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Cryoprobe

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https://www.readbyqxmd.com/read/28593055/a-surgical-cryoprobe-for-targeted-transcorneal-freezing-and-endothelial-cell-removal
#1
Alina Akhbanbetova, Shinichiro Nakano, Stacy L Littlechild, Robert D Young, Madara Zvirgzdina, Nigel J Fullwood, Ian Weston, Philip Weston, Shigeru Kinoshita, Naoki Okumura, Noriko Koizumi, Andrew J Quantock
PURPOSE: To examine the effects of transcorneal freezing using a new cryoprobe designed for corneal endothelial surgery. METHODS: A freezing console employing nitrous oxide as a cryogen was used to cool a series of different cryoprobe tip designs made of silver for high thermal conductivity. In vitro studies were conducted on 426 porcine corneas, followed by preliminary in vivo investigations on three rabbit corneas. RESULTS: The corneal epithelium was destroyed by transcorneal freezing, as expected; however, the epithelial basement membrane remained intact...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28580148/post-tuberculosis-mycetoma-bronchoscopic-removal
#2
Liam J Chawke, Eoin B Hunt, Marcus P Kennedy, Desmond M Murphy
A 76-year-old male non-smoker presented to our institution with cough and haemoptysis. He had been treated for cavitatory pulmonary Mycobacterium tuberculosis of the right upper lobe 10 years previously. Chest radiograph and subsequent computed tomography (CT) of the chest demonstrated a right upper cavity containing a mass suspicious for mycetoma. Flexible bronchoscopy under conscious sedation demonstrated a mass obstructing the anterior segment of the right upper lobe. The abnormality was subsequently removed using a flexible endobronchial cryoprobe...
July 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28558164/advanced-solvent-signal-suppression-for-the-acquisition-of-1d-and-2d-nmr-spectra-of-scotch-whisky
#3
Will Kew, Nicholle G A Bell, Ian Goodall, Dušan Uhrín
A simple and robust solvent suppression technique that enables acquisition of high quality 1D (1) H NMR spectra of alcoholic beverages on cryoprobe instruments was developed and applied to acquire NMR spectra of Scotch Whisky. The method uses three channels to suppress signals of water and ethanol, including those of (13) C satellites of ethanol. It is executed in automation allowing high throughput investigations of alcoholic beverages. Based on the well-established 1D NOESY solvent suppression technique, this method suppresses the solvent at the beginning of the pulse sequence, producing pure phase signals minimally affected by the relaxation...
May 30, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/28543277/experimental-study-of-cryofreezing-energy-applications-on-the-ventricular-myocardium-using-sheep-hearts
#4
Kaoru Okishige, Peter L Friedman
BACKGROUND: Cryofreezing energy has been utilized to abolish arrhythmogenic substrates of various kinds of tachyarrhythmias. However, systematic electrophysiological and histological investigations of cryothermia have never been performed. The aim of this study was to clarify those aspects using sheep beating hearts. METHODS: A total of eight adult sheep were utilized under total anesthesia, and a pericardial cradle was made by opening the pericardium. Eight epicardial plaque electrodes were sutured on the epicardial surface of the left ventricle 2∼3 cm apart from each other...
May 23, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28514898/assessment-of-cryosurgical-device-performance-using-a-3d-tissue-engineered-cancer-model
#5
John M Baust, Anthony Robilotto, Kristi K Snyder, Kimberly Santucci, Jennie Stewart, Robert Van Buskirk, John G Baust
As the clinical use of cryoablation for the treatment of cancer has increased, so too has the need for knowledge on the dynamic environment within the frozen mass created by a cryoprobe. While a number of factors exist, an understanding of the iceball size, critical isotherm distribution/penetration, and the resultant lethal zone created by a cryoprobe are critical for clinical application. To this end, cryoprobe performance is typically characterized based on the iceball size and temperature penetration in phantom gel models...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28412936/-1-h-nmr-analysis-of-feces-new-possibilities-in-the-helminthes-infections-research
#6
Sarantos Kostidis, Daria Kokova, Natalia Dementeva, Irina V Saltykova, Hye Kyong Kim, Young Hae Choi, Oleg A Mayboroda
BACKGROUND: Analysis of the stool samples is an essential part of routine diagnostics of the helminthes infections. However, the standard methods such Kato and Kato-Katz utilize only a fraction of the information available. Here we present a method based on the nuclear magnetic resonance spectroscopy (NMR) which could be auxiliary to the standard procedures by evaluating the complex metabolic profiles (or phenotypes) of the samples. METHOD: The samples were collected over the period of June-July 2015, frozen at -20 °C at the site of collection and transferred within four hours for the permanent storage at -80 °C...
April 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28353119/safety-and-feasibility-of-pleural-cryobiopsy-compared-to-forceps-biopsy-during-semi-rigid-pleuroscopy
#7
Vikas Pathak, Ray W Shepherd, Ehab Hussein, Rajiv Malhotra
BACKGROUND: Pleural biopsy is often obtained in patients with undiagnosed exudative pleural effusion during pleuroscopy. Standard forceps have been traditionally used for the biopsy. Cryoprobes are being increasingly used for transbronchial lung biopsy as they obtain larger specimens and have less crush artifact. However, the safety and feasibility of cryoprobe biopsy compared to standard forceps for pleural biopsy has not been fully assessed. OBJECTIVES: The objective of this study was to demonstrate the safety and feasibility of cryoprobe biopsy in the pleural space using semi-rigid pleuroscopy...
March 28, 2017: Lung
https://www.readbyqxmd.com/read/28323734/radial-probe-ultrasound-guided-cryobiopsy
#8
Ilya G Berim, Ali I Saeed, Ahmed Awab, Adam Highley, Agnes Colanta, Fawad Chaudry
Fluoroscopy-guided transbronchial forceps biopsy has a low diagnostic yield in patients with radiographic suspicion of interstitial lung disease. Cryobiopsy has a higher diagnostic yield likely due to preserved lung architecture and larger biopsies; however, there is an increased risk of major airway bleeding and pneumothorax. Simultaneous use of endobronchial balloon blocker allows for containment of bleeding after cryobiopsy to the affected lobe. In the current article we describe use of radial ultrasound in identification of a target lung parenchyma without a major blood vessel adjacent to distal bronchi...
April 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28245447/transbronchial-lung-cryobiopsy-in-diffuse-parenchymal-lung-disease-comparison-between-biopsy-from-1-segment-and-biopsy-from-2-segments-diagnostic-yield-and-complications
#9
Claudia Ravaglia, Athol U Wells, Sara Tomassetti, Alessandra Dubini, Alberto Cavazza, Sara Piciucchi, Nicola Sverzellati, Carlo Gurioli, Christian Gurioli, Ulrich Costabel, Paola Tantalocco, Jay H Ryu, Marco Chilosi, Venerino Poletti
BACKGROUND: Transbronchial lung cryobiopsy is an innovative method of obtaining samples from the parenchyma of patients with diffuse parenchymal lung diseases. However, the technique is not yet standardized, and uncertainty exists about the optimal protocol, including the number of samples, the biopsy size, and the choice of the biopsy site. OBJECTIVES: To compare the diagnostic yield and complications of cryobiopsy with different strategies adopted to sample lung tissue (number of samples, biopsy site, and sample size)...
2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28169912/radial-probe-ultrasound-guided-cryobiopsy
#10
Ilya G Berim, Ali I Saeed, Ahmed Awab, Adam Highley, Agnes Colanta, Fawad Chaudry
Fluoroscopy-guided transbronchial forceps biopsy has a low diagnostic yield in patients with radiographic suspicion of interstitial lung disease. Cryobiopsy has a higher diagnostic yield likely due to preserved lung architecture and larger biopsies; however, there is an increased risk of major airway bleeding and pneumothorax. Simultaneous use of endobronchial balloon blocker allows for containment of bleeding after cryobiopsy to the affected lobe. In the current article we describe use of radial ultrasound in identification of a target lung parenchyma without a major blood vessel adjacent to distal bronchi...
February 6, 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28114787/multipoint-thermal-sensors-associated-with-improved-oncologic-outcomes-following-cryoablation
#11
Jeremy W Martin, Roshan M Patel, Zhamshid Okhunov, Aashay Vyas, Duane Vajgrt, Ralph V Clayman
INTRODUCTION: Cryoablation (CA) is a minimally invasive modality for the management of small renal cortical neoplasms (RCN). Effective ablation is dependent on achieving target temperatures during CA that result in tumor cell death. We investigated long-term oncologic outcomes following CA using multipoint thermal sensors (MTS), which allow precise temperature determination at four points along the needle. METHODS: We performed a retrospective review of 20 patients with <4 cm RCN who underwent de novo CA from 2005 to 2009...
April 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28076822/an-in-vitro-analysis-of-the-size-and-shape-of-cryolesions-for-facet-joint-denervation
#12
T Wolter, Y Bozhkov, S M Knoeller
OBJECTIVES: Lumbar facet joint syndrome (LFJS) is the cause of lower back pain in 15-54% of the patients. Clinical studies of cryotherapy for LFJS have reported promising outcomes. However, few studies have focused on the technical aspects of cryoneurolysis for LFJS. The aim of the study was to determine the size and shape of cryolesions in vitro and to determine how they are affected by the duration of freezing, size of the cryoprobe and distance and angulation to an osseous boundary layer...
February 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28072428/3d-modelling-on-biodegradable-nanoparticle-enhanced-cryoablation-of-liver-tumor-based-on-real-anatomical-model
#13
S Y Xu, Z Z He, Y X Zhou, J Liu
BACKGROUND: Nanoparticle-enhanced freezing is of great importance for developing a conformal targeted cryoablation for liver tumor with complex shape. However, the safety and biocompatibility of nanoparticles should also be of major concerns. OBJECTIVE: This study is to investigate the enhanced cryoablation mediated by the MgO nanoparticles which are nontoxic, biodegradable, and have few side-effects on the human body. MATERIALS AND METHODS: A three-dimensional numerical model has been developed based on a real geometrical anatomical structure to characterize such nanocryosurgical freezing of liver tumor...
November 2016: Cryo Letters
https://www.readbyqxmd.com/read/28002868/ultrasound-guided-cryoanalgesia-of-peripheral-nerve-lesions
#14
Sahlya Djebbar, Ignacio M Rossi, Ronald S Adler
The real-time nature of ultrasound makes it ideally suited to provide guidance for a variety of musculoskeletal interventional procedures involving peripheral nerves. Continuous observation of the needle ensures proper placement and allows continuous monitoring when performing localized ablative therapy and therefore more accurate positioning of a cryoprobe, use of smaller needles, as well as access to small structures. We describe our experience performing cryoablative procedures. Patients undergoing cryoneurolysis have largely reported varying degrees of long-term pain relief and improvement in function; no serious complications have yet been identified...
November 2016: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/27977039/thermal-conductivity-of-human-bone-in-cryoprobe-freezing-as-related-to-density
#15
Kyle E Walker, Todd Baldini, Bennie G Lindeque
Cryoprobes create localized cell destruction through freezing. Bone is resistant to temperature flow but is susceptible to freezing necrosis at warmer temperatures than tumor cells. Few studies have determined the thermal conductivity of human bone. No studies have examined conductivity as related to density. The study goal was to examine thermal conductivity in human bone while comparing differences between cancellous and cortical bone. An additional goal was to establish a relationship between bone density and thermal conductivity...
March 1, 2017: Orthopedics
https://www.readbyqxmd.com/read/27886022/fracture-risk-of-vertebral-bodies-after-cryosurgery-using-a-miniature-cryoprobe-a-biomechanical-in-vitro-analysis-on-human-bones
#16
K Zarghooni, L Westermann, R Sobottke, M Röllinghoff, J Bredow, J Siewe, Peer Eysel, M J Scheyerer
INTRODUCTION: Due to spinal instability and compressive neurologic deficits surgical management is sometimes necessary in patients with metastatic spinal lesions. However, in some cases open surgery is not possible and minimally invasive procedures, like cryoablation, are needed. The aim of the current study was to investigate whether a miniature cryoprobe provides adequate tissue cooling in vertebrae and to evaluate the direct impact of cryosurgery on vertebral body stability. MATERIALS AND METHODS: Twelve thoracic vertebral bodies were harvested from fresh cadavers...
November 18, 2016: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/27833528/gray-and-white-matter-demyelination-and-remyelination-detected-with-multimodal-quantitative-mri-analysis-at-11-7t-in-a-chronic-mouse-model-of-multiple-sclerosis
#17
Alexandra Petiet, Marie-Stéphane Aigrot, Bruno Stankoff
Myelin is a component of the nervous system that is disrupted in multiple sclerosis, resulting in neuro-axonal degeneration. The longitudinal effect of chronic cuprizone-induced demyelination was investigated in the cerebral gray and white matter of treated mice and the spontaneous remyelination upon treatment interruption. Multimodal Magnetic Resonance Imaging and a Cryoprobe were used at 11.7T to measure signal intensity ratios, T2 values and diffusion metrics. The results showed significant and reversible modifications in white matter and gray matter regions such as in the rostral and caudal corpus callosum, the external capsule, the cerebellar peduncles, the caudate putamen, the thalamus, and the somatosensory cortex of treated mice...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27832044/early-results-of-the-modified-right-atrial-lesion-set-for-the-cox-cryomaze-procedure
#18
Faisal Habib Cheema, Muhammad Amir Younus, Osama T Siddiqui, Muhammad Jabran Younus, Muhammad Arif Mahmood, Mohammad Bin Pervez, Harold G Roberts
OBJECTIVE: The standard right atrial lesion (RAL) set, as originally outlined in the Cox-Maze III procedure, can be technically challenging when using a cryoprobe to create the lesions. We report our initial experience with an alternative set of RALs for the surgical treatment of atrial fibrillation (AF). METHODS: Between September 2011 and January 2015, a total of 112 patients underwent a CryoMaze procedure with biatrial lesions using argon-based cryoablation (cryoprobe temperature, -160°C)...
September 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/27831814/pneumomediastinum-and-extensive-subcutaneous-emphysema-after-cryoprobe-transbronchial-lung-biopsy
#19
Karan Madan, Swapnil Mehta, Nishkarsh Gupta, Vijay Hadda, Anant Mohan, Randeep Guleria
No abstract text is available yet for this article.
November 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27758996/crohn-s-disease-associated-interstitial-lung-disease-mimicking-sarcoidosis-a-case-report-and-review-of-the-literature
#20
REVIEW
Choua Thao, Amir Lagstein, Tadashi Allen, Huseyin Erhan Dincer, Hyun Joo Kim
Respiratory involvement in Crohn's disease (CD) is a rare manifestation known to involve the large and small airways, lung parenchyma, and pleura. The clinical presentation is nonspecific, and diagnostic tests can mimic other pulmonary diseases, posing a diagnostic challenge and delay in treatment. We report a case of a 60-year-old female with a history of CD and psoriatic arthritis who presented with dyspnea, fever, and cough with abnormal radiological findings. Diagnostic testing revealed an elevated CD4:CD8 ratio in the bronchoalveolar lavage fluid, and cryoprobe lung biopsy results showed non-necrotizing granulomatous inflammation...
October 7, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
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