Read by QxMD icon Read


Wail Alkashkari, Amani Alsubei, Ziyad M Hijazi
PURPOSE OF REVIEW: The past couple of decades have brought tremendous advances to the field of pediatric and adult congenital heart disease (CHD). Percutaneous valve interventions are now a cornerstone of not just the congenital cardiologist treating patients with congenital heart disease, but also-and numerically more importantly-for adult interventional cardiologists treating patients with acquired heart valve disease. Transcatheter pulmonary valve replacement (tPVR) is one of the most exciting recent developments in the treatment of CHD and has evolved to become an attractive alternative to surgery in patients with right ventricular outflow tract (RVOT) dysfunction...
March 15, 2018: Current Cardiology Reports
Mario Lopez-Moya, Pedro Melgar-Lesmes, Kumaran Kolandaivelu, Jose Maria de la Torre Hernandez, Elazer R Edelman, Mercedes Balcells
Porcine glutaraldehyde-fixed pericardium is widely used to replace human heart valves. Despite the stabilizing effects of glutaraldehyde fixation, the lack of endothelialization and the occurrence of immune reactions contribute to calcification and structural valve deterioration, which is particularly significant in young patients where valve longevity is crucial. This report shows an optimization system to enhance endothelialization of fixed pericardium to mimic the biological function of a native heart valve...
March 14, 2018: Biomacromolecules
Michel Carrier, Denis Bouchard
No abstract text is available yet for this article.
February 17, 2018: Journal of Thoracic and Cardiovascular Surgery
Qingling Zhou, Fei Teng, Yongshan Zhang, Qiang Sun, Guowei Meng
OBJECTIVES: We assessed the transventricular placement of porcine small intestinal submucosa (SIS) stent valves in a juvenile sheep model at the 3-month follow-up evaluation. METHODS: We constructed a pulmonary stent valve by suturing a porcine SIS bicuspid valve into a bell-shaped 'Z' nitinol stent and implanted 7 SIS stent valves transventricularly in the pulmonary position in 7 sheep. The function of the stent valves was assessed using a pulsatile flow simulation system in vitro...
March 7, 2018: Interactive Cardiovascular and Thoracic Surgery
Mhairi Katrina Doris, Marc Richard Dweck
No abstract text is available yet for this article.
March 1, 2018: Heart: Official Journal of the British Cardiac Society
Nikolaos Bonaros, Cenk Özpeker, Markus Kofler, Julia Dumfarth, Johannes Holfeld, Thomas Schachner, Ludwig Müller, Michael Grimm
Bioprosthetic aortic valves have been used with increasing frequency over the past two decades, often in relatively young patients who may eventually require aortic valve re-operations due to degeneration of the bioprosthesis. Growing experience with minimally invasive aortic valve replacement has prompted surgeons to use minimally invasive approaches also with redo operations for replacement of the aortic valve.  This tutorial describes the operative steps for a minimally invasive redo replacement of the aortic valve through an upper ministernotomy...
January 30, 2018: Multimedia Manual of Cardiothoracic Surgery: MMCTS
Gabriel S Aldea, Danny Dvir
No abstract text is available yet for this article.
February 1, 2018: Journal of Thoracic and Cardiovascular Surgery
Silje Ekroll Jahren, Paul Philipp Heinisch, David Hasler, Bernhard Michael Winkler, Stefan Stortecky, Thomas Pilgrim, Martina Correa Londono, Thierry Carrel, Hendrik von Tengg-Kobligk, Dominik Obrist
OBJECTIVES: Bioprosthetic valve thrombosis has been considered uncommon, but recent studies have shown that it is more frequent than previously thought. Insufficient washout of the aortic sinus is believed to be a risk factor for bioprosthetic valve thrombosis. The objective of this in vitro experiment was to investigate the impact of aortic root morphology on blood flow in the aortic sinus and to relate these results to in vivo data obtained in patients with a transcatheter aortic valve implant...
February 21, 2018: Interactive Cardiovascular and Thoracic Surgery
Jeremy W Vandiver, K Diane Beavers
Anticoagulant therapy and antiplatelet therapy are used regularly for prevention of arterial and venous thrombosis, and combinations of the two drug classes are seen with relative frequency in clinical practice. While co-prescribing is as high as 39-55% in some real-world cohort studies, the number of patients that meet criteria for combination therapy based on the overall body of evidence is likely much lower. This may not always be realized by prescribers, and many patients may be continued on long term combination therapies that provide little additional benefit, and carry significant risk for harm...
February 24, 2018: Journal of Thrombosis and Thrombolysis
Shamir R Mehta, Kevin R Bainey, Warren J Cantor, Marie Lordkipanidzé, Guillaume Marquis-Gravel, Simon D Robinson, Matthew Sibbald, Derek Y So, Graham C Wong, Joseph G Abunassar, Margaret L Ackman, Alan D Bell, Raymond Cartier, James D Douketis, Patrick R Lawler, Michael S McMurtry, Jacob A Udell, Sean van Diepen, Subodh Verma, G B John Mancini, John A Cairns, Jean-François Tanguay
Antiplatelet therapy (APT) has become an important tool in the treatment and prevention of atherosclerotic events, particularly those associated with coronary artery disease. A large evidence base has evolved regarding the relationship between APT prescription in various clinical contexts and risk/benefit relationships. The Guidelines Committee of the Canadian Cardiovascular Society and Canadian Association of Interventional Cardiology publishes regular updates of its recommendations, taking into consideration the most recent clinical evidence...
March 2018: Canadian Journal of Cardiology
Thoralf M Sundt
No abstract text is available yet for this article.
February 13, 2018: Annals of Thoracic Surgery
Nana Toyoda, Shinobu Itagaki, Henry Tannous, Natalia N Egorova, Joanna Chikwe
BACKGROUND: Consensus guidelines for prosthesis selection in infective endocarditis recommend bioprosthetic or mechanical valve replacement based on life expectancy and comorbidity. However, contemporary outcome data are limited to institution series. METHODS: The outcomes of 3,447 patients identified from mandatory discharge databases in California and New York states who had either primary isolated mitral (n=1603) or aortic (n=1,844) valve replacement for active endocarditis between 1998 and 2010, were compared according to whether they received bioprosthetic (n=1,673, 48...
February 13, 2018: Annals of Thoracic Surgery
Alexander Lauten, Hans R Figulla, Axel Unbehaun, Neil Fam, Joachim Schofer, Torsten Doenst, Joerg Hausleiter, Marcus Franz, Christian Jung, Henryk Dreger, David Leistner, Brunilda Alushi, Anja Stundl, Ulf Landmesser, Volkmar Falk, Karl Stangl, Michael Laule
BACKGROUND: Transcatheter caval valve implantation is under evaluation as a treatment option for inoperable patients with severe tricuspid regurgitation (TR). The procedure involves the catheter-based implantation of bioprosthetic valves in the inferior vena cava and superior vena cava to treat symptoms associated with TR. This study is the first to evaluate the feasibility, safety, and efficacy of this interventional concept. METHODS AND RESULTS: Twenty-five patients (mean age, 73...
February 2018: Circulation. Cardiovascular Interventions
Thierry Bourguignon, Fabien Espitalier, Clémence Pantaleon, Emmanuelle Vermes, Jean Marc El-Arid, Claudia Loardi, Elias Karam, Pascal Candolfi, Fabrice Ivanes, Michel Aupart
OBJECTIVES: Mitral valve replacement using a bioprosthesis remains controversial in young patients because data on long-term outcomes are missing. This study evaluated the long-term results of the PERIMOUNT pericardial mitral bioprosthesis in patients aged 65 years or younger. METHODS: From 1984 to 2010, 148 Carpentier-Edwards PERIMOUNT mitral bioprostheses were implanted in 148 patients aged 65 years or younger. Baseline clinical, perioperative and follow-up data were recorded prospectively...
February 12, 2018: European Journal of Cardio-thoracic Surgery
S S Kothari, Siddharthan Deepti, Nitish Rai
A 31-year-old man with a mitral bioprosthetic valve presented with recent worsening of exertional dyspnoea 7 years after the mitral valve replacement. Evaluation revealed an increased gradient across the thickened mitral bioprosthetic valve leaflets. Marked eosinophilia was present and was considered as a putative cause for bioprosthetic valve thrombosis. The treatment with systemic corticosteroids and oral anticoagulation led to complete resolution of symptoms with significant decrease in mitral bioprosthetic valve gradient and leaflet thinning...
February 8, 2018: BMJ Case Reports
Nicholas S Clarke, Howaida El-Said, John J Lamberti, Raghav A Murthy
Percutaneous therapies for congenital heart disease have been evolving rapidly despite limited investment from industry. The Melody transcatheter pulmonary valve (Medtronic, Inc, Minneapolis, MN USA) replacement therapy represents an important advancement in this arena. It has been approved in the United States for use in the pulmonary position, on a Humanitarian Device Exemption status. Off-label use of the Melody transcatheter pulmonary valve has extended to the mitral, pulmonary, and aortic valves, especially in previously implanted valves with prosthetic valve degeneration...
January 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
Clauden Louis, Michael F Swartz, Bartholomew V Simon, Jill M Cholette, Nader Atallah-Yunes, Hongyue Wang, Francisco Gensini, George M Alfieris
OBJECTIVE: Repair of truncus arteriosus often requires early right ventricular outflow tract (RVOT) re-operation. Using a modified repair the branch pulmonary arteries are left in-situ, which may avoid earlier RVOT reoperation. We hypothesized that our modified repair for Type I and II truncus arteriosus would extend the time to RVOT re-operation. METHODS: Infants with truncus arteriosus were divided into two groups: A) Traditional technique where the branch pulmonary arteries are excised from the truncal root, or B) Modified repair where the branch pulmonary arteries are left in-situ and septated from the truncal root...
February 8, 2018: Seminars in Thoracic and Cardiovascular Surgery
Alfonso Campanile, Guido Tavazzi, Francesco Caprioglio, Fausto Rigo
BACKGROUND: Infective endocarditis (IE) is still a condition with high mortality and morbidity, especially in the elderly, and in patients with prosthetic valves. The concept of "time-to-therapy" plays a key role for the prompt management of IE and related complications, and the currently available multimodality imaging may play a key role in this setting. Myocardial ischemia due to extrinsic coronary compression from an aortic abscess is an extremely rare condition where the optimal therapeutic strategy has not been defined yet...
February 9, 2018: BMC Cardiovascular Disorders
Malenka M Bissell, Margaret Loudon, Aaron T Hess, Victoria Stoll, Elizabeth Orchard, Stefan Neubauer, Saul G Myerson
BACKGROUND: Abnormal aortic flow patterns in bicuspid aortic valve disease (BAV) may be partly responsible for the associated aortic dilation. Aortic valve replacement (AVR) may normalize flow patterns and potentially slow the concomitant aortic dilation. We therefore sought to examine differences in flow patterns post AVR. METHODS: Ninety participants underwent 4D flow cardiovascular magnetic resonance: 30 BAV patients with prior AVR (11 mechanical, 10 bioprosthetic, 9 Ross procedure), 30 BAV patients with a native aortic valve and 30 healthy subjects...
February 8, 2018: Journal of Cardiovascular Magnetic Resonance
Norihiko Kamioka, Frank Corrigan, Jose Miguel Iturbe, Hope Caughron, Stamatios Lerakis, Vinod Thourani, Peter Block, Robert Guyton, Vasilis Babaliaros
No abstract text is available yet for this article.
February 12, 2018: JACC. Cardiovascular Interventions
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"