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Local anaesthetics

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https://www.readbyqxmd.com/read/29231159/facet-joint-injections-for-non-specific-low-back-pain-a-feasibility-rct
#1
Saowarat Snidvongs, Rod S Taylor, Alia Ahmad, Simon Thomson, Manohar Sharma, Angela Farr, Deborah Fitzsimmons, Stephanie Poulton, Vivek Mehta, Richard Langford
BACKGROUND: Pain of lumbar facet-joint origin is a common cause of low back pain in adults and may lead to chronic pain and disability, with associated health and socioeconomic implications. The socioeconomic burden includes an inability to return to work resulting in loss of productivity in addition to direct and indirect health-care utilisation costs. Lumbar facet-joints are paired synovial joints between the superior and inferior articular processes of consecutive lumbar vertebrae and between the fifth lumbar vertebra and the sacrum...
December 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29229069/the-use-of-an-iced-cotton-bud-as-an-effective-pre-cooling-method-for-palatal-anaesthesia-a-technical-note
#2
Nadeena Sri Swarnagupta Jayasuriya, Indika Danuka Weerapperuma, Malagoda Gamage Chathura Kanchana Amarasinghe
The palatal injection of anaesthesia is more painful for the patient when compared to other sites of the oral cavity. Pre-cooling (cyro anaesthesia) is a well-known method practiced to reduce pain, with the use of ice or refrigerant spray on the affected site. The already known methods of ice application to the palatal site have few practical drawbacks. Therefore, this technical note highlights the use of an iced cotton bud as a novel way of providing effective pre-cooling for palatal anaesthesia. Commercially available cotton buds were dipped in clean water and then placed in the freezer...
December 2017: Singapore Dental Journal
https://www.readbyqxmd.com/read/29225780/the-decision-to-delivery-interval-in-emergency-caesarean-sections-impact-of-anaesthetic-technique-and-work-shift
#3
Anette Hein, David Thalen, Ylva Eriksson, Jan G Jakobsson
Background: One important task of the emergency anaesthesia service is to provide rapid, safe and effective anaesthesia for emergency caesarean sections (ECS). A Decision to Delivery Interval (DDI) <30 minutes for ECS is a quality indicator for this service. The aim of this study was to assess the DDI and the impact of chosen anaesthetic technique (general anaesthesia (GA), spinal anaesthesia (SPA) with opioid supplementation, or "top-up" of labour epidural analgesia (tEDA) with local anaesthesia and fentanyl mixture) and work shift for ECS at Danderyds Hospital, Sweden...
2017: F1000Research
https://www.readbyqxmd.com/read/29223560/the-relationship-between-intestinal-and-oral-mucosa-microcirculation-in-anaesthetized-horses
#4
Klaus Hopster, Stephan Neudeck, Liza Wittenberg-Voges, Sabine Br Kästner
OBJECTIVE: To compare alteration in intestinal blood flow in anaesthetized horses with changes in oral mucosa blood flow. STUDY DESIGN: Prospective, randomized clinical study. ANIMALS: Eight warmblood horses. METHODS: After induction with guaifenesin and ketamine, anaesthesia was maintained with isoflurane at 1.5 vol% in oxygen. The tissue blood flow was measured using laser Doppler flowmetry at the jejunum, colon, rectal mucosa, oesophageal mucosa and the oral mucosa...
August 18, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29218285/efficacy-of-digital-anesthesia-comparison-of-two-techniques
#5
Muhammad Ahmad
BACKGROUND: Digital nerve block is commonly performed by care providers in medical fields. This study compares the blocks in terms of effectiveness of anesthesia and pain. METHODS: Patients were divided into two groups. First group underwent digital block whereas 2nd group had transmetacarpal digital block. The subcutaneous ring block was performed by two injections of 3 ml of 2% lignocaine in a 3 ml syringe with a 26G needle at the level of phalangeal/palmer crease...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29207250/a-survey-of-dog-and-cat-anaesthesia-in-a-sample-of-veterinary-practices-in-new-zealand
#6
H Sano, K Barker, T Odom, K Lewis, P Giordano, V Walsh, J P Chambers
AIMS: To survey current anaesthesia practices for dogs and cats in small and mixed animal practices in New Zealand in order to improve anaesthesia education. METHODS: A questionnaire was sent to 440 small and mixed animal practices, including questions regarding the type of practice, preanaesthetic examination, anaesthetic drugs and management, anaesthetic machines, monitoring and topics of interest for continuing professional development. RESULTS: Responses were obtained from 113/440 (26%) practices, with 78 (69%) respondents from small and 35 (31%) from mixed animal practices...
December 5, 2017: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/29205140/autologous-fat-transplantation-for-secondary-breast-reconstruction-our-experience
#7
F Simonacci, M P Grieco, N Bertozzi, E Raposio
BACKGROUND: Autologous fat transplantation is used after breast reconstruction to improve the breast profile. There are a variety of different methods used for fat harvesting, preparation, and reinjection. This study describes the specific techniques we used in this series of autologous fat transplantations in breast reconstruction patients and reports their outcomes compared with other studies in the literature. PATIENTS AND METHODS: At the University Hospital of Parma between May 2012 and December 2016, we performed 53 autologous fat transplantations for secondary breast reconstruction patients with an average age of 49 years (range: 34-65 y)...
May 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/29199070/anaesthetic-efficacy-of-4-articaine-compared-with-2-mepivacaine-a-randomized-double-blind-crossover-clinical-trial
#8
M C Bortoluzzi, P de Camargo Smolarek, R Cecato, M T Pochapski, A C R Chibinski
The aim of this study was to evaluate the clinical efficacy of 4% articaine (Ar4) compared to 2% mepivacaine (Me2), both in combination with 1:100,000 epinephrine, in a unique soft tissue model. This was a randomized, double-blind, crossover clinical trial. The anaesthetic was applied to the lower lip using a computerized local delivery system. The following were evaluated: blood flow, thermal sensation, pressure and proprioception, extent of anaesthesia, gradual elimination, and the final duration of the effect of the anaesthesia...
November 30, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29196683/preferential-selection-of-arginine-at-the-lipid-water-interface-of-trpv1-during-vertebrate-evolution-correlates-with-its-snorkeling-behaviour-and-cholesterol-interaction
#9
Somdatta Saha, Arijit Ghosh, Nikhil Tiwari, Ashutosh Kumar, Abhishek Kumar, Chandan Goswami
TRPV1 is a thermo-sensitive ion channel involved in neurosensory and other physiological functions. The trans-membrane helices of TRPV1 undergo quick and complex conformational changes governed by thermodynamic parameters and membrane components leading to channel opening. However, the molecular mechanisms underlying such events are poorly understood. Here we analysed the molecular evolution of TRPV1 at the lipid-water-interface region (LWI), typically defined as a layer of 6 Å thickness on each side of the membrane with less availability of free water...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29182798/pharmacological-interventions-for-pain-relief-during-orthodontic-treatment
#10
REVIEW
Aoife B Monk, Jayne E Harrison, Helen V Worthington, Annabel Teague
BACKGROUND: Pain is a common side effect of orthodontic treatment. It increases in proportion to the amount of force applied to the teeth, and the type of orthodontic appliance used can affect the intensity of the pain. Pain during orthodontic treatment has been shown to be the most common reason for people wanting to discontinue treatment, and has been ranked as the worst aspect of treatment. Although pharmacological methods of pain relief have been investigated, there remains some uncertainty among orthodontists about which painkillers are most suitable and whether pre-emptive analgesia is beneficial...
November 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29182384/efficacy-of-a-rectal-spacer-with-prostate-sabr-first-uk-experience
#11
Raymond B King, Sarah Os Osman, Ciaran Fairmichael, Denise M Irvine, Ciara A Lyons, Ananth Ravi, Joe M O'Sullivan, Alan R Hounsell, Darren M Mitchell, Conor K McGarry, Suneil Jain
OBJECTIVE: This study assessed the use of implanted hydrogel rectal spacers for SABR-VMAT patients, investigating practicality, dosimetric impact, normal tissue complication probability (NTCP) and early toxicity. METHODS: Data from the first 6 patients treated within a prostate SABR and rectal spacer trial were examined to determine spacer insertion tolerability, resultant changes in treatment planning and dosimetry and early toxicity effects. CT scans acquired prior to spacer insertion were used to generate SABR plans which were compared to post-insertion CT plans...
November 28, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29178281/abdominal-girth-and-dorso-sacral-distance-can-be-used-to-estimate-lumbosacral-cerebral-fluid-volume
#12
Q H Zhou, C Shen, G Chen
BACKGROUND: Patients' abdominal girth and vertebral column length are highly correlated with the spread of local anaesthetics after spinal anaesthesia. Lumbosacral cerebrospinal fluid volume is the primary determinant for spinal spread. Thus, we attempted to verify the hypothesis that abdominal girth and dorso-sacral distance are correlated with lumbosacral cerebrospinal fluid volume. METHODS: Forty-five healthy volunteers were enrolled in this study to measure lumbosacral cerebrospinal fluid volume using magnetic resonance imaging...
November 27, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29177072/efficacy-of-platelet-rich-plasma-injections-for-symptomatic-tendinopathy-systematic-review-and-meta-analysis-of-randomised-injection-controlled-trials
#13
Larry E Miller, William R Parrish, Breana Roides, Samir Bhattacharyya
Aim: To determine the efficacy of platelet-rich plasma (PRP) injections for symptomatic tendinopathy. Design: Systematic review of randomised, injection-controlled trials with meta-analysis. Data sources: Systematic searches of MEDLINE and EMBASE, supplemented by manual searches. Eligibility criteria for selecting studies: Randomised controlled trials with 3 months minimum follow-up that evaluated pain reduction with PRP versus control (saline, local anaesthetic, corticosteroid) injections in patients with symptomatic tendinopathy...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29172328/surgical-emphysema-a-rare-complication-of-a-simple-surgical-dental-extraction-without-the-use-of-an-air-driven-rotor
#14
Keegan Gowans, Muneer Patel, Khari Lewis
Surgical emphysema is a rare complication of dental extractions, often associated with the use of high-speed air rotors. This report describes a case of extensive surgical emphysema following a simple surgical extraction of a LL6 under local anaesthetic. There was no use of air-driven handpieces during the procedure. The patient developed extensive surgical emphysema bi-laterally in both cervical neck and facial planes. After prophylactic antibiotics with careful monitoring in a secondary care setting, the patient made a full unremarkable recovery...
March 2017: Dental Update
https://www.readbyqxmd.com/read/29170283/local-anaesthetics-combined-with-vasoconstrictors-in-patients-with-cardiovascular-disease-undergoing-dental-procedures-systematic-review-and-meta-analysis-protocol
#15
Caio Chaves Guimaraes, Rogério Heládio Lopes Motta, Cristiane de Cássia Bergamaschi, Jimmy de Oliveira Araújo, Natalia Karol de Andrade, Mabel Fernandes Figueiró, Juliana Cama Ramacciato, Luciane Cruz Lopes
INTRODUCTION: The use of vasoconstrictors combined with local anaesthetics (LAs) in dentistry for patients with cardiovascular disease (CVD) is still controversial in the scientific literature. It raises concerns regarding the possibility of transient episodes, triggering negative cardiovascular outcomes. METHOD/DESIGN: Trials eligible for our systematic review will enrol patients with CVD who have undergone dental treatments carried out with the use of LAs by comparing two arms: LAs with vasoconstrictors and LAs without vasoconstrictors...
November 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29164294/a-novel-technique-of-paravertebral-thoracic-and-preperitoneal-analgesia-enhances-early-recovery-after-oesophagectomy
#16
Stephanie Phillips, Jasmina Dedic-Hagan, d'Arcy Ferris Baxter, H Van der Wall, G L Falk
BACKGROUND: Excellent analgesia following oesophagectomy facilitates patient comfort, early extubation, physiotherapy and mobilisation, reduces post-operative complications and should enhance recovery. Thoracic epidural analgesia (TEA), the gold standard analgesic regimen for this procedure, is often associated with systemic hypotension treated with inotropes or fluid. This may compromise enhanced recovery and be complicated by anastomotic ischaemia or tissue oedema. METHODS: We report a novel analgesic regimen to reduce post-operative inotrope usage...
November 21, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29162621/needle-use-declarations-at-the-olympic-games-rio-2016
#17
Molly Allen, Mark Campbell Stuart, Hannah Gribble, Richard Budgett, Andrew Pipe
AIM: We report on the results of the 'IOC Needle Policy' applied during the course of the Games of the XXXI Summer Olympiad in Rio de Janeiro, Brazil. The policy was intended to empower physicians to ensure appropriate clinical use of needles within team medical environments, enhance the safety of those responsible for housekeeping services and others in the Olympic environment, and permit documentation of such procedures as an adjunct to the doping control programme. Any needle use required the submission of an 'Injection Declaration Form' to IOC medical officials...
November 21, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29161394/managing-anaesthetic-provision-for-global-disasters
#18
R M Craven
The numbers of people affected by large-scale disasters has increased in recent decades. Disasters produce a huge burden of surgical morbidity at a time when the affected country is least able to respond. For this reason an international disaster response is often required. For many years this disaster response was not coordinated. The response consisted of what was available not what was needed and standards of care varied widely producing a healthcare lottery for the affected population. In recent years the World Health organisation has initiated the Emergency Medical Team programme to coordinate the response to disasters and set minimum standards for responding teams...
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29153101/local-anaesthetics-more-than-meets-the-eye
#19
EDITORIAL
Michèle Dumoulin, Maarten Oosterlinck
No abstract text is available yet for this article.
October 2017: Veterinary Journal
https://www.readbyqxmd.com/read/29152410/ultrasound-triggered-local-anaesthesia
#20
Alina Y Rwei, Juan L Paris, Bruce Wang, Weiping Wang, Christopher D Axon, María Vallet-Regí, Robert Langer, Daniel S Kohane
On-demand relief of local pain would allow patients to control the timing, intensity and duration of nerve block in a safe and non-invasive manner. Ultrasound would be a suitable trigger for such a system, as it is in common clinical use and can penetrate deeply into the body. Here, we demonstrate that ultrasound-triggered delivery of an anaesthetic from liposomes allows the timing, intensity and duration of nerve block to be controlled by ultrasound parameters. On insonation, the encapsulated sonosensitizer protoporphyrin IX produces reactive oxygen species that react with the liposomal membrane, leading to the release of the potent local anaesthetic tetrodotoxin...
2017: Nature Biomedical Engineering
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