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https://www.readbyqxmd.com/read/27607910/update-on-treatment-of-cytomegalovirus-infection-in-pregnancy-and-of-the-newborn-with-congenital-cytomegalovirus
#1
William D Rawlinson, Stuart T Hamilton, Wendy J van Zuylen
PURPOSE OF REVIEW: The purpose of this review is to assess the recent studies of therapy of pregnant women and neonates, aimed at preventing the consequences of congenital cytomegalovirus (CMV) infection. RECENT FINDINGS: A recent randomized controlled trial of treatment of CMV during pregnancy with hyperimmune globulin did not show significant efficacy in prevention of foetal infection and morbidity, although there was a trend towards improvement with treatment...
December 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27599330/association-between-mri-exposure-during-pregnancy-and-fetal-and-childhood-outcomes
#2
Joel G Ray, Marian J Vermeulen, Aditya Bharatha, Walter J Montanera, Alison L Park
IMPORTANCE: Fetal safety of magnetic resonance imaging (MRI) during the first trimester of pregnancy or with gadolinium enhancement at any time of pregnancy is unknown. OBJECTIVE: To evaluate the long-term safety after exposure to MRI in the first trimester of pregnancy or to gadolinium at any time during pregnancy. DESIGN, SETTING, AND PARTICIPANTS: Universal health care databases in the province of Ontario, Canada, were used to identify all births of more than 20 weeks, from 2003-2015...
September 6, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27555711/multiple-ocular-and-systemic-disorders-in-association-with-bilateral-duane-s-retraction-syndrome
#3
Mohammad Ali Zare, Mohammad Reza Akbari, Mohammad Yaser Kiarudi, Hadi Zare Mehrjardi
Duane's retraction syndrome (DRS) is characterized by limitations in horizontal eye movements, globe retraction, and palpebral fissure narrowing on attempted adduction. This disorder is caused by a disturbance in innervation originating in the brain stem and represents <1% of all cases of strabismus. It is postulated that this syndrome is due to an insult during the early weeks (8-10 weeks) of pregnancy and is 10-20 times more frequently associated with other systemic congenital anomalies. This case report of bilateral DRS included bilateral iris-retinal coloboma and congenital heart disease, sensory hearing loss, and inguinal hernia...
July 2016: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/27351041/-intrauterine-infections-as-a-risk-factor-of-the-development-of-sensorineural-impairment-of-hearing
#4
REVIEW
M Yu Boboshko, S M Vikhnin, I V Savenko
Intrauterine infections are a crucial pathogenic factor exerting an appreciable influence on the development of the fetus. They can provoke intrauterine death, cause multiple lesions in the organs and tissues as well as long-term complications that manifest themselves at the later stages of the growth and development of the child. One of such complications is the sensorineural loss of hearing. The importance of hearing impairment arises from the high prevalence of tis condition and frequent incapacitation it causes in the patients...
2016: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/27114380/clinical-implications-for-children-born-with-congenital-cytomegalovirus-infection-following-a-negative-amniocentesis
#5
Efraim Bilavsky, Joseph Pardo, Joseph Attias, Itzhak Levy, Jean-François Magny, Yves Ville, Marianne Leruez-Ville, Jacob Amir
BACKGROUND: Recently, congenital cytomegalovirus (cCMV) infection was reported irrespective of a negative amniotic fluid prenatal analysis for cytomegalovirus (CMV). The question of whether this phenomenon represents low sensitivity of the test or late development of fetal infection (after amniocentesis) was discussed, but not answered. However, if late transmission is the rule, then infants born with cCMV after negative amniocentesis would be expected to carry better prognosis than those who tested positive...
July 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27109325/-can-men-be-included-in-the-population-subjected-to-puerperal-psychosis-a-case-report
#6
M Colombel, C Rebillard, C Nathou, S Dollfus
INTRODUCTION: Puerperal psychosis (PP) is a psychiatric disorder that occurs in 1 out of 1000 pregnancies. Well known since antiquity, its symptoms have often been described in mothers, but few studies have successfully investigated a related disorder in fathers. The characteristic of this pathology is more related to its appearance than to its semiological description which is why its nosographic place is always discussed. The objective here is to focus on the definition of PP and to suggest an entity for both genders...
August 2016: L'Encéphale
https://www.readbyqxmd.com/read/27052963/pregnancy-is-not-a-risk-factor-for-idiopathic-sudden-sensorineural-hearing-loss-a-nationwide-population-based-study
#7
Ting-Ting Yen, Ching-Heng Lin, Jiun-Yih Shiao, Kai-Li Liang
CONCLUSION: Sudden sensorineural hearing loss (SSNHL) in pregnancy is rare. It usually occurs in the third trimester. SSNHL in pregnancy does not increase risks during delivery or subsequent stroke. OBJECTIVES: This study aimed to investigate the incidence and to determine the factors associated with SSNHL in pregnancy. METHOD: Data were retrieved from Taiwan's National Health Insurance Database (NHIRD), covering the years 2000-2009. Patients admitted for SSNHL during pregnancy were enrolled...
2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/26978745/-the-evaluation-of-the-hearing-function-in-the-premature-infants-with-intrauterine-growth-retardation-during-the-third-and-sixth-months-of-life-by-recording-auditory-steady-state-response
#8
I V Rakhmanova, I N D'yakonova, L G Sichinava, Yu A Ledovskikh
The objective of the present work was to study the function of the retrocochlear auditory pathway in the premature infants with intrauterine growth retardation (IGR) in comparison to that of the normotrophics of a similar gestational age during the third and sixth months of life by recording auditory steady-state responses (ASSR). The audiological examination by the method of auditory steady-state response (ASSR) involved 127 children at the 3d month of life and in 97 children at the 6th month of life. It was shown that the ASSR thresholds at certain frequencies during the 3d and 6th months of life of the children born after the 32d week of pregnancy were significantly higher than in the children born after 32 weeks gestation...
2015: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/26897139/noise-as-a-health-hazard-for-children-time-to-make-a-noise-about-it
#9
Neha Thakur, Prerna Batra, Piyush Gupta
Noise, a modern day curse of advancing infrastructure and technology, has emerged as an important public health problem. Exposure to noise during pregnancy may result in high-frequency hearing loss in newborns, growth retardation, cochlear damage, prematurity and birth defects. Newborns exposed to sound above 45 decibels may experience increase in blood pressure, heart rate, respiratory rate; decreased oxygen saturation; and increased caloric consumption. Noise exposure in older children may result in learning disabilities, attention difficulties, insulin resistance, hypertension, stress ulcers and cardiovascular diseases...
February 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/26808779/identification-of-symptomatic-fetuses-infected-with-cytomegalovirus-using-amniotic-fluid-peptide-biomarkers
#10
Cyrille Desveaux, Julie Klein, Marianne Leruez-Ville, Adela Ramirez-Torres, Chrystelle Lacroix, Benjamin Breuil, Carine Froment, Jean-Loup Bascands, Joost P Schanstra, Yves Ville
Cytomegalovirus (CMV) is the most common cause of congenital infection, and is a major cause of sensorineural hearing loss and neurological disabilities. Evaluating the risk for a CMV infected fetus to develop severe clinical symptoms after birth is crucial to provide appropriate guidance to pregnant women who might have to consider termination of pregnancy or experimental prenatal medical therapies. However, establishing the prognosis before birth remains a challenge. This evaluation is currently based upon fetal imaging and fetal biological parameters, but the positive and negative predictive values of these parameters are not optimal, leaving room for the development of new prognostic factors...
January 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/26753416/-surrogate-pregnancy-with-regard-to-marriage-between-persons-of-the-same-sex
#11
REVIEW
Roger Henrion
After first defining surrogacy, distinguishing between cases in which the pregnancy results from the surrogate's own egg or a donor egg, and examining the different configurations of male homosexual families, the authors outline French and foreign legislation and provide a summary of the literature and of French working group hearings. Arguments for and against lifting the ban on surrogacy for gay couples are examined. The main arguments for lifting the ban are the following: 1) the same-sex couple's desire to start a family from their own gene pool, 2) current obstacles to adoption, 3) the notion of equality between heterosexual and homosexual couples, 4) frequent recourse to surrogacy abroad, which is not only very costly but also leaves the child in a state of legal limbo on its return to France, and 5) the lack of access to therapeutic alternatives...
April 2014: Bulletin de L'Académie Nationale de Médecine
https://www.readbyqxmd.com/read/26591303/-newborn-screening-the-point-of-view-of-the-paediatrician
#12
REVIEW
C De Laet, H Laeremans, A Ferster, B Gulbis, A-L Mansbach, E Jonniaux, L Regal, P Goyens
Newborn screening is a public health effort that has changed the prognosis of some congenital diseases. Newborn screening programmes differ between countries in which it is organized. Demographic, epidemiological or economic factors play a role in the choice of the screening panel. In the French Community of Belgium, the programme focuses on 13 metabolic and endocrine diseases, hearing loss and hemoglobinopathies (Brussels and Liege). Newborn screening is a complex process that requires the involvement of all stakeholders : parent information, blood sampling or testing, lab analysis, follow-up of the results, initiate adequate care in case of positive test and genetic counselling...
September 2015: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/26432548/reproductive-management-through-integration-of-pgd-and-mps-based-noninvasive-prenatal-screening-diagnosis-for-a-family-with-gjb2-associated-hearing-impairment
#13
WenPing Xiong, DaYong Wang, Yuan Gao, Ya Gao, HongYang Wang, Jing Guan, Lan Lan, JunHao Yan, Liang Zong, Yuan Yuan, Wei Dong, SeXin Huang, KeLiang Wu, YaoShen Wang, ZhiLi Wang, HongMei Peng, YanPing Lu, LinYi Xie, Cui Zhao, Li Wang, QiuJing Zhang, Yun Gao, Na Li, Ju Yang, ZiFang Yin, Bing Han, Wei Wang, Zi-Jiang Chen, QiuJu Wang
A couple with a proband child of GJB2 (encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis (PGD), noninvasive prenatal testing (NIPT), and noninvasive prenatal diagnosis (NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations...
September 2015: Science China. Life Sciences
https://www.readbyqxmd.com/read/26382941/maternal-associated-factors-of-low-birth-weight-a-hospital-based-cross-sectional-mixed-study-in-tigray-northern-ethiopia
#14
Meresa Gebremedhin, Fentie Ambaw, Eleni Admassu, Haileselassie Berhane
BACKGROUND: Birth weight is an important determinant of child survival and development. So far, the prevalence and traditional maternal feeding practice correlates of low birth weight have not been explored well in Ethiopia. Therefore, the purpose of this study was to determine the prevalence and associated factors of low birth weight among mothers who delivered at governmental hospitals, Northern, Ethiopia. METHODS: A cross-sectional mixed study design was carried out in 3 zonal hospitals among 308 mothers and their respective live born baby consecutively using interviewer administered piloted questionnaire and 3 focus group discussions were conducted for the qualitative part...
September 17, 2015: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/26255986/cohort-study-of-adult-patients-with-haemoglobin-sc-disease-clinical-characteristics-and-predictors-of-mortality
#15
Sandra F Mm Gualandro, Guilherme H H Fonseca, Iara K Yokomizo, Danielle M Gualandro, Liliana M Suganuma
Haemoglobin (Hb) SC disease is the second most common subtype of sickle cell disease and is potentially fatal. This study aimed to determine the clinical characteristics, outcome and predictors of mortality in HbSC disease patients, and to compare these findings with patients followed-up in different centres. Clinical, laboratory and outcome data were collected from a cohort of adult patients with HbSC disease followed between 1991 and 2103. Cox regression multivariate analysis was used to determine predictors of mortality...
November 2015: British Journal of Haematology
https://www.readbyqxmd.com/read/26251359/global-burden-of-genetic-disease-and-the-role-of-genetic-screening
#16
REVIEW
I C Verma, R D Puri
It is estimated that 5.3% of newborns will suffer from a genetic disorder, when followed up until the age of 25 years. In developing, as compared to western countries, hemoglobinopathies and glucose-6-phosphate dehydrogenase deficiency have a higher incidence due to severe falciparum malaria in the distant past, and autosomal recessive disorders have a higher frequency due to greater proportion of consanguineous marriages. Chromosomal disorders have a combined frequency of 1 in 153 births, therefore screening for chromosomal disorders is essential, using biochemical markers, ultrasonography, and recently by non-invasive prenatal diagnosis based on cell-free fetal DNA in maternal plasma...
October 2015: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26195624/antenatal-factors-modulate-hearing-screen-failure-risk-in-preterm-infants
#17
Jocelyn C Leung, Christina L Cifra, Alexander G Agthe, Chen-Chih J Sun, Rose M Viscardi
OBJECTIVE: The objective of this study was to characterise the effects of antenatal inflammatory factors and maternal therapies on neonatal hearing screen outcomes in very low birthweight infants. METHODS: We conducted a retrospective study of a cohort of infants <33 weeks' gestational age and <1501 g birth weight prospectively enrolled between 1999 and 2003 for whom placental pathology, cord blood interleukin (IL) 6, IL-1ß, tumour necrosis factor-α and neonatal hearing screen results were available...
January 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/26078649/zekai-tahir-burak-women-s-health-education-and-research-hospital-newborn-hearing-screening-results-and-assessment-of-the-patients
#18
İstemi Han Çelik, Fuat Emre Canpolat, Gamze Demirel, Zeynep Eras, Veli Gençay Sungur, Barış Sarıer, Uğur Dilmen
AIM: Social, emotional, cognitive and language development of infants is provided with early diagnosis of hearing deficit. Hearing deficit is reported with a rate of 1-6 in 1000 live births in healthy newborns, while it reaches up to 10-30 in 1000 live births in newborns with risk factors. We aimed to compile the results of the hearing screening program applied in our hospital. MATERIAL AND METHODS: The records of the hearing screening program were examined and the results were compiled by reaching the records of the patients who were found to have hearing deficit...
June 2014: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/25996198/current-controversies-in-diagnosis-management-and-prevention-of-congenital-cytomegalovirus-updates-for-the-pediatric-practitioner
#19
Gail J Harrison
Congenital cytomegalovirus (CMV) infection has been called "the elephant in our living room" because it is a major public health problem that for decades has been unrecognized and unaddressed. Congenital CMV infection is a common cause of sensorineural hearing loss, vision loss, neurodevelopment disabilities, liver disease, and growth failure. Diagnostic tests are now widely available to identify newborns with congenital CMV infection, congenitally infected newborns now can be easily assessed for evidence of organ involvement, and there are now antiviral treatments and other interventions available to improve the outcome in children with congenital CMV disease...
May 2015: Pediatric Annals
https://www.readbyqxmd.com/read/25924667/passive-immunization-against-congenital-cytomegalovirus-infection-current-state-of-knowledge
#20
REVIEW
Julia Jückstock, Markus Rothenburger, Klaus Friese, Friederike Traunmüller
Primary infection with the human cytomegalovirus (CMV) occurs in 1-4% of pregnancies. The rates of maternal-fetal CMV transmissions are around 25, 36, 41, and 66%, for infections occurring in the peri-conceptional weeks, first, second, and third trimester of pregnancy, respectively. On the other hand, the severity of fetal organ damage and dysfunction diminishes with increasing gestational age. Congenitally CMV-infected newborns may have neurosensory impairments like mental retardation, cerebral palsy, epilepsy, progressive hearing loss or visual defects, or even may have a fatal outcome...
2015: Pharmacology
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