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N Padrón-Pérez, J Català-Mora, J Díaz, L Arias, J Prat, J M Caminal
PurposeTo explore the structural features of juvenile X-linked retinoschisis (XLRS) using swept-source-optical coherence tomography (SS-OCT) and optical coherence tomography angiography (OCT-A).DesignRetrospective, observational cross-sectional study.Patients and methodsNine patients (18 eyes) diagnosed with juvenile XLRS were included. SS-OCT and OCT-A were used to evaluate the characteristics of the inner/outer retina and the choroid.ResultsSS-OCT showed that the inner nuclear layer (INL) was the most commonly affected area (16/18 eyes; 89%)...
January 5, 2018: Eye
Won June Lee, Young Kook Kim, Jin Wook Jeoung, Ki Ho Park
Purpose: To determine the usefulness of swept-source optical coherence tomography (SS-OCT) probability maps in detecting locations with significant reduction in visual field (VF) sensitivity or predicting future VF changes, in patients with classically defined preperimetric glaucoma (PPG). Methods: Of 43 PPG patients, 43 eyes were followed-up on every 6 months for at least 2 years were analyzed in this longitudinal study. The patients underwent wide-field SS-OCT scanning and standard automated perimetry (SAP) at the time of enrollment...
December 1, 2017: Investigative Ophthalmology & Visual Science
Josef Maertz, Jan Philip Kolb, Thomas Klein, Kathrin J Mohler, Matthias Eibl, Wolfgang Wieser, Robert Huber, Siegfried Priglinger, Armin Wolf
PURPOSE: To demonstrate papillary imaging of eyes with optic disc pits (ODP) or optic disc pit associated maculopathy (ODP-M) with ultrahigh-speed swept-source optical coherence tomography (SS-OCT) at 1.68 million A-scans/s. To generate 3D-renderings of the papillary area with 3D volume-reconstructions of the ODP and highly resolved en face images from a single densely-sampled megahertz-OCT (MHz-OCT) dataset for investigation of ODP-characteristics. METHODS: A 1...
December 14, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
Daniel Velazquez-Villoria, Analia Azaro, Jordi Rodon, Cinta Hierro, Danai Kyriakou, Jose Garcia-Arumi, Miguel Angel Zapata
AIMS: To describe novel ocular toxicity in patients with metastatic cancer undergoing chemotherapy with fibroblast growth factor receptor (FGFR) inhibitors. METHODS: This observational case series study included five patients with advanced cancer who received selected pan-FGFR inhibitors as single chemotherapy in the framework of a dose-finding study and phase I and phase II clinical studies. In all cases, subfoveal neurosensory retinal detachment was diagnosed...
December 7, 2017: British Journal of Ophthalmology
Dong Yoon Kim, Jiho Song, Jin Young Kim, Kyungpil Choi, Sungmin Hyung, Ju Byung Chae
Purpose: The purpose of this study was to evaluate the effect of gravity acceleration on choroidal and retinal nerve fiber layer (RNFL) thickness using swept-source optical coherence tomography (SS-OCT). Methods: Thirteen healthy volunteers who planned to participate in human centrifuge training as part of the flight surgeon selection process enrolled this study. During centrifuge training, gravity was gradually increased up to six times that of sea level. All subjects underwent complete ophthalmologic examination and three-dimensional wide-scanning SS-OCT imaging (DRI OCT-1 Atlantis; Topcon, Tokyo, Japan)...
December 1, 2017: Investigative Ophthalmology & Visual Science
Brijesh Takkar, Shorya Azad, Jyoti Shakrawal, Nripen Gaur, Pradeep Venkatesh
This report demonstrates the blood flow pattern in a case of choroidal hemangioma (CH) using swept-source-optical coherence tomography angiography (SS-OCTA). Fluorescein angiography, SS-OCT, and SS-OCTA images of a patient with CH were obtained using a standard protocol. The internal vascular pattern of the tumor was identified on both OCT and OCTA. Dark areas were identified in the CH. These were interspersed between areas of visible blood flow, as imaged on SS-OCTA. Peripheral vascular arcades were also identified within the tumor...
November 2017: Indian Journal of Ophthalmology
Kai Gao, Fei Li, Tin Aung, Xiulan Zhang
Purpose: To characterize the diurnal variations in the dimensions of the Schlemm's canal (SC) and its association with intraocular pressure (IOP) using swept-source optical coherence tomography (SS-OCT). Methods: The temporal, nasal, inferior, and superior limbus of 102 eyes of 51 healthy subjects were imaged in vivo by SS-COT at 5 time points of 8 AM, 11 AM, 2 PM, 5 PM, and 8 PM. IOP was measured at the same time by Goldmann applanation tonometry (GAT). The diameter and the cross-sectional area of the SC were measured in ImageJ...
November 1, 2017: Investigative Ophthalmology & Visual Science
Yuye Ling, Xinwen Yao, Christine P Hendon
The rapid advance in swept-source optical coherence tomography (SS-OCT) technology has enabled exciting new applications in elastography, angiography, and vibrometry, where both high temporal resolution and phase stability are highly sought-after. In this paper, we present a 200 kHz SS-OCT system centered at 1321 nm by using an electro-optically tuned swept source. The proposed system's performance was fully characterized, and it possesses superior phase stability (0.0012% scanning variability and <1 ns timing jitter) that is promising for many phase-sensitive imaging applications...
August 1, 2017: Biomedical Optics Express
Naoki Miura, Kazuko Omodaka, Koudai Kimura, Akiko Matsumoto, Tsutomu Kikawa, Seri Takahashi, Naoko Takada, Hidetoshi Takahashi, Kazuichi Maruyama, Masahiro Akiba, Tetsuya Yuasa, Toru Nakazawa
PURPOSE: The assessment of retinal nerve fiber layer defects (RNFLDs) is a useful part of glaucoma care. Here, we obtained en-face images of retinal layers below the inner limiting membrane (ILM) with swept source-optical coherence tomography (SS-OCT), and measured RNFLD angle with new software. METHODS: This study included 105 eyes of 105 normal tension glaucoma (NTG) patients (age, 59.8 ± 13.2). Exclusion criteria were best-corrected visual acuity < 0.5, axial length > 28 mm, non-glaucoma ocular disease, and systemic disease affecting the visual field...
2017: PloS One
Magdy Moussa, Mahmoud Leila, Hagar Khalid
PURPOSE: The aim of this study was to assess the efficacy of swept-source optical coherence tomography angiography (SS-OCTA) in delineating the morphology of choroidal neovascular membrane (CNV). PATIENTS AND METHODS: This was a retrospective observational case series reviewing clinical data and fundus fluorescein angiography (FFA), swept-source optical coherence tomography (SS-OCT), and SS-OCTA images of patients with CNV and comparing the findings. The swept-source technology enables deeper penetration and superior axial resolution...
2017: Clinical Ophthalmology
Wenwen Wang, Yaxin Miao, Giacomo Savini, Colm McAlinden, Hao Chen, Qingjie Hu, Qinmei Wang, Jinhai Huang
The present study was to assess the precision (repeatability and reproducibility) of a new optical biometer (OA-2000, Tomey, Japan) based on swept-source optical coherence tomography (SS-OCT) and Placido disk topography in eyes with cataracts. Seventy-eight eyes from seventy-eight patients with cataracts were evaluated. Axial length (AL), anterior chamber depth (ACD), keratometry (K) over a 2.5 mm and 3.0 mm diameter, lens thickness (LT), central corneal thickness (CCT) and white-to-white (WTW) distance were measured by 2 skilled operators...
October 23, 2017: Scientific Reports
Se-Ryong Kang, Jun-Min Kim, Sul-Hee Kim, Hee-Jung Park, Tae-Il Kim, Won-Jin Yi
The aims of this study were to develop an automatic detection technique for tooth cracks and to suggest quantitative methods for measuring gingival sulcus depth using swept-source optical coherence tomography (SS-OCT). We evaluated SS-OCT with wavelength centered at 1310 nm over a spectral bandwidth of 100 nm at a rate of 50 kHz as a new diagnostic tool for the detection of tooth cracks and gingival sulcus depth. The reliability of the SS-OCT images was verified by imaging the crack in extracted human teeth and gingival sulcus of porcine sample...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Luis Emilio Pablo, Maria Pilar Bambo, Beatriz Cameo, Blanca Ferrández, Noemí Güerri, Vicente Polo, Jose Manuel Larrosa, Javier Moreno-Montañés, Elena Garcia-Martin
PURPOSE: To evaluate automatic peripapillary choroidal thickness (PPCT) measurements in a wide area around the optic disc and various established zones in primary open-angle glaucoma (POAG) patients and age- and sex-matched healthy controls using a new swept-source optical coherence tomography (SS-OCT) device. STUDY DESIGN: Single center cross-sectional observational study. METHODS: A total of 135 POAG patients and 86 healthy subjects were consecutively enrolled...
October 11, 2017: Japanese Journal of Ophthalmology
Giacomo Savini, Kenneth J Hoffer, H John Shammas, Jaime Aramberri, Jinhai Huang, Piero Barboni
PURPOSE: To investigate the accuracy of the measurements provided by a new optical biometer (OA-2000, Tomey Corporation, Nagoya, Japan) for calculating the intraocular lens (IOL) power and to compare the refractive outcomes to those obtained with the IOLMaster 500 (Carl Zeiss Meditec, Jena, Germany). METHODS: In this interventional multicenter study, consecutive patients having cataract surgery were enrolled. Only the IOL model used in the largest sample of patients was selected and the eyes implanted with that IOL were subsequently analyzed...
October 1, 2017: Journal of Refractive Surgery
Jay C Wang, Inês Laíns, Joana Providência, Grayson W Armstrong, Ana R Santos, Pedro Gil, João Gil, Katherine E Talcott, João H Marques, João Figueira, Demetrios G Vavvas, Ivana K Kim, Joan W Miller, Deeba Husain, Rufino Silva, John B Miller
PURPOSE: To compare choroidal vascular density (CVD) and volume (CVV) in diabetic eyes and controls, using en face swept-source optical coherence tomography (SS-OCT). DESIGN: Prospective cross-sectional study. METHODS: ▪▪▪ SETTING: Multicenter PATIENT POPULATION: 143 diabetic eyes - 27 with no diabetic retinopathy (DR), 47 with nonproliferative DR (NPDR), 51 with NPDR and diabetic macular edema (DME), and 18 with proliferative DR (PDR), and 64 age-matched non-diabetic control eyes...
October 5, 2017: American Journal of Ophthalmology
Daniela Montorio, Chiara Giuffrè, Elisabetta Miserocchi, Giulio Modorati, Riccardo Sacconi, Stefano Mercuri, Lea Querques, Giuseppe Querques, Francesco Bandello
BACKGROUND/AIMS: To analyse choroidal vascular density of affected and non-affected areas in active and inactive serpiginouschoroiditis (SC) by means of optical coherence tomography angiography (OCT-A). METHODS: In this cross-sectional and observational study, 22 eyes of 11 patients diagnosed with SC were included. All patients underwent blue-light fundus autofluorescence (spectralis Heidelberg retinalangiography+OCT) and swept-source OCT-A (AngioPlex Elite 9000 SS-OCT, Carl Zeiss Meditech) to analyse qualitative features and choroidal vessel density of areas considered affected, and the inner and the outer border of the lesions...
October 5, 2017: British Journal of Ophthalmology
Seong Joon Ahn, Jooyoung Joung, Han Woong Lim, Byung Ro Lee
PURPOSE: To investigate the distribution of outer retinal changes in hydroxychloroquine (HCQ) retinopathy and explore optical coherence tomography (OCT) protocols to maximize the sensitivity of HCQ retinopathy detection in Asian patients. DESIGN: Diagnostic validity assessment METHODS: Setting: Institutional Patient Population: Forty-eight eyes (24 patients) with HCQ retinopathy underwent 6-mm horizontal and vertical line scans and 6 × 6-mm(2) volume scans using spectral-domain OCT (SD-OCT), and 9-mm line scans and 6 × 6-mm(2) and 12 × 9-mm(2) volume scans using swept-source OCT (SS-OCT)...
September 27, 2017: American Journal of Ophthalmology
João R de Oliveira Dias, Qinqin Zhang, José M B Garcia, Fang Zheng, Elie H Motulsky, Luiz Roisman, Andrew Miller, Chieh-Li Chen, Sophie Kubach, Luis de Sisternes, Mary K Durbin, William Feuer, Ruikang K Wang, Giovanni Gregori, Philip J Rosenfeld
PURPOSE: Swept-source (SS) OCT angiography (OCTA) was used to determine the prevalence, incidence, and natural history of subclinical macular neovascularization (MNV) in eyes with nonexudative age-related macular degeneration (AMD). DESIGN: Prospective, observational, consecutive case series. PARTICIPANTS: Patients with intermediate AMD (iAMD) or geographic atrophy (GA) secondary to nonexudative AMD in 1 eye and exudative AMD in the fellow eye...
September 27, 2017: Ophthalmology
Thwe Zin Ei, Yasushi Shimada, Syozi Nakashima, Maria Jacinta Rosario H Romero, Yasunori Sumi, Junji Tagami
This study compared resin-based and glass ionomer sealants with regard to their fluoride-release behavior and anti-demineralization potential on adjacent unsealed enamel surfaces. Sealant cavities prepared on bovine enamel blocks were filled with fluoride-containing resin sealants [TeethmateF-1 (TF), Clinpro(TM) (CP)], and glass ionomer sealant [Fuji VII (FVII)]. Specimens were then incubated in artificial saliva for 14 days to measure fluoride. Thereafter, demineralization was performed for 10 days, and the anti-demineralization efficacy was assessed by Swept Source Optical Coherence Tomography (SS-OCT), and cross-sectional nanohardness...
September 28, 2017: Dental Materials Journal
Tryfon Rotsos, Konstantinos Andreanos, Stelios Blounas, Dimitrios Brouzas, Dimitrios S Ladas, Ioannis D Ladas
RATIONALE: To investigate malignant hypertension ocular lesions with swept source optical coherence tomography (SS-OCT) and optical coherence tomography angiography (OCT-A). PATIENT CONCERNS: Visual loss due to malignant hypertension. DIAGNOSES: Hypertensive chorioretinopathy. INTERVENTIONS: Patients were thoroughly examined on presentation and 30 days after their first visit, with swept-source optical coherence tomography and optical coherence tomography angiography...
September 2017: Medicine (Baltimore)
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