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https://www.readbyqxmd.com/read/29438424/vestibular-schwannomas-accuracy-of-tumor-volume-estimated-by-ice-cream-cone-formula-using-thin-sliced-mr-images
#1
Hsing-Hao Ho, Ya-Hui Li, Jih-Chin Lee, Chih-Wei Wang, Yi-Lin Yu, Dueng-Yuan Hueng, Hsin-I Ma, Hsian-He Hsu, Chun-Jung Juan
PURPOSE: We estimated the volume of vestibular schwannomas by an ice cream cone formula using thin-sliced magnetic resonance images (MRI) and compared the estimation accuracy among different estimating formulas and between different models. METHODS: The study was approved by a local institutional review board. A total of 100 patients with vestibular schwannomas examined by MRI between January 2011 and November 2015 were enrolled retrospectively. Informed consent was waived...
2018: PloS One
https://www.readbyqxmd.com/read/29435855/the-clinical-impact-of-molecular-breast-imaging-in-women-with-proven-invasive-breast-cancer-scheduled-for-breast-conserving-surgery
#2
Angela Collarino, Renato A Valdés Olmos, Lotta G A J van Berkel, Peter A Neijenhuis, Lidy M H Wijers, Frederik Smit, Lioe-Fee de Geus-Oei, Lenka M Pereira Arias-Bouda
PURPOSE: To investigate the clinical utility of molecular breast imaging (MBI) in patients with proven invasive breast cancer scheduled for breast-conserving surgery (BCS). METHODS: Following approval by the institutional review board and written informed consent, records of patients with newly diagnosed breast cancer scheduled for BCS who had undergone MBI for local staging in the period from March 2012 till December 2014 were retrospectively reviewed. RESULTS: A total of 287 women (aged 30-88 years) were evaluated...
February 13, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29434964/lymph-node-retrieval-after-dissolution-of-surrounding-adipose-tissue-for-pathological-examination-of-colorectal-cancer
#3
Hiromichi Maeda, Ken Okamoto, Koji Oba, Mai Shiga, Yuki Fujieda, Tsutomu Namikawa, Makoto Hiroi, Ichiro Murakami, Kazuhiro Hanazaki, Michiya Kobayashi
Examination of >12 lymph nodes (LNs) is important for the diagnostic accuracy of nodal status following resection of colorectal cancer. In the present study, the efficacy of a fat dissolution technique for LN retrieval was evaluated using resected colon and rectum mesentery. First, the resected mesentery was searched for LNs by inspection and palpation immediately after surgery. Subsequently, fat dissolution liquid was applied to the remnant fat and the LN search was repeated. The primary endpoint was whether the second assessment would increase the number of evaluated LNs...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29429890/response-evaluation-of-giant-cell-tumor-of-bone-treated-by-denosumab-histogram-and-texture-analysis-of-ct-images
#4
Jisook Yi, Young Han Lee, Sang Kyum Kim, Seung Hyun Kim, Ho-Taek Song, Kyoo-Ho Shin, Jin-Suck Suh
BACKGROUND: This study aimed to compare computed tomography (CT) features, including tumor size and textural and histogram measurements, of giant-cell tumors of bone (GCTBs) before and after denosumab treatment and determine their applicability in monitoring GCTB response to denosumab treatment. METHODS: This retrospective study included eight patients (male, 3; female, 5; mean age, 33.4 years) diagnosed with GCTB, who had received treatment by denosumab and had undergone pre- and post-treatment non-contrast CT between January 2010 and December 2016...
February 8, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29429794/treatment-plan-quality-and-delivery-accuracy-assessments-on-3-imrt-delivery-methods-of-stereotactic-body-radiotherapy-for-spine-tumors
#5
Long Huang, Toufik Djemil, Tingliang Zhuang, Martin Andrews, Samuel T Chao, John H Suh, Ping Xia
Stereotactic body radiotherapy (SBRT) for spine tumors has demonstrated clinical effectiveness. The treatment planning and delivery techniques have evolved from dynamic conformal arc therapy, to fixed gantry angle intensity modulated radiotherapy (IMRT), and most recently to volumetric modulated arc therapy (VMAT). A hybrid-arc (HARC) planning and delivery method combining dynamic conformal arc therapy delivery with a number of equally spaced IMRT beams is proposed. In this study we investigated plan quality, delivery accuracy, and efficiency of 3 delivery techniques: IMRT, HARC, and VMAT...
February 8, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29420589/comparison-of-switching-bipolar-ablation-with-multiple-cooled-wet-electrodes-and-switching-monopolar-ablation-with-separable-clustered-electrode-in-treatment-of-small-hepatocellular-carcinoma-a-randomized-controlled-trial
#6
Won Chang, Jeong Min Lee, Dong Ho Lee, Jeong Hee Yoon, Yoon Jun Kim, Jung Hwan Yoon, Joon Koo Han
OBJECTIVE: A randomized controlled trial was conducted to prospectively compare the therapeutic effectiveness of switching bipolar (SB) radiofrequency ablation (RFA) using cooled-wet electrodes and switching monopolar (SM) RFA using separable clustered (SC) electrodes in patients with hepatocellular carcinomas (HCCs). MATERIALS AND METHODS: This prospective study was approved by our Institutional Review Board. Between April 2014 and January 2015, sixty-nine patients with 74 HCCs were randomly treated with RFA using either internally cooled-wet (ICW) electrodes in SB mode (SB-RFA, n = 36) or SC electrodes in SM mode (SM-RFA, n = 38)...
2018: PloS One
https://www.readbyqxmd.com/read/29419543/evaluation-of-mitf-sox10-mart-1-and-r21-immunostaining-for-the-diagnosis-of-residual-melanoma-in-situ-on-chronically-sun-damaged-skin
#7
Euphemia W Mu, Nicola A Quatrano, Sarah E Yagerman, Desiree Ratner, Shane A Meehan
BACKGROUND: Melanocytic immunostains can assist in margin evaluation of melanoma in situ (MIS) excisions; however, their accuracy and reliability relative to hematoxylin & eosin (H&E) is yet to be determined. OBJECTIVE: The objective of this study was to evaluate the sensitivity, specificity, and concordance of 4 melanocyte-specific immunostains for diagnosing MIS occurring on chronically sun-damaged skin. MATERIALS AND METHODS: Serial permanent sections from representative areas of negative margin and residual tumor were stained using H&E, MITF, MART-1, SOX10, and R21 and examined in a blinded fashion...
February 6, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29417641/role-of-computed-tomography-calculated-intraparenchymal-tumor-volume-in-assessment-of-patients-undergoing-partial-nephrectomy
#8
Raj Vikesh Tiwari, Chia Ming Ho, Hong Hong Huang, Henry Sun Sien Ho, Allen Soon Phang Sim
OBJECTIVES: To determine the complexity of renal masses by using an objective novel imaging parameter (intraparenchymal tumor volume) based on computed tomography scans, to correlate this parameter to perioperative outcomes and to the RENAL nephrometry score. METHODS: After institutional review board approval, 87 patients who underwent partial nephrectomy between 2012 and 2016 at Singapore General Hospital, Singapore, were retrospectively analyzed. Preoperative computed tomography intravenous pyelogram scans were reviewed by a single senior radiologist who calculated the intraparenchymal tumor volume...
February 8, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29417268/retrospective-single-arm-cohort-study-of-patients-with-hepatocellular-adenomas-treated-with-percutaneous-thermal-ablation
#9
Oleg Mironov, Arash Jaberi, Robert Beecroft, John R Kachura
PURPOSE: To assess the safety and efficacy of percutaneous thermal ablation for the treatment of hepatocellular adenomas. MATERIALS AND METHODS: This is an ethics board-approved, single-arm, retrospective, cohort study of patients with pathologically proven hepatocellular adenomas treated with percutaneous thermal ablation at a tertiary referral center from 1999 to 2016. Demographic, procedural, and outcome data were collected and summarized with appropriate measures of central tendency and dispersion...
February 7, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29415717/implementing-large-scale-fast-track-diagnostics-in-a-comprehensive-cancer-center-pre-and-post-measurement-data
#10
W H van Harten, N Goedbloed, A H Boekhout, S Heintzbergen
BACKGROUND: In general, patients with a cancer suspicion visit the hospital multiple times before diagnosis is completed. Using various "operations management" techniques a few fast track diagnostic services were implemented in the Netherlands Cancer Institute (NKI) in 2006. Growing patient numbers and increasing process complexity, led to diminished service levels. To decrease the amount of patient visits and to extend these services beyond the (obvious) breast cancer services, fast track diagnostics is now implemented for all 18 cancer types that present with a frequency of minimally one per week...
February 7, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29395437/centers-of-excellence-or-excellence-networks-the-surgical-challenge-and-quality-issues-in-rare-cancers
#11
S Sandrucci, P Naredi, S Bonvalot
There are several suggestions that centralization of care improves outcome for rare cancers, particularly when optimal treatment requires complex surgery or high-technology radiotherapy equipment. Diagnosis and treatment in reference centers are expected to be more accurate because they benefit from large numbers of cases discussed in a multidisciplinary tumor board with a well-run pathway. However, centralization is sometimes moderately perceived by oncologists as a solution to be endorsed for rare cancer patients; disadvantages of centralization are the need for patients to move and the risk of a longer waiting list, with discomfort and possible negative effects on outcome...
January 30, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29392722/diagnosis-of-small-vestibular-schwannomas-using-constructive-interference-steady-state-sequence
#12
Adam A Liudahl, Andrew B Davis, Danielle S Liudahl, Joan Maley, Bruno Policeni, Marlan R Hansen
OBJECTIVES/HYPOTHESIS: The objectives of this study were to evaluate the diagnostic accuracy of constructive interference steady state (CISS) sequencing compared to gadolinium-enhanced T1 (GdT1) magnetic resonance imaging (MRI) to screen for small vestibular schwannomas (VSs), and to assess the overall diagnostic confidence of neuroradiologists in their ability to accurately diagnose or rule out VSs using CISS imaging compared to a GdT1 MRI STUDY DESIGN: Retrospective chart review. METHODS: Chart review from 2011 to 2015 was performed for VS/benign cerebellopontine angle tumors...
February 2, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29392469/endoscopic-and-surgical-management-of-nonampullary-duodenal-neoplasms
#13
Michael J Bartel, Ruchir Puri, Bhaumik Brahmbhatt, Wei-Chung Chen, Daniel Kim, Roberto C Simons Linares, John A Stauffer, Mauricia A Buchanan, Steven P Bowers, Timothy A Woodward, Michael B Wallace, Massimo Raimondo, Horacio J Asbun
BACKGROUND: Sporadic nonampullary duodenal neoplasms (SNADN) can have malignant potential for which endoscopic and surgical resections are offered. We report combined gastroenterologic and surgical experience for treatment of SNADN, including endoscopic mucosal resection (EMR) and pancreas-preserving partial duodenectomy (PPPD). METHODS: We retrospectively reviewed 121 consecutive patients, who underwent 30 PPPDs and 91 EMRs for mucosal and submucosal SNADN. Decision to undergo EMR or surgical resection was based on expert endoscopist and surgeon discretion including multidisciplinary tumor board review...
February 1, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29388903/in-vivo-pet-assay-of-tumor-glutamine-flux-and-metabolism-in-human-trial-of-18f-2s-4r-4-fluoroglutamine
#14
Mark P S Dunphy, James J Harding, Sriram Venneti, Hanwen Zhang, Eva M Burnazi, Jacqueline Bromberg, Antonio M Omuro, James J Hsieh, Ingo K Mellinghoff, Kevin Staton, Christina Pressl, Bradley J Beattie, Pat B Zanzonico, John F Gerecitano, David P Kelsen, Wolfgang Weber, Serge K Lyashchenko, Hank F Kung, Jason S Lewis
Purpose To assess the clinical safety, pharmacokinetics, and tumor imaging characteristics of fluorine 18-(2S,4R)-4-fluoroglutamine (FGln), a glutamine analog radiologic imaging agent. Materials and Methods This study was approved by the institutional review board and conducted under a U.S. Food and Drug Administration-approved Investigational New Drug application in accordance with the Helsinki Declaration and the Health Insurance Portability and Accountability Act. All patients provided written informed consent...
January 31, 2018: Radiology
https://www.readbyqxmd.com/read/29383713/prognostic-factors-for-soft-tissue-sarcoma-patients-with-lung-metastases-only-who-are-receiving-first-line-chemotherapy-an-exploratory-retrospective-analysis-of-the-european-organization-for-research-and-treatment-of-cancer-soft-tissue-and-bone-sarcoma-group
#15
Lars H Lindner, Saskia Litière, Stefan Sleijfer, Charlotte Benson, Antoine Italiano, Bernd Kasper, Christina Messiou, Hans Gelderblom, Eva Wardelmann, Axel Le Cesne, Jean-Yves Blay, Sandrine Marreaud, Nadia Hindi, Ingrid M E Desar, Alessandro Gronchi, Winette T A van der Graaf
The prognosis of adult soft tissue sarcoma (STS) patients with metastases is generally poor. As little is known about the impact of the involvement of different metastatic sites and the extent of pulmonary lesions on the outcome for patients receiving first-line chemotherapy, we aimed to establish prognostic factors for STS patients with lung metastases only. A retrospective, exploratory analysis was performed on 2913 metastatic STS patients who received first-line chemotherapy. Detailed information from 580 patients who had lung metastases only, was used for prognostic factor analysis...
January 31, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29371992/prediction-of-low-risk-breast-cancer-using-quantitative-dce-mri-and-its-pathological-basis
#16
Tingting Xu, Lin Zhang, Hong Xu, Sifeng Kang, Yali Xu, Xiaoyu Luo, Ting Hua, Guangyu Tang
Purpose: This study aimed to evaluate the difference of mass in dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) characteristics between low-risk and non-low-risk breast cancers and to explore the possible pathological basis. Materials and Methods: Approval from the institutional review board and informed consent were acquired for this study. The MR images of 104 patients with pathologically proven breast cancer (104 lesions) were prospectively analyzed...
December 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/29369753/the-incidental-splenic-mass-at-ct-does-it-need-further-work-up-an-observational-study
#17
Bettina Siewert, Noam Z Millo, Kamaldeep Sahi, Robert G Sheiman, Olga R Brook, Maryellen R M Sun, Robert A Kane
Purpose To evaluate whether an incidentally noted splenic mass at abdominal computed tomography (CT) requires further imaging work-up. Materials and Methods In this institutional review board-approved HIPAA-compliant retrospective study, a search of a CT database was performed for patients with splenic masses at CT examinations of the abdomen and chest from 2002 to 2008. Patients were divided into three groups: group 1, patients with a history of malignancy; group 2, patients with symptoms such as weight loss, fever, or pain related to the left upper quadrant and epigastrium; and group 3, patients with incidental findings...
January 24, 2018: Radiology
https://www.readbyqxmd.com/read/29369751/extent-of-bold-vascular-dysregulation-is-greater-in-diffuse-gliomas-without-isocitrate-dehydrogenase-1-r132h-mutation
#18
Zachary K Englander, Craig I Horenstein, Stephen G Bowden, Daniel S Chow, Marc L Otten, Angela Lignelli, Jeffrey N Bruce, Peter Canoll, Jack Grinband
Purpose To determine the effect that R132H mutation status of diffuse glioma has on extent of vascular dysregulation and extent of residual blood oxygen level-dependent (BOLD) abnormality after surgical resection. Materials and Methods This study was an institutional review board-approved retrospective analysis of an institutional database of patients, and informed consent was waived. From 2010 to 2017, 39 treatment-naïve patients with diffuse glioma underwent preoperative echo-planar imaging and BOLD functional magnetic resonance imaging...
January 24, 2018: Radiology
https://www.readbyqxmd.com/read/29357275/prognostic-value-of-metabolic-and-volumetric-parameters-of-fdg-pet-in-pediatric-osteosarcoma-a-hypothesis-generating-study
#19
Hyung-Jun Im, Yi Zhang, Huiyun Wu, Jianrong Wu, Najat C Daw, Fariba Navid, Barry L Shulkin, Steve Y Cho
Purpose To preliminarily assess the potential prognostic value of various fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) parameters before, during, and after neoadjuvant chemotherapy (NCT). Materials and Methods Thirty-four patients with osteosarcoma were enrolled prospectively from 2008 to 2012 and underwent FDG PET/computed tomography (CT) imaging before (baseline scan), during (interim scan) and after NCT (posttherapy scan). The study was approved by the institutional review board and informed consent was received from patients...
January 19, 2018: Radiology
https://www.readbyqxmd.com/read/29351560/the-correlation-of-background-parenchymal-enhancement-in-the-contralateral-breast-with-patient-and-tumor-characteristics-of-mri-screen-detected-breast-cancers
#20
Suzan Vreemann, Albert Gubern-Mérida, Cristina Borelli, Peter Bult, Nico Karssemeijer, Ritse M Mann
PURPOSE: Higher background parenchymal enhancement (BPE) could be used for stratification of MRI screening programs since it might be related to a higher breast cancer risk. Therefore, the purpose of this study is to correlate BPE to patient and tumor characteristics in women with unilateral MRI-screen detected breast cancer who participated in an intermediate and high risk screening program. As BPE in the affected breast may be difficult to discern from enhancing cancer, we assumed that BPE in the contralateral breast is a representative measure for BPE in women with unilateral breast cancer...
2018: PloS One
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