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https://www.readbyqxmd.com/read/29771877/cholera-epidemic-lusaka-zambia-october-2017-may-2018
#1
Nyambe Sinyange, Joan M Brunkard, Nathan Kapata, Mazyanga Lucy Mazaba, Kunda G Musonda, Raymond Hamoonga, Muzala Kapina, Fred Kapaya, Lwito Mutale, Ernest Kateule, Francis Nanzaluka, James Zulu, Chileshe Lukwesa Musyani, Alison V Winstead, William W Davis, Hammad S N'cho, Nelia L Mulambya, Patrick Sakubita, Orbie Chewe, Sulani Nyimbili, Ezinne V C Onwuekwe, Nedghie Adrien, Anna J Blackstock, Travis W Brown, Gordana Derado, Nancy Garrett, Sunkyung Kim, Sydney Hubbard, Amy M Kahler, Warren Malambo, Eric Mintz, Jennifer Murphy, Rupa Narra, Gouthami G Rao, Margaret A Riggs, Nicole Weber, Ellen Yard, Khozya D Zyambo, Nathan Bakyaita, Namani Monze, Kennedy Malama, Jabbin Mulwanda, Victor M Mukonka
On October 6, 2017, an outbreak of cholera was declared in Zambia after laboratory confirmation of Vibrio cholerae O1, biotype El Tor, serotype Ogawa, from stool specimens from two patients with acute watery diarrhea. The two patients had gone to a clinic in Lusaka, the capital city, on October 4. Cholera cases increased rapidly, from several hundred cases in early December 2017 to approximately 2,000 by early January 2018 (Figure). In collaboration with partners, the Zambia Ministry of Health (MoH) launched a multifaceted public health response that included increased chlorination of the Lusaka municipal water supply, provision of emergency water supplies, water quality monitoring and testing, enhanced surveillance, epidemiologic investigations, a cholera vaccination campaign, aggressive case management and health care worker training, and laboratory testing of clinical samples...
May 18, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29771872/outbreaks-associated-with-treated-recreational-water-united-states-2000-2014
#2
Michele C Hlavsa, Bryanna L Cikesh, Virginia A Roberts, Amy M Kahler, Marissa Vigar, Elizabeth D Hilborn, Timothy J Wade, Dawn M Roellig, Jennifer L Murphy, Lihua Xiao, Kirsten M Yates, Jasen M Kunz, Matthew J Arduino, Sujan C Reddy, Kathleen E Fullerton, Laura A Cooley, Michael J Beach, Vincent R Hill, Jonathan S Yoder
Outbreaks associated with exposure to treated recreational water can be caused by pathogens or chemicals in venues such as pools, hot tubs/spas, and interactive water play venues (i.e., water playgrounds). During 2000-2014, public health officials from 46 states and Puerto Rico reported 493 outbreaks associated with treated recreational water. These outbreaks resulted in at least 27,219 cases and eight deaths. Among the 363 outbreaks with a confirmed infectious etiology, 212 (58%) were caused by Cryptosporidium (which causes predominantly gastrointestinal illness), 57 (16%) by Legionella (which causes Legionnaires' disease, a severe pneumonia, and Pontiac fever, a milder illness with flu-like symptoms), and 47 (13%) by Pseudomonas (which causes folliculitis ["hot tub rash"] and otitis externa ["swimmers' ear"])...
May 18, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29750362/brief-motivational-intervention-for-underage-young-adult-drinkers-results-from-a-randomized-clinical-trial
#3
Suzanne M Colby, Lindsay Orchowski, Molly Magill, James G Murphy, Linda A Brazil, Timothy R Apodaca, Christopher W Kahler, Nancy P Barnett
BACKGROUND: While there is a substantial literature on the efficacy of brief motivational intervention (BMI) for college student drinkers, research has focused less on young adults who do not attend a four-year college, despite their elevated risk for excessive alcohol use and associated harmful consequences. METHODS: This randomized controlled trial (NCT01546025) compared the efficacy of BMI to a time-matched attention control intervention (Relaxation Training; REL) for reducing alcohol consumption and related negative consequences in an underage young adult sample...
May 11, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29657578/notes-from-the-field-a-case-of-hepatic-failure-and-reflections-on-current-status-of-healthcare-of-syrian-refugees-in-lebanon
#4
Salim M Saiyed, John Kahler, Mutaz Kalabani
Recent trends and research suggest health conditions of the Syrian refugees in Lebanon are deteriorating. The following case study highlights some of the problems that refugees encounter seeking health care services in Lebanon. A coordinated response from Non-governmental organization (NGO) with intense focus on non-communicable disease (NCD) is needed to avert further worsening of health conditions on the ground.
2018: Conflict and Health
https://www.readbyqxmd.com/read/29606791/on-the-effective-field-theory-of-heterotic-vacua
#5
Jock McOrist
The effective field theory of heterotic vacua that realise [Formula: see text] preserving [Formula: see text] supersymmetry is studied. The vacua in question admit large radius limits taking the form [Formula: see text], with [Formula: see text] a smooth threefold with vanishing first Chern class and a stable holomorphic gauge bundle [Formula: see text]. In a previous paper we calculated the kinetic terms for moduli, deducing the moduli metric and Kähler potential. In this paper, we compute the remaining couplings in the effective field theory, correct to first order in [Formula: see text]...
2018: Letters in Mathematical Physics
https://www.readbyqxmd.com/read/29557825/robotic-vs-open-surgery-for-endometrial-cancer-in-elderly-patients-surgical-outcome-survival-and-cost-analysis
#6
Anna Lindfors, Åsa Åkesson, Christian Staf, Per Sjöli, Karin Sundfeldt, Pernilla Dahm-Kähler
OBJECTIVE: This study aimed to compare robotic and open surgery in elderly women diagnosed as having endometrial cancer, in terms of costs, survival, surgical outcome, and operating time. METHODS: Women 70 years or older undergoing open and robotic surgery for endometrial cancers were included consecutively before and after the introduction of robotic surgery at a tertiary center. Costs were calculated using the case-costing system, cost per patient, including the first 30 postoperative days...
March 20, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29548190/clogging-in-constricted-suspension-flows
#7
Alvaro Marin, Henri Lhuissier, Massimiliano Rossi, Christian J Kähler
The flow of a charged-stabilized suspension through a single constricted channel is studied experimentally by tracking the particles individually. Surprisingly, the behavior is found to be qualitatively similar to that of inertial dry granular systems: For small values of the neck-to-particle size ratio (D/d<3), clogs form randomly as arches of the particle span the constriction. The statistics of the clogging events are Poissonian as reported for granular systems and agree for moderate particle volume fraction (ϕ≈20%) with a simple stochastic model for the number of particles at the neck...
February 2018: Physical Review. E
https://www.readbyqxmd.com/read/29517285/multidrug-resistant-neisseria-gonorrhoeae-future-therapeutic-options
#8
Charlene M Kahler
No abstract text is available yet for this article.
April 2018: Future Microbiology
https://www.readbyqxmd.com/read/29487980/ipilimumab-in-metastatic-melanoma-patients-with-pre-existing-autoimmune-disorders
#9
Katharina C Kähler, Thomas K Eigentler, Anja Gesierich, Lucie Heinzerling, Carmen Loquai, Friedegund Meier, Frank Meiss, Claudia Pföhler, Max Schlaak, Patrick Terheyden, Kai M Thoms, Mirjana Ziemer, Lisa Zimmer, Ralf Gutzmer
BACKGROUND: Ipilimumab and programmed death (PD) 1-antibodies are effective treatment options in metastatic melanoma. The safety and efficacy of ipilimumab in patients with pre-existing autoimmune disorders (AD) has only been evaluated in a selected number of patients. METHODS: We performed a retrospective analysis in 14 German skin cancer centers for patients with metastatic melanoma and pre-existing AD treated with ipilimumab. RESULTS: 41 patients with 44 pre-existing AD were treated with ipilimumab (thyroiditis n = 15, rheumatoid n = 11, dermatologic n = 10, Crohn's disease/ulcerative colitis n = 3, neurological n = 2, sarcoidosis n = 2, pancreatitis n = 1)...
May 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29482499/genomic-epidemiology-and-population-structure-of-neisseria-gonorrhoeae-from-remote-highly-endemic-western-australian-populations
#10
Barakat A Al Suwayyid, Geoffrey W Coombs, David J Speers, Julie Pearson, Michael J Wise, Charlene M Kahler
BACKGROUND: Neisseria gonorrhoeae causes gonorrhoea, the second most commonly notified sexually transmitted infection in Australia. One of the highest notification rates of gonorrhoea is found in the remote regions of Western Australia (WA). Unlike isolates from the major Australian population centres, the remote community isolates have low rates of antimicrobial resistance (AMR). Population structure and whole-genome comparison of 59 isolates from the Western Australian N. gonorrhoeae collection were used to investigate relatedness of isolates cultured in the metropolitan and remote areas...
February 27, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29451723/clickable-polyamine-derivatives-as-chemical-probes-for-the-polyamine-transport-system
#11
Roeland Vanhoutte, Jan Pascal Kahler, Shaun Martin, Sarah van Veen, Steven H L Verhelst
Polyamines are essential for cell growth and differentiation, but their trafficking by the polyamine transport system is not fully understood. Herein, the synthesis of several azido-derivatized polyamines for easy conjugation by click chemistry is described. Attachment of a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY) dye gave fluorescent polyamine probes, which were tested in cell culture. The linear probe series showed superior cellular uptake compared with that of probes in which the dye was attached to a branch on one of the central amines...
May 4, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29433851/systemic-medication-associations-with-presumed-advanced-or-uncontrolled-primary-open-angle-glaucoma
#12
Wei Zheng, Thaddeus P Dryja, Zhongyuan Wei, Dongying Song, Haijun Tian, Kristijan H Kahler, Anthony P Khawaja
PURPOSE: To identify associations between systemic medications and primary open-angle glaucoma (POAG) requiring a procedure using United States insurance claims data in a hypothesis-generating study. DESIGN: Database study. PARTICIPANTS: In total, 6130 POAG cases (defined as patients with POAG undergoing a glaucoma procedure) were matched to 30 650 controls (defined as patients undergoing cataract surgery but without a coded glaucoma diagnosis, procedure, or medication) by age, gender, and region of residence...
February 9, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29425543/-digital-ischemia-revealing-multiple-myeloma
#13
Z Khammar, M Ouazzani, B Bennani, N Oubelkacem, R Berrady
Digital ulcers generally arise in a context of microangiopathy-related focal ischemia. In women, connective tissue diseases are the main etiology, while in men the cause is often diffuse arterial disease, e.g. Leo-Buerger disease, or emboligenic heart disease. A paraneoplastic origin of digital necrosis due to ischemia is rarely reported. A 75-year-old man presented with cyanosis of the fingertips and toes that had begun one month earlier. The physical examination found pulp ulcers on the fingers and toes of both hands and feet...
February 2018: Journal de Médecine Vasculaire
https://www.readbyqxmd.com/read/29420658/comparing-residential-contamination-in-a-houston-environmental-justice-neighborhood-before-and-after-hurricane-harvey
#14
COMPARATIVE STUDY
Jennifer A Horney, Gaston A Casillas, Erin Baker, Kahler W Stone, Katie R Kirsch, Krisa Camargo, Terry L Wade, Thomas J McDonald
INTRODUCTION: Polycyclic aromatic hydrocarbons (PAHs) are complex environmental toxicants. Exposure to them has been linked to adverse health outcomes including cancer, as well as diseases of the skin, liver, and immune system. Based on an ongoing community engagement partnership with stakeholder groups and residents, we conducted a small longitudinal study to assess domestic exposure to PAHs among residents of Manchester, an environmental justice neighborhood located in the East End of Houston, TX...
2018: PloS One
https://www.readbyqxmd.com/read/29401275/primary-amebic-meningoencephalitis-associated-with-rafting-on-an-artificial-whitewater-river-case-report-and-environmental-investigation
#15
Jennifer R Cope, Jennifer Murphy, Amy Kahler, Daniel G Gorbett, Ibne Ali, Brandi Taylor, Lisa Corbitt, Shantanu Roy, Nicole Lee, Dawn Roellig, Scott Brewer, Vincent R Hill
Background: Naegleria fowleri is a thermophilic ameba found in freshwater that causes primary amebic meningoencephalitis (PAM) when it enters the nose and migrates to the brain. Patient exposure to water containing the ameba typically occurs in warm freshwater lakes and ponds during recreational water activities. In June 2016, an 18-year-old woman died of PAM after traveling to North Carolina, where she participated in rafting on an artificial whitewater river. Methods: We conducted an epidemiologic and environmental investigation to determine the water exposure that led to the death of this patient...
February 1, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29395094/robotic-assisted-surgery-in-live-donor-uterus-transplantation
#16
EDITORIAL
Mats Brännström, Pernilla Dahm-Kähler, Niclas Kvarnström
No abstract text is available yet for this article.
February 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29391397/butyrate-enhances-mitochondrial-function-during-oxidative-stress-in-cell-lines-from-boys-with-autism
#17
Shannon Rose, Sirish C Bennuri, Jakeira E Davis, Rebecca Wynne, John C Slattery, Marie Tippett, Leanna Delhey, Stephan Melnyk, Stephen G Kahler, Derrick F MacFabe, Richard E Frye
Butyrate (BT) is a ubiquitous short-chain fatty acid (SCFA) principally derived from the enteric microbiome. BT positively modulates mitochondrial function, including enhancing oxidative phosphorylation and beta-oxidation and has been proposed as a neuroprotectant. BT and other SCFAs have also been associated with autism spectrum disorders (ASD), a condition associated with mitochondrial dysfunction. We have developed a lymphoblastoid cell line (LCL) model of ASD, with a subset of LCLs demonstrating mitochondrial dysfunction (AD-A) and another subset of LCLs demonstrating normal mitochondrial function (AD-N)...
February 2, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29372905/production-biophysical-characterization-and-initial-crystallization-studies-of-the-n-and-c-terminal-domains-of-dsbd-an-essential-enzyme-in-neisseria-meningitidis
#18
Roxanne P Smith, Andrew E Whitten, Jason J Paxman, Charlene M Kahler, Martin J Scanlon, Begoña Heras
The membrane protein DsbD is a reductase that acts as an electron hub, translocating reducing equivalents from cytoplasmic thioredoxin to a number of periplasmic substrates involved in oxidative protein folding, cytochrome c maturation and oxidative stress defence. DsbD is a multi-domain protein consisting of a transmembrane domain (t-DsbD) flanked by two periplasmic domains (n-DsbD and c-DsbD). Previous studies have shown that DsbD is required for the survival of the obligate human pathogen Neisseria meningitidis...
January 1, 2018: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/29347264/statistical-mechanics-of-stochastic-growth-phenomena
#19
Oleg Alekseev, Mark Mineev-Weinstein
We develop statistical mechanics for stochastic growth processes and apply it to Laplacian growth by using its remarkable connection with a random matrix theory. The Laplacian growth equation is obtained from the variation principle and describes adiabatic (quasistatic) thermodynamic processes in the two-dimensional Dyson gas. By using Einstein's theory of thermodynamic fluctuations we consider transitional probabilities between thermodynamic states, which are in a one-to-one correspondence with simply connected domains occupied by gas...
July 2017: Physical Review. E
https://www.readbyqxmd.com/read/29336522/continued-root-maturation-despite-persistent-apical-periodontitis-of-immature-permanent-teeth-after-failed-regenerative-endodontic-therapy
#20
Louis M Lin, Sahng G Kim, Gabriela Martin, Bill Kahler
Three immature permanent teeth with pulp necrosis and apical periodontitis were treated with regenerative endodontic therapy (RET), which included root canal disinfection with sodium hypochlorite irrigation, intra-canal medication with calcium hydroxide paste, 17% EDTA rinse, induction of periapical bleeding into the canal, collagen matrix and MTA coronal seal, and composite resin restoration of access cavities. After different periods of follow-up, it was observed that continued root maturation, especially apical closure occurred despite persistent apical periodontitis of immature permanent teeth after failed RET...
January 16, 2018: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
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