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https://www.readbyqxmd.com/read/29932307/surgically-resected-t1-and-t2-stage-esophageal-squamous-cell-carcinoma-t-and-n-staging-performance-of-eus-and-pet-ct
#1
Dong Young Jeong, Min Yeong Kim, Kyung Soo Lee, Joon Young Choi, Soo Jeong Kim, Myung Jin Chung, Yang Won Min, Hong Kwan Kim, Jae Ill Zo, Young Mog Shim, Jong-Mu Sun
This study aimed to evaluate the frequency of nodal metastases and to disclose the diagnostic performance of endoscopic ultrasonography (EUS) and PET/CT in T and N staging in surgically resected early-stage esophageal squamous cell carcinomas (eSCCs). Institutional review board approved this retrospective study with waiver of informed consent for reviewing medical record. We included 435 patients with an early T-stage (Tis or T1a [≤T1a], T1b and T2) eSCC. The rates of metastatic lymphadenopathy were calculated...
June 22, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29931180/quantitative-clinical-staging-for-patients-with-malignant-pleural-mesothelioma
#2
Ritu R Gill, Beow Y Yeap, Raphael Bueno, William G Richards
Background: Analysis of the International Association for the Study of Lung Cancer (IASLC) Malignant Pleural Mesothelioma (MPM) database revealed that clinical (cTNM) staging minimally stratified survival and was discrepant with pathological (pTNM) staging. To improve prognostic classification of MPM, alternative staging models based on quantitative parameters were explored. Methods: An institutional review board-approved MPM registry was queried to identify patients with available pathological and preoperative imaging data...
March 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29908563/cerebellar-liponeurocytoma-a-rare-entity-a-case-report
#3
Oliver Gembruch, Andreas Junker, Yahya Ahmadipour, Ulrich Sure, Elias Lemonas
BACKGROUND: Cerebellar liponeurocytoma is a rare tumor of the central nervous system occurring mainly in the posterior fossa, which shows neuronal and variable astrocytic differentiation with foci of lipomatous differentiation. Liponeurocytoma develops in adult patients and is defined in the World Health Organization classification of 2016 as a rare benign grade II tumor. CASE PRESENTATION: A 39-year-old Italian man presented to our department suffering from headache and nausea...
June 17, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29901853/deep-learning-based-computer-aided-classifier-developed-with-a-small-dataset-of-clinical-images-surpasses-board-certified-dermatologists-in-skin-tumor-diagnosis
#4
Y Fujisawa, Y Otomo, Y Ogata, Y Nakamura, R Fujita, Y Ishitsuka, R Watanabe, N Okiyama, K Ohara, M Fujimoto
BACKGROUND: Application of deep-learning technology to skin cancer classification can potentially improve skin cancer screening sensitivity and specificity, but the number of training images required for such system is thought to be extremely large. OBJECTIVE: To determine if deep-learning technology could be used to develop an efficient skin cancer classifying system with a relatively small dataset of clinical images. METHODS: A deep convolutional neural network (DCNN) was trained using a dataset of 4867 clinical images obtained from 1842 patients diagnosed with skin tumors at the University of Tsukuba Hospital from 2003 to 2016...
June 14, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29891105/are-mammographically-occult-additional-tumors-identified-more-than-2-cm-away-from-the-primary-breast-cancer-on-mri-clinically-significant
#5
Sarah Goodman, Victoria Mango, Lauren Friedlander, Elise Desperito, Ralph Wynn, Richard Ha
RATIONALE AND OBJECTIVES: To evaluate the clinical significance of mammographically occult additional tumors identified more than 2cm away from the primary breast cancer on preoperative magnetic resonance imaging (MRI). MATERIALS AND METHODS: An Institutional Review Board approved review of consecutive preoperative breast MRIs performed from 1/1/08 to 12/31/14, yielded 667 patients with breast cancer. These patients underwent further assessment to identify biopsy proven mammographically occult breast tumors located more than 2cm away from the edge of the primary tumor...
June 8, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29888982/differentiating-solid-non-macroscopic-fat-containing-enhancing-renal-masses-using-fast-fourier-transform-analysis-of-multiphase-ct
#6
Bino A Varghese, Frank Chen, Darryl H Hwang, Steven Y Cen, Inderbir S Gill, Vinay A Duddalwar
OBJECTIVE: To test the feasibility of 2D fast Fourier transforms (FFT)-based imaging metrics in differentiating solid, non-macroscopic fat containing, enhancing renal masses using contrast-enhanced computed tomography (CECT) images. We quantify image-based intra-tumoral textural variations (indicator of tumor heterogeneity) using frequency-based (FFT) imaging metrics. METHODS: In this Institutional Review Board (IRB) approved, Health Insurance Portability and Accountability Act (HIPAA) compliant, retrospective case-control study, we evaluated 156 patients with predominantly solid, non-macroscopic fat containing, enhancing renal masses identified between June 2009 and June 2016...
June 11, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29887793/molecular-tumor-boards
#7
Achim Rody, Johannes Ettl, Frederik Marmé, Aleix Prat
No abstract text is available yet for this article.
April 2018: Breast Care
https://www.readbyqxmd.com/read/29882196/prone-positioning-on-a-belly-board-decreases-rectal-and-bowel-doses-in-pelvic-intensity-modulated-radiation-therapy-imrt-for-prostate-cancer
#8
Renáta Kószó, Linda Varga, Emese Fodor, Zsuzsanna Kahán, Adrienne Cserháti, Katalin Hideghéty, Zsófia Együd, Csilla Szabó, Emőke Borzási, Dorottya Szabó, Kitti Müllner, Zoltán Varga, Anikó Maráz
The presence of normal tissues in the irradiated volume limits dose escalation during pelvic radiotherapy (RT) for prostate cancer. Supine and prone positions on a belly board were compared by analyzing the exposure of organs at risk (OARs) using intensity modulated RT (IMRT). The prospective trial included 55 high risk, localized or locally advanced prostate cancer patients, receiving definitive image-guided RT. Computed tomography scanning for irradiation planning was carried out in both positions. Gross tumor volume, clinical and planning target volumes (PTV) and OARs were delineated, defining subprostatic and periprostatic rectal subsegments...
June 7, 2018: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29877957/change-in-eyelid-carcinoma-t-category-with-use-of-the-8th-versus-7th-edition-of-the-american-joint-committee-on-cancer-cancer-staging-manual
#9
Stephanie Ding, Oded Sagiv, Yunxia Guo, Thomas J Kandl, Sudip D Thakar, Bita Esmaeli
PURPOSE: To evaluate the frequency and nature of changes in T category when eyelid carcinomas are staged using the criteria in the 8th edition instead of the 7th edition of the American Joint Committee on Cancer staging manual. METHODS: Following Institutional Review Board approval, a retrospective review was conducted for all consecutive patients with the diagnosis of eyelid carcinoma treated by the senior author from January 2012 through December 2016. After a review of the clinical and pathologic data, each patient's disease was staged using both the 7th-edition and 8th-edition American Joint Committee on Cancer criteria for eyelid carcinomas...
June 5, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29875799/liver-resection-for-non-colorectal-metastases
#10
Christoph Schwarz, Klaus Kaczirek, Martin Bodingbauer
Whereas liver resection for colorectal metastasis has become standard of care, hepatectomy in patients with non-colorectal metastases remains controversial, mainly due to a heterogeneous tumor biology and missing data from prospective trials. This review aims at giving an overview about the indications and limits of liver surgery in patients with an advanced disease of a non-colorectal malignancy. Even though prospective trials are largely missing, results from retrospective studies indicate a survival benefit for liver resection in selected patients...
2018: European Surgery: ACA: Acta Chirurgica Austriaca
https://www.readbyqxmd.com/read/29872644/response-to-her2-inhibition-in-a-patient-with-brain-metastasis-with-egfr-tki-acquired-resistance-and-an-her2-amplification
#11
Arenda D Meedendorp, Arja Ter Elst, Nils A 't Hart, Harry J M Groen, Ed Schuuring, Anthonie J van der Wekken
A 62-year-old man was referred to our university hospital for treatment of advanced adenocarcinoma of the lung after disease progression on two lines of EGFR TKI and one line of chemotherapy. Fluorescent in situ hybridization analysis upon progression showed an HER2 amplification. At our weekly Molecular Tumor Board (MTB), a decision was made to treat this patient with afatinib, which resulted in a partial response. However, progression was observed with a facial nerve paresis due to a metastasis in the skull...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29872643/three-dimensional-map-of-isoprognostic-zones-in-glottic-cancer-treated-by-transoral-laser-microsurgery-as-a-unimodal-treatment-strategy
#12
Cesare Piazza, Marta Filauro, Alberto Paderno, Filippo Marchi, Pietro Perotti, Riccardo Morello, Stefano Taboni, Giampiero Parrinello, Fabiola Incandela, Andrea Iandelli, Francesco Missale, Giorgio Peretti
Introduction: The Union for International Cancer Control-American Joint Committee on Cancer TNM staging system for glottic squamous cell carcinoma (SCC) includes different types of lesions defined by the involvement of specific subsites in each T category. Our study aims to identify different subcategories according to tumor local extension and determine oncologic outcomes after treatment by transoral laser microsurgery (TLM) alone. Methods: We retrospectively evaluated 410 patients affected by previously untreated pT1-pT3 glottic SCC treated by TLM alone from January 2005 to December 2015 at the Departments of Otorhinolaryngology-Head and Neck Surgery, Universities of Genoa and Brescia, Italy...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29869174/ct-perfusion-imaging-of-lung-cancer-benefit-of-motion-correction-for-blood-flow-estimates
#13
Lisa L Chu, Robert J Knebel, Aryan D Shay, Jonathan Santos, Ramsey D Badawi, David R Gandara, Friedrich D Knollmann
PURPOSE: CT perfusion (CTP) imaging assessment of treatment response in advanced lung cancer can be compromised by respiratory motion. Our purpose was to determine whether an original motion correction method could improve the reproducibility of such measurements. MATERIALS AND METHODS: The institutional review board approved this prospective study. Twenty-one adult patients with non-resectable non-small-cell lung cancer provided written informed consent to undergo CTP imaging...
June 4, 2018: European Radiology
https://www.readbyqxmd.com/read/29868325/esthesioneuroblastoma-and-olfactory-preservation-is-it-reasonable-to-attempt-smell-preservation
#14
Jamie J Van Gompel, Jeffrey R Janus, Joshua D Hughes, Janalee K Stokken, Eric J Moore, Tarek Ryan, Daniel L Price, Michael J Link
Objective  Olfactory preservation after resection of esthesioneuroblastoma (ENB) has been reported, however, the ability to predict tumor involvement of the olfactory system is critical to this surgical strategy. This study aims to answer the question: Can a surgeon predict, based on preoperative imaging, whether there is unilateral involvement of the olfactory system allowing for safe attempt of olfactory preservation? Methods  This is a retrospective review of post-resection ENB meeting inclusion criteria of having bilateral olfactory tracts and bulbs submitted at the time of primary resection for pathologic margins...
April 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29866627/radiologist-quality-assurance-by-nonradiologists-at-tumor-board
#15
William R Masch, Neehar D Parikh, Tracy L Licari, Mishal Mendiratta-Lala, Matthew S Davenport
PURPOSE: To explore the use of nonradiologists as a method to efficiently reduce bias in the assessment of radiologist performance using a hepatobiliary tumor board as a case study. MATERIALS AND METHODS: Institutional review board approval was obtained for this HIPAA-compliant prospective quality assurance (QA) effort. Consecutive patients with CT or MR imaging reviewed at one hepatobiliary tumor board between February 2016 and October 2016 (n = 265) were included...
June 1, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29858937/hepatic-neuroendocrine-tumors-gadoxetic-acid-enhanced-magnetic-resonance-imaging-findings-with-an-emphasis-on-differentiation-between-primary-and-secondary-tumors
#16
Dong Ik Cha, Tae Wook Kang, Kyoung Mi Jang, Young Kon Kim, Seong Hyun Kim, Sang Yun Ha, Insuk Sohn
PURPOSE: To describe the findings of magnetic resonance (MR) imaging of hepatic neuroendocrine tumors (hNET) and to identify the features that differentiate secondary from primary tumors. METHODS: This retrospective study was approved by the institutional review board, and the requirement for informed consent was waived. Between August 2008 and December 2014, 50 patients with pathologically proven hNETs who underwent gadoxetic acid-enhanced MR imaging with diffusion-weighted images were included...
June 1, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29857864/percutaneous-vertebroplasty-in-tumoral-spinal-fractures-with-posterior-vertebral-wall-involvement-feasibility-and-safety
#17
Nicolas Amoretti, Palominos Diego, Pellegrin Amélie, Olivier Andreani, Pauline Foti, Heidy Schmid-Antomarchi, Jean-Claude Scimeca, Pascal Boileau
PURPOSE: to evaluate the technical feasibility and safety of CT and fluoroscopy guided percutaneous vertebroplasty in the treatment of tumoral vertebral fractures with posterior wall involvement. MATERIALS AND METHODS: Institutional review board approval and informed consent were obtained for this study. Sixty-three consecutive adult patients (35 women, 28 men; mean age+/- standard deviation: 69 years+/- 14) with tumoral spinal fractures that compromised the posterior wall were treated by means of percutaneous vertebroplasty with CT and fluoroscopy guidance...
July 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29846201/corr%C3%A2-tumor-board-micrometastatic-drug-screening-platform-shows-heterogeneous-response-to-map-chemotherapy-in-osteosarcoma-cell-lines
#18
Megan E Anderson, Jim S Wu, Sara O Vargas
No abstract text is available yet for this article.
May 24, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29808697/-a-development-and-overview-of-the-use-of-chemotherapy-and-the-role-of-radiotherapy-and-surgery-in-patients-with-newly-diagnosed-pancreatic-tumor-and-cancer-in-the-current-5-year-center-practice
#19
S Vokurka, M Votavová, J Kulhánková, H Korunková, O Fiala, K Štěrbová, T Svoboda, R Vojtíšek, V M Matějka, J Fínek
BACKGROUND: Chemotherapy (CHT), surgery and radiotherapy (RT) are essential modalities in the treatment of pancreatic malignancies. Their use in practice may be influenced by a number of factors. PATIENTS AND METHODS: Retrospective analysis of CHT, surgery and RT indications and CHT results in patients reported with pancreatic tumor in Pilsen in 2012-2016. RESULTS: A total of 348 patients with median age 68 (19-89) years with newly diagnosed pancreatic tumor, resp...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29808696/-dysregulation-of-long-non-coding-rnas-in-glioblastoma-multiforme-and-their-study-through-use-of-modern-molecular-genetic-approaches
#20
M Večeřa, J Šána, R Bútová, Š Reguli, M Hermanová, L Křen, R Lipina, M Smrčka, O Slabý
BACKGROUND: Glioblastoma (GBM) is the most frequent primary brain tumor characterized by an unfavourable prognosis despite multimodal therapy. Therefore, a lot of efforts and financial resources are dedicated to the research of new therapeutic targets and prognostic or predictive biomarkers. Long non-coding RNAs (lncRNAs) are regulators of gene expression which play a significant role in GBM pathology and, thus, present promising candidates. MATERIAL AND METHODS: Our study included 14 patients with GBM and 8 patients with intractable epilepsy from whom we acquired brain tissues during surgical intervention...
2018: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
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