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JOURNAL ARTICLE
Muhammad Umer Riaz Gondal, John Lemoine, Jared Segal, Zainab Kiyani, Muhammad Ibraiz Bilal, Fawwad Ansari, Brian McCauley
INTRODUCTION: Combination-based adjuvant chemotherapy utilising capecitabine and oxaliplatin is widely used in gastric cancer treatment. Rare but severe cardiac events such as prolonged QT, cardiac arrest and cardiogenic shock can result from their use. CASE DESCRIPTION: A 45-year-old female with gastric adenocarcinoma was started on capecitabine-oxaliplatin chemotherapy one week before presenting to the emergency department with weakness. Blood pressure was 78/56 mmHg, heart rate 140 bpm and oxygen saturation 85%...
2024: European Journal of Case Reports in Internal Medicine
#2
JOURNAL ARTICLE
Mohammad Kermansaravi, Sonja Chiappetta, Chetan Parmar, Scott A Shikora, Gerhard Prager, Teresa LaMasters, Jaime Ponce, Lilian Kow, Abdelrahman Nimeri, Shanu N Kothari, Edo Aarts, Syed Imran Abbas, Ahmad Aly, Ali Aminian, Ahmad Bashir, Estuardo Behrens, Helmuth Billy, Miguel A Carbajo, Benjamin Clapp, Jean-Marc Chevallier, Ricardo V Cohen, Jerome Dargent, Bruno Dillemans, Silvia L Faria, Manoel Galvao Neto, Pierre Y Garneau, Khaled Gawdat, Ashraf Haddad, Mohamad Hayssam ElFawal, Kelvin Higa, Jaques Himpens, Farah Husain, Matthew M Hutter, Kazunori Kasama, Radwan Kassir, Amir Khan, Mousa Khoursheed, Matthew Kroh, Marina S Kurian, Wei-Jei Lee, Ken Loi, Kamal Mahawar, Corrigan L McBride, Hazem Almomani, John Melissas, Karl Miller, Monali Misra, Mario Musella, C Joe Northup, Mary O'Kane, Pavlos K Papasavas, Mariano Palermo, Richard M Peterson, Ralph Peterli, Luis Poggi, Janey S A Pratt, Aayad Alqahtani, Almino C Ramos, Karl Rheinwalt, Rui Ribeiro, Ann M Rogers, Bassem Safadi, Paulina Salminen, Sergio Santoro, Nathaniel Sann, John D Scott, Asim Shabbir, Stephanie Sogg, Erik Stenberg, Michel Suter, Antonio Torres, Surendra Ugale, Ramon Vilallonga, Cunchuan Wang, Rudolf Weiner, Natan Zundel, Luigi Angrisani, Maurizio De Luca
Metabolic and bariatric surgery (MBS) is widely considered the most effective option for treating obesity, a chronic, relapsing, and progressive disease. Recently, the American Society of Metabolic and Bariatric Surgery (ASMBS) and the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) issued new guidelines on the indications for MBS, which have superseded the previous 1991 National Institutes of Health guidelines. The aim of this study is to establish the first set of consensus guidelines for selecting procedures in Class I and II obesity, using an Expert Modified Delphi Method...
February 11, 2024: Scientific Reports
#3
JOURNAL ARTICLE
Tom Wiggins, Ojasvi Sharma, Yasmin Sarfaraz, Heather Fry, Julia Baker, Rishi Singhal
BACKGROUND: Intra-gastric balloons (IGB) are a mainstay of endoscopic treatment of overweight and obesity. In recent years, an IGB which can remain in situ for 12 months has been developed. The current study aimed to analyse the safety and efficacy of this 12-month IGB. METHODS: Consecutive patients receiving the Orbera 365TM IGB (Apollo Endosurgery, TX, USA) between September 2017 and August 2021 were included in a prospective database. Patients received regular follow-up consultations followed by endoscopic removal at 12 months...
January 2024: Obesity Surgery
#4
JOURNAL ARTICLE
Paulina Salminen, Lilian Kow, Ali Aminian, Lee M Kaplan, Abdelrahman Nimeri, Gerhard Prager, Estuardo Behrens, Kevin P White, Scott Shikora
INTRODUCTION: This survey of international experts in obesity management was conducted to achieve consensus on standardized definitions and to identify areas of consensus and non-consensus in metabolic bariatric surgery (MBS) to assist in an algorithm of clinical practice guidelines for the management of obesity. METHODS: A three-round Delphi survey with 136 statements was conducted by 43 experts in obesity management comprising 26 bariatric surgeons, 4 endoscopists, 8 endocrinologists, 2 nutritionists, 2 counsellors, an internist, and a pediatrician spanning six continents over a 2-day meeting in Hamburg, Germany...
January 2024: Obesity Surgery
#5
JOURNAL ARTICLE
A M van Dijk, M de Vries, F El-Morabit, S T Bac, M W Mundt, L E van der Schuit, M M C Hirdes, M Kara, J de Bruijne, S van Meer, H A H Kaasjager, H W de Valk, F P Vleggaar, K J van Erpecum
BACKGROUND: Data on effects of intra-gastric balloon (IGB) on metabolic dysfunction-associated steatotic liver disease (MASLD) are scarce, in part with contradictory results, and mainly obtained in tertiary care patients with diabetes and other comorbidities. We here explore effects of IGB in patients with MASLD referred to a first-line obesity clinic. METHODS: In this prospective cohort study, patients with at least significant fibrosis (≥ F2) and/or severe steatosis (S3) according to screening transient elastography (FibroScan®) were offered a second FibroScan® after 6 months lifestyle modification with or without IGB (based on patient preference)...
November 2023: Internal and Emergency Medicine
#6
JOURNAL ARTICLE
Hong-Zhao Sun, Chen-Yu Li, Yuan Shi, Jin-Jin Li, Yi-Ya Wang, Li-Na Han, Lu-Jie Zhu, Ya-Fei Zhang
BACKGROUND: Hydrogen sulfide (H2 S) is a recently discovered gaseous neurotransmitter in the nervous and gastrointestinal systems. It exerts its effects through multiple signaling pathways, impacting various physiological activities. The nucleus tractus solitarius (NTS), a vital nucleus involved in visceral sensation, was investigated in this study to understand the role of H2 S in regulating gastric function in rats. AIM: To examine whether H2 S affects the nuclear factor kappa-B (NF-κB) and transient receptor potential vanilloid 1 pathways and the neurokinin 1 (NK1) receptor in the NTS...
August 7, 2023: World Journal of Gastroenterology: WJG
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REVIEW
Mohammed S Foula, Nasser M Amer, Hazem Zakaria, Mona H Ismail, Saeed J Alshomimi, Hassan M Al Bisher, Hassan Alsaleem, Khalifa Almulhim, Abdulaziz E Aldabaeab, Hefzi Alratrout, Humood A Alsadery, Mosab A Alarfaj, Yasser M Aljehani, Ahmed M El Damati
INTRODUCTION: In Saudi Arabia, the prevalence of obesity has multiplied in the last decades leading to a surge in bariatric surgery and other endoscopic modalities. The intra-gastric balloon (IGB) is the most used endoscopic modality. Surgical management for IGB complications is required for gastrointestinal perforation and/or obstruction. However, the literature seems to underestimate these complications. MATERIALS AND METHODS: A retrospective descriptive study was conducted in King Fahd University Hospital, Saudi Arabia, from Jan 2017 to Dec 2021, including all patients with complicated IGB who necessitated any surgical procedure...
September 2023: Obesity Surgery
#8
JOURNAL ARTICLE
N J Wan, T Zhang
Childhood and adolescent obesity has become a global epidemic. The interventions mainly include lifestyle intervention, medication treatment and bariatric surgery. Among them, lifestyle intervention, especially intensive lifestyle intervention with participation of family members, is the first-line treatment for obesity in children and adolescents. Both medication and bariatric surgery are adjuvant treatments for severely obese children and adolescents. Currently, metformin is the most widely used drug for the treatment of obesity in children and adolescents in both China and other countries; orlistat and liraglutide are also the drugs that are safe and often used in other countries; other drugs are not recommended...
May 6, 2023: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
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JOURNAL ARTICLE
Masatoshi Yamano, Hiroshi Nemoto, Naoko Tsumuraya, Kohei Harigane, Yoshimi Tamura, Hiromasa Komori, Hajime Miyaji, Hideki Sarukawa, Tetsuji Wakabayashi, Naoki Yazawa, Kunihiko Shimura, Taku Miyamae
This case involved an 82-year-old man with a history of diabetes mellitus and myocardial infarction. He was undergoing treatment with 2 oral antiplatelet agents. The patient presented to our hospital for carcinomatous pyloric stenosis caused by type 4 advanced gastric cancer. Although distal gastrectomy was planned, preoperative coronary angiography revealed triple- vessel coronary artery disease. Therefore, surgery was performed under management of intra-aortic balloon pumping (IABP)therapy. The patient's hemodynamics at the time of the operation were stable, and no perioperative cardiovascular complications occurred...
December 2022: Gan to Kagaku Ryoho. Cancer & Chemotherapy
#10
JOURNAL ARTICLE
Frédéric Stucky, Barbara Uva, Bengt Kayser, Andrea Aliverti
KEY POINTS: External expiratory flow limitation (EFLe) can be applied in healthy subjects to mimic the effects of chronic obstructive pulmonary disease (COPD) and safely study the mechanisms of exercise intolerance associated with the disease. At maximal exercise intensity with EFLe, exercise intolerance results from high expiratory pressures altering the respiratory pump mechanism and limiting venous return. We used double body plethysmography to quantify blood shifting between the trunk and the extremities and examine whether the same effects occur with EFLe at submaximal exercise intensity, where the increase in expiratory pressures is milder...
November 11, 2022: Journal of Physiology
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JOURNAL ARTICLE
Jacques A Greenberg, Federico Palacardo, Rodrigo C L Edelmuth, Caitlin E Egan, Yeon Joo Lee, Felice H Schnoll-Sussman, Philip O Katz, Brendan M Finnerty, Thomas J Fahey, Rasa Zarnegar
INTRODUCTION: Roux-en-Y gastric bypass (RYGB) has been the preferred operation for obese patients with gastroesophageal reflux disease (GERD); however, some patients are hesitant to undergo bypass. Obese patients have a multifactorial predisposition to GERD, including lower esophageal sphincter (LES) dysfunction and aberrant pressure gradients across their diaphragmatic crura. Among non-obese patients, anti-reflux surgery (ARS) with hiatal hernia (HH) repair and LES augmentation has shown excellent long-term results...
October 27, 2022: Journal of Gastrointestinal Surgery
#12
REVIEW
Rajeeb Jaleel, Nitin Kapoor, Sanjay Kalra
Endoscopic intra gastric balloon placement provides an alternative method for weight loss in patients who fail to respond to life style modification, diet restriction and pharmacological therapy. Intra gastric balloon (IGB), placement can be used as a temporary measure for weight loss in obesity with or without related complications or bridge therapy in morbid obesity prior to bariatric surgery. Weight loss achieved following IGB implantation depends on the type of balloon, medium, and filling volume used for IGB inflation...
July 2022: JPMA. the Journal of the Pakistan Medical Association
#13
REVIEW
Marian Gaballah, Michael R Acord, Fernando A Escobar, Ganesh Krishnamurthy, Seth Vatsky, Abhay Srinivasan, Anne Marie Cahill
Primary percutaneous gastrostomy and gastrojejunostomy tube placements are fundamental procedures performed in pediatric interventional radiology, with both antegrade and retrograde techniques described. In pediatric patients, however, challenges may arise due to smaller patient size and anatomical variations. Several adjunctive techniques may facilitate safe percutaneous access in the setting of a limited percutaneous gastric access window. These include the intra-procedural use of cone beam computed tomography (CT), percutaneous needle decompression in the setting of distended air-filled bowel interposed between the stomach and abdominal wall, post-pyloric balloon occlusion to facilitate gastric distension, ultrasound-guided gastric puncture, and intra-gastric contrast-enhanced ultrasound (ceUS) to define the relationship of the gastric wall and the anterior abdominal wall...
September 15, 2022: Pediatric Radiology
#14
JOURNAL ARTICLE
Michael G Fadel, Matyas Fehervari, Ali Lairy, Bibek Das, Khaled Alyaqout, Hutan Ashrafian, Haris Khwaja, Evangelos Efthimiou
BACKGROUND: Laparoscopic Roux-en-Y gastric bypass (LRYGB) in patients with obesity, BMI ≥ 50 kg/m2 , can be a challenging operation. Weight loss with intra-gastric balloon (IGB) insertion prior to LRYGB may improve operative outcomes. METHODS: Between June 2000 and June 2020, patients with a BMI ≥ 50 kg/m2 underwent either IGB insertion followed by LRYGB (two-stage group), or LRYGB as the definitive bariatric procedure (single-stage group) in our institution...
September 2, 2022: Langenbeck's Archives of Surgery
#15
JOURNAL ARTICLE
Rebecca Keßler, Anne Glitsch, Björn Hübner, Simone Gärtner, Antje Steveling, Maciej Patrzyk, Wolfram Keßler
INTRODUCTION: Adiposity and excessive weight are on the rise in western industrialized countries. In cases where conservative measures fail and surgical interventions are not (yet) desired, gastric balloon therapy has proven to be a safe and reversible endoscopic method. METHODS: Aside from weight progression under gastric balloon therapy and by using MRI, our research paper describes the behavior of different abdominal body fat compartments at the beginning and at the end of the gastric balloon therapy...
August 16, 2022: Obesity Facts
#16
REVIEW
Nta Groeneveld, L van Hoeven, R S van der Crabben, C A den Uil, C Bethlehem, J Alsma
Intoxications with sodium azide are rare and in almost all cases lethal in doses above 700 mg or 10mg/kg. We report a case of a patient who ingested 2 grams of sodium azide as a suicide attempt. Sodium azide irreversible blocks cytochrome C oxidase by inhibiting oxidative phosphorylation leading to cell death. There is currently no antidote available. Our patient was treated with a range of therapies, on site, in the emergency department and in the intensive care unit, such as sodium thiosulphate, methylene blue, intralipid, extensive gastric lavage, whole bowel irrigation combined with pro-kinetics, hydroxocobalamin and exchange transfusion...
2022: Acute Medicine
#17
Marthe Emilie Berger, Uffe Schou Løve
Intragastric balloon (IGB) is a widely used, minimal invasive treatment for obesity. The IGB reduce gastric capacity and enhance feeling of fullness, thereby inducing weight loss. A rare, but severe complication to IGB treatment is gastric perforation. We present a rare case of gastric perforation, occurring shortly after a second IGB treatment. The patient was first treated with an Orbera® IGB for 12 months, exceeding the recommended treatment period of 6 months. Upon removal, esophagitis and gastritis was found...
2022: AME Case Reports
#18
JOURNAL ARTICLE
Neha R Santucci, Sarah Kemme, Khalil I El-Chammas, Maneesh Chidambaram, Manav Mathur, Daniel Castillo, Qin Sun, Lin Fei, Ajay Kaul
Background: Pyloric botulinum toxin injection has improved symptoms in children with delayed gastric emptying. We aimed to determine the clinical response to combined endoscopic intra-pyloric botulinum toxin injection and pyloric balloon dilation (IPBT-BD) in patients with dyspepsia. Methods: Electronic medical records were reviewed to gather demographic data, symptoms, and follow-up on patients with dyspepsia. Cases were defined as those who underwent IPBT-BD in addition to their ongoing management...
July 2022: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
#19
JOURNAL ARTICLE
Matthew Connell, Warren Y L Sun, Valentin Mocanu, Jerry T Dang, Janice Y Kung, Noah J Switzer, Daniel W Birch, Shahzeer Karmali
BACKGROUND: Several therapeutic modalities have been proposed for the management of choledocholithiasis (CDL) following Roux-en-Y gastric bypass (RYGB), yet debate exists regarding the optimal management. The purpose of our study was to review the current literature to compare the efficacy of various techniques in the management of CDL post-RYGB. METHODS: A comprehensive search of multiple databases was conducted. Studies reporting on the management of CDL in patients post-RYGB and including at least 5 patients were eligible for inclusion...
September 2022: Surgical Endoscopy
#20
JOURNAL ARTICLE
Lindsey J Reece, Paul Bissell, Pooja Sachdev, Neil Wright, Seema Mihrshahi, Robert J Copeland
BACKGROUND: Few treatments exist for adolescents living with severe obesity. This qualitative study explored the experiences of severely obese adolescents and their families who participated in the BOB study. METHODS: Twelve adolescents (5 males;7 females; mean age 15 years; BMI > 3.5 s.d; puberty stage 4 +) who were engaged with the research study BOB (a non-randomised, pilot novel obesity treatment programme that involved the insertion of an intra-gastric balloon coupled with a family lifestyle behavioural support programme)...
October 1, 2021: BMC Pediatrics
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