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https://www.readbyqxmd.com/read/29336522/continued-root-maturation-despite-persistent-apical-periodontitis-of-immature-permanent-teeth-after-failed-regenerative-endodontic-therapy
#1
Louis M Lin, Sahng G Kim, Gabriela Martin, Bill Kahler
Three immature permanent teeth with pulp necrosis and apical periodontitis were treated with regenerative endodontic therapy (RET), which included root canal disinfection with sodium hypochlorite irrigation, intra-canal medication with calcium hydroxide paste, 17% EDTA rinse, induction of periapical bleeding into the canal, collagen matrix and MTA coronal seal, and composite resin restoration of access cavities. After different periods of follow-up, it was observed that continued root maturation, especially apical closure occurred despite persistent apical periodontitis of immature permanent teeth after failed RET...
January 16, 2018: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
https://www.readbyqxmd.com/read/29329940/cardiovascular-risk-reduction-in-persons-living-with-hiv-treatment-development-feasibility-and-preliminary-results
#2
Patricia A Cioe, Kate M Guthrie, Matthew S Freiberg, David M Williams, Christopher W Kahler
Persons living with HIV (PLWH) have elevated risks for cardiovascular disease (CVD). Our goal was to develop and pilot test a tailored intervention to improve CVD risk perception and the adoption of heart-healthy behaviors. In-depth qualitative interviews were conducted with 30 PLWH participants to examine learning needs and preferences. An intervention manual was developed and tested in an open pilot with eight participants. Participants were stable on antiretroviral therapy and were recruited from two urban HIV clinics in the northeastern United States...
December 5, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/29284503/bronchoscopy-versus-an-endotracheal-tube-mounted-camera-for-the-peri-interventional-visualization-of-percutaneous-dilatational-tracheostomy-a-prospective-randomized-trial-vivapdt
#3
Jörn Grensemann, Lars Eichler, Sophie Kähler, Dominik Jarczak, Marcel Simon, Hans O Pinnschmidt, Stefan Kluge
BACKGROUND: Percutaneous dilatational tracheostomy (PDT) in critically ill patients often involves bronchoscopic optical guidance. However, this procedure is not without disadvantages. Therefore, we aimed to study a recently introduced endotracheal tube-mounted camera (VivaSightTM-SL tube [VST]; ETView, Misgav, Israel) for guiding PDT. METHODS: This was a randomized controlled trial involving 46 critically ill patients who received PDT using optical guidance with a VST or with bronchoscopy...
December 29, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29281189/influence-of-hyperoxia-on-diastolic-myocardial-and-arterial-endothelial-function
#4
T Wunderlich, N Frey, W Kähler, M Lutz, P Radermacher, S Klapa, I Koch, F Tillmans, J Witte, A Koch
OBJECTIVE: Hyperoxia is known to influence cardiovascular and endothelial function, but it is unknown if there are differences between younger and older persons. The aim of this study was to monitor changes in myocardial diastolic function and flow-mediated dilatation (FMD) in younger and elderly volunteers, before and after exposure to relevant hyperbaric hyperoxia. METHODS: 51 male patients were separated into two groups for this study. Volunteers in Group 1 (n=28, mean age 26 ±6, "juniors") and Group 2 (n=23, mean age 53 ±9, "seniors") received standard HBO₂ protocol (240kPa oxygen)...
November 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29261125/rheological-characterization-as-an-alternative-method-to-indentation-for-determining-the-setting-time-of-restorative-and-endodontic-cements
#5
William N Ha, Timothy M Nicholson, Bill Kahler, Laurence J Walsh
This study explored an alternative approach using rheology to assess setting time. The following cements were tested: ProRoot® MTA (Dentsply, Tulsa, OK, USA), Biodentine® (Septodont, Saint Maur des Fosses, France), Fuji VII®, FujiVII® EP, and Fuji IX® (from GC Corporation, Tokyo, Japan), RealSeal SE™ Sealer (SybronEndo, Amersfoort, The Netherlands), AH 26® and AH Plus (both from Dentsply DeTrey, Konstanz, Germany). Freshly mixed cements were placed into a strain-controlled rheometer (1 rad·s-1 with an applied strain of 0...
December 20, 2017: Materials
https://www.readbyqxmd.com/read/29258328/skills-to-enhance-positivity-in-suicidal-adolescents-results-from-an-open-development-trial
#6
Shirley Yen, Megan L Ranney, Katherine M Tezanos, Adam Chuong, Christopher W Kahler, Joel B Solomon, Anthony Spirito
"Skills to Enhance Positivity" (STEP) is a two-part positive affect program designed to decrease recurrent suicidal behavior in adolescents hospitalized due to suicide risk. Here, we describe the initial pilot phase in which the intervention was developed and modified based on a sample of 20 adolescent participants, aged 12 to 18 years old ( Mage = 15.9, SD = 1.5). STEP consisted of an in-person phase (four sessions) and a remote delivery phase (text messaging and phone calls). The inpatient sessions focused on psychoeducation of positive affect, mindfulness meditation, gratitude, and savoring...
December 1, 2017: Behavior Modification
https://www.readbyqxmd.com/read/29232874/alkaline-material-effects-on-roots-of-teeth
#7
REVIEW
Sowmya Shetty, Sam L Kahler, Bill Kahler
The aim of this review was to identify and analyse all studies related to the effects of alkaline materials used in dentistry on roots of teeth. The first part of the review focused on mechanical property alterations of root dentine due to sodium hypochlorite (SH) used as an irrigant solution based on MeSH (Medical Subject Heading) terms from a previous study by Pascon et al in 2009. The second part reviewed literature on calcium hydroxide (CH), mineral trioxide aggregate (MTA) and other alkaline materials used as root canal dressings or filling materials...
December 10, 2017: Materials
https://www.readbyqxmd.com/read/29210893/uterus-transplantation-a-rapidly-expanding-field
#8
Mats Brännström, Pernilla Dahm Kähler, Robert Greite, Johan Mölne, César Díaz-García, Stefan G Tullius
No abstract text is available yet for this article.
November 28, 2017: Transplantation
https://www.readbyqxmd.com/read/29210603/an-unexpected-switch-in-peptide-binding-mode-from-simulation-to-substrate-specificity
#9
Ursula Kahler, Julian E Fuchs, Peter Goettig, Klaus R Liedl
A ten microsecond molecular dynamics simulation of a kallikrein-related peptidase 7 peptide complex revealed an unexpected change in binding mode. After more than two microseconds unrestrained sampling we observe a spontaneous transition of the binding pose including a 180 degree rotation around the P1 residue. Subsequently, the substrate peptide occupies the prime side region rather than the cognate non-prime side in a stable conformation. We characterize the unexpected binding mode in terms of contacts, solvent-accessible surface area, molecular interactions and energetic properties...
December 6, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29209859/spicae-aetheroleum-in-uncomplicated-acute-bronchitis-a%C3%A2-double-blind-randomised-clinical-trial
#10
Christian Kähler, Tadeusz Derezinski, Joanna Bocian-Sobkowska, Andrea Keckeis, Gabriele Zacke
BACKGROUND: The trial aimed to evaluate the efficacy and safety of Spicae aetheroleum (Spicae ae.), a phytomedicine obtained by steam distillation of the flowering tops of Lavandula latifolia, as compared to placebo in adult patients with acute bronchitis. METHODS: Patients with uncomplicated acute bronchitis (bronchitis severity score [BSS] ≥ 5 score points) were randomly assigned to treatment with Spicae ae. or placebo in a double-blind, parallel-group design...
December 5, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29206139/alkaline-materials-and-regenerative-endodontics-a-review
#11
REVIEW
Bill Kahler, Nadia Chugal, Louis M Lin
Periapical health is the primary goal of endodontic treatment in mature and immature teeth. In addition, the goals of treatment of immature teeth with arrested root development include root growth to length and maturation of the apex, as well as thickening of the canal wall. These goals are valid for immature teeth that have been subjected to trauma and dental caries or that are the result of developmental anomalies that expose the tooth to the risk of pulp necrosis and consequently result in the cessation of root maturation...
December 5, 2017: Materials
https://www.readbyqxmd.com/read/29188134/assessing-the-prevalence-of-risk-factors-for-neglected-tropical-diseases-in-brazos-county-texas
#12
Jennifer Horney, Daniel Goldberg, Tracy Hammond, Kahler Stone, Seth Smitherman
Introduction: Although more than one billion people live at risk of neglected tropical diseases (NTDs) in areas of Asia, sub-Saharan Africa, and Latin America, the degree to which they burden countries like the U.S. is unclear. Even though many NTDs such as dengue, leishmaniasis, and Chagas disease are typically not endemic to the U.S., the possibility of their emergence is noteworthy, especially in states like Texas with high levels of poverty, large immigrant populations, geographic proximity to endemic areas, and a climate amenable to the vectors for these diseases...
October 4, 2017: PLoS Currents
https://www.readbyqxmd.com/read/29180537/a-cross-sectional-study-examining-associations-between-substance-use-frequency-problematic-use-and-stis-among-youth-living-with-hiv
#13
Kristi E Gamarel, Sharon Nichols, Christopher W Kahler, Andrew O Westfall, Michelle A Lally, Craig M Wilson
OBJECTIVES: This study sought to examine the prevalence of STIs and whether substance use frequency and/or problematic use-specifically alcohol, marijuana and other drugs-was associated with having an STI diagnosis among youth living with HIV (YLWH) METHODS: A sample of 823 YLWH were recruited at 14 adolescent HIV clinics through the Adolescent Medicine Trials Network for HIV Interventions. Study staff abstracted STI data from medical records for up to 26 weeks prior to participants' completing a cross-sectional survey including the ASSIST (Alcohol, Smoking and Substance Involvement Screening Test), which measures substance use frequency and consequences...
November 27, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29130381/lymph-node-metastases-as-only-qualifier-for-stage-iv-serous-ovarian-cancer-confers-longer-survival-than-other-sites-of-distant-disease-a-swedish-gynecologic-cancer-group-swegcg-study
#14
Elisabet Hjerpe, Christian Staf, Pernilla Dahm-Kähler, Karin Stålberg, Maria Bjurberg, Erik Holmberg, Christer Borgfeldt, Bengt Tholander, Kristina Hellman, Preben Kjølhede, Thomas Högberg, Per Rosenberg, Elisabeth Åvall-Lundqvist
BACKGROUND: The International Federation of Gynecology and Obstetrics (FIGO) ovarian cancer staging system includes no sub-stage for lymph nodes (LN) as only distant disease manifestation. We explore the prognostic implication of LN as only stage IV classifier in serous ovarian cancer. METHOD: This is a nation-wide, population-based study on 551 women with serous stage IV cancers diagnosed between 2009-2014. We compare overall survival (OS) in women with LN as only distant metastatic site to those with pleural metastases only and to patients with other/multiple stage IV manifestations...
November 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29120997/waterborne-disease-outbreaks-associated-with-environmental-and-undetermined-exposures-to-water-united-states-2013-2014
#15
R Paul McClung, David M Roth, Marissa Vigar, Virginia A Roberts, Amy M Kahler, Laura A Cooley, Elizabeth D Hilborn, Timothy J Wade, Kathleen E Fullerton, Jonathan S Yoder, Vincent R Hill
Waterborne disease outbreaks in the United States are associated with a wide variety of water exposures and are reported annually to CDC on a voluntary basis by state and territorial health departments through the National Outbreak Reporting System (NORS). A majority of outbreaks arise from exposure to drinking water (1) or recreational water (2), whereas others are caused by an environmental exposure to water or an undetermined exposure to water. During 2013-2014, 15 outbreaks associated with an environmental exposure to water and 12 outbreaks with an undetermined exposure to water were reported, resulting in at least 289 cases of illness, 108 hospitalizations, and 17 deaths...
November 10, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29120680/a-clinical-evaluation-of-a-transparent-absorbent-adhesive-wound-dressing
#16
Lotta von Cramon, Marta Markowicz, Jan Nebendahl, Verena-Constanze Buchinger-Kähler, Ernst Magnus Noah, Mustafa Narwan, Anika Behrendt, Norbert Pallua, Amrei Steinhoff
The performance of a transparent absorbent adhesive wound dressing (TAAWD) was observed over 7 days in five plastic surgery clinics across Germany. The study included 47 diverse postoperative linear wounds and donor sites with dry or minimal exudate levels. Data on ease of application and removal, adhesive strength, skin compatibility, conformability to the body, visual wound inspection and parameters of wound assessment were collected and analysed. At the end of the observation period, 100% of wounds were recorded as healing with no reported complications...
November 8, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29117697/non-orthogonal-internally-contracted-multi-configurational-perturbation-theory-nicpt-dynamic-electron-correlation-for-large-compact-active-spaces
#17
Sven Kähler, Jeppe Olsen
A computational method is presented for systems that require high-level treatments of static and dynamic electron correlation but cannot be treated using conventional complete active space self-consistent field-based methods due to the required size of the active space. Our method introduces an efficient algorithm for perturbative dynamic correlation corrections for compact non-orthogonal MCSCF calculations. In the algorithm, biorthonormal expansions of orbitals and CI-wave functions are used to reduce the scaling of the performance determining step from quadratic to linear in the number of configurations...
November 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29108353/evaluation-of-real-world-treatment-outcomes-in-patients-with-distant-metastatic-merkel-cell-carcinoma-following-second-line-chemotherapy-in-europe
#18
Jürgen C Becker, Eva Lorenz, Selma Ugurel, Thomas K Eigentler, Felix Kiecker, Claudia Pföhler, Ivonne Kellner, Friedegund Meier, Katharina Kähler, Peter Mohr, Carola Berking, Gabriele Haas, Christoph Helwig, Dina Oksen, Dirk Schadendorf, Lisa Mahnke, Murtuza Bharmal
Background and aims: Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer; few treatments exist for patients with advanced disease. Once tumors metastasize to distant sites, patients generally receive chemotherapy, but response duration and progression-free survival (PFS) are typically short. Few studies have assessed the efficacy of second-line chemotherapy for metastatic MCC. Here, we studied outcomes in patients who received ≥ 2 lines of chemotherapy for metastatic MCC. Materials and methods: Patients in an MCC-specific registry diagnosed with stage IV MCC between November 1, 2004, and September 15, 2015, and treated with second-line or later chemotherapy were analyzed retrospectively...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29100289/chemosensitivity-directed-therapy-compared-to-dacarbazine-in-chemo-naive-advanced-metastatic-melanoma-a-multicenter-randomized-phase-3-decog-trial
#19
Selma Ugurel, Carmen Loquai, Patrick Terheyden, Dirk Schadendorf, Erika Richtig, Jochen Utikal, Ralf Gutzmer, Knuth Rass, Cord Sunderkötter, Annette Stein, Michael Fluck, Martin Kaatz, Uwe Trefzer, Katharina Kähler, Rudolf Stadler, Carola Berking, Christoph Höller, Laura Kerschke, Lutz Edler, Annette Kopp-Schneider, Jürgen C Becker
Chemotherapy still plays an important role in metastatic melanoma, particularly for patients who are not suitable or have no access to highly efficacious new therapies. Pre-therapeutic chemosensitivity testing might be useful to identify optimal chemotherapy regimens for individual patients. This multicenter randomized phase-3 trial was aimed to test for superiority of chemosensitivity-directed combination chemotherapy compared to standard dacarbazine monochemotherapy, and to demonstrate the chemosensitivity test result as prognostic in metastatic melanoma...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29099082/mineral-trioxide-aggregate-a-review-of-properties-and-testing-methodologies
#20
REVIEW
William N Ha, Timothy Nicholson, Bill Kahler, Laurence J Walsh
Mineral trioxide aggregate (MTA) restoratives and MTA sealers are commonly used in endodontics. Commonly referenced standards for testing of MTA are ISO 6876, 9917-1 and 10993. A PubMed search was performed relating to the relevant tests within each ISO and "mineral trioxide aggregate". MTA restoratives are typically tested with a mixture of tests from multiple standards. As the setting of MTA is dependent upon hydration, the results of various MTA restoratives and sealers are dependent upon the curing methodology...
November 2, 2017: Materials
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