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https://www.readbyqxmd.com/read/29045506/clinical-and-molecular-characterization-of-patients-with-cancers-of-unknown-primary-in-the-modern-era
#1
A M Varghese, A Arora, M Capanu, N Camacho, H H Won, A Zehir, J Gao, D Chakravarty, N Schultz, D S Klimstra, M Ladanyi, D M Hyman, D B Solit, M F Berger, L B Saltz
Background: On the basis of historical data, patients with cancers of unknown primary (CUP) are generally assumed to have a dismal prognosis with overall survival of less than one year. Treatment is typically cytotoxic chemotherapy guided by histologic features and the pattern of metastatic spread. The purpose of this study was to provide a clinical and pathologic description of patients with CUP in the modern era, to define the frequency of clinically actionable molecular alterations in this population, to determine how molecular testing can alter therapeutic decisions, and to investigate novel uses of next generation sequencing in the evaluation and treatment of patients with CUP...
September 26, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29045504/molecular-tumor-boards-current-practice-and-future-needs
#2
D L van der Velden, C M L van Herpen, H W M van Laarhoven, E F Smit, H J M Groen, S M Willems, P M Nederlof, M H G Langenberg, E Cuppen, S Sleijfer, N Steeghs, E E Voest
Background: due to rapid technical advances, steeply declining sequencing costs, and the ever-increasing number of targeted therapies, it can be expected that extensive tumor sequencing such as Whole Exome- and -Genome Sequencing will soon be applied in standard care. Clinicians will thus be confronted with increasingly complex genetic information and multiple test-platforms to choose from. General medical training, meanwhile, can hardly keep up with the pace of innovation. Consequently, there is a rapidly growing gap between clinical knowledge and genetic potential in cancer care...
September 27, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29044908/tumor-radiomic-heterogeneity-multiparametric-functional-imaging-to-characterize-variability-and-predict-response-following-cervical-cancer-radiation-therapy
#3
Stephen R Bowen, William T C Yuh, Daniel S Hippe, Wei Wu, Savannah C Partridge, Saba Elias, Guang Jia, Zhibin Huang, George A Sandison, Dennis Nelson, Michael V Knopp, Simon S Lo, Paul E Kinahan, Nina A Mayr
BACKGROUND: Robust approaches to quantify tumor heterogeneity are needed to provide early decision support for precise individualized therapy. PURPOSE: To conduct a technical exploration of longitudinal changes in tumor heterogeneity patterns on dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI) and FDG positron emission tomography / computed tomography (PET/CT), and their association to radiation therapy (RT) response in cervical cancer...
October 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29042395/nuclear-receptor-profiling-in-prostatospheroids-and-castration-resistant-prostate-cancer
#4
Zhu Wang, Dinglan Wu, Chi-Fai Ng, Jeremy Yuen-Chun Teoh, Shan Yu, Yuliang Wang, Franky Leung Chan
Nuclear receptors (NRs), which belong to a superfamily of transcription factors and consist of a total of 48 members in humans, govern the expression of genes involved in a board range of developmental, reproductive, metabolic and immunological programs. Given the significant importance of androgen receptor and a few known NRs in the progression of prostate cancer, we surveyed the expression profiles of the entire NR superfamily in three-dimensional (3D) cultured prostatospheroids derived from different prostate cancer cell lines and a tumor xenograft model of castration-resistant prostate cancer VCaP-CRPC by quantitative real-time RT-PCR...
October 17, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29042120/pilot-study-on-the-impact-of-f18-labeled-thymidine-pet-ct-on-gross-tumor-volume-identification-and-definition-for-pancreatic-cancer
#5
Jennifer L Pretz, Michael A Blake, Joseph H Killoran, Harvey J Mamon, Jennifer Y Wo, Andrew X Zhu, Theodore S Hong
PURPOSE: Accurate target definition for radiation therapy planning in localized pancreatic cancer is critical, particularly when using strategies that omit elective coverage. Standard imaging modalities such as computed tomography (CT), magnetic resonance imaging, and endoscopic ultrasound have limited concordance with pathologic evaluation. Biologic imaging with [F18]-fluorodeoxyglucose (FDG)-positron emission tomography (PET) can also be difficult to interpret because increased activity is indicative of increased glucose metabolism, rather than cellular proliferation...
September 18, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29040119/prospective-clinical-trial-of-corneal-reconstruction-with-biomaterial-free-cultured-oral-mucosal-epithelial-cell-sheets
#6
Yu Jeong Kim, Hyun Ju Lee, Jin Suk Ryu, Yun Hee Kim, Saewha Jeon, Joo Youn Oh, Ho Kyung Choung, Sang In Khwarg, Won Ryang Wee, Mee Kum Kim
PURPOSE: To investigate the efficacy and safety of transplantation with biomaterial-free cultured oral mucosal epithelial cell sheets (COMECs) for ocular reconstruction in subjects with total limbal stem cell deficiency. METHODS: A prospective clinical trial (NCT02149732) was conducted in 8 subjects with total limbal stem cell deficiency after approval from the institutional review board of Seoul National University Hospital (H-0707-043-213) and the Ministry of Food and Drug Safety of Korea...
October 13, 2017: Cornea
https://www.readbyqxmd.com/read/29039744/implementing-a-multidisciplinary-tumor-board-in-the-community-practice-setting
#7
Michele Lesslie, Jay R Parikh
Multidisciplinary tumor boards are an opportunity for radiologists to demonstrate value to referring clinicians, the hospital, and patients. Multidisciplinary tumor boards are commonly utilized in academic institutions, but may not be readily available in community practice. We discuss strategies academic radiologists may employ to assist in the implementation of a multidisciplinary tumor board in the community practice setting. SUMMARY: Strategies to assist in the implementation of a multidisciplinary tumor board in the community practice setting are described...
October 17, 2017: Diagnostics
https://www.readbyqxmd.com/read/29031037/-evaluation-of-anti-cancer-therapies-with-reimbursement-limited-to-comprehensive-cancer-centres-using-the-european-society-for-medical-oncology-magnitude-of-clinical-benefit-scale
#8
T Büchler, B Melichar, D Vrána, R Lemstrová, J Fínek, L Dušek, K Petráková, J Prausová
BACKGROUND: The costs of oncology treatments are increasing, due to the rising prevalence of malignant diseases and the introduction of expensive novel anti-cancer agents. The new European Society for Clinical Oncology (ESMO) has recently developed a new parametric system to evaluate the clinical benefit of drugs. The Magnitude of Clinical Benefit Scale (ESMO-MCBS) compares the contribution of a novel drug based on overall and progression-free survival and quality of life with those of current treatment options...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29031036/-the-role-of-chemotherapy-in-the-treatment-of-low-grade-gliomas
#9
R Lakomý, T Kazda, A Poprach, P Pospíšil, R Jančálek, P Šlampa
BACKGROUND: The standard postsurgical options for low-grade gliomas include watchful waiting or radiotherapy depending on the risk factors for recurrence. The use of chemotherapy for the treatment of this disease is generally controversial, although the recently published results of the first of two large randomized phase III clinical trials (RTOG 9802 a EORTC 22033-26033), focusing on the evaluation of chemotherapy for the upfront treatment of newly diagnosed low-grade gliomas, are reassuring in this respect...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29031035/-controversy-in-the-postoperative-treatment-of-low-grade-gliomas
#10
T Kazda, R Lakomý, A Poprach, P Pospíšil, R Jančálek, P Šlampa
BACKGROUND: The optimal treatment for low-grade gliomas remains controversial. Neurosurgery, radiotherapy, and chemotherapy are the main treatment options. Despite advances in oncology, there are still a lot of uncertainties, and the optimal sequences, combinations, and timings of these procedures have not yet been optimized. It is still unclear whether temozolomide can replace effective, but toxic PCV chemotherapy (procarbazine, lomustine, vincristine) and whether temozolomide can be used upfront alone instead of radiotherapy alone...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29031034/-potential-of-using-vitamin-d-as-an-adjuvant-treatment-of-malignant-melanoma
#11
B Bolerázska, E Ďurovcová, M Mareková
The incidence of malignant melanoma worldwide continues to grow despite the enormous advances in topical and systemic therapy. This increase is recorded regularly even in countries where, as a result of public health campaigns, dermatological examination and subsequent treatment have become more frequent. However, there have been reports of a stable or even decreasing mortality rate that seem to contradict the objective increase in its incidence. The well-known risk factors for malignant melanoma include sunburns and occasional sunbathing, whereas regular sunbathing is associated with a lower incidence...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/29025723/setting-the-stage-for-2018-how-the-changes-in-the-american-joint-committee-on-cancer-union-for-international-cancer-control-cancer-staging-manual-eighth-edition-impact-radiologists
#12
C M Glastonbury, S K Mukherji, B O'Sullivan, W M Lydiatt
The updated eighth edition of the Cancer Staging Manual of the American Joint Committee on Cancer will be implemented in January 2018. There are multiple changes to the head and neck section of the manual, which will be relevant to radiologists participating in multidisciplinary head and neck tumor boards and reading pretreatment head and neck cancer scans. Human papillomavirus-related/p16(+) oropharyngeal squamous cell carcinoma will now be staged separately; this change reflects the markedly better prognosis of these tumors compared with non-human papillomavirus/p16(-) oropharyngeal squamous cell carcinoma...
October 12, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28987669/histogram-analysis-of-diffusion-kurtosis-imaging-estimates-for-in-vivo-assessment-of-2016-who-glioma-grades-a-cross-sectional-observational-study
#13
Johann-Martin Hempel, Jens Schittenhelm, Cornelia Brendle, Benjamin Bender, Georg Bier, Marco Skardelly, Ghazaleh Tabatabai, Salvador Castaneda Vega, Ulrike Ernemann, Uwe Klose
PURPOSE: To assess the diagnostic performance of histogram analysis of diffusion kurtosis imaging (DKI) maps for in vivo assessment of the 2016 World Health Organization Classification of Tumors of the Central Nervous System (2016 CNS WHO) integrated glioma grades. MATERIALS AND METHODS: Seventy-seven patients with histopathologically-confirmed glioma who provided written informed consent were retrospectively assessed between 01/2014 and 03/2017 from a prospective trial approved by the local institutional review board...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28987193/brain-tumors-other-treatment-modalities
#14
Andreas Peyrl, Josa Frischer, Johannes A Hainfellner, Matthias Preusser, Karin Dieckmann, Christine Marosi
Management of tumors of the central nervous system is challenging for clinicians for various reasons, including complex diagnostic procedures, limited penetration of drugs into brain tissue, and the prerequisite to preserve brain function in any case of therapeutic intervention. Therapeutic success is dependent on the efforts, skills, and cooperation of involved specialists and disciplines. Knowledge and ability to apply adequate therapeutic modalities in an interdisciplinary approach in due time are crucial, necessitating coordination of diagnostic procedures and therapeutic interventions by means of multidisciplinary brain tumor boards...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28981400/clinical-outcomes-of-radiofrequency-ablation-for-early-hypovascular-hcc-a-multicenter-retrospective-study
#15
Dong Ho Lee, Jeong Min Lee, Tae Wook Kang, Hyunchul Rhim, So Yeon Kim, Yong Moon Shin, Jung Wook Seo, Moon Hyung Choi, Kyung Bun Lee
Purpose To retrospectively evaluate the clinical outcomes of radiofrequency ablation (RFA) for early hypovascular hepatocellular carcinomas (HCCs) and to compare them with those of typical hypervascular HCCs. Materials and Methods This retrospective multicenter study received institutional review board approval, with a waiver of the need to obtain informed consent. A total of 56 patients (male-to-female ratio, 40:16; mean age, 61.8 years; age range, 33-87 years) with pathologically proven early HCCs that did not meet the noninvasive diagnosis criteria and who were initially treated with RFA at one of five university-affiliated hospitals between January 2009 and December 2013 comprised the study group...
October 5, 2017: Radiology
https://www.readbyqxmd.com/read/28980886/features-from-computerized-texture-analysis-of-breast-cancers-at-pretreatment-mr-imaging-are-associated-with-response-to-neoadjuvant-chemotherapy
#16
Foucauld Chamming's, Yoshiko Ueno, Romuald Ferré, Ellen Kao, Anne-Sophie Jannot, Jaron Chong, Atilla Omeroglu, Benoît Mesurolle, Caroline Reinhold, Benoit Gallix
Purpose To evaluate whether features from texture analysis of breast cancers were associated with pathologic complete response (pCR) after neoadjuvant chemotherapy and to explore the association between texture features and tumor subtypes at pretreatment magnetic resonance (MR) imaging. Materials and Methods Institutional review board approval was obtained. This retrospective study included 85 patients with 85 breast cancers who underwent breast MR imaging before neoadjuvant chemotherapy between April 10, 2008, and March 12, 2015...
October 4, 2017: Radiology
https://www.readbyqxmd.com/read/28979315/development-of-dota-rituximab-to-be-labeled-with-90-y-for-radioimmunotherapy-of-b-cell-non-hodgkin-lymphoma
#17
Fariba Johari Doha, Siyavash Rahmani, Pedram Rikhtechi, Samira Rasaneh, Zahra Sheikholislam, Soraya Shahhosseini
NHL is the most common hematologic cancer in adults. Rituximab is the FDA approved treatment of relapsed or refractory low grade B-cell Non-Hodgkin Lymphoma (NHL). But patients eventually become resistant to rituximab. Since lymphocytes and lymphoma cells are highly radiosensitive, low grade NHL that has relapsed or refractory to standard therapy is treated by RIT in which a beta-emitting radionuclide coupled to anti-CD20 antibody. The association of beta emitter radionuclide to rituximab enhances its therapeutic efficacy...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28971783/improving-the-quality-of-operative-reports-for-transurethral-resection-of-bladder-tumor-surgery-in-resident-education
#18
Joseph Haddad, Christopher Anderson, Jonathan Heinlen, Kelly Stratton, Adamantios Mellis, Harry Herr, Michael Cookson, Sanjay Patel
INTRODUCTION: To assess the quality of resident dictations for transurethral resection of bladder tumor (TURBT). One indicator of surgical quality is the completeness of the operative report. Surprisingly, there is a paucity of standardized operative templates for TURBT and little formalized instruction for learners. The quality of TURBT dictations was assessed and areas of improvement were determined after implementation of a 10 item TURBT checklist. MATERIALS AND METHODS: A retrospective review of the last 50 TURBT operative reports dictated by residents was performed...
October 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28967559/expanding-the-criteria-for-nipple-sparing-mastectomy-in-patients-with-poor-prognostic-features
#19
Priya Jadeja, Richard Ha, Christine Rohde, Jeffrey Ascherman, Robert Grant, Christine Chin, Eileen Connolly, Kevin Kalinsky, Sheldon Feldman, Bret Taback
BACKGROUND: In this study we aimed to review the outcomes of nipple-sparing mastectomy (NSM) in the setting of expanded criteria: previous breast surgery/irradiation, neoadjuvant chemotherapy (NAC), post-NSM irradiation, and to assess conversion to acceptable criteria after NAC. PATIENTS AND METHODS: In this single-institution institutional review board-approved retrospective review, we identified patients who underwent NSM after previous breast intervention or NAC from January 2010 to February 2017...
August 24, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28962578/intraoperative-5-aminolevulinic-acid-induced-photodynamic-diagnosis-of-metastatic-brain-tumors-with-histopathological-analysis
#20
R Yagi, S Kawabata, N Ikeda, N Nonoguchi, M Furuse, Y Katayama, Y Kajimoto, T Kuroiwa
BACKGROUND: Fluorescence-guided surgery using 5-aminolevulinic acid (5-ALA) is a promising real-time navigation method in the surgical resection of malignant gliomas. In order to determine whether this method is applicable to metastatic brain tumors, we evaluated the usefulness of intraoperative fluorescence patterns and histopathological features in patients with metastatic brain tumors. METHODS: We retrospectively reviewed the cases of 16 patients with metastatic brain tumors who underwent intraoperative 5-ALA fluorescence-guided resection...
September 29, 2017: World Journal of Surgical Oncology
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