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https://www.readbyqxmd.com/read/29775929/negative-impacts-of-elevated-nitrate-on-physiological-performance-are-not-exacerbated-by-low-ph
#1
Daniel F Gomez Isaza, Rebecca L Cramp, Craig E Franklin
Multiple environmental stressors, including nutrient effluents (i.e. nitrates [NO3 - ]) and altered pH regimes, influence the persistence of freshwater species in anthropogenically disturbed habitats. Independently, nitrate and low pH affect energy allocation by increasing maintenance costs and disrupting oxygen uptake, which ultimately results in impacts upon whole animal performance. However, the interaction between these two stressors has not been characterised. To address this, the effects of nitrate and pH and their interaction on aerobic scope and physiological performance were investigated in the blueclaw crayfish, Cherax destructor...
May 15, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29775927/effects-of-microcystin-lr-on-the-tissue-growth-and-physiological-responses-of-the-aquatic-plant-iris-pseudacorus-l
#2
Naiyu Wang, Can Wang
The release of cyanobacterial toxins during algal bloom has adverse effects on aquatic plants and animals. This study aimed to understand the toxic effects and mechanism of microcystin-LR (MC-LR) on the seedling growth and physiological responses of Iris pseudacorus L. (calamus). After a one-month exposure experiment, the growth and development of the calamus leaves were significantly inhibited, and this inhibitory effect was verified to be concentration dependent. Furthermore, the cell membrane system was damaged, and the photosynthesis was also adversely affected by MC-LR...
April 27, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29775731/targeted-and-controlled-drug-delivery-by-multifunctional-mesoporous-silica-nanoparticles-with-internal-fluorescent-conjugates-and-external-polydopamine-and-graphene-oxide-layers
#3
Anh-Vy Tran, KyuHwan Shim, Thu-Thao Vo Thi, Jeong-Keun Kook, Seong Soo A An, Sang-Wha Lee
This study demonstrated the targeted delivery and controlled release of cisplatin drug molecules from doubly decorated mesoporous silica nanoparticles (MSNs), which were internally grafted with fluorescent conjugates and externally coated with polydopamine (PDA) and graphene oxide (GO) layers. The brush-like internal conjugates conferred fluorescent functionality and high capacity of cisplatin loading into MSNs, as well as contributing to a sustained release of the cisplatin through a porous channel with the assistance of external PDA layer...
May 15, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29775477/cryptococcus-neoformans-can-form-titan-like-cells-in-vitro-in-response-to-multiple-signals
#4
Nuria Trevijano-Contador, Haroldo Cesar de Oliveira, Rocío García-Rodas, Suélen Andreia Rossi, Irene Llorente, Ángel Zaballos, Guilhem Janbon, Joaquín Ariño, Óscar Zaragoza
Cryptococcus neoformans is an encapsulated pathogenic yeast that can change the size of the cells during infection. In particular, this process can occur by enlarging the size of the capsule without modifying the size of the cell body, or by increasing the diameter of the cell body, which is normally accompanied by an increase of the capsule too. This last process leads to the formation of cells of an abnormal enlarged size denominated titan cells. Previous works characterized titan cell formation during pulmonary infection but research on this topic has been hampered due to the difficulty to obtain them in vitro...
May 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29775047/probing-cancer-cells-through-intracellular-aggregation-induced-emission-kinetic-rate-of-copper-nanoclusters
#5
Anushree Dutta, Upashi Goswami, Arun Chattopadhyay
pH responsive luminescent copper nanoclusters (Cu NCs) with aggregation induced emission (AIE) characteristics have been synthesized. Upon internalization into living cells, the NCs displayed cellular pH environment dependent luminescence change with orange-red emission at pHi 4.5 while bright green emission was observed over time at pHi 7.4, through their AIE attributes. Further, the intracellular AIE kinetics of the NC probe was measured in MCF-7 cells and compared with HEK-293 cells. Intriguingly, intracellular rate constant value derived for AIE kinetics in MCF-7 cells was found 3-fold higher than that in HEK-293 cell lines, whereas the value was 2-fold higher than that observed in the aqueous medium...
May 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29775045/in-situ-spectroelectrochemical-monitoring-of-dye-bleaching-after-electrogeneration-of-chlorine-based-species-application-to-chloride-detection
#6
Daniel Martín-Yerga, Alejandro Pérez-Junquera, María Begoña Gonzalez-Garcia, David Hernández-Santos, Pablo Fanjul-Bolado
Spectroelectrochemical techniques are becoming increasingly versatile tools to solve a diverse range of analytical problems. Herein, the use of in situ real-time luminescence spectroelectrochemistry to quantify chloride ions is demonstrated. Utilizing the bleaching effect of chlorine-based electrogenerated products after chloride oxidation, it is shown that the fluorescence of the Rhodamine 6G dye decrease proportionally to the initial chloride concentration in solution. A strong decrease of fluorescence is observed in acidic media compared to a lower decrease in alkaline media, which suggests that Cl2 , favourably generated at low pH, could be the main species responsible of the fluorescence loss...
May 18, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29774976/stimuli-responsive-organic-dyes-with-tropylium-chromophore
#7
Demelza Lyons, Reece Crocker, Thanh Vinh Nguyen
Tropylium ions possess an interesting combination of structural stability and chemical reactivity due to its Hückel-aromaticity and its positively charged polyene nature, respectively. Herein we exploit the chemical versatility and unique structural properties of the tropylium ion to derive a family of novel 'push-and-pull' organic dyes with strong absorption in the visible range via simple and practical synthetic protocols. These stable organic dyes are highly stimuli-responsive, as demonstrated by their sensitivity towards solvent, pH change, redox reaction, Lewis base and counterion, which marks them as potentially useful compounds for opto-electronic applications...
May 18, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29774663/dual-responsive-carbon-dot-for-ph-redox-triggered-fluorescence-imaging-with-controllable-photothermal-ablation-therapy-of-cancer
#8
Cheong A Choi, Jung Eun Lee, Zihnil Adha Islamy Mazrad, Young Kwang Kim, Insik In, Ji Hoon Jeong, Sung Young Park
We described fluorescence resonance energy transfer for pH/redox-activatable fluorescent carbon dot (FNP) to realize "off-on" switched imaging-guided controllable photothermal therapy (PTT). The FNP is a carbonized self-crosslinked polymer that allows IR825 loading (FNP[IR825]) via hydrophobic interactions in cancer therapy. The capability for fluorescence bioimaging was achieved via the internalization of FNP(IR825) into tumor cells, wherein glutathione (GSH) disulfide bonds were reduced and benzoic imine were cleaved under acidic conditions...
May 18, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29773593/safety-and-efficacy-of-second-line-bosutinib-for-chronic-phase-chronic-myeloid-leukemia-over-a-five-year-period-final-results-of-a-phase-1-2-study
#9
Carlo Gambacorti-Passerini, Jorge E Cortes, Jeff H Lipton, Hagop M Kantarjian, Dong-Wook Kim, Philippe Schafhausen, Rocco Crescenzo, Nathalie Bardy-Bouxin, Mark Shapiro, Kay Noonan, Eric Leip, Liza DeAnnuntis, Tim H Brümmendorf, H Jean Khoury
Bosutinib is a Src/Abl tyrosine kinase inhibitor indicated for adults with newly-diagnosed Ph+ chronic myeloid leukemia or with resistant/intolerant disease. We report the final results of a phase 1/2 study of second-line bosutinib in chronic phase chronic myeloid leukemia patients after imatinib failure (n=284). Median follow-up and treatment durations were 54.8 (range, 0.6-96.3) and 25.6 (0.2&-96.3) months, respectively. At years 2 and 5, 54% and 40% of patients, respectively, remained on bosutinib. Cumulative major cytogenetic response and complete cytogenetic response rates (newly-attained or maintained from baseline) were 58% and 46%, respectively, by year 2 and 60% and 50% by year 5...
May 17, 2018: Haematologica
https://www.readbyqxmd.com/read/29773375/characterization-and-prebiotic-activity-in-vitro-of-inulin-type-fructan-from-codonopsis-pilosula-roots
#10
Yu-Ping Fu, Li-Xia Li, Bing-Zhao Zhang, Berit Smestad Paulsen, Zhong-Qiong Yin, Chao Huang, Bin Feng, Xing-Fu Chen, Ren-Rong Jia, Xu Song, Xue-Qin Ni, Bo Jing, Fa-Ming Wu, Yuan-Feng Zou
The inulin-type fructan was obtained by DEAE anion exchange chromatography from C. pilosula Nannf. var. modesta (Nannf.) L. T. Shen, after optimized extract condition, which was established by response surface methodology, designed using Box-Behnken factorial design and the optimum condition were: extracting 2.5 h with ratio of solvent to material 40 mL/g at 100 °C, twice. The maximum extraction yield was 20.6 ± 0.2%. It was confirmed as β-(2-1) linkage fructan, with terminal glucose, and with a degree of polymerization of 2-17 (DPav  = 6), shown by the results of methanolysis, methylation, nuclear magnetic resonance and molecular weight determination...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29773069/high-altitude-pulmonary-hypertension
#11
Maurizio Bussotti, Giovanni Marchese
The effects of hypoxia on the human organism has been considered doubly fascinating by the scientific community: the knowledge of the discrete mechanisms allowing the acclimatization both at the genetic level or through the cell mediators production in addition to the macroscopic responses of the cardio-circulatory and ventilatory systems to a hypoxic environment has been progressively developed since the last century; moreover granting a safer stay in hypoxic conditions not only for the residents but also for the different cathegories of workers, sportsmen and tourists has been considered a worthy aim of the medical activity...
May 17, 2018: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/29773004/anti-inflammatory-activity-of-chemical-constituents-isolated-from-the-willow-bracket-medicinal-mushroom-phellinus-igniarius-agaricomycetes
#12
Zhe Jiang, Mei Jin, Wei Zhou, Ren Li, Yan Zhao, Xuejun Jin, Gao Li
Nuclear factor-κB (NF-κB) has an important role in immune response and inflammation. Phellinus igniarius (known as Sang huang in traditional Chinese medicine) has various pharmacologic effects. In this study, 19 chemical constituents (1-19) were isolated from the fruiting bodies of Ph. igniarius. Their structures were elucidated based on data from nuclear magnetic resonance spectroscopy and comparison with the literature. Overall, 3 compounds (2, 7, and 11) from this species were reported, to our knowledge for the first time...
2018: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29772775/ph-responsive-mercaptoundecanoic-acid-functionalized-gold-nanoparticles-and-applications-in-catalysis
#13
Siyam M Ansar, Saptarshi Chakraborty, Christopher L Kitchens
Mercaptoundecanoic acid (MUA) functionalized gold nanoparticles (AuNP-MUA) were synthesized and demonstrated to possess pH-triggered aggregation and re-dispersion, as well as the capability of phase transfer between aqueous and organic phases in response to changes in pH. The pH of aggregation for AuNP-MUA is consistent with the pKa of MUA (pH ~4) in solution, while AuNP-MUA phase transition between aqueous and organic phases occurs at pH ~9. The ion pair formation between the amine group in octadecylamine (ODA), the carboxylate group in MUA, and the hydrophobic alkyl chain of ODA facilitates the phase transfer of AuNP-MUA into an organic medium...
May 17, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29772466/research-on-the-contamination-levels-of-norovirus-in-food-facilities-using-groundwater-in-south-korea-2015-2016
#14
Jeong Su Lee, In Sun Joo, Si Yeon Ju, Min Hee Jeong, Yun-Hee Song, Hyo Sun Kwak
Norovirus (NoV) is a major pathogenic virus that is responsible for foodborne and waterborne gastroenteritis outbreaks. Groundwater is an important source of drinking water and is used in agriculture and food manufacturing processes. This study investigated norovirus contamination of groundwater treatment systems at 1360 sites in seven metropolitan areas and nine provinces in 2015-2016. Temperature, pH, residual chlorine, and turbidity content were assessed to analyze the water quality. In 2015, six sites were positive for the presence of NoV (0...
May 11, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29772390/pathobiology-of-christianson-syndrome-linking-disrupted-endosomal-lysosomal-function-with-intellectual-disability-and-sensory-impairments
#15
Mallory Kerner-Rossi, Maria Gulinello, Steven Walkley, Kostantin Dobrenis
Christianson syndrome (CS) is a recently described rare neurogenetic disorder presenting early in life with a broad range of neurological symptoms, including severe intellectual disability with nonverbal status, hyperactivity, epilepsy, and progressive ataxia due to cerebellar atrophy. CS is due to loss-of-function mutations in SLC9A6, encoding NHE6, a sodium-hydrogen exchanger involved in the regulation of early endosomal pH. Here we review what is currently known about the neuropathogenesis of CS, based on insights from experimental models, which to date have focused on mechanisms that affect the CNS, specifically the brain...
May 14, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29772283/amphiphilic-polyurethane-hydrogels-as-smart-carriers-for-acidic-hydrophobic-drugs
#16
Lucas P Fonseca, Rafael B Trinca, Maria Isabel Felisberti
Amphiphilic hydrogels are widely reported as systems with great potential for controlled drug release. Nevertheless, the majority of studies make use of functionalization or attachment of drugs to the polymer chains. In this study, we propose a strategy of combining amphiphilic polyurethanes with pH-responsive drugs to develop smart drug carriers. While the amphiphilic character of the polymer imparts an efficient load of hydrophobic and hydrophilic drugs, the drug's characteristics determine the selectivity of the medium delivery...
May 14, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29771533/half-cell-ion-concentration-polarization-on-nafion-coated-electrode
#17
Rhokyun Kwak, Jongyoon Han
On ion selective membranes, cation/anion selective transport under electric field initiates ion concentration polarization (ICP); ion concentration increases at one side of the membrane (ion enrichment), while it decreases at the other side (ion depletion). This polarization always occurs as the pair of ion enrichment and ion depletion. Here, departing from such pair generation, we demonstrate that only half of ICP (either ion enrichment or ion depletion) can be solitary on a Nafion-coated electrode. Current-voltage-time responses and conductance measurement capture this half-cell ICP with qualitative in situ pH / ion concentration visualization...
May 17, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29771502/atmospheric-co2-enrichment-and-reactive-nitrogen-inputs-interactively-stimulate-soil-cation-losses-and-acidification
#18
Li Zhang, Yunpeng Qiu, Lei Cheng, Yi Wang, Lingli Liu, Cong Tu, Dan C Bowman, Kent O Burkey, Xinmin Bian, Weijian Zhang, Shuijin Hu
Reactive N inputs (Nr) may alleviate N-limitation of plant growth and are assumed to help sustain plant responses to the rising atmospheric CO2 (eCO2). However, Nr and eCO2 may elicit a cascade reaction that alters soil chemistry and nutrient availability, shifting the limiting factors of plant growth, particularly in acidic tropical and subtropical croplands with low organic matter and low nutrient cations. Yet, few have so far examined the interactive effects of Nr and eCO2 on the dynamics of soil cation nutrients and soil acidity...
May 17, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29771471/fluorescent-ph-responsive-probes-based-on-water-soluble-bodipy-featuring-long-wavelength-emission
#19
Gilles Ulrich, Alexandra Sutter, Mourad Elhabiri
We describe here the synthesis of water soluble Red-NIR emissive BODIPY derivatives displaying optical (absorption and emission) responses in pH ranges of interest. Substitution effects close to the tertiary aniline or the phenol subunits selected as the proton sensitive sites allowed us to finely tune the pH ranges. Furthermore, introduction of sulfobetaine functions at the boron centre of these pH responsive BODIPYs afforded valuable fluorescent dyes in the Red-NIR region in aqueous media, for which the steric hindrance and electrostatic repulsions prevent their non emissive aggregation...
May 17, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29770519/shell-sheddable-poly-n-2-hydroxypropyl-methacrylamide-polymeric-micelles-for-dual-sensitive-release-of-doxorubicin
#20
Jiajing Zhang, Hao Tang, Yi Shen, Qingsong Yu, Zhihua Gan
Poly(ethylene glycol) (PEG) shell-sheddable micelles are proved to be effective tools for rapid intracellular drug delivery. However, some adverse factors, such as the potential immunogenicity and the accelerated blood clearance, might be accompanied with the traditional PEG sheddable micelles. Here, a poly(N-2-hydroxypropyl methacrylamide) (PHPMA) sheddable block copolymer containing disulfide bonds on the main chain is prepared to form pH- and reduction-dual-responsive micelles. The most optimal synthetic route of the block copolymer is selected from three potential pathways...
May 16, 2018: Macromolecular Rapid Communications
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