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https://www.readbyqxmd.com/read/29683699/minority-stress-and-relationship-functioning-among-young-male-same-sex-couples-an-examination-of-actor-partner-interdependence-models
#1
Brian A Feinstein, Elizabeth McConnell, Christina Dyar, Brian Mustanski, Michael E Newcomb
OBJECTIVE: In different-sex couples, individual and partner stress can both have a negative impact on relationship functioning (actor and partner effects). Gay and bisexual men experience unique stress (sexual minority stress), but few studies have examined the effects of this stress on relationship functioning among young male couples. The current study examined (a) actor and partner effects of general and minority stress (internalized stigma, microaggressions, victimization, and outness) on relationship functioning (relationship quality and negative relationship interactions), (b) interactions between individual and partner stress as predictors of relationship functioning, and (c) dyadic coping and relationship length as moderators of actor and partner effects...
May 2018: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/29678751/glucagon-like-peptide-1-receptor-signaling-attenuates-rsv-induced-type-2-responses-and-immunopathology
#2
Melissa H Bloodworth, Mark Rusznak, Connor C Pfister, Jian Zhang, Lisa Bastarache, Sandra Alvarez Calvillo, James D Chappell, Kelli L Boyd, Shinji Toki, Dawn C Newcomb, Matthew T Stier, Weisong Zhou, Kasia Goleniewska, Martin L Moore, Tina V Hartert, Kevin D Niswender, R Stokes Peebles
GLP-1R signaling, an emerging anti-inflammatory therapeutic target, attenuated type 2-associated immunopathology in mice infected with a strain of RSV that was isolated from a hospitalized infant with severe lower respiratory tract infection and bronchiolitis.
April 17, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29678304/improving-postoperative-neonatal-nutritional-practices-in-an-intensive-care-unit-using-the-pdsa-cycle
#3
Jennifer Newcombe, Eileen Fry-Bowers
Quality Improvement models offer a framework for health care professionals to follow in implementing process improvement changes. Use of these models promotes a systematic approach to problem solving, keeps providers from eliminating important steps, facilitates team work, and provides a clear plan for ongoing communication. This paper describes use of the Plan-Do-Study-Act model to implement a unit-based quality improvement project that focused on improving postoperative nutritional practices for neonates with critical congenital heart disease following complex cardiac surgery...
April 17, 2018: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/29660395/endogenous-pgi-2-signaling-through-ip-inhibits-neutrophilic-lung-inflammation-in-lps-induced-acute-lung-injury-mice-model
#4
Shinji Toki, Weisong Zhou, Kasia Goleniewska, Sara Reiss, Daniel E Dulek, Dawn C Newcomb, William E Lawson, R Stokes Peebles
Endogenous prostaglandin I2 (PGI2 ) has inhibitory effects on immune responses against pathogens or allergens; however, the immunomodulatory activity of endogenous PGI2 signaling in endotoxin-induced inflammation is unknown. To test the hypothesis that endogenous PGI2 down-regulates endotoxin-induced lung inflammation, C57BL/6 wild type (WT) and PGI2 receptor (IP) KO mice were challenged intranasally with LPS. Urine 6-keto-PGF1α , a stable metabolite of PGI2, was significantly increased following the LPS-challenge, suggesting that endogenous PGI2 signaling modulates the host response to LPS-challenge...
April 13, 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29628435/dependence-on-the-pyrimidine-biosynthetic-enzyme-dhodh-is-a-synthetic-lethal-vulnerability-in-mutant-kras-driven-cancers
#5
Malvika Koundinya, Judith Sudhalter, Albane Courjaud, Bruno Lionne, Gaetan Touyer, Luc Bonnet, Isabelle Menguy, Isabelle Schreiber, Christelle Perrault, Stephanie Vougier, Brigitte Benhamou, Bailin Zhang, Timothy He, Qiang Gao, Patricia Gee, Daniel Simard, M Paola Castaldi, Ronald Tomlinson, Stephan Reiling, Matthieu Barrague, Richard Newcombe, Hui Cao, Yanjun Wang, Fangxian Sun, Joshua Murtie, Mark Munson, Eric Yang, David Harper, Monsif Bouaboula, Jack Pollard, Claudine Grepin, Carlos Garcia-Echeverria, Hong Cheng, Francisco Adrian, Christopher Winter, Stuart Licht, Ivan Cornella-Taracido, Rosalia Arrebola, Aaron Morris
Activating KRAS mutations are major oncogenic drivers in multiple tumor types. Synthetic lethal screens have previously been used to identify targets critical for the survival of KRAS mutant cells, but their application to drug discovery has proven challenging, possibly due in part to a failure of monolayer cultures to model tumor biology. Here, we report the results of a high-throughput synthetic lethal screen for small molecules that selectively inhibit the growth of KRAS mutant cell lines in soft agar. Chemoproteomic profiling identifies the target of the most KRAS-selective chemical series as dihydroorotate dehydrogenase (DHODH)...
April 3, 2018: Cell Chemical Biology
https://www.readbyqxmd.com/read/29627459/tadpole-like-conformations-of-huntingtin-exon-1-are-characterized-by-conformational-heterogeneity-that-persists-regardless-of-polyglutamine-length
#6
Estella A Newcombe, Kiersten M Ruff, Ashish Sethi, Angelique R Ormsby, Yasmin M Ramdzan, Archa Fox, Anthony W Purcell, Paul R Gooley, Rohit V Pappu, Danny M Hatters
Soluble huntingtin exon 1 (Httex1) with expanded polyglutamine (polyQ) engenders neurotoxicity in Huntington's disease. To uncover the physical basis of this toxicity, we performed structural studies of soluble Httex1 for wild type and mutant polyQ lengths. Nuclear magnetic resonance experiments show evidence for conformational rigidity across the polyQ region. In contrast, hydrogen-deuterium exchange shows absence of backbone amide protection, suggesting negligible persistence of hydrogen bonds. The seemingly conflicting results are explained by all-atom simulations, which show that Httex1 adopts tadpole-like structures with a globular head encompassing the N-terminal amphipathic and polyQ regions and the tail encompassing the C-terminal proline-rich region...
April 5, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29620387/young-adult-gay-and-bisexual-men-s-stigma-experiences-and-mental-health-an-8-year-longitudinal-study
#7
John E Pachankis, Timothy J Sullivan, Brian A Feinstein, Michael E Newcomb
This study investigated longitudinal trajectories of stigma (i.e., enacted, anticipated, internalized, concealed); stress-sensitive mental health disorder symptoms (i.e., depression, social anxiety); and their associations across 8 annual assessments in a sample of 128 young gay and bisexual U.S. university students. All forms of stigma significantly decreased over time, while depressive symptoms remained stable and social anxiety symptoms significantly increased. Men from higher socioeconomic backgrounds experienced quicker reductions in anticipated stigma, compared to men from lower socioeconomic backgrounds...
April 5, 2018: Developmental Psychology
https://www.readbyqxmd.com/read/29608923/harnessing-the-potential-of-epigenetic-therapies-for-childhood-aml
#8
REVIEW
Ashley A Newcombe, Brenda E S Gibson, Karen Keeshan
There is a desperate need for new and effective therapeutic approaches for AML in both children and adults. Epigenetic aberrations are common in adult AML, and many novel epigenetic compounds are in clinical development that may improve patient outcomes. Mutations in epigenetic regulators occur less frequently in AML in children compared to adults. However, investigating the potential benefits of epigenetic therapy in paediatric AML is an important issue that will be discussed in this review.
March 30, 2018: Experimental Hematology
https://www.readbyqxmd.com/read/29597007/design-and-rationale-for-the-veterans-affairs-cooperative-study-program-594-comparative-effectiveness-in-gout-allopurinol-vs-febuxostat-trial
#9
S Timilsina, K Brittan, J R O'Dell, M Brophy, A Davis-Karim, A M Henrie, T Neogi, J Newcomb, P M Palevsky, M H Pillinger, D Pittman, T H Taylor, H Wu, T R Mikuls
BACKGROUND: Gout patients do not routinely achieve optimal outcomes related in part to suboptimal administration of urate lowering therapy (ULT) including first-line xanthine oxidase inhibitors allopurinol or febuxostat. Studies leading to the approval of febuxostat compared this agent to allopurinol in inappropriately low, fixed doses. We will compare allopurinol with febuxostat in gout using appropriately titrated doses of both agents and a "treat-to-target" strategy congruent with specialty guidelines...
March 26, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29582567/association-of-family-history-and-survival-in-patients-with-colorectal-cancer-a-pooled-analysis-of-eight-epidemiologic-studies
#10
Dawn Q Chong, Barbara L Banbury, Amanda I Phipps, Xinwei Hua, Jonathan Kocarnik, Ulrike Peters, Sonja I Berndt, Wen-Yi Huang, John D Potter, Martha L Slattery, Emily White, Peter T Campbell, Tabitha Harrison, Polly A Newcomb, Andrew T Chan
A family history of colorectal cancer (CRC) in first-degree relatives (FDRs) increases the risk of CRC. However, the influence of family history on survival among CRC patients remains unclear. We conducted a pooled analysis of survival in 5010 incident CRC cases. Cox proportional hazards models were used to estimate the association of family history with overall survival (OS) and CRC-specific survival (CSS). We also assessed the impact of the number of affected FDRs and age at CRC diagnosis in the affected FDRs on survival...
March 26, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29581038/levosimendan-following-cardiac-surgery
#11
Sean M Conte, Daniel S Florisson, Joshua A De Bono, Reece A Davies, Andrew E Newcomb
A best evidence topic was written to address if perioperative levosimendan improves mortality following cardiac surgery. Fourteen papers represented the best available evidence. An older meta-analysis summarising 11 of these trials concluded that there were fewer deaths in the levosimendan group compared to the control group (OR 0.41, p <0.001) however, this was driven by the results of three included trials by the same author. Three larger and more recent randomised controlled trials failed to demonstrate significant differences in mortality...
March 6, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29579209/does-minimally-invasive-coronary-artery-bypass-improve-outcomes-compared-to-off-pump-coronary-bypass-via-sternotomy-in-patients-undergoing-coronary-artery-bypass-grafting
#12
Daniel S Florisson, Joshua A DeBono, Reece A Davies, Andrew E Newcomb
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was 'In patients undergoing off-pump coronary artery bypass grafting, for single or multivessel disease, does minimally invasive direct coronary artery bypass (MIDCAB) or off-pump coronary artery bypass (OPCAB) provide the superior outcome including a reduction in morbidity and mortality?'. A total of 187 papers were found using the reported search, of which 12 represented the best evidence to answer the clinical question...
March 22, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29569000/the-influence-of-internalized-stigma-on-the-efficacy-of-an-hiv-prevention-and-relationship-education-program-for-young-male-couples
#13
Brian A Feinstein, Emily Bettin, Gregory Swann, Kathryn Macapagal, Sarah W Whitton, Michael E Newcomb
Young MSM are at increased risk for HIV, especially in the context of serious relationships, but there is a lack of couples-based HIV prevention for this population. The 2GETHER intervention-an HIV prevention and relationship education program for young male couples-demonstrated promising effects in a pilot trial. However, there is evidence that internalized stigma (IS) can influence treatment outcomes among MSM. The current study examined the influence of IS on the efficacy of the 2GETHER intervention among 57 young male couples...
March 22, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29563133/physical-activity-and-outcomes-in-patients-with-stage-iii-colon-cancer-a-correlative-analysis-of-phase-iii-trial-ncctg-n0147-alliance
#14
Amanda I Phipps, Qian Shi, Tyler J Zemla, Efrat Dotan, Sharlene Gill, Richard M Goldberg, Sheetal Hardikar, Balkrishna Jahagirdar, Paul J Limburg, Polly A Newcomb, Anthony Shields, Frank A Sinicrope, Daniel J Sargent, Steven R Alberts
BACKGROUND: Prior studies have supported an inverse association between physical activity and colon cancer risk, and suggest that higher physical activity may also improve cancer survival. Among participants in a phase III adjuvant trial for stage III colon cancer, we assessed the association of physical activity around the time of cancer diagnosis with subsequent outcomes. METHODS: Before treatment arm randomization (FOLFOX or FOLFOX+cetuximab), study participants completed a questionnaire including items regarding usual daily activity level and frequency of participation in recreational physical activity (N=1992)...
March 21, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29548956/biomechanical-analysis-of-an-expandable-lumbar-interbody-spacer
#15
Hector Soriano-Baron, Anna G U S Newcomb, Devika Malhotra, Atilio E Palma, Eduardo Martinez-Del-Campo, Neil R Crawford, Nicholas Theodore, Brian P Kelly, Taro Kaibara
OBJECTIVE: Recently developed expandable interbody spacers are widely accepted in spinal surgery; however, the resulting biomechanical effects of their use have not yet been fully studied. We analyzed the biomechanical effects of an expandable polyetheretherketone interbody spacer inserted through a bilateral posterior approach with and without different modalities of posterior augmentation. METHODS: Biomechanical nondestructive flexibility testing was performed in 7 human cadaveric lumbar (L2-L5) specimens followed by axial compressive loading...
March 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29540617/illusory-movement-perception-improves-motor-control-for-prosthetic-hands
#16
Paul D Marasco, Jacqueline S Hebert, Jon W Sensinger, Courtney E Shell, Jonathon S Schofield, Zachary C Thumser, Raviraj Nataraj, Dylan T Beckler, Michael R Dawson, Dan H Blustein, Satinder Gill, Brett D Mensh, Rafael Granja-Vazquez, Madeline D Newcomb, Jason P Carey, Beth M Orzell
To effortlessly complete an intentional movement, the brain needs feedback from the body regarding the movement's progress. This largely nonconscious kinesthetic sense helps the brain to learn relationships between motor commands and outcomes to correct movement errors. Prosthetic systems for restoring function have predominantly focused on controlling motorized joint movement. Without the kinesthetic sense, however, these devices do not become intuitively controllable. We report a method for endowing human amputees with a kinesthetic perception of dexterous robotic hands...
March 14, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29537902/urinary-magnesium-and-other-elements-in-relation-to-mammographic-breast-density-a-measure-of-breast-cancer-risk
#17
Maria C Mora-Pinzon, Amy Trentham-Dietz, Ronald E Gangnon, Scott V Adams, John M Hampton, Elizabeth Burnside, Martin M Shafer, Polly A Newcomb
PURPOSE: Heavy metals and other elements may act as breast carcinogens due to estrogenic activity. We investigated associations between urine concentrations of a panel of elements and breast density. METHODS: Mammographic density categories were abstracted from radiology reports of 725 women aged 40-65 yr in the Avon Army of Women. A panel of 27 elements was quantified in urine using high resolution magnetic sector inductively coupled plasma mass spectrometry. We applied LASSO (least absolute shrinkage and selection operator) logistic regression to the 27 elements and calculated odds ratios (OR) and 95% confidence intervals (CI) for dense vs...
March 14, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29537889/treatment-of-severe-problem-behaviour-in-children-with-autism-spectrum-disorder-and-intellectual-disabilities
#18
Eli T Newcomb, Louis P Hagopian
Children with autism spectrum disorder (ASD) and intellectual disabilities (ID) present with problem behaviour at rates disproportionately higher than their typically-developing peers. Problem behaviour, such as self-injury, aggression, pica, disruption, and elopement result in a diminished quality-of-life for the individual and family. Applied behaviour analysis has a well-established research base, detailing a number of assessment and treatment methods designed to address behaviour problems in children with ASD and ID...
March 14, 2018: International Review of Psychiatry
https://www.readbyqxmd.com/read/29535200/characterization-of-an-m-cluster-substituted-nitrogenase-vfe-protein
#19
Johannes G Rebelein, Chi Chung Lee, Megan Newcomb, Yilin Hu, Markus W Ribbe
The Mo- and V-nitrogenases are two homologous members of the nitrogenase family that are distinguished mainly by the presence of different heterometals (Mo or V) at their respective cofactor sites (M- or V-cluster). However, the V-nitrogenase is ~600-fold more active than its Mo counterpart in reducing CO to hydrocarbons at ambient conditions. Here, we expressed an M-cluster-containing, hybrid V-nitrogenase in Azotobacter vinelandii and compared it to its native, V-cluster-containing counterpart in order to assess the impact of protein scaffold and cofactor species on the differential reactivities of Mo- and V-nitrogenases toward CO...
March 13, 2018: MBio
https://www.readbyqxmd.com/read/29527241/barriers-to-gender-affirming-care-for-transgender-and-gender-nonconforming-individuals
#20
Jae A Puckett, Peter Cleary, Kinton Rossman, Michael E Newcomb, Brian Mustanski
Gender-affirming care, including hormone therapy, "top" (e.g., chest reconstruction surgery) and "bottom" (e.g., vaginoplasty, phalloplasty, metoidioplasty, etc.) surgeries, and puberty blockers, is an efficacious treatment of gender dysphoria for transgender and gender nonconforming (TGNC) individuals. However, many TGNC people encounter significant barriers in accessing gender-affirming care, which we detail via results from on online study. Participants included 256 TGNC individuals (78...
March 2018: Sexuality Research & Social Policy
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