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https://www.readbyqxmd.com/read/28779931/indonesian-provisional-clinical-psychologists-knowledge-attitudes-and-behaviours-towards-complementary-alternative-medicine-cam
#1
Andrian Liem, Peter A Newcombe
Sixty provisional clinical psychologists in Indonesia were emailed to seek their participation in an online-questionnaire that reflected: CAM knowledge, attitudes CAM, and CAM behaviours. Of the 60 participants approached, 44 with majority of female (95%) completed the questionnaire. The mean age of participants was 25 years. Overall, participants reported low knowledge of CAM and attitudes towards CAM were positive. While 73% reported having recommended CAM to their clients, only 39% had ever made referral...
August 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28756146/two-year-experience-implementing-a-curriculum-to-improve-residents-patient-centered-communication-skills
#2
Amber W Trickey, Anna B Newcomb, Melissa Porrey, Franco Piscitani, Jeffrey Wright, Paula Graling, Jonathan Dort
OBJECTIVES: Surgery milestones from The Accreditation Council for Graduate Medical Education have encouraged a focus on training and assessment of residents' nontechnical skills, including communication. We describe our 2-year experience implementing a simulation-based curriculum, results of annual communication performance assessments, and resident evaluations. DESIGN: Eight quarterly modules were conducted on various communication topics. Former patient volunteers served as simulation participants (SP) who completed annual assessments using the Communication Assessment Tool (CAT)...
July 26, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28746882/a-landscape-of-therapeutic-cooperativity-in-kras-mutant-cancers-reveals-principles-for-controlling-tumor-evolution
#3
Grace R Anderson, Peter S Winter, Kevin H Lin, Daniel P Nussbaum, Merve Cakir, Elizabeth M Stein, Ryan S Soderquist, Lorin Crawford, Jim C Leeds, Rachel Newcomb, Priya Stepp, Catherine Yip, Suzanne E Wardell, Jennifer P Tingley, Moiez Ali, Mengmeng Xu, Meagan Ryan, Shannon J McCall, Autumn J McRee, Christopher M Counter, Channing J Der, Kris C Wood
Combinatorial inhibition of effector and feedback pathways is a promising treatment strategy for KRAS mutant cancers. However, the particular pathways that should be targeted to optimize therapeutic responses are unclear. Using CRISPR/Cas9, we systematically mapped the pathways whose inhibition cooperates with drugs targeting the KRAS effectors MEK, ERK, and PI3K. By performing 70 screens in models of KRAS mutant colorectal, lung, ovarian, and pancreas cancers, we uncovered universal and tissue-specific sensitizing combinations involving inhibitors of cell cycle, metabolism, growth signaling, chromatin regulation, and transcription...
July 25, 2017: Cell Reports
https://www.readbyqxmd.com/read/28741737/effect-of-exogenous-progesterone-administration-on-luteal-sensitivity-to-pgf-during-the-early-development-of-the-corpus-luteum-in-mares-and-cows
#4
A Garcia-Muñoz, X Valldecabres-Torres, J R Newcombe, J Cuervo-Arango, E Garcia-Rosello
The objective of this study was to determine the effect of exogenous progesterone administration at ovulation and during the early development of the CL, on its future sensitivity to a single administration of PGF2a in mares and cows. Horse Retrospective reproductive data from an equine clinic in the UK during three breeding seasons were used. Mares were divided into: control group, cycles with single ovulations; double ovulation group cycles with asynchronous double ovulations; and PRID group: cycles with single ovulations and treatment with intravaginal progesterone device (CIDR) immediately after the ovulation...
July 25, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28735820/evaluation-of-complementary-alternative-medicine-cam-questionnaire-development-for-indonesian-clinical-psychologists-a-pilot-study
#5
Andrian Liem, Peter A Newcombe, Annie Pohlman
This study aimed to evaluate questionnaire development to measure the knowledge of Complementary-Alternative Medicine (CAM), attitudes towards CAM, CAM experiences, and CAM educational needs of clinical psychologists in Indonesia. A 26-item questionnaire was developed through an extensive literature search. Data was obtained from provisional psychologists from the Master of Professional Clinical Psychology programs at two established public universities in urban areas of Indonesia. To validate the questionnaire, panel reviews by executive members of the Indonesian Clinical Psychology Association (ICPA), experts in health psychology, and experts in public health and CAM provided their professional judgements...
August 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28734297/nonequilibrium-phase-coexistence-and-criticality-near-the-second-explosion-limit-of-hydrogen-combustion
#6
Lucas B Newcomb, Mohammad Alaghemandi, Jason R Green
While hydrogen is a promising source of clean energy, the safety and optimization of hydrogen technologies rely on controlling ignition through explosion limits: pressure-temperature boundaries separating explosive behavior from comparatively slow burning. Here, we show that the emergent nonequilibrium chemistry of combustible mixtures can exhibit the quantitative features of a phase transition. With stochastic simulations of the chemical kinetics for a model mechanism of hydrogen combustion, we show that the boundaries marking explosive domains of kinetic behavior are nonequilibrium critical points...
July 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28733826/validation-of-the-hiv-risk-assessment-of-sexual-partnerships-h-rasp-comparison-to-a-2-month-prospective-diary-study
#7
Gregory Swann, Michael E Newcomb, Brian Mustanski
The HIV Risk Assessment of Sexual Partnerships (H-RASP) was developed in order to create a retrospective measure of sexual risk-taking that can account for the differing contexts of sexual partnership(s) within a specified period of time. In order to validate the H-RASP relative to other methods of measuring sexual risk-taking, measurements from the H-RASP were compared to data from a prospective diary study of 95 young men who have sex with men over the same two-month period. We found that the H-RASP was not significantly different at measuring participants' total number of sexual partners and total number of anal sex partners in comparison with the diaries...
July 21, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28707953/neural-correlates-of-visual-memory-in-patients-with-diffuse-axonal-injury
#8
Juliane Lauer, Laura Moreno-López, Anne Manktelow, Ellen L Carroll, Joanne G Outtrim, Jonathan P Coles, Virginia F Newcombe, Barbara J Sahakian, David K Menon, Emmanuel A Stamatakis
PRIMARY OBJECTIVE: To investigate the neural substrates of visual memory in a sample of patients with traumatic brain injury (TBI). We hypothesized that patients with decreased grey and white matter volume in frontal and parietal cortices as well as medial temporal and occipital lobes would perform poorly on the tests of visual memory analysed. METHODS AND PROCEDURES: 39 patients and 53 controls were assessed on tests of visual memory and learning from the Cambridge Neuropsychological Test Automated Battery (CANTAB)...
July 14, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28692946/victimization-as-a-mediator-of-alcohol-use-disparities-between-sexual-minority-subgroups-and-sexual-majority-youth-using-the-2015-national-youth-risk-behavior-survey
#9
Gregory Phillips, Blair Turner, Paul Salamanca, Michelle Birkett, Mark L Hatzenbuehler, Michael E Newcomb, Rachel Marro, Brian Mustanski
BACKGROUND: Alcohol use among underage youth is a significant public health concern. According to the National Institute on Alcohol Abuse and Alcoholism, alcohol is the "drug of choice" among adolescents, meaning more youth use and abuse alcohol than any other substance. Prevalence of alcohol use is disproportionately higher among sexual minority youth (SMY) than among their heterosexual peers. We examined sexual identity and sexual behavior disparities in alcohol use, and the mediational role of bullying in a sample of high school students...
September 1, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28667941/trajectories-of-alcohol-marijuana-and-illicit-drug-use-in-a-diverse-sample-of-young-men-who-have-sex-with-men
#10
Gregory Swann, Emily Bettin, Antonia Clifford, Michael E Newcomb, Brian Mustanski
INTRODUCTION: Cross-sectional research has found that young men who have sex with men (YMSM) are more likely to engage in heavy drinking and to have higher rates of marijuana and other illicit drug use compared to their heterosexual peers, but considerably less is known about their patterns of substance use over time. METHODS: In this study, we combined two longitudinal samples of racially diverse YMSM (N=552) and modeled their substance use trajectories from late-adolescence to young adulthood, including their frequency of alcohol use, frequency of marijuana use, and poly-drug use, using piecewise latent curve growth modeling to model change from ages 17-21 and change from ages 22-24...
June 21, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28657988/vaginal-uterosacral-ligament-suspension-a-retrospective-cohort-of-absorbable-and-permanent-suture-groups
#11
Megan S Bradley, Jennifer A Bickhaus, Cindy L Amundsen, Laura K Newcomb, Tracy Truong, Alison C Weidner, Nazema Y Siddiqui
OBJECTIVE: The aim of this study was to compare anatomic results after vaginal uterosacral ligament suspension with absorbable versus permanent suture. METHODS: We performed a retrospective cohort study of women who underwent vaginal uterosacral ligament suspension, from 2006 to 2015. We compared 2 groups: (1) absorbable suspension suture and (2) permanent suspension suture (even if accompanied by absorbable suture). Our primary outcome was composite anatomic failure defined as (1) recurrent prolapse in any compartment past the hymen or (2) retreatment for prolapse...
June 27, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28653153/application-of-benford-s-law-a-valuable-tool-for-detecting-scientific-papers-with-fabricated-data-a%C3%A2-case-study-using-proven-falsified-articles-against-a%C3%A2-comparison-group
#12
REVIEW
S Hüllemann, G Schüpfer, J Mauch
BACKGROUND: In naturally occurring numbers the frequencies of digits 1-9 in the leading position are counterintuitively distributed because the frequencies of occurrence are unequal. Benford-Newcomb's law describes the expected distribution of these frequencies. It was previously shown that known fraudulent articles consistently violated this law. OBJECTIVE: To compare the features of 12 known fraudulent articles from a single Japanese author to the features of 13 articles in the same research field from other Japanese authors, published during the same time period and identified with a Medline database search...
June 26, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/28647467/reliability-and-measurement-error-of-the-osteoarthritis-research-society-international-oarsi-recommended-performance-based-tests-of-physical-function-in-people-with-hip-and-knee-osteoarthritis
#13
F Dobson, R S Hinman, M Hall, C J Marshall, T Sayer, C Anderson, N Newcomb, P W Stratford, K L Bennell
OBJECTIVE: To estimate the reliability and measurement error of performance-based tests of physical function recommended by the Osteoarthritis Research Society International (OARSI) in people with hip and/or knee osteoarthritis (OA). DESIGN: Prospective repeated measures between independent raters within a session and within-rater over a week interval. Relative reliability was estimated for 51 people with hip and/or knee OA (mean age 64.5 years, standard deviation (SD) 6...
June 22, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28636349/water-dynamics-from-the-surface-to-the-interior-of-a-supramolecular-nanostructure
#14
Julia H Ortony, Baofu Qiao, Christina J Newcomb, Timothy J Keller, Liam C Palmer, Elad Deiss-Yehiely, Monica Olvera de la Cruz, Songi Han, Samuel I Stupp
Water within and surrounding the structure of a biological system adopts context-specific dynamics that mediate virtually all of the events involved in the inner workings of a cell. These events range from protein folding and molecular recognition to the formation of hierarchical structures. Water dynamics are mediated by the chemistry and geometry of interfaces where water and biomolecules meet. Here we investigate experimentally and computationally the translational dynamics of vicinal water molecules within the volume of a supramolecular peptide nanofiber measuring 6...
June 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28635983/risk-factors-for-re-excision-following-breast-conserving-surgery
#15
Kimberly Rodriguez, Gayle G Wilkins, Patricia Newcomb, Patricia A Gwirtz, Robin Skrine
PURPOSE/OBJECTIVES: To identify previously unstudied factors predicting re-excision following breast-conserving surgery (BCS) and to assess the feasibility of obtaining data about breast density for predictive modeling.
. DESIGN: Retrospective secondary data analysis.
. SETTING: Data were obtained from the cancer registry and electronic health records (EHRs) at Texas Health Harris Methodist Hospital, a large, urban, private, nonprofit hospital in North Texas...
May 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28624761/factors-influencing-psychological-social-and-health-outcomes-after-major-burn-injuries-in-adults-cohort-study-protocol
#16
Martha Druery, Peter A Newcombe, Cate M Cameron, Jeffrey Lipman
INTRODUCTION: The goal of burn care is that 'the quality of the outcome must be worth the pain of survival'. More research is needed to understand how best to deliver care for patients with burns to achieve this aim. Loss of independence, function as well as loss of income for patients with burns and carers cause a significant burden at both individual and societal levels. Much is being done to advance knowledge in the clinical care field; however, there has been a paucity of research exploring psychosocial outcomes...
June 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28617623/timing-of-aspirin-and-other-nonsteroidal-anti-inflammatory-drug-use-among-patients-with-colorectal-cancer-in-relation-to-tumor-markers-and-survival
#17
Xinwei Hua, Amanda I Phipps, Andrea N Burnett-Hartman, Scott V Adams, Sheetal Hardikar, Stacey A Cohen, Jonathan M Kocarnik, Dennis J Ahnen, Noralane M Lindor, John A Baron, Polly A Newcomb
Purpose Regular use of aspirin is associated with improved survival for patients with colorectal cancer (CRC). However, the timing of and the subtype of CRC that would benefit the most from using aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) in relation to survival is unclear. Patients and Methods In all, 2,419 patients age 18 to 74 years with incident invasive CRC who were diagnosed from 1997 to 2008 were identified from population-based cancer registries in the United States, Canada, and Australia...
June 15, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28611252/the-primary-enveloped-virion-of-herpes-simplex-virus-1-its-role-in-nuclear-egress
#18
William W Newcomb, Juan Fontana, Dennis C Winkler, Naiqian Cheng, J Bernard Heymann, Alasdair C Steven
Many viruses migrate between different cellular compartments for successive stages of assembly. The HSV-1 capsid assembles in the nucleus and then transfers into the cytoplasm. First, the capsid buds through the inner nuclear membrane, becoming coated with nuclear egress complex (NEC) protein. This yields a primary enveloped virion (PEV) whose envelope fuses with the outer nuclear membrane, releasing the capsid into the cytoplasm. We investigated the associated molecular mechanisms by isolating PEVs from US3-null-infected cells and imaging them by cryo-electron microscopy and tomography...
June 13, 2017: MBio
https://www.readbyqxmd.com/read/28601531/sheep-as-a-large-animal-ear-model-middle-ear-ossicular-velocities-and-intracochlear-sound-pressure
#19
Dominik Péus, Ivo Dobrev, Lukas Prochazka, Konrad Thoele, Adrian Dalbert, Andreas Boss, Nicolas Newcomb, Rudolf Probst, Christof Röösli, Jae Hoon Sim, Alexander Huber, Flurin Pfiffner
Animals are frequently used for the development and testing of new hearing devices. Dimensions of the middle ear and cochlea differ significantly between humans and commonly used animals, such as rodents or cats. The sheep cochlea is anatomically more like the human cochlea in size and number of turns. This study investigated the middle-ear ossicular velocities and intracochlear sound pressure (ICSP) in sheep temporal bones, with the aim of characterizing the sheep as an experimental model for implantable hearing devices...
August 2017: Hearing Research
https://www.readbyqxmd.com/read/28594759/associations-of-parity-breastfeeding-and-fractures-in-the-women-s-health-observational-study
#20
Carolyn J Crandall, Jingmin Liu, Jane Cauley, Polly A Newcomb, JoAnn E Manson, Mara Z Vitolins, Lisette T Jacobson, Kelli K Rykman, Marcia L Stefanick
OBJECTIVE: To examine associations of several aspects of parity and history of lactation with incident hip fractures and clinical fractures and, in a subset of women, with bone mineral density. METHODS: In this observational study, we analyzed data from 93,676 postmenopausal women participating in the Women's Health Initiative Observational Study and all bone density data from the subset of participants who underwent bone density testing at three clinical centers...
July 2017: Obstetrics and Gynecology
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