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Local anaesthetics

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https://www.readbyqxmd.com/read/27909594/knowledge-of-the-research-assistants-regarding-local-anaesthetics-and-toxicity
#1
Derya Karasu, Canan Yılmaz, Şeyda Efsun Özgünay, Mürüvvet Dayıoğlu, Çağdaş Baytar, Gülsen Korfalı
OBJECTIVE: Cardiovascular system depression, respiratory arrest, coma, convulsions, loss of consciousness, muscle twitching, blurred vision, vertigo, dizziness and numbness of the tongue can be seen in local anaesthetic toxicity. Treatment includes 20% lipid solutions, airway control, symptomatic treatment for arrhythmia and convulsions. The aim of this study is to present the knowledge of research assistants, who used local anaesthetics in daily practice, regarding these medications and toxicity treatment and to raise awareness...
August 2016: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/27891626/does-trans-spinal-and-local-dc-polarization-affect-presynaptic-inhibition-and-post-activation-depression
#2
D Kaczmarek, J Ristikankare, E Jankowska
Direct current (DC) polarization has been demonstrated to alleviate the effects of various deficits in the operation of the central nervous system. However, the effects of trans-spinal DC stimulation (tsDCS) have been investigated less extensively than the effects of transcranial DC stimulation (tDCS), and their cellular mechanisms have not been elucidated. The main objectives of this study were, therefore, to extend our previous analysis of DC effects on the excitability of primary afferents and synaptic transmission by examining the effects of DC on two spinal modulatory feed-back systems, presynaptic inhibition and post-activation depression, in an anaesthetized rat preparation...
November 28, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27891579/unexpected-motor-weakness-following-quadratus-lumborum-block-for-gynaecological-laparoscopy
#3
M Wikner
Quadratus lumborum block has recently been described as an effective and long-lasting analgesic strategy for various abdominal operations, including gynaecological laparoscopy. Despite evidence that the analgesic effect is mediated by indirect paravertebral block and that local anaesthetic spreads to the lumbar paravertebral space, there have been no reports to date of lower limb motor weakness. We present a patient with unilateral hip flexion and knee extension weakness leading to unplanned overnight admission following lateral quadratus lumborum block with 20 ml levobupivacaine 0...
November 28, 2016: Anaesthesia
https://www.readbyqxmd.com/read/27885520/the-effect-of-pre-operative-topical-anaesthetic-cream-on-the-ablative-width-and-coagulative-depth-of-ablative-fractional-resurfacing-laser
#4
Preawphan Punyaratabandhu, Rungsima Wanitphakdeedecha, Penvadee Pattanaprichakul, Panitta Sitthinamsuwan, Weeranut Phothong, Sasima Eimpunth, Visnu Lohsiriwat, Woraphong Manuskiatti
Topical anaesthetic cream (TAC) is commonly used as a pre-treatment of ablative fractional resurfacing (AFR) laser. Most of anaesthetic cream contains distilled water as major component. Therefore, pre-operative TAC may interfere the photothermal reaction in the skin treated with fractional carbon-dioxide (FCO2) laser and fractional erbium-doped yttrium aluminium garnet (FEr:YAG) laser. The objective of the study was to compare the ablative width (AW) and coagulative depth (CD) of AFR laser with and without pre-treatment with TAC...
November 24, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27879965/a-therapeutic-approach-to-paediatric-oral-disorders
#5
Enrico Calcagno, Dionisio F Barattini, Roberto Servetto
The promotion of oral health in paediatrics stands as an institutional requirement in countries such as Italy where children's dental disorders still register a high incidence in spite of high levels of general health. Guidelines indicate the need to target a large age group and stress the relevance of parental education, whom paediatricians and dentists should address to. In this respect, teething is paradigmatic, due to the interactions between inflammation of the gingival mucosa, the possible associations with systemic symptoms as well as the psychological parental component...
November 23, 2016: Minerva Pediatrica
https://www.readbyqxmd.com/read/27878813/no-cases-of-perioperative-allergy-to-local-anaesthetics-in-the-danish-anaesthesia-allergy-centre
#6
A D Kvisselgaard, M Krøigaard, H F Mosbech, L H Garvey
BACKGROUND: Local anaesthetics (LA) are often suspected as possible causes of allergic reactions. The Danish Anaesthesia Allergy Centre (DAAC) is the national reference centre for investigation of perioperative allergic reactions. The purpose of this study was to investigate the incidence of IgE-mediated immediate type perioperative allergic reactions to LA. METHODS: In the period 2004-2013, a total of 409 patients (244 women/165 men; median age 49 years, range 1-86 years) were investigated in DAAC on suspicion of allergy associated with anaesthesia and surgery...
November 22, 2016: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/27872765/cardiac-arrest-after-local-anaesthetic-toxicity-in-a-paediatric-patient
#7
Liana Maria Torres de Araújo Azi, Diego Grimaldi Figueroa, Ana Amélia Souza Simas
We report a case of a paediatric patient undergoing urological procedure in which a possible inadvertent intravascular or intraosseous injection of bupivacaine with adrenaline in usual doses caused subsequent cardiac arrest, completely reversed after administration of 20% intravenous lipid emulsion. Early diagnosis of local anaesthetics toxicity and adequate cardiovascular resuscitation manoeuvres contribute to the favourable outcome.
2016: Case Reports in Anesthesiology
https://www.readbyqxmd.com/read/27860187/autophagy-activated-by-tuberin-mtor-p70s6k-suppression-is-a-protective-mechanism-against-local-anaesthetics-neurotoxicity
#8
Jingwei Xiong, Qiuyue Kong, Leyang Dai, He Ma, Xiaofei Cao, Li Liu, Zhengnian Ding
The local anaesthetics (LAs) are widely used for peripheral nerve blocks, epidural anaesthesia, spinal anaesthesia and pain management. However, exposure to LAs for long duration or at high dosage can provoke potential neuronal damages. Autophagy is an intracellular bulk degradation process for proteins and organelles. However, both the effects of LAs on autophagy in neuronal cells and the effects of autophagy on LAs neurotoxicity are not clear. To answer these questions, both lipid LAs (procaine and tetracaine) and amide LAs (bupivacaine, lidocaine and ropivacaine) were administrated to human neuroblastoma SH-SY5Y cells...
November 15, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27836523/-why-and-how-to-perform-an-ultrasound-guided-transversus-abdominis-plane-block-a-step-by-step-approach
#9
E Nohuz, B El Drayi, A Triki, K Grossmannova, B Boudier, K Koffi, M Albaut, C Dualé
Used in clinical practice as part of a multimodal analgesic regimen, the transversus abdominis plane block (TAP block) is a relative novel procedure in which local anaesthetic agents are injected into the anatomic neurofascial space between the internal oblique and the transversus abdominis muscle. It allows a significantly prolonged duration of analgesia during the early postoperative stage in abdominal surgery. This regional anesthesia technique provides analgesia to the skin, muscles of the anterior abdominal wall and parietal peritoneum in order to decrease the incision-related pain...
December 2016: Gynécologie, Obstétrique & Fertilité
https://www.readbyqxmd.com/read/27834474/minimum-local-anaesthetic-volumes-for-a-selective-saphenous-nerve-block-a-dose-finding-study
#10
Werner Ten Hoope, Markus W Hollmann, Arthur Atchabahian, Marcel Rigaud, Gino M Kerkhoffs, Philipp Lirk, Holger M Baumann
BACKGROUND: Saphenous nerve block contributes to analgesia after knee and lower leg surgery. However, literature reports a wide range of volumes of local anaesthetic being used for this block. METHODS: A non-randomized controlled trial in a single university hospital in March 2015. Eighteen healthy volunteers (ASA 1 status, aged 27-43 years; male/female ratio 11 vs. 7) were needed to determine the minimum local anaesthetic volume (MLAV) of mepivacaine 2% using the Dixon up-and-down method to achieve a selective ultrasound-guided saphenous nerve block...
November 11, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27834451/elements-of-dialysis-nursing-practice-associated-with-successful-cannulation-result-of-an-international-survey
#11
Maria Teresa Parisotto, Francesco Pelliccia, Aileen Grassmann, Daniele Marcelli
BACKGROUND/AIM: Vascular access (VA) cannulation is an essential skill for dialysis nurses: failure to correctly repeat this operation daily may result in serious complications for the patients. This study investigates if different aspects of arteriovenous fistula and graft cannulation have an effect on the development of acute access complications, which may affect the VA survival. METHODS: In April 2009 a cross-sectional survey was conducted in 171 dialysis units located in Europe, the Middle East and Africa to collect details on VA cannulation practices...
November 9, 2016: Journal of Vascular Access
https://www.readbyqxmd.com/read/27833357/the-use-of-topical-local-anaesthetic-spray-for-suturing-paediatric-intra-oral-lacerations
#12
Karl F B Payne, Punam Kalirai, Vijay Thirunavukarasu
No abstract text is available yet for this article.
December 2016: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/27833287/precise-breast-implant-placement-using-percutaneous-chest-wall-markings
#13
Janna Joethy, Bien-Keem Tan
BACKGROUND: Traditionally, pre-operative breast markings are usually made using an indelible marker. These markings are at risk of being removed by pre-operative cleaning, positional changes and parenchymal changes post-incision. We present our approach to breast surgery with rib or intercostal markings using methylene blue. METHODS: Using an indelible marker, markings are made on the breast and the inframammary crease. A blue needle (23 G) mounted on a 1 ml syringe is prepared, and aliquots of 0...
May 2016: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/27821219/effects-of-two-different-local-anaesthetic-methods-vs-no-anaesthesia-on-pain-scores-for-intratympanic-injections
#14
N Ata, O Erdur, M H Görgülü, E Yilmaz
OBJECTIVE: This study compared the pain associated with the intratympanic injection combined with various local anaesthetics vs without anaesthesia. METHODS: The study included 40 patients (aged 18-78 years) who received intratympanic steroid injections for sudden idiopathic hearing loss or tinnitus. Each patient underwent all three injection methods at one-week intervals. Patients received one of two local anaesthetics (lidocaine injection or lidocaine spray) or no anaesthesia before intratympanic injection, and used a visual analogue scale to indicate the pain level after 5 and 45 minutes...
November 8, 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27810208/retrograde-maxillary-nerve-perineural-injection-a-tomographic-and-anatomical-evaluation-of-the-infraorbital-canal-and-evaluation-of-needle-type-and-size-in-equine-cadavers
#15
S Nannarone, G Bini, M Vuerich, L Menchetti, R Arcelli, G Angeli
The aim of this study was to investigate a new approach for equine maxillary nerve blocks, which can facilitate several orofacial surgeries. Current techniques aim at the maxillary foramen and approach via the zygomatic arch, conferring the risk of injury to several delicate structures in the target area. To investigate the feasibility of a retrograde approach from the infraorbital foramen, an anatomic study of the infraorbital canal and its surrounding structures was performed on 13 cadaveric skulls using computed tomography and anatomical dissection...
November 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27805787/cerebral-haemodynamic-response-to-somatosensory-stimulation-in-near-term-fetal-sheep
#16
S Nakamura, D W Walker, F Y Wong
Functional hyperaemia induced by a localised increase in neuronal activity has been suggested to occur in the fetal brain from positive blood oxygen level-dependent (BOLD) signal recorded by functional magnetic resonance imaging (fMRI) following acoustic stimulation. To study the effect of somatosensory input on local cerebral perfusion we used Near-infrared spectroscopy (NIRS) in anaesthetized, partially exteriorized fetal sheep where the median nerve was stimulated with trains of pulses (2 ms, 3.3 Hz) for durations of 1...
November 2, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27805442/comparison-of-paravertebral-blockade-techniques-with-and-without-ultrasound-guidance-in-calves
#17
Michela Re, Javier Blanco-Murcia, Alejandra Villaescusa, Ignacio De Gaspar, Ignacio A Gómez de Segura
OBJECTIVE To compare the effectiveness of an ultrasound-guided paravertebral nerve blockade technique (UGPNB) with distal and proximal paravertebral nerve blockade techniques without ultrasound guidance (DPNB and PPNB, respectively) in calves. ANIMALS 4 calf cadavers and 7 healthy calves. PROCEDURES A suitable acoustic window was identified to facilitate access to the T13, L1, and L2 spinal nerves in cadavers and live calves. In cadavers, nerves were injected with dye under ultrasound guidance. In calves, the UGPNB, DPNB, and PPNB were performed in random order at 10-day intervals by injection of an anesthetic solution containing 2% lidocaine hydrochloride...
November 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27803961/the-effect-of-benzyl-alcohol-on-the-dielectric-structure-of-lipid-bilayers
#18
Hadeel Alobeedallah, Bruce Cornell, Hans Coster
Molecularly tethered lipid bilayer membranes were constructed on a commercially available chemically modified gold substrate. This is a new and promising product that has allowed the construction of very robust lipid bilayers. Very high resolution electrical impedance spectroscopy (EIS) was used to determine the dielectric structure of the lipid bilayers and associated interfaces. The EIS data were modelled in terms of the dielectric substructure using purpose developed software. The hydrophobic region, where the lipid tails are located, was revealed by the EIS in the frequency range of (1-100) Hz and its thickness was calculated from the capacitance of this region and found to be approximately 3-4 nm...
December 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27798453/patient-completed-preoperative-web-based-anaesthetic-assessment-questionnaire-electronic-personal-assessment-questionnaire-preoperative-development-and-validation
#19
Iain M Goodhart, John Andrzejowski, Georgina Jones, Mireille Berthoud, Andy Dennis, Gary Mills, Stephen Radley
BACKGROUND: Worldwide, guidelines support the routine use of anaesthetic preoperative assessment (POA), a process that is frequently supported by pro formas and unvalidated questionnaires. Electronic questionnaires can provide reliable data. A local initiative has seen the development of a computerised electronic Personal Assessment Questionnaire (ePAQ). OBJECTIVE: To develop and validate a novel electronic instrument for POA. DESIGN: The content and face validity were evaluated in 30 patients...
October 27, 2016: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/27798452/double-injection-technique-assisted-by-a-nerve-stimulator-for-ultrasound-guided-supraclavicular-brachial-plexus-block-results-in-better-distal-sensory-motor-block-a-randomised-controlled-trial
#20
Quehua Luo, Weifeng Yao, HaiHua Shu, Ming Zhong
BACKGROUND: To evaluate the efficacy of a nerve stimulator when used with ultrasound-guided double injection in supraclavicular brachial plexus block. OBJECTIVES: We hypothesised that targeting the inferior trunk of the plexus guided by a nerve stimulator would obtain a higher success rate of ulnar nerve blockade than the traditional double-injection technique. DESIGN: A blinded randomised controlled study. SETTING: Conducted at the University Hospital from October 2015 to January 2016...
October 27, 2016: European Journal of Anaesthesiology
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