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Patient-reported outcomes cancer

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https://www.readbyqxmd.com/read/29470807/longitudinal-effects-of-adjuvant-endocrine-therapy-on-the-quality-of-life-of-post-menopausal-women-with-non-metastatic-er-breast-cancer-a-systematic-review
#1
REVIEW
Hong Xiao, Xinyi Jiang, Cheng Chen, Alberto J Montero, Vakaramoko Diaby
BACKGROUND: Anti-estrogen (ER) endocrine therapy is an effective treatment strategy in reducing breast cancer mortality. This therapy has a better therapeutic index than chemotherapy but can still affect patients' quality of life (QOL) over time. OBJECTIVE: The objectives of this systematic review were to (1) describe QOL instruments used in ER-positive (ER+) non-metastatic breast cancer trials and (2) document the longitudinal effects of adjuvant endocrine therapy on the QOL of post-menopausal women with ER+ non-metastatic breast cancer...
February 22, 2018: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29470805/adjuvant-versus-neoadjuvant-chemotherapy-in-triple-negative-breast-cancer-patients-with-brca-mutations
#2
Katherine Clifton, Angelica Gutierrez-Barrera, Junsheng Ma, Roland Bassett, Jennifer Litton, Henry Kuerer, Stacy Moulder, Constance Albarracin, Gabriel Hortobagyi, Banu Arun
PURPOSE: As triple-negative breast cancers are associated with earlier recurrences and poorer survival, optimal treatment of early-stage breast cancer is essential. Several retrospective studies in triple-negative breast cancer have reported conflicting results in overall survival in patients receiving neoadjuvant or adjuvant systemic therapy. This study aims to analyze outcomes of adjuvant versus neoadjuvant in patients with early-stage triple-negative breast cancer with and without BRCA germline mutations...
February 22, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29470704/relationship-between-sleep-and-exercise-as-colorectal-cancer-survivors-transition-off-treatment
#3
Theresa Coles, Antonia V Bennett, Xianming Tan, Claudio L Battaglini, Hanna K Sanoff, Ethan Basch, Roxanne E Jensen, Bryce B Reeve
PURPOSE: The primary objective of this study was to evaluate the relationship between exercise and sleep disturbance in a sample of individuals diagnosed with stage I, II, and III colorectal cancer (CRC) as patients transitioned off first-line treatment. We also sought to identify heterogeneity in the relationship between sleep disturbance and exercise. METHODS: Data were obtained from the MY-Health study, a community-based observational study of adults diagnosed with cancer...
February 22, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29470233/can-a-nomogram-help-to-predict-the-overall-and-cancer-specific-survival-of-patients-with-chondrosarcoma
#4
Kehan Song, Xiao Shi, Hongli Wang, Fei Zou, Feizhou Lu, Xiaosheng Ma, Xinlei Xia, Jianyuan Jiang
BACKGROUND: Many factors have been reported to be associated with the prognosis of patients with chondrosarcoma, but clinicians have few tools to estimate precisely an individual patient's likelihood of surviving the illness. We therefore sought to develop effective nomograms to better estimate the survival of patients with chondrosarcoma. QUESTIONS/PURPOSES: (1) Which clinicopathologic features are independent prognostic factors for patients with chondrosarcoma? (2) Can we develop a nomogram to predict 3- and 5-year overall and cancer-specific survival of individual patients with chondrosarcoma based on personalized information? METHODS: We collected information on patients diagnosed with chondrosarcoma between 1988 and 2011 from the Surveillance, Epidemiology, and End Results (SEER) database...
February 21, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29469961/relapse-and-survival-after-transplantation-for-complex-karyotype-acute-myeloid-leukemia-a-report-from-the-acute-leukemia-working-party-of-the-european-society-for-blood-and-marrow-transplantation-and-the-university-of-texas-md-anderson-cancer-center
#5
Stefan O Ciurea, Myriam Labopin, Gerard Socie, Liisa Volin, Jakob Passweg, Patrice Chevallier, Dietrich Beelen, Noel Milpied, Didier Blaise, Jan J Cornelissen, Nathalie Fegueux, Emmanuelle Polge, Piyanuch Kongtim, Gabriela Rondon, Jordi Esteve, Mohamad Mohty, Bipin N Savani, Richard E Champlin, Arnon Nagler
BACKGROUND: Despite recent advances in allogeneic hematopoietic stem cell transplantation (AHSCT), the outcome of patients who have acute myeloid leukemia (AML) with a complex karyotype (CK) remains poor. The objective of this study was to identify prognostic factors associated with post-transplantation survival in a large cohort of patients with CK AML. METHODS: In total, data on 1342 consecutively patients who underwent transplantation for CK (≥3 chromosomal abnormalities) AML were provided by the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation and from the University of Texas MD Anderson Cancer Center database were included in the analysis...
February 22, 2018: Cancer
https://www.readbyqxmd.com/read/29469940/different-qualifiers-of-aus-flus-thyroid-fna-have-distinct-braf-ras-ret-ptc-and-pax8-pparg-alterations
#6
Claudio Bellevicine, Roberta Sgariglia, Ilaria Migliatico, Elena Vigliar, Melania D'Anna, Maria Antonia Nacchio, Nicola Serra, Umberto Malapelle, Massimo Bongiovanni, Giancarlo Troncone
BACKGROUND: The Bethesda System for Reporting Thyroid Cytopathology category of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) includes fine-needle aspiration (FNA) specimens that cannot straightforwardly be classified as benign or malignant. To determine whether morphological subcategorization based on atypia qualifiers and molecular testing could improve malignancy risk stratification of AUS/FLUS patients, this study assessed the correlation between these qualifiers and the molecular alterations commonly harbored by thyroid neoplasms...
February 22, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29469760/the-use-of-cyclosporine-for-stevens-johnson-syndrome-toxic-epidermal-necrolysis-spectrum-at-the-university-of-louisville-a-case-series-and-literature-review
#7
Clayton D Conner, Emily McKenzie, Cindy E Owen
INTRODUCTION: Cyclosporine therapy for Stevens-Johnson syndrome-toxic epidermal necrolysis (SJSTEN) was first reported in the literature by Renfro et al. in 1989. Herein we report an additional 4 cases of SJS-TEN treated with cyclosporine. METHODS: Case information was collected retroactively at the University of Louisville Hospital in Louisville, KY. All cases had a diagnosis of SJS or TEN by a dermatologist. All patients were ≥18 years of age and treated with cyclosporine during their admission...
January 1, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469077/carboplatin-based-concurrent-chemoradiation-therapy-in-locally-advanced-head-and-neck-cancer-patients-who-are-unfit-for-cisplatin-therapy
#8
V Noronha, V Sharma, A Joshi, V M Patil, S G Laskar, K Prabhash
BACKGROUND: Cisplatin-based chemoradiation (CTRT) is the standard of care in locally advanced head and neck cancers. Limited treatment options are available in patients unfit for cisplatin. AIMS: This audit was carried out to study the toxicities, tolerance, and outcomes of carboplatin-based CTRT in patients who are not eligible for cisplatin. MATERIALS AND METHODS: A total of 63 locally advanced head and neck cancer patients treated between January 2011 and October 2015 were administered carboplatin-based CTRT...
April 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29469073/ros1-rearranged-nonsmall-cell-lung-cancer-and-crizotinib-an-indian-experience
#9
V Noronha, M V Chandrakanth, A P Joshi, V Patil, A Chougule, A Mahajan, A K Janu, R Chanana, K Prabhash
ROS1 rearrangement acts as a driver mutation in 1-2% of NSCLC. Crizotinib is approved in this situation both in treatment naïve and pre-treated patients. Here we report our experience with crizotinib in patients with advanced NSCLC harbouring ROS1 rearrangement. Eleven patients were included in our study. More than half of our patients had associated comorbidities and one fourth of them had a compromised performance status. Out of 11 patients, 5 of them were exposed to crizotinib .The response rates among crizotinib treated patients was 80%...
April 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29468607/the-patient-reported-information-multidimensional-exploration-prime-framework-for-investigating-emotions-and-other-factors-of-prostate-cancer-patients-with-low-intermediate-risk-based-on-online-cancer-support-group-discussions
#10
Tharindu Bandaragoda, Weranja Ranasinghe, Achini Adikari, Daswin de Silva, Nathan Lawrentschuk, Damminda Alahakoon, Raj Persad, Damien Bolton
BACKGROUND: This study aimed to use the Patient Reported Information Multidimensional Exploration (PRIME) framework, a novel ensemble of machine-learning and deep-learning algorithms, to extract, analyze, and correlate self-reported information from Online Cancer Support Groups (OCSG) by patients (and partners of patients) with low intermediate-risk prostate cancer (PCa) undergoing radical prostatectomy (RP), external beam radiotherapy (EBRT), and active surveillance (AS), and to investigate its efficacy in quality-of-life (QoL) and emotion measures...
February 21, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29468435/additional-lymph-node-dissection-for-primary-colorectal-cancer-invading-another-colon-region
#11
Ryuma Tokunaga, Yasuo Sakamoto, Shigeki Nakagawa, Yuji Miyamoto, Naoya Yoshida, Hideo Baba
PURPOSE: Surgery remains the curative treatment of choice for colorectal cancer (CRC). However, to our knowledge, no report has addressed the usefulness of additional regional lymph node dissection for primary CRC that has invaded another colon region. METHODS: We reviewed the clinicopathological characteristics and outcomes of eight patients who underwent surgery between March, 2005 and August, 2014, for CRC that invaded another region of the colon. RESULTS: Five patients underwent additional regional lymph node dissection in the area of the invaded colon and one patient had lymph node metastasis in the region...
February 21, 2018: Surgery Today
https://www.readbyqxmd.com/read/29468434/preservation-of-the-nipple-areola-complex-in-skin-sparing-mastectomy-for-early-breast-cancer
#12
Ryo Miyake, Satoki Kinoshita, Naoko Shimada, Ken Uchida, Hiroshi Takeyama, Toshiaki Morikawa
PURPOSE: Skin-sparing mastectomy (SSM) enables a radical cure of breast cancer while overcoming the cosmetic issues related to surgery. We review our experience of performing SSMs and assess whether preservation of the nipple-areola complex (NAC) could have been an option for some patients who underwent SSM. METHODS: The subjects of this retrospective study were women who underwent SSM that utilized four incision types; namely, the so-called tennis racket incision, a periareolar and midaxillary incision, an areola-sparing and midaxillary incision, and a small transverse elliptical incision...
February 21, 2018: Surgery Today
https://www.readbyqxmd.com/read/29467138/-pathways-patient-centred-decision-counselling-for-women-at-risk-of-cancer-related-infertility-a-protocol-for-a-comparative-effectiveness-cluster-randomised-trial
#13
Terri Lynn Woodard, Aubri S Hoffman, Laura C Crocker, Deborah A Holman, Derek B Hoffman, Jusheng Ma, Roland L Bassett, Viola B Leal, Robert J Volk
INTRODUCTION: National guidelines recommend that all reproductive-age women with cancer be informed of their fertility risks and offered referral to fertility specialists to discuss fertility preservation options. However, reports indicate that only 5% of patients have consultations, and rates of long-term infertility-related distress remain high. Previous studies report several barriers to fertility preservation; however, initial success has been reported using provider education, patient decision aids and navigation support...
February 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29466412/determinants-of-satisfaction-with-cosmetic-outcome-in-breast-cancer-survivors-a-cross-sectional-study
#14
Peh Joo Ho, Mikael Hartman, Danny A Young-Afat, Sofie A M Gernaat, Soo Chin Lee, Helena M Verkooijen
Little research has been done into cosmetic outcomes in non-Western breast cancer populations. We aimed to study the prevalence and determinants of dissatisfaction with cosmetic outcome after breast cancer surgery of Asian breast cancer survivors, and its association with patient-reported anxiety, depression, and quality of life. In a hospital-based cross-sectional study, 384 breast cancer survivors of at least 12 months after diagnosis completed questionnaires on satisfaction with cosmetic appearance, quality of life (EORTC-QLQ-C30) and anxiety and depression (HADS)...
2018: PloS One
https://www.readbyqxmd.com/read/29466345/symptom-dimensions-as-outcomes-in-interventions-for-patients-with-cancer-a-systematic-review
#15
Ingela Henoch, Cecilia Olsson, Maria Larsson, Karin Ahlberg
PROBLEM IDENTIFICATION: Symptom experience in patients with cancer consists of several dimensions, often measured descriptively within various populations but seldom used as intervention outcomes. This review aims at describing symptom dimensions as outcomes of interventions designed to alleviate symptoms in patients with cancer and to describe these interventions' effects on at least two symptom dimensions. 
. LITERATURE SEARCH: The PRISMA statement for reporting systematic reviews was used...
March 1, 2018: Oncology Nursing Forum
https://www.readbyqxmd.com/read/29466257/recurrent-cancer-is-associated-with-dissatisfaction-with-care-a-longitudinal-analysis-among-ovarian-and-endometrial-cancer-patients
#16
Belle H de Rooij, Habibe Ikiz, Dorry Boll, Johanna M A Pijnenborg, Brenda M Pijlman, Roy F P M Kruitwagen, Lonneke V van de Poll-Franse, M Caroline Vos, Nicole P M Ezendam
OBJECTIVE: The primary aim of this study was to assess the longitudinal impact of a recurrence of gynecological cancer on satisfaction with information provision and care. The secondary aim was to assess the impact of a recurrence on illness perceptions, anxiety, and depression and health-related quality of life. METHODS: This study is a longitudinal analysis from the ROGY Care trial, conducted between 2011 and 2014, including patients with endometrial (n = 215) and ovarian (n = 149) cancer...
March 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29465789/a-real-world-experience-with-augmentation-enterocystoplasty-high-patient-satisfaction-with-high-complication-rates
#17
Shu-Yu Wu, Hann-Chorng Kuo
AIMS: To investigate the real treatment outcomes after augmentation enterocystoplasty (AE) of patients with refractory neurogenic lower urinary tract dysfunction. METHODS: Retrospective follow-up in a single center. The videourodynamic data, renal function, incontinence grade, voiding pattern and management, clinical outcome, and complications were evaluated. RESULTS: Seventy-nine patients (62 men and 17 women) were included. The mean age at operation was 39...
February 21, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29465553/prognostic-role-of-platelet-to-lymphocyte-ratio-in-pancreatic-cancers-a-meta-analysis-including-3028-patients
#18
Wendi Li, Lianyuan Tao, Meng Lu, Dianrong Xiu
BACKGROUND: Platelet to lymphocyte ratio (PLR) was recently reported being associated with the prognosis of pancreatic cancer (PC), but the prognostic value of PLR in pancreatic cancer remains inconsistent. We conduct a meta-analysis to evaluate the prognostic role of PLR in patients with PC. METHODS: PubMed, Embase, Cochrane Library, and Web of Science were systematically searched for eligible studies which investigated the relationship between PLR and clinical outcome of patients with pancreatic cancer...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29465538/enhanced-recovery-after-surgery-eras-programs-for-esophagectomy-protocol-for-a-systematic-review-and-meta-analysis
#19
Feiyu Liu, Wei Wang, Chengde Wang, Xiaonu Peng
BACKGROUND: Esophageal cancer is one of the worst malignant digestive neoplasms with poor treatment outcomes. Esophagectomy plays an important role and offers a potential curable chance to these patients. However, esophagectomy with radical lymphadenectomy is known as one of the most invasive digestive surgeries which are associated with high morbidity and mortality. The enhanced recovery after surgery (ERAS) protocol is a patient-centered, surgeon-led system combining anesthesia, nursing, nutrition, and psychology, which is designed for reducing complications, promoting recovery, and improving treatment outcomes...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29465316/orbital-invasion-routes-of-non-melanoma-skin-cancers-and-survival-outcomes
#20
Yusuf Dundar, Richard Cannon, Richard Wiggins, Marcus M Monroe, Luke O Buchmann, Jason P Hunt
PURPOSE/OBJECTIVES: Overall non-melanoma head and neck skin cancer has a good prognosis; however, rarely patients have an aggressive variant which results in orbital invasion via perineural spread or direct extension. Despite these consequences, there are limited published studies defining this clinical entity. The main objectives of the current study are to describe orbital invasion patterns of non-melanoma head and neck skin cancers and their impact on survival. METHODS: Retrospective case series from a tertiary-care, academic institution performed between 2004 and 2014...
February 21, 2018: Orbit
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