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https://www.readbyqxmd.com/read/28646558/neurology-concepts-young-women-and-ischemic-stroke-evaluation-and-management-in-the-emergency-department
#1
Bernard P Chang, Charles Wira, Joseph Miller, Murtaza Akhter, Bradley E Barth, Joshua Willey, Lauren Nentwich, Tracy Madsen
OBJECTIVE: Ischemic stroke is a leading cause of morbidity and mortality worldwide. While the incidence of ischemic stroke is highest in older populations, incidence of ischemic stroke in adults has been rising particularly rapidly among young (e.g. premenopausal) women. The evaluation and timely diagnosis of ischemic stroke in young women presents a challenging situation in the emergency department, due to a range of sex-specific risk factors and to broad differentials. The goals of this concepts paper are to summarize existing knowledge regarding the evaluation and management of young women with ischemic stroke in the acute setting...
June 24, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28642961/female-sexual-dysfunction-with-combined-oral-contraceptive-use
#2
Jean Jasmin M L Lee, Thiam Chye Tan, Seng Bin Ang
Combined oral contraceptive pills (COCs) remain one of the most popular forms of contraception to prevent unwanted pregnancy in women. While it is known that COCs can cause sexual dysfunction in women, there is currently no recommendation to screen for sexual function before and after initiation of COCs. We propose that, based on the evidence available, assessment of sexual function should be done at initiation of COCs, as well as at regular intervals thereafter. This would allow COC-related sexual dysfunction to be managed early, such as by switching the patient to newer-generation COCs or other forms of contraception...
June 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28641030/estetrol-combined-with-drospirenone-an-oral-contraceptive-with-high-acceptability-user-satisfaction-well-being-and-favourable-body-weight-control
#3
Dan Apter, Yvette Zimmerman, Louise Beekman, Marie Mawet, Catherine Maillard, Jean-Michel Foidart, Herjan J T Coelingh Bennink
OBJECTIVES: This study evaluated acceptability, user satisfaction, body weight control and general well-being of estetrol (E4) combined with either drospirenone (DRSP) or levonorgestrel (LNG). METHODS: In this open-label, multi-centre, dose-finding, 6-cycle study, 396 healthy women of reproductive age were randomised into five treatment groups in a 24/4-day regimen: 15 mg or 20 mg E4 combined with either 3 mg DRSP or 150 μg LNG, and as reference estradiol valerate (E2V) combined with dienogest (DNG)...
June 22, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28640224/nomegestrol-acetate-suppresses-human-endometrial-cancer-rl95-2-cells-proliferation-in-vitro-and-in-vivo-possibly-related-to-upregulating-expression-of-sufu-and-wnt7a
#4
A-Ying Ma, Shu-Wu Xie, Jie-Yun Zhou, Yan Zhu
Nomegestrol acetate (NOMAC) has been successfully used for the treatment of some gynecological disorders, and as a combined oral contraceptive with approval in many countries. In this study, we investigated the effects of NOMAC on human endometrial cancer cells in vitro and in vivo. The proliferation of human endometrial cancer cells (RL95-2 and KLE) were assessed using CCK-8 and EdU incorporation assays. Whole-genome cDNA microarray analysis was used to identify the effects of NOMAC on gene expression profiles in RL95-2 cells...
June 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28638292/combined-oral-contraceptive-pill-initiation-in-a-patient-with-major-depressive-disorder-premenstrual-dysphoric-disorder-social-anxiety-panic-disorder-and-histrionic-personality-disorder
#5
Cody Roi, Erich J Conrad
BACKGROUND: Comorbid psychiatric conditions present an added layer of challenge in managing patients, as each condition and associated set of symptoms exacerbate the complexity of the overall presentation. Premenopausal women may be at particular risk for inadequate care, as their comorbid conditions may present overlapping symptoms and mask independent premenstrual symptoms. The prevalence of premenstrual dysphoric disorder and associated conditions can be as high as 8% in women of reproductive age...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28625324/esr2-genetic-variants-and-combined-oral-contraceptive-use-associated-with-the-risk-of-stroke
#6
Zhenlin Xu, Ying Li, Xiaoping Huang, Wei Shen, Jianling Bai, Chong Shen, Yang Zhao
BACKGROUND AND AIM: There is accumulating evidence suggesting an important role of estrogen receptor-β in the development of cardiovascular disease. The present study aims to investigate the relationship of estrogen receptor β gene (ESR2) polymorphisms with stroke risk in Chinese women, and further evaluate the gene-environment interaction of ESR2 and combined oral contraceptive (COC) use on stroke risk. METHODS: A case-control study was conducted with 446 first-ever stroke patients and 864 control subjects recruited from our prospective female cohort...
February 2017: Archives of Medical Research
https://www.readbyqxmd.com/read/28619581/-cardiovascular-risk-of-smoking-by-gender
#7
Daniel Thomas
In France, the increase in the prevalence of women's smoking has been major over the past 30 years. The consequences are a significant increase and an unusual precocity of all the women's cardiovascular (CV) pathologies (myocardial infarction, stroke and aortic pathologies). Associated factors (combined oral contraception, unequal distribution of other CV risk factors by sex) increase the CV impact of women's smoking. For the same tobacco use, women have a 25% higher risk of coronary heart disease than men...
June 12, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28619391/pharmacists-attitudes-regarding-provision-of-sexual-and-reproductive-health-services
#8
Austin T Hilverding, Natalie A DiPietro Mager
OBJECTIVES: The primary objective was to assess attitudes from Ohio pharmacists about contraceptive authority. Secondary objectives included determining pharmacists' perceptions of benefits, barriers, and preparedness for offering such services and examining attitudes about and experiences with other reproductive health topics to inform future research. METHODS: An anonymous 26-question Institutional Review Board-approved electronic survey was developed and distributed via Qualtrics to a random sample of 500 licensed pharmacists in Ohio...
June 12, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28613432/medical-therapy-for-preventing-recurrent-endometriosis-after-conservative-surgery-a-cost-effectiveness-analysis
#9
Bin Wu, Zhiyou Yang, Ruoyan Gai Tobe, Yu Wang
OBJECTIVE: To assess the cost-effectiveness of different strategies, including the gonadotropin-releasing hormone agonist (GnRH-a) and oral contraceptive therapy, for the prevention of endometriosis recurrence after conservative surgery. DESIGN: Cost-effectiveness analysis from a health care perspective. SETTING: Chinese setting represented as a health resource limited setting. POPULATION: patients who undergo laparoscopic or laparotomic conservative surgery for endometriosis...
June 14, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28612598/relationship-between-breast-cancer-and-oral-contraceptive-use-among-thai-premenopausal-women-a-case-control-study
#10
Wisit Chaveepojnkamjorn, Natchaporn Pichainarong, Rungsinoppadol Thotong, Pratana Sativipawee, Supachai Pitikultang
Background: Breast cancer (BC) is an important issue both in medicine and public health as it is the leading malignancy with high incidence and mortality among women worldwide. The objective of this research was to determine the associations of BC with oral contraceptive (OC) use among Thai premenopausal women (TPW). Materials and Methods: A case-control study was conducted among TPW attending the National Cancer Institute, with 257 cases and 257 controls in 2013-2014. Cases and controls were matched by age (± 5 years), residential area and duration of attendance...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28612347/association-between-duration-of-oral-contraceptive-use-and-risk-of-hypertension-a-meta-analysis
#11
Hui Liu, Jie Yao, Weijing Wang, Dongfeng Zhang
A meta-analysis was conducted to evaluate the association between duration of oral contraceptive use and risk of hypertension. Relevant studies published in English or Chinese were identified by a search of PubMed, Web of Science, Wanfang Database, and China National Knowledge Infrastructure to January 2017. Seventeen articles containing 24 studies with 270,284 participants were included in this meta-analysis. The pooled relative risk of hypertension for the highest vs lowest category of oral contraceptive duration was 1...
June 13, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28612340/long-acting-systemic-hiv-pre-exposure-prophylaxis-an-examination-of-the-field
#12
REVIEW
William R Lykins, Ellen Luecke, Daniel Johengen, Ariane van der Straten, Tejal A Desai
Oral pre-exposure prophylaxis for the prevention of HIV-1 transmission (HIV PrEP) has been widely successful as demonstrated by a number of clinical trials. However, studies have also demonstrated the need for patients to tightly adhere to oral dosing regimens in order to maintain protective plasma and tissue concentrations. This is especially true for women, who experience less forgiveness from dose skipping than men in clinical trials of HIV PrEP. There is increasing interest in long-acting (LA), user-independent forms of HIV PrEP that could overcome this adherence challenge...
June 13, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28611442/competing-factors-link-to-bone-health-in-polycystic-ovary-syndrome-chronic-low-grade-inflammation-takes-a-toll
#13
Shirin Kalyan, Millan S Patel, Elaine Kingwell, Hélène C F Côté, Danmei Liu, Jerilynn C Prior
Chronic inflammation predisposes to poor bone health. Women with polycystic ovary syndrome (PCOS) experience androgen excess, ovulatory disturbances, insulin resistance, abdominal adiposity and chronic inflammation. Our objective was to investigate the relationships among bone health parameters, chronic subclinical inflammation and anthropometric measures in premenopausal women with and without PCOS. In 61 premenopausal women, 22 women with PCOS and 39 controls, we assessed bone parameters (total hip bone mineral density [BMD] by dual-energy X-ray absorptiometry and radius strength-strain index [SSI] by peripheral quantitative computed tomography), inflammation (C-reactive protein/albumin), oxidative stress (leukocyte telomere length, urinary 8-hydroxydeoxyguanosine); hemoglobin A1c; anthropometric measures (body mass index, waist-to-height ratio, cross-sectional muscle area)...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28608970/effect-of-extended-oral-contraception-use-on-the-prevalence-of-fetal-trisomy-21-in-women-aged-at-least-35-years
#14
Dániel Horányi, Lilla Éva Babay, János Rigó, Balázs Győrffy, Gyula R Nagy
OBJECTIVE: To study factors influencing the number of ovulations in reproductive life as risk factors for common trisomies. METHODS: The present observational study examined data from genetic counseling sessions performed at the 1st Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary, between September 1, 2013, and September 1, 2015, and retrieved data on patients of advanced maternal age (≥35 years) who had fetal trisomy 21, 18, or 13 confirmed...
June 13, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28598795/determination-of-reference-intervals-for-urinary-steroid-profiling-using-a-newly-validated-gc-ms-ms-method
#15
Wilhelmina H A de Jong, Edward Buitenwerf, Alle T Pranger, Ineke J Riphagen, Bruce H R Wolffenbuttel, Michiel N Kerstens, Ido P Kema
BACKGROUND: Urinary steroid profiling (USP) is a powerful diagnostic tool to asses disorders of steroidogenesis. Pre-analytical factors such as age, sex and use of oral contraceptive pills (OCP) may affect steroid hormone synthesis and metabolism. In general, USP reference intervals are not adjusted for these variables. In this study we aimed to establish such reference intervals using a newly-developed and validated gas chromatography with tandem mass spectrometry detection method (GC-MS/MS)...
June 9, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28597617/iron-monitoring-of-male-and-female-rugby-sevens-players-over-an-international-season
#16
Anthea C Clarke, Judith M Anson, Christine E Dziedzic, Warren A McDonald, David B Pyne
BACKGROUND: Given the likely influence that high training loads, contact-induced haemolysis and female-specific requirements have on the incidence of iron deficiency, characterising the direction and magnitude of fluctuations in iron status over an international season is important for managing player health and physical performance in rugby sevens. METHODS: Australian national male (n=27) and female (n=23) rugby sevens players undertook blood tests at pre-season, mid-season, and end-season...
June 8, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28596121/one-year-continuation-of-copper-or-levonorgestrel-intrauterine-devices-initiated-at-the-time-of-emergency-contraception
#17
J N Sanders, D K Turok, P A Royer, I S Thompson, L M Gawron, K E Storck
OBJECTIVE(S): This study compares one-year intrauterine device (IUD) continuation among women presenting for emergency contraception (EC) and initiating the copper (Cu T380A) IUD or the levonorgestrel (LNG) 52 mg IUD plus 1.5 mg oral LNG. STUDY DESIGN: This cohort study enrolled 188 women who presented at a single family planning clinic in Utah between June 2013 and September 2014 and selected either the Cu T380A IUD or LNG 52 mg IUD plus oral LNG for EC. Trained personnel followed participants by phone, text, or email for twelve months or until discontinuation occurred...
June 5, 2017: Contraception
https://www.readbyqxmd.com/read/28595972/17%C3%AE-ethynylestradiol-alters-the-peritoneal-immune-response-of-gilthead-seabream
#18
N E Gómez González, I Cabas, M C Rodenas, M Arizcun, V Mulero, A García Ayala
17α-Ethynylestradiol (EE2), a synthetic estrogen used in most oral contraceptives pills and hormone replacement therapies, is found in many water bodies, where it can modulate the fish immune response. EE2 acts as an endocrine disruptor in gilthead seabream, Sparus aurata L., a marine teleost fish of great economic value in Mediterranean aquaculture, as it induces hepatic vitellogenin gene (vtg) expression. Moreover, EE2 also alters the capacity of gilthead seabream to appropriately respond to infection although it does not behave as an immunosuppressor...
June 9, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28590310/medical-management-of-endometriosis
#19
Saima Rafique, Alan H Decherney
Endometriosis is a chronic medical condition that affects around 6% to 10% of reproductive age women. Pelvic pain, dysmenorrhea, and infertility are the most common presenting symptoms. The disease is characterized by estrogen-dependent growth of the endometrial glands and stroma outside the endometrial cavity. The diagnosis requires a high degree of suspicion and can be only confirmed on histopathology. Treatment includes medical and surgical options. Both hormonal and nonhormonal medical options are available and are tried at first with a goal to control pain and stop the growth of the endometriotic lesions...
June 5, 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28588554/female-reproductive-factors-and-differentiated-thyroid-cancer
#20
REVIEW
Mariacarla Moleti, Giacomo Sturniolo, Maria Di Mauro, Marco Russo, Francesco Vermiglio
Differentiated thyroid cancer (DTC) is markedly more common in women than men, the highest female-to-male ratio being recorded during the reproductive period. This evidence has led to the suggestion that female hormonal and reproductive factors may account for the observed DTC gender disparity. This review focuses on current evidence on the risk of DTC in conjunction with major female reproductive factors, including the impact of pregnancy on DTC occurrence and progression/recurrence. Overall, studies exploring the link between the risk of DTC and menstrual and menopausal factors, oral contraceptives and/or hormone replacement therapy, showed these associations, if any, to be generally weak...
2017: Frontiers in Endocrinology
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