keyword
https://read.qxmd.com/read/38492447/noise-sensitivity-or-hyperacusis-comparing-the-weinstein-and-khalfa-questionnaires-in-a-community-and-a-clinical-samples
#21
REVIEW
Charlotte Bigras, Sarah M Theodoroff, Emily J Thielman, Sylvie Hébert
Noise sensitivity and hyperacusis are decreased sound tolerance conditions that are not well delineated or defined. This paper presents the correlations and distributions of the Noise Sensitivity Scale (NSS) and the Hyperacusis Questionnaire (HQ) scores in two distinct large samples. In Study 1, a community-based sample of young healthy adults (n = 103) exhibited a strong correlation (r = 0.74) between the two questionnaires. The mean NSS and HQ scores were 54.4 ± 16.9 and 12.5 ± 7.5, respectively...
March 8, 2024: Hearing Research
https://read.qxmd.com/read/38492350/evaluation-of-treatment-outcomes-and-tolerability-in-older-patients-with-rectal-cancer-treated-with-radiotherapy-accompanied-by-the-g-8-geriatric-score-trod13-003-multicenter-study
#22
JOURNAL ARTICLE
Zeliha Güzelöz, İlknur Bilkay Görken, Barbaros Aydın, Fatma Sert, Deniz Yalman, Murtaza Parvizi, Gülhan Güler Avcı, Pelin Altınok, Hatice Halis, Şefika Arzu Ergen, Züleyha Akgün, Elif Özkan, Yıldız Güney, Didem Karaçetin, Nuri Kaydıhan, Mürsel Düzova, Murat Akın, Bora Uysal, Mihriban Erdoğan, Hülya Ellidokuz, Gamze Aksu, Evrim Metcalfe
INTRODUCTION: The choice of treatment for rectal cancer often differs in older and younger patients, with the rate of radiotherapy use lower among older adults. In our daily practice, when evaluating a frail older patient with rectal cancer, we usually choose to give less treatment. This may be due to concern that the patient will not be able to tolerate radiotherapy. The Geriatric 8 score (G8GS) is a guide to evaluating treatment tolerability as it relates to frailty in older adults with cancer...
March 15, 2024: Journal of Geriatric Oncology
https://read.qxmd.com/read/38492159/environmental-interventions-for-preventing-atopic-diseases
#23
REVIEW
Scott Pfirrman, Ashley Devonshire, Andrew Winslow
PURPOSE OF REVIEW: In this review, we detail the exposome (consisting of environmental factors such as diet, microbial colonization, allergens, pollutants, and stressors), mechanistic and clinical research supporting its influence on atopic disease, and potentiation from climate change. We highlight contemporary environmental interventions and available evidence substantiating their roles in atopic disease prevention, from observational cohorts to randomized controlled trials, when available...
March 16, 2024: Current Allergy and Asthma Reports
https://read.qxmd.com/read/38492114/improved-survival-over-time-with-immunotherapy-in-locally-advanced-and-metastatic-cutaneous-squamous-cell-carcinomas
#24
JOURNAL ARTICLE
Sophie Schneider, Thomas Ferte, Océane Ducharme, Léa Dousset, Sorilla Prey, Caroline Dutriaux, Emilie Gerard, Marie Beylot-Barry, Anne Pham-Ledard
PURPOSE: Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer in white-skinned populations. There is little information on the epidemiology of cSCC, and even less on advanced cases (acSCC). Therefore, we analyzed acSCC patients to describe their characteristics, management, and outcomes over time. METHODS: A single-center retrospective study was conducted over a period of 5 years, including all patients who started systemic therapy for acSCC...
March 16, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38491947/diet-composition-and-sterilization-modifies-intestinal-microbiome-diversity-and-burden-of-theiler-s-virus-infection-induced-acute-seizures
#25
JOURNAL ARTICLE
Dannielle K Zierath, Stephanie Davidson, Jonathan Manoukian, Kevin M Knox, H Steve White, Stacey Meeker, Aaron Ericsson, Melissa Barker-Haliski
OBJECTIVE: Brain infection with Theiler's murine encephalomyelitis virus (TMEV) in C57BL/6J mice can induce acquired epileptogenesis. Diet alters acute seizure incidence in TMEV-infected mice; yet it is unclear whether intestinal dysbiosis may also impact acute or chronic behavioral comorbidities. This study thus assessed the impact of diet formulation and sterilization on acute seizure presentation, gut microbiome composition, and epilepsy-related chronic behavioral comorbidities. METHODS: Baseline fecal samples were collected from male C57BL/6J mice (4- to 5-weeks-old; Jackson Labs) upon facility arrival...
March 16, 2024: Epilepsia
https://read.qxmd.com/read/38491907/how-can-current-oncological-datasets-be-adjusted-to-support-the-automated-patient-recruitment-in-clinical-trials
#26
JOURNAL ARTICLE
Maria-Luisa Marino, Lara Kazmaier, Antonia Krendelsberger, Silvia Müller, Sabine Kesting, Theres Fey, Daniel Nasseh
OBJECTIVES: This study aims to identify necessary adjustments required in existing oncological datasets to effectively support automated patient recruitment. METHODS: We extracted and categorized the inclusion and exclusion criteria from 115 oncological trials registered on ClinicalTrials.gov in 2022. These criteria were then compared with the content of the oBDS (Oncological Base Dataset version 3.0), Germany's legally mandated oncological data standard. RESULTS: The analysis revealed that 42...
2024: Health Informatics Journal
https://read.qxmd.com/read/38491774/can-nondisplacement-osteoporotic-pubic-rami-fracture-be-life-threatening-injuries-a-case-report-overview-and-algorithm-protocol-for-management
#27
JOURNAL ARTICLE
Grigorios Kastanis, Anna Pantouvaki, Mikela-Rafaella Siligardou, Constantinos Chaniotakis, Emmanouil Kroustalakis, Ioannis Stavrakakis, Petros Kapsetakis
Pubic rami fractures in the geriatric population are usually osteoporotic fractures resulting from low energy trauma and are characterized as stable injuries. Established treatment of these injuries is conservative, including rest, analgesic medication, and progressive active mobilization. These injuries are life-threatened when pubic rami fractures are accompanied by acute bleeding, either from an injury to a vessel (corona mortis) or from medication (anticoagulant or antiplatelet) for comorbidities, then...
2024: Journal of Investigative Medicine High Impact Case Reports
https://read.qxmd.com/read/38491736/real-life-data-over-36%C3%A2-weeks-of-guselkumab-treatment-in-psoriasis-patients-a-single-center-study-from-turkey
#28
JOURNAL ARTICLE
Eda Öksüm Solak, Fatih Can Aba, Salih Levent Çınar, Demet Kartal, Murat Borlu
BACKGROUND: Psoriasis is an important health problem responsible for morbidity and workforce loss. In recent years, anti-IL-23 drugs have become essential in psoriasis treatment. OBJECTIVES: This study aimed to investigate the efficacy and safety of guselkumab therapy, recently used in Turkey, by examining real-life data over 36 weeks. METHODS: A total of 39 psoriasis patients (>18 years old) who received guselkumab treatment between December 2021 and December 2022 in the dermatology department of our hospital were included in the study...
March 15, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38491733/use-of-medication-in-pregnancy-on-the-rise-study-on-1-4%C3%A2-million-danish-pregnancies-from-1998-to-2018
#29
JOURNAL ARTICLE
Mette Østergaard Thunbo, Julie Hauer Vendelbo, Daniel R Witte, Agnete Larsen, Lars Henning Pedersen
INTRODUCTION: Maternal demographics have evolved, and more women than ever enter pregnancy with preexisting comorbidity and with potentially complex medication exposure, including polypharmacy (concomitant intake of multiple medications). This study aims to describe the evolution of medication use in pregnancy in Denmark from 1998 to 2018 with special focus on polypharmacy, patterns of use, and underlying demographics. MATERIAL AND METHODS: A Danish nationwide historical registry study based on all clinically recognized pregnancies with a gestation ≥10 weeks between 1998 and 2018...
March 15, 2024: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/38491725/retrospective-study-to-compare-the-effectiveness-of-minimally-invasive-microscopic-unilateral-laminotomy-with-microscopic-bilateral-laminotomy-for-bilateral-decompression-in-the-early-postoperative-period-in-142-patients-with-single-level-lumbar-spinal-stenosis
#30
JOURNAL ARTICLE
Bülent Gülensoy, Serkan Şimşek
BACKGROUND We aimed to compare the effectiveness of microscopic unilateral laminotomy for bilateral decompression (ULBD) and microscopic bilateral laminotomy for bilateral decompression (BLBD) in the early postoperative period among patients with single-level lumbar spinal stenosis (LSS). MATERIAL AND METHODS A retrospective cohort study was conducted on patients with LSS who underwent ULBD or BLBD between January 2020 and December 2023, including 94 patients who underwent ULBD and 58 who underwent BLBD. Patient demographics, comorbidities, smoking status, and data related to LSS were reviewed...
March 16, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/38491543/a-retrospective-study-exploring-preoperative-hyponatremia-in-elderly-patients-with-hip-fractures
#31
JOURNAL ARTICLE
Li-Tao Shi, Zhen Feng, Cui-Min Zhu
BACKGROUND: This research aims to examine the frequency, age-related distribution, and intensity of preoperative hyponatremia among elderly individuals with hip fractures. This study aims to provide valuable insights into the diagnosis of preoperative hyponatremia in this patient population. METHODS: This research involved the analysis of clinical data obtained from 419 elderly individuals with hip fractures (referred to as the fracture group) and 166 elderly individuals undergoing routine health examinations (designated as the control group)...
March 16, 2024: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/38491526/the-spleen-is-the-graveyard-of-cd4-cells-in-patients-with-immunological-failure-of-visceral-leishmaniasis-and-aids
#32
JOURNAL ARTICLE
Luis Gustavo Cavalcante Reinaldo, Raimundo José Cunha Araújo Júnior, Thiago Melo Diniz, Rafael de Deus Moura, Antônio José Meneses Filho, Caio Victor Verçosa de Macedo Furtado, Washington Luis Conrado Dos Santos, Dorcas Lamounier Costa, Kelsen Dantas Eulálio, Gabriel R Ferreira, Carlos Henrique Nery Costa
BACKGROUND: Visceral leishmaniasis (VL), or kala-azar, is a common comorbidity in patients with AIDS in endemic areas. Many patients continue to experiences relapses of VL despite virological control, but with immunological failure. These patients remain chronically symptomatic with hypersplenism, for example with anemia, leukopenia, and thrombocytopenia, and are at risk of severe co-infection due to low CD4+ count. Therefore, in this study, splenectomized patients with VL and HIV infection were investigated to understand why the CD4+ count fails to recover in these patients, evaluating the importance of spleen mass for hypersplenism and immunological failure...
March 15, 2024: Parasites & Vectors
https://read.qxmd.com/read/38491509/comparison-of-the-yield-of-two-tuberculosis-screening-approaches-among-household-contacts-in-a-community-setting-of-silti-zone-central-ethiopia-a-prospective-cohort-study
#33
JOURNAL ARTICLE
Habtamu Milkias Wolde, Betselot Zerihun, Waganeh Sinshaw, Delenasaw Yewhalaw, Gemeda Abebe
BACKGROUND: Household contacts of tuberculosis (TB) patients are at a greater risk of infection and developing TB as well. Despite recommendations to actively screen such high-risk groups for TB, it is poorly implemented in Ethiopia. A community-based household contact screening was conducted to compare the yield of two different screening approaches and to identify factors associated with TB occurrence. METHODS: Smear-positive pulmonary TB index cases from six health facilities in six districts of Silti Zone were identified and enrolled prospectively between September 2020 and December 2022...
March 15, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38491506/clinical-characteristics-and-outcome-of-lung-cancer-in-patients-with-fibrosing-interstitial-lung-disease
#34
JOURNAL ARTICLE
Soo Jin Han, Hyeon Hwa Kim, Dong-Gon Hyun, Wonjun Ji, Chang-Min Choi, Jae Cheol Lee, Ho Cheol Kim
BACKGROUND: Lung cancer (LC) is an important comorbidity of interstitial lung disease (ILD) and has a poor prognosis. The clinical characteristics and outcome of each ILD subtype in LC patients have not been sufficiently investigated. Therefore, this study aimed to evaluate the difference between idiopathic pulmonary fibrosis (IPF) and non-IPF ILD as well as prognostic factors in patients with ILD-LC. METHODS: The medical records of 163 patients diagnosed with ILD-LC at Asan Medical Center from January 2018 to May 2023 were retrospectively reviewed...
March 15, 2024: BMC Pulmonary Medicine
https://read.qxmd.com/read/38491478/the-impact-of-multimorbidity-among-adults-with-cardiovascular-diseases-on-healthcare-costs-in-indonesia-a-multilevel-analysis
#35
JOURNAL ARTICLE
Royasia Viki Ramadani, Mikael Svensson, Sven Hassler, Budi Hidayat, Nawi Ng
BACKGROUND: Cardiovascular diseases (CVDs) are the leading cause of death in Indonesia, accounting for 38% of the total mortality in 2019. Moreover, healthcare spending on CVDs has been at the top of the spending under the National Health Insurance (NHI) implementation. This study analyzed the association between the presence of CVDs with or without other chronic disease comorbidities and healthcare costs among adults (> 30 years old) and if the association differed between NHI members in the subsidized group (poorer) and non-subsidized households group (better-off) in Indonesia...
March 15, 2024: BMC Public Health
https://read.qxmd.com/read/38491434/utilizing-the-national-early-warning-score-2-news2-to-confirm-the-impact-of-emergency-department-management-in-sepsis-patients-a-cohort-study-from-taiwan-1998-2020
#36
JOURNAL ARTICLE
Ming-Shun Hsieh, Kuan-Chih Chiu, Amrita Chattopadhyay, Tzu-Pin Lu, Shu-Hui Liao, Chia-Ming Chang, Yi-Chen Lee, Wei-En Lo, Vivian Chia-Rong Hsieh, Sung-Yuan Hu, Chorng-Kuang How
BACKGROUND: Most sepsis patients could potentially experience advantageous outcomes from targeted medical intervention, such as fluid resuscitation, antibiotic administration, respiratory support, and nursing care, promptly upon arrival at the emergency department (ED). Several scoring systems have been devised to predict hospital outcomes in sepsis patients, including the Sequential Organ Failure Assessment (SOFA) score. In contrast to prior research, our study introduces the novel approach of utilizing the National Early Warning Score 2 (NEWS2) as a means of assessing treatment efficacy and disease progression during an ED stay for sepsis...
March 15, 2024: International Journal of Emergency Medicine
https://read.qxmd.com/read/38491424/the-potential-role-of-listeria-monocytogenes-in-promoting-colorectal-adenocarcinoma-tumorigenic-process
#37
JOURNAL ARTICLE
Giulia Baldelli, Mauro De Santi, Collins Njie Ateba, Giorgia Cifola, Giulia Amagliani, Christ-Donald Kaptchouang Tchatchouang, Peter Kotsoana Montso, Giorgio Brandi, Giuditta Fiorella Schiavano
BACKGROUND: Listeria monocytogenes is a foodborne pathogen, which can cause a severe illness, especially in people with a weakened immune system or comorbidities. The interactions between host and pathogens and between pathogens and tumor cells have been debated in recent years. However, it is still unclear how bacteria can interact with tumor cells, and if this interaction can affect tumor progression and therapy. METHODS: In this study, we evaluated the involvement of L...
March 15, 2024: BMC Microbiology
https://read.qxmd.com/read/38491361/dengue-encephalopathy-in-an-adult-due-to-dengue-virus-type-1-infection
#38
JOURNAL ARTICLE
Xingyu Leng, Huiqin Yang, Lingzhai Zhao, Jiamin Feng, Kanghong Jin, Lu Liao, Fuchun Zhang
BACKGROUND: Dengue is an important public health problem, which caused by the dengue virus (DENV), a single-stranded RNA virus consisted of four serotypes. Central nervus system (CNS) impairment in dengue usually results from DENV-2 or DENV-3 infection, which lead to life-threatening outcomes. Furthermore, neurological complications due to DENV-1 was rare especially in adult patients. CASE PRESENTATION: A 44-year-old man without comorbidities had lethargy after hyperpyrexia and a positive DENV NS1 antigen was detected for confirming the diagnosis of dengue on day 8 of onset...
March 15, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38491346/the-relationship-between-sarcopenia-and-metabolic-dysfunction-associated-fatty-liver-disease-among-the-young-and-middle-aged-populations
#39
JOURNAL ARTICLE
Ziyan Feng, Fanrong Zhao, Ziyao Wang, Xinyi Tang, Yan Xie, Li Qiu
BACKGROUND: Metabolic dysfunction-associated fatty liver disease (MAFLD) has been proposed as a new term for diagnosing fatty liver disease, which is considered to be a multi-systemic disease with multiple extrahepatic manifestations, including sarcopenia. The link between sarcopenia and MAFLD remains uncertain, especially among young and middle-aged adults. Thus, we examined the relationship between MAFLD and sarcopenia in young and middle-aged individuals in this study. METHODS: A total of 2214 individuals with laboratory tests, dual-energy X-ray absorptiometry and ultrasound transient elastography from NHANES 2017-2018 were selected for this study...
March 15, 2024: BMC Gastroenterology
https://read.qxmd.com/read/38491344/correlates-of-suicidal-behaviors-and-genetic-risk-among-united-states-veterans-with-schizophrenia-or-bipolar-i-disorder
#40
JOURNAL ARTICLE
Tim B Bigdeli, Peter B Barr, Nallakkandi Rajeevan, David P Graham, Yuli Li, Jacquelyn L Meyers, Bryan R Gorman, Roseann E Peterson, Frederick Sayward, Krishnan Radhakrishnan, Sundar Natarajan, David A Nielsen, Anna V Wilkinson, Anil K Malhotra, Hongyu Zhao, Mary Brophy, Yunling Shi, Timothy J O'Leary, Theresa Gleason, Ronald Przygodzki, Saiju Pyarajan, Sumitra Muralidhar, J Michael Gaziano, Grant D Huang, John Concato, Larry J Siever, Lynn E DeLisi, Nathan A Kimbrel, Jean C Beckham, Alan C Swann, Thomas R Kosten, Ayman H Fanous, Mihaela Aslan, Philip D Harvey
Persons diagnosed with schizophrenia (SCZ) or bipolar I disorder (BPI) are at high risk for self-injurious behavior, suicidal ideation, and suicidal behaviors (SB). Characterizing associations between diagnosed health problems, prior pharmacological treatments, and polygenic scores (PGS) has potential to inform risk stratification. We examined self-reported SB and ideation using the Columbia Suicide Severity Rating Scale (C-SSRS) among 3,942 SCZ and 5,414 BPI patients receiving care within the Veterans Health Administration (VHA)...
March 15, 2024: Molecular Psychiatry
keyword
keyword
11347
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.