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https://www.readbyqxmd.com/read/28422037/ureteral-meatotomy-as-an-option-in-the-management-of-primary-obstructive-megaureter-in-neonates-and-infants
#1
Priscila Cardoso Braz, Fernanda Ghilardi Leão, Jovelino Quintino de Souza Leão, Luciano Silveira Onofre, Giselle Machado Campos de Oliveira, José Carnevale, Carlos Miguélez Lago
Differentiating between the cases of megaureter that require surgery and the ones in whom treatment can be delayed is challenging. A large number of surgical techniques for the treatment of POM been proposed aiming mainly to reduce renal damage by relieving the affected ureter. Resection of the affected ureteral segment followed by vesicoureteral reimplantation either with or without reduction ureteroplasty is the classic treatment, however posing a high rate of complications when performed in patients aged less than one year...
April 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28416004/clinical-study-of-children-with-takayasu-arteritis-a-retrospective-study-from-a-single-center-in-china
#2
Ye Feng, Xuemei Tang, Mingyue Liu, Juan Zhou, Xiaodong Zhao, Qiu Li
BACKGROUND: Delayed diagnosis of childhood Takayasu arteritis (TA) is common due to its atypical symptoms. The objective of the present study was to summarize the clinical features of childhood TA to raise awareness and improve management. METHODS: Eleven children diagnosed with TA at our hospital were enrolled. Clinical information, diagnosis, treatment, and outcome were then examined retrospectively. The Pediatric Vasculitis Activity Score (PVAS) and the Indian Takayasu Clinical Activity Score (ITAS2010) were used to assess disease activity...
April 17, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28413308/congenital-pouch-colon-with-rectal-atresia-revisited
#3
Praveen Mathur, Rahul Gupta, Pradeep Kumar Gupta
We are adding two cases of congenital pouch colon with rectal atresia (RA) to the already published five cases. The presentation of RA is often delayed owing to the presence of normal anus, however, clinical evaluation, plain abdominal radiograph, and urine examination for meconuria, may help in detecting this rare association early.
April 2017: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/28411099/robot-assisted-transplanted-ureteral-stricture-management
#4
H M Abdul-Muhsin, S B McAdams, R N Nuñez, N N Katariya, E P Castle
OBJECTIVE: To assess the feasibility of robot assisted transplanted ureteral reimplantation as a minimally invasive alternative to open surgery. MATERIAL AND METHODS: Between August 2015 and March 2016, five patients presented with transplanted ureteral strictures after failure of previous endoscopic management. All patients underwent robot assisted ureteral reimplantation. Patients' demographics, perioperative outcomes and complications are reported. RESULTS: All patients presented with deterioration of kidney function with or without recurrent urinary tract infection...
April 11, 2017: Urology
https://www.readbyqxmd.com/read/28394433/outcomes-associated-with-reducing-the-urine-alkalinization-threshold-in-patients-receiving-high-dose-methotrexate
#5
Sarah A Drost, Jason R Wentzell, Pierre Giguere, Darcy L McLurg, Mitchell Sabloff, Salmaan Kanji, Tiffany T Nguyen
STUDY OBJECTIVES: Urine alkalinization increases methotrexate solubility and reduces the risk of nephrotoxicity. The objectives of this study were to determine whether a reduction in the urine pH threshold from 8 to 7 in patients receiving high-dose methotrexate (HDMTX) results in a shorter length of hospital stay, delayed methotrexate clearance, or higher rates of nephrotoxicity; and to determine whether specific factors were associated with prolonged methotrexate clearance. DESIGN: Retrospective cohort study...
April 10, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28391612/distress-vocalization-delay-in-the-neonate-lamb-as-a-neurobehavioral-assessment-tool
#6
Christine L Morton, Geoffrey Hinch, Alison Small
Acoustic features of infant distress vocalizations including latency and rate of emission are used as indices of neurological deficit and integrity in human and rodent neonates. This paper investigates the relationship between temporal characteristics of distress calls, elicited by an isolation stimulus, and indicators of neurobehavioral development over 12 hr postpartum in the neonate lamb. Delayed vocalization initiation was found to be associated with poor locomotor and orientation behavior reflecting the capacity of the lamb to reunite with and follow its dam, and a lowered rate of signal emission following commencement of vocalization...
April 9, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28389437/paediatric-hypoglycaemia-are-we-investigating-appropriately-and-adequately
#7
Louise Ramsden, Katherine Wright, Anuja Natarajan
INTRODUCTION: Paediatric hypoglycaemia is a relatively common medical emergency. To allow identification of the underlying cause, investigations need to be performed urgently prior to treatment being given. Careful consideration is needed to ensure correct patient selection, as inadequate investigations have further cost and patient safety implications. METHODS: 49 cases of proven or suspected hypoglycaemia (glucose ≤2.6 mmol/L) were identified via the laboratory...
April 6, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28377344/-clinical-and-pathological-features-in-iga-nephropathy-with-igg-deposition-in-the-glomerular-mesangial-area
#8
Xiao-Meng Xu, Shuang-Shuang Zhu, Xiao-Hong Wang, Xiao-Fei Shao, Bin Li, Ying Zhang, Qin Liu, Jia-Min Li, Hong-Lei Wang, Yong-Qiang Li, He-Qun Zou
OBJECTIVE: To investigate the relationship between the clinical and pathological findings in IgA nephropathy with or without IgG deposition in the glomerular mesangial area. METHODS: The data were collected from 122 patients with a diagnosis of IgA nephropathy by renal biopsy in the Third Affiliated Hospital of Southern Medical University between November, 2009 and February, 2016. All the samples were examined by light microscopy, immunofluorescence and electron microscopy...
March 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28376912/head-to-head-comparison-of-aggressive-conventional-therapy-and-three-biological-treatments-and-comparison-of-two-de-escalation-strategies-in-patients-who-respond-to-treatment-study-protocol-for-a-multicenter-randomized-open-label-blinded-assessor-phase-4-study
#9
Daniel Glinatsi, Marte S Heiberg, Anna Rudin, Dan Nordström, Espen A Haavardsholm, Bjorn Gudbjornsson, Mikkel Østergaard, Till Uhlig, Gerdur Grondal, Kim Hørslev-Petersen, Ronald van Vollenhoven, Merete L Hetland
BACKGROUND: New targeted therapies and improved treatment strategies have dramatically improved the outcomes of patients with rheumatoid arthritis (RA). However, it is unknown whether different early aggressive interventions can induce stable remission or a low-active disease state that can be maintained with conventional synthetic disease-modifying antirheumatic drug (csDMARD) therapy, and whether they differ in efficacy and safety. The Nordic Rheumatic Diseases Strategy Trials And Registries (NORD-STAR) study will assess and compare (1) the proportion of patients who achieve remission in a head-to-head comparison between csDMARD plus glucocorticoid therapy and three different biological DMARD (bDMARD) therapies with different modes of action and (2) two de-escalation strategies in patients who respond to first-line therapy...
April 4, 2017: Trials
https://www.readbyqxmd.com/read/28374267/risk-factors-for-and-outcomes-of-multidrug-resistant-escherichia-coli-infections-in-children
#10
Adaora S Uzodi, Christine M Lohse, Ritu Banerjee
INTRODUCTION: The recent increase in multidrug-resistant (MDR) Escherichia coli infections is not well described in children. We determined the risk factors and outcomes of extraintestinal E. coli infections in children in our region. METHODS: We conducted a retrospective cohort study of children ≤18 years in Olmsted County, MN, USA, between January 1, 2012 and December 31, 2012. MDR isolates were defined as resistant to ≥3 antibiotic classes. RESULTS: A total of 368 children each contributed 1 isolate...
April 3, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/28374127/surgical-management-of-solitary-nerve-sheath-tumors-originating-around-the-epiconus-or-conus-medullaris-a-retrospective-case-analysis-based-on-neurological-function
#11
Kentaro Naito, Toru Yamagata, Atsufumi Nagahama, Shinichi Kawahara, Kenji Ohata, Toshihiro Takami
The objective of this retrospective case analysis was to evaluate the surgical impact on neurological functional recovery in cases of solitary spinal nerve sheath tumors (NSTs) originating around the epiconus, conus medullaris, or cauda equina and not associated with neurofibromatosis. This 10-year surgical study included 30 cases of spinal NSTs originating around the spine level of T12-L1 (epiconus-to-conus medullaris: Epi-CM group), and 15 cases of spinal NSTs originating below the spine level of L2 (cauda equina: CE group)...
April 3, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28372954/stability-of-serum-plasma-and-urine-osmolality-in-different-storage-conditions-relevance-of-temperature-and-centrifugation
#12
Macià Sureda-Vives, Daniel Morell-Garcia, Ana Rubio-Alaejos, Laura Valiña, Juan Robles, Josep Miquel Bauça
BACKGROUND: Osmolality reflects the concentration of all dissolved particles in a body fluid, and its measurement is routinely performed in clinical laboratories for the differential diagnosis of disorders related with the hydrolytic balance regulation, the renal function and in small-molecule poisonings. The aim of the study was to assess the stability of serum, plasma and urine osmolality through time and under different common storage conditions, including delayed centrifugation. METHODS: Blood and urine samples were collected, and classified into different groups according to several preanalytical variables: serum or plasma lithium-heparin tubes; spun or unspun; stored at room temperature (RT), at 4°C or frozen at -21°C...
March 31, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28356414/prospective-evaluation-of-light-scatter-technology-paired-with-maldi-tof-mass-spectrometry-for-rapid-diagnosis-of-urinary-tract-infections
#13
Sandra Montgomery, Kiana Roman, Lan Ngyuen, Ana Maria Cardenas, James Knox, Andrew P Tomaras, Erin H Graf
Urinary tract infections are one of the most common reasons for healthcare visits. Diagnosis and optimal treatment often requires a urine culture, which takes an average of 1.5-2 days from urine collection to results, delaying optimal therapy. Faster, but accurate alternatives are needed. Light scatter technology has been proposed for several years as a rapid screening tool, whereby negative specimens are excluded from culture. A commercially available light scatter device, BacterioScan 216Dx (BacterioScan Inc...
March 29, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28355138/ultrasound-to-detect-pressure-related-deep-tissue-injuries-in-adults-admitted-via-the-emergency-department-a-prospective-descriptive-pilot-study
#14
Jonathan Scheiner, Karen Farid, Mark Raden, Seleshi Demisse
Stage 4 pressure ulcers (PUs) start with tissue death at the level of the bone, also known as deep tissue injury (DTI). Studies have shown the appearance of DTI on the skin is delayed for several days after the original pressure-related injury to the deep soft tissues. Studies also suggest DTI can be seen using ultrasound (US) technology. A prospective, descriptive, correlational pilot study was conducted to evaluate the use of US technology to detect DTI in the soft tissues that are not visible on the skin upon hospital admission...
March 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28342973/effects-of-a-sustained-release-formulation-of-1-25-dihydroxyvitamin-d3-glycosides-for-milk-fever-prevention-on-serum-1-25-dihydroxyvitamin-d3-calcium-and-phosphorus-in-dairy-cows
#15
Heinrich Bachmann, Michael Lanz, Susanne Kehrle, Wolfgang Bittner, Annick Toggenburger, Georg A Mathis, Walter Rambeck
Milk fever (MF) is a metabolic disease in dairy cows around parturition. The clinical lead sign is muscular paresis leading in severe cases to paralysis of the affected animal. Multiparturient animals of high performing dairy breeds are most likely to be affected and have a high probability of recurrence. An acute drop in blood calcium levels causes the disease when the demand for calcium at the onset of lactation exceeds the ability to replete blood calcium levels through mobilization from bone and intestinal uptake...
March 23, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28334777/clinicians-interpretations-of-point-of-care-urine-culture-versus-laboratory-culture-results-analysis-from-the-four-country-poetic-trial-of-diagnosis-of-uncomplicated-urinary-tract-infection-in-primary-care
#16
Saskia Hullegie, Mandy Wootton, Theo J M Verheij, Emma Thomas-Jones, Janine Bates, Kerenza Hood, Micaela Gal, Nick A Francis, Paul Little, Michael Moore, Carl Llor, Timothy Pickles, David Gillespie, Nigel Kirby, Curt Brugman, Christopher C Butler
Background.: Urine culture at the point of care minimises delay between obtaining the sample and agar inoculation in a microbiology laboratory, and quantification and sensitivity results can be available more rapidly in primary care. Objective.: To identify the degree to which clinicians' interpretations of a point-of-care-test (POCT) urine culture (Flexicult™ SSI-Urinary Kit) agrees with laboratory culture in women presenting to primary care with symptoms of uncomplicated urinary tract infections (UTI)...
March 1, 2017: Family Practice
https://www.readbyqxmd.com/read/28324240/neurocognitive-profiles-in-msud-school-age-patients
#17
Juliette Bouchereau, Julie Leduc-Leballeur, Samia Pichard, Apolline Imbard, Jean-François Benoist, Marie-Thérèse Abi Warde, Jean-Baptiste Arnoux, Valérie Barbier, Anaïs Brassier, Pierre Broué, Aline Cano, Brigitte Chabrol, Gilles Damon, Claire Gay, Isabelle Guillain, Florence Habarou, Delphine Lamireau, Chris Ottolenghi, Laetitia Paermentier, Frédérique Sabourdy, Guy Touati, Hélène Ogier de Baulny, Pascale de Lonlay, Manuel Schiff
Maple syrup urine disease (MSUD), an inborn error of amino acids catabolism is characterized by accumulation of branched chain amino acids (BCAAs) leucine, isoleucine, valine and their corresponding alpha-ketoacids. Impact on the cognitive development has been reported historically, with developmental delays of varying degree. Currently, earlier diagnosis and improved management allow a better neurodevelopment, without requirement of special education. However, specific impairments can be observed, and so far, results of detailed neurocognitive assessments are not available...
March 21, 2017: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/28323886/contribution-of-urinary-tract-infection-to-the-burden-of-febrile-illnesses-in-young-children-in-rural-kenya
#18
Wechuli Geoffrey Masika, Wendy Prudhomme O'Meara, Thomas L Holland, Janice Armstrong
INTRODUCTION: The clinical features of UTI in young children may not localize to the urinary tract and closely resemble other febrile illnesses. In malaria endemic areas, a child presenting with fever is often treated presumptively for malaria without investigation for UTI. Delayed or inadequate treatment of UTI increases the risk of bacteremia and renal scarring in young children and subsequently complications as hypertension and end stage renal disease in adulthood. METHODS: A cross-sectional study was carried out in a hospital in western Kenya...
2017: PloS One
https://www.readbyqxmd.com/read/28298535/resistant-starch-but-not-enzymatically-modified-waxy-maize-delays-development-of-diabetes-in-zucker-diabetic-fatty-rats
#19
Mette Skou Hedemann, Kjeld Hermansen, Sven Pedersen, Knud Erik Bach Knudsen
Background: The incidence of type 2 diabetes (T2D) is increasing worldwide, and nutritional management of circulating glucose may be a strategic tool in the prevention of T2D.Objective: We studied whether enzymatically modified waxy maize with an increased degree of branching delayed the onset of diabetes in male Zucker diabetic fatty (ZDF) rats.Methods: Forty-eight male ZDF rats, aged 5 wk, were divided into 4 groups and fed experimental diets for 9 wk that contained 52.95% starch: gelatinized corn starch (S), glucidex (GLU), resistant starch (RS), or enzymatically modified starch (EMS)...
March 15, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28292756/trajectories-of-urinary-incontinence-in-childhood-and-bladder-and-bowel-symptoms-in-adolescence-prospective-cohort-study
#20
Jon Heron, Mariusz T Grzeda, Alexander von Gontard, Anne Wright, Carol Joinson
OBJECTIVES: To identify different patterns (trajectories) of childhood urinary incontinence and examine which patterns are associated with bladder and bowel symptoms in adolescence. DESIGN: Prospective cohort study. SETTING: General community. PARTICIPANTS: The starting sample included 8751 children (4507 men and 4244 women) with parent-reported data on frequency of bedwetting and daytime wetting for at least three of five time points (4½, 5½, 6½, 7½ and 9½ years-hereafter referred to as 4-9 years)...
March 14, 2017: BMJ Open
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