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sleep apnea and inflammation

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https://www.readbyqxmd.com/read/28076452/angiotensin-1-7-relieved-renal-injury-induced-by-chronic-intermittent-hypoxia-in-rats-by-reducing-inflammation-oxidative-stress-and-fibrosis
#1
W Lu, J Kang, K Hu, S Tang, X Zhou, S Yu, L Xu
We aimed to study the renal injury and hypertension induced by chronic intermittent hypoxia (CIH) and the protective effects mediated by angiotensin 1-7 [Ang(1-7)]. We randomly assigned 32 male Sprague-Dawley rats (body weight 180-200 g) to normoxia control, CIH, Ang(1-7)-treated normoxia, and Ang(1-7)-treated CIH groups. Systolic blood pressure (SBP) was monitored at the start and end of each week. Renal sympathetic nerve activity (RSNA) was recorded. CTGF and TGF-β were detected by immunohistochemistry and western blotting...
January 9, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28040290/obstructive-sleep-and-atrial-fibrillation-pathophysiological-mechanisms-and-therapeutic-implications
#2
REVIEW
Christos A Goudis, Dimitrios G Ketikoglou
Atrial fibrillation (AF) is the commonest arrhythmia in clinical practice and is associated with increased cardiovascular morbidity and mortality. Obstructive sleep apnea (OSA), a common breathing disorder, is an independent risk factor for AF. Several pathophysiological mechanisms, including apnea-induced hypoxia, intrathoracic pressure shifts, sympathovagal imbalance, atrial remodeling, oxidative stress, inflammation and neurohumoral activation have been implicated in the occurrence of AF in OSA patients...
December 22, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27938914/early-effects-of-continuous-positive-airway-pressure-in-a-rodent-model-of-allergic-rhinitis
#3
I Vilaseca, E Lehrer-Coriat, M Torres, F Aguilar, I Almendros, B M Martínez-Vidal, R Farré, J M Montserrat
BACKGROUND: Continuous positive airway pressure (CPAP) is the most commonly used treatment in obstructive sleep apnea. In a previous rat model study, we demonstrated that nasal CPAP induces early rhinitis expressed by nasal neutrophil extravasation. Here we hypothesized that nasal CPAP would worsen nasal inflammation on a previously inflamed mucosa. The objective of this study was to evaluate the early nasal CPAP effects of allergic rhinitis (AR) in a rodent model. METHODS: Twenty Sprague-Dawley rats were sensitized with intraperitoneal ovalbumin (OVA)...
November 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27931299/association-of-allergy-immunology-and-obstructive-sleep-apnea
#4
Charles J Calais, Brian D Robertson, Douglas E Beakes
Obstructive sleep apnea (OSA) is characterized by repetitive upper airway collapse that results in nonrefreshing sleep, excessive daytime sleepiness, and, ultimately, adverse consequences on quality of life, the cardiovascular system, and neurocognitive performance. OSA has traditionally been linked to body habitus (obesity and increased neck circumference), racial demographics, alcohol, tobacco, and sedative use. Numerous other conditions are linked to OSA, which may have clinical relevance. Specifically, asthma and nasal obstructive syndromes, e...
November 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27924067/chronic-intermittent-hypoxia-induces-cardiac-inflammation-and-dysfunction-in-a-rat-obstructive-sleep-apnea-model
#5
Qin Wei, Yeping Bian, Fuchao Yu, Qiang Zhang, Guanghao Zhang, Yang Li, Songsong Song, Xiaomei Ren, Jiayi Tong
Chronic intermittent hypoxia is considered to play an important role in cardiovascular pathogenesis during the development of obstructive sleep apnea (OSA). We used a well-described OSA rat model induced with simultaneous intermittent hypoxia. Male Sprague Dawley rats were individually placed into plexiglass chambers with air pressure and components were electronically controlled. The rats were exposed to intermittent hypoxia 8 hours daily for 5 weeks. The changes of cardiac structure and function were examined by ultrasound...
November 2016: Journal of Biomedical Research
https://www.readbyqxmd.com/read/27896929/impact-of-inflammation-and-oxidative-stress-on-carotid-intima-media-thickness-in-obstructive-sleep-apnea-patients-without-metabolic-syndrome
#6
Ya-Ting Chang, Hsin-Ching Lin, Wen-Neng Chang, Nai-Wen Tsai, Chih-Cheng Huang, Hung-Chen Wang, Chia-Te Kung, Yu-Jih Su, Wei-Che Lin, Ben-Chung Cheng, Chih-Min Su, Ting-Yao Chen, Yi-Fang Chiang, Cheng-Hsien Lu
Obstructive sleep apnea (OSA) increases the risk of cardiovascular diseases, and carotid intima-media thickness (IMT) is a good indicator of the severity of atherosclerotic disease. This study tested the hypothesis that inflammation and oxidative stress determined carotid IMT in patients with OSA. The carotid IMT, mean systolic and diastolic pressure (night and morning) were significantly higher and the level of thiols and high-density lipoprotein were significantly lower in our 121 OSA patients than in 27 controls (P < 0...
November 28, 2016: Journal of Sleep Research
https://www.readbyqxmd.com/read/27888992/il-17-protein-levels-in-both-induced-sputum-and-plasma-are-increased-in-stable-but-not-acute-asthma-individuals-with-obesity
#7
Jian-Hui Chen, Ling Qin, Ying-Ying Shi, Jun-Tao Feng, Yu-Long Zheng, Yu-Feng Wan, Chuan-Qin Xu, Xiao-Mei Yang, Cheng-Ping Hu
BACKGROUND: Obesity worsens asthma control partly through enhanced airway neutrophilia, altered lung mechanics and comorbidities, including obstructive sleep apnea syndrome, gastroesophageal reflux disease and depression. Although controversial, obesity may also cause poorer outcomes in acute asthma. IL-17 is associated with neutrophilic inflammation, steroid resistance and severe asthma, but its importance in the association between asthma and obesity is unknown. OBJECTIVE: To investigate the role of IL-17 in obese asthma in both acute and stable settings...
December 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27886849/prevalence-and-burden-of-comorbidities-in-chronic-obstructive-pulmonary-disease
#8
REVIEW
Alexandru Corlateanu, Serghei Covantev, Alexander G Mathioudakis, Victor Botnaru, Nikolaos Siafakas
The classical definition of Chronic Obstructive Pulmonary Disease (COPD) as a lung condition characterized by irreversible airway obstruction is outdated. The systemic involvement in patients with COPD, as well as the interactions between COPD and its comorbidities, justify the description of chronic systemic inflammatory syndrome. The pathogenesis of COPD is closely linked with aging, as well as with cardiovascular, endocrine, musculoskeletal, renal, and gastrointestinal pathologies, decreasing the quality of life of patients with COPD and, furthermore, complicating the management of the disease...
November 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27862259/the-association-between-gastroesophageal-reflux-disease-gerd-with-sleep-quality-depression-and-anxiety-in-a-cohort-study-of-australian-men
#9
Zhi Xiang On, Janet Grant, Zumin Shi, Anne W Taylor, Gary A Wittert, Phillip J Tully, Amie C Hayley, Sean Martin
BACKGROUND & AIM: Previous clinical studies have demonstrated a relationship between gastro-esophageal reflux disease (GERD) with anxiety and depression; however few population-based studies have controlled for sleep disorders. The current study aimed to assess the relationship between GERD and anxiety, depression, and sleep disorders in a community-based sample of Australian men. METHODS: Participants comprised a sub-set of 1,612 men (mean age: 60.7 years, range: 35 - 80) who participated in the Men Androgen Inflammation Lifestyle Environment and Stress (MAILES) Study during the years 2001-2012, who had complete GERD measures [Gastresophageal Reflux Disease Questionnaire (GerdQ)] and were not taking medications known to impact gastrointestinal function (excluding drugs taken for acid-related disorders)...
November 11, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27843647/cystatin-c-levels-in-middle-aged-patients-with-obstructive-sleep-apnea-syndrome
#10
Kostas Archontogeorgis, Evangelia Nena, Christina Tsigalou, Athanasios Voulgaris, Maria Xanthoudaki, Marios Froudarakis, Paschalis Steiropoulos
Background. Obstructive sleep apnea syndrome (OSAS) is associated with systemic inflammation and increased risk of cardiovascular and chronic kidney disease. Cystatin C (Cyst C) is a novel biomarker of both latent renal damage and cardiovascular disease. Aim of the study was to measure serum levels of Cyst C, as well as IL-8 and CRP, in otherwise healthy OSAS patients. Methods. 84 individuals examined with polysomnography for OSAS symptoms without known comorbidities were prospectively recruited. Results. According to apnea hypopnea index (AHI) subjects were divided in two groups: OSAS group (AHI > 5/hour, n = 64) and controls (AHI < 5/hour, n = 20), which were age- and BMI-matched...
2016: Pulmonary Medicine
https://www.readbyqxmd.com/read/27837378/nasal-nitric-oxide-improved-by-continuous-positive-airway-pressure-therapy-for-upper-airway-inflammation-in-obstructive-sleep-apnea
#11
Satoshi Hamada, Shuji Tatsumi, Yoshiki Kobayashi, Hirotaka Yasuba
PURPOSE: In this report, we examined the association between obstructive sleep apnea (OSA) and upper and lower airway inflammation based on nitric oxide (NO) measurements. METHODS: Study subjects included 51 consecutive participants. Sleep-disordered breathing was evaluated by a type 3 portable monitor and quantified by respiratory disturbance index (RDI). Airway inflammation was noninvasively analyzed by the measurement of nasally and orally exhaled NO; nasal value was presented as nasally exhaled NO minus orally exhaled NO...
November 12, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27800512/chronic-intermittent-hypoxia-and-obstructive-sleep-apnea-an-experimental-and-clinical-approach
#12
REVIEW
Emilia Sforza, Fréderic Roche
Obstructive sleep apnea (OSA) is a prevalent sleep disorder considered as an independent risk factor for cardiovascular consequences, such as systemic arterial hypertension, ischemic heart disease, cardiac arrhythmias, metabolic disorders, and cognitive dysfunction. The pathogenesis of OSA-related consequence is assumed to be chronic intermittent hypoxia (IH) inducing alterations at the molecular level, oxidative stress, persistent systemic inflammation, oxygen sensor activation, and increase of sympathetic activity...
2016: Hypoxia
https://www.readbyqxmd.com/read/27752937/fractalkine-in-obstructive-sleep-apnea-patients
#13
Gulgun Cetintas Afsar, Ozlem Oruc, Sema Sarac, Özgür Bilgin Topçuoğlu, Cuneyt Salturk, Fatma Merve Tepetam, Ismet Bulut
BACKGROUND: Obstructive sleep apnea (OSA) is the most common sleep disorder affecting 2-4 % of the adult population. In addition to several potential mechanisms, inflammation is one of the suggested etiological factors in OSA. Fractalkine/CX3CL1 which is detected in activated or stressed endothelium, smooth muscle cells, skeletal muscle cells, macrophages, neurons, and hepatocytes is an inflammatory marker and attracts attention of sleep specialists in OSA pathogenesis. In this study, we had two goals...
October 17, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27748237/objective-but-not-subjective-sleepiness-is-associated-with-inflammation-in-sleep-apnea
#14
Yun Li, Alexandros N Vgontzas, Julio Fernandez-Mendoza, Ilia Kritikou, Maria Basta, Slobodanka Pejovic, Jordan Gaines, Edward O Bixler
STUDY OBJECTIVES: Objective and subjective measures of excessive daytime sleepiness (EDS) are only weakly associated. No study, however, has examined whether these two measures of EDS differ in terms of underlying mechanisms and prognostic value. Pro-inflammatory cytokines, i.e., interleukin-6 (IL-6) appear to promote sleepiness/fatigue, while the stress hormone cortisol promotes vigilance. We hypothesized that objective sleepiness is associated with increased levels of IL-6 and decreased levels of cortisol...
October 10, 2016: Sleep
https://www.readbyqxmd.com/read/27748200/statins-may-prevent-atherosclerotic-disease-in-osa-patients-without-co-morbidities
#15
Domenico Maurizio Toraldo, Michele De Benedetto, Luana Conte, Francesco De Nuccio
Obstructive sleep apnoea (OSA) is characterized by repetitive interruptions of breathing, causing Chronic Intermittent Hypoxia (CIH) that can be involved in the development and progression of cardiovascular diseases. There is evidence showing a close relationship between OSA and atherosclerosis, even in patients who do not show co-morbidities such as hypertension, diabetes, high levels of lowdensity lipoprotein cholesterol (LDL-C), cigarette smoking and obesity, which can activate the endothelium. This endothelium activation due to CIH and specific to OSA seems to be dependent on a different pathway...
2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27741107/inflammatory-cytokines-in-pediatric-obstructive-sleep-apnea
#16
Yu-Shu Huang, Christian Guilleminault, Fang-Ming Hwang, Chuan Cheng, Cheng-Hui Lin, Hsueh-Yu Li, Li-Ang Lee
Pediatric obstructive sleep apnea (OSA) is associated with chronic systemic inflammation and with cognitive impairments. This study aimed to investigate the status of proinflammatory cytokines, particularly interleukin 17 (IL-17) and interleukin 23 (IL-23) and cognition in pediatric OSA.Controls and OSA children participated in the study. Exclusion criteria were adenotonsillectomy, heart, neurological and severe psychiatric diseases, craniofacial syndromes, and obesity. Polysomnogram was followed by serum testing for inflammatory markers and neurocognitive tests such as continuous performance task (CPT) and Wisconsin card sorting test, questionnaires, analyses of plasma high-sensitivity C-reactive protein (HS-CRP), tumor necrosis factor alpha (TNF-α), interleukin 1 (IL-1), interleukin 6 (IL-6), IL-17, and IL-23...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27738828/intermittent-hypoxia-contributes-to-the-lung-damage-by-increased-oxidative-stress-inflammation-and-disbalance-in-protease-antiprotease-system
#17
I Tuleta, F Stöckigt, U R Juergens, C Pizarro, J W Schrickel, G Kristiansen, G Nickenig, D Skowasch
INTRODUCTION: Intermittent hypoxia as a surrogate of obstructive sleep apnea is associated with different cardiovascular complications. However, the effects of intermittent hypoxia on the lung tissue are less known. Therefore, the aim of our present study was to investigate if intermittent hypoxia may influence oxidative stress, inflammation, and protease/antiprotease system in the lung. Additionally, potential protective properties of anti-inflammatory and anti-oxidative drugs have been evaluated...
October 13, 2016: Lung
https://www.readbyqxmd.com/read/27729114/asthma-outcomes-after-adenotonsillectomy-a-systematic-review
#18
Nikita Kohli, Dana DeCarlo, Nira A Goldstein, Joshua Silverman
OUTCOME OBJECTIVE: For over fifty years, otolaryngologists, allergists, and immunologists have debated the effect of adenoidectomy or adenotonsillectomy on asthma outcomes in children. Although some have suggested that adenotonsillectomy may contribute to the subsequent development of asthma in children, others have argued that a common mechanism may cause both upper and lower airway disease, and that children who have symptoms severe enough to warrant adenotonsillectomy are also at increased risk of asthma and atopic disease...
November 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27707440/vitamin-d-improves-selected-metabolic-parameters-but-not-neuropsychological-or-quality-of-life-indices-in-osas-a-pilot-study
#19
Conor P Kerley, Katrina Hutchinson, Jessica Bramham, Aisling McGowan, John Faul, Liam Cormican
STUDY OBJECTIVES: Our group and others have reported a high rate of vitamin D deficiency in obstructive sleep apnoea syndrome (OSAS), where vitamin D levels (25(OH)D) correlate negatively with OSAS severity and some of its associated metabolic alterations. Data regarding vitamin D supplementation in OSAS are lacking. We wanted to evaluate the effect of vitamin D3 supplementation on OSAS symptoms and metabolic parameters. METHODS: We conducted a pilot, double-blind, randomized, placebo-controlled trial of daily supplementation with 4,000 IU vitamin D3 (D3) or placebo (PL)...
September 29, 2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27693594/obstructive-sleep-apnea-and-cardiac-arrhythmogenesis-mechanistic-insights
#20
REVIEW
Anna M May, David R Van Wagoner, Reena Mehra
A surge of data has reproducibly identified strong associations of obstructive sleep apnea (OSA) with cardiac arrhythmias. As an extension of epidemiologic and clinic-based findings, experimental investigations have made strides in advancing our understanding of the putative OSA and cardiac arrhythmogenesis mechanistic underpinnings. While most studies have focused on the links between OSA and atrial fibrillation (AF), relationships with ventricular arrhythmias have also been characterized. Key findings implicate OSA-related autonomic nervous system fluctuations typified by enhanced parasympathetic activation during and sympathetic surges subsequent to respiratory events which contribute to augmented arrhythmic propensity...
September 29, 2016: Chest
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