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Cryoprobe

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https://www.readbyqxmd.com/read/29744650/a-novel-in-vivo-porcine-model-of-intervertebral-disc-degeneration-induced-by-cryoinjury
#1
Charles-Henri Flouzat-Lachaniette, Nicolas Jullien, Charlie Bouthors, Eric Beohou, Béatrice Laurent, Philippe Bierling, Arnaud Dubory, Hélène Rouard
PURPOSE: Degenerative disc disease involves sequential events that lead to the loss of cells, a decrease in disc matrix production, disc dehydration, and alteration of its biomechanical properties. The aim of this study was to determine whether cryoinjury of the nucleus pulposus performed through endplate perforation contributes to disc degeneration and to compare this technique with standard methods. METHOD: Under general anesthesia, the lumbar discs of six pigs were exposed and randomly submitted to needle puncture of the annulus fibrosus (NeP), isolated endplate injury (EP), or cryoinjury using a 2...
May 10, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29734432/a-thermal-protective-urethral-heater-applied-to-modulate-the-prostate-cryoablation-area
#2
B Qian, H Zhao, B Xu, M Lan
BACKGROUND: Urethral warmer and cryoheater are invented and applied in cryoablation to overcome urethral cryoinjury, but these devices cannot be fixed and precisely control the released heat which excessively reduces the effective ablation area. Current warmers enlarge the operation difficulty and decrease the precision in temperature control. OBJECTIVE: A reformed catheter termed urethral heater aims to protect the urethra and simultaneously control the released heat so as to meet the aid of doctors' convenient operation in effective therapy, device fixation and precise heat controllability...
July 2017: Cryo Letters
https://www.readbyqxmd.com/read/29657717/closure-of-a-bronchopleural-fistula-complicating-cryoprobe-biopsy-of-the-lung
#3
Rahul H Mehta, Jeffrey Hoag, Amit Borah, Emil Abramian
Cryoprobe biopsies are routinely performed by the interventional pulmonologist. Diagnostic yields are larger, with complication rates that are equal to or lower than that of traditional forceps biopsies. We will specifically evaluate one instance where a cryoprobe biopsy led to an alveolo-pleural fistula that did not resolve with simple tube thoracostomy. An endobronchial valve was placed and successfully resolved the pneumothorax and persistent air leak.
July 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29649700/detailed-spectral-profile-analysis-of-electrocorticograms-during-freezing-against-penicillin-induced-epileptiform-discharges-in-the-anesthetized-rat
#4
Tatsuji Tokiwa, Lev Zimin, Takao Inoue, Sadahiro Nomura, Michiyasu Suzuki, Takeshi Yamakawa
OBJECTIVES: Cryosurgery is an alternative technique for minimally invasive treatment of lesions. We have recently examined cryosurgery for epilepsy in animal models, and found that penicillin G (PG)-induced epileptiform discharges (EDs) mostly vanished after freezing. However, EDs were provoked again after insufficient freezing. Inadequate freezing is not visually detectable during and just after freezing and is not predictable beforehand. To manage this problem, we examined whether intraoperative monitoring of electrocorticograms (ECoGs) can predict recurrence of EDs after cryosurgery...
March 29, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29626465/adjuvant-androgen-deprivation-therapy-following-prostate-total-cryoablation-in-high-risk-localized-prostate-cancer-patients-open-labeled-randomized-clinical-trial
#5
Chung-Hsin Chen, Yeong-Shiau Pu
PURPOSE: To investigate the efficacy and safety profile of 12-month adjuvant androgen-deprivation therapy (ADT) following total-gland cryoablation (TGC) in patients with high-risk localized prostate cancer (HRLPC). MATERIALS AND METHODS: This open-label randomized trial included 38 HRLPC patients who received TGC between July 2011 and March 2013. Within 4 weeks after TGC, subjects were randomly assigned (1:1) to either the 12-month adjuvant ADT or non-adjuvant ADT group...
April 4, 2018: Cryobiology
https://www.readbyqxmd.com/read/29621494/pirfenidone-inhibits-cryoablation-induced-local-macrophage-infiltration-along-with-its-associated-tgfb1-expression-and-serum-cytokine-level-in-a-mouse-model
#6
Yangkui Gu, Govindarajan Srimathveeravalli, Liqun Cai, Eisuke Ueshima, Majid Maybody, Hooman Yarmohammadi, Yuan-Shan Zhu, Jeremy C Durack, Stephen B Solomon, Jonathan A Coleman, Joseph P Erinjeri
PURPOSE: To investigate the effects of pirfenidone (PFD) on post-cryoablation inflammation in a mouse model. MATERIALS AND METHODS: In this IACUC-approved study, eighty Balb/c mice were randomly divided into four groups (20/group): sham + vehicle, sham + PFD, cryoablation + vehicle, and cryoablation + PFD. For cryoablation groups, a 20% freeze rate cryoablation (20 s to less than -100 °C) was used to ablate normal muscle in the right flank. For sham groups, the cryoprobe was advanced into the flank and maintained for 20 s without ablation...
April 2, 2018: Cryobiology
https://www.readbyqxmd.com/read/29610630/feasibility-and-safety-of-pleuroscopic-cryobiopsy-of-the-pleura-a-prospective-study
#7
Chia-Hung Chen, Wen-Chien Cheng, Biing-Ru Wu, Chih-Yu Chen, Wei-Chun Chen, Wei-Chih Liao, Chih-Yen Tu
Background: The aim of this study was thus to evaluate the feasibility and safety of taking biopsy specimens by cryoprobe from the parietal pleura during semirigid pleuroscope. Methods: In a single-center, observational, prospective study, patients with exudative pleural effusion (EPE) were evaluated with a semirigid pleuroscope between January 2015 and July 2017. Each patient underwent pleural biopsy using flexible forceps and flexible cryoprobe through pleuroscope following diagnostic thoracentesis and closed pleural biopsy (CPB)...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29580711/clinical-outcomes-after-pulmonary-cryoablation-with-the-use-of-a-triple-freeze-protocol
#8
Gray R Lyons, Gulce Askin, Bradley B Pua
PURPOSE: To elucidate clinical variables associated with safety and efficacy in patients after cryoablation of pulmonary tumors with the use of a triple freeze protocol. MATERIALS AND METHODS: Percutaneous cryoablation of pulmonary tumors was performed using Galil Medical cryoprobes (Arden Hills, Minnesota) with a triple freeze protocol: 67 nodules in 42 patients were treated at a single institution from 2012 to 2016. Average nodule diameter was 1.6 cm (range 0...
March 23, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29557170/substantial-decrease-in-plasmalogen-in-the-heart-associated-with-tafazzin-deficiency
#9
Tomohiro Kimura, Atsuko Kimura, Mindong Ren, Bob Berno, Yang Xu, Michael Schlame, Richard M Epand
Tafazzin is the mitochondrial enzyme that catalyzes transacylation between a phospholipid and a lysophospholipid in remodeling. Mutations in tafazzin cause Barth syndrome, a potentially life-threatening disease with the major symptom of cardiomyopathy. In the tafazzin-deficient heart, cardiolipin (CL) acyl chains become abnormally heterogeneous unlike those in the normal heart with a single dominant linoleoyl species; tetralinoleoyl CL. In addition, the amount of CL decreases and monolysocardiolipin (MLCL) accumulates...
March 20, 2018: Biochemistry
https://www.readbyqxmd.com/read/29506903/a-comparison-of-bleeding-complications-in-patients-undergoing-percutaneous-renal-cryoablation-using-cryoprobes-with-and-without-heat-based-track-ablation
#10
Collin H Schmit, Matthew R Callstrom, Stephen A Boorjian, Matthew P Johnson, Thomas D Atwell, A Nicholas Kurup, Georgianna R Schultz, R Houston Thompson, Grant D Schmit
PURPOSE: To determine if the use of heat-based track ablation with new-generation cryoprobes is associated with decreased renal cryoablation bleeding complications. MATERIALS AND METHODS: Eighty-nine patients who underwent percutaneous cryoablation for treatment of a solitary renal mass with the use of cryoprobes with track ablation (CwTA) from October 29, 2015, to May 18, 2017, were compared with a propensity score-matched control group of 178 patients who underwent treatment with the use of cryoprobes without track ablation (Cw/oTA) from January 5, 2012, to October 28, 2015...
March 3, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29480808/in-vivo-optoacoustic-temperature-imaging-for-image-guided-cryotherapy-of-prostate-cancer
#11
E V Petrova, H P Brecht, M Motamedi, A A Oraevsky, S A Ermilov
The objective of this study is to demonstrate in vivo the feasibility of optoacoustic temperature imaging during cryotherapy of prostate cancer. We developed a preclinical prototype optoacoustic temperature imager that included pulsed optical excitation at a wavelength of 805 nm, a modified clinical transrectal ultrasound probe, a parallel data acquisition system, image processing and visualization software. Cryotherapy of a canine prostate was performed in vivo using a commercial clinical system, Cryocare® CS, with an integrated ultrasound imaging...
March 21, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29396685/the-role-of-exposure-time-in-computerized-training-of-prostate-cryosurgery-performance-comparison-of-surgical-residents-with-engineering-students
#12
Purva Joshi, Anjali Sehrawat, Yoed Rabin
PURPOSE: This study aims at the evaluation of a prototype of a computerized trainer for cryosurgery-the controlled destruction of cancer tumors by freezing. The hypothesis in this study is that computer-based cryosurgery training for an optimal cryoprobe layout is essentially a matter of exposure time, rather than trainee background or the specific computer-generated planning target. Key geometric features under considerations are associated with spatial limitations on cryoprobes placement and the match between the resulted thermal field and the unique anatomy of the prostate...
April 2018: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29395896/pilot-study-of-the-safety-and-efficacy-of-gallbladder-cryoablation-in-a-porcine-model-midterm-results
#13
Hugh C J McGregor, Andrew Surman, Adrian Fernandez, Maythem Saeed, Mark Wilson, Steve Hetts, Miles Conrad
PURPOSE: To investigate the midterm safety and efficacy of computed tomography (CT)-guided percutaneous gallbladder cryoablation in swine. MATERIALS AND METHODS: Three swine underwent gallbladder cryoablation. Cryoprobes were positioned percutaneously at the gallbladder margins or within the gallbladder lumen under CT guidance. Two freeze/thaw cycles were performed. One animal was euthanized on postprocedure day 4 as a result of hematemesis unrelated to the ablation...
March 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29341926/direct-detection-of-carbon-and-nitrogen-nuclei-for-high-resolution-analysis-of-intrinsically-disordered-proteins-using-nmr-spectroscopy
#14
E B Gibbs, R W Kriwacki
Nuclear magnetic resonance spectroscopy (NMR) is a powerful technique for characterizing the structural and dynamic properties of intrinsically disordered proteins and protein regions (IDPs & IDRs). However, the application of NMR to IDPs has been limited by poor chemical shift dispersion in two-dimensional (2D) 1H-15N heteronuclear correlation spectra. Among the various detection schemes available for heteronuclear correlation spectroscopy, 13C direct-detection has become a mainstay for investigations of IDPs owing to the favorable chemical shift dispersion in 2D 13C'-15N correlation spectra...
January 13, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29338729/computational-study-of-the-effects-of-arterial-bifurcation-on-the-temperature-distribution-during-cryosurgery
#15
Yong-Chang Zheng, Jun-Hong Wu, Zhi-Zhu He, Shao-Jiong Huang
BACKGROUND: Thermally significant blood flows into locally cooled diseased tissues and warm them during cryosurgery so that the iceball is often hard to cover the whole diseased volume. This paper is aimed at investigating the effects of large arterial bifurcation on the temperature distribution during cryosurgery through simulation method. METHODS: A parametric geometry model is introduced to construct a close-to-real arterial bifurcation. The three-dimensional transient conjugate heat transfer between bifurcated artery and solid tissues with phase change during cryosurgery is performed by finite volume method...
January 16, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29261578/cryobiopsy-of-the-pleura-an-improved-diagnostic-tool
#16
Syed Z Tousheed, Poojaramuddanahally Hanumantharayappa Manjunath, Sagar Chandrasekar, Bangalore Venkatraman Murali Mohan, Hemanth Kumar, Kedar R Hibare, Ranganatha Ramanjaneya
BACKGROUND: Medical thoracoscopy (rigid and semirigid pleuroscopy) has revolutionized the approach to the diagnosis of pleural disease by offering a very high diagnostic yield. Rigid pleuroscopy offers the advantages of therapeutic intervention and larger biopsy specimens, whereas semirigid pleuroscopy using a standard biopsy forceps yields smaller and more superficial pleural samples. Cryobiopsy through semirigid pleuroscope in anecdotal studies has been used to overcome these disadvantages...
January 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29214060/interstitial-lung-disease-the-diagnostic-role-of-bronchoscopy
#17
REVIEW
Jad Kebbe, Tony Abdo
Interstitial lung diseases (ILDs) form one of the most fascinating fields in pulmonary medicine. They also pose one of the greatest challenges for accurate diagnosis and proper treatment. Even within the recommended and warranted multidisciplinary approach, differentiating between one disease and another may lead to frustration, especially when proper lung tissue is not available for adequate pathological review. A surgical lung biopsy (SLB) might render enough tissue for histopathology, but this could come at the expense of high morbidity and even mortality, as in the case of usual interstitial pneumonia (UIP)...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29089355/assessment-of-retinoblastoma-rna-reflux-after-intravitreal-injection-of-melphalan
#18
Ursula Winter, Michael Nicolas, Mariana Sgroi, Claudia Sampor, Ana Torbidoni, Adriana Fandiño, Guillermo L Chantada, Francis L Munier, Paula Schaiquevich
BACKGROUND: Intravitreal injection of chemotherapy in retinoblastoma eyes with vitreous seeds may lead to a risk of extraocular tumour dissemination that has not been assessed so far. AIMS: To develop a sensitive and clinically feasible technique to assess for potential retinoblastoma cell reflux after intravitreal injection of melphalan. METHODS: Filter papers were cut in 6 mm diameter circles and sterilised before use. Eyes with retinoblastoma vitreous seeds (group D, International Classification) received weekly intravitreal melphalan injections (20 µg or 30 µg/dose) followed by cryotherapy as part of local treatment...
March 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29043385/whole-gland-prostate-cancer-cryoablation-with-magnetic-resonance-imaging-guidance-one-year-follow-up
#19
Kristin A Kinsman, Mariah L White, Lance A Mynderse, Akira Kawashima, Karen Rampton, Krzysztof R Gorny, Thomas D Atwell, Joel P Felmlee, Matthew R Callstrom, David A Woodrum
PURPOSE: Patients who develop prostate cancer after prior abdominal perineal resection are poor surgical candidates, and have limited treatment options. Therefore, our goal is to present results from a single institutional experience of four patients who underwent whole gland MRI-guided cryoablation with a history complicated by prior abdominoperineal resection. MATERIALS AND METHODS: Four MRI-guided cryoablative treatments (mean age 64, range 59-69 years) for primary and locally recurrent prostate adenocarcinoma were retrospectively reviewed in patients with prior abdominal perineal resection for colorectal cancer (3) and juvenile polyposis (1)...
February 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29037373/fast-inverse-prediction-of-the-freezing-front-in-cryosurgery
#20
REVIEW
Mohamed Hafid, Marcel Lacroix
Cryosurgery has become a well-established technique for the ablation of undesirable tissues such as tumors and cancers. The motivation for this study is to improve the efficacy and safety of this technique. This study presents an inverse heat transfer method for monitoring the motion of the freezing front from a cryoprobe. With the help of a thermocouple inserted into the layer of diseased tissue, the inverse heat transfer method estimates simultaneously the blood perfusion rate and the thermal conductivities of both frozen and unfrozen tissues...
October 2017: Journal of Thermal Biology
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