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https://www.readbyqxmd.com/read/29130381/lymph-node-metastases-as-only-qualifier-for-stage-iv-serous-ovarian-cancer-confers-longer-survival-than-other-sites-of-distant-disease-a-swedish-gynecologic-cancer-group-swegcg-study
#1
Elisabet Hjerpe, Christian Staf, Pernilla Dahm-Kähler, Karin Stålberg, Maria Bjurberg, Erik Holmberg, Christer Borgfeldt, Bengt Tholander, Kristina Hellman, Preben Kjølhede, Thomas Högberg, Per Rosenberg, Elisabeth Åvall-Lundqvist
BACKGROUND: The International Federation of Gynecology and Obstetrics (FIGO) ovarian cancer staging system includes no sub-stage for lymph nodes (LN) as only distant disease manifestation. We explore the prognostic implication of LN as only stage IV classifier in serous ovarian cancer. METHOD: This is a nation-wide, population-based study on 551 women with serous stage IV cancers diagnosed between 2009-2014. We compare overall survival (OS) in women with LN as only distant metastatic site to those with pleural metastases only and to patients with other/multiple stage IV manifestations...
November 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29120997/waterborne-disease-outbreaks-associated-with-environmental-and-undetermined-exposures-to-water-united-states-2013-2014
#2
R Paul McClung, David M Roth, Marissa Vigar, Virginia A Roberts, Amy M Kahler, Laura A Cooley, Elizabeth D Hilborn, Timothy J Wade, Kathleen E Fullerton, Jonathan S Yoder, Vincent R Hill
Waterborne disease outbreaks in the United States are associated with a wide variety of water exposures and are reported annually to CDC on a voluntary basis by state and territorial health departments through the National Outbreak Reporting System (NORS). A majority of outbreaks arise from exposure to drinking water (1) or recreational water (2), whereas others are caused by an environmental exposure to water or an undetermined exposure to water. During 2013-2014, 15 outbreaks associated with an environmental exposure to water and 12 outbreaks with an undetermined exposure to water were reported, resulting in at least 289 cases of illness, 108 hospitalizations, and 17 deaths...
November 10, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29120680/a-clinical-evaluation-of-a-transparent-absorbent-adhesive-wound-dressing
#3
Lotta von Cramon, Marta Markowicz, Jan Nebendahl, Verena-Constanze Buchinger-Kähler, Ernst Magnus Noah, Mustafa Narwan, Anika Behrendt, Norbert Pallua, Amrei Steinhoff
The performance of a transparent absorbent adhesive wound dressing (TAAWD) was observed over 7 days in five plastic surgery clinics across Germany. The study included 47 diverse postoperative linear wounds and donor sites with dry or minimal exudate levels. Data on ease of application and removal, adhesive strength, skin compatibility, conformability to the body, visual wound inspection and parameters of wound assessment were collected and analysed. At the end of the observation period, 100% of wounds were recorded as healing with no reported complications...
November 8, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29117697/non-orthogonal-internally-contracted-multi-configurational-perturbation-theory-nicpt-dynamic-electron-correlation-for-large-compact-active-spaces
#4
Sven Kähler, Jeppe Olsen
A computational method is presented for systems that require high-level treatments of static and dynamic electron correlation but cannot be treated using conventional complete active space self-consistent field-based methods due to the required size of the active space. Our method introduces an efficient algorithm for perturbative dynamic correlation corrections for compact non-orthogonal MCSCF calculations. In the algorithm, biorthonormal expansions of orbitals and CI-wave functions are used to reduce the scaling of the performance determining step from quadratic to linear in the number of configurations...
November 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29108353/evaluation-of-real-world-treatment-outcomes-in-patients-with-distant-metastatic-merkel-cell-carcinoma-following-second-line-chemotherapy-in-europe
#5
Jürgen C Becker, Eva Lorenz, Selma Ugurel, Thomas K Eigentler, Felix Kiecker, Claudia Pföhler, Ivonne Kellner, Friedegund Meier, Katharina Kähler, Peter Mohr, Carola Berking, Gabriele Haas, Christoph Helwig, Dina Oksen, Dirk Schadendorf, Lisa Mahnke, Murtuza Bharmal
Background and aims: Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer; few treatments exist for patients with advanced disease. Once tumors metastasize to distant sites, patients generally receive chemotherapy, but response duration and progression-free survival (PFS) are typically short. Few studies have assessed the efficacy of second-line chemotherapy for metastatic MCC. Here, we studied outcomes in patients who received ≥ 2 lines of chemotherapy for metastatic MCC. Materials and methods: Patients in an MCC-specific registry diagnosed with stage IV MCC between November 1, 2004, and September 15, 2015, and treated with second-line or later chemotherapy were analyzed retrospectively...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29100289/chemosensitivity-directed-therapy-compared-to-dacarbazine-in-chemo-naive-advanced-metastatic-melanoma-a-multicenter-randomized-phase-3-decog-trial
#6
Selma Ugurel, Carmen Loquai, Patrick Terheyden, Dirk Schadendorf, Erika Richtig, Jochen Utikal, Ralf Gutzmer, Knuth Rass, Cord Sunderkötter, Annette Stein, Michael Fluck, Martin Kaatz, Uwe Trefzer, Katharina Kähler, Rudolf Stadler, Carola Berking, Christoph Höller, Laura Kerschke, Lutz Edler, Annette Kopp-Schneider, Jürgen C Becker
Chemotherapy still plays an important role in metastatic melanoma, particularly for patients who are not suitable or have no access to highly efficacious new therapies. Pre-therapeutic chemosensitivity testing might be useful to identify optimal chemotherapy regimens for individual patients. This multicenter randomized phase-3 trial was aimed to test for superiority of chemosensitivity-directed combination chemotherapy compared to standard dacarbazine monochemotherapy, and to demonstrate the chemosensitivity test result as prognostic in metastatic melanoma...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29099082/mineral-trioxide-aggregate-a-review-of-properties-and-testing-methodologies
#7
REVIEW
William N Ha, Timothy Nicholson, Bill Kahler, Laurence J Walsh
Mineral trioxide aggregate (MTA) restoratives and MTA sealers are commonly used in endodontics. Commonly referenced standards for testing of MTA are ISO 6876, 9917-1 and 10993. A PubMed search was performed relating to the relevant tests within each ISO and "mineral trioxide aggregate". MTA restoratives are typically tested with a mixture of tests from multiple standards. As the setting of MTA is dependent upon hydration, the results of various MTA restoratives and sealers are dependent upon the curing methodology...
November 2, 2017: Materials
https://www.readbyqxmd.com/read/29065137/differences-in-the-population-structure-of-neisseria-meningitidis-in-two-australian-states-victoria-and-western-australia
#8
Shakeel Mowlaboccus, Christopher A Mullally, Peter C Richmond, Benjamin P Howden, Kerrie Stevens, David J Speers, Anthony D Keil, Ottar N Bjørnstad, Timothy T Perkins, Charlene M Kahler
Neisseria meningitidis is the causative agent of invasive meningococcal disease (IMD). A recombinant vaccine called Bexsero® incorporates four subcapsular antigens (fHbp, NHBA, NadA and PorA) which are used to assign a Bexsero® antigen sequence type (BAST) to each meningococcal strain. The vaccine elicits an immune response against combinations of variants of these antigens which have been grouped into specific BAST profiles that have been shown to have different distributions within geographical locations thus potentially affecting the efficacy of the vaccine...
2017: PloS One
https://www.readbyqxmd.com/read/29064355/assessment-of-drinking-water-sold-from-private-sector-kiosks-in-post-earthquake-port-au-prince-haiti
#9
Molly Patrick, Maria Steenland, Amber Dismer, Jocelyne Pierre-Louis, Jennifer L Murphy, Amy Kahler, Bonnie Mull, Melissa D Etheart, Emmanuel Rossignol, Jacques Boncy, Vincent Hill, Thomas Handzel
Consumption of drinking water from private vendors has increased considerably in Port-au-Prince, Haiti, in recent decades. A major type of vendor is private kiosks, advertising reverse osmosis-treated water for sale by volume. To describe the scale and geographical distribution of private kiosks in metropolitan Port-au-Prince, an inventory of private kiosks was conducted from July to August 2013. Coordinates of kiosks were recorded with global positioning system units and a brief questionnaire was administered with the operator to document key kiosk characteristics...
October 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29031004/starting-a-uterus-transplantation-service-notes-from-a-small-island
#10
Hak-Koon Tan, Bien-Keem Tan, Lay-Kok Tan, Jan I Olofsson, Pernilla Dahm-Kähler, Mats Brännström
Once thought as an impossibility, uterus transplantation (UTx) is now very much a reality and is being offered as a clinical service in several countries, including Sweden that pioneered this new field of infertility treatment with their initial clinical trial in 2013. (1) A majority of the women in that trial has given birth to one or more babies. Unlike conventional solid organ transplantation, UTx is an ephemeral transplant: the sole purpose of grafting the uterus is for the recipient to conceive and have offspring and the uterus can then be removed...
October 14, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28981379/a-pilot-randomized-controlled-trial-of-a-computer-delivered-brief-intervention-for-substance-use-and-risky-sex-during-pregnancy
#11
Golfo Tzilos Wernette, Melissa Plegue, Christopher W Kahler, Ananda Sen, Caron Zlotnick
BACKGROUND: Sexually transmitted infections (STIs) are an increasingly critical and costly health problem for American childbearing women. Pregnant women who misuse substances are more likely to engage in risky sexual behavior that leads to STIs. Substance use and risky sex during pregnancy are both associated with numerous negative consequences for the woman and the developing fetus. STUDY DESIGN: A two-group, randomized controlled trial. PARTICIPANTS: Recruitment of 50 pregnant women (30% Latina; 24...
October 5, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28970225/environmental-survey-of-drinking-water-sources-in-kampala-uganda-during-a-typhoid-fever-outbreak
#12
J L Murphy, A M Kahler, I Nansubuga, E M Nanyunja, B Kaplan, N Jothikumar, J Routh, G A Gómez, E D Mintz, V R Hill
In 2015, a typhoid fever outbreak began in downtown Kampala, Uganda and spread into adjacent districts. In response, an environmental survey of drinking water source types was conducted in areas of the city with high case numbers. A total of 122 samples were collected from 12 source types and tested for E. coli, free chlorine, and conductivity. An additional 37 grab samples from seven source types and 16 paired large volume (20-L) samples from wells and springs were also collected and tested for the presence of Salmonella Typhi...
September 29, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28961175/alkaline-sodium-hypochlorite-irrigant-and-its-chemical-interactions
#13
REVIEW
Patricia P Wright, Bill Kahler, Laurence J Walsh
Endodontic irrigating solutions may interact chemically with one another. This is important, because even when solutions are not admixed, they will come into contact with one another during an alternating irrigation technique, forming unwanted by-products, which may be toxic or irritant. Mixing or alternating irrigants can also reduce their ability to clean and disinfect the root canal system of teeth by changing their chemical structure with subsequent loss of the active agent, or by inducing precipitate formation in the root canal system...
September 29, 2017: Materials
https://www.readbyqxmd.com/read/28956168/continuity-of-midwifery-carer-moderates-the-effects-of-prenatal-maternal-stress-on-postnatal-maternal-wellbeing-the-queensland-flood-study
#14
Sue Kildea, Gabrielle Simcock, Aihua Liu, Guillaume Elgbeili, David P Laplante, Adele Kahler, Marie-Paule Austin, Sally Tracy, Sue Kruske, Mark Tracy, Michael W O'Hara, Suzanne King
Poor postnatal mental health is a major public health issue, and risk factors include experiencing adverse life events during pregnancy. We assessed whether midwifery group practice, compared to standard hospital care, would protect women from the negative impact of a sudden-onset flood on postnatal depression and anxiety. Women either received midwifery group practice care in pregnancy, in which they were allocated a primary midwife who provided continuity of care, or they received standard hospital care provided by various on-call and rostered medical staff...
September 27, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/28950303/checkpoint-blockade-for-metastatic-melanoma-and-merkel-cell-carcinoma-in-hiv-positive-patients
#15
M V Heppt, M Schlaak, T K Eigentler, K C Kähler, F Kiecker, C Loquai, F Meier, D Tomsitz, N Brenner, A C Niesert, R Thonke, A Hauschild, C Berking
No abstract text is available yet for this article.
September 18, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28941898/interlaboratory-validation-of-an-improved-method-for-detection-of-cyclospora-cayetanensis-in-produce-using-a-real-time-pcr-assay
#16
Helen R Murphy, Hediye Nese Cinar, Gopal Gopinath, Kathy E Noe, Lacresha D Chatman, Nancy E Miranda, June H Wetherington, Jason Neal-McKinney, Gabrielle S Pires, Elizabeth Sachs, Kristopher J Stanya, Cynthia L Johnson, Fernanda S Nascimento, Monica Santin, Aleksey Molokin, Mansour Samadpour, Harish Janagama, Amy Kahler, Candace Miller, Alexandre J da Silva
A collaborative validation study was performed to evaluate the performance of a new U.S. Food and Drug Administration method developed for detection of the protozoan parasite, Cyclospora cayetanensis, on cilantro and raspberries. The method includes a sample preparation step in which oocysts are recovered from produce using an enhanced produce washing solution containing 0.1% Alconox and a commercially available method to disrupt the C. cayetanensis oocysts and extract DNA. A real-time PCR assay targeting the C...
February 2018: Food Microbiology
https://www.readbyqxmd.com/read/28938733/a-phase-iii-randomized-controlled-trial-comparing-the-efficacy-safety-and-tolerability-of-oral-dydrogesterone-versus-micronized-vaginal-progesterone-for-luteal-support-in-in-vitro-fertilization
#17
Herman Tournaye, Gennady T Sukhikh, Elke Kahler, Georg Griesinger
No abstract text is available yet for this article.
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28934108/markers-of-microbial-translocation-and-immune-activation-predict-cognitive-processing-speed-in-heavy-drinking-men-living-with-hiv
#18
Mollie A Monnig, Christopher W Kahler, Patricia A Cioe, Peter M Monti, Kenneth H Mayer, David W Pantalone, Ronald A Cohen, Bharat Ramratnam
HIV infection and alcohol use disorder are associated with deficits in neurocognitive function. Emerging evidence points to pro-inflammatory perturbations of the gut-brain axis as potentially contributing to neurocognitive impairment in the context of HIV and chronic heavy alcohol use. This study examined whether plasma markers of microbial translocation (LPS) from the gastrointestinal tract and related immune activation (sCD14, EndoCAb) were associated with neurocognition in 21 men living with HIV who were virally suppressed on antiretroviral therapy...
September 21, 2017: Microorganisms
https://www.readbyqxmd.com/read/28928766/genetics-of-tinnitus-time-to-biobank-phantom-sounds
#19
Christopher R Cederroth, Anna K Kähler, Patrick F Sullivan, Jose A Lopez-Escamez
Tinnitus is a common phantom sensation resulting most often from sensory deprivation, and for which little knowledge on the molecular mechanisms exists. While the existing evidence for a genetic influence on the condition has been until now sparse and underpowered, recent data suggest that specific forms of tinnitus have a strong genetic component revealing that not all tinnitus percepts are alike, at least in how they are genetically driven. These new findings pave the way for a better understanding on how phantom sensations are molecularly driven and call for international biobanking efforts...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28875876/commercial-herbal-medicines-used-as-african-traditional-medicines-ngoma-herbal-tonic-immune-booster-interferes-with-a-rapid-urine-drug-screening-test
#20
M E Mothibe, E Osuch, C P Kahler-Venter
BACKGROUND: The prevalent use of African traditional medicine by the general public has been reported. With commercialisation and marketing, some of the herbal medicines (HMs) used are readily available over the counter, most of them promoted as immune boosters. These commercial HMs have not been taken through clinical trials and other tests that would validate their composition and safety, and other properties such as their effect on laboratory diagnostic tests. OBJECTIVE: To investigate the cross-reactivity of selected HMs with commonly tested drugs of abuse (DoA) using a qualitative rapid urinalysis assay...
August 25, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
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