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https://www.readbyqxmd.com/read/29244990/clinical-and-epidemiological-profile-of-breast-cancer-in-mexico-results-of-the-seguro-popular
#1
Nancy Reynoso-Noverón, Cynthia Villarreal-Garza, Enrique Soto-Perez-de-Celis, Claudia Arce-Salinas, Juan Matus-Santos, María Teresa Ramírez-Ugalde, Alberto Alvarado-Miranda, Paula Cabrera-Galeana, Abelardo Meneses-García, Fernando Lara-Medina, Enrique Bargalló-Rocha, Alejandro Mohar
Purpose One half of the Mexican population lacks comprehensive health care coverage. In 2003, a reform to the General Health Law was approved that led to the creation of the System of Social Protection in Health and made universal health coverage mandatory. The main innovation of this reform was Seguro Popular, which provided coverage for breast cancer. Here we report the outcomes of women with breast cancer treated at a cancer center in Mexico under Seguro Popular. Materials and Methods This was a retrospective cohort study that included all patients with breast cancer treated in the Instituto Nacional de Cancerología in Mexico City between January 2007 and December 2013 with Seguro Popular coverage...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244989/global-use-of-traditional-and-complementary-medicine-in-childhood-cancer-a-systematic-review
#2
Caroline Diorio, Catherine G Lam, Elena J Ladas, Festus Njuguna, Glenn M Afungchwi, Katherine Taromina, Stacey Marjerrison
Purpose Traditional and complementary medicine (T&CM) strategies are commonly used in pediatric oncology. Patterns may vary based on country income. We systematically reviewed published studies describing T&CM use among pediatric oncology patients in low-income countries (LIC/LMIC), middle-income countries (UMIC), and high-income countries (HIC). Objectives included describing estimated prevalence of use, reasons for use, perceived effectiveness, modalities used, rates of disclosure, and reporting of delayed or abandoned treatment...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244988/chemotherapy-use-at-the-end-of-life-in-uganda
#3
Daniel Low, Emily C Merkel, Manoj Menon, Gary H Lyman, Henry Ddungu, Elizabeth Namukwaya, Mhoira Leng, Corey Casper
Purpose Avoiding chemotherapy during the last 30 days of life has become a goal of cancer care in the United States and Europe, yet end-of-life chemotherapy administration remains a common practice worldwide. The purpose of this study was to determine the frequency of and factors predicting end-of-life chemotherapy administration in Uganda. Methods Retrospective chart review and surveys and interviews of providers were performed at the Uganda Cancer Institute (UCI), the only comprehensive cancer center in the area, which serves a catchment area of greater than 100 million people...
December 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244270/vaginal-cuff-recurrence-after-radical-cystectomy-an-under-studied-site-of-bladder-cancer-relapse
#4
Fabio Zattoni, Alessandro Morlacco, Avinash Nehra, Igor Frank, Stephen A Boorjian, Prabin Thapa, R Jeffrey Karnes
INTRODUCTION: Vaginal cuff recurrence of tumor following radical cystectomy is a rare site of disease recurrence, however it has never been specifically studied. The aim of the study is to evaluate incidence, risk factors, and long-term oncologic outcomes of vaginal cuff recurrence in a cohort of female patients treated with radical cystectomy for invasive urothelial carcinoma of the bladder. MATERIALS AND METHODS: From 1985 to 2012, a prospectively maintained institutional bladder cancer registry was queried for vaginal cuff recurrence post radical cystectomy...
December 18, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29243774/clinical-significance-of-long-non-coding-rna-ewsat1-as-a-novel-prognostic-biomarker-in-osteosarcoma
#5
G-Y Zhang, J-F Zhang, X-M Hu, Z-P Luo, Y-Z Ma
OBJECTIVE: Long non-coding RNA EWSAT1 (EWSAT1) has been identified as a tumor promoter in several tumors, but its prognostic values in osteosarcoma have not been reported. The purpose of this study was to explore the association between EWSAT1 expression and prognosis of osteosarcoma patients. PATIENTS AND METHODS: EWSAT1 levels were examined in 176 osteosarcoma tissues and matched normal bone tissues by qRT-PCR analysis. The associations of EWSAT1 expression with clinicopathologic variables were analyzed...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29243413/clinical-response-to-apatinib-monotherapy-in-advanced-non-small-cell-lung-cancer
#6
Jianping Xu, Xiaoyan Liu, Sheng Yang, Xiangru Zhang, Yuankai Shi
AIM: Apatinib, an oral tyrosine kinase inhibitor mainly targeting VEGFR-2, exerts both antiangiogenesis and antiproliferation effects. Apatinib shows clinical benefit in advanced non-small cell lung cancer (NSCLC) at an initial dose of 750 mg qd. We further assessed the efficacy and safety of apatinib at a more frequently used dose of 500 mg qd. The preliminary clinical outcome of apatinib in patients with brain metastases was also reported. METHODS: We retrospectively reviewed the clinical data of 25 patients who received apatinib between August 2015 and May 2016...
December 15, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29242280/results-of-fertility-sparing-surgery-for-expansile-and-infiltrative-mucinous-ovarian-cancers
#7
Sebastien Gouy, Marine Saidani, Amandine Maulard, Slim Bach-Hamba, Enrica Bentivegna, Alexandra Leary, Patricia Pautier, Mojgan Devouassoux-Shisheboran, Catherine Genestie, Philippe Morice
BACKGROUND: No series had been reported focusing on the results of fertility-sparing surgery in stage I mucinous ovarian cancers according to histotype (infiltrative vs. expansile). Investigating such outcomes was the aim of the present study. MATERIALS AND METHODS: The present study was a retrospective analysis of patients treated conservatively with preservation of the uterus and contralateral ovary from 1976 to 2016. The pathology of the tumors was reviewed by two expert pathologists according to the 2014 World Health Organization (WHO) classification criteria...
December 14, 2017: Oncologist
https://www.readbyqxmd.com/read/29241970/identification-of-a-folate-receptor-targeted-near-infrared-molecular-contrast-agent-to-localize-pulmonary-adenocarcinomas
#8
Jarrod D Predina, Andrew D Newton, Courtney Connolly, Ashley Dunbar, Michael Baldassari, Charuhas Deshpande, Edward Cantu, Jason Stadanlick, Sumith A Kularatne, Philip S Low, Sunil Singhal
Non-small cell lung cancer (NSCLC) is the number one cancer killer in the United States. Despite attempted curative surgical resection, nearly 40% of patients succumb to recurrent disease. High recurrence rates may be partially explained by data suggesting that 20% of NSCLC patients harbor synchronous disease that is missed during resection. In this report, we describe the use of a novel folate receptor-targeted near-infrared contrast agent (OTL38) to improve the intraoperative localization of NSCLC during pulmonary resection...
October 26, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29241089/association-of-psychosis-with-antiphospholipid-antibody-syndrome-a-systematic-review-of-clinical-studies
#9
Asma Hallab, Sadiq Naveed, Ahmed Altibi, Mariam Abdelkhalek, Huyen Thi Ngo, Thao Phuong Le, Kenji Hirayama, Nguyen Tien Huy
OBJECTIVE: In this systematic review, we reviewed the association between Antiphospholipid antibody syndrome (APS) and psychosis and focused on the prevalence, clinical presentation, immunologic and neurological workup, treatment options, and clinical outcomes. METHODOLOGY: We performed this systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)'s guidelines. We searched eight databases for potential articles and manually searched references and relevant articles of included studies...
November 16, 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29240884/a-proposal-for-a-comprehensive-risk-scoring-system-for-predicting-postoperative-complications-in-octogenarian-patients-with-medically-operable-lung-cancer-jacs1303
#10
Hisashi Saji, Takahiko Ueno, Hiroshige Nakamura, Norihito Okumura, Masanori Tsuchida, Makoto Sonobe, Takuro Miyazaki, Keiju Aokage, Masayuki Nakao, Tomohiro Haruki, Hiroyuki Ito, Kazuhiko Kataoka, Kazunori Okabe, Kenji Tomizawa, Kentaro Yoshimoto, Hirotoshi Horio, Kenji Sugio, Yasuhisa Ode, Motoshi Takao, Morihito Okada, Masayuki Chida
OBJECTIVES: Although some retrospective studies have reported clinicopathological scoring systems for predicting postoperative complications and survival outcomes for elderly lung cancer patients, optimized scoring systems remain controversial. METHODS: The Japanese Association for Chest Surgery (JACS) conducted a nationwide multicentre prospective cohort and enrolled a total of 1019 octogenarians with medically operable lung cancer. Details of the clinical factors, comorbidities and comprehensive geriatric assessment were recorded for 895 patients to develop a comprehensive risk scoring (RS) system capable of predicting severe complications...
December 11, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29240580/prognostic-significance-of-periadnexal-extension-in-cutaneous-melanoma-and-its-implications-for-pathologic-reporting-and-staging
#11
Tristan J Dodds, Serigne Lo, Louise Jackett, Omgo Nieweg, John F Thompson, Richard A Scolyer
Tumor thickness is the strongest predictor of outcome for clinically localized melanoma. Therefore, accurate assessment is critical for appropriate staging, reliable estimation of prognosis, and management. When melanoma extends alongside skin adnexal structures more deeply than the main tumor mass (periadnexal extension), it is currently unknown whether the prognosis is more accurately reflected by the deepest point of periadnexal tumor extension or the main tumor mass. This study sought to address this question...
December 7, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29239571/spatial-temporal-analysis-of-prostate-cancer-incidence-from-the-pennsylvania-cancer-registry-2000-2011
#12
Ming Wang, Stephen A Matthews, Khaled Iskandarani, Yimei Li, Zheng Li, Vernon M Chinchilli, Lijun Zhang
Prostate cancer is the most common cancer diagnosed among males, and the incidence in Pennsylvania, USA is considerably higher than nationally. Knowledge of regional differences and time trends in prostate cancer incidence may contribute to a better understanding of aetiologic factors and racial disparities in outcomes, and to improvements in preventive intervention and screening efforts. We used Pennsylvania Cancer Registry data on reported prostate cancer diagnoses between 2000 and 2011 to study the regional distribution and temporal trends of prostate cancer incidence in both Pennsylvania White males and Philadelphia metropolitan area Black males...
November 28, 2017: Geospatial Health
https://www.readbyqxmd.com/read/29239214/brainstem-metastases-treated-with-gamma-knife-stereotactic-radiosurgery-the-indiana-university-health-experience
#13
Ajay Patel, Homan Mohammadi, Tuo Dong, Kevin Ren-Yeh Shiue, Douglas Frye, Yi Le, Shaheryar Ansari, Gordon A Watson, James C Miller, Tim Lautenschlaeger
Brainstem metastases offer a unique challenge in cancer treatment, yet stereotactic radiosurgery (SRS) has proven to be an effective modality in treating these tumors. This report discusses the clinical outcomes of patients with brainstem metastases treated at Indiana University with Gamma Knife (GK) radiosurgery from 2008 to 2016. 19 brainstem metastases from 14 patients who had follow-up brain imaging were identified. Median tumor volume was 0.04 cc (range: 0.01-2.0 cc). Median prescribed dose was 17...
December 14, 2017: CNS Oncology
https://www.readbyqxmd.com/read/29239060/prevalence-and-predictors-of-depression-pain-and-fatigue-in-older-versus-younger-adult-cancer-survivors
#14
Lisa A Bevilacqua, Deirdre Dulak, Elizabeth Schofield, Tatiana D Starr, Christian J Nelson, Andrew J Roth, Jimmie C Holland, Yesne Alici
BACKGROUND: As the number of older adults in the United States continues to grow, there will be increasing demands on health care providers to address the needs of this population. Cancer is of particular importance, with over half of all cancer survivors over age 65. In addition, depression, pain, and fatigue are concerns for older adults with cancer and have been linked to poorer physical outcomes. METHODS: For this retrospective chart review, 1012 eligible participants were identified via a query of the Electronic Medical Record for all patients referred to one of four Survivorship Clinics at Memorial Sloan Kettering Cancer Center...
December 14, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/29239009/falls-in-older-adults-with-multiple-myeloma
#15
Tanya M Wildes, Mark A Fiala
To examine the prevalence of falls, factors associated with falls and the relationship between falls and survival in older adults with multiple myeloma METHODS: In an analysis of the Surveillance, Epidemiology and End Results (SEER)-Medicare Health Outcomes Survey (MHOS) linked database, we examined 405 older adults with MM and 513 matched non-cancer controls. The primary outcome was self-reported within the past 12 months. Age, race, gender, symptoms and comorbidities were self-reported in the MHOS. Survival was calculated from SEER data RESULTS: Of the patients with MM, 171 were within 1 year of diagnosis (cohort 1) and 234 were ≥1 year post-diagnosis (cohort 2)...
December 14, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/29238608/study-protocol-for-enhancing-parenting-in-cancer-epic-development-and-evaluation-of-a-brief-psycho-educational-intervention-to-support-parents-with-cancer-who-have-young-children
#16
Lesley Stafford, Michelle Sinclair, Jane Turner, Louise Newman, Claire Wakefield, Mei Krishnasamy, G Bruce Mann, Leslie Gilham, Kylie Mason, Paula Rauch, Julia Cannell, Penelope Schofield
Background: Parents with cancer have high rates of psychological morbidity, and their children are at risk of poor psychosocial outcomes, particularly in the context of parental distress and poor family communication. Parents express concerns about the impact of cancer on their children and report a lack of professional guidance in meeting their children's needs. Few parenting interventions exist and current interventions have extensive infrastructure demands making them unsuitable for routine use in most health settings...
2017: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29237718/use-of-pro-measures-to-inform-tolerability-in-oncology-trials-implications-for-clinical-review-ind-safety-reporting-and-clinical-site-inspections
#17
Janice Kim, Harpreet Singh, Kassa Ayalew, Kristina Borror, Michelle Campbell, Laura Lee Johnson, Alyson Karesh, Ni A Khin, Joanne R Less, Jerry Menikoff, Lori Minasian, Sandra A Mitchell, Elektra J Papadopoulos, Richard L Piekarz, Kevin A Prohaska, Susan Thompson, Rajeshwari Sridhara, Richard Pazdur, Paul G Kluetz
Cancer therapeutics frequently lead to symptomatic adverse events (AEs) that can affect treatment tolerability. The National Cancer Institute has developed a patient-reported outcome (PRO) version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) to assess symptomatic AEs by direct patient self-report. While longitudinal assessment of patient-reported symptomatic AEs holds promise to better inform treatment tolerability, using PRO measures to assess symptomatic AEs has raised several regulatory and good clinical practice (GCP) issues among those who conduct cancer clinical trials...
December 13, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29237083/relationship-between-patient-reported-outcomes-and-clinical-outcomes-in-metastatic-castration-resistant-prostate-cancer-post-hoc-analysis-of-cou-aa-301-and-cou-aa-302
#18
D Cella, S Traina, T Li, K Johnson, K F Ho, A Molina, N D Shore
Background: Patient-reported outcomes (PROs) are used to assess benefit-risk in drug development. The relationship between PROs and clinical outcomes is not well understood. We aimed to elucidate the relationships between changes in PRO measures and clinical outcomes in metastatic castration-resistant prostate cancer (mCRPC). Patients and methods: We investigated relationships between changes in self-reported fatigue, pain, functional well-being (FWB), physical well-being (PWB) and prostate cancer-specific symptoms with overall survival (OS) and radiographic progression-free survival (rPFS) after 6 and 12 months of treatment in COU-AA-301 (N = 1195) or COU-AA-302 (N = 1088)...
December 11, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29237009/recent-trends-in-chemotherapy-use-and-oncologists-treatment-recommendations-for-early-stage-breast-cancer
#19
Allison W Kurian, Irina Bondarenko, Reshma Jagsi, Christopher R Friese, M Chandler McLeod, Sarah T Hawley, Ann S Hamilton, Kevin C Ward, Timothy P Hofer, Steven J Katz
Background: There is growing concern about overtreatment of breast cancer as outcomes have improved over time. However, little is known about how chemotherapy use and oncologists' recommendations have changed in recent years. Methods: We surveyed 5080 women (70% response rate) diagnosed with breast cancer between 2013 and 2015 and accrued through two Surveillance, Epidemiology, and End Results registries (Georgia and Los Angeles) about chemotherapy receipt and their oncologists' chemotherapy recommendations...
December 11, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29236321/murine-models-of-osteosarcoma-a-piece-of-the-translational-puzzle
#20
Mannu K Walia, Wilson Castillo-Tandazo, Anthony J Mutsaers, T John Martin, Carl R Walkley
Osteosarcoma (OS) is the most common cancer of bone in children and young adults. Despite extensive research efforts, there has been no significant improvement in patient outcome for many years. An improved understanding of the biology of this cancer and how genes frequently mutated contribute to OS may help improve outcomes for patients. Whilst our knowledge of the mutational burden of OS is approaching saturation, our understanding of how these mutations contribute to OS initiation and maintenance is less clear...
December 13, 2017: Journal of Cellular Biochemistry
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