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https://www.readbyqxmd.com/read/29667882/new-doppler-imaging-technique-for-assessing-angiogenesis-in-breast-tumors-correlation-with-immunohistochemically-analyzed-microvessels-density
#1
Sewha Kim, Hye Jin Lee, Kyung Hee Ko, Ah Young Park, Jieun Koh, Hae Kyoung Jung
Background Microvessel density (MVD) is associated with grade and prognosis in breast tumors. However, conventional color Doppler flow (CDF) imaging has been limited to represent MVD of breast tumors. Purpose To evaluate whether a new Doppler imaging technique (AngioPLUS) can represent MVD of breast tumors. Material and Methods The institutional review board approved this retrospective study, and patients' informed consent was waived. CDF and AngioPLUS were available in pathologically confirmed 55 breast tumors of 53 women...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29667115/biopsy-feasibility-trial-for-breast-cancer-pathologic-complete-response-detection-after-neoadjuvant-chemotherapy-imaging-assessment-and-correlation-endpoints
#2
Gaiane M Rauch, Henry M Kuerer, Beatriz Adrada, Lumarie Santiago, Tanya Moseley, Rosalind P Candelaria, Elsa Arribas, Jia Sun, Jessica W T Leung, Savitri Krishnamurthy, Wei T Yang
PURPOSE: This study was designed to present the secondary imaging endpoints of the trial for evaluating mammogram (MMG), ultrasound (US) and image guided biopsy (IGBx) assessment of pathologic complete response (pCR) in breast cancer (BC) patients undergoing neoadjuvant chemotherapy (NAC). METHODS: Patients with T1-3, N0-3, M0 triple-negative or HER2-positive BC who received NAC were enrolled in an Institutional Review Board-approved prospective, clinical trial...
April 17, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29664796/long-term-outcomes-with-ifosfamide-based-hypofractionated-preoperative-chemoradiotherapy-for-extremity-soft-tissue-sarcomas
#3
Joseph Daniel Pennington, Fritz C Eilber, Frederick R Eilber, Arun S Singh, Jarred P Reed, Bartosz Chmielowski, Jeffrey J Eckardt, Susan V Bukata, Nicholas M Bernthal, Noah Federman, Scott D Nelson, Sarah M Dry, Pin-Chieh Wang, Michael Luu, Michael T Selch, Michael L Steinberg, Anusha Kalbasi, Mitchell Kamrava
OBJECTIVES: The objective of this study was to analyze outcomes for patients with soft tissue sarcoma of the extremities using neoadjuvant ifosfamide-based chemotherapy and hypofractionated reduced dose radiotherapy, followed by limb-sparing surgery. MATERIALS AND METHODS: An Institutional Review Board (IRB)-approved retrospective review of patients treated at a single institution between 1990 and 2013 was performed. In total, 116 patients were identified who received neoadjuvant ifosfamide-based chemotherapy and 28 Gy in 8 fractions of preoperative radiation (equivalent dose in 2 Gray fractions, 31...
April 16, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29664358/tailored-management-of-stage-iiia-non-small-cell-lung-cancer-in-the-era-of-the-8th-edition-of-the-tnm-classification-for-lung-cancer
#4
Michael R Mueller
Stage IIIA is a very heterogeneous group encompassing locally advanced disease with T3 and T4 tumors without any nodal involvement and very small T1a primary tumors with unilateral mediastinal lymphatic disease. Tailored management defines interdisciplinary management requiring board decisions, which can sometimes be difficult particularly in stage IIIa non-small-cell lung cancer (NSCLC). Lobectomy still is standard of care even for stage I NSCLC, which increasingly is implemented using minimally invasive surgical technique...
March 2018: Future Oncology
https://www.readbyqxmd.com/read/29663025/imaging-appearance-of-well-differentiated-liposarcomas-with-myxoid-stroma
#5
Yoav Morag, Corrie Yablon, Monica Kalume Brigido, Jon Jacobson, David Lucas
OBJECTIVE: Describe the imaging appearance of well-differentiated liposarcoma with myxoid stroma (WDLMS) and correlate with histopathology. MATERIALS AND METHODS: A keyword search of the institution medical records was performed from 1 January 2000 to 30 June 2017. The histopathology slides of cases identified in this fashion were then reviewed by a pathologist. Additional cases were prospectively collected from extramural referrals and tumor boards. Diagnostic imaging studies of pathologically proven cases of WDLMS were then reviewed in consensus and correlated with pathology...
April 16, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29661274/granular-cell-tumor-experience-at-a-comprehensive-cancer-center
#6
Ambria S Moten, Sujana Movva, Margaret von Mehren, Hong Wu, Nestor F Esnaola, Sanjay S Reddy, Jeffrey M Farma
BACKGROUND: Granular cell tumors (GCTs) are rare lesions occurring almost anywhere in the body. Multiple case reports have been published. However, there are very few large-scale studies regarding GCT. The aim of this study was to define characteristics, treatment patterns and outcomes of patients with GCT. METHODS: An institutional review board-approved retrospective chart review was performed. Descriptive statistics, chi-square analyses, and Kaplan-Meier survival estimates were produced...
June 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29660010/costs-for-breast-cancer-care-in-the-military-health-system-an-analysis-by-benefit-type-and-care-source
#7
Yvonne L Eaglehouse, Janna Manjelievskaia, Stephanie Shao, Derek Brown, Keith Hofmann, Patrick Richard, Craig D Shriver, Kangmin Zhu
Introduction: Breast cancer care imposes a significant financial burden to U.S. healthcare systems. Health services factors, such as insurance benefit type and care source, may impact costs to the health system. Beneficiaries in the U.S. Military Health System (MHS) have universal healthcare coverage and access to a network of military facilities (direct care) and private practices (purchased care). This study aims to quantify and compare breast cancer care costs to the MHS by insurance benefit type and care source...
April 11, 2018: Military Medicine
https://www.readbyqxmd.com/read/29657891/stereotactic-radiosurgery-for-primary-tumors-of-the-spine-and-spinal-cord-%C3%A2
#8
Erinma Elibe, David Boyce-Fappiano, Samuel Ryu, M Salim Siddiqui, Ian Lee, Jack Rock, Farzan Siddiqui
Purpose: The purpose of this study was to evaluate the role of stereotactic radiosurgery in the treatment of primary tumors of the spine and spinal cord. Methods: An Institutional Review Board approved retrospective analysis of 30 patients with primary spine tumors treated at a single institution was performed. Post-treatment pain, neurological, and radiographic responses were the endpoints. Results: Nine patients were treated for benign tumors, and 21 patients were treated for malignant tumors...
2018: Journal of Radiosurgery and SBRT
https://www.readbyqxmd.com/read/29649676/intradural-spinal-tumors-10-years-surgical-experience-in-a-single-institution
#9
Pablo David Guerrero-Suarez, Ernesto Magdaleno-Estrella, Paola Guerrero-López, Arturo Isaac Vargas-Figueroa, Jaime Jesús Martínez-Anda
OBJECTIVES: The aim of the study is to present the therapeutic results of intradural tumor management over a 10 years period in a single institution. PATIENTS AND METHODS: The study consists in a prospective case series of patients treated at the neurosurgery service of the Social Security Institute of Mexico State and Provinces (ISSSEMYM), between January 2006 and December 2016. All patients were provided with information about the procedure and signed informed consent and institutional board approved files review for this study...
March 10, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29629795/mri-detection-of-intratumoral-fat-in-colorectal-liver-metastases-after-preoperative-chemotherapy
#10
Yudai Nakai, Wataru Gonoi, Akifumi Hagiwara, Yujiro Nishioka, Hiroyuki Abe, Junichi Shindoh, Kiyoshi Hasegawa
OBJECTIVE: The objective of this study was to investigate the incidence and clinical significance of intratumoral fat deposition in colorectal liver metastases (CLMs) after preoperative chemotherapy using dual-echo gradient-recalled echo MRI. MATERIALS AND METHODS: Our institutional review board approved this retrospective radiographic study and waived the requirement for informed patient consent. Fifty-nine patients (33 men, 26 women; median age, 62 years old) who underwent preoperative MRI and curative hepatic resection for colorectal liver metastases after chemotherapy were selected...
April 9, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29623910/evaluation-of-the-sharkcore-%C3%A2-needle-for-eus-guided-core-biopsy-of-pancreatic-neuroendocrine-tumors
#11
Benjamin L Witt, Rachel E Factor, Barbara E Chadwick, Justin Caron, Ali A Siddiqui, Douglas G Adler
Background and Objectives: EUS guided core biopsy was once rarely performed but is now entering mainstream practice. Neuroendocrine tumors often warrant core biopsy as sufficient tissue must be obtained to allow for special staining to ensure a correct diagnosis. Traditionally these lesions were sampled with FNA needles. We performed a retrospective pilot study to evaluate the clinical value and efficacy of the a new EUS core needle biopsy needle as compared to a standard EUS FNA needle in the evaluation of patients with known or suspected neuroendocrine tumors...
April 4, 2018: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29622373/antidepressants-appear-safe-in-patients-with-carcinoid-tumor-results-of-a-restrospective-review
#12
Elie Isenberg-Grzeda, Meredith MacGregor, Afton Bergel, Stacy Eagle, Fernando Espi-Forcen, Reema Mehta, Konstantina Matsoukas, Jonathan Wills, Diane Reidy-Lagunes, Yesne Alici
INTRODUCTION: Patients living with neuroendocrine tumors have high rates of depression, often necessitating antidepressants, including selective serotonin reuptake inhibitors (SSRI). Neuroendocrine tumors (NETs) secrete vasoactive substances, including serotonin, which contribute to the cluster of symptoms known as carcinoid syndrome (flushing and diarrhea). Controversy exists over whether or not antidepressants are safe in NET. We aimed to study the safety of antidepressant use in NET patients...
March 21, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29622044/ultrasound-shear-wave-elastography-of-breast-lesions-correlation-of-anisotropy-with-clinical-and-histopathological-findings
#13
Ya-Ling Chen, Yi Gao, Cai Chang, Fen Wang, Wei Zeng, Jia-Jian Chen
BACKGROUND: Ultrasound shear-wave elastography (SWE) may increase specificity of breast lesion assessment with ultrasound, but elasticity measurements may change with transducer orientation, defined as anisotropy. In this study, we aimed to observe the anisotropy of SWE of breast lesions, and its correlation with clinical and histopathological findings. METHODS: This retrospective study was approved by institutional review board. From June 2014 to June 2015, a total of 276 women (mean age, 48...
April 5, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/29621612/laparoscopic-anterior-pelvic-exenteration-with-super-radical-parametrectomy-for-a-recurrent-low-grade-endometrial-sarcoma-that-is-resistant-to-hormone-therapy-and-chemotherapy
#14
Hiroyuki Kanao, Tsuyoshi Hisa, Makiko Omi, Minoru Nagashima, Shuhei Okamoto, Yoichi Aoki, Terumi Tanigawa, Maki Matoda, Sanshiro Okamoto, Hidetaka Nomura, Kohei Omatsu, Kazuyoshi Kato, Kuniko Utsugi, Nobuhiro Takeshima
STUDY OBJECTIVE: To show total laparoscopic complete resection of a recurrent low grade endometrial sarcoma. DESIGN: Step-by-step demonstration of the technique of laparoscopic anterior pelvic exenteration with super radical parametrectomy, including the explanation of a detail pelvic anatomy. (Canadian Task Force Classification III) SETTING: Low grade endometrial stromal sarcoma (LGESS) is a rare malignancy that makes around 0.2% of all uterine malignancies [1]...
April 2, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29620604/diffusion-weighted-imaging-with-apparent-diffusion-coefficient-mapping-for-breast-cancer-detection-as-a-stand-alone-parameter-comparison-with-dynamic-contrast-enhanced-and-multiparametric-magnetic-resonance-imaging
#15
Katja Pinker, Linda Moy, Elizabeth J Sutton, Ritse M Mann, Michael Weber, Sunitha B Thakur, Maxine S Jochelson, Zsuzsanna Bago-Horvath, Elizabeth A Morris, Pascal At Baltzer, Thomas H Helbich
PURPOSE: The aims of this study were to compare dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI) with apparent diffusion coefficient mapping as a stand-alone parameter without any other supportive sequence for breast cancer detection and to assess its combination as multiparametric MRI (mpMRI) of the breast. MATERIALS AND METHODS: In this institutional review board-approved single-center study, prospectively acquired data of 106 patients who underwent breast MRI from 12/2010 to 09/2014 for an imaging abnormality (Breast Imaging Reporting and Data System 0, 4/5) were retrospectively analyzed...
April 3, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29619578/efficiency-improvement-in-a-busy-radiology-practice-determination-of-musculoskeletal-magnetic-resonance-imaging-protocol-using-deep-learning-convolutional-neural-networks
#16
Young Han Lee
The purposes of this study are to evaluate the feasibility of protocol determination with a convolutional neural networks (CNN) classifier based on short-text classification and to evaluate the agreements by comparing protocols determined by CNN with those determined by musculoskeletal radiologists. Following institutional review board approval, the database of a hospital information system (HIS) was queried for lists of MRI examinations, referring department, patient age, and patient gender. These were exported to a local workstation for analyses: 5258 and 1018 consecutive musculoskeletal MRI examinations were used for the training and test datasets, respectively...
April 4, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29616903/sinonasal-ewing-sarcoma-a-case-report-and-literature-review
#17
Jonathan K Lin, Jonathan Liang
INTRODUCTION: Ewing sarcoma (ES) of the sinonasal tract and associated primitive neuroectodermal tumors are rare. To our knowledge, only 10 case reports of sinonasal ES of the nose or paranasal sinuses have been reported. Furthermore, there has been only 1 case of sinonasal ES arising from the middle turbinate. Recommended management of sinonasal ES stems from the management of its osseous counterpart, ES, but treatment with surgery, radiotherapy, and chemotherapy is varied. Five-year survival rates vary from 21% to 70%, with the lower rates representing patients presenting with metastatic disease...
March 7, 2018: Permanente Journal
https://www.readbyqxmd.com/read/29610395/the-future-of-cancer-treatment-using-precision-oncogenomics
#18
Lukas D Wartman
Clinicians should soon have the opportunity to use precision oncogenomics to tailor the optimal cancer treatment to a specific patient. Precision oncogenomics will incorporate different sequencing platforms depending on the goal of the sequencing result. For example, the sequencing strategy used in immuno-oncology for the design of a tumor-specific vaccine may be different than that used by oncologists following a patient for clearance of mutations from circulating tumor DNA in the peripheral blood. I will provide a broad overview of several of the ways that precision oncogenomics is likely to influence the field of oncology over the next several years building off the experience at the Genomics Tumor Board at Washington University in St...
April 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29610388/clinically-actionable-mutation-profiles-in-patients-with-cancer-identified-by-whole-genome-sequencing
#19
Anna Schuh, Helene Dreau, Samantha J L Knight, Kate Ridout, Tuba Mizani, Dimitris Vavoulis, Richard Colling, Pavlos Antoniou, Erika M Kvikstad, Melissa M Pentony, Angela Hamblin, Andrew Protheroe, Marina Parton, Ketan A Shah, Zsolt Orosz, Nick Athanasou, Bass Hassan, Adrienne M Flanagan, Ahmed Ahmed, Stuart Winter, Adrian Harris, Ian Tomlinson, Niko Popitsch, David Church, Jenny C Taylor
Next-generation sequencing (NGS) efforts have established catalogs of mutations relevant to cancer development. However, the clinical utility of this information remains largely unexplored. Here, we present the results of the first eight patients recruited into a clinical whole-genome sequencing (WGS) program in the United Kingdom. We performed PCR-free WGS of fresh frozen tumors and germline DNA at 75× and 30×, respectively, using the HiSeq2500 HTv4. Subtracted tumor VCFs and paired germlines were subjected to comprehensive analysis of coding and noncoding regions, integration of germline with somatically acquired variants, and global mutation signatures and pathway analyses...
April 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29605024/benchmarking-rectal-cancer-care-institutional-compliance-with-a-longitudinal-checklist
#20
William C Chapman, Pamela Choi, Alexander T Hawkins, Steven R Hunt, Matthew L Silviera, Paul E Wise, Matthew G Mutch, Sean C Glasgow
BACKGROUND: In 2012, the American Society of Colon and Rectal Surgeons published the Rectal Cancer Surgery Checklist, a consensus document listing 25 essential elements of care for all patients undergoing radical surgery for rectal cancer. The authors herein examine checklist adherence in a mature, multisurgeon specialty academic practice. MATERIALS AND METHODS: A retrospective medical record review of patients undergoing elective radical resection for rectal adenocarcinoma over a 23-mo period was conducted...
May 2018: Journal of Surgical Research
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