IDS-iSYS® assay system (IDS plc)...
April 2017: Pract Lab Med
https://www.readbyqxmd.com/read/28924070/-a-case-of-cerebral-venous-sinus-thrombosis-secondary-to-subclinical-basedow-disease
#8
Ichiro Kawahara, Keisuke Toyoda, Makoto Hirose, Naoki Kitagawa
Cerebral venous sinus thrombosis(CVST)is a rare condition accounting for <1% of all strokes. It has been linked to a multitude of risk factors, including infections, oral contraceptive use, coronary disease, malignant disease, trauma, surgery, coagulopathy and several others. However, the association between hyperthyroidism and CVST is poorly understood. We describe here a rare case of CVST, secondary to subclinical Basedow disease. A 68-year-old woman with general fatigue, headache, speech disturbance and slow behavior was admitted to our hospital...
September 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28921520/anti-m%C3%A3-llerian-hormone-and-risk-of-ovarian-cancer-in-nine-cohorts
#9
Seungyoun Jung, Naomi Allen, Alan A Arslan, Laura Baglietto, Aurelio Barricarte, Louise A Brinton, Brian L Egleston, Roni T Falk, Renée T Fortner, Kathy J Helzlsouer, Yutang Gao, Annika Idahl, Rudolph Kaaks, Vittorio Krogh, Melissa A Merritt, Eva Lundin, N Charlotte Onland-Moret, Sabina Rinaldi, Helena Schock, Xiao-Ou Shu, Patrick M Sluss, Paul N Staats, Carlotta Sacerdote, Ruth C Travis, Anne Tjønneland, Antonia Trichopoulou, Shelley S Tworoger, Kala Visvanathan, Elisabete Weiderpass, Anne Zeleniuch-Jacquotte, Joanne F Dorgan
Animal and experimental data suggest that anti-Müllerian hormone (AMH) serves as a marker of ovarian reserve and inhibits the growth of ovarian tumors. However, few epidemiologic studies have examined the association between AMH and ovarian cancer risk. We conducted a nested case-control study of 302 ovarian cancer cases and 336 matched controls from nine cohorts. Prediagnostic blood samples of premenopausal women were assayed for AMH using a picoAMH enzyme-linked immunosorbent assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable-adjusted conditional logistic regression...
September 18, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28918448/a-systematic-review-of-cost-effectiveness-analysis-of-screening-interventions-for-assessing-the-risk-of-venous-thromboembolism-in-women-considering-combined-oral-contraceptives
#10
REVIEW
Zanfina Ademi, C Simone Sutherland, Joris Van Stiphout, Jöelle Michaud, Goranka Tanackovic, Matthias Schwenkglenks
Use of combined oral contraceptives (COCs) by women increases the risk of venous thromboembolism (VTE), which can have a major impact on an individuals' quality of life. VTE is also associated with an increase in healthcare costs. Our aim was to systematically review cost-effectiveness analyses (CEAs) considering any screening for risk of VTE in women using COCs. The quality of reporting in each study was assessed, a summary of results was prepared, and the key drivers of cost effectiveness in each of the eligible CEAs were identified...
September 16, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28912620/hormonal-contraception-and-the-development-of-autoimmunity-a-review-of-the-literature
#11
William V Williams
Estrogens and progestins are known to have profound effects on the immune system and may modulate the susceptibility to autoimmune diseases. A comprehensive literature search was carried out using PubMed for any of 153 autoimmune disease terms and the terms contraception, contraceptive, or their chemical components with limits of Humans + Title or Abstract. Over 1,800 titles were returned and scanned, 352 papers retrieved and reviewed in depth and an additional 70 papers retrieved from the bibliographies. Based on this review, substantial evidence exists linking the use of combined oral contraceptives to a lower incidence of hyperthyroidism, an increase in multiple sclerosis, ulcerative colitis, Crohn's disease, Systemic Lupus Erythematosus, and interstitial cystitis...
August 2017: Linacre Quarterly
https://www.readbyqxmd.com/read/28912358/combined-oral-contraceptives-plus-spironolactone-compared-with-metformin-in-women-with-polycystic-ovary-syndrome-a-one-year-randomized-clinical-trial
#12
Macarena Alpañés, Francisco Álvarez-Blasco, Elena Fernández-Durán, Manuel Luque-Ramírez, Héctor F Escobar-Morreale
OBJECTIVE: We aimed to compare a combined oral contraceptive (COC) plus the antiandrogen spironolactone with the insulin sensitizer metformin in women with polycystic ovary syndrome (PCOS). DESIGN: We conducted a randomized, parallel, open-label, clinical trial comparing COC (30 μg of ethinylestradiol and 150 μg of desogestrel) plus spironolactone (100 mg/day) with metformin (850 mg b.i.d.) for one year in women with PCOS (EudraCT2008-004531-38). METHODS: The composite primary outcome included efficacy (amelioration of hirsutism, androgen excess and menstrual dysfunction) and cardiometabolic safety (changes in the frequencies of disorders of glucose tolerance, dyslipidemia and hypertension)...
November 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28911135/is-it-me-or-my-hormones-neuroendocrine-activation-profiles-to-visual-food-stimuli-across-the-menstrual-cycle
#13
Yardena Arnoni-Bauer, Atira Bick, Noa Raz, Tal Imbar, Shoshana Amos, Orly Agmon, Limor Marko, Netta Levin, Ram Weiss
Context: Homeostatic energy balance is controlled via the hypothalamus, whereas regions controlling reward and cognitive decision-making are critical for hedonic eating. Eating varies across the menstrual cycle peaking at the midluteal phase. Objective: To test responses of females with regular cycles during midfollicular and midluteal phase and of users of monophasic oral contraception pills (OCPs) to visual food cues. Design: Participants performed a functional magnetic resonance imaging while exposed to visual food cues in four time points: fasting and fed conditions in midfollicular and midluteal phases...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28910273/quickstats-percentage-of-women-who-missed-taking-oral-contraceptive-pills-among-women-aged-15-44-years-who-used-oral-contraceptive-pills-and-had-sexual-intercourse-overall-and-by-age-and-number-of-pills-missed-national-survey-of-family-growth-united-states
#14
https://www.readbyqxmd.com/read/28906053/the-effects-of-menstrual-cycle-phase-on-the-incidence-of-plateau-at-v%C3%AB-o2max-and-associated-cardiorespiratory-dynamics
#15
Dan Gordon, Adrian Scruton, Richard Barnes, James Baker, Luciano Prado, Viviane Merzbach
The purpose of this study was to examine the effect of menstrual cycle phase on maximal oxygen uptake (V˙O2max) and associated cardiodynamic responses. A total of 16 active females volunteered of which n = 10 formed the non-oral contraceptive pill group (n-OCP), displaying a regular menstrual cycle of 28·4 ± 2·2 days (age 20·6 ± 1·6 years, height 169·9 ± 6·4 cm, mass 68·7 ± 7·9 kg) and n = 6 formed the oral contraceptive pill group (OCP) (monophasic pill) (age 21·7 years ± 2·16, height 168·1 cm ± 6·8 cm, mass 61·6 ± 6·8 kg)...
September 14, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28905857/risk-factors-oral-contraceptive-use-linked-to-lower-risk-of-ra
#16
Sarah Onuora
No abstract text is available yet for this article.
September 14, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28904575/facial-palsy-in-cerebral-venous-thrombosis-an-atypical-case-in-a-young-girl
#17
Ayşe Kartal
Cerebral venous thrombosis (CVT) is a rare and potentially life-threating cause of stroke. A number of etiologies and risk factors for CVT have been identified so far. These include head trauma, local and systemic infectious diseases, malignancies, autoimmune diseases, and oral contraceptive use. The most common clinical symptoms are headache and changes in consciousness. Cranial nerve palsy in CVT is uncommon, and there are very few reports of facial nerve palsy. This case report highlights an atypical manifestation in a CVT patient, who presented with peripheral facial palsy...
April 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28903991/biology-and-etiology-of-young-onset-breast-cancers-among-premenopausal-african-american-women-results-from-the-amber-consortium
#18
Lynn Chollet-Hinton, Andrew F Olshan, Hazel B Nichols, Carey K Anders, Jennifer L Lund, Emma H Allott, Traci N Bethea, Chi-Chen Hong, Stephanie M Cohen, Thaer Khoury, Gary R Zirpoli, Virginia F Borges, Lynn A Rosenberg, Elisa V Bandera, Christine B Ambrosone, Julie R Palmer, Melissa A Troester
BACKGROUND: African American (AA) women have higher incidence of aggressive, young-onset (<40 years) breast cancers. Young- and older-onset disease may have distinct tumor biologies and etiologies; however, studies investigating age differences among AA women have been rare and generally underpowered. METHODS: We examined tumor characteristics and breast cancer risk factors associated with premenopausal young (<40) vs. older (≥40) AA women's breast cancer in the African American Breast Cancer Epidemiology and Risk Consortium (2,008 cases and 5,144 controls)...
September 13, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28900324/a-significant-breakthrough-in-the-incidence-of-childhood-cancers-and-evaluation-of-its-risk-factors-in-southern-iran
#19
Asma Erjaee, Maryam Niknam, Ahmadreza Sadeghi, Maryam Dehghani, Zeinab Safaei, Saeed Hosseini Teshnizi, Mehran Karimi
BACKGROUND AND OBJECTIVE: This study investigates epidemiologic and practical information about the incidence and risk factors of childhood cancer in a population of Southern Iranian children. MATERIALS AND METHODS: A total number of 300 cancer patients along with 600 age- and gender-matched healthy control were interviewed by a trained physician regarding their demographic characteristics, and major family-associated risk factors, childhood malignancies. RESULTS: The average annual percentage change for cancers in the studied population is calculated as 45%...
April 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/28894854/the-relationship-between-breast-cancer-and-risk-factors-a-single-center-study
#20
Arzu Ozsoy, Nurdan Barca, Betul Akdal Dolek, Hafize Aktaş, Eda Elverici, Levent Araz, Ozlen Ozkaraoğlu
OBJECTIVE: To determine the relationship between breast cancer and known risk factors in patients who had mammography (MG) for breast cancer screening or ultrasonography and/or MG for diagnostic purposes. MATERIALS AND METHODS: In the period of January-December, 2011, a questionnaire composed of 17 questions was applied to 2862 female patients and MG and/or US examination was performed afterwards. Chi-square and Kruskal-Wallis tests were used for statistical analysis...
July 2017: Eur J Breast Health
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