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https://www.readbyqxmd.com/read/27912819/endodontic-treatment-outcomes
#1
REVIEW
Nadia Chugal, Sanjay M Mallya, Bill Kahler, Louis M Lin
The primary goal of conventional endodontic treatment is prevention and/or elimination of apical periodontitis for both mature permanent teeth and immature teeth with an open apex. Besides these goals, the objectives of endodontic treatment of immature teeth include preservation of pulp vitality and often further root maturation. Robust criteria for outcome assessment are an essential determinant for any measure of treatment success for both mature and immature teeth.
January 2017: Dental Clinics of North America
https://www.readbyqxmd.com/read/27896421/multiple-behavioral-factors-are-associated-with-occurrence-of-large-flat-colorectal-polyps
#2
Tianzuo Zhan, Felix Hahn, Thomas Hielscher, Asmé Bilge, Jürgen Grüger, Jürgen Weers, Johannes Betge, Timo Gaiser, Georg Kähler, Matthias P Ebert, Sebastian Belle
PURPOSE: The prevalence of advanced dysplasia and synchronous lesions is particularly high in patients with large, flat colorectal polyps. However, the impact of lifestyle on the development of such polyps is poorly investigated. Hence, this study aims to identify associations between behavioral factors and the occurrence of large, flat colorectal polyps. METHODS: Behavioral factors were retrospectively analyzed in patients with large, flat polyps and control patients with at most one diminutive polyp...
November 28, 2016: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27875839/severe-metabolic-acidosis-and-hepatopathy-due-to-leukoencephalopathy-with-thalamus-and-brainstem-involvement-and-high-lactate
#3
Elizabeth A Sellars, Tonya Balmakund, Katherine Bosanko, Brandi L Nichols, Stephen G Kahler, Yuri A Zarate
Leukoencephalopathy with thalamus and brainstem involvement and high lactate (LTBL) is a recently described autosomal recessive mitochondrial disease characterized by early onset of neurological symptoms, a biphasic clinical course, and distinctive neuroimaging. Pathogenic variants in the EARS2 gene that encode for mitochondrial glutamyl-tRNA synthetase are responsible for LTBL. Here, we describe the clinical course of an infant diagnosed with an acute crisis of LTBL and severe liver disease. This article illustrates the utility of blood lactate quantification in addition to basic metabolic testing and brain imaging in a child with low tone and poor growth...
November 22, 2016: Neuropediatrics
https://www.readbyqxmd.com/read/27868389/monitoring-of-human-uterus-transplantation-with-cervical-biopsies-a-provisional-scoring-system-for-rejection
#4
J Mölne, V Broecker, J Ekberg, O Nilsson, P Dahm-Kähler, M Brännström
Until now, absolute uterine factor infertility has been the major untreatable form of female infertility. Recently, uterus transplantation has proven to be the first successful treatment for absolute uterine factor infertility, with demonstration of live births. Here, live donation uterus transplantation was performed in nine women. 163 cervical biopsies (149 protocol, 14 follow-up) were taken to detect histopathological signs of rejection. Based on experience from animal experiments, we used a three-grade scoring system to evaluate biopsies systematically...
November 21, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27844118/the-cost-of-infection-in-severe-open-tibial-fractures-treated-with-a-free-flap
#5
Ulrik Kähler Olesen, Nicolas Jones Pedersen, Henrik Eckardt, Line Lykke-Meyer, Christian Thorsten Bonde, Upender Martin Singh, Martin McNally
PURPOSE: Open tibial fractures needing soft tissue cover are challenging injuries. Infection risk is high, making treatment difficult and expensive. Delayed skin closure has been shown to increase the infection rate in several studies. We aimed at calculating the direct and indirect cost of treatment, and to determine the effect of delayed skin closure on this cost. METHODS: We reviewed all records of patients treated with a free flap in our institution for an open tibial fracture from 2002 to 2013...
November 14, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27817932/population-based-study-of-survival-for-women-with-serous-cancer-of-the-ovary-fallopian-tube-peritoneum-or-undesignated-origin-on-behalf-of-the-swedish-gynecological-cancer-group-swegcg
#6
Pernilla Dahm-Kähler, Christer Borgfeldt, Erik Holmberg, Christian Staf, Henrik Falconer, Maria Bjurberg, Preben Kjölhede, Per Rosenberg, Karin Stålberg, Thomas Högberg, Elisabeth Åvall-Lundqvist
OBJECTIVE: The aim of the study was to determine survival outcome in patients with serous cancer in the ovary, fallopian tube, peritoneum and of undesignated origin. METHODS: Nation-wide population-based study of women≥18years with histologically verified non-uterine serous cancer, included in the Swedish Quality Registry for primary cancer of the ovary, fallopian tube and peritoneum diagnosed 2009-2013. Relative survival (RS) was estimated using the Ederer II method...
November 3, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27810657/interrelationships-between-marijuana-demand-and-discounting-of-delayed-rewards-convergence-in-behavioral-economic-methods
#7
Elizabeth R Aston, Jane Metrik, Michael Amlung, Christopher W Kahler, James MacKillop
BACKGROUND: Distinct behavioral economic domains, including high perceived drug value (demand) and delay discounting (DD), have been implicated in the initiation of drug use and the progression to dependence. However, it is unclear whether frequent marijuana users conform to a "reinforcer pathology" addiction model wherein marijuana demand and DD jointly increase risk for problematic marijuana use and cannabis dependence (CD). METHODS: Participants (n=88, 34% female, 14% cannabis dependent) completed a marijuana purchase task at baseline...
December 1, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27797690/anxiety-sensitivity-and-distress-intolerance-as-predictors-of-cannabis-dependence-symptoms-problems-and-craving-the-mediating-role-of-coping-motives
#8
Samantha G Farris, Jane Metrik, Marcel O Bonn-Miller, Christopher W Kahler, Michael J Zvolensky
OBJECTIVE: The tendency to react with fear to anxiety-related sensations (anxiety sensitivity) and the inability to tolerate distressing psychological or physiological states (distress intolerance) are implicated in the comorbidity between affective psychopathology and cannabis use disorders. Emotionally vulnerable cannabis users may be particularly apt to use cannabis to cope with distress, which may both lead to and maintain its problematic use (e.g., dependence, craving). The current study tested a comprehensive model of anxiety sensitivity and distress intolerance as predictors of the number of cannabis dependence symptoms and problems, and severity of cannabis craving following deprivation from cannabis, and the mediating role of cannabis coping motives...
November 2016: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/27779624/modulation-of-mitochondrial-function-by-the-microbiome-metabolite-propionic-acid-in-autism-and-control-cell-lines
#9
R E Frye, S Rose, J Chacko, R Wynne, S C Bennuri, J C Slattery, M Tippett, L Delhey, S Melnyk, S G Kahler, D F MacFabe
Propionic acid (PPA) is a ubiquitous short-chain fatty acid, which is a major fermentation product of the enteric microbiome. PPA is a normal intermediate of metabolism and is found in foods, either naturally or as a preservative. PPA and its derivatives have been implicated in both health and disease. Whereas PPA is an energy substrate and has many proposed beneficial effects, it is also associated with human disorders involving mitochondrial dysfunction, including propionic acidemia and autism spectrum disorders (ASDs)...
October 25, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27771748/pharmacogenetics-of-stimulant-abuse-liability-association-of-cdh13-variant-with-amphetamine-response-in-a-racially-heterogeneous-sample-of-healthy-young-adults
#10
Adam M Leventhal, Matthew G Kirkpatrick, Mollie S Pester, John E McGeary, Robert M Swift, Steve Sussman, Christopher W Kahler
RATIONALE: A previous genome-wide association study (GWAS) in a predominately Caucasian sample of healthy young adults linked greater amphetamine-induced rewarding effects with the rs3784943 G allele of the cadherin 13 (CDH13; i.e., a cell adhesion molecule implicated in neuronal connectivity) gene. This association has not been subsequently examined, nor has it been studied in Asian populations, which may have greater frequencies of the risk allele. OBJECTIVE: The objective of this study was to examine the association of rs3784943 with amphetamine response in a racially heterogeneous sample (37 % Asian) of healthy young adults...
October 22, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27760448/-targeted-therapy-of-pulmonary-arterial-hypertension-recommendations-of-the-cologne-consensus-conference-2016
#11
M M Hoeper, C Apitz, E Grünig, M Halank, R Ewert, H Kaemmerer, H-J Kabitz, C Kähler, H Klose, H Leuchte, S Ulrich, K M Olsson, O Distler, S Rosenkranz, H A Ghofrani
The 2015 European Guidelines on Diagnosis and Treatment of Pulmonary Hypertension are also valid for Germany. The guidelines contain detailed recommendations for the targeted treatment of pulmonary arterial hypertension (PAH). However, the practical implementation of the European Guidelines in Germany requires the consideration of several country-specific issues and already existing novel data. This requires a detailed commentary to the guidelines, and in some aspects an update already appears necessary. In June 2016, a Consensus Conference organized by the PH working groups of the German Society of Cardiology (DGK), the German Society of Respiratory Medicine (DGP) and the German Society of Pediatric Cardiology (DGPK) was held in Cologne, Germany...
October 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27760446/-risk-stratification-and-follow-up-assessment-of-patients-with-pulmonary-arterial-hypertension-recommendations-of-the-cologne-consensus-conference-2016
#12
H H Leuchte, H Ten Freyhaus, H Gall, M Halank, M M Hoeper, H Kaemmerer, C Kähler, G Riemekasten, S Ulrich, M Schwaiblmair, R Ewert
The 2015 European Guidelines on Diagnosis and Treatment of Pulmonary Hypertension are also valid for Germany. The guidelines contain detailed information about the diagnosis of pulmonary hypertension, and furthermore provide novel recommendations for risk stratification and follow-up assessments. However, the practical implementation of the European Guidelines in Germany requires the consideration of several country-specific issues and already existing novel data. This requires a detailed commentary to the guidelines, and in some aspects an update already appears necessary...
October 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27750182/prevalence-and-correlates-of-substance-use-among-youth-living-with-hiv-in-clinical-settings
#13
Kristi E Gamarel, Larry Brown, Christopher W Kahler, M Isabel Fernandez, Douglas Bruce, Sharon Nichols
OBJECTIVES: The purpose of this study was to better understand the prevalence and correlates of substance use behaviors among HIV-infected adolescents in HIV care settings. METHODS: A cross-sectional sample of 2216 youth living with HIV (YLWH; ages 12-26) were recruited through the Adolescent Trials Network for HIV Interventions. Participants completed a one-time survey on sociodemographic factors, substance use and health behaviors. We used logistic regression models to understand the correlates of substance use outcomes...
December 1, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27747257/the-role-of-gender-affirmation-in-psychological-well-being-among-transgender-women
#14
Tiffany R Glynn, Kristi E Gamarel, Christopher W Kahler, Mariko Iwamoto, Don Operario, Tooru Nemoto
High prevalence of psychological distress, including greater depression, lower self-esteem, and suicidal ideation, has been documented across numerous samples of transgender women and has been attributed to high rates of discrimination and violence. According to the gender affirmation framework (Sevelius, 2013), access to sources of gender-affirmative support can offset such negative psychological effects of social oppression. However, critical questions remain unanswered in regards to how and which aspects of gender affirmation are related to psychological well-being...
September 2016: Psychology of Sexual Orientation and Gender Diversity
https://www.readbyqxmd.com/read/27690619/characteristics-of-intermittent-smokers-and-their-association-with-quit-intentions-in-a-sample-of-heavy-drinking-hiv-infected-men-who-have-sex-with-men
#15
Patricia A Cioe, Kristi E Gamarel, David W Pantalone, Peter M Monti, Kenneth H Mayer, Christopher W Kahler
Intermittent smokers (ITS) have increased health risks compared with non-smokers (NS). Cigarette smoking remains prevalent among men who have sex with men (MSM) and persons living with HIV (PLWH), yet most studies in PLWH do not discriminate between daily smokers (DS) and ITS. In this study, the characteristics and quit intentions of ITS and DS are compared in a sample of heavy-drinking HIV-infected MSM. Of the 185 participants enrolled, 49.2% reported having smoked cigarettes in the past month; among those, 50...
October 2, 2016: AIDS Care
https://www.readbyqxmd.com/read/27649641/pharmacologically-induced-sex-hormone-fluctuation-effects-on-resting-state-functional-connectivity-in-a-risk-model-for-depression-a-randomized-trial
#16
Patrick MacDonald Fisher, Camilla Borgsted Larsen, Vincent Beliveau, Susanne Henningsson, Anja Pinborg, Klaus Kähler Holst, Peter Steen Jensen, Claus Svarer, Hartwig Roman Siebner, Gitte Moos Knudsen, Vibe Gedsoe Frokjaer
Women are at relatively greater lifetime risk for depression than men. This elevated risk in women is partly due to heightened risk during time periods characterized by marked fluctuations in sex hormones, including postpartum and perimenopausal periods. How sex hormone fluctuations contribute to heightened risk is not fully understood but may involve intrinsic functional connectivity. We induced a biphasic ovarian sex hormone fluctuation using the gonadotropin-releasing hormone agonist (GnRHa) goserelin to determine, with a randomized placebo-controlled design, intervention effects on or GnRHa-provoked depressive symptoms associations with change in resting-state functional connectivity (rs-FC) in 58 healthy women for six seeds (amygdala, hippocampus, anterior cingulate cortex, dorsal raphe, median raphe, and posterior cingulate cortex)...
October 19, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27646697/-the-evolution-of-3d-imaging-in-orthopedic-trauma-care-german-version
#17
S R Yarboro, P H Richter, D M Kahler
Three-dimensional (3D) imaging can enhance trauma care by allowing better evaluation of bony detail and implant position compared to conventional fluoroscopy or x‑ray. Intraoperative 3D imaging further improves this evaluation by allowing any necessary revisions to be made in the operating room prior to the patient emerging from anesthesia. This revision, if necessary, better achieves the surgical goals and alleviates the stressful situation of obtaining postoperative 3D imaging, where the benefit of revision must be balanced against the cost and risk of returning to the operating room...
October 2016: Der Unfallchirurg
https://www.readbyqxmd.com/read/27636467/sound-speed-of-primordial-fluctuations-in-supergravity-inflation
#18
Alexander Hetz, Gonzalo A Palma
We study the realization of slow-roll inflation in N=1 supergravities where inflation is the result of the evolution of a single chiral field. When there is only one flat direction in field space, it is possible to derive a single-field effective field theory parametrized by the sound speed c_{s} at which curvature perturbations propagate during inflation. The value of c_{s} is determined by the rate of bend of the inflationary path resulting from the shape of the F-term potential. We show that c_{s} must respect an inequality that involves the curvature tensor of the Kähler manifold underlying supergravity, and the ratio M/H between the mass M of fluctuations ortogonal to the inflationary path, and the Hubble expansion rate H...
September 2, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27628614/a-survey-of-various-endodontic-procedures-related-to-mineral-trioxide-aggregate-usage-by-members-of-the-australian-society-of-endodontology
#19
William N Ha, Peter Duckmanton, Bill Kahler, Laurence J Walsh
This study aims to assess education on the use of mineral trioxide aggregate (MTA) and Biodentine among members of the Australian Society of Endodontology (ASE), a society of specialist endodontists (ED) and general dentists with an interest in endodontics (GD). The study also aims to compare the procedural preferences relating to perforation repair, apical barrier, root-end filling and regenerative endodontics. A structured online questionnaire was used, which sought details of the education in the use of MTA and the procedural steps involved in perforation repair, apical barrier, root-end filling and regenerative endodontics...
December 2016: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/27623415/management-of-foreign-body-removal-in-children-by-flexible-bronchoscopy
#20
Tobias Tenenbaum, Georg Kähler, Christoph Janke, Horst Schroten, Süha Demirakca
BACKGROUND: Rigid bronchoscopy remains the gold standard in many countries to remove airway foreign bodies (FBs). We aimed to analyze the feasibility of airway FB removal in children, primarily by flexible bronchoscopy through a laryngeal mask. MATERIALS AND METHODS: Between 2008 and 2013 62 children with suspected airway FB who underwent flexible bronchoscopy were analyzed in a retrospective chart review at a tertiary university hospital with respect to clinical presentation and medical management...
September 10, 2016: Journal of Bronchology & Interventional Pulmonology
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