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Local anaesthetics

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https://www.readbyqxmd.com/read/29911608/increased-c-fiber-response-induced-by-experimental-disc-herniation-is-associated-with-upregulation-of-fractalkine-and-its-receptor-in-nucleus-pulposus-and-dorsal-root-ganglion
#1
D P Jacobsen, A Moen, F Haugen, J Gjerstad
Aims Lumbar radicular pain following intervertebral disc herniation may be caused by a local inflammatory response induced by nucleus pulposus (NP) cells. Here in an animal model mimicking the clinical situation following disc herniation we investigated the effect of NP on the spinal nociceptive signaling and local gene expression. Methods In anaesthetized Lewis rats, extracellular single unit recordings of spinal nociceptive activity and qPCR were used to explore the effect of NP application onto the dorsal nerve roots (L3-L5)...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29910506/local-anaesthetic-injection-point-of-erector-spinae-plane-block
#2
Serkan Tulgar, Onur Balaban
No abstract text is available yet for this article.
May 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29910493/a-study-to-compare-caudal-levobupivacaine-tramadol-and-a-combination-of-both-in-paediatric-inguinal-hernia-surgeries
#3
Neelam Dogra, Rajat Dadheech, Mahipal Dhaka, Anupama Gupta
Background and Aims: Caudal block is a safe and simple method of pain relief in young children with the drawback of a short duration of analgesia which can be overcome by adding various adjuvants to the injected local anaesthetic. We compared the effects of caudal levobupivacaine, tramadol and a combination of both in paediatric patients undergoing inguinal herniotomy. Methods: A total of 78 children aged 1-7 years, planned for inguinal herniotomy were randomly allocated into three groups...
May 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29890864/effect-of-periarticular-morphine-injection-for-total-hip-arthroplasty-a-randomised-double-blind-trial
#4
Kentaro Iwakiri, Yoichi Ohta, Yukihide Minoda, Akio Kobayashi, Hiroaki Nakamura
BACKGROUND: The periarticular multimodal cocktail injection is currently commonly used to treat postoperative pain after total hip arthroplasty (THA). Despite its analgesic effect, it is frequently reported to cause nausea and vomiting, which are adverse effects of opioids. This study aimed to assess the efficacy of morphine as a component of a multimodal cocktail injection for providing postoperative analgesia and alleviating swelling in patients who underwent THA. MATERIALS AND METHODS: This was a prospective, single-centre, randomised controlled trial involving 100 patients scheduled for unilateral THA...
June 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29887292/dexmedetomidine-in-difficult-airway-management-with-a-fibre-optic-bronchoscope-in-the-awake-patient-with-klippel-feil-syndrome
#5
S Pacreu, S Martínez, E Vilà, L Moltó, J Fernández-Candil
Klippel-Feil Syndrome is a disease characterised by congenital fusion of cervical vertebra, which leads to cervical limitation and instability. In these cases, the best option is the orotracheal intubation with the fibre-optic bronchoscope with the patient awake. The advantage is that cervical movements that could lead to neurological damage are minimised. In these patients, adequate sedation, together with instillation of local anaesthetic in the pharynx and hypopharynx, is the key to reducing patient discomfort and achieving successful orotracheal intubation...
June 7, 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29887291/radiological-study-to-evaluate-the-spreading-of-two-volumes-10-vs-20ml-of-radiological-contrast-in-the-block-of-cutaneous-branches-of-intercostal-nerves-in-medial-axillary-line-brilma-in-a-porcine-experimental-model
#6
O Varela, A Melone, R López-Menchaca, R Sevilla, D Callejo, S López-Álvarez, A Román Fernández, S García, I Mantilla, M Zaballos
OBJECTIVE: Interfascial blocks of the thoracic wall are being developed as an alternative to central blocks in breast surgery. However, there are few studies that have evaluated the anatomical extension of the local anaesthetic. The objective of this study was to analyse, using fluoroscopy, the spreading of two volumes (10 vs. 20ml) of radiological contrast in the serratus-intercostal plane block in an experimental pig model. MATERIAL AND METHODS: Ten Large-White breed pigs were selected to have a bilateral ultrasound serratus-intercostal plane block performed, with the administering of 10ml and 20ml of iopamidol in the right and left hemithorax, respectively...
June 7, 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29885165/post-operative-pain-control-in-percutaneous-nephrolithotomy
#7
Zeeshan Arshad, Syed Zafar Zaidi, Anila Jamshaid, Abdul Hafeez Quresh
OBJECTIVE: To evaluate post-surgery pain relief in percutaneous nephrolithotomy cases. METHODS: The case-control study was conducted at Indus Hospital, Karachi, from July 2014 to July 2015, and comprised patients undergoing percutaneous nephrolithotomy. The patients were randomized by snose protocol into two equal groups of cases and controls. The cases were given peri-tubal local anaesthetic infiltration of 0.25% bupivacaine, while the controls were given 10ml 0...
May 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29881622/improving-the-safety-and-tolerability-of-local-anaesthetic-outpatient-transperineal-prostate-biopsies-a-pilot-study-of-the-cambridge-prostate-biopsy-camprobe-method
#8
D Thurtle, L Starling, K Leonard, T Stone, V J Gnanapragasam
Objectives: The aim of this study was to pilot the use of a bespoke device (CAMPROBE, the CAMbridge PROstate Biopsy) to enable routine outpatient free-hand local anaesthetic (LA) transperineal prostate biopsies. Materials and methods: The CAMPROBE prototype was designed and built in our institution. Men on active surveillance due prostate resampling were invited to have a CAMPROBE biopsy as an alternative to repeat transrectal ultrasound-guided prostate biopsies (TRUSBx) as part of an approved trial (NCT02375035)...
May 2018: Journal of Clinical Urology
https://www.readbyqxmd.com/read/29871567/pain-and-outcomes-of-carpal-tunnel-release-under-local-anaesthetic-with-or-without-a-tourniquet-a-randomized-controlled-trial
#9
Hafiz J Iqbal, Ashtin Doorgakant, Nader N T Rehmatullah, Ashok L Ramavath, Prasad Pidikiti, Stephen Lipscombe
We conducted a prospective randomized controlled trial to investigate carpal tunnel decompression under local anaesthesia. Carpal tunnel decompression was performed in 37 wrists using local anaesthesia and an arm tourniquet and 36 without tourniquet but with a local anaesthetic mixture containing adrenaline. Patients who underwent carpal tunnel decompression using a tourniquet experienced a significantly greater degree of pain when compared with those who did not have a tourniquet. Pain and hand function improved to a similar degree in both groups...
January 1, 2018: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/29864969/application-of-mir-223-onto-the-dorsal-nerve-roots-in-rats-induces-hypoexcitability-in-the-pain-pathways
#10
A Legfeldt, D P Jacobsen, J Gjerstad
Aims Lumbar radicular pain is often associated with increased local and systemic synthesis of inflammatory mediators. This process can be modulated by specific microRNAs (miRs). Here, in the animal model, we investigated the effect of miR-223 on the spinal nociceptive signaling and local gene expression. Methods In anaesthetized Lewis rats, extracellular single unit recordings of spinal nociceptive activity and qPCR were used to explore the effect of miR-223 application onto the dorsal nerve roots (L3-L5). Results A significant decrease in the C-fiber response was observed following application of miR-223 onto the dorsal nerve roots...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29858510/comparison-of-peripheral-nerve-blockade-characteristics-between-non-diabetic-patients-and-patients-suffering-from-diabetic-neuropathy-a-prospective-cohort-study
#11
M Baeriswyl, P Taffé, K R Kirkham, I Bathory, V Rancati, X Crevoisier, S Cherix, E Albrecht
Animal data have demonstrated increased block duration after local anaesthetic injections in diabetic rat models. Whether the same is true in humans is currently undefined. We, therefore, undertook this prospective cohort study to test the hypothesis that type-2 diabetic patients suffering from diabetic peripheral neuropathy would have increased block duration after ultrasound-guided popliteal sciatic nerve block when compared with patients without neuropathy. Thirty-three type-2 diabetic patients with neuropathy and 23 non-diabetic control patients, scheduled for fore-foot surgery, were included prospectively...
June 2, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29802933/dibucaine-in-ionic-gradient-liposomes-biophysical-toxicological-and-activity-characterisation
#12
Veronica M Couto, Maria J Prieto, Daniela E Igartúa, Daniela A Feas, Lígia N M Ribeiro, Camila M G Silva, Simone R Castro, Viviane A Guilherme, Darlene D Dantzger, Daisy Machado, Silvia Del V Alonso, Eneida de Paula
Administration of local anaesthetics (LA) is one of the most effective pain control techniques for postoperative analgesia. However, anaesthetic agents easily diffuse into the injection site, limiting the time of anaesthesia. One approach to prolong analgesia is to entrap LA in nanostructured carriers (e.g. liposomes). Here we report that using an ammonium sulphate gradient was the best strategy to improve the encapsulation (62.6%) of dibucaine (DBC) into liposomes. Light scattering and nanotracking analyses were used to characterise vesicle properties, such as, size, polydispersity, zeta potentials and number...
May 23, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29789137/serratus-intercostal-interfascial-block-as-an-opioid-saving-strategy-in-supra-umbilical-open-surgery
#13
M T Fernández Martín, S López Álvarez, M A Pérez Herrero
INTRODUCTION: The administration of local anaesthetic in the serratus-intercostal space provides adequate analgesia in non-reconstructive breast surgery. The aim of this study was to evaluate whether the blockage of the last intercostal nerves (T7-T11) can lead to opioid savings in supra-umbilical open surgery procedures. MATERIAL AND METHODS: A prospective observational study was conducted on patients undergoing open supra-umbilical surgery under general anaesthesia and with a serratus-intercostal plane block [modified Blocking the bRanches of IntercostaL nerves in the Middle Axillary line (BRILMA)] as an associated analgesic strategy...
May 19, 2018: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/29784500/utility-of-percutaneous-catheters-for-local-anaesthetics-infusion-for-postoperative-pain-control-in-lumbar-arthrodesis-a-prospective-cohort-study
#14
F J Ortega-García, I García-Del-Pino, I Auñon-Martín, A J Carrascosa-Fernández
OBJECTIVE: To evaluate whether postoperative continuous wound infiltration of levobupivacaine through two submuscular catheters connected to two elastomeric pumps after lumbar instrumented arthrodesis is more effective than intravenous patient-controlled analgesia. MATERIAL AND METHODS: An observational, prospective cohorts study was carried out. The visual analogue scale, the need for additional rescue analgesia and the onset of adverse effects were recorded. RESULTS: Pain records measured with visual analogue scale scale were significantly lower in the 48hours postoperative record at rest (p=...
May 18, 2018: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/29781504/epidural-versus-non-epidural-or-no-analgesia-for-pain-management-in-labour
#15
REVIEW
Millicent Anim-Somuah, Rebecca Md Smyth, Allan M Cyna, Anna Cuthbert
BACKGROUND: Epidural analgesia is a central nerve block technique achieved by injection of a local anaesthetic close to the nerves that transmit pain, and is widely used as a form of pain relief in labour. However, there are concerns about unintended adverse effects on the mother and infant. This is an update of an existing Cochrane Review (Epidural versus non-epidural or no analgesia in labour), last published in 2011. OBJECTIVES: To assess the effectiveness and safety of all types of epidural analgesia, including combined-spinal-epidural (CSE) on the mother and the baby, when compared with non-epidural or no pain relief during labour...
May 21, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29777717/analysis-of-the-postoperative-periarticular-environment-and-influence-on-sustained-drug-delivery-from-a-gel-formulation
#16
Darren Svirskis, Waldron Martis, Prabhat Bhusal, Manisha Sharma, Renus Stowers, Simon W Young
Regional intraarticular delivery of local anaesthetics is effective in treating postoperative pain following total knee or hip replacement. Recent research efforts have been only partially successful in achieving sustained release of the analgesic agent, in part due to limited understanding of the biological environment into which these formulations are administered. This study aimed to detail the composition and properties of postoperative periarticular fluid (PO-PAF). PO-PAF was collected from 8 patients and the composition and physicochemical properties determined...
May 16, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29777701/ropivacaine-inhibits-the-migration-of-esophageal-cancer-cells-via-sodium-channel-independent-but-prenylation-dependent-inhibition-of-rac1-jnk-paxillin-fak
#17
Yaqin Zhang, Xiaohong Peng, Qinghong Zheng
The direct anti-proliferative and pro-apoptotic effects of local anesthetics have been well documented in various cancers. However, whether local anesthetics affect cancer metastasis and their underlying molecular mechanisms are not well understood. In this work, we show that ropivacaine at the clinically relevant concentration significantly inhibits esophageal cancer cell migration. Interestingly, ropivacaine at the same concentration does not display inhibitory effects on esophageal cancer cell growth and survival...
May 16, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29771901/achilles-tenotomy-as-an-office-procedure-and-current-practising-trends-among-new-zealand-orthopaedic-surgeons
#18
Lewis Agius, Angus Wickham, Cameron Walker, Joshua Knudsen
BACKGROUND: Percutaneous Achilles tenotomy (PAT) is performed during the final phase of casting with Ponseti method. Several settings have been proposed as venues for this procedure, however it is increasingly being performed in theatre under a general anaesthetic (GA). General anaesthesia, however, is expensive and not without risks. The purpose of the present study was to compare results of outpatient releases to theatre releases, and assess current practising trends among orthopaedic surgeons...
May 18, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29770432/automated-mandatory-bolus-versus-basal-infusion-for-maintenance-of-epidural-analgesia-in-labour
#19
REVIEW
Ban Leong Sng, Yanzhi Zeng, Nurun Nisa A de Souza, Wan Ling Leong, Ting Ting Oh, Fahad Javaid Siddiqui, Pryseley N Assam, Nian-Lin R Han, Edwin Sy Chan, Alex T Sia
BACKGROUND: Childbirth may cause the most severe pain some women experience in their lifetime. Epidural analgesia is an effective form of pain relief during labour and is considered to be the reference standard. Traditionally epidural analgesia has been delivered as a continuous infusion via a catheter in the epidural space, with or without the ability for the patient to supplement the analgesia received by activating a programmable pump to deliver additional top-up doses, known as patient-controlled epidural analgesia (PCEA)...
May 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29769505/efficacy-of-0-5-hyperbaric-bupivacaine-with-dexamethasone-versus-0-5-hyperbaric-bupivacaine-alone-in-spinal-anaesthesia-for-patient-undergoing-lower-abdominal-urological-and-lower-limb-orthopedic-surgeries
#20
M M Haque, M A Aleem, F H Haque, A B Siddique, R Afrose
Spinal anaesthesia with local anaesthetics has limited duration. Different additives have been used to prolong spinal anaesthesia. The aim of this study was to determine the efficacy of adding dexamethasone to bupivacaine in spinal anaesthesia specially whether it would prolong the duration of sensory block/ surgical analgesia and post-operative analgesia/pain free period or not. This randomized, prospective, double-blind, clinical study was conducted in the Department of Anaesthesia, Analgesia and Critical Care of Combined Military Hospital, Chittagong from October 2016 to August 2017...
April 2018: Mymensingh Medical Journal: MMJ
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