Read by QxMD icon Read


Tara M Newcomb, Kevin M Flanigan
The cloning of the DMD gene, and the identifications of mutations in it as the cause of Duchenne muscular dystrophy (DMD), makes a compelling story that is aptly told elsewhere.(1) The locus-the largest in the human genome-consists of 79 exons, distributed over 2.5 million nucleotides on the X chromosome, which are assembled into a complementary DNA (cDNA) of around 14 kb encoding the predominant muscle isoform of the dystrophin protein.(2) The size of the gene, and the number of exons, had historically made mutation analysis challenging...
October 2016: Neurology. Genetics
Jian Gong, Carolyn M Hutter, Polly A Newcomb, Cornelia M Ulrich, Stephanie A Bien, Peter T Campbell, John A Baron, Sonja I Berndt, Stephane Bezieau, Hermann Brenner, Graham Casey, Andrew T Chan, Jenny Chang-Claude, Mengmeng Du, David Duggan, Jane C Figueiredo, Steven Gallinger, Edward L Giovannucci, Robert W Haile, Tabitha A Harrison, Richard B Hayes, Michael Hoffmeister, John L Hopper, Thomas J Hudson, Jihyoun Jeon, Mark A Jenkins, Jonathan Kocarnik, Sébastien Küry, Loic Le Marchand, Yi Lin, Noralane M Lindor, Reiko Nishihara, Shuji Ogino, John D Potter, Anja Rudolph, Robert E Schoen, Petra Schrotz-King, Daniela Seminara, Martha L Slattery, Stephen N Thibodeau, Mark Thornquist, Reka Toth, Robert Wallace, Emily White, Shuo Jiao, Mathieu Lemire, Li Hsu, Ulrike Peters
Genome-wide association studies (GWAS) have identified many genetic susceptibility loci for colorectal cancer (CRC). However, variants in these loci explain only a small proportion of familial aggregation, and there are likely additional variants that are associated with CRC susceptibility. Genome-wide studies of gene-environment interactions may identify variants that are not detected in GWAS of marginal gene effects. To study this, we conducted a genome-wide analysis for interaction between genetic variants and alcohol consumption and cigarette smoking using data from the Colon Cancer Family Registry (CCFR) and the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO)...
October 2016: PLoS Genetics
Brian A Feinstein, Michael E Newcomb
Young men who have sex with men (YMSM) report higher rates of substance use than their heterosexual peers and minority stress has been posited as a risk factor for substance use. The associations between specific types of minority stress and substance use have been inconsistent throughout the literature and few studies have examined mechanisms underlying these associations. Drawing on minority stress theory and the motivational model of alcohol use, we propose that one mechanism underlying these associations may be people's motivations for using substances, including using substances to cope with negative emotions and to enhance pleasure...
September 2016: Psychology of Sexual Orientation and Gender Diversity
Chrysanthi Fergani, Leanne Mazzella, Lique M Coolen, Richard B McCosh, Steven L Hardy, Nora Newcomb, Pasha Grachev, Michael N Lehman, Robert L Goodman
There is now general agreement that neurokinin B (NKB) acts via NK3R to stimulate secretion of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) in several species, including rats, mice, sheep, and humans. However the roles of two other tachykinins, substance P (SP) and neurokinin A (NKA), which act primarily via NK1R and NK2R respectively, are less clear. In rodents, these signaling pathways can stimulate LH release and substitute for NKB signaling; in humans, SP is colocalized with kisspeptin and NKB in the mediobasal hypothalamus...
October 5, 2016: Endocrinology
Kevin Hayes
No abstract text is available yet for this article.
October 2016: Statistical Methods in Medical Research
Barbara Sorondo, Amy Allen, Janet Bayleran, Stacy Doore, Samreen Fathima, Iyad Sabbagh, Lori Newcomb
INTRODUCTION: This project implemented an integrated patient self-reported screening tool in a patient portal and assessed clinical workflow and user experience in primary care practices. METHODS: An electronic health risk assessment based on the CMS Annual Wellness Visit (AWV) was developed to integrate self-reported health information into the patient's electronic health record (EHR). Patients enrolled in care coordination tested the implementation. The evaluation plan included quantitative and qualitative measures of patient adoption, provider adoption, workflow impact, financial impact, and technology impact...
2016: EGEMS
Gail Voncina, Patricia Newcomb
PURPOSE: The purpose of this project was to assess the impact of an enhanced postanesthesia unit (PACU) family visitation program on surgical services staff. DESIGN: This project was a cross-sectional study using a mixed methods approach. METHODS: A survey, including scaled and qualitative items, was administered to surgical services personnel. FINDINGS: A significant positive change occurred in respondents' feelings of comfort when providing emotional support to family members, and 2013 respondents agreed more often than earlier respondents with the notion that family members should have the option to visit in the PACU...
October 2016: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
Noralane M Lindor, Melissa C Larson, Melissa S DeRycke, Shannon K McDonnell, Saurabh Baheti, Zachary C Fogarty, Aung Ko Win, John D Potter, Daniel D Buchanan, Mark Clendenning, Polly A Newcomb, Graham Casey, Steven Gallinger, Loïc Le Marchand, John L Hopper, Mark A Jenkins, Ellen L Goode, Stephen N Thibodeau
MicroRNAs (miRNAs) regulate up to one-third of all protein-coding genes including genes relevant to cancer. Variants within miRNAs have been reported to be associated with prognosis, survival, response to chemotherapy across cancer types, in vitro parameters of cell growth, and altered risks for development of cancer. Five miRNA variants have been reported to be associated with risk for development of colorectal cancer (CRC). In this study, we evaluated germline genetic variation in 1,123 miRNAs in 899 individuals with CRCs categorized by clinical subtypes and in 204 controls...
September 16, 2016: Genes, Chromosomes & Cancer
Jesse K McKenney, Wei Wei, Sarah Hawley, Heidi Auman, Lisa F Newcomb, Hilary D Boyer, Ladan Fazli, Jeff Simko, Antonio Hurtado-Coll, Dean A Troyer, Maria S Tretiakova, Funda Vakar-Lopez, Peter R Carroll, Matthew R Cooperberg, Martin E Gleave, Raymond S Lance, Dan W Lin, Peter S Nelson, Ian M Thompson, Lawrence D True, Ziding Feng, James D Brooks
Histologic grading remains the gold standard for prognosis in prostate cancer, and assessment of Gleason score plays a critical role in active surveillance management. We sought to optimize the prognostic stratification of grading and developed a method of recording and studying individual architectural patterns by light microscopic evaluation that is independent of standard Gleason grade. Some of the evaluated patterns are not assessed by current Gleason grading (eg, reactive stromal response). Individual histologic patterns were correlated with recurrence-free survival in a retrospective postradical prostatectomy cohort of 1275 patients represented by the highest-grade foci of carcinoma in tissue microarrays...
November 2016: American Journal of Surgical Pathology
Judy Li, Rhiannon Newcombe, Hayley Guiney, Darren Walton
INTRODUCTION: New Zealand has implemented a series of seven annual increases in tobacco tax since 2010. All tax increases, except for the first in the series, were pre-announced. It is unusual for governments to introduce small, persistent, and predictable increases in tobacco tax, and little is known about the impact of such a strategy. This paper evaluates the impact of the 5(th) and 6(th) annual increases. METHOD: Smokers' behaviours were self-reported during the three-month period before, and the three-month period after, the two annual increases...
September 13, 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Christopher P Michetti, Heather A Prentice, Elena Lita, Jeffrey Wright, Edmond Ng, Anna B Newcomb
BACKGROUND: We sought to examine the effect on blood usage of a new electronic order set restricting transfusion orders to specific evidence-based criteria for each unit (U) of red blood cells (RBC), plasma, and platelets. METHODS: Prospectively collected transfusion data for Trauma ICU patients were compared for the 12 months before (PRE) and 8 months after (POST) order set implementation. Criteria for RBC transfusion were 1 U only for hemoglobin <7 g/dL in stable patients or <8 g/dL with angina, myocardial infarction, or cardiogenic shock; 2 U for hemoglobin <5 g/dL; and multiple U in the presence of shock, hypotension, or bleeding...
November 2016: Journal of Trauma and Acute Care Surgery
Phillip Smethurst, Jia Newcombe, Claire Troakes, Roberto Simone, Yun-Ru Chen, Rickie Patani, Katie Sidle
Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease (MND), and >95% of familial and sporadic cases involve the deposition of insoluble aggregated, phosphorylated and cleaved TDP-43 protein. Accumulating clinical and biological evidence now indicates that ALS bears a number of similarities to the prion diseases, with TDP-43 acting as a misfolded 'prion-like' protein demonstrating similar underlying pathobiology. Here we systematically address the hypothesis that ALS is a prion-like disorder...
August 30, 2016: Neurobiology of Disease
Abd Moain Abu Dabrh, Mohammad Hassan Murad, Richard D Newcomb, William G Buchta, Mark W Steffen, Zhen Wang, Amanda K Lovett, Lawrence W Steinkraus
BACKGROUND: Communication skills and professionalism are two competencies in graduate medical education that are challenging to evaluate. We aimed to develop, test and validate a de novo instrument to evaluate these two competencies. METHODS: Using an Objective Standardized Clinical Examination (OSCE) based on a medication error scenario, we developed an assessment instrument that focuses on distinctive domains [context of discussion, communication and detection of error, management of error, empathy, use of electronic medical record (EMR) and electronic medical information resources (EMIR), and global rating]...
2016: BMC Medical Education
Michael E Newcomb, Gregory Swann, Ryne Estabrook, Marya Corden, Mark Begale, Alan Ashbeck, David Mohr, Brian Mustanski
Behavioral diaries are used for observing health-related behaviors prospectively. Little is known about patterns and predictors of diary compliance to better understand differential attrition. An analytic sample of 241 young men who have sex with men (YMSM) from a 2-month diary study of substance use and sexual behavior were randomized to complete daily or weekly timeline followback diaries. Latent class growth analyses were used to analyze data. Weekly and daily diary groups produced similar compliance patterns: high, low, and declining compliance groups...
September 1, 2016: Assessment
Peter Grunert, Phillip M Reyes, Anna G U S Newcomb, Sara B Towne, Brian P Kelly, Nicholas Theodore, Roger Härtl
BACKGROUND: Multilevel lumbar stenosis, in which 1 level requires stabilization due to spondylolisthesis, is routinely treated with multilevel open laminectomy and fusion. We hypothesized that a minimally invasive (MI) decompression is biomechanically superior to open laminectomy and may allow decompression of the level adjacent the spondylolisthesis without additional fusion. OBJECTIVE: To study the mechanical effect of various decompression procedures adjacent to instrumented segments in cadaver lumbar spines...
August 30, 2016: Neurosurgery
Christopher P Michetti, Heather A Prentice, Jennifer Rodriguez, Anna Newcomb
BACKGROUND: We studied trauma-specific conditions precluding semiupright positioning and other nonmodifiable risk factors for their influence on ventilator-associated pneumonia (VAP). METHODS: We performed a retrospective study at a Level I trauma center from 2008 to 2012 on ICU patients aged ≥15, who were intubated for more than 2 days. Using backward logistic regression, a composite of 4 factors (open abdomen, acute spinal cord injury, spine fracture, spine surgery) that preclude semiupright positioning (supine composite) and other variables were analyzed...
July 28, 2016: American Journal of Surgery
Margaret Zronek, Holly Sanker, Jennifer Newcomb, Megan Donaldson
STUDY DESIGN: Systematic review of randomized controlled trials (RCT). OBJECTIVES: To examine the effects of a therapeutic home exercise program (HEP) for patients with neck pain (associated with whiplash, non-specific, or specific neck pain, with or without radiculopathy, or cervicogenic headache) on pain, function, and disability. Our secondary aim was to describe the design, dosage, and adherence of the prescribed HEPs. BACKGROUND: Neck pain is a leading cause of disability that affects 22-70% of the population...
May 2016: Journal of Manual & Manipulative Therapy
Eric G Bend, Yue Si, David A Stevenson, Pinar Bayrak-Toydemir, Tara M Newcomb, Erik M Jorgensen, Kathryn J Swoboda
OBJECTIVE: To perform genotype-phenotype analysis in an infant with congenital arthrogryposis due to a de novo missense mutation in the NALCN ion channel and explore the mechanism of pathogenicity using a Caenorhabditis elegans model. METHODS: We performed whole-exome sequencing in a preterm neonate with congenital arthrogryposis and a severe life-threatening clinical course. We examined the mechanism of pathogenicity of the associated NALCN mutation by engineering the orthologous mutation into the nematode C elegans using CRISPR-Cas9...
September 13, 2016: Neurology
Paul D Siakaluk, P Ian Newcombe, Brian Duffels, Eliza Li, David M Sidhu, Melvin J Yap, Penny M Pexman
Previous research has examined the effects of emotional experience (i.e., the ease with which words evoke emotion information) in semantic categorization (SCT), word naming, and Stroop tasks (Newcombe et al., 2012; Siakaluk et al., 2014; Moffat et al., 2015). However, to date there are no published reports on whether emotional experience influences performance in the lexical decision task (LDT). In the present study, we examined the influence of emotional experience in LDT using three different stimulus sets...
2016: Frontiers in Psychology
E M Babiker, T C Gordon, S Chao, M N Rouse, R Wanyera, M Newcomb, G Brown-Guedira, Z A Pretorius, J M Bonman
A gene for Ug99 resistance from wheat landrace CItr 4311 was detected on the long arm of chromosome 2B. Wheat landrace CItr 4311 has seedling resistance to stem rust caused by Puccinia graminis f. sp. tritici race TTKSK and field resistance to the Ug99 race group. Parents, F1 seedlings, 121 doubled haploid (DH) lines, and 124 recombinant inbred lines (RILs) developed from a cross between CItr 4311 and the susceptible line LMPG-6 were evaluated for seedling resistance to race TTKSK. Goodness-of-fit tests indicated that a single dominant gene in CItr 4311 conditioned the TTKSK resistance...
August 20, 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"