keyword
MENU ▼
Read by QxMD icon Read
search

Newcomb

keyword
https://www.readbyqxmd.com/read/29453130/charting-the-development-of-cognitive-mapping
#1
Alina Nazareth, Steven M Weisberg, Katherine Margulis, Nora S Newcombe
Developmental research beginning in the 1970s has suggested that children's ability to form cognitive maps reaches adult levels during early adolescence. However, this research has used a variety of testing procedures, often in real-world environments, which have been difficult to share widely across labs and to use to probe components of mapping, individual differences in success, and possible mechanisms of development and reasons for individual variation. In this study, we charted the development of cognitive mapping using a virtual navigation paradigm, Silcton, that allows for testing samples of substantial size in a uniform way and in which adults show marked individual differences in the formation of accurate route representations and/or in route integration...
February 13, 2018: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/29444929/development-and-external-validation-of-prediction-models-for-10-year-survival-of-invasive-breast-cancer-comparison-with-predict-and-cancermath
#2
Solon Karapanagiotis, Paul D P Pharoah, Christopher H Jackson, Paul J Newcombe
PURPOSE: To compare PREDICT and CancerMath, two widely used prognostic models for invasive breast cancer, taking into account their clinical utility. Furthermore, it is unclear whether these models could be improved. Experimental Design: A dataset of 5729 women was used for model development. A Bayesian variable selection algorithm was implemented to stochastically search for important interaction terms among the predictors. The derived models were then compared in three independent datasets (n = 5534)...
February 14, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29439783/geographic-access-to-mammography-facilities-and-frequency-of-mammography-screening
#3
Patricia I Jewett, Ronald E Gangnon, Elena Elkin, John M Hampton, Elizabeth A Jacobs, Kristen Malecki, James LaGro, Polly A Newcomb, Amy Trentham-Dietz
PURPOSE: To assess the association between geographic access to mammography facilities and women's mammography utilization frequency. METHODS: Using data from the population-based 1995-2007 Wisconsin Women's Health study, we used proportional odds and logistic regression to test whether driving times to mammography facilities and the number of mammography facilities within 10 km of women's homes were associated with mammography frequency among women aged 50-74 years and whether associations differed between Rural-Urban Commuting Areas and income and education groups...
February 2018: Annals of Epidemiology
https://www.readbyqxmd.com/read/29434315/association-of-gut-microbial-communities-with-plasma-lipopolysaccharide-binding-protein-lbp-in-premenopausal-women
#4
Jessica S Citronberg, Keith R Curtis, Emily White, Polly A Newcomb, Katherine Newton, Charlotte Atkinson, Xiaoling Song, Johanna W Lampe, Meredith Aj Hullar
The mechanisms by which obesity increases cancer risk are unclear, but some lines of evidence suggest that gut microbial communities (GMC) may contribute to chronic inflammation in obese individuals through raised systemic levels of lipopolysaccharides (LPS). We evaluated associations of the GMC in stool with plasma LPS-binding protein (LBP, a measure of LPS) and C-reactive protein (CRP) concentrations in 110 premenopausal women in the United States. Diet was assessed using 3-day food records and GMCs were evaluated using pyrosequencing of the 16S rRNA gene...
February 12, 2018: ISME Journal
https://www.readbyqxmd.com/read/29433975/refined-analysis-of-prostate-specific-antigen-kinetics-to-predict-prostate-cancer-active-surveillance-outcomes
#5
Matthew R Cooperberg, James D Brooks, Anna V Faino, Lisa F Newcomb, James T Kearns, Peter R Carroll, Atreya Dash, Ruth Etzioni, Michael D Fabrizio, Martin E Gleave, Todd M Morgan, Peter S Nelson, Ian M Thompson, Andrew A Wagner, Daniel W Lin, Yingye Zheng
BACKGROUND: For men on active surveillance for prostate cancer, utility of prostate-specific antigen (PSA) kinetics (PSAk) in predicting pathologic reclassification remains controversial. OBJECTIVE: To develop prediction methods for utilizing serial PSA and evaluate frequency of collection. DESIGN, SETTING, AND PARTICIPANTS: Data were collected from men enrolled in the multicenter Canary Prostate Active Surveillance Study, for whom PSA data were measured and biopsies performed on prespecified schedules...
February 9, 2018: European Urology
https://www.readbyqxmd.com/read/29433973/role-of-surveillance-biopsy-with-no-cancer-as-a-prognostic-marker-for-reclassification-results-from-the-canary-prostate-active-surveillance-study
#6
James T Kearns, Anna V Faino, Lisa F Newcomb, James D Brooks, Peter R Carroll, Atreya Dash, William J Ellis, Michael Fabrizio, Martin E Gleave, Todd M Morgan, Peter S Nelson, Ian M Thompson, Andrew A Wagner, Yingye Zheng, Daniel W Lin
BACKGROUND: Many patients who are on active surveillance (AS) for prostate cancer will have surveillance prostate needle biopsies (PNBs) without any cancer evident. OBJECTIVE: To define the association between negative surveillance PNBs and risk of reclassification on AS. DESIGN, SETTING, AND PARTICIPANTS: All men were enrolled in the Canary Prostate Active Surveillance Study (PASS) between 2008 and 2016. Men were included if they had Gleason ≤3+4 prostate cancer and <34% core involvement ratio at diagnosis...
February 9, 2018: European Urology
https://www.readbyqxmd.com/read/29417425/the-association-between-post-diagnosis-health-behaviors-and-long-term-quality-of-life-in-survivors-of-ductal-carcinoma-in-situ-a-population-based-longitudinal-cohort-study
#7
Vicki Hart, Amy Trentham-Dietz, Amy Berkman, Mayo Fujii, Christopher Veal, John Hampton, Ronald E Gangnon, Polly A Newcomb, Susan C Gilchrist, Brian L Sprague
PURPOSE: Women diagnosed with ductal carcinoma in situ (DCIS) often experience adverse changes in health-related behaviors following diagnosis. The impact of health behaviors on long-term quality of life (QoL) in DCIS survivors has not been investigated. METHODS: We examined the association of post-diagnosis body mass index (BMI), physical activity, alcohol, and smoking with QoL among 1448 DCIS survivors aged 20-74 enrolled in the population-based Wisconsin in situ Cohort from 1997 to 2006...
February 7, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29410216/sex-hormones-gender-and-asthma
#8
REVIEW
Jeffrey A Yung, Hubaida Fuseini, Dawn C Newcomb
No abstract text is available yet for this article.
February 1, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29408275/a-novel-c2-screw-trajectory-preliminary-anatomical-feasibility-and-biomechanical-comparison
#9
NingNing Dou, Jennifer N Lehrman, Anna G U S Newcomb, Brian P Kelly
BACKGROUND: Pedicle screw and translaminar screw fixation in C2 may not be applicable in many patients with anatomical abnormalities or narrow laminar thickness and spinous process height. The objective of the current study was to assess the morphometric and mechanical feasibilities of a novel alternate C2 screw trajectory. METHODS: A novel screw trajectory that pierces the bifid base of C2 is described. Anatomical measures that determine the feasibility of spinous process bifid base (SPB) screw fixation were assessed in 14 cadaver C2 vertebrae...
February 2, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29402693/left-atrial-appendage-exclusion-using-the-atriclip-device-a-case-series
#10
Sarah Page, Jane Hallam, Neelprada Pradhan, Brian Cowie, Tuong Phan, Desmond McGlade, Alex Rosalion, Andrew Newcomb, Michael Yii
BACKGROUND: Atrial fibrillation (AF) affects 1.5-2% of the population and is associated with a five-fold increased lifetime risk of stroke [1]. The left atrial appendage (LAA) is the source of embolic strokes in up to 90% of patients with non-valvular AF with clots in the left atrium [2]. METHODS: We reviewed the clinical notes and echocardiographic findings of 20 patients who underwent open cardiac surgery in which concurrent AtriClip (Atricure Inc, Westchester, Ohio, USA) device insertion was attempted at our institution from July 2013 to February 2015...
December 22, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29389141/romantic-involvement-a-protective-factor-for-psychological-health-in-racially-diverse-young-sexual-minorities
#11
Sarah W Whitton, Christina Dyar, Michael E Newcomb, Brian Mustanski
Sexual minority youth experience elevated rates of internalizing disorders; it is, therefore, important to identify protective factors that decrease risk for psychological distress in this population. In this study, we examined whether involvement in a romantic relationship, a well-established protective factor for mental health among heterosexual adults, is also protective for young sexual minorities. Using eight waves of data provided by a community sample of 248 racially diverse sexual minority youth (ages 16-20 years at baseline), we assessed within-person associations between relationship involvement and psychological distress...
February 1, 2018: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29373972/differential-gene-expression-in-the-evolution-of-sex-pheromone-communication-in-new-zealand-s-endemic-leafroller-moths-of-the-genera-ctenopseustis-and-planotortrix
#12
Alessandro Grapputo, Amali H Thrimawithana, Bernd Steinwender, Richard D Newcomb
BACKGROUND: Sex pheromone communication in moths has attracted the attention of evolutionary biologists due to the vast array of pheromone compounds used, addressing questions of how this diversity arose and how male reception has evolved in step with the female signal. Here we examine the role of changing gene expression in the evolution of mate recognition systems in leafroller moths, particularly focusing on genes involved in the biosynthetic pathways of sex pheromones in female pheromone glands and the peripheral reception repertoire in the antennae of males...
January 26, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29371689/biologically-active-constituents-of-the-secretome-of-human-w8b2-cardiac-stem-cells
#13
Shuai Nie, Xin Wang, Priyadharshini Sivakumaran, Mark M W Chong, Xin Liu, Tara Karnezis, Nadeeka Bandara, Kaloyan Takov, Cameron J Nowell, Stephen Wilcox, Mitch Shambrook, Andrew F Hill, Nicole C Harris, Andrew E Newcomb, Padraig Strappe, Ramin Shayan, Damián Hernández, Jordan Clarke, Eric Hanssen, Sean M Davidson, Gregory J Dusting, Alice Pébay, Joshua W K Ho, Nicholas Williamson, Shiang Y Lim
The benefits of adult stem cells for repair of the heart have been attributed to the repertoire of salutary paracrine activities they appear to exert. We previously isolated human W8B2+ cardiac stem cells (CSCs) and found they powerfully influence cardiomyocytes and endothelial cells to collectively promote cardiac repair and regeneration. Here, the complexity of the W8B2+ CSC secretomes was characterised and examined in more detail. Using ion exchange chromatography to separate soluble proteins based on their net surface charge, the secreted factors responsible for the pro-survival activity of W8B2+ CSCs were found within the low and medium cation fractions...
January 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29363247/a-comparative-analysis-of-the-co-reducing-activities-of-mofe-proteins-containing-the-mo-and-v-nitrogenase-cofactors
#14
Markus Walter Ribbe, Chi Chung Lee, Kazuki Tanifuji, Megan Newcomb, Jasper Liedtke, Yilin Hu
The Mo- and V-nitrogenases are structurally homologous yet catalytically distinct in their abilities to reduce CO to hydrocarbons. Here we report a comparative analysis of the CO-reducing activities of the Mo- and V-nitrogenase cofactors (i.e., the M- and V-clusters) upon insertion of the respective cofactor into the same, cofactor-deficient MoFe protein scaffold. Our data reveal a combined contribution of protein environment and cofactor properties to the reactivity of nitrogenase toward CO, laying a foundation for further mechanistic investigation of the enzymatic CO reduction while suggesting the potential of targeting both the protein scaffold and the cofactor species for nitrogenase-based applications in the future...
January 24, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29357027/longitudinal-study-of-quality-of-life-among-children-with-acute-respiratory-infection-and-cough
#15
Yolanda G Lovie-Toon, Anne B Chang, Peter A Newcombe, Dimitrios Vagenas, Sophie Anderson-James, Benjamin J Drescher, Michael E Otim, Kerry-Ann F O'Grady
PURPOSE: Acute respiratory infections (ARIs), and associated symptoms such as cough, are frequently experienced among children and impose a burden on families (e.g., use of medical resources and time off work/school). However, there are little data on changes in, and predictors of, quality of life (QoL) over the duration of an ARI with cough (ARIwC) episode. We therefore aimed to determine cough-specific QoL and identify its influencing factors among children with ARIwC, at the time of presentation to a pediatric emergency department (ED), and over the following 4 weeks...
January 22, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29352595/axillary-tumour-burden-in-women-with-one-abnormal-node-on-ultrasound-compared-to-women-with-multiple-abnormal-nodes
#16
S Puri, N Sharma, R G Newcombe, M Kaushik, M Al-Attar, S Pascaline, M Hajaj, M G Wallis, B Elsberger, A Goyal
AIM: To determine if the number of abnormal nodes seen on preoperative axillary ultrasound (AUS) is a predictor of the number of positive nodes at histology for women with needle-biopsy-proven positive nodes. MATERIALS AND METHODS: This prospective multicentre cohort study included consecutive patients with early breast cancer who had needle-biopsy-proven positive nodes on AUS and underwent axillary lymph node dissection (ALND) between October 2015 and July 2016...
January 15, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29348551/designable-and-dynamic-single-walled-stiff-nanotubes-assembled-from-sequence-defined-peptoids
#17
Haibao Jin, Yan-Huai Ding, Mingming Wang, Yang Song, Zhihao Liao, Christina J Newcomb, Xuepeng Wu, Xian-Qiong Tang, Zheng Li, Yuehe Lin, Feng Yan, Tengyue Jian, Peng Mu, Chun-Long Chen
Despite recent advances in the assembly of organic nanotubes, conferral of sequence-defined engineering and dynamic response characteristics to the tubules remains a challenge. Here we report a new family of highly designable and dynamic nanotubes assembled from sequence-defined peptoids through a unique "rolling-up and closure of nanosheet" mechanism. During the assembly process, amorphous spherical particles of amphiphilic peptoid oligomers crystallize to form well-defined nanosheets before folding to form single-walled nanotubes...
January 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29341191/working-and-caring-for-a-child-with-chronic-illness-a-review-of-current-literature
#18
A M Kish, P A Newcombe, D M Haslam
BACKGROUND: Advances in medical knowledge have contributed to the increase in the number of children living with some form of long-term chronic illness or condition. As a consequence of these advancements, treatments that are more accessible and easier to administer, usually within a child's home, have been developed. However, this may mean that parents take on greater treatment responsibility and require extra time and energy to meet these tasks, additional to other responsibilities...
January 16, 2018: Child: Care, Health and Development
https://www.readbyqxmd.com/read/29334375/a-small-molecule-inhibitor-of-the-ubiquitin-activating-enzyme-for-cancer-treatment
#19
Marc L Hyer, Michael A Milhollen, Jeff Ciavarri, Paul Fleming, Tary Traore, Darshan Sappal, Jessica Huck, Judy Shi, James Gavin, Jim Brownell, Yu Yang, Bradley Stringer, Robert Griffin, Frank Bruzzese, Teresa Soucy, Jennifer Duffy, Claudia Rabino, Jessica Riceberg, Kara Hoar, Anya Lublinsky, Saurabh Menon, Michael Sintchak, Nancy Bump, Sai M Pulukuri, Steve Langston, Stephen Tirrell, Mike Kuranda, Petter Veiby, John Newcomb, Ping Li, Jing Tao Wu, Josh Powe, Lawrence R Dick, Paul Greenspan, Katherine Galvin, Mark Manfredi, Chris Claiborne, Benjamin S Amidon, Neil F Bence
The ubiquitin-proteasome system (UPS) comprises a network of enzymes that is responsible for maintaining cellular protein homeostasis. The therapeutic potential of this pathway has been validated by the clinical successes of a number of UPS modulators, including proteasome inhibitors and immunomodulatory imide drugs (IMiDs). Here we identified TAK-243 (formerly known as MLN7243) as a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE), the primary mammalian E1 enzyme that regulates the ubiquitin conjugation cascade...
January 15, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29332235/do-diary-studies-cause-behavior-change-an-examination-of-reactivity-in-sexual-risk-and-substance-use-in-young-men-who-have-sex-with-men
#20
Michael E Newcomb, Gregory Swann, David Mohr, Brian Mustanski
Behavioral diaries are frequently used for observing sexual and substance use behaviors, but participating in diary studies may cause behavior change. This study examined change in sexual and substance use behaviors among young men who have sex with men (YMSM) in a two-month diary study compared to control. An analytic sample of 324 YMSM was randomized to receive daily diaries, weekly diaries, or no diaries (control) for 2 months. Half of the diary participants were randomized to receive automated weekly feedback...
January 13, 2018: AIDS and Behavior
keyword
keyword
113410
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"