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https://www.readbyqxmd.com/read/28106498/performing-concurrent-operations-in-academic-vascular-neurosurgery-does-not-affect-patient-outcomes
#1
Corinna C Zygourakis, Janelle Lee, Julio Barba, Errol Lobo, Michael T Lawton
OBJECTIVE Concurrent surgeries, also known as "running two rooms" or simultaneous/overlapping operations, have recently come under intense scrutiny. The goal of this study was to evaluate the operative time and outcomes of concurrent versus nonconcurrent vascular neurosurgical procedures. METHODS The authors retrospectively reviewed 1219 procedures performed by 1 vascular neurosurgeon from 2012 to 2015 at the University of California, San Francisco. Data were collected on patient age, sex, severity of illness, risk of mortality, American Society of Anesthesiologists (ASA) status, procedure type, admission type, insurance, transfer source, procedure time, presence of resident or fellow in operating room (OR), number of co-surgeons, estimated blood loss (EBL), concurrent vs nonconcurrent case, severe sepsis, acute respiratory failure, postoperative stroke causing neurological deficit, unplanned return to OR, 30-day mortality, and 30-day unplanned readmission...
January 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28105230/dendritic-cell-activated-cytokine-induced-killer-cell-mediated-immunotherapy-is-safe-and-effective-for-cancer-patients-65-years-old
#2
Yanfeng Liu, Haibo Liu, Hausheng Liu, Pengcheng He, Jing Li, Xin Liu, Limei Chen, Mengchang Wang, Jiejing Xi, Huaiyu Wang, Haitao Zhang, Ying Zhu, Wei Zhu, Jing Ning, Caili Guo, Chunhong Sun, Mei Zhang
Individuals >65 years old account for a large proportion of cancer patients, and usually have poor prognoses due to relative weaker physiological function and lower drug tolerance. To characterize the efficacy and safety of dendritic cell (DC)-activated cytokine-induced killer cell (CIK)-mediated treatment, and develop an adoptive immunotherapy for cancer patients >65 years old, a retrospective study was performed in 58 cancer sufferers who received 1-4 cycles of DC-activated CIK (DC-CIK) treatment and evaluated the response (tumor remission rate) and toxicity (side effects to the treatment)...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28105111/effect-of-rocuronium-on-the-bispectral-index-under-anesthesia-and-tracheal-intubation
#3
Hui Yue, Jinyu Han, Ling Liu, Kaiyuan Wang, Jincheng Li
The aim of the present study was to investigate the effect of various doses of rocuronium on bispectral index (BIS) responses to propofol induction and tracheal intubation, as well as the role of the non-depolarization muscle relaxant rocuronium on the depth of sedation. A total of 72 patients (American Society of Anesthesiologists physical status I-II) were anaesthetized with propofol using a target-controlled infusion, and randomly divided into two sedation level groups (n=36). The patients were divided into 2 groups according to the BIS value: A normal sedation group (group 1), with a stable BIS value at 40-60, and a deep sedation group (group 2), with a BIS value <20 or with burst suppression...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28104596/operationalising-ethical-challenges-in-dementia-research-a-systematic-review-of-current-evidence
#4
Emily West, Astrid Stuckelberger, Sophie Pautex, Janneke Staaks, Marjolein Gysels
BACKGROUND: the worldwide number of dementia cases is increasing, and this is a trend that is expected to continue as a growing proportion of the population ages. However, conducting research with persons suffering from dementia can be fraught due to fears surrounding research risks in vulnerable populations. This can make seeking approval for studies difficult. As research directly involving persons with dementia is key for the development of evidence-based best practice, the development of a coherent ethical strategy to perform such research feasibly and effectively is of paramount importance...
January 18, 2017: Age and Ageing
https://www.readbyqxmd.com/read/28104427/novel-cpr-system-that-predicts-return-of-spontaneous-circulation-from-amplitude-spectral-area-before-electric-shock-in-ventricular-fibrillation
#5
Yoshihide Nakagawa, Mari Amino, Sadaki Inokuchi, Satoshi Hayashi, Tsutomu Wakabayashi, Tatsuya Noda
AIM: Amplitude spectral area (AMSA), an index for analysing ventricular fibrillation (VF) waveforms, is thought to predict the return of spontaneous circulation (ROSC) after electric shocks, but its validity is unconfirmed. We developed an equation to predict ROSC, where the change in AMSA (ΔAMSA) is added to AMSA measured immediately before the first shock (AMSA1). We examine the validity of this equation by comparing it with the conventional AMSA1-only equation. METHOD: We retrospectively investigated 285 VF patients given prehospital electric shocks by emergency medical services...
January 16, 2017: Resuscitation
https://www.readbyqxmd.com/read/28103717/baccharis-trimera-inhibits-reactive-oxygen-species-production-through-pkc-and-down-regulation-p47-phox-phosphorylation-of-nadph-oxidase-in-sk-hep-1-cells
#6
Glaucy Rodrigues de Araújo, Ana Carolina Silveira Rabelo, Janaína Serenato Meira, Joamyr Victor Rossoni-Júnior, William de Castro-Borges, Renata Guerra-Sá, Maurício Azevedo Batista, Denise da Silveira-Lemos, Gustavo Henrique Bianco de Souza, Geraldo Célio Brandão, Míriam Martins Chaves, Daniela Caldeira Costa
Baccharis trimera, popularly known as "carqueja", is a native South-American plant possessing a high concentration of polyphenolic compounds and therefore high antioxidant potential. Despite the antioxidant potential described for B. trimera, there are no reports concerning the signaling pathways involved in this process. So, the aim of the present study was to assess the influence of B. trimera on the modulation of PKC signaling pathway and to characterize the effect of the nicotinamide adenine dinucleotide phosphate oxidase enzyme (NOX) on the generation of reactive oxygen species in SK Hep-1 cells...
February 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28103558/effective-multi-query-expansions-collaborative-deep-networks-based-feature-learning-for-robust-landmark-retrieval
#7
Yang Wang, Xuemin Lin, Lin Wu, Wenjie Zhang
Given a query photo issued by a user (q-user), the landmark retrieval is to return a set of photos with their landmarks similar to those of the query, while the existing studies on the landmark retrieval focus on exploiting geometries of landmarks for similarity matches between candidate photos and a query photo. We observe that the same landmarks provided by different users over social media community may convey different geometry information depending on the viewpoints and/or angles, and may subsequently yield very different results...
January 18, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28102529/recovery-from-chemotherapy-induced-white-matter-changes-in-young-breast-cancer-survivors
#8
Thibo Billiet, Louise Emsell, Mathieu Vandenbulcke, Ronald Peeters, Daan Christiaens, Alexander Leemans, Wim Van Hecke, Ann Smeets, Frederic Amant, Stefan Sunaert, Sabine Deprez
In a previous longitudinal diffusion tensor imaging (DTI) study, we observed cerebral white matter (WM) alterations (reduced fractional anisotropy (FA)) related to decreased cognitive performance 3-5 months after chemotherapy-treatment (t2) when compared to baseline (t1) (Deprez et al. in Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology, 30(3), 274-281. doi:10.1200/JCO.2011.36.8571, 2012). The current study investigates the evolution and the nature of these previously observed microstructural changes...
January 19, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28102165/occupational-activity-in-patients-10-years-after-hip-replacement-surgery
#9
Teresa Pop, Ewelina Czenczek-Lewandowska, Bogumił Lewandowski, Justyna Leszczak, Justyna Podgórska-Bednarz, Joanna Baran
BACKGROUND: Advanced hip osteoarthritis requires total joint replacement surgery to improve daily activity, including occupational activity. The purpose of this study was to evaluate employment status among patients 10 years after hip replacement surgery. MATERIAL AND METHODS: A total of 63 patients who underwent total hip replacement surgery at the Department of Orthopedics and Traumatology between 2003 and 2005 were enrolled in the study. At the time of the study (2014), all patients from the study group were of working age...
August 30, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28099198/osteomyelitis-of-the-navicular-bone-a-case-report
#10
Nobuyuki Kumahashi, Suguru Kuwata, Shinji Imade, Yuji Uchio
A 16-year-old boy developed left foot pain of unknown cause that was unresponsive to conservative treatment, associated with fever and difficulty walking. He was admitted to our hospital with osteomyelitis of the accessory and body of the navicular bone. Surgery could not be performed because the patient had been diagnosed with Wiskott-Aldrich syndrome. After antibiotic therapy, laboratory abnormalities and pain had resolved. One year after treatment, the patient had returned to his original level of sports activity...
January 17, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28098526/ancylostoma-ceylanicum-hookworm-in-the-solomon-islands
#11
Richard S Bradbury, Sze Fui Hii, Humpress Harrington, Richard Speare, Rebecca Traub
Although hookworm is highly prevalent in the Solomon Islands, the species involved are unknown. We initiated this study in response to finding Ancylostoma ceylanicum hookworm in a peacekeeper in Australia who had returned from the Solomon Islands. Kato-Katz fecal surveys performed in 2013 and 2014 in 2 village groups in East Malaita, Solomon Islands, identified hookworm-positive samples. These specimens were tested by cytochrome oxidase 1 (cox-1) gene multiplex PCR and sequenced. Of 66 positive specimens, 54 (81...
February 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28098055/nonsurgical-treatment-of-mason-type-ii-radial-head-fractures-in-athletes-a-retrospective-study
#12
M Guzzini, A Vadalà, A Agrò, V Di Sanzo, D Pironi, A Redler, P Serlorenzi, L Proietti, C Civitenga, D Mazza, R M Lanzetti, Andrea Ferretti
OBJECTIVE: The best treatment for moderately displaced radial head fractures (Mason type II) still remains controversial. In cases of isolated fractures, there is no evidence that a fragment displacement of ≥ 2 mm gives poor results in conservatively treated fractures. PATIENTS AND METHODS: We retrospectively reviewed 52 patients (31M, 21F) affected by an isolated Mason type II fracture, treated with a long arm cast for two weeks between 2008 and 2013. All patients had practiced sports before being injured...
September 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28097180/the-role-of-nurses-in-coping-process-of-family-caregivers-of-vegetative-patients-a-qualitative-study
#13
Zahra Imanigoghary, Hamid Peyrovi, Esmat Nouhi, Majid Kazemi
BACKGROUND: Vegetative state (VS) occurs through return of the brain stem after coma state. After hospital discharge, responsibility of caring for VS patients is transferred to their families, which causes a high burden on them. Nurses have an important role in helping the family caregivers to meet their needs and cope with difficulties. To explore the role of nurses during coping process of family caregivers of VS patients. METHODS: This study is a part of a larger qualitative study which was performed in Kerman province, Iran during 2014- 2015...
January 2017: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/28096496/a-reminder-of-extinction-reduces-relapse-in-an-animal-model-of-voluntary-behavior
#14
Javier Nieto, Metin Uengoer, Rodolfo Bernal-Gamboa
One experiment with rats explored whether an extinction-cue prevents the recovery of extinguished lever-pressing responses. Initially, rats were trained to perform one instrumental response (R1) for food in Context A, and a different instrumental response (R2) in Context B. Then, responses were extinguished each in the alternate context (R1 in Context B; R2 in Context A). For one group, extinction of both responses was conducted in the presence of an extinction-cue, whereas in a second group, the extinction-cue only accompanied extinction of R1...
February 2017: Learning & Memory
https://www.readbyqxmd.com/read/28096064/evaluation-of-financial-burdens-following-complications-after-major-surgery-in-france-potential-returns-after-perioperative-goal-directed-therapy
#15
Alain Landais, Morgane Morel, Jacques Goldstein, Jerôme Loriau, Annie Fresnel, Corinne Chevalier, Gilles Rejasse, Pascal Alfonsi, Claude Ecoffey
OBJECTIVE: Perioperative goal directed therapy (PGDT) has been demonstrated to improve postoperative outcomes and reduce the length of hospital stays. The objective of our analysis was to evaluate the cost of complications, derived from French hospital payments, and calculate the potential cost savings and length of hospital stay reductions. METHODS: The billing of 2,388 patients who underwent scheduled high-risk surgery (i.e. major abdominal, gynaecologic, urological, vascular, and orthopaedic interventions) over three years was retrospectively collected from three French hospitals (one public - teaching, one public, and one private hospital)...
January 13, 2017: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/28095901/risk-assessment-tools-to-predict-location-of-discharge-and-need-for-supportive-services-for-medical-patients-after-discharge-from-hospital-a-systematic-review-protocol
#16
Daniel M Kobewka, Daniel McIsaac, Michaël Chassé, Kednapa Thavorn, Sunita Mulpuru, Luke T Lavallée, Shane English, Justin Presseau, Alan J Forster
BACKGROUND: Patients who are discharged from hospital after an acute medical illness often have impaired function that prevents them from returning to their previous place of residence. Assessing each patient's post-discharge needs takes time and resources but is important in order to reduce unplanned readmissions and adverse events post-discharge. METHODS/DESIGN: We will conduct a systematic review to synthesize the evidence on prognostic models and their reported accuracy in predicting the location of discharge after a medical admission to an acute care hospital...
January 17, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28095787/the-effects-of-habitual-functional-training-on-physical-functioning-in-patients-after-hip-fracture-the-protocol-of-the-hipfrac-study
#17
Kristi Elisabeth Heiberg, Vigdis Bruun-Olsen, Astrid Bergland
BACKGROUND: The survivors after hip fracture often report severe pain and loss of physical functioning. The poor outcomes cause negative impact on the person's physical functioning and quality of life and put a financial burden on society. Rehabilitation is important to improve physical functioning after hip fracture. To maintain the continuity in rehabilitation we have an assumption that it is of utmost importance to continue and progress the functional training that already started at the hospital, while the patients are transferred to short-term stays in a nursing home before they are returning to home...
January 17, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28095411/optimal-management-strategies-for-primary-hpv-testing-for-cervical-screening-cost-effectiveness-evaluation-for-the-national-cervical-screening-program-in-australia
#18
Kate T Simms, Michaela Hall, Megan A Smith, Jie-Bin Lew, Suzanne Hughes, Susan Yuill, Ian Hammond, Marion Saville, Karen Canfell
BACKGROUND: Several countries are implementing a transition to HPV testing for cervical screening in response to the introduction of HPV vaccination and evidence indicating that HPV screening is more effective than cytology. In Australia, a 2017 transition from 2-yearly conventional cytology in 18-20 to 69 years to 5-yearly primary HPV screening in 25 to 74 years will involve partial genotyping for HPV 16/18 with direct referral to colposcopy for this higher risk group. The objective of this study was to determine the optimal management of women positive for other high-risk HPV types (not 16/18) ('OHR HPV')...
2017: PloS One
https://www.readbyqxmd.com/read/28095343/patient-tailored-management-of-an-asymptomatic-massive-substernal-goiter-presenting-as-brachiocephalic-vein-occlusion-report-of-a-case-and-review-of-sternotomy-indications
#19
Georgios Sahsamanis, Eleftherios Chouliaras, Konstantinos Katis, Stavros Samaras, Stavros Daliakopoulos, Georgios Dimitrakopoulos
INTRODUCTION: Substernal goiters are characterized by the protrusion of at least 50% of the thyroid mass below the level of the thoracic inlet. Still their definition is controversial. CASE PRESENTATION: The case refers to a 44year old male who presented to our department due to swelling and a feeling of 'heaviness' of his left upper extremity for the past 6 months. CT scan revealed a massive substernal goiter extending to the great vessels. Intraoperatively, a median sternotomy was performed due to the size of the gland and the close adhesion of the isthmus and lower left thyroid lobe to the brachiocephalic vein...
January 4, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28095173/performance-of-a-trigger-tool-for-identifying-adverse-events-in-oncology
#20
Allison Lipitz-Snyderman, David Classen, David Pfister, Aileen Killen, Coral L Atoria, Elizabeth Fortier, Andrew S Epstein, Christopher Anderson, Saul N Weingart
PURPOSE: Although patient safety is a priority in oncology, few tools measure adverse events (AEs) beyond treatment-related toxicities. The study objective was to assemble a set of clinical triggers in the medical record and assess the extent to which triggered events identified AEs. METHODS: We performed a retrospective cohort study to assess the performance of an oncology medical record screening tool at a comprehensive cancer center. The study cohort included 400 patients age 18 years or older diagnosed with breast (n = 128), colorectal (n = 136), or lung cancer (n = 136), observed as in- and outpatients for up to 1 year...
January 17, 2017: Journal of Oncology Practice
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