keyword
https://read.qxmd.com/read/38178771/-clinical-and-pathological-characteristics-and-prognosis-analysis-of-gray-zone-lymphoma
#1
JOURNAL ARTICLE
S Z Liu, X P Zong, W Z Cai, H J He, Z X Ma, J Q Li, C X Li, D P Wu
To explore the clinical and pathological characteristics as well as therapies and prognosis of gray zone lymphoma (GZL). The clinical data of 10 GZL patients admitted to the First Affiliated Hospital of Soochow University from December 2016 to December 2022 were retrospectively collected. The clinical and pathological characteristics, therapies and prognosis were analyzed. The cut-off time for follow-up visits was December 31, 2022, and the median time for follow-up visits [ M ( Q 1 , Q 3 )] was 40.0 (28.3, 59...
January 2, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38132216/machine-learning-radiomics-signature-for-differentiating-lymphoma-versus-benign-splenomegaly-on-ct
#2
JOURNAL ARTICLE
Jih-An Cheng, Yu-Chun Lin, Yenpo Lin, Ren-Chin Wu, Hsin-Ying Lu, Lan-Yan Yang, Hsin-Ju Chiang, Yu-Hsiang Juan, Ying-Chieh Lai, Gigin Lin
BACKGROUND: We aimed to develop and validate a preoperative CT-based radiomics signature for differentiating lymphoma versus benign splenomegaly. METHODS: We retrospectively analyzed CT studies from 139 patients (age range 26-93 years, 43% female) between 2011 and 2019 with histopathological diagnosis of the spleen (19 lymphoma, 120 benign) and divided them into developing ( n = 79) and testing ( n = 60) datasets. The volumetric radiomic features were extracted from manual segmentation of the whole spleen on venous-phase CT imaging using PyRadiomics package...
December 8, 2023: Diagnostics
https://read.qxmd.com/read/38098799/stiff-person-syndrome-revealing-an-occult-gray-zone-lymphoma-a-diagnostic-challenge
#3
Mohammad Sadegh Fakhari, Leila Poorsaadat, Hooman Mohammad Talebi, Farid Kosari
KEY CLINICAL MESSAGE: Stiff-Person Syndrome (SPS) can be associated with various malignancies, including lymphomas. Therefore, clinicians should always remain vigilant for the presence of an underlying malignancy, especially in older patients presenting with SPS. ABSTRACT: Stiff-person syndrome (SPS) is a rare neurological disorder characterized by painful muscle spasms. It can occur as a paraneoplastic syndrome associated with various malignancies. We present a case of an older male adult with a history of recurrent fever episodes and elevated inflammatory markers for 1 year who subsequently developed neurological symptoms...
December 2023: Clinical Case Reports
https://read.qxmd.com/read/38024596/the-pathobiology-of-select-adolescent-young-adult-lymphomas
#4
REVIEW
Christian Steidl, Robert Kridel, Michael Binkley, Lindsay M Morton, Amy Chadburn
Lymphoid cancers are among the most frequent cancers diagnosed in adolescents and young adults (AYA), ranging from approximately 30%-35% of cancer diagnoses in adolescent patients (age 10-19) to approximately 10% in patients aged 30-39 years. Moreover, the specific distribution of lymphoid cancer types varies by age with substantial shifts in the subtype distributions between pediatric, AYA, adult, and older adult patients. Currently, biology studies specific to AYA lymphomas are rare and therefore insight into age-related pathogenesis is incomplete...
November 2023: EJHaem
https://read.qxmd.com/read/37915147/primary-mediastinal-gray-zone-lymphoma-in-an-immunocompetent-young-adult
#5
JOURNAL ARTICLE
Aisyah Wirdah, Yenny Dian Andayani, Mediarty Syahrir, Norman Djamaludin, Krisna Murti, Ali Zainal Abidin
A 28 -year-old man presented to our hospital with a rapidly growing nodule in the left cervical and bilateral axilla with a history of loss of weight. He has been experiencing a nodule in her right cervical since two years ago and had done FNAC and diagnosed extrapulmonary tuberculosis (EPTB), on Examination at left cervical colli; mass size 9cm x 7 cm, mobile, Lymphadenopathy at pre auricular size 3cm x 3cm, lymphadenopathy supraclavicular size 1cm x 0,5 cm. bilateral lymphadenopathy Axila size 4cmx 4cmx 2xcm mobile...
July 2023: Acta Medica Indonesiana
https://read.qxmd.com/read/37884676/immunoglobulin-light-chain-transcript-detection-by-ultrasensitive-rna-in-situ-hybridization-for-b-cell-lymphoma-diagnosis
#6
JOURNAL ARTICLE
Luisa Lorenzi, Silvia Lonardi, Michela Bonezzi, Stefania Zini, Mattia Bugatti, Arianna Valzelli, Flavia Melotti, Mattia Facchetti, Iacopo Ghini, Vincenzo Villanacci, Piera Balzarini, Marco Pizzi, Viviana Giustini, Anna Galvagni, Marco Chiarini, Angelo Paolo Dei Tos, William Vermi, Stefano Casola, Fabio Facchetti
Evaluation of B-cell clonality can be challenging in the interpretation of lymphoid infiltrates on tissue sections. Clonality testing based on IG gene rearrangements analysis by PCR (IG-PCR) is the gold standard. Alternatively, B-cell clonality can be assessed by the recognition of immunoglobulin light chain (IgLC) restriction, by immunohistochemistry (IHC), chromogenic in situ hybridization (ISH) or flow cytometry (FC). IG-PCR requires molecular facilities, and FC requires cell suspensions, both not widely available in routine pathology units...
October 26, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37792483/anti-ma2-antibody-mediated-paraneoplastic-cerebellar-degeneration-and-myeloneuropathy-secondary-to-lymphoma
#7
JOURNAL ARTICLE
Armin Handzic, Natalie Brossard-Barbosa, Daniel Mandell, Si Kei Lou, Edward Margolin
A 61-year-old woman with a history of untreated low-grade B-cell lymphoma presented with blurry vision, unsteadiness, and worsening pain on touching skin of the upper trunk was enrolled. Blurry vision was attributed to oscillopsia from downbeat nystagmus, which later evolved into macrosaccadic oscillations. MRI brain and spine showed mild, longitudinally extensive T2 hyperintensity in the central gray matter of the spinal cord extending from the medulla to T11 level. Serum paraneoplastic panel was negative; however, she had very high titers of anti-Ma2 antibodies in cerebrospinal fluid...
October 4, 2023: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://read.qxmd.com/read/37785532/the-role-of-radiation-therapy-in-the-management-of-gray-zone-lymphoma
#8
JOURNAL ARTICLE
O Saifi, W G Rule, S C Lester, N N Laack, W Breen, A Rosenthal, S M Ansell, T M Habermann, J Villasboas Bisneto, M Iqbal, M Alhaj Moustafa, H Tun, M Kharfan-Dabaja, J L Peterson, B S Hoppe
PURPOSE/OBJECTIVE(S): Gray zone lymphoma (GZL) is a relatively rare disease predominantly affecting young adults with purportedly poor outcomes with current treatment approaches. The role of radiation therapy (RT) in the management of GZL is not well established. This is the largest study to report on the outcomes of GZL patients treated with and without RT. MATERIALS/METHODS: A retrospective review of 30 patients with GZL treated across 3 institutions from 2009 to 2021 was performed...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/37706509/very-low-dose-radiotherapy-for-extranodal-marginal-zone-lymphoma-of-bronchus-associated-lymphoid-tissue
#9
JOURNAL ARTICLE
Morgan E Freret, Kathryn R Tringale, Lillian Boe, Brandon S Imber, Erel Joffe, Joachim Yahalom, Carla Hajj
Extranodal marginal zone lymphoma of bronchus-associated lymphoid tissue (BALT) is a rare cancer for which optimal treatment strategies are undefined. Retrospective analyses suggest excellent outcomes with surgical resection for localized BALT lymphoma; however, the role of radiotherapy remains underexplored. We report the largest-to-date single-center analysis of 13 primary BALT lymphoma patients treated with radiotherapy. Of 15 treated lesions, we report a 100% response rate with complete response (CR) achieved in 67% of lesions...
September 14, 2023: Leukemia & Lymphoma
https://read.qxmd.com/read/37530791/mediastinal-large-b-cell-lymphoma-and-surrounding-gray-areas-a-report-of-the-lymphoma-workshop-of-the-20th-meeting-of-the-european-association-for-haematopathology
#10
REVIEW
Sarah E Gibson, Stefan Dojcinov, Snjezana Dotlic, Sylvia Hartmann, Eric D Hsi, Monika Klimkowska, Federica Melle, Stefano A Pileri, Colleen A Ramsower, Karen Rech, Lisa M Rimsza, Socorro Maria Rodriguez-Pinilla, Thomas A Tousseyn, Daphne de Jong, Elena Sabattini
Session 3 of the 2021 European Association for Haematopathology/Society for Hematopathology Workshop focused on mediastinal large B cell lymphomas and surrounding gray areas. One half of the session was dedicated to primary mediastinal large B cell lymphoma (PMBL) and included cases with classic clinicopathologic features, as well as cases with either morphologic or immunophenotypic variation, and PMBL-like cases with primary extramediastinal disease. The role of additional immunophenotyping and/or molecular testing to aid in the diagnosis of PMBL was discussed...
August 2, 2023: Virchows Archiv: An International Journal of Pathology
https://read.qxmd.com/read/37356987/-gray-zone-lymphoma-five-cases-report-and-literature-review
#11
REVIEW
H S Zou, H J Zhang, H M Liu, W Y Huang, W Liu, R Lyu, T Y Wang, W W Sui, M W Fu, Q Wang, L G Qiu, D H Zou
Objective: To investigate the clinical and pathological features, treatment, and prognosis of gray zone lymphoma (GZL) . Methods: From July 2, 2013, to February 10, 2021, the clinical and pathological features, treatment, and outcomes of five patients with GZL at the Blood Diseases Hospital, Chinese Academy of Medical Sciences were studied retrospectively. Results: There were one male and 4 females, with a median age of 28 (16-51) years at diagnosis. Four patients had mediastinal (thymic) involvement, two of which had superior vena cava obstruction syndrome, and 3 patients had extra-nodal involvement...
March 14, 2023: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://read.qxmd.com/read/37287497/gray-zone-lymphoma-a-case-report-and-comprehensive-review-of-literature
#12
REVIEW
Dariusz Uczkowski, Hamza Ashraf, Mohamad Cherry, Nikolay Dimov
Gray zone lymphoma is a very rare liquid malignancy that possesses intersecting features between primary mediastinal B-cell lymphoma and classic Hodgkin Lymphoma. In the case presented and accompanying literature review, we will discuss a patient with a chief complaint of shortness of breath and was found to have a mediastinal mass with biopsy consistent with mediastinal gray zone lymphoma. Herein, we explore the historical and recently updated diagnostic criteria of gray zone lymphoma from 2022 as well as the pathophysiology as it pertains to gene expression, while also reviewing the histological findings, epidemiology and treatment modalities...
2023: Leukemia Research Reports
https://read.qxmd.com/read/37261857/targeted-therapy-in-mediastinal-gray-zone-lymphoma
#13
EDITORIAL
John Kuruvilla
No abstract text is available yet for this article.
June 1, 2023: Blood
https://read.qxmd.com/read/37259152/mediastinal-gray-zone-lymphoma-in-a-pregnant-woman-presenting-with-cardiac-tamponade
#14
JOURNAL ARTICLE
Azin Alizadehasl, Kamran Roudini, Mahshid Hesami, Farid Kosari, Hamid Reza Pouraliakbar, Mina Mohseni, Negar Dokhani
BACKGROUND: Mediastinal gray zone lymphoma is a newly recognized rare B cell neoplasm, which is challenging in diagnosis and treatment. CASE PRESENTATION: In the current study, we aimed to report a 25-year-old pregnant woman at 25 weeks of gestation who presented with chronic cough and progressive shortness of breath, hypotension, tachycardia, and tachypnea. A large circumferential pericardial effusion with compressive effect on the right atrium and right ventricle and a large extracardiac mass with external pressure to mediastinal structures were seen on trans thoracic echocardiography...
May 31, 2023: Cardio-Oncology
https://read.qxmd.com/read/37254478/pediatric-gray-zone-lymphoma-according-to-the-2022-who-classification-an-italian-cohort-study
#15
JOURNAL ARTICLE
Giulia Angela Restivo, Piero Farruggia, Marta Pillon, Maurizio Mascarin, Caterina Elia, Santina Recupero, Paola Muggeo, Celeste Cagnazzo, Daniela Onofrillo, Rosamaria Mura, Ilaria Furfari, Angela Trizzino, Patrizia Bertolini, Alessandra Sala, Raffaela De Santis, Daniela Galimberti, Elisabetta Schiavello, Elisa Carraro
BACKGROUND: The 2022 World Health Organization (WHO) classification redefines the concept of gray zone lymphoma (GZL), restricting it in practice to cases of mediastinal/thymic origin (mediastinal gray zone lymphoma, MGZL) with overlapping features between primary mediastinal B-cell lymphoma (PMBCL) and classical Hodgkin lymphoma (CHL). Cases with histological characteristics of GZL but occurring without mediastinal involvement are better classified as diffuse large B-cell lymphoma, not otherwise specified (DLBCL NOS), with few exceptions...
May 30, 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/37218320/-%C3%A2-recent-advances-in-mediastinal-gray-zone-lymphoma
#16
JOURNAL ARTICLE
Nobuhiko Yamauchi, Dai Maruyama
No abstract text is available yet for this article.
May 2023: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://read.qxmd.com/read/37195392/thinking-outside-the-box-in-mediastinal-lymphoma-management
#17
JOURNAL ARTICLE
Marwa Alhamss, Riad El Fakih
No abstract text is available yet for this article.
May 17, 2023: Clinical hematology international
https://read.qxmd.com/read/37183912/brentuximab-vedotin-plus-avd-followed-by-involved-node-radiotherapy-in-a-patient-with-classic-hodgkin-lymphoma-following-gray-zone-lymphoma-after-autologous-stem-cell-transplantation-failure
#18
JOURNAL ARTICLE
Norihiro Ueda, Harumi Kato, Seiichi Kato, Toko Saito, Hiroyuki Tachibana, Masamitsu Yanada, Hirofumi Taji, Takeshi Kodaira, Waki Hosoda, Kazuhito Yamamoto
BACKGROUND: No consensus has been reached yet concerning treatment strategies for a sequential classic Hodgkin lymphoma (CHL) following gray zone lymphoma (GZL). Prognosis of GZL after a failed autologous hematopoietic stem-cell transplantation (auto-HCT) is poor and treatment strategy is very limited. As yet there are limited data showing clinical outcomes of brentuximab vedotin (BV) for GZL, especially for sequential CHL after GZL. CASE PRESENTATION: We report a case of CHL following primary refractory GZL after a failed auto-HCT and showed favorable response to first-line CHL-directed chemoradiotherapy consisting of BV plus doxorubicin, vinblastine, and dacarbazin (AVD) followed by irradiation...
December 2023: Hematology (Amsterdam, Netherlands)
https://read.qxmd.com/read/37153303/internal-jugular-venous-thrombosis-with-superior-vena-cava-syndrome-a-rare-first-presentation-of-gray-zone-lymphoma
#19
Prabasha Weeraddana, Nisha Nepal, Mohammed Saleh, Fnu Sandeep, Niwanthi Weerasooriya, Mehndi Dandwani, Eric Ma
Gray zone lymphoma (GZL) is defined as a B-cell lymphoma with intermediate features between both diffuse large B-cell lymphoma (DLBCL) and classical Hodgkin lymphoma (CHL). GZL is an aggressive disease, which in addition to the B-symptoms, can present as shortness of breath and neck swelling from underlying superior vena cava (SVC) syndrome. Thrombosis of the internal jugular vein (IJVT) is rare and usually associated with head and neck infection, intravenous (IV) drug abuse, and central venous catheter placement...
April 2023: Curēus
https://read.qxmd.com/read/37149361/hodgkin-lymphoma-and-its-differential-diagnosis-new-twists-on-an-old-challenge
#20
REVIEW
Aliyah R Sohani
Hodgkin lymphoma is a B-cell neoplasm that typically presents with localized, nodal disease. Tissues are characterized by few large neoplastic cells, usually comprising less than 10% of tissue cellularity, present in a background of abundant nonneoplastic inflammatory cells. This inflammatory microenvironment, although key to the pathogenesis, can make diagnosis a challenge because reactive conditions, lymphoproliferative diseases, and other lymphoid neoplasms may mimic Hodgkin lymphoma and vice versa. This review provides an overview of the classification of Hodgkin lymphoma, its differential diagnosis, including emerging and recently recognized entities, and strategies to resolve challenging dilemmas and avoid diagnostic pitfalls...
June 2023: Surgical Pathology Clinics
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