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https://www.readbyqxmd.com/read/28845941/-ultrasound-guided-percutaneous-cryoablation-of-renal-tumors
#1
D V Enikeev, P V Glybochko, Yu G Alyaev, L M Rapoport, A V Amosov, T M Alekseeva, M E Enikeev, D G Tsarichenko, D V Chinenov, L D Kozmin, Z K Dzhalaev, M S Taratkin
INTRODUCTION: Surgery remains the gold-standard curative treatment for localized (T1) renal carcinoma. However, recent medical-technological advances have led to the development of new minimally invasive treatment options, one of which is percutaneous cryoablation. AIM: To assess the effectiveness and safety of ultrasound-guided percutaneous cryoablation of renal tumors. MATERIALS AND METHODS: The study comprised 12 patients aged 52 to 76 years who underwent ultrasound-guided percutaneous cryoablation of renal tumors from 2015 to 2017...
July 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28840020/transbronchial-cryobiopsy-for-diffuse-parenchymal-lung-disease-a-state-of-the-art-review-of-procedural-techniques-current-evidence-and-future-challenges
#2
REVIEW
Robert J Lentz, A Christine Argento, Thomas V Colby, Otis B Rickman, Fabien Maldonado
Transbronchial lung biopsy with a cryoprobe, or cryobiopsy, is a promising new bronchoscopic biopsy technique capable of obtaining larger and better-preserved samples than previously possible using traditional biopsy forceps. Over two dozen case series and several small randomized trials are now available describing experiences with this technique, largely for the diagnosis of diffuse parenchymal lung disease (DPLD), in which the reported diagnostic yield is typically 70% to 80%. Cryobiopsy technique varies widely between centers and this predominantly single center-based retrospective literature heterogeneously defines diagnostic yield and complications, limiting the degree to which this technique can be compared between centers or to surgical lung biopsy (SLB)...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28838486/evaluation-of-a-novel-cryoprobe-for-atrial-ablation-in-a-chronic-ovine-model
#3
Matthew R Schill, Spencer J Melby, Molly Speltz, May Breitbach, Richard B Schuessler, Ralph J Damiano
PURPOSE: Cryoablation is used in the treatment of atrial fibrillation and other cardiac arrhythmias. This study evaluated a novel 10-cm flexible nitrous oxide cryoprobe in an ovine model of atrial ablation. DESCRIPTION: Six sheep were anesthetized, underwent a left thoracotomy, and were placed on cardiopulmonary bypass. A left atriotomy was performed, and the cryoprobe was applied endocardially for 120 seconds at less than -40°C to 4 sites on the left atrium. The atrium was closed and the animals were allowed to recover...
September 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28828515/changes-in-perioperative-systolic-blood-pressure-in-percutaneous-renal-mass-cryoablation
#4
Sung Yoon Park, Young Taik Oh, Kyunghwa Han, Dae Chul Jung, Man Deuk Kim, Jong Yun Won
OBJECTIVES: To analyze changes in systolic blood pressure (SBP) in the perioperative period of percutaneous renal mass cryoablation and risk factors. METHODS: This retrospective study included 54 patients who underwent percutaneous renal cryoablation. SBP before ablation (pre-Tx), during ablation (intra-Tx), immediately after ablation (post-Tx), and before discharge (discharge) were measured using a BP cuff. The highest SBP during cryoablation was regarded as SBP at intra-Tx...
August 21, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28819722/carbon-and-amide-detect-backbone-assignment-methods-of-a-novel-repeat-protein-from-the-staphylocoagulase-in-s-aureus
#5
Markus Voehler, Maddur Appajaiah Ashoka, Jens Meiler, Paul E Bock
The C-terminal repeat domain of staphylocoagulase that is secreted by the S. aureus is believed to play an important role interacting with fibrinogen and promotes blood clotting. To study this interaction by NMR, full assignment of each amide residue in the HSQC spectrum was required. Despite of the short sequence of the repeat construct, the HSQC spectrum contained a substantial amount of overlapped and exchange broadened resonances, indicating little secondary or tertiary structure. This caused severe problems while using the conventional, amide based NMR method for the backbone assignment...
August 17, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28743122/utility-of-transbronchial-lung-cryobiopsy-in-non-interstitial-diseases
#6
Olivia Sánchez-Cabral, Dina Martínez-Mendoza, Sebastián Fernandez-Bussy, Berenice López-González, Carolina Perea-Talamantes, Rosa María Rivera-Rosales, César Luna-Rivero, José Arturo Martínez-Orozco, Luis Felipe Flores-Suárez, Patricio Santillán-Doherty, Gustavo Reyes-Terán
BACKGROUND: Transbronchial lung cryobiopsy (TLCB), performed with a flexible cryoprobe, is an interventional pulmonology procedure that has proved its diagnostic value for interstitial pulmonary disease. However, it has not been explored extensively as a diagnostic tool for patients with non-interstitial lung pathology, including infectious and malignant diseases. OBJECTIVE: To evaluate the diagnostic yield and safety of an interventional pulmonology approach that integrates TLCB and bronchoalveolar lavage (BAL) for the diagnosis of non-interstitial pulmonary disease...
2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28731368/computerized-planning-of-prostate-cryosurgery-and-shape-considerations
#7
Purva Joshi, Anjali Sehrawat, Yoed Rabin
The current study aims to explore possible relationships between various prostate shapes and the difficulty in creating a computer-based plan for cryosurgery. This research effort is a part of an ongoing study to develop computational means in order to improve cryosurgery training and education. This study uses a computerized planner-a key building block of a recently developed prototype for cryosurgery training. The quality of planning is measured by the overall defect volume, a proprietary concept which refers to undercooled areas internal to the target region and overcooled areas external to it...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28727387/focal-cryotherapy-step-by-step-technique-description
#8
Cristina Redondo, Victor Srougi, José Batista da Costa, Mohammed Baghdad, Guillermo Velilla, Igor Nunes-Silva, Sebastien Bergerat, Silvia Garcia-Barreras, François Rozet, Alexandre Ingels, Marc Galiano, Rafael Sanchez-Salas, Eric Barret, Xavier Cathelineau
INTRODUCTION AND OBJECTIVE: Focal cryotherapy emerged as an efficient option to treat favorable and localized prostate cancer (PCa). The purpose of this video is to describe the procedure step by step. MATERIALS AND METHODS: We present the case of a 68 year-old man with localized PCa in the anterior aspect of the prostate. RESULTS: The procedure is performed under general anesthesia, with the patient in lithotomy position. Briefly, the equipament utilized includes the cryotherapy console coupled with an ultrasound system, argon and helium gas bottles, cryoprobes, temperature probes and an urethral warming catheter...
July 20, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28717259/a-computerized-tutor-prototype-for-prostate-cryotherapy-key-building-blocks-and-system-evaluation
#9
Yoed Rabin, Kenji Shimada, Purva Joshi, Anjali Sehrawat, Robert Keelan, Dona M Wilfong, James T McCormick
This paper focuses on the evaluation of a prototype for a computer-based tutoring system for prostate cryosurgery, while reviewing its key building blocks and their benchmark performance. The tutoring system lists geometrical constraints of cryoprobe placement, displays a rendered shape of the prostate, simulates cryoprobe insertion, enables distance measurements, simulates the corresponding thermal history, and evaluates the mismatch between the target region shape and a pre-selected planning isotherm. The quality of trainee planning is measured in comparison with a computer-generated plan, created for each case study by a previously developed planning algorithm, known as bubble-packing...
January 28, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28679177/cryotherapy-for-low-risk-prostate-cancer-oncological-and-functional-medium-term-outcomes-a-three-center-prospective-study
#10
Valerian Ciprian Lucan, Franco Lugnani, Salvatore Butticè, Emre Sener, Christopher Netsch, Michele Talso, Francesco Cantiello, Rosa Pappalardo, Carlo Magno
OBJECTIVES: Analyze the oncologic and functional outcomes in patients affected by low risk prostate cancer underwent prostate cryotherapy. Materiasl and methods: It's a prospective tricentric study of 434 patients treated with prostate cryoablation for low risk prostate cancer. By low risk we refer to the D'Amico's risk classification. Two cycles of freezing/thawing are run for each patient following the technique described by Onik. RESULTS: For the 434 patients, the median age was 66 years with a standard deviation of ± 6...
June 30, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28656131/iatrogenic-bleeding-during-flexible-bronchoscopy-risk-factors-prophylactic-measures-and-management
#11
REVIEW
Maurizio Bernasconi, Coenraad F N Koegelenberg, Angela Koutsokera, Adam Ogna, Alessio Casutt, Laurent Nicod, Alban Lovis
Significant iatrogenic bleeding during flexible bronchoscopy is fortunately rare and usually self-limiting. Life-threatening bleeding, however, can occur, especially after conventional or cryoprobe-assisted transbronchial biopsy. The aim of this review is to provide the practising pulmonologist with a concise overview of the incidence, severity and risk factors for bleeding, to provide sensible advice on prophylactic measures and to suggest a plan of action in the case of significant bleeding. Bronchoscopy units should have a standardised approach and plan of action in the case of life-threatening haemorrhage...
April 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28652159/skin-to-tumor-distance-predicts-treatment-failure-of-t1a-renal-cell-carcinoma-following-percutaneous-cryoablation
#12
Simone L Vernez, Zhamshid Okhunov, Kamaljot Kaler, Ramy F Youssef, Rahul Dutta, Arkadiy Palvanov, Paras Shah, Kathryn Osann, David N Siegel, Igor Lobko, Louis Kavoussi, Ralph V Clayman, Jaime Landman
OBJECTIVE: To determine the impact of skin-to-tumor (STT) distance on the risk for treatment failure following percutaneous cryoablation (PCA). METHODS: We retrospectively reviewed patients who underwent PCA with documented T1a recurrent renal cell carcinoma (RCC) at 2 academic centers between 2005 and 2015. Patient demographics, tumor characteristics, and perioperative and postoperative course variables were collected. Additionally, we measured the STT distance by averaging the distance from the skin to the center of the tumor at 0°, 45°, and 90° on preoperative computed tomography imaging...
June 23, 2017: Urology
https://www.readbyqxmd.com/read/28593055/a-surgical-cryoprobe-for-targeted-transcorneal-freezing-and-endothelial-cell-removal
#13
Alina Akhbanbetova, Shinichiro Nakano, Stacy L Littlechild, Robert D Young, Madara Zvirgzdina, Nigel J Fullwood, Ian Weston, Philip Weston, Shigeru Kinoshita, Naoki Okumura, Noriko Koizumi, Andrew J Quantock
PURPOSE: To examine the effects of transcorneal freezing using a new cryoprobe designed for corneal endothelial surgery. METHODS: A freezing console employing nitrous oxide as a cryogen was used to cool a series of different cryoprobe tip designs made of silver for high thermal conductivity. In vitro studies were conducted on 426 porcine corneas, followed by preliminary in vivo investigations on three rabbit corneas. RESULTS: The corneal epithelium was destroyed by transcorneal freezing, as expected; however, the epithelial basement membrane remained intact...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28580148/post-tuberculosis-mycetoma-bronchoscopic-removal
#14
Liam J Chawke, Eoin B Hunt, Marcus P Kennedy, Desmond M Murphy
A 76-year-old male non-smoker presented to our institution with cough and haemoptysis. He had been treated for cavitatory pulmonary Mycobacterium tuberculosis of the right upper lobe 10 years previously. Chest radiograph and subsequent computed tomography (CT) of the chest demonstrated a right upper cavity containing a mass suspicious for mycetoma. Flexible bronchoscopy under conscious sedation demonstrated a mass obstructing the anterior segment of the right upper lobe. The abnormality was subsequently removed using a flexible endobronchial cryoprobe...
July 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28558164/advanced-solvent-signal-suppression-for-the-acquisition-of-1d-and-2d-nmr-spectra-of-scotch-whisky
#15
Will Kew, Nicholle G A Bell, Ian Goodall, Dušan Uhrín
A simple and robust solvent suppression technique that enables acquisition of high-quality 1D (1) H nuclear magnetic resonance (NMR) spectra of alcoholic beverages on cryoprobe instruments was developed and applied to acquire NMR spectra of Scotch Whisky. The method uses 3 channels to suppress signals of water and ethanol, including those of (13) C satellites of ethanol. It is executed in automation allowing high throughput investigations of alcoholic beverages. On the basis of the well-established 1D nuclear Overhauser spectroscopy (NOESY) solvent suppression technique, this method suppresses the solvent at the beginning of the pulse sequence, producing pure phase signals minimally affected by the relaxation...
May 30, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/28543277/experimental-study-of-cryofreezing-energy-applications-on-the-ventricular-myocardium-using-sheep-hearts
#16
Kaoru Okishige, Peter L Friedman
BACKGROUND: Cryofreezing energy has been utilized to abolish arrhythmogenic substrates of various kinds of tachyarrhythmias. However, systematic electrophysiological and histological investigations of cryothermia have never been performed. The aim of this study was to clarify those aspects using sheep beating hearts. METHODS: A total of eight adult sheep were utilized under total anesthesia, and a pericardial cradle was made by opening the pericardium. Eight epicardial plaque electrodes were sutured on the epicardial surface of the left ventricle 2∼3 cm apart from each other...
August 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28514898/assessment-of-cryosurgical-device-performance-using-a-3d-tissue-engineered-cancer-model
#17
John M Baust, Anthony Robilotto, Kristi K Snyder, Kimberly Santucci, Jennie Stewart, Robert Van Buskirk, John G Baust
As the clinical use of cryoablation for the treatment of cancer has increased, so too has the need for knowledge on the dynamic environment within the frozen mass created by a cryoprobe. While a number of factors exist, an understanding of the iceball size, critical isotherm distribution/penetration, and the resultant lethal zone created by a cryoprobe are critical for clinical application. To this end, cryoprobe performance is typically characterized based on the iceball size and temperature penetration in phantom gel models...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28412936/-1-h-nmr-analysis-of-feces-new-possibilities-in-the-helminthes-infections-research
#18
Sarantos Kostidis, Daria Kokova, Natalia Dementeva, Irina V Saltykova, Hye Kyong Kim, Young Hae Choi, Oleg A Mayboroda
BACKGROUND: Analysis of the stool samples is an essential part of routine diagnostics of the helminthes infections. However, the standard methods such Kato and Kato-Katz utilize only a fraction of the information available. Here we present a method based on the nuclear magnetic resonance spectroscopy (NMR) which could be auxiliary to the standard procedures by evaluating the complex metabolic profiles (or phenotypes) of the samples. METHOD: The samples were collected over the period of June-July 2015, frozen at -20 °C at the site of collection and transferred within four hours for the permanent storage at -80 °C...
April 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28353119/safety-and-feasibility-of-pleural-cryobiopsy-compared-to-forceps-biopsy-during-semi-rigid-pleuroscopy
#19
Vikas Pathak, Ray W Shepherd, Ehab Hussein, Rajiv Malhotra
BACKGROUND: Pleural biopsy is often obtained in patients with undiagnosed exudative pleural effusion during pleuroscopy. Standard forceps have been traditionally used for the biopsy. Cryoprobes are being increasingly used for transbronchial lung biopsy as they obtain larger specimens and have less crush artifact. However, the safety and feasibility of cryoprobe biopsy compared to standard forceps for pleural biopsy has not been fully assessed. OBJECTIVES: The objective of this study was to demonstrate the safety and feasibility of cryoprobe biopsy in the pleural space using semi-rigid pleuroscopy...
June 2017: Lung
https://www.readbyqxmd.com/read/28323734/radial-probe-ultrasound-guided-cryobiopsy
#20
Ilya G Berim, Ali I Saeed, Ahmed Awab, Adam Highley, Agnes Colanta, Fawad Chaudry
Fluoroscopy-guided transbronchial forceps biopsy has a low diagnostic yield in patients with radiographic suspicion of interstitial lung disease. Cryobiopsy has a higher diagnostic yield likely due to preserved lung architecture and larger biopsies; however, there is an increased risk of major airway bleeding and pneumothorax. Simultaneous use of endobronchial balloon blocker allows for containment of bleeding after cryobiopsy to the affected lobe. In the current article we describe use of radial ultrasound in identification of a target lung parenchyma without a major blood vessel adjacent to distal bronchi...
April 2017: Journal of Bronchology & Interventional Pulmonology
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