keyword
https://read.qxmd.com/read/38525111/dickkopf-1-drives-perineural-invasion-via-pi3k-akt-signaling-pathway-in-head-and-neck-squamous-cancer
#1
JOURNAL ARTICLE
Jingyi Wang, Qianying Li, Faya Liang, Xin Du, Pan Song, Taowei Wu, Renhui Chen, Xiaorong Lin, Qinglian Liu, Hai Hu, Ping Han, Xiaoming Huang
Perineural invasion (PNI) leads to the poor prognosis of head and neck squamous cancer (HNSCC) patients, but the mechanism of PNI remains unclear. Dickkopf-1 (DKK1), a secretory protein in the Wnt signaling pathway, was found indeed upregulated in HNSCC cells and tissues. Higher expression of DKK1 was statistically relevant to T stage, N stage, PNI, and poor prognosis of HNSCC. DKK1 overexpression enhanced the migration abilities of cancer cells. Moreover, DKK1-overexpressing cancer cells promoted cancer cells invasion of peripheral nerves in vitro and in vivo...
April 2024: MedComm
https://read.qxmd.com/read/38499638/close-negative-correlation-of-local-and-circulating-dickkopf-1-and-sclerostin-levels-during-human-fracture-healing
#2
JOURNAL ARTICLE
Julia Starlinger, Jonas Santol, Georg Kaiser, Kambiz Sarahrudi
Wnt signaling is critically involved in fracture healing. Existing data predominantly relies on rodent models. Here, we explored local and circulating Dickkopf-1 (DKK1) levels in patients with respect to fracture healing and explore its association to sclerostin (SOST). 69 patients after surgical stabilization of long bone fractures of which six patients had impaired fracture healing were included in this study. Life-style and patient related factors with a known effect on DKK1 and SOST were recorded. DKK1 and SOST concentrations were measured using enzyme-linked immunosorbent assay (ELISA) at the fracture site and in circulation...
March 19, 2024: Scientific Reports
https://read.qxmd.com/read/38431439/acquired-curved-hair-is-caused-by-fusion-of-multiple-hair-matrix-cells
#3
JOURNAL ARTICLE
Ippei Horibe, Sara Izumi, Yuru Ke, Nanami Tanahashi, Yusuke Takagi, Ryoji Ishihara, Takaya Nakano, Takaaki Sumiyoshi, Yasuo Nagaoka
BACKGROUND: "Curved hair" caused by acquired factors is considered to have adverse cosmetic effects, but the detailed mechanism behind curved hair remains obscure. OBJECTIVE: We attempted to clarify the causes of curved hair that appeared to have occurred via acquired factors. METHODS: Outer root sheath cells (ORSC) isolated from plucked human hair follicles were used to evaluate the expression of type IV collagen. Straight and curved hairs with hair follicle tissue attached were also collected from the same individuals and subjected to morphological, immunohistochemical, and gene expression analyses...
February 12, 2024: Journal of Dermatological Science
https://read.qxmd.com/read/38400523/icariin-ameliorates-glycolytic-dysfunction-in-alzheimer-s-disease-models-by-activating-the-wnt-%C3%AE-catenin-signaling-pathway
#4
JOURNAL ARTICLE
Ju Liu, Ai-Hong Wei, Ting-Ting Liu, Xin-Hao Ji, Ying Zhang, Fei Yan, Mei-Xiang Chen, Jin-Bo Hu, Shao-Yu Zhou, Jing-Shan Shi, Hai Jin, Feng Jin
It was reported that the Wnt/β-catenin pathway is involved in the regulation of aerobic glycolysis and that brain glycolytic dysfunction results in the development of Alzheimer's disease (AD). Icariin (ICA), an active component extracted from Epimedii Folium, has been reported to produce neuroprotective effects in multiple models of AD, but its underlying mechanism remains to be fully described. We aimed to investigate the protective effects of ICA on animal and cell models of AD and confirm whether the Wnt/β-catenin pathway has functions in the neuroprotective function of ICA...
February 23, 2024: FEBS Journal
https://read.qxmd.com/read/38387686/uptake-of-ox-ldl-by-binding-to-lrp6-mediates-oxidative-stress-induced-bmscs-senescence-promoting-obesity-related-bone-loss
#5
JOURNAL ARTICLE
Senxiong Meng, Zhuan Wang, Xiaonan Liu, Ke Shen, Yuan Gu, Bin Yu, Lei Wang
Obesity has long been thought to a main cause of hyperlipidemia. As a systemic disease, the impact of obesity on organs, tissues and cells are almost all negative. However, the relationship between obesity and bone loss is most controversial. On the one hand, obesity has long been thought to a positive effect on bone due to increased mechanical loading on the skeleton, conducive to increase bone mass to accommodate the extra weight. On the other hand, obesity-related metabolic oxidative modification of low-density lipoprotein (LDL) in vivo caused the gradual increase of oxidized LDL (ox-LDL) in the bone marrow microenvironment...
February 20, 2024: Cellular Signalling
https://read.qxmd.com/read/38376441/dickkopf-1-is-an-immune-infiltration-related-prognostic-biomarker-of-head-and-neck-squamous-cell-carcinoma
#6
JOURNAL ARTICLE
Chaofen Zhao, Lina Liu, Qianyong He, Yuanyuan Li, Jianglong Feng, Yue Chen, Yuxin Li, Xinyu Xu, Shaoyuan Zhu, Yuanmei Ye, Yajing Wen, Zhirui Zeng, Ding'an Zhou, Feng Jin
Immunotherapy is currently one of the most viable therapies for head and neck squamous cell carcinoma (HNSCC), characterized by high immune cell infiltration. The Wnt-signaling inhibitor and immune activation mediator, Dickkopf-1 (DKK1), has a strong correlation with tumor growth, tumor microenvironment, and, consequently, disease prognosis. Nevertheless, it is still unclear how DKK1 expression, HNSCC prognosis, and tumor-infiltrating lymphocytes are related. To better understand these associations, we examined how DKK1 expression varies across different tumor and normal tissues...
February 19, 2024: Aging
https://read.qxmd.com/read/38341461/a-phase-1-2-multicenter-trial-of-dkn-01-as-monotherapy-or-in-combination-with-docetaxel-for-the-treatment-of-metastatic-castration-resistant-prostate-cancer-mcrpc
#7
JOURNAL ARTICLE
David R Wise, Russell K Pachynski, Samuel R Denmeade, Rahul R Aggarwal, Jiehui Deng, Victor Adorno Febles, Arjun V Balar, Minas P Economides, Cynthia Loomis, Shanmugapriya Selvaraj, Michael Haas, Michael H Kagey, Walter Newman, Jason Baum, Andrea B Troxel, Sarah Griglun, Dayna Leis, Nina Yang, Viktoriya Aranchiy, Sabrina Machado, Erika Waalkes, Gabrielle Gargano, Nadia Soamchand, Amrutesh Puranik, Pratip Chattopadhyay, Ezeddin Fedal, Fang-Ming Deng, Qinghu Ren, Luis Chiriboga, Jonathan Melamed, Cynthia A Sirard, Kwok-Kin Wong
BACKGROUND: Dickkopf-related protein 1 (DKK1) is a Wingless-related integrate site (Wnt) signaling modulator that is upregulated in prostate cancers (PCa) with low androgen receptor expression. DKN-01, an IgG4 that neutralizes DKK1, delays PCa growth in pre-clinical DKK1-expressing models. These data provided the rationale for a clinical trial testing DKN-01 in patients with metastatic castration-resistant PCa (mCRPC). METHODS: This was an investigator-initiated parallel-arm phase 1/2 clinical trial testing DKN-01 alone (monotherapy) or in combination with docetaxel 75 mg/m2 (combination) for men with mCRPC who progressed on ≥1 AR signaling inhibitors...
February 10, 2024: Prostate Cancer and Prostatic Diseases
https://read.qxmd.com/read/38322254/spatial-gene-expression-profile-of-wnt-signaling-components-in-the-murine-enteric-nervous-system
#8
JOURNAL ARTICLE
Melanie Scharr, Bernhard Hirt, Peter H Neckel
INTRODUCTION: Wnt-signaling is a key regulator of stem cell homeostasis, extensively studied in the intestinal crypt and other metazoan tissues. Yet, there is hardly any data available on the presence of Wnt-signaling components in the adult enteric nervous system (ENS) in vivo . METHODS: Therefore, we employed RNAscope HiPlex-assay, a novel and more sensitive in situ hybridization technology. By amplifying target specific signals, this technique enables the detection of low abundance, tightly regulated RNA content as is the case for Wnt-signaling components...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38285009/downregulation-of-dickkopf-3-a-wnt-antagonist-elevated-in-alzheimer-s-disease-restores-synapse-integrity-and-memory-in-a-disease-mouse-model
#9
JOURNAL ARTICLE
Nuria Martin Flores, Marina Podpolny, Faye McLeod, Isaac Workman, Karen Crawford, Dobril Ivanov, Ganna Leonenko, Valentina Escott-Price, Patricia C Salinas
Increasing evidence supports a role for deficient Wnt signaling in Alzheimer's disease (AD). Studies reveal that the secreted Wnt antagonist Dickkopf-3 (DKK3) colocalizes to amyloid plaques in AD patients. Here, we investigate the contribution of DKK3 to synapse integrity in healthy and AD brains. Our findings show that DKK3 expression is upregulated in the brains of AD subjects and that DKK3 protein levels increase at early stages in the disease. In hAPP-J20 and hAPPNL-G-F/NL-G-F mouse AD models, extracellular DKK3 levels are increased and DKK3 accumulates at dystrophic neuronal processes around plaques...
January 29, 2024: ELife
https://read.qxmd.com/read/38268623/role-of-prognostic-gene-dkk1-in-oral-squamous-cell-carcinoma
#10
JOURNAL ARTICLE
Yujiao Liu, Congcong Wei, Song Wang, Shuxin Ding, Yanan Li, Yongguo Li, Dongping Zhang, Guoxiong Zhu, Zhen Meng
Oral squamous cell carcinoma (OSCC) is one of the most common squamous cell carcinomas of the head and neck. The morbidity and mortality rates of OSCC have increased in recent years. However, the pathogenesis of this disease remains unknown. The present study aimed to identify predictive biomarkers and therapeutic targets for OSCC. Bioinformatics screening of differentially expressed genes in OSCC was performed based on data from The Cancer Genome Atlas and Gene Expression Omnibus databases. Dickkopf Wnt signaling pathway inhibitor 1 (DKK1) was identified to be associated with survival, tumor immunity and DNA repair in OSCC...
February 2024: Oncology Letters
https://read.qxmd.com/read/38233008/dkk-1-in-psoriatic-arthritis-correlation-with-disease-activity-and-enthesopathy
#11
JOURNAL ARTICLE
Marian Aziz Wahba Abdo Wahba, Nagat Mohamed El-Gazzar, Radwa Mahmoud Elsharaby, Samar Abdalhamed Tabra
BACKGROUND: Psoriatic arthritis (PsA) is a complex inflammatory disease with varied clinical characteristics. A pathognomonic characteristic of PsA is enthesitis. Entheseal inflammation ultimately leads to the production of new bone (enthesophytes). Dickkopf-related protein-1 (DKK-1) is a wingless (Wnt) inhibitor that inhibits osteoblast function. OBJECTIVES: Assessment of the serum level of DKK-1 and its association with disease activity and enthesopathy in PsA patients...
January 2024: Reumatología clinica
https://read.qxmd.com/read/38218948/mir-181a-5p-knockdown-ameliorates-sevoflurane-anesthesia-induced-neuron-injury-via-regulation-of-the-ddx3x-wnt-%C3%AE-catenin-signaling-axis
#12
JOURNAL ARTICLE
Yuqi She, Zhijun Chen, Li Zhang, Yuan Wang
Sevoflurane is one of the most widely used inhaled anesthetics. MicroRNAs (miRNAs) have been demonstrated to affect sevoflurane anesthesia-induced neuron damage. The purpose of this study was to investigate the role and mechanism of miR-181a-5p in sevoflurane-induced hippocampal neuronal injury. Primary hippocampal neurons were identified using microscopy and immunofluorescence. The viability and apoptosis of sevoflurane anesthesia-induced neurons were detected by cell counting kit-8 (CCK-8) assay and terminal-deoxynucleoitidyl transferase-mediated nick end-labeling (TUNEL) staining assay, respectively...
January 13, 2024: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://read.qxmd.com/read/38201279/the-multifaceted-role-of-human-dickkopf-3-dkk-3-in-development-immune-modulation-and-cancer
#13
REVIEW
Jana Mourtada, Chloé Thibaudeau, Bohdan Wasylyk, Alain C Jung
The human Dickkopf (DKK) family includes four main secreted proteins, DKK-1, DKK-2, DKK-3, and DKK-4, as well as the DKK-3 related protein soggy (Sgy-1 or DKKL1). These glycoproteins play crucial roles in various biological processes, and especially modulation of the Wnt signaling pathway. DKK-3 is distinct, with its multifaceted roles in development, stem cell differentiation and tissue homeostasis. Intriguingly, DKK-3 appears to have immunomodulatory functions and a complex role in cancer, acting as either a tumor suppressor or an oncogene, depending on the context...
December 29, 2023: Cells
https://read.qxmd.com/read/38186869/dkk3-as-a-potential-novel-biomarker-in-patients-with-autosomal-polycystic-kidney-disease
#14
JOURNAL ARTICLE
Sita Arjune, Martin R Späth, Simon Oehm, Polina Todorova, Stefan J Schunk, Katharina Lettenmeier, Seung-Hun Chon, Malte P Bartram, Philipp Antczak, Franziska Grundmann, Danilo Fliser, Roman-Ulrich Müller
BACKGOUND: Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease, and leads to a steady loss of kidney function in adulthood. The variable course of the disease makes it necessary to identify the patients with rapid disease progression who will benefit the most from targeted therapies and interventions. Currently, magnetic resonance imaging-based volumetry of the kidney is the most commonly used tool for this purpose. Biomarkers that can be easily and quantitatively determined, which allow a prediction of the loss of kidney function, have not yet been established in clinical practice...
January 2024: Clinical Kidney Journal
https://read.qxmd.com/read/38178019/integrated-analysis-strategy-of-genome-wide-functional-gene-mining-reveals-dkk2-gene-underlying-meat-quality-in-shaziling-synthesized-pigs
#15
JOURNAL ARTICLE
Shuaihan He, Yubei Wang, Yabiao Luo, Mingming Xue, Maisheng Wu, Hong Tan, Yinglin Peng, Kejun Wang, Meiying Fang
BACKGROUND: Shaziling pig is a well-known indigenous breed in China who has superior meat quality traits. However, the genetic mechanism and genomic evidence underlying meat quality characteristics of Shaziling pigs are still unclear. To explore and investigate the germplasm characteristics of Shaziling pigs, we totally analyzed 67 individual's whole genome sequencing data for the first time (20 Shaziling pigs [S], 20 Dabasha pigs [DBS], 11 Yorkshire pigs [Y], 10 Berkshire pigs [BKX], 5 Basha pigs [BS] and 1 Warthog)...
January 4, 2024: BMC Genomics
https://read.qxmd.com/read/38152853/inhibition-of-a-novel-dickkopf-1-ldl-receptor-related-proteins-5-and-6-axis-prevents-diabetic-cardiomyopathy-in-mice
#16
JOURNAL ARTICLE
En Ma, Da Wo, Jinxiao Chen, Hongwei Yan, Xiaohui Zhou, Jia He, Celiang Wu, Qing Wang, Changjing Zuo, Xiao Li, Li Li, Qingshu Meng, Liang Zheng, Luying Peng, Lidian Chen, Jun Peng, Dan-Ni Ren, Weidong Zhu
BACKGROUND AND AIMS: Anti-hypertensive agents are one of the most frequently used drugs worldwide. However, no blood pressure-lowering strategy is superior to placebo with respect to survival in diabetic hypertensive patients. Previous findings show that Wnt co-receptors LDL receptor-related proteins 5 and 6 (LRP5/6) can directly bind to several G protein-coupled receptors (GPCRs). Because angiotensin II type 1 receptor (AT1R) is the most important GPCR in regulating hypertension, this study examines the possible mechanistic association between LRP5/6 and their binding protein Dickkopf-1 (DKK1) and activation of the AT1R and further hypothesizes that the LRP5/6-GPCR interaction may affect hypertension and potentiate cardiac impairment in the setting of diabetes...
December 28, 2023: European Heart Journal
https://read.qxmd.com/read/38073341/dickkopf-related-protein-1-as-a-biomarker-of-local-immune-status-and-worse-prognosis-of-oral-squamous-cell-carcinoma
#17
JOURNAL ARTICLE
Dong-Xu Liu, Ke-Han Wu, Xi-Yan Zang, Jia-Yi Lu, Ming-Yue Liu, Chun-Ming Li, Li Gao
BACKGROUND: Oral squamous cell carcinoma (OSCC) is an infiltrative malignancy characterized by a significantly elevated recurrence rate. Dickkopf-related protein 1 (DKK1), which plays an oncogene role in many cancers, acts as an inhibitor of the Wingless protein (Wnt) signaling pathway. Currently, there is a lack of consensus regarding the role of DKK1 in OSCC or its clinical significance. OBJECTIVE: To examine the role and effect of DKK1 in OSCC. METHODS: The identification of differentially expressed genes (DEGs) in OSCC was conducted by utilizing databases such as The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO)...
November 23, 2023: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://read.qxmd.com/read/38067123/effects-of-dickkopf-1-dkk-1-on-prostate-cancer-growth-and-bone-metastasis
#18
JOURNAL ARTICLE
Shiyu Yuan, Nathan K Hoggard, Noriko Kantake, Blake E Hildreth, Thomas J Rosol
Osteoblastic bone metastases are commonly detected in patients with advanced prostate cancer (PCa) and are associated with an increased mortality rate. Dickkopf-1 (DKK-1) antagonizes canonical WNT/β-catenin signaling and plays a complex role in bone metastases. We explored the function of cancer cell-specific DKK-1 in PCa growth, metastasis, and cancer-bone interactions using the osteoblastic canine PCa cell line, Probasco. Probasco or Probasco + DKK-1 (cells transduced with human DKK-1 ) were injected into the tibia or left cardiac ventricle of athymic nude mice...
November 24, 2023: Cells
https://read.qxmd.com/read/38012711/inhibition-of-dickkopf-1-enhances-the-anti-tumor-efficacy-of-sorafenib-via-inhibition-of-the-pi3k-akt-and-wnt-%C3%AE-catenin-pathways-in-hepatocellular-carcinoma
#19
JOURNAL ARTICLE
Sang Hyun Seo, Kyung Joo Cho, Hye Jung Park, Hye Won Lee, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Jae Hee Cheon, Jong In Yook, Man-Deuk Kim, Dong Jin Joo, Seung Up Kim
BACKGROUND: Sorafenib improves the overall survival in patients with advanced hepatocellular carcinoma (HCC). Dickkopf-1 (DKK1) is commonly overexpressed in HCC. In this study, we investigated whether the inhibition of DKK1 enhances the anti-tumor efficacy of sorafenib in HCC. METHODS: HCC cells were treated with sorafenib and WAY-262611, which is an inhibitor of DKK1. Transgenic mouse models were also developed using hydrodynamic tail vein injection. Mice were orally administered with sorafenib (32 mg/kg), WAY-262611 (16 mg/kg), or sorafenib + WAY-262611 for 10 days...
November 27, 2023: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/37999432/sex-differences-in-bone-muscle-and-inflammatory-markers-and-their-associations-with-muscle-performance-variables
#20
JOURNAL ARTICLE
Pragya Sharma Ghimire, Adam Eckart, Ibtihal K Al-Makhzoomy, James Stavitz
The importance of various markers such as Sclerostin, Dickkopf-1 (DKK-1), Irisin, receptor activator of NF-kB ligand (RANKL), and Vitamin D have been well studied in bone metabolism. Additionally, inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and Interleukin 6 (IL-6) have been shown to hinder muscle protein synthesis, leading to the loss of muscle and strength. However, a research gap exists in understanding their role in muscle function and physical activity. Therefore, this study aims to explore the serum levels of Sclerostin, DKK-1, Irisin, IL-6, RANKL, Vitamin D, and TNF-α and assess their relationships with upper- and lower-body strength in young adults...
November 6, 2023: Sports
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