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https://www.readbyqxmd.com/read/29230668/regional-specificity-of-1p-19q-co-deletion-combined-with-radiological-features-for-predicting-the-survival-outcomes-of-anaplastic-oligodendroglial-tumor-patients
#1
Kai Wang, Yinyan Wang, Xing Fan, Yanong Li, Xing Liu, Jiangfei Wang, Lin Ai, Jianping Dai, Tao Jiang
In this study we aimed to identify the anatomic features of 1p/19q co-deletion and investigate the predictive values of tumor location and radiological characteristics for the survival of anaplastic oligodendroglial (AO) glioma patients. Voxel-based lesion-symptom mapping (VLSM) analysis was applied to define the brain regions associated with occurrence of 1p/19q co-deletion in a cohort of 206 AO tumor patients (discovery set) treated between May 2009 and September 2013. Retrospectively, the acquired clusters and radiological features were subjected to Kaplan-Meier survival analysis using data from the Chinese Glioma Genome Atlas (validation set) to evaluate their prognostic role in AO patients...
December 11, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29228343/long-term-outcome-following-stereotactic-radiosurgery-for-glomus-jugulare-tumors-a-single-institution-experience-of-20-years
#2
Mayur Sharma, Antonio Meola, Sushma Bellamkonda, Xuefei Jia, Joshua Montgomery, Samuel T Chao, John H Suh, Lilyana Angelov, Gene H Barnett
BACKGROUND: Glomus jugulare tumors (GJTs) are rare benign tumors, which pose significant treatment challenges due to proximity to critical structures. OBJECTIVE: To evaluate the long-term clinical and radiological outcome in patients undergoing stereotactic radiosurgery (SRS) for GJTs through retrospective study. METHODS: Forty-two patients with 43 GJTs were treated using Gamma Knife radiosurgery (GKRS; Elekta AB, Stockholm, Sweden) at our institute from 1997 to 2016...
December 4, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29215535/the-clinicopathological-aspects-of-primary-presacral-neuroendocrine-neoplasms-one-center-experience
#3
Guoqing Yang, Deepti Dhall, Run Yu, Richard Tuli, Farin F Amersi, Marc L Friedman, Nicholas N Nissen, Andrew E Hendifar
OBJECTIVES: Presacral neuroendocrine neoplasms (NENs) are rare entities that are found at the presacral space. We report our experience in the diagnosis, management, and outcomes of primary presacral NENs. METHODS: This was an institutional review board-approved retrospective review of medical records and surgical pathology specimens of patients with a diagnosis of NENs at Cedars-Sinai Medical Center between January 2000 and April 2016. RESULTS: Ten patients were identified...
December 5, 2017: Pancreas
https://www.readbyqxmd.com/read/29207685/excellent-response-to-chemotherapy-post-immunotherapy
#4
Ashish D Dwary, Samip Master, Abhishek Patel, Constance Cole, Richard Mansour, Glenn Mills, Nebu Koshy, Prakash Peddi, Gary Burton, Dalia Hammoud, Kavitha Beedupalli
Introduction: Immunotherapy in the form of immune checkpoint inhibitors has changed the landscape of cancer treatment. Newer monoclonal antibodies are coming up and are being tested in various cancers during different stages of treatment. With the increasing use of immune checkpoint inhibitors in the management of various types of cancers, the question is raised as to what next can be offered to a patient who has progressed on this newer treatment. Does Sequence matter? There have been reports of improved responses to chemotherapy after immunotherapy in the form of vaccines...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29206595/assessment-of-response-to-transcatheter-arterial-chemoembolization-with-doxorubicin-eluting-microspheres-tumor-biology-and-hepatocellular-carcinoma-recurrence-in-a-5-year-transplant-cohort
#5
Tyler A Sandow, Stephen E Arndt, Abeer A Albar, Daniel A DeVun, David S Kirsch, Juan M Gimenez, Humberto E Bohorquez, Patrick J Gilbert, Paul T Thevenot, Kelley G Nunez, Gretchen A Galliano, Ari J Cohen, Dennis Kay, Paul M Gulotta
Purpose To assess response to transcatheter arterial chemoembolization (TACE) based on immune markers and tumor biology in patients with hepatocellular carcinoma (HCC) who were bridged to liver transplantation, and to produce an optimized pretransplantation model for posttransplantation recurrence risk. Materials and Methods In this institutional review board-approved HIPAA-compliant retrospective analysis, 93 consecutive patients (73 male, 20 female; mean age, 59.6 years; age range, 23-72 years) underwent TACE with doxorubicin-eluting microspheres (DEB) (hereafter, DEB-TACE) and subsequently underwent transplantation over a 5-year period from July 7, 2011, to May 16, 2016...
December 4, 2017: Radiology
https://www.readbyqxmd.com/read/29205634/safety-and-feasibility-of-stereotactic-radiotherapy-using-computed-portal-radiography-for-canine-intracranial-tumors
#6
Nicholas J Rancilio, R Timothy Bentley, Jeannie Poulson Plantenga, Magdalena M Parys, Beatriz G Crespo, George E Moore
Stereotactic radiotherapy is a highly conformal treatment option for intracranial and extracranial malignancies. Stereotactic radiotherapy utilizes specialized equipment specifically designed to avoid normal tissue while delivering ablative treatments with submillimeter precision and accuracy. Linear accelerator based stereotactic radiotherapy incorporates on-board image guidance utilizing cone beam computed tomography (CT). Many institutions lack the ability to provide image guidance with cone beam CT but delivery of highly conformal treatments with submillimeter precision and accuracy is still feasible...
December 4, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29204522/single-fraction-stereotactic-radiosurgery-for-multiple-brain-metastases
#7
Dror Limon, Frances McSherry, James Herndon, John Sampson, Peter Fecci, Justus Adamson, Zhiheng Wang, Fang-Fang Yin, Scott Floyd, John Kirkpatrick, Grace J Kim
Introduction: Due to the neurocognitive side effects of whole brain radiation therapy (WBRT), stereotactic radiosurgery (SRS) is being used with increasing frequency. The use of SRS is expanding for patients with multiple (>4) brain metastases (BM). This study summarizes our institutional experience with single-fraction, linear-accelerator-based SRS for multiple BM. Methods and materials: All patients who were treated between January 1, 2013, and September 30, 2015, with single-fraction SRS for ≥4 BM were included in this institutional review board-approved, retrospective, single-institution study...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29203975/a-prospective-study-of-distal-microscopic-spread-in-rectal-cancer-after-neoadjuvant-chemoradiation-in-pinned-and-unpinned-specimen
#8
Aravind S Kapali, K Chandramohan, A V Jayasudha
The most important margin in determining the prognosis of rectal cancer is circumferential resection margin (CRM). But, the type of surgery is determined by distal rectal margin (DRM), whether sphincter saving procedure is possible or patient needs an abdominoperineal resection. There are no standardized uniform guidelines for measurement of DRM. The purpose of this study is to assess the distal microscopic spread beyond gross margin after neoadjuvant concurrent chemoradiation (CCRT) in rectal cancers, the factors influencing the distal microscopic spread, the shrinkage of the distal margin in pinned and unpinned fresh and fixed specimen, and to find out the best method of measurement of distal rectal margin...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29203694/path-toward-precision-oncology-review-of-targeted-therapy-studies-and-tools-to-aid-in-defining-actionability-of-a-molecular-lesion-and-patient-management-support
#9
REVIEW
Young Kwang Chae, Alan P Pan, Andrew A Davis, Sandip P Patel, Benedito A Carneiro, Razelle Kurzrock, Francis J Giles
Precision medicine trials and targeted therapies have shifted to the forefront of oncology. Although targeted therapies have shown initial promise, implementation across the broad landscape of oncology has many challenges. These limitations include an incomplete understanding of the functional significance of variant alleles as well as the need for clinical research and practice models that are more patient-centered and account for the complexity of individual patient tumors. Furthermore, successful implementation of targeted therapies will also be predicated on efforts to standardize the framework for patient management support...
December 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29201453/the-role-of-multimodal-treatment-in-patients-with-advanced-lung-neuroendocrine-tumors
#10
REVIEW
Nicola Fazio, Antonio Ungaro, Francesca Spada, Chiara Alessandra Cella, Eleonora Pisa, Massimo Barberis, Chiara Grana, Dario Zerini, Emilio Bertani, Dario Ribero, Luigi Funicelli, Guido Bonomo, Davide Ravizza, Juliana Guarize, Filippo De Marinis, Francesco Petrella, Ester Del Signore, Giuseppe Pelosi, Lorenzo Spaggiari
Lung neuroendocrine tumors (NETs) comprise typical (TC) and atypical carcinoids (AC). They represent the well differentiated (WD) or low/intermediate grade forms of lung neuroendocrine neoplasms (NENs). Unlike the lung poorly differentiated NENs, that are usually treated with chemotherapy, lung NETs can be managed with several different therapies, making a multidisciplinary interaction a key point. We critically discussed the multimodal clinical management of patients with advanced lung NETs. Provided that no therapeutic algorithm has been validate so far, each clinical case should be discussed within a NEN-dedicated multidisciplinary team...
November 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29191245/3-0t-mri-for-long-term-observation-of-lung-nodules-post-cryoablation-a-pilot-study
#11
Jing Li, Jinrong Qu, Hongkai Zhang, Yingshu Wang, Lin Zheng, Xiang Geng, Yan Zhao, Hailiang Li
BACKGROUND: The purpose of this study was to use serial magnetic resonance imaging (MRI) examinations to observe changes in malignant lung tumors over time post-cryoablation. METHODS: The study protocol was approved by Institutional Review Board, and written informed consent was obtained from each participant in accordance with the Declaration of Helsinki. Patients with primary or metastatic lung tumors eligible for cryoablation were included in this prospective study...
December 1, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/29189102/changes-in-signal-intensity-of-the-dentate-nucleus-and-globus-pallidus-in-pediatric-patients-impact-of-brain-irradiation-and-presence-of-primary-brain-tumors-independent-of-linear-gadolinium-based-contrast-agent-administration
#12
Benita Tamrazi, Binh Nguyen, Chia-Shang J Liu, Colleen G Azen, Mary B Nelson, Girish Dhall, Marvin D Nelson
Purpose To determine whether whole-brain irradiation, chemotherapy, and primary brain pathologic conditions affect magnetic resonance (MR) imaging signal changes in pediatric patients independent of the administration of gadolinium-based contrast agents (GBCAs). Materials and Methods This institutional review board-approved, HIPAA-compliant study included 144 pediatric patients who underwent intravenous GBCA-enhanced MR imaging examinations (55 patients with primary brain tumors and whole-brain irradiation, 19 with primary brain tumors and chemotherapy only, 52 with primary brain tumors without any treatment, and 18 with neuroblastoma without brain metastatic disease)...
November 30, 2017: Radiology
https://www.readbyqxmd.com/read/29184467/the-perfect-total-mesorectal-excision-obviates-the-need-for-anything-else-in-the-management-of-most-rectal-cancers
#13
REVIEW
Richard John Heald, Ines Santiago, Oriol Pares, Carlos Carvalho, Nuno Figueiredo
This article discusses the local control of primary rectal cancer and its locoregional spread in the light of modern advances. In recent years, the use of neoadjuvant chemoradiation has spread widely. However, its true benefit is not always balanced with its morbidities. Often total mesorectal excision (TME) is the best option. We will discuss the indications for immediate surgery for chemoradiation in advance and the importance of a delay in the management plan. To understand this selection, it is mandatory to know the true extent of tissue at risk for tumor dissemination and spread...
November 2017: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/29181270/safety-and-accuracy-of-68ga-dotatoc-pet-ct-in-children-and-young-adults-with-solid-tumors
#14
Chenue Abongwa, Sarah Mott, Blanca Schafer, Parren McNeely, Ghada Abusin, Thomas O'Dorisio, Gideon Zamba, M Sue O'Dorisio, Yusuf Menda
68Ga-DOTA-tyr3-Octreotide (68Ga-DOTATOC) PET/CT has been shown to have high accuracy in adults with neuroendocrine tumors, however has not been studied in pediatric patients. This study evaluated the safety and accuracy of 68Ga-DOTATOC PET/CT in children and young adults with solid tumors that express somatostatin receptor type 2. A series of three prospective, IRB approved, clinical trials evaluating safety and efficacy of 68Ga-DOTATOC PET/CT were conducted for subjects aged 6 months to 90 years. This study reports the results for the 26 children and young adults, aged 16 months to 29 years who participated in these trials...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29176867/application-of-non-gaussian-water-diffusional-kurtosis-imaging-in-the-assessment-of-uterine-tumors-a-preliminary-study
#15
Aliou Amadou Dia, Masatoshi Hori, Hiromitsu Onishi, Makoto Sakane, Takashi Ota, Takahiro Tsuboyama, Mitsuaki Tatsumi, Tomoyuki Okuaki, Noriyuki Tomiyama
OBJECTIVES: To evaluate the interobserver reliability and value of diffusional kurtosis imaging (DKI) in the assessment of uterine tumors compared with those of conventional diffusion-weighted imaging (DWI). METHODS: This retrospective study was approved by our institutional review board, which waived the requirement for informed consent. Fifty-eight women (mean age: 55.0 ± 13.6 years; range: 30-89 years) with suspected malignant uterine tumors underwent 3-T magnetic resonance imaging using DKI and DWI...
2017: PloS One
https://www.readbyqxmd.com/read/29168402/liquid-metal-bath-as-conformable-soft-electrodes-for-target-tissue-ablation-in-radio-frequency-ablation-therapy
#16
Xuyang Sun, Zhi-Zhu He, Zhong-Shan Deng, Yi-Xin Zhou, Jing Liu
BACKGROUND: Radio-frequency ablation has been an important physical method for tumor hyperthermia therapy. The conventional rigid electrode boards are often uncomfortable and inconvenient for performing surgery on irregular tumors, especially for those tumors near the joints, such as ankles, knee-joints or other facets like finger joints. MATERIAL AND METHODS: We proposed and demonstrated a highly conformable tumor ablation strategy through introducing liquid metal bath as conformable soft electrodes...
November 23, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/29166539/an-unusual-cause-of-headache-and-sudden-death-of-a-young-sailor-postmortem-computed-tomography-and-histological-findings-of-a-fatal-retroperitoneal-malignant-mixed-germ-cell-tumor
#17
Belinda Lee, Michelle Chan, Ronald Goh
A 26-year-old Caucasian sailor, with no past medical history aside from headache for the last 1 week, was found dead in his cabin. The body was stored in a refrigerator on board and disembarked for autopsy 3 days later. Autopsy showed a large, nodular, necrotic and hemorrhagic retroperitoneal mass, and smaller hemorrhagic nodules in the brain, lungs, liver, and left kidney, with the brain being markedly edematous. Both testes were descended and normal. Histologically, the retroperitoneal mass showed a malignant mixed germ cell tumor comprising choriocarcinoma, embryonal carcinoma, and teratoma components...
November 22, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29166246/imaging-features-of-gadoxetic-acid-enhanced-and-diffusion-weighted-mr-imaging-for-identifying-cytokeratin-19-positive-hepatocellular-carcinoma-a-retrospective-observational-study
#18
Seo-Youn Choi, Seong Hyun Kim, Cheol Keun Park, Ji Hye Min, Ji Eun Lee, Yoon-Hyeong Choi, Bo Ra Lee
Purpose To determine the preoperative magnetic resonance (MR) imaging findings potentially most useful for predicting cytokeratin 19 (CK19)-positive hepatocellular carcinoma (HCC) and to evaluate the prognosis after curative resection in patients with a single HCC lesion positive for CK19 compared with patients with HCC who are negative for CK19. Materials and Methods The institutional review board approved this study and waived the requirement for informed consent. Two hundred four patients with CK19-negative HCC and 38 with CK19-positive HCC who underwent curative resection after gadoxetic acid-enhanced and diffusion-weighted MR imaging were retrospectively evaluated in a single institution...
November 21, 2017: Radiology
https://www.readbyqxmd.com/read/29165809/medical-industry-at-tumor-board-three-years-analysis-of-the-open-payments-database-and-comparison-of-oncologic-specialties
#19
Amanjit S Baadh, Mikin Patel, Ketan Patel, Osman Ahmed
BACKGROUND AND OBJECTIVES: To analyze and contrast medical industry payments across U.S. oncologic providers, including hematology-oncology (HO), surgical oncology (SO), interventional radiology (IR), and radiation oncology (RO). METHODS: Open-payment-data for each provider including provider specialty, state of practice, industry payor, reason for payment, and amount was compiled for each transaction between 2013 and 2015. Total, mean, and median payment amounts per-provider were calculated for each specialty...
November 22, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29165638/feasibility-of-real-time-molecular-profiling-for-patients-with-newly-diagnosed-glioblastoma-without-mgmt-promoter-hypermethylation-the-nct-neuro-master-match-n2m2-pilot-study
#20
Elke Pfaff, Tobias Kessler, Gnana Prakash Balasubramanian, Anne Berberich, Daniel Schrimpf, Antje Wick, Jürgen Debus, Andreas Unterberg, Martin Bendszus, Christel Herold-Mende, David Capper, Irini Schenkel, Andreas Eisenmenger, Susan Dettmer, Benedikt Brors, Michael Platten, Stefan M Pfister, Andreas von Deimling, David T W Jones, Wolfgang Wick, Felix Sahm
Introduction: O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status is a predictive biomarker in glioblastoma patients. Glioblastoma without hypermethylated MGMT promoter are largely resistant to treatment with temozolomide. These patients are in particular need of new treatment approaches, which are offered by biomarker-driven clinical trials with targeted drugs based on molecular characterization of individual tumors. Methods: In preparation for an upcoming clinical study, a comprehensive molecular profiling approach was undertaken on tissues from 43 glioblastoma patients harboring an unmethylated MGMT promoter at diagnosis...
November 18, 2017: Neuro-oncology
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