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human papillomavirus vaccination

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https://www.readbyqxmd.com/read/28319456/reactogenicity-of-cervarix-and-gardasil-human-papillomavirus-hpv-vaccines-in-a-randomized-single-blind-trial-in-healthy-uk-adolescent-females
#1
Tao Haskins-Coulter, Jo Southern, Nick Andrews, Elizabeth Miller
One hundred and ninety eight females aged 12-15 y were enrolled in an observer-blinded randomized trial to assess the immunogenicity and reactogenicity of the tetravalent HPV vaccine Gardasil® (group 2), in comparison to the bivalent HPV vaccine, Cervarix® (group 1), which was routinely offered in the national vaccination schedule at the time. Participants were blinded to treatment group until all 3 vaccinations had been given, while laboratory staff were masked during testing. For the majority of local and general reactions, recipients of both vaccines reported comparable frequencies...
March 20, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28315708/2016-international-meeting-of-the-global-virus-network
#2
REVIEW
Ramesh Akkina, Heinz Ellerbrok, William Hall, Hideki Hasagawa, Yasushi Kawaguchi, Harold Kleanthous, Edward McSweegan, Natalia Mercer, Victor Romanowski, Hirofumi Sawa, Anders Vahlne
The Global Virus Network (GVN) was established in 2011 in order to strengthen research and responses to current viral causes of human disease and to prepare against new viral pandemic threats. There are now 38 GVN Centers of Excellence and 6 Affiliate laboratories in 24 countries. GVN scientists meet annually to learn about each other's current research, address collaborative priorities and plan future programs. The 2016 meeting was held from October 23-25 in Hokkaido, Japan, in partnership with the Japanese Society for Virology, the National Institute of Infectious Diseases of Japan and the Research Center for Zoonosis Control of Hokkaido University...
March 15, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28301790/human-papillomavirus-vaccination-and-genital-warts-in-young-indigenous-australians-national-sentinel-surveillance-data
#3
Hammad Ali, Hamish McManus, Catherine C O'Connor, Denton Callander, Marlene Kong, Simon Graham, Dina Saulo, Christopher K Fairley, David G Regan, Andrew Grulich, Nicola Low, Rebecca J Guy, Basil Donovan
OBJECTIVES: To examine the impact of the national human papillomavirus (HPV) vaccination program (available to girls and women [12-26 years] since 2007 and to boys [12-15 years] since 2013) on the number of diagnoses of genital warts in Australian Aboriginal and Torres Strait Islander (Indigenous) people. DESIGN, SETTING, PARTICIPANTS: Analysis of routinely collected data from patients attending 39 sexual health clinics (SHCs) in the Genital Warts Surveillance Network for the first time...
March 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28301611/gtl001-a-bivalent-therapeutic-vaccine-against-human-papillomavirus-16-and-18-induces-antigen-specific-cd8-t-cell-responses-leading-to-tumor-regression
#4
Michaël Esquerré, Myriam Bouillette-Marussig, Anne Goubier, Marie Momot, Christophe Gonindard, Hélène Keller, Astrid Navarro, Marie-Christine Bissery
BACKGROUND: Prophylactic vaccines are available for women and girls not yet infected with HPV, but women already infected with HPV need a treatment to prevent progression to high-grade cervical lesions and cancer. GTL001 is a bivalent therapeutic vaccine for eradicating HPV-infected cells that contains HPV16 E7 and HPV18 E7 both fused to detoxified adenylate cyclase from Bordetella pertussis, which binds specifically to CD11b+ antigen-presenting cells. This study examined the ability of therapeutic vaccination with GTL001 adjuvanted with topical imiquimod cream to induce functional HPV16 E7- and HPV18 E7-specific CD8+ T cell responses...
2017: PloS One
https://www.readbyqxmd.com/read/28295222/traf3-cyld-mutations-identify-a-distinct-subset-of-human-papilloma-virus-associated-head-and-neck-squamous-cell-carcinoma
#5
Michael Hajek, Andrew Sewell, Susan Kaech, Barbara Burtness, Wendell G Yarbrough, Natalia Issaeva
BACKGROUND: The incidence of human papillomavirus (HPV)-associated (HPV-positive) head and neck squamous cell carcinoma (HNSCC) of the oropharynx has dramatically increased over the last decade and continues to rise. Newly diagnosed HPV-positive HNSCCs in the United States currently outnumber any other HPV-associated cancers, including cervical cancer. Despite introduction of the HPV vaccine, the epidemic of HPV-positive HNSCC is expected to continue for approximately 60 years. Compared with patients who have tobacco-associated HNSCC, those who have HPV-positive HNSCC have better overall survival and response to treatment...
March 13, 2017: Cancer
https://www.readbyqxmd.com/read/28294358/prevalence-of-human-papillomavirus-infection-among-chilean-women-from-2012-to-2016
#6
Nicolás Vergara, Gloria Espinoza, Monserrat Balanda, Andrea Quiero, Wilma Hidalgo, Héctor San Martín, Alejandro Ramírez, Eugenio Ramírez
Here we evaluated the prevalence of Human Papillomavirus (HPV) in two groups of Chilean women. The first group consisted of 3,235 women aged 18-64 years attended in six primary care centres of Santiago. The second group consisted of 456 women 18-85 aged who consulted the Gynaecology Department of the Reference Hospital of Santiago. Samples were collected from October 2012 to February 2016. Cervical swabs were analyzed both HPV genotyping by PCR and Reverse Line Blot, and cervical cytology by Pap testing. Results showed a prevalence of 12...
March 11, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28292448/human-papillomavirus-vaccine-update
#7
REVIEW
Diane R Blake, Amy B Middleman
Rates of cancers attributable to human papillomavirus (HPV) are rising. A safe and extremely effective vaccine is available to prevent many of these cancers. Studies have shown that health care providers' recommendation to immunize is the most important factor in parents' decision. Parents of all adolescent boys and girls should receive a strong and unequivocal recommendation to vaccinate their child against HPV at the 11- or 12-year-old well child visit. Ideally, adolescents complete their HPV vaccine series by their 13th birthday, leading to greater immune response and protection before most adolescents are exposed to sexually transmitted HPV...
April 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/28288041/lymph-node-activation-by-pet-ct-following-vaccination-with-licensed-vaccines-for-human-papillomaviruses
#8
Emily E Coates, Pamela J Costner, Martha C Nason, Douglas M Herrin, Shielah Conant, Peter Herscovitch, Uzma N Sarwar, Lasonji Holman, Jillian Mitchell, Galina Yamshchikov, Richard A Koup, Barney S Graham, Corina M Millo, Julie E Ledgerwood
BACKGROUND: While PET using F-FDG is most commonly used for imaging malignant tumors, vaccination is known to cause transient inflammation of lymph nodes inducing positive findings on F-FDG PET scans. The pattern, magnitude, and duration of lymph node activation following vaccination have not been clearly defined. Furthermore, the addition of adjuvants to vaccines can further enhance the immune response. The presented study was designed to define lymph node activation following administration of the Food and Drug Administration-licensed human papillomavirus vaccines, Cervarix and Gardasil, which contain similar antigens with different adjuvants...
March 10, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28286668/a-protocol-for-a-cluster-randomised-feasibility-study-of-an-adolescent-incentive-intervention-to-increase-uptake-of-hpv-vaccination-among-girls
#9
Alice S Forster, Victoria Cornelius, Lauren Rockliffe, Laura A V Marlow, Helen Bedford, Jo Waller
BACKGROUND: Uptake of the human papillomavirus (HPV) vaccine in the UK is good, but there are pockets of the community who remain unprotected. Immunisation teams usually require written parental consent for a girl to receive the vaccine. Evidence suggests that uptake of the vaccine might be improved by promoting consent form return (if returned, forms are likely to grant consent). Incentivising girls to return consent forms is a promising approach to promoting consent form return. Before testing the efficacy of an incentive intervention in a randomised controlled trial (RCT), we must first establish whether the RCT is feasible...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28284227/the-association-between-adverse-pregnancy-outcomes-and-maternal-human-papillomavirus-infection-a-systematic-review-protocol
#10
Joseph Niyibizi, Nadège Zanré, Marie-Hélène Mayrand, Helen Trottier
BACKGROUND: Human papillomavirus (HPV) is the most prevalent genital infection, especially in young women of reproductive age. In vitro and animal model experiments provide compelling evidence of the harmful effect of HPV on pregnancy outcomes, but results from epidemiologic studies are inconclusive. We aim to determine the strength of the relationship between adverse pregnancy outcomes (APO) and HPV infection and assess its consistency across studies, by systematically reviewing the literature...
March 11, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28282648/geospatial-planning-and-the-resulting-economic-impact-of-human-papillomavirus-vaccine-introduction-in-mozambique
#11
Leila A Haidari, Shawn T Brown, Dagna Constenla, Eli Zenkov, Marie Ferguson, Gatien de Broucker, Sachiko Ozawa, Samantha Clark, Allison Portnoy, Bruce Y Lee
BACKGROUND: Research has shown that the distance to the nearest immunization location can ultimately prevent someone from getting immunized. With the introduction of human papillomavirus (HPV) vaccine throughout the world, a major question is whether the target populations can readily access immunization. METHODS: In anticipation of HPV vaccine introduction in Mozambique, a country with a 2015 population of 25,727,911, our team developed Strategic Integrated Geo-temporal Mapping Application) to determine the potential economic impact of HPV immunization...
April 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28282583/control-of-immune-escaped-human-papilloma-virus-is-regained-after-therapeutic-vaccination
#12
REVIEW
Wenbo Ma, Cornelis Jm Melief, Sjoerd H van der Burg
High-risk human papillomaviruses infect the basal cells of human epithelia. There it deploys several mechanisms to suppress pathogen receptor recognition signalling, impeding the immune system to control viral infection. Furthermore, infected cells become more resistant to type I and II interferon, tumour necrosis factor-α and CD40 activation, via interference with downstream programs halting viral replication or regulating the proliferation and cell death. Consequently, some infected individuals fail to raise early protein-specific T-cell responses that are strong enough to protect against virus-induced premalignant disease and ultimately cancer...
March 7, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28281783/who-is-to-blame-framing-hpv-to-influence-vaccination-intentions-among-college-students
#13
McKenzie M Vorpahl, Janet Z Yang
Human papillomavirus (HPV) is a prevalent sexually transmitted infection (STI) among college students. Although previous research has studied HPV-related health communication strategies using various framing techniques, the goal of this study is to test how two unique message frames-whether mentioning HPV as an STI and whether to attribute the cause of infection as external or internal-would influence young adults' intentions to receive the recommended HPV vaccine. Results indicate that gender and causal attribution framing influenced participants' intentions to receive the HPV vaccine...
March 10, 2017: Health Communication
https://www.readbyqxmd.com/read/28279866/the-cost-of-developing-a-computerized-tailored-interactive-multimedia-intervention-vs-a-print-based-photonovella-intervention-for-hpv-vaccine-education
#14
Siddharth S Karanth, David R Lairson, Lara S Savas, Sally W Vernon, María E Fernández
Mobile technology is opening new avenues for healthcare providers to create and implement tailored and personalized health education programs. We estimate and compare the cost of developing an i-Pad based tailored interactive multimedia intervention (TIMI) and a print based (Photonovella) intervention to increase human papillomavirus (HPV) immunization. The development costs of the interventions were calculated using a societal perspective. Direct cost included the cost of planning the study, conducting focus groups, and developing the intervention materials by the research staff...
February 28, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28279264/introduction-of-molecular-hpv-testing-as-the-primary-technology-in-cervical-cancer-screening-acting-on-evidence-to-change-the-current-paradigm
#15
Joseph E Tota, James Bentley, Jennifer Blake, François Coutlée, Máire A Duggan, Alex Ferenczy, Eduardo L Franco, Michael Fung-Kee-Fung, Walter Gotlieb, Marie-Hélène Mayrand, Meg McLachlin, Joan Murphy, Gina Ogilvie, Sam Ratnam
Since being introduced in the 1940s, cervical cytology - despite its limitations - has had unequivocal success in reducing cervical cancer burden in many countries. However, we now know that infection with human papillomavirus (HPV) is a necessary cause of cervical cancer and there is overwhelming evidence from large-scale clinical trials, feasibility studies and real-world experience that supports the introduction of molecular testing for HPV as the primary technology in cervical cancer screening (i.e., "HPV primary screening")...
May 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28278414/surveillance-of-adverse-events-following-immunisation-in-australia-annual-report-2014
#16
Aditi Dey, Han Wang, Helen E Quinn, Richard Hill, Kristine K Macartney
This report summarises Australian passive surveillance data for adverse events following immunisation (AEFI) for 2014 reported to the Therapeutic Goods Administration for 2014 and describes reporting trends over the 15-year period 1 January 2000 to 31 December 2014. There were 3,087 AEFI records for vaccines administered in 2014; an annual AEFI reporting rate of 13.2 per 100,000 population. There was a decline of 5% in the overall AEFI reporting rate in 2014 compared with 2013. This decline in reported adverse events in 2014 compared with the previous year was mainly attributable to fewer reports following the human papillomavirus (HPV) vaccine as it was the 2nd year of the extension of the National HPV Vaccination Program to males...
September 30, 2016: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/28277236/-we-ve-been-together-we-don-t-have-it-we-re-fine-how-relationship-status-impacts-human-papillomavirus-vaccine-behavior-among-young-adult-women
#17
Erika L Thompson, Cheryl A Vamos, Diane M Straub, William M Sappenfield, Ellen M Daley
BACKGROUND: Vaccination against the human papillomavirus (HPV) has the potential to significantly reduce morbidity and mortality associated with genital warts and HPV-related cancers. However, HPV vaccination rates continue to be suboptimal among the "catch-up" population of 18- to 26-year-old women. One consistent risk factor for nonvaccination is being in a relationship. This study aimed to understand how relationship status and vaccination status impact risk perceptions and perceived need for the HPV vaccine among young adult women...
October 27, 2016: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28277144/molecular-tests-potentially-improving-hpv-screening-and-genotyping-for-cervical-cancer-prevention
#18
Ana Gradíssimo, Robert D Burk
Human papillomavirus (HPV)-related cancers can be averted by type-specific vaccination (primary prevention) and/or through detection and ablation of precancerous cervical lesions (secondary prevention). This review presents current challenges to cervical cancer screening programs, focusing on recent molecular advances in HPV testing and potential improvements on risk stratification. Areas covered: High-risk (HR)-HPV DNA detection has been progressively incorporated into cervix cancer prevention programs based on its increased sensitivity...
February 20, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28276945/using-community-engagement-to-develop-a-web-based-intervention-for-latinos-about-the-hpv-vaccine
#19
Julie A Maertens, Andrea M Jimenez-Zambrano, Karen Albright, Amanda F Dempsey
Human papillomavirus (HPV) infection is pervasive among sexually active women and men, and Hispanic women are at particularly high risk as they have higher rates of invasive cervical cancer compared to other racial or ethnic groups in the United States. There is a need for interventions to increase HPV vaccination among this high-risk population. This study investigated how to modify a previously developed web-based intervention that provided individually tailored information about HPV to improve its use among the Latino population...
February 22, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28276149/is-extending-screening-intervals-safe-in-hpv-negative-women
#20
Henry Kitchener
Greater sensitivity which lowers cancer incidence (Rocco et al, Lancet 2014), extended screening intervals, and prophylactic vaccination provide the rationale for high risk human papillomavirus (HR-HPV) testing to replace cytology as the primary test in cervical screening programmes both in the UK and internationally. Zorzi et al report in the BJOG, a timely cohort study from Italy of primary HPV cervical screening, concluding that following primary HPV screening, three years is too soon for a repeat screening round...
March 9, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
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