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Choua Thao, Amir Lagstein, Tadashi Allen, Huseyin Erhan Dincer, Hyun Joo Kim
Respiratory involvement in Crohn's disease (CD) is a rare manifestation known to involve the large and small airways, lung parenchyma, and pleura. The clinical presentation is nonspecific, and diagnostic tests can mimic other pulmonary diseases, posing a diagnostic challenge and delay in treatment. We report a case of a 60-year-old female with a history of CD and psoriatic arthritis who presented with dyspnea, fever, and cough with abnormal radiological findings. Diagnostic testing revealed an elevated CD4:CD8 ratio in the bronchoalveolar lavage fluid, and cryoprobe lung biopsy results showed non-necrotizing granulomatous inflammation...
October 7, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
Keitaro Yoshida, Yu Mimura, Ryosuke Ishihara, Hiroshi Nishida, Yuji Komaki, Tomohito Minakuchi, Tomokazu Tsurugizawa, Masaru Mimura, Hideyuki Okano, Kenji F Tanaka, Norio Takata
BACKGROUND: Functional magnetic resonance imaging (fMRI) in mice is typically performed under anesthesia due to difficulties in holding the head of awake mice stably with a conventional three-point fixation method that uses a tooth-bar and earplugs. Although some studies have succeeded in fMRI in awake mice by attaching a head-post on the skull, this cannot be applied to fMRI using a high signal-to-noise ratio (SNR) cryogenic MRI-detector, CryoProbe, because it covers the head of a mouse closely...
October 1, 2016: Journal of Neuroscience Methods
Inderpaul Singh Sehgal, Sahajal Dhooria, Digambar Behera, Ritesh Agarwal
Foreign body (FB) inhalation in the tracheobronchial tree is an infrequently encountered event in adults. The diagnosis is suspected in the presence of a clinical history of aspiration and the presence of respiratory symptoms. Management involves confirmation by flexible bronchoscopy, which may be both diagnostic as well as therapeutic. However, in certain situations including those with large FB, FB embedded in granulation tissue or FB with very smooth margins, rigid bronchoscopy may be superior to flexible bronchoscopy in the retrieval of the FB...
September 2016: Lung India: Official Organ of Indian Chest Society
Andrew C Rau, Ryan Siskey, Jorge A Ochoa, Tracy Good
BACKGROUND: Creating appropriately-sized, lethal isotherms during cryoablation of renal tumors is critical in order to achieve sufficiently-sized zones of cell death. To ensure adequate cell death in target treatment locations, surgeons must carefully select the type, size, location, and number of probes to be used, as well as various probe operating parameters. OBJECTIVE: The current study investigates the effects of probe type, operating pressure, and clinical method on the resulting sizes of isotherms in an in vitro gelatin model...
2016: Open Biomedical Engineering Journal
Ji Y Buethe, Salim Abboud, Kristie Brock, Greg Nizialek, Rod Rezaee, Jay Wasman, Jonathan Frankel, Dean A Nakamoto
PURPOSE: To evaluate the imaging, histologic changes and safety of computed tomography (CT)-guided cryoablation of the parotid glands in a porcine model. MATERIALS AND METHODS: Unilateral CT-guided parotid gland cryoablation was performed in 5 juvenile miniature pigs. The ablated parotid glands underwent 2 cycles of 10-minute freeze and 5-minute thaw using three 17-g cryoprobes. The animals were monitored daily for complications including pain, frostbite, infection, and sialocele or fistula formation...
August 24, 2016: Journal of Vascular and Interventional Radiology: JVIR
Kirtee Raparia, Dara L Aisner, Timothy Craig Allen, Mary Beth Beasley, Alain Borczuk, Philip T Cagle, Vera Capelozzi, Sanja Dacic, Lida P Hariri, Keith M Kerr, Sylvie Lantuejoul, Mari Mino-Kenudson, Natasha Rekhtman, Anja C Roden, Sinchita Roy-Chowdhuri, Lynette Sholl, Maxwell L Smith, Eric Thunnissen, Ming Sound Tsao, Yasushi Yatabe
Transbronchial lung cryobiopsy involves using a cryoprobe rather than forceps to obtain a bronchoscopic biopsy. Recent studies have shown that transbronchial cryobiopsy provides a larger specimen than conventional transbronchial forceps biopsy, and that the interobserver agreement in the interpretation of cryobiopsy specimens is comparable to that of a surgical lung biopsy. This is encouraging, and transbronchial lung cryobiopsy clearly has a role in the workup and diagnosis of interstitial lung diseases. However, very few patients who have been studied underwent both transbronchial lung cryobiopsy and surgical lung biopsy, and the available data suggest that the diagnostic accuracy of cryobiopsy may not be similar to that of surgical lung biopsy...
July 21, 2016: Archives of Pathology & Laboratory Medicine
H Wurps, N Schönfeld, T T Bauer, M Bock, C Duve, R Sauer, T Mairinger, S Griff
BACKGROUND: There is only few data available on the use of cryotechnique during medical thoracoscopy. METHODS: Medical thoracoscopy was performed in consecutive patients with pleural effusion. Prospectively, biopsies were taken by rigid forceps, flexible forceps and cryoprobe. Specimen size, depth and diagnostic yield were compared. RESULTS: 80 Patients were included. 408 biopsies were taken (205 rigid biopsies, 104 flexible biopsies, 99 cryobiopsies)...
2016: BMC Pulmonary Medicine
Qianli Ma, Bin Shi, Yanchu Tian, Deruo Liu
BACKGROUND: Patients with secondary malignant tracheal and main bronchial tumors may suffer severe symptoms as a result of major airway obstruction. Curative surgical resection is usually not suitable because of the presence of metastatic disease and poor performance status. In this study, the use of bronchoscopic cryosurgery to reopen the airway is analyzed. METHODS: The clinical records of 37 patients who experienced secondary maglinancies from December 2001 to January 2013 were retrospectively reviewed...
July 2016: Thoracic Cancer
Mikhail Kazachkov, Alfin Vicencio
Foreign body removal is commonly performed with the rigid bronchoscope. However, based on recent literature, extraction with the flexible bronchoscope has increased in popularity. Here, we discuss a new tool - the flexible cryoprobe - that may enhance foreign body retrieval in select patients and comment on the methods of foreign body extraction in the view of common clinical practice. Pediatr Pulmonol. 2016; 51:886-888. © 2016 Wiley Periodicals, Inc.
September 2016: Pediatric Pulmonology
Matthew Ing, Rema A Oliver, Brian G G Oliver, William R Walsh, Jonathan P Williamson
BACKGROUND: Transbronchial lung biopsy using a cryoprobe is a novel way of sampling lung parenchyma. Correlation of freezing time with biopsy size and complications has not been evaluated in vivo. OBJECTIVES: The primary aim of the study is to evaluate the correlation between transbronchial cryobiopsy freezing time and size. The secondary aims are to evaluate histological quality of the biopsy and evaluate procedure-associated complications. METHODS: Transbronchial lung cryobiopsies were obtained from two anaesthetised sheep using a 1...
2016: Respiration; International Review of Thoracic Diseases
Brian M Ilfeld, Jessica Preciado, Andrea M Trescot
INTRODUCTION: Cryoneurolysis is the direct application of low temperatures to reversibly ablate peripheral nerves to provide pain relief. Recent development of a handheld cryoneurolysis device with small gauge probes and an integrated skin warmer broadens the clinical applications to include treatment of superficial nerves, further enabling treatments for pre-operative pain, post-surgical pain, chronic pain, and muscle movement disorders. AREAS COVERED: Cryoneurolysis is the direct application of cold temperatures to a peripheral nerve, resulting in reversible ablation due to Wallerian degeneration and nerve regeneration...
August 2016: Expert Review of Medical Devices
Joseph L McDevitt, Samdeep K Mouli, Albert A Nemcek, Robert J Lewandowski, Riad Salem, Kent T Sato
PURPOSE: To identify risk factors for local recurrence and major complications associated with percutaneous cryoablation of lung tumors. MATERIALS AND METHODS: All cases between April 2007 and September 2014 at 1 institution were retrospectively reviewed. Procedures were performed using computed tomography guidance and a double freeze-thaw protocol. Tumor progression was determined via World Health Organization guidelines, and complications were classified using SIR reporting standards...
September 2016: Journal of Vascular and Interventional Radiology: JVIR
David M DiBardino, Anthony R Lanfranco, Andrew R Haas
Cryotherapy is an evolving therapeutic and diagnostic tool used during bronchoscopy. Through rapid freeze-thaw cycles, cryotherapy causes cell death and tissue necrosis or tissue adherence that can be used via the flexible or rigid bronchoscope. This extreme cold can be used through the working channel of the bronchoscope via a specialized cryoprobe or directly with the use of spray cryotherapy. These properties allow for multiple bronchoscopic techniques, each with its own equipment and procedural, safety, and efficacy considerations...
August 2016: Annals of the American Thoracic Society
Hiroaki Nomori, Ikuo Yamazaki, Toshiya Kondo, Masaya Kanno
PURPOSES: To examine the efficiency of cryoablation using liquid nitrogen in lung tissue, we measured the size and temperature distribution of the frozen area (iceball) in gel and in the ex vivo pig lungs. METHODS: Cryoprobes with diameters of 2.4 and 3.4 mm (2.4D and 3.4D, respectively) were used. Three temperature sensors were positioned at the surface of the cryoprobe and at distances of 0.5 and 1.5 cm from the cryoprobe. The ex vivo pig lungs were perfused with 37 °C saline and inflated using ventilator to simulate in vivo lung conditions...
June 4, 2016: Surgery Today
José Javier Echevarria-Uraga, Julio Pérez-Izquierdo, Nerea García-Garai, Estíbaliz Gómez-Jiménez, Amaia Aramburu-Ojembarrena, Luis Tena-Tudanca, José L Miguélez-Vidales, Alberto Capelastegui-Saiz
BACKGROUND AND OBJECTIVE: Transbronchial cryobiopsy (TBCB) is a technique in which frozen samples of lung are obtained using a probe inserted through a bronchoscope. We performed a retrospective study to assess the performance of the TBCB procedure complemented by segmental bronchial blockade using an angioplasty balloon, in terms of diagnostic yield and safety in diffuse parenchymal lung disease (DPLD). METHODS: Data from 100 patients with suspected DPLD (clinical and radiological findings), who underwent TBCB in our institution to establish a definitive diagnosis, were reviewed...
August 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
Wendy Chan, Alina Akhbanbetova, Andrew J Quantock, Charles M Heard
The application of inhibitors of the Rho kinase pathway (ROCK inhibitors) to the surface of the eye in the form of eyedrops has beneficial effects which aid the recovery of diseased or injured endothelial cells that line the inner surface of the cornea. The aim of this study was to test the plausibility of delivering a selective ROCK inhibitor, Y-27632, to the cornea using a thin polymeric film. Mucoadhesive polymeric thin films were prepared incorporating Y-27632 and diffusional release into PBS was determined...
August 25, 2016: European Journal of Pharmaceutical Sciences
Hugh C J McGregor, Maythem Saeed, Andrew Surman, Eric C Ehman, Steven W Hetts, Mark W Wilson, Miles B Conrad
PURPOSE: To investigate the feasibility of percutaneous gallbladder cryoablation (GBC) under CT guidance in a swine model with histopathologic correlation. MATERIALS AND METHODS: Institutional Animal Care and Use Committee approval was obtained for this study protocol. Five pigs underwent GBC. Under CT guidance, 3-4 cryoprobes were positioned percutaneously at the gallbladder margins. Thermocouple probes were placed percutaneously at the gallbladder fundus, neck, free wall, and gallbladder fossa...
July 2016: Cardiovascular and Interventional Radiology
Sahajal Dhooria, Inderpaul Singh Sehgal, Amanjit Bal, Ashutosh Nath Aggarwal, Digambar Behera, Ritesh Agarwal
No abstract text is available yet for this article.
March 2016: Lung India: Official Organ of Indian Chest Society
Clémence Ligneul, Marco Palombo, Julien Valette
PURPOSE: To assess the potential correlation between metabolites diffusion and relaxation in the mouse brain, which is of importance for interpreting and modeling metabolite diffusion based on pure geometry, irrespective of relaxation properties (multicompartmental relaxation or surface relaxivity). METHODS: A new diffusion-weighted magnetic resonance spectroscopy sequence is introduced, dubbed "STE-LASER," which presents several nice properties, in particular the absence of cross-terms with selection gradients and a very clean localization...
March 28, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Hanine Inaty, Erik Folch, Robert Berger, Sebastian Fernandez-Bussy, Sumit Chatterji, Daniel Alape, Adnan Majid
RATIONALE: Cryodebridement (CD) refers to the removal of obstructive material from the lumen of the tracheobronchial tree by freezing with a cryoprobe, which is usually inserted through a flexible bronchoscope. This method of achieving instant recanalization of airways has been established for over 20 years, but published experience comprises limited case series. OBJECTIVES: This study describes a single large-volume referral center experience, including clinical outcomes and safety profile...
June 2016: Annals of the American Thoracic Society
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