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https://www.readbyqxmd.com/read/27902535/urinary-cadmium-and-mammographic-density
#1
Scott V Adams, John M Hampton, Amy Trentham-Dietz, Ronald E Gangnon, Martin M Shafer, Polly A Newcomb
No abstract text is available yet for this article.
January 2017: Epidemiology
https://www.readbyqxmd.com/read/27898907/apparent-total-tract-macronutrient-digestibility-fecal-characteristics-and-fecal-fermentative-end-product-concentrations-of-healthy-adult-dogs-fed-bioprocessed-soy-protein
#2
A N Beloshapka, M R C de Godoy, K B Detweiler, M Newcomb, K H Ellegård, G C Fahey, K S Swanson
Animal proteins are commonly used in extruded dog foods. Plant-based proteins have a more consistent nutrient profile than animal sources but may contain antinutritional factors, including trypsin inhibitors and oligosaccharides. Bioprocessed soy protein (SP; HP-300; Hamlet Protein, Inc., Findlay, OH) is a processed soy-based product with low antinutritional factor concentrations and high protein quality. The objective was to evaluate the effects of SP on apparent total tract macronutrient digestibility, fecal characteristics, and fecal fermentative end products...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27893498/wired-to-the-workplace-the-relationship-between-electronic-connectedness-to-work-and-nurse-manager-satisfaction
#3
Candace Gardner, Amy Hailey, Christi Nguyen, Charlsea Prichard, Patricia Newcomb
OBJECTIVE: The aim of this study is to describe the beliefs and behaviors of nurse leaders regarding electronic connectedness with their workplace and workplace support. BACKGROUND: Electronic communication enables leaders' continuous availability to the workplace. This may blur home-work boundaries and contribute to burnout. METHODS: This mixed-methods study surveyed nurses in 6 acute care hospitals in north Texas. A qualitative phase employed focus groups composed of nurses from participating hospitals to validate and enrich data collected in the quantitative phase...
November 23, 2016: Journal of Nursing Administration
https://www.readbyqxmd.com/read/27889277/evaluating-the-four-kallikrein-panel-of-the-4kscore-for-prediction-of-high-grade-prostate-cancer-in-men-in-the-canary-prostate-active-surveillance-study
#4
Daniel W Lin, Lisa F Newcomb, Marshall D Brown, Daniel D Sjoberg, Yan Dong, James D Brooks, Peter R Carroll, Matthew Cooperberg, Atreya Dash, William J Ellis, Michael Fabrizio, Martin E Gleave, Todd M Morgan, Peter S Nelson, Ian M Thompson, Andrew A Wagner, Yingye Zheng
BACKGROUND: Diagnosis of Gleason 6 prostate cancer can leave uncertainty about the presence of undetected aggressive disease. OBJECTIVE: To evaluate the utility of a four kallikrein (4K) panel in predicting the presence of high-grade cancer in men on active surveillance. DESIGN, SETTING, AND PARTICIPANTS: Plasma collected before the first and subsequent surveillance biopsies was assessed for 718 men prospectively enrolled in the multi-institutional Canary PASS trial...
November 23, 2016: European Urology
https://www.readbyqxmd.com/read/27879336/beyond-antimicrobial-resistance-evidence-for-a-distinct-role-of-the-acrd-efflux-pump-in-salmonella-biology
#5
Michelle M C Buckner, Jessica M A Blair, Roberto M La Ragione, Jane Newcombe, Daniel J Dwyer, Alasdair Ivens, Laura J V Piddock
: For over 20 years, bacterial multidrug resistance (MDR) efflux pumps have been studied because of their impact on resistance to antimicrobials. However, critical questions remain, including why produce efflux pumps under non-antimicrobial treatment conditions, and why have multiple pumps if their only purpose is antimicrobial efflux? Salmonella spp. possess five efflux pump families, including the resistance-nodulation-division (RND) efflux pumps. Notably, the RND efflux pump AcrD has a unique substrate profile, distinct from other Salmonella efflux pumps...
November 22, 2016: MBio
https://www.readbyqxmd.com/read/27876115/the-first-digit-law-a-hypothesis-on-its-possible-impact-on-medicine-and-development-aid
#6
Gregor Pollach, Frank Brunkhorst, Mwapatsa Mipando, Felix Namboya, Samson Mndolo, Thomas Luiz
The "first digit law" or "Benford's law" is a mathematical distribution discovered by Simon Newcomb and Frank Benford. It states, that the probability of the leading number d (d∈{1,…,9}) in many natural datasets follows: P (d)=log10 (d+1)-log10 (d)=log10 (1+1/d). It was successfully used through tax authorities and "forensic accounting" in order to detect fraud and other irregularities. Benfords law was almost neglected for its use outside financial accounting. The planning for health care systems in developing countries is extremely dependant on good, valid data...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27869542/treatment-challenge-of-a-non-toxic-cyanobacterium-romeria-elegans-bloom-event-in-a-south-australian-wastewater-treatment-plant-a-case-study
#7
Radisti A Praptiwi, Carlos J Pestana, Emma T Sawade, Nick Swain, Gretchen Schroeder, Gayle Newcombe
A bloom of the non-toxic cyanobacterium Romeria elegans in waste stabilisation ponds within Angaston waste water treatment plant (WWTP) has posed an unprecedented treatment challenge for the local water utility. The water from the stabilisation ponds is chlorinated for safety prior to reuse on nearby farmland. Cyanobacteria concentrations of approximately 1.2×10(6) cells mL(-1) increased the chlorine demand dramatically. Operators continuously increased the disinfectant dose up to 50 mg L(-1) to achieve operational guideline values for combined chlorine (0...
November 21, 2016: Environmental Technology
https://www.readbyqxmd.com/read/27865153/efficient-multi-scale-3d-cnn-with-fully-connected-crf-for-accurate-brain-lesion-segmentation
#8
Konstantinos Kamnitsas, Christian Ledig, Virginia F J Newcombe, Joanna P Simpson, Andrew D Kane, David K Menon, Daniel Rueckert, Ben Glocker
We propose a dual pathway, 11-layers deep, three-dimensional Convolutional Neural Network for the challenging task of brain lesion segmentation. The devised architecture is the result of an in-depth analysis of the limitations of current networks proposed for similar applications. To overcome the computational burden of processing 3D medical scans, we have devised an efficient and effective dense training scheme which joins the processing of adjacent image patches into one pass through the network while automatically adapting to the inherent class imbalance present in the data...
October 29, 2016: Medical Image Analysis
https://www.readbyqxmd.com/read/27864968/taphonomic-effects-of-mechanical-plowing-on-buried-juvenile-sized-remains
#9
Alyssa M Newcomb, James T Pokines, Tara L Moore
Agricultural activity is a worldwide taphonomic process and can present unique challenges in the recovery of buried remains. Previous research has been mostly within the realm of site formation processes of archeological sites utilizing only surface material. This research expands upon the previous research by incorporating the distribution of subsurface material by the use of archeological excavation techniques. An experiment was conducted utilizing juvenile pig (Sus scrofa) skeletons buried in relative anatomical position at two different depths (15 cm below the surface [cmbs] and 22 cmbs)...
November 16, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27862541/paediatrician-beliefs-and-practices-around-influenza-vaccination
#10
James P Newcombe, Rajneesh Kaur, Nicholas Wood, Holly Seale, Pamela Palasanthiran, Thomas L Snelling
AIM: The uptake of influenza vaccination in children with high-risk medical conditions continues to be low in Australia and internationally. We aimed to determine Australian paediatricians' beliefs and practices around the influenza vaccination of children. METHODS: This was conducted as a cross sectional survey of paediatricians from two tertiary paediatric hospitals in Sydney. RESULTS: There were 101 participants. Influenza vaccination was not prioritised compared with other vaccines and clinical issues, with fewer than half of respondents strongly agreeing that influenza vaccination was useful...
November 15, 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27861761/prediagnostic-alcohol-consumption-and-colorectal-cancer-survival-the-colon-cancer-family-registry
#11
Amanda I Phipps, Jamaica R Robinson, Peter T Campbell, Aung Ko Win, Jane C Figueiredo, Noralane M Lindor, Polly A Newcomb
BACKGROUND: Although previous studies have noted an increased risk of colorectal cancer (CRC) among moderate to heavy alcohol consumers in comparison with nondrinkers, the relation between alcohol consumption and CRC survival remains unclear. METHODS: Cases of incident invasive CRC diagnosed between 1997 and 2007 were identified via population-based cancer registries at 4 study sites in the Colon Cancer Family Registry. Study participants completed a risk-factor questionnaire on prediagnostic behaviors, including wine, beer, and liquor consumption, at the baseline...
November 8, 2016: Cancer
https://www.readbyqxmd.com/read/27859228/testing-a-novel-3d-printed-radiographic-imaging-device-for-use-in-forensic-odontology
#12
Tara L Newcomb, Ann M Bruhn, Bridget Giles, Hector M Garcia, Norou Diawara
There are specific challenges related to forensic dental radiology and difficulties in aligning X-ray equipment to teeth of interest. Researchers used 3D printing to create a new device, the combined holding and aiming device (CHAD), to address the positioning limitations of current dental X-ray devices. Participants (N = 24) used the CHAD, soft dental wax, and a modified external aiming device (MEAD) to determine device preference, radiographer's efficiency, and technique errors. Each participant exposed six X-rays per device for a total of 432 X-rays scored...
November 10, 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27846218/muc1-expression-by-immunohistochemistry-is-associated-with-adverse-pathologic-features-in-prostate-cancer-a-multi-institutional-study
#13
Okyaz Eminaga, Wei Wei, Sarah J Hawley, Heidi Auman, Lisa F Newcomb, Jeff Simko, Antonio Hurtado-Coll, Dean A Troyer, Peter R Carroll, Martin E Gleave, Daniel W Lin, Peter S Nelson, Ian M Thompson, Lawrence D True, Jesse K McKenney, Ziding Feng, Ladan Fazli, James D Brooks
BACKGROUND: The uncertainties inherent in clinical measures of prostate cancer (CaP) aggressiveness endorse the investigation of clinically validated tissue biomarkers. MUC1 expression has been previously reported to independently predict aggressive localized prostate cancer. We used a large cohort to validate whether MUC1 protein levels measured by immunohistochemistry (IHC) predict aggressive cancer, recurrence and survival outcomes after radical prostatectomy independent of clinical and pathological parameters...
2016: PloS One
https://www.readbyqxmd.com/read/27826745/a-person-centered-analysis-of-risk-factors-that-compromise-wellbeing-in-emerging-adulthood
#14
Sarah E Newcomb-Anjo, Erin T Barker, Andrea L Howard
The transition to adulthood is a major life course transition that can pose risk to wellbeing. Research is needed to identify patterns of risk for compromised wellbeing, in order to best identify supports for individuals during this potentially vulnerable transition. The purpose of this study was to identify profiles of risk in an emerging adulthood sample, and to relate these profiles to mental health and subjective and academic wellbeing. Undergraduate emerging adults (N = 903, 82 % female), aged 18-25 years (M = 21...
November 8, 2016: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/27825662/talk-the-talk-implementing-a-communication-curriculum-for-surgical-residents
#15
Anna B Newcomb, Amber W Trickey, Melissa Porrey, Jeffrey Wright, Franco Piscitani, Paula Graling, Jonathan Dort
OBJECTIVES: The Accreditation Council for Graduate Medical Education milestones provide a framework of specific interpersonal and communication skills that surgical trainees should aim to master. However, training and assessment of resident nontechnical skills remains challenging. We aimed to develop and implement a curriculum incorporating interactive learning principles such as group discussion and simulation-based scenarios to formalize instruction in patient-centered communication skills, and to identify best practices when building such a program...
November 4, 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/27816023/kinematics-and-kinetics-during-stair-ascent-in-individuals-with-gluteal-tendinopathy
#16
Kim Allison, Bill Vicenzino, Kim L Bennell, Tim V Wrigley, Alison Grimaldi, Paul W Hodges
BACKGROUND: Individuals with gluteal tendinopathy commonly report lateral hip pain and disability during stair ascent. This study aimed to compare kinematics and kinetics between individuals with and without gluteal tendinopathy during a step up task. METHODS: 35 individuals with unilateral gluteal tendinopathy and 35 pain-free controls underwent three-dimensional motion analysis of stance phase during stair ascent. An analysis of covariance was performed to compare hip, pelvis and trunk kinematic and kinetic variables between groups...
October 5, 2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/27815821/expanding-a-common-metric-for-depression-reporting-linking-two-scales-to-promis-%C3%A2-depression
#17
Aaron J Kaat, Michael E Newcomb, Daniel T Ryan, Brian Mustanski
PURPOSE: Depression is a significant mental health concern. There are numerous depression questionnaires, several of which can be scored onto the Patient Reported Outcomes Measurement Information System (PROMIS(®)) Depression metric. This study expands the unified metric by linking depression subscales from the Adult Self-Report (ASR) and the Brief Symptom Inventory (BSI) to it. METHODS: An online sample of 2009 men who have sex with men (MSM) was recruited. Item factor analysis was used to evaluate the dimensionality of the aggregated measures and confirm the statistical assumptions for linking...
November 4, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27811119/alcohol-consumption-and-the-risk-of-colorectal-cancer-in-mismatch-repair-gene-mutation-carriers
#18
S Ghazaleh Dashti, Daniel D Buchanan, Harindra Jayasekara, Driss Ait Ouakrim, Mark Clendenning, Christophe Rosty, Ingrid M Winship, Finlay A Macrae, Graham G Giles, Susan Parry, Graham Casey, Robert W Haile, Steven Gallinger, Loic Le Marchand, Stephen N Thibodeau, Noralane M Lindor, Polly A Newcomb, John D Potter, John A Baron, John L Hopper, Mark A Jenkins, Aung Ko Win
Background People with germline mutation in one of the DNA mismatch repair (MMR) genes have increased colorectal cancer risk. For these high-risk people, study findings of the relationship between alcohol consumption and colorectal cancer risk have been inconclusive. Methods 1,925 MMR gene mutations carriers recruited into the Colon Cancer Family Registry who had completed a questionnaire on lifestyle factors were included. Weighted Cox proportional hazard regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between alcohol consumption and colorectal cancer...
November 3, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27810448/timing-of-adverse-prostate-cancer-reclassification-on-first-surveillance-biopsy-results-from-the-canary-prostate-cancer-active-surveillance-study
#19
Liam C Macleod, William J Ellis, Lisa F Newcomb, Yingye Zheng, James D Brooks, Peter R Carroll, Martin E Gleave, Raymond S Lance, Peter S Nelson, Ian M Thompson, Andrew A Wagner, John T Wei, Daniel W Lin
PURPOSE: During active surveillance (AS) for localized prostate cancer (PCa), first surveillance biopsy timing varies. We analyzed the Canary Prostate Cancer Active Surveillance Study (PASS), to determine biopsy timing influence on rates of PCa adverse reclassification at first AS biopsy. MATERIALS/METHODS: Of 1,085 participants in PASS, 421 had <34% cores involved with cancer, Gleason sum ≤6, and thereafter underwent on-study AS biopsy. Reclassification was defined as increase in Gleason sum and/or ≥34% of cores with PCa...
October 31, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27799157/prevalence-and-penetrance-of-major-genes-and-polygenes-for-colorectal-cancer
#20
Aung Ko Win, Mark A Jenkins, James G Dowty, Antonis C Antoniou, Andrew Lee, Graham G Giles, Daniel D Buchanan, Mark Clendenning, Christophe Rosty, Dennis J Ahnen, Stephen N Thibodeau, Graham Casey, Steven Gallinger, Loic Le Marchand, Robert W Haile, John D Potter, Yingye Zheng, Noralane M Lindor, Polly A Newcomb, John L Hopper, Robert J MacInnis
BACKGROUND: While high-risk mutations in identified major susceptibility genes (DNA mismatch repair genes and MUTYH) account for some familial aggregation of colorectal cancer, their population prevalence and the causes of the remaining familial aggregation are not known. METHODS: We studied the families of 5,744 colorectal cancer cases (probands) recruited from population cancer registries in the USA, Canada and Australia and screened probands for mutations in mismatch repair genes and MUTYH...
October 31, 2016: Cancer Epidemiology, Biomarkers & Prevention
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