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https://www.readbyqxmd.com/read/28934108/markers-of-microbial-translocation-and-immune-activation-predict-cognitive-processing-speed-in-heavy-drinking-men-living-with-hiv
#1
Mollie A Monnig, Christopher W Kahler, Patricia A Cioe, Peter M Monti, Kenneth H Mayer, David W Pantalone, Ronald A Cohen, Bharat Ramratnam
HIV infection and alcohol use disorder are associated with deficits in neurocognitive function. Emerging evidence points to pro-inflammatory perturbations of the gut-brain axis as potentially contributing to neurocognitive impairment in the context of HIV and chronic heavy alcohol use. This study examined whether plasma markers of microbial translocation (LPS) from the gastrointestinal tract and related immune activation (sCD14, EndoCAb) were associated with neurocognition in 21 men living with HIV who were virally suppressed on antiretroviral therapy...
September 21, 2017: Microorganisms
https://www.readbyqxmd.com/read/28928766/genetics-of-tinnitus-time-to-biobank-phantom-sounds
#2
Christopher R Cederroth, Anna K Kähler, Patrick F Sullivan, Jose A Lopez-Escamez
Tinnitus is a common phantom sensation resulting most often from sensory deprivation, and for which little knowledge on the molecular mechanisms exists. While the existing evidence for a genetic influence on the condition has been until now sparse and underpowered, recent data suggest that specific forms of tinnitus have a strong genetic component revealing that not all tinnitus percepts are alike, at least in how they are genetically driven. These new findings pave the way for a better understanding on how phantom sensations are molecularly driven and call for international biobanking efforts...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28875876/commercial-herbal-medicines-used-as-african-traditional-medicines-ngoma-herbal-tonic-immune-booster-interferes-with-a-rapid-urine-drug-screening-test
#3
M E Mothibe, E Osuch, C P Kahler-Venter
BACKGROUND: The prevalent use of African traditional medicine by the general public has been reported. With commercialisation and marketing, some of the herbal medicines (HMs) used are readily available over the counter, most of them promoted as immune boosters. These commercial HMs have not been taken through clinical trials and other tests that would validate their composition and safety, and other properties such as their effect on laboratory diagnostic tests. OBJECTIVE: To investigate the cross-reactivity of selected HMs with commonly tested drugs of abuse (DoA) using a qualitative rapid urinalysis assay...
August 25, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28874942/effect-of-a-no-superuser-opioid-prescription-policy-on-ed-visits-and-statewide-opioid-prescription
#4
Zachary P Kahler, Paul I Musey, Jason T Schaffer, Annelyssa N Johnson, Christian C Strachan, Charles M Shufflebarger
INTRODUCTION: The U.S. opioid epidemic has highlighted the need to identify patients at risk of opioid abuse and overdose. We initiated a novel emergency department- (ED) based interventional protocol to transition our superuser patients from the ED to an outpatient chronic pain program. The objective was to evaluate the protocol's effect on superusers' annual ED visits. Secondary outcomes included a quantitative evaluation of statewide opioid prescriptions for these patients, unique prescribers of controlled substances, and ancillary testing...
August 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28852932/bioenergetic-variation-is-related-to-autism-symptomatology
#5
Leanna Delhey, Ekim Nur Kilinc, Li Yin, John Slattery, Marie Tippett, Rebecca Wynne, Shannon Rose, Stephen Kahler, Shirish Damle, Agustin Legido, Michael J Goldenthal, Richard E Frye
Autism spectrum disorder (ASD) has been associated with mitochondrial dysfunction but few studies have examined the relationship between mitochondrial function and ASD symptoms. We measured Complex I and IV and citrate synthase activities in 76 children with ASD who were not receiving vitamin supplementation or medication. We also measured language using the Preschool Language Scales or Clinical Evaluation of Language Fundamentals, adaptive behavior using the Vineland Adaptive Behavioral Scale, social function using the Social Responsiveness Scale and behavior using Aberrant Behavior Checklist, Childhood Behavior Checklist and the Ohio Autism Clinical Impression Scale...
August 29, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28852348/lessons-and-advice-from-our-patients-a-focus-group-of-sarcoma-survivors
#6
Jill Kain, Amanda Carlson, Justin Kahler, Julianna Bemboom, Katelyn McDonald, Benjamin Miller
BACKGROUND: Sarcomas are a rare, encompassing a heterogeneous group of malignancies. Success treatment often requires a combination of surgical resection, chemotherapy, and/or radiation. These life-altering interventions can have lasting impact on function and quality-of-life. There is little known about treatment outcomes from the perspective of sarcoma patients. PURPOSE: The initial goal of this investigation was to determine the sources and categories of information patients sought at various time points in their care...
2017: Iowa Orthopaedic Journal
https://www.readbyqxmd.com/read/28828920/data-quality-in-the-swedish-quality-register-of-gynecologic-cancer-a-swedish-gynecologic-cancer-group-swegcg-study
#7
Per Rosenberg, Preben Kjølhede, Christian Staf, Maria Bjurberg, Christer Borgfeldt, Pernilla Dahm-Kähler, Kristina Hellman, Elisabet Hjerpe, Erik Holmberg, Karin Stålberg, Bengt Tholander, Elisabeth Åvall Lundqvist, Thomas Högberg
AIM: The aim of this study is to evaluate the quality of data on endometrial (EC) and ovarian, fallopian tube, peritoneal, abdominal or pelvic cancers (OC) registered in the Swedish Quality Register of Gynecologic Cancer (SQRGC). METHOD: A random sample of 500 patients was identified in the SQRGC and their medical charts were reviewed for re-abstraction of 31 selected core variables by an independent validator. The data in the SQRGC and the re-abstracted data were compared...
August 22, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28815955/the-role-of-iqsec2-in-syndromic-intellectual-disability-narrowing-the-diagnostic-odyssey
#8
Benjamin M Helm, Zoe Powis, Carlos E Prada, Olga L Casasbuenas-Alarcon, Tonya Balmakund, G B Schaefer, Stephen G Kahler, Julie Kaylor, Susan Winter, Yuri A Zarate, Samantha A Schrier Vergano
While X-linked intellectual disability (XLID) syndromes pose a diagnostic challenge for clinicians, an increasing number of recognized disorders and their genetic etiologies are providing answers for patients and their families. The availability of clinical exome sequencing is broadening the ability to identify mutations in genes previously unrecognized as causing XLID. In recent years, the IQSEC2 gene, located at Xp11.22, has emerged as the cause of multiple cases of both nonsyndromic and syndromic XLID. Herein we present a case series of six individuals (five males, one female) with intellectual disability and seizures found to have alterations in IQSEC2...
August 17, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28800182/development-and-preliminary-pilot-evaluation-of-a-brief-tablet-computer-intervention-to-motivate-tobacco-quitline-use-among-smokers-in-substance-use-treatment
#9
Richard A Brown, Jacki Hecht, Erika L Bloom, Haruka Minami, Christopher W Kahler, Ana M Abrantes, Mary E Dubreuil, Alan Gordon, Lawrence H Price, Steven J Ondersma
BACKGROUND AND OBJECTIVES: The majority of individuals in substance use disorder (SUD) treatment also smoke cigarettes; yet, the availability of smoking cessation services in SUD treatment remains limited. In this study, we developed and piloted a brief intervention for smokers in SUD treatment intended to motivate engagement in tobacco quitline treatment (TIME-TQ). METHODS: First, we interviewed 19 smokers in SUD treatment to inform the development of TIME-TQ (Phase 1)...
August 11, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/28769880/human-gut-microbiota-toward-an-ecology-of-disease
#10
REVIEW
Susannah Selber-Hnatiw, Belise Rukundo, Masoumeh Ahmadi, Hayfa Akoubi, Hend Al-Bizri, Adelekan F Aliu, Tanyi U Ambeaghen, Lilit Avetisyan, Irmak Bahar, Alexandra Baird, Fatema Begum, Hélène Ben Soussan, Virginie Blondeau-Éthier, Roxane Bordaries, Helene Bramwell, Alicia Briggs, Richard Bui, Matthew Carnevale, Marisa Chancharoen, Talia Chevassus, Jin H Choi, Karyne Coulombe, Florence Couvrette, Samantha D'Abreau, Meghan Davies, Marie-Pier Desbiens, Tamara Di Maulo, Sean-Anthony Di Paolo, Sabrina Do Ponte, Priscyla Dos Santos Ribeiro, Laure-Anne Dubuc-Kanary, Paola K Duncan, Frédérique Dupuis, Sara El-Nounou, Christina N Eyangos, Natasha K Ferguson, Nancy R Flores-Chinchilla, Tanya Fotakis, Mariam Gado Oumarou H D, Metodi Georgiev, Seyedehnazanin Ghiassy, Natalija Glibetic, Julien Grégoire Bouchard, Tazkia Hassan, Iman Huseen, Marlon-Francis Ibuna Quilatan, Tania Iozzo, Safina Islam, Dilan B Jaunky, Aniththa Jeyasegaram, Marc-André Johnston, Matthew R Kahler, Kiranpreet Kaler, Cedric Kamani, Hessam Karimian Rad, Elisavet Konidis, Filip Konieczny, Sandra Kurianowicz, Philippe Lamothe, Karina Legros, Sebastien Leroux, Jun Li, Monica E Lozano Rodriguez, Sean Luponio-Yoffe, Yara Maalouf, Jessica Mantha, Melissa McCormick, Pamela Mondragon, Thivaedee Narayana, Elizaveta Neretin, Thi T T Nguyen, Ian Niu, Romeo B Nkemazem, Martin O'Donovan, Matthew Oueis, Stevens Paquette, Nehal Patel, Emily Pecsi, Jackie Peters, Annie Pettorelli, Cassandra Poirier, Victoria R Pompa, Harshvardhan Rajen, Reginald-Olivier Ralph, Josué Rosales-Vasquez, Daria Rubinshtein, Surya Sakr, Mohammad S Sebai, Lisa Serravalle, Fily Sidibe, Ahnjana Sinnathurai, Dominique Soho, Adithi Sundarakrishnan, Veronika Svistkova, Tsolaye E Ugbeye, Megan S Vasconcelos, Michael Vincelli, Olga Voitovich, Pamela Vrabel, Lu Wang, Maryse Wasfi, Cong Y Zha, Chiara Gamberi
Composed of trillions of individual microbes, the human gut microbiota has adapted to the uniquely diverse environments found in the human intestine. Quickly responding to the variances in the ingested food, the microbiota interacts with the host via reciprocal biochemical signaling to coordinate the exchange of nutrients and proper immune function. Host and microbiota function as a unit which guards its balance against invasion by potential pathogens and which undergoes natural selection. Disturbance of the microbiota composition, or dysbiosis, is often associated with human disease, indicating that, while there seems to be no unique optimal composition of the gut microbiota, a balanced community is crucial for human health...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28763797/evaluation-of-real-world-treatment-outcomes-in-patients-with-distant-metastatic-merkel-cell-carcinoma-following-second-line-chemotherapy-in-europe
#11
Jürgen C Becker, Eva Lorenz, Selma Ugurel, Thomas K Eigentler, Felix Kiecker, Claudia Pföhler, Ivonne Kellner, Friedegund Meier, Katharina Kähler, Peter Mohr, Carola Berking, Gabriele Haas, Christoph Helwig, Dina Oksen, Dirk Schadendorf, Lisa Mahnke, Murtuza Bharmal
BACKGROUND AND AIMS: Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer; few treatments exist for patients with advanced disease. Once tumors metastasize to distant sites, patients generally receive chemotherapy, but response duration and progression-free survival (PFS) are typically short. Few studies have assessed the efficacy of second-line chemotherapy for metastatic MCC. Here, we studied outcomes in patients who received ≥ 2 lines of chemotherapy for metastatic MCC. MATERIALS AND METHODS: Patients in an MCC-specific registry diagnosed with stage IV MCC between November 1, 2004, and September 15, 2015, and treated with second-line or later chemotherapy were analyzed retrospectively...
July 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28742932/a-pilot-randomized-clinical-trial-testing-integrated-12-step-facilitation-itsf-treatment-for-adolescent-substance-use-disorder
#12
John F Kelly, Yifrah Kaminer, Christopher W Kahler, Bettina Hoeppner, Julie Yeterian, Julie V Cristello, Christine Timko
BACKGROUND AND AIMS: The integration of 12-Step philosophy and practices is common in adolescent substance use disorder (SUD) treatment programs, particularly in North America. However, although numerous experimental studies have tested 12-Step facilitation (TSF) treatments among adults, no studies have tested TSF-specific treatments for adolescents. We tested the efficacy of a novel integrated TSF. DESIGN: Explanatory, parallel-group, randomized clinical trial comparing 10 sessions of either motivational enhancement therapy/cognitive-behavioral therapy (MET/CBT; n = 30) or a novel integrated TSF (iTSF; n = 29), with follow-up assessments at 3, 6 and 9 months following treatment entry...
July 25, 2017: Addiction
https://www.readbyqxmd.com/read/28666261/chemosensitivity-directed-therapy-compared-to-dacarbazine-in-chemo-naive-advanced-metastatic-melanoma-a-multicenter-randomized-phase-3-decog-trial
#13
Selma Ugurel, Carmen Loquai, Patrick Terheyden, Dirk Schadendorf, Erika Richtig, Jochen Utikal, Ralf Gutzmer, Knuth Rass, Cord Sunderkötter, Annette Stein, Michael Fluck, Martin Kaatz, Uwe Trefzer, Katharina Kähler, Rudolf Stadler, Carola Berking, Christoph Höller, Laura Kerschke, Lutz Edler, Annette Kopp-Schneider, Jürgen C Becker
Chemotherapy still plays an important role in metastatic melanoma, particularly for patients who are not suitable or have no access to highly efficacious new therapies. Pre-therapeutic chemosensitivity testing might be useful to identify optimal chemotherapy regimens for individual patients. This multicenter randomized phase-3 trial was aimed to test for superiority of chemosensitivity-directed combination chemotherapy compared to standard dacarbazine monochemotherapy, and to demonstrate the chemosensitivity test result as prognostic in metastatic melanoma...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28659259/initial-progress-toward-development-of-a-voice-based-computer-delivered-motivational-intervention-for-heavy-drinking-college-students-an-experimental-study
#14
Christopher W Kahler, William J Lechner, James MacGlashan, Tyler B Wray, Michael L Littman
BACKGROUND: Computer-delivered interventions have been shown to be effective in reducing alcohol consumption in heavy drinking college students. However, these computer-delivered interventions rely on mouse, keyboard, or touchscreen responses for interactions between the users and the computer-delivered intervention. The principles of motivational interviewing suggest that in-person interventions may be effective, in part, because they encourage individuals to think through and speak aloud their motivations for changing a health behavior, which current computer-delivered interventions do not allow...
June 28, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28656404/-copd-an-update-of-current-management-recommendations
#15
REVIEW
Adrian Gillissen, Christian M Kähler, A Rembert Koczulla, Rüdiger Sauer
No abstract text is available yet for this article.
June 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28649188/using-video-conferencing-to-deliver-a-brief-motivational-intervention-for-alcohol-and-sex-risk-to-emergency-department-patients-a-proof-of-concept-pilot-study
#16
Mark A Celio, Nadine R Mastroleo, Graham DiGuiseppi, Nancy P Barnett, Suzanne M Colby, Christopher W Kahler, Don Operario, Brian Suffoletto, Peter M Monti
Brief motivational intervention (MI) is an efficacious approach to reduce heavy drinking and associated sexual risk behavior among Emergency Department (ED) patients, but the intensity of demands placed on ED staff makes the implementation of in-person MIs logistically challenging. This proof-of-concept pilot study examined the acceptability and logistic feasibility of using video-conferencing technology to deliver an MI targeting heavy drinking and risky sexual behavior to patients in an ED setting. Rigorous screening procedures were employed to ensure that the pilot sample represents the target portion of ED patients who would benefit from this multi-target MI...
2017: Addiction Research & Theory
https://www.readbyqxmd.com/read/28648699/prognostic-factors-and-outcomes-in-metastatic-uveal-melanoma-treated-with-programmed-cell-death-1-or-combined-pd-1-cytotoxic-t-lymphocyte-antigen-4-inhibition
#17
Markus V Heppt, Lucie Heinzerling, Katharina C Kähler, Andrea Forschner, Michael C Kirchberger, Carmen Loquai, Markus Meissner, Friedegund Meier, Patrick Terheyden, Beatrice Schell, Rudolf Herbst, Daniela Göppner, Felix Kiecker, David Rafei-Shamsabadi, Sebastian Haferkamp, Margit A Huber, Jochen Utikal, Mirjana Ziemer, Irmgard Bumeder, Christiane Pfeiffer, Susanne G Schäd, Christoph Schmid-Tannwald, Julia K Tietze, Thomas K Eigentler, Carola Berking
BACKGROUND: Uveal melanoma (UM) is an ocular malignancy with high potential for metastatic spread. In contrast to cutaneous melanoma, immunotherapy has not yet shown convincing efficacy in patients with UM. Combined immune checkpoint blockade with checkpoint programmed cell death-1 (PD-1) and checkpoint cytotoxic T-lymphocyte antigen-4 (CTLA-4) inhibition has not been systematically assessed for UM to date. PATIENTS AND METHODS: Patients with metastatic UM treated with either PD-1 inhibitor monotherapy or combined PD-1 inhibitor and ipilimumab (an anti-CTLA-4 monoclonal antibody) were included from 20 German skin cancer centres...
September 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28642923/the-influence-of-particle-size-and-curing-conditions-on-testing-mineral-trioxide-aggregate-cement
#18
William Nguyen Ha, Bill Kahler, Laurence James Walsh
Objectives: To assess the effects on curing conditions (dry versus submerged curing) and particle size on the compressive strength (CS) and flexural strength (FS) of set MTA cement. Materials and methods: Two different Portland cements were created, P1 and P2, with P1 < P2 in particle size. These were then used to create two experimental MTA products, M1 and M2, with M1 < M2 in particle size. Particle size analysis was performed according to ISO 13320. The particle size at the 90th percentile (i.e. the larger particles) was P1: 15...
December 2016: Acta Biomaterialia Odontologica Scandinavica
https://www.readbyqxmd.com/read/28642908/methodologies-for-measuring-the-setting-times-of-mineral-trioxide-aggregate-and-portland-cement-products-used-in-dentistry
#19
William Nguyen Ha, Timothy Nicholson, Bill Kahler, Laurence James Walsh
Objective The current standard used to measure setting time for Mineral Trioxide Aggregate (MTA) involves indentation testing with arbitrary weights. This study compared indentation testing against rheological measurements and assessed the influences of particle size and the inclusion of bismuth oxide on the setting time of experimental MTA and Portland cement (PC). Material and methods Two PCs (P1 and P2) of different particle sizes were produced using the same clinker. From these two PCs, two experimental MTAs (M1 and M2) were created with the addition of bismuth oxide...
December 2016: Acta Biomaterialia Odontologica Scandinavica
https://www.readbyqxmd.com/read/28616701/predictive-value-of-pd-l1-based-on-mrna-level-in-the-treatment-of-stage-iv-melanoma-with-ipilimumab
#20
C Brüggemann, M C Kirchberger, S M Goldinger, B Weide, A Konrad, M Erdmann, D Schadendorf, R S Croner, L Krähenbühl, K C Kähler, C Hafner, W Leisgang, F Kiesewetter, R Dummer, G Schuler, M Stürzl, L Heinzerling
INTRODUCTION: PD-L1 is established as a predictive marker for therapy of non-small cell lung cancer with pembrolizumab. Furthermore, PD-L1 positive melanoma has shown more favorable outcomes when treated with anti-PD1 antibodies and dacarbazine compared to PD-L1 negative melanoma. However, the role of PD-L1 expression with regard to response to checkpoint inhibition with anti-CTLA-4 is not clear, yet. In addition, the lack of standardization in the immunohistochemical assessment of PD-L1 makes the comparison of results difficult...
June 14, 2017: Journal of Cancer Research and Clinical Oncology
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