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Gray zone lymphoma

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https://www.readbyqxmd.com/read/27888879/gray-zone-lymphoma-current-diagnosis-and-treatment-options
#1
REVIEW
Monika Pilichowska, Athena Kritharis, Andrew M Evens
The morphology of gray zone lymphoma (GZL) is variable with tumor cells spanning the spectrum of diffuse large B-cell lymphoma (DLBCL) and classical Hodgkin lymphoma. The immunophenotype is frequently discordant. Clinically, the initial case descriptions of GZL were primarily with mediastinal presentation; however, a nonmediastinal (systemic) clinical subtype is now recognized. Patients with GZL have high relapse rates. Recommended treatment of GZL is with a DLBCL-directed regimen with consideration for consolidative radiotherapy for bulk disease...
December 2016: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/27888658/a-case-of-composite-classical-and-nodular-lymphocyte-predominant-hodgkin-lymphoma-with-progression-to-diffuse-large-b-cell-non-hodgkin-lymphoma-diagnostic-difficulty-in-fine-needle-aspiration-cytology
#2
Dilip K Das, Zafar A Sheikh, Mariam H Al-Shama'a, Bency John, Abdulla M S Alawi, Thamradeen A Junaid
A small percentage of nodular lymphocytic predominant Hodgkin lymphoma (NLPHL) progresses to diffuse large B-cell lymphoma (DLBCL). There have also been rare reports of gray zone lymphoma with features intermediate between classical Hodgkin lymphoma (CHL) and DLBCL. We report a very rare case of composite lymphoma (CHL and NLPHL) progressing to DLBCL, and highlight the diagnostic difficulty faced during its fine-needle aspiration (FNA) cytology diagnosis. A 65-year-old woman presented with a right axillary swelling which was subjected to FNA cytology...
November 26, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27623181/mediastinal-gray-zone-lymphoma-with-features-intermediate-between-classical-hodgkin-lymphoma-and-primary-mediastinal-b-cell-lymphoma
#3
Haa-Na Song, Seok Jin Kim, Young Hyeh Ko, Won Seog Kim
BACKGROUND: Mediastinal gray zone lymphoma (MGZL) shares clinical characteristics with primary mediastinal B-cell lymphoma (PMBCL) and nodular sclerosing Hodgkin lymphoma (NSHL). However, MGZL is extremely rare, and an appropriate treatment for it has not yet been established. METHODS: We retrospectively analyzed 8 patients who were treated with systemic chemotherapy for MGZL between 2007 and 2014. RESULTS: The patients with MGZL were predominantly young and male (median age 26 years), and 62...
2016: Acta Haematologica
https://www.readbyqxmd.com/read/27431084/-mediastinal-gray-zone-lymphoma-a-case-report-and-literature-review
#4
J F Zhu, G Y Gao, W Q Zeng, Q Li, Z D Wu, W Xu, J Y Li
No abstract text is available yet for this article.
June 14, 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/27419920/the-immunophenotypic-spectrum-of-primary-mediastinal-large-b-cell-lymphoma-reveals-prognostic-biomarkers-associated-with-outcome
#5
Jacob R Bledsoe, Robert A Redd, Robert P Hasserjian, Jacob D Soumerai, Ha T Nishino, Daniel F Boyer, Judith A Ferry, Lawrence R Zukerberg, Nancy Lee Harris, Jeremy S Abramson, Aliyah R Sohani
Primary mediastinal large B-cell lymphoma (PMBL) is a distinct subtype of diffuse large B-cell lymphoma (DLBCL) that shows overlap with classical Hodgkin lymphoma (CHL) and a favorable prognosis compared to mediastinal gray-zone lymphoma (MGZL). We performed immunohistochemistry on initial diagnostic specimens of 49 cases of uniformly treated PMBL to determine the frequency and clinical significance of expression of antigens commonly seen in CHL and MGZL, along with markers previously shown to be prognostic in DLBCL, not otherwise specified...
October 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27312795/recurrent-mutations-of-the-exportin-1-gene-xpo1-and-their-impact-on-selective-inhibitor-of-nuclear-export-compounds-sensitivity-in-primary-mediastinal-b-cell-lymphoma
#6
Fabrice Jardin, Anais Pujals, Laura Pelletier, Elodie Bohers, Vincent Camus, Sylvain Mareschal, Sydney Dubois, Brigitte Sola, Marlène Ochmann, François Lemonnier, Pierre-Julien Viailly, Philippe Bertrand, Catherine Maingonnat, Alexandra Traverse-Glehen, Philippe Gaulard, Diane Damotte, Richard Delarue, Corinne Haioun, Christian Argueta, Yosef Landesman, Gilles Salles, Jean-Philippe Jais, Martin Figeac, Christiane Copie-Bergman, Thierry Jo Molina, Jean Michel Picquenot, Marie Cornic, Thierry Fest, Noel Milpied, Emilie Lemasle, Aspasia Stamatoullas, Peter Moeller, Martin J S Dyer, Christer Sundstrom, Christian Bastard, Hervé Tilly, Karen Leroy
Primary mediastinal B-cell lymphoma (PMBL) is an entity of B-cell lymphoma distinct from the other molecular subtypes of diffuse large B-cell lymphoma (DLBCL). We investigated the prevalence, specificity, and clinical relevance of mutations of XPO1, which encodes a member of the karyopherin-β nuclear transporters, in a large cohort of PMBL. PMBL cases defined histologically or by gene expression profiling (GEP) were sequenced and the XPO1 mutational status was correlated to genetic and clinical characteristics...
September 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27265795/non-hodgkin-s-lymphoma-with-bone-involvement-a-single-center-experience-with-18-patients
#7
Filiz Vural, Nur Akad Soyer, Pınar Özen, Ayhan Dönmez, Serkan Ocakçı, Güray Saydam, Seçkin Çağırgan, Murat Tombuloğlu
OBJECTIVE: Non-Hodgkin's lymphoma (NHL) of bone is a rare entity. The most common histological subtype is diffuse large B cell lymphoma (DLBCL). The major presenting symptoms are soft tissue swelling, bone pain and pathological fracture. Treatment options are chemotherapy, radiotherapy, surgery, or a combination of these modalities. METHODS: We retrospectively analyzed the 18 patients (11 females, 7 males) with NHL of bone who were diagnosed and treated between 1995-2005...
March 5, 2010: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/27263619/gastric-and-non-gastric-marginal-zone-b-cell-lymphoma-of-mucosa-associated-lymphoid-tissue-a-single-center-experience
#8
Filiz Vural, Serkan Ocakcı, Senem Dubova, Nur Akad Soyer, Güray Saydam, Seçkin Çağırgan, Yavuz Anacak, Mine Hekimgil, Ayhan Dönmez, Murat Tombuloğlu
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) is a distinct lymphoma with specific clinical and pathological features that occurs in diverse anatomic locations. We conducted this retrospective study to demonstrate our experience in patients with MALT lymphomas and compare our results with the literature. We studied 23 patients with histologically confirmed diagnosis of MALT lymphomas (12 with gastric, 11 with non-gastric localization) treated during the past 13 years. The female/male ratio of patients was 15/8 with a median age at presentation of 56 years (range 27-88 years)...
June 5, 2007: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/27164737/mediastinal-gray-zone-lymphoma
#9
Mukesh Bhardwaj, Rajat Saha, Deepti Shuklia Misra, Veena Malhotra
A 50-year-old male presented with cough and breathlessness. A positron emissoin tomography scan revealed FDG (Fluorodeoxyglucose) avid mediastinal mass. Tru-cut biopsy showed fibrotic stromal tissue with cellular infiltrate consisting of abnormal lymphoid cells and few large cells with smudged nucleus. Immunohistochemistry revealed diffuse positivity with CD20, focal positivity for CD30 and rare CD15 positive cells. Histological picture and immune profile showed overlaping features of non-Hodgkin's as well as Hodgkin's lymphoma...
October 2015: Indian Journal of Chest Diseases & Allied Sciences
https://www.readbyqxmd.com/read/27093913/ebv-positive-diffuse-large-b-cell-lymphoma-of-the-elderly-2016-update-on-diagnosis-risk-stratification-and-management
#10
REVIEW
Jorge J Castillo, Brady E Beltran, Roberto N Miranda, Ken H Young, Julio C Chavez, Eduardo M Sotomayor
Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) of the elderly is a provisional entity included in the 2008 WHO classification of lymphoid neoplasms. It is a disease typically seen in the elderly and thought to be associated with chronic EBV infection and severe immunosuppression with a component of immunosenescence. Recent research, however, has suggested that EBV-positive DLBCL can be seen in younger, immunocompetent patients. The diagnosis of EBV-positive DLBCL of the elderly is made through a careful pathological evaluation...
May 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27045512/evaluation-of-the-diagnostic-and-prognostic-value-of-pdl1-expression-in-hodgkin-and-b-cell-lymphomas
#11
Thomas Menter, Andrea Bodmer-Haecki, Stephan Dirnhofer, Alexandar Tzankov
Activation of the programmed death 1 (PD1)/PD1 ligand (PDL1) pathway is important for tumor cells to escape from immune control. The clinical efficacy of therapeutic modulation of the PD1-PDL1 pathway has been recently shown in classical Hodgkin lymphoma (cHL), but little is known about the frequency and diagnostic and prognostic importance of PDL1 expression in lymphomas. The available anti-PDL1 antibody clones E1L3N and SP142 were compared, and a large cohort of Hodgkin lymphomas (n=280) and B-cell lymphomas (n=619) was examined for PDL1 using E1L3N...
August 2016: Human Pathology
https://www.readbyqxmd.com/read/26957476/mediastinal-gray-zone-lymphoma-a-wider-category-than-we-think
#12
Anuj Verma, Tanuja Shet, Sridhar Epari, Manjudevi Gupta, Sumeet Gujral, Nehal Khanna, Siddhartha Laskar, Manju Sengar, Brijesh Arora, Hari Menon, Shripad Banavali
AIM: To identify aggressively behaving classical Hodgkin lymphoma (CHL) of mediastinum and primary mediastinal B-cell lymphoma (PMBCL) and to classify them as mediastinal gray zone lymphoma(MGZL) and to define a minimum immunopanel for the diagnosis of MGZL. MATERIALS AND METHODS: Ninety-two mediastinal B-cell lymphomas were reviewed with a wide immunopanel and were classified as CHL, PMBCL, or MGZL. CHL with an expression of 3 or 4 transcription factors performed worse, and hence the CHL with ≥3 transcription factors were classified as MGZL-CHL...
August 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26742206/difficult-diagnosis-between-b-cell-lymphoma-and-classical-hodgkin-s-lymphoma
#13
REVIEW
Yaixa Rentas Torres, Joshua L Rodríguez-López, Maria Valentin, Hector Silva
Although primary mediastinal large B-cell lymphoma and classic Hodgkin lymphoma of nodular sclerosis type are distinct disease, they share several clinical characteristics and biologic features. However, there are mediastinal lymphomas that not fit in either category. These types of lymphomas are recognized as mediastinal gray zone lymphomas. Gray zone lymphomas are lymphatic tumors that cannot be assigned to a defined lymphoma entity due to morphological, clinical, or genetic reasons. In this report, we present a case of a 22 year-old-Hispanic-female diagnosed with B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Hodgkin lymphoma...
July 2015: Boletín de la Asociación Médica de Puerto Rico
https://www.readbyqxmd.com/read/26464726/the-t-14-18-q32-q21-with-extra-myc-signal-is-it-a-gray-zone-lymphoma
#14
Qin A Chang, Abdulraheem Qasem, Sheshadri Madhusudhana, Alexey Glazyrin
Double-hit lymphomas (DHL) are defined as B-cell lymphoma with a chromosomal breakpoint affecting the MYC/8q24 locus in combination with rearrangement at (14;18)(q32;q21). We recently observed three cases of B-cell lymphoma with an extra intact MYC signal in association with the t(14;18)(q32;q21) translocation. The impact of an extra copy of MYC to the clinical course and prognosis of one patient with Diffuse Large B Cell Lymphoma (DLBCL) and two patients with Follicular Lymphoma (FL) was evaluated. Flow cytometry in all cases demonstrated lambda- or kappa-light chain restricted CD20 and CD10 positive neoplastic B cells...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/26447896/distinguishing-classical-hodgkin-lymphoma-gray-zone-lymphoma-and-large-b-cell-lymphoma-a-proposed-scoring-system
#15
Dennis P O'Malley, Yuri Fedoriw, Lawrence M Weiss
BACKGROUND: The diagnosis of "B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma" represents an indeterminate or equivocal decision in relation to management because there remain differences in the management of Hodgkin and non-Hodgkin lymphomas. We developed a scoring system for this group of lymphomas using markers that are traditionally associated with diagnosis of classical Hodgkin lymphoma (CHL) and immunophenotypic markers associated with the "B-cell program" expressed in normal B cells...
September 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/26380128/b-cell-lymphoma-unclassifiable-transformed-from-follicular-lymphoma-a-rare-presentation-with-review-of-the-literature
#16
Anila Kanna, Swati Agrawal, Kumar Jayant, Varun Kumar Pala, Mohammad Altujjar, Tarik Hadid, Muhammad Khurram
B cell lymphoma, unclassifiable, with features of diffuse large B cell lymphoma and classical Hodgkin's lymphoma (BCLu-DLBCL/CHL) is more commonly known as gray zone lymphoma. These cases more often present with mediastinal disease. In this report, we present a very rare case of BCLu-DLBCL/CHL without mediastinal involvement, transformed from follicular lymphoma (FL) to BCLu-DLBCL/CHL. This patient initially presented with a mass in the right neck; biopsy of the lymph node showed predominantly nodular, follicular pattern...
2015: Case Reports in Hematology
https://www.readbyqxmd.com/read/26135560/identification-of-primary-mediastinal-large-b-cell-lymphoma-at-nonmediastinal-sites-by-gene-expression-profiling
#17
Ji Yuan, George Wright, Andreas Rosenwald, Christian Steidl, Randy D Gascoyne, Joseph M Connors, Anja Mottok, Dennis D Weisenburger, Timothy C Greiner, Kai Fu, Lynette Smith, Lisa M Rimsza, Elaine S Jaffe, Elias Campo, Antonio Martinez, Jan Delabie, Rita M Braziel, James R Cook, German Ott, Julie M Vose, Louis M Staudt, Wing C Chan
Mediastinal involvement is considered essential for the diagnosis of primary mediastinal large B-cell lymphoma (PMBL). However, we have observed cases of diffuse large B-cell lymphoma (DLBCL) with features of PMBL but without detectable mediastinal involvement. The goal was to assess our previously established gene expression profiling (GEP) signature for PMBL in classifying these cases. In a large series of DLBCL cases, we identified 24 cases with a GEP signature of PMBL, including 9 cases with a submission diagnosis of DLBCL consistent with PMBL (G-PMBL-P) and 15 cases with a submission diagnosis of DLBCL...
October 2015: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26044261/gray-zone-lymphoma-with-features-intermediate-between-classical-hodgkin-lymphoma-and-diffuse-large-b-cell-lymphoma-characteristics-outcomes-and-prognostication-among-a-large-multicenter-cohort
#18
MULTICENTER STUDY
Andrew M Evens, Jennifer A Kanakry, Laurie H Sehn, Athena Kritharis, Tatyana Feldman, Aimee Kroll, Randy D Gascoyne, Jeremy S Abramson, Adam M Petrich, Francisco J Hernandez-Ilizaliturri, Zeina Al-Mansour, Camille Adeimy, Jessica Hemminger, Nancy L Bartlett, Anthony Mato, Paolo F Caimi, Ranjana H Advani, Andreas K Klein, Chadi Nabhan, Sonali M Smith, Jesus C Fabregas, Izidore S Lossos, Oliver W Press, Timothy S Fenske, Jonathan W Friedberg, Julie M Vose, Kristie A Blum
Gray zone lymphoma (GZL) with features between classical Hodgkin lymphoma and diffuse large B-cell lymphoma (DLBCL) is a recently recognized entity reported to present primarily with mediastinal disease (MGZL). We examined detailed clinical features, outcomes, and prognostic factors among 112 GZL patients recently treated across 19 North American centers. Forty-three percent of patients presented with MGZL, whereas 57% had non-MGZL (NMGZL). NMGZL patients were older (50 versus 37 years, P = 0.0001); more often had bone marrow involvement (19% versus 0%, P = 0...
September 2015: American Journal of Hematology
https://www.readbyqxmd.com/read/25999451/ebv-positive-large-b-cell-lymphomas-in-young-patients-a-nodal-lymphoma-with-evidence-for-a-tolerogenic-immune-environment
#19
Alina Nicolae, Stefania Pittaluga, Shahed Abdullah, Seth M Steinberg, Thu Anh Pham, Theresa Davies-Hill, Liqiang Xi, Mark Raffeld, Elaine S Jaffe
Few studies have reported Epstein-Barr virus-positive (EBV(+)) large B-cell lymphomas (LBCLs) in young patients without immunodeficiency. We identified 46 such cases in patients ≤45 years of age and analyzed the clinical and pathological characteristics. EBV(+) LBCLs affected predominantly males (male:female = 3.6:1), with a median age of 23 years (range, 4-45 years). All patients presented with lymphadenopathy and 11% also had extranodal disease. Morphologically, 3 patterns were identified: T-cell/histiocyte-rich large B-cell lymphoma-like (n = 36), gray zone lymphoma (n = 7), and diffuse LBCL-not otherwise specified (n = 3)...
August 13, 2015: Blood
https://www.readbyqxmd.com/read/25573987/brentuximab-vedotin-demonstrates-objective-responses-in-a-phase-2-study-of-relapsed-refractory-dlbcl-with-variable-cd30-expression
#20
MULTICENTER STUDY
Eric D Jacobsen, Jeff P Sharman, Yasuhiro Oki, Ranjana H Advani, Jane N Winter, Celeste M Bello, Gary Spitzer, Maria Corinna Palanca-Wessels, Dana A Kennedy, Pamela Levine, Jing Yang, Nancy L Bartlett
Several non-Hodgkin lymphoma (NHL) subtypes, including diffuse large B-cell lymphoma (DLBCL), variably express CD30. This phase 2, open-label study evaluated the efficacy of brentuximab vedotin, an anti-CD30 antibody-drug conjugate, in relapsed/refractory CD30(+) NHL. This planned subset analysis of B-cell NHLs includes 49 patients with DLBCL and 19 with other B-cell NHLs. Objective response rate was 44% for DLBCL, including 8 (17%) complete remissions (CRs) with a median duration of 16.6 months thus far (range, 2...
February 26, 2015: Blood
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