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Milk formula rct

Dominik D Alexander, Jian Yan, Lauren C Bylsma, Robert S Northington, Dominik Grathwohl, Philippe Steenhout, Peter Erdmann, Evelyn Spivey-Krobath, Ferdinand Haschke
BACKGROUND: High protein intake during infancy may contribute to obesity later in life in infants who are not exclusively breastfed. Lowering the protein content of infant formula so it is closer to that of mature breast milk may reduce long-term risk of overweight or obesity in formula-fed infants. OBJECTIVE: We assessed the effects of whey-predominant formulas with a protein content of 1.8 g/100 kcal (lower than that in most current formulas and closer to breast milk) on infant growth by comparing against WHO growth standards and breastfed infants...
October 2016: American Journal of Clinical Nutrition
Arianna Aceti, Davide Gori, Giovanni Barone, Maria Luisa Callegari, Maria Pia Fantini, Flavia Indrio, Luca Maggio, Fabio Meneghin, Lorenzo Morelli, Gianvincenzo Zuccotti, Luigi Corvaglia
Probiotics have been linked to a reduction in the incidence of necrotizing enterocolitis and late-onset sepsis in preterm infants. Recently, probiotics have also proved to reduce time to achieve full enteral feeding (FEF). However, the relationship between FEF achievement and type of feeding in infants treated with probiotics has not been explored yet. The aim of this systematic review and meta-analysis was to evaluate the effect of probiotics in reducing time to achieve FEF in preterm infants, according to type of feeding (exclusive human milk (HM) vs...
2016: Nutrients
Roberto Berni Canani, Rita Nocerino, Tullio Frediani, Sandra Lucarelli, Carmen Di Scala, Elena Varin, Ludovica Leone, Antonella Muraro, Carlo Agostoni
OBJECTIVES: The long-term effects of amino acid-based formula (AAF) in the treatment of cow's milk allergy (CMA) is largely unexplored. This study comparatively evaluates body growth and protein metabolism in CMA children treated with AAF or with extensively hydrolysed whey formula (eHWF), and healthy controls (HCs). METHODS: A 12-month multicentre randomised control trial (RCT) was conducted in outpatients with CMA (aged 5-12 m) randomised in two groups, treated with AAF (Group 1) and eHWF (Group 2), and compared with HCs (Group 3) fed with follow-on (if age <12 m) or growing-up formula (if age >12 m)...
July 20, 2016: Journal of Pediatric Gastroenterology and Nutrition
Qian Wang, Qiliang Cui, Caiman Yan
BACKGROUND AND OBJECTIVE: Long-chain polyunsaturated fatty acids, especially docosahexaenoic acid, have been suggested as a nutrition factor affecting visual and neurobehavioral development of preterm infants. Several randomized controlled trials (RCTs) have investigated the effect of supplementation of long-chain polyunsaturated fatty acids on preterm infants. We conducted a systematic review and meta-analysis to examine the efficacy of long-chain polyunsaturated fatty acid supplementation of formula or breast milk on the neurodevelopment outcomes of preterm infants...
June 2016: Pediatric Neurology
Adam J Lewandowski, Pablo Lamata, Jane M Francis, Stefan K Piechnik, Vanessa M Ferreira, Henry Boardman, Stefan Neubauer, Atul Singhal, Paul Leeson, Alan Lucas
BACKGROUND AND OBJECTIVES: Preterm birth relates to long-term alterations in cardiac morphology and function. Understanding whether preterm postnatal life is a tractable period of cardiovascular development that can be positively altered by nutrition is relevant to long-term outcomes. We hypothesized that being fed human breast milk during early postnatal life is beneficial to long-term cardiac structure and function in preterm-born individuals compared with infant formulas. METHODS: A total of 926 preterm-born infants originally took part in a randomized controlled trial of postnatal milk-feeding regimens between 1982 and 1985 across 5 different UK centers...
July 2016: Pediatrics
Olle Hernell, Niklas Timby, Magnus Domellöf, Bo Lönnerdal
The milk fat globule membrane (MFGM) in breast milk contains many bioactive components. Infant formulas traditionally have been devoid of the MFGM fraction, but dairy technology now has made the addition of bovine MFGM technically feasible. We identified 6 double-blinded randomized controlled trials exploring the effects of MFGM supplementation on the diets of infants or children. Results suggest that supplementation is safe and indicate positive effects on both neurodevelopment and defense against infections...
June 2016: Journal of Pediatrics
R J Boyle, M L-K Tang, W C Chiang, M C Chua, I Ismail, A Nauta, J O'B Hourihane, P Smith, M Gold, J Ziegler, J Peake, P Quinn, R Rao, N Brown, A Rijnierse, J Garssen, J O Warner
BACKGROUND: Prevention guidelines for infants at high risk of allergic disease recommend hydrolysed formula if formula is introduced before 6 months, but evidence is mixed. Adding specific oligosaccharides may improve outcomes. OBJECTIVE: To evaluate whether partially hydrolysed whey formula containing oligosaccharides (0.8 g/100 ml) (pHF-OS) can prevent eczema in high-risk infants [ISRCTN65195597]. METHODS: We conducted a parallel-group, multicentre, randomized double-blind controlled trial of pHF-OS vs standard cow's milk formula...
May 2016: Allergy
Piotr Socha, Christian Hellmuth, Dariusz Gruszfeld, Hans Demmelmair, Peter Rzehak, Veit Grote, Martina Weber, Joaquin Escribano, Ricardo Closa-Monasterolo, Elena Dain, Jean-Paul Langhendries, Enrica Riva, Elvira Verduci, Berthold Koletzko
There is growing evidence of long-term effects of early dietary intervention in infancy on later obesity risk. Many studies showed reduced risk of obesity with breastfeeding in infancy, which could be related to the reduced protein intake with human milk compared to infant formula. In a randomized controlled trial (Childhood Obesity Project), we were able to show that infant formula with reduced protein content results in lower BMI both at 2 and 6 years. These effects seem to be mediated mainly by branched-chain amino acids which stimulate the insulin-like growth factor (IGF)-1 axis and insulin release...
2016: Nestlé Nutrition Institute Workshop Series
Amir-Mohammad Armanian, Alireza Sadeghnia, Maryam Hoseinzadeh, Maryam Mirlohi, Awat Feizi, Nima Salehimehr, Moloud Torkan, Zahra Shirani
OBJECTIVE: This study was designed to compare the efficacy and safety of enteral supplementation of a prebiotic mixture (SCGOS/LCFOS) on faecal microbiota in very premature infants who fed exclusively with human-milk. METHODS: This double-center randomized control trial was conducted from December 2012 to November 2013 in the tertiary Neonatal Intensive Care Units of the Isfahan University of Medical Sciences. Fifty preterm infants (birth weight ≤1500 g who were not fed with formula) were randomly allocated to have enteral (tube feeding) supplementation with a prebiotic mixture (SCGOS/LCFOS; 9:1) or receive no prebiotics...
January 2016: Journal of Research in Pharmacy Practice
Zahra Izadi, Mahmoud Sheikh-Zeinoddin, Ali A Ensafi, Sabihe Soleimanian-Zad
This paper describes fabrication of a DNA-based Au-nanoparticle modified pencil graphite electrode (PGE) biosensor for detection of Bacillus cereus, causative agent of two types of food-borne disease, i.e., emetic and diarrheal syndrome. The sensing element of the biosensor was comprised of gold nanoparticles (GNPs) self-assembled with single-stranded DNA (ssDNA) of nheA gene immobilized with thiol linker on the GNPs modified PGE. The size, shape and dispersion of the GNPs were characterized by field emission scanning electron microscope (FESEM)...
June 15, 2016: Biosensors & Bioelectronics
Bernadeta Patro-Gołąb, Bartłomiej M Zalewski, Stefanie Mp Kouwenhoven, Jacek Karaś, Berthold Koletzko, Johannes Bernard van Goudoever, Hania Szajewska
BACKGROUND: Protein intake may influence important health outcomes in later life. OBJECTIVE: The objective of this study was to investigate current evidence on the effects of infant formulas and follow-on formulas with different protein concentrations on infants' and children's growth, body composition, and later risk of overweight and obesity. METHODS: In this systematic review, we searched electronic databases (including MEDLINE, Embase, and the Cochrane Library) up until November 2014 for randomized controlled trials (RCTs)...
March 2016: Journal of Nutrition
Michelle L Baack, Susan E Puumala, Stephen E Messier, Deborah K Pritchett, William S Harris
Docosahexaenoic acid (DHA) is an essential fatty acid (FA) important for health and neurodevelopment. Premature infants are at risk of DHA deficiency and circulating levels directly correlate with health outcomes. Most supplementation strategies have focused on increasing DHA content in mother's milk or infant formula. However, extremely premature infants may not reach full feedings for weeks and commercially available parenteral lipid emulsions do not contain preformed DHA, so blood levels decline rapidly after birth...
April 2016: Lipids
Ivan D Florez, Reem Al-Khalifah, Javier M Sierra, Claudia M Granados, Juan J Yepes-Nuñez, Carlos Cuello-Garcia, Giordano Perez-Gaxiola, Adriana M Zea, Gilma N Hernandez, Areti-Angeliki Veroniki, Gordon H Guyatt, Lehana Thabane
BACKGROUND: Acute diarrhea and acute gastroenteritis (AD/AGE) are common among children in low- and middle-income countries (LMIC) and high-income countries (HIC). Supportive therapy including maintaining feeding, prevention of dehydration, and use of oral rehydration solution (ORS), is the mainstay of treatment in all children. Several additional treatments aiming to reduce the episode duration have been compared to placebo, but the differences in effectiveness among them are unknown...
2016: Systematic Reviews
Elisa Civardi, Francesca Garofoli, Stefania Longo, Maria Elisa Mongini, Beatrice Grenci, Iolanda Mazzucchelli, Micol Angelini, Annamaria Castellazzi, Francesca Fasano, Alessia Grinzato, Vassilios Fanos, Andrea Budelli, Mauro Stronati
BACKGROUND & AIMS: Safety and growth adequacy of infant formulae enriched by functional ingredients need stringent evaluation by means of randomized controlled trials (RCTs), therefore we performed a double-blind RCT to evaluate an infant formula enriched with galacto-oligosaccharides, beta-palmitate, and acidified milk vs. a standard infant formula. METHODS: Weight, length, head circumference and fecal bacteria (Bifidobacteria, BIF/Clostridia, CLO) were measured in healthy full term infants, at baseline - as before 21 days of life - at 60 and 135 days thereafter...
November 27, 2015: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Zhenmin Liu, Nicole C Roy, Yanhong Guo, Hongxin Jia, Leigh Ryan, Linda Samuelsson, Ancy Thomas, Jeff Plowman, Stefan Clerens, Li Day, Wayne Young
BACKGROUND: In the absence of human breast milk, infant and follow-on formulas can still promote efficient growth and development. However, infant formulas can differ in their nutritional value. OBJECTIVE: The objective of this study was to compare the effects of human milk (HM) and infant formulas in human infants and a weanling rat model. METHODS: In a 3 wk clinical randomized controlled trial, babies (7- to 90-d-old, male-to-female ratio 1:1) were exclusively breastfed (BF), exclusively fed Synlait Pure Canterbury Stage 1 infant formula (SPCF), or fed assorted standard formulas (SFs) purchased by their parents...
February 2016: Journal of Nutrition
K Simmer, C Kok, K Nancarrow, A R Hepworth, D T Geddes
OBJECTIVE: We aimed to determine if a novel feeding system where milk only flowed when the preterm infant created a vacuum would influence time to full oral feeds, the length of stay (LOS) in hospital and breastfeeding at discharge. STUDY DESIGN: This was a randomized controlled trial in the tertiary neonatal intensive care unit at King Edward Memorial Hospital, Perth, Australia. Eligibility criteria were: preterm infants of gestational age 25 to 34 weeks receiving >75% human milk by gastric tube...
March 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
Meihong Xu, Yibin Wang, Zhiyong Dai, Yanchun Zhang, Yong Li, Junbo Wang
OBJECTIVE: To compare the growth and nutritional status of infants fed goat milk-based formula (GMF) and cow milk-based formula (CMF). METHODS: The study was conducted in Beijing, China. It was a double-blind randomized controlled trial. A total of 79 infants aged 0-3 months old were recruited and randomized in GMF or CMF group. The infants were fed the allocated formula to 6 months. The weight, length, and head circumference were measured at the enrolment, 3 and 6 months...
2015: Food & Nutrition Research
Ke Chen, Lingying Chai, Hua Li, Ying Zhang, Hu-Mina Xie, Jia Shang, Weizheng Tian, Ping Yang, Alice C Jiang
OBJECTIVE: The aim of this study was to evaluate the effect of supplementation with bovine lactoferrin (bLf) from iron-fortified formulas on diarrhea and respiratory tract infections (RTIs) in weaned infants. METHODS: In this prospective, multicenter, controlled intervention study, 260 infants ages 4 to 6 mo who previously were exclusively breastfed but weaned were randomized into two groups: a lactoferrin-fortified formula milk group (fortified group, FG, containing lactoferrin 38 mg/100 g milk) and a no lactoferrin-fortified milk (control group, CG); breastfed infants were enrolled and served as a reference group (breastfed group, BG)...
February 2016: Nutrition
William H Johnston, Claude Ashley, Michael Yeiser, Cheryl L Harris, Suzanne I Stolz, Jennifer L Wampler, Anja Wittke, Timothy R Cooper
BACKGROUND: Human milk provides necessary macronutrients (protein, carbohydrate, fat) required for infant nutrition. Lactoferrin (Lf), a multifunctional iron-binding protein predominant in human milk, shares similar protein sequence, structure, and bioactivity with bovine Lf (bLf). This large-scale pediatric nutrition study was designed to evaluate growth and tolerance in healthy infants who received study formulas with bLf at concentrations within the range of mature human milk. METHODS: In this multi-center, double-blind, parallel-designed, gender-stratified prospective study 480 infants were randomized to receive a marketed routine cow's milk-based infant formula (Control; n = 155) or one of two investigational formulas with bLf at 0...
2015: BMC Pediatrics
Li-Ping Yin, Li-Juan Qian, Huan Zhu, Yan Chen, Han Li, Ji-Nan Han, Li-Xing Qiao
BACKGROUND: The average incidence of preterm birth in the world is up to 11.1 %, and deaths of preterm children account for more than 50 % of neonatal deaths. Gastrointestinal function of preterm children with a gestational age less than 34 weeks is immaturely developed. For preterm children who can only be fed with formula due to their mothers' sickness, choosing a suitable formula can not only meet the high nutritional needs of preterm children, but also solve their low gastrointestinal tolerability, and is thus very important...
2015: Trials
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