Brittany N Simpson, Miguel E Mejía Sang, Yonairy Collado Puello, Elvira J Diaz Brockmans, María F Díaz Soto, Stephanie M Rivera Defilló, Karla M Taveras Cruz, Javier O Santiago Pérez, Ammar Husami, Melissa E Day, Valentina Pilipenko, Rafael Mena, Cesár Mota, Margaret K Hostetter, Louis J Muglia, Elizabeth Schlaudecker, Javier Gonzalez Del Rey, Lisa J Martin, Carlos E Prada
We performed an observational cohort study to assess associations between genetic factors of dengue fever (DF) severity in children in the Dominican Republic. A total of 488 participants had serologically confirmed DF. We replicated the association between the IFIH1 gene (rs1990760) and severe DF (n = 80/488, p = 0.006) and identified novel associations needing further investigation.
April 18, 2023: Journal of the Pediatric Infectious Diseases Society