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https://www.readbyqxmd.com/read/28227973/improving-odorant-chemical-class-prediction-with-multi-layer-perceptrons-using-temporal-odorant-spike-responses-from-drosophila-melanogaster-olfactory-receptor-neurons
#1
Luqman R Bachtiar, Richard D Newcomb, Andrew V Kralicek, Charles P Unsworth, Luqman R Bachtiar, Richard D Newcomb, Andrew V Kralicek, Charles P Unsworth, Charles P Unsworth, Andrew V Kralicek, Richard D Newcomb, Luqman R Bachtiar
In this work, we examine the possibility of improving the prediction performance of an olfactory biosensor through the use of temporal spiking data. We present an Artificial Neural Network (ANN), in the form of an optimal hybrid Multi-Layer Perceptron (MLP) system for the classification of chemical odorants from olfactory receptor neuron spike responses of the Drosophila melanogaster fruit fly (DmOrs). The data used in this study contains the responses to 34 odorants from 6 individual DmOrs, of which we exploit the temporal spiking responses of a 500ms odorant stimulus window...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28219897/vera-alma-sullivan
#2
Rosalind Hirst, Joyce Newcombe
No abstract text is available yet for this article.
February 20, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28205046/reproductive-factors-and-risk-of-colorectal-polyps-in-a-colonoscopy-based-study-in-western-washington-state
#3
Sheetal Hardikar, Andrea N Burnett-Hartman, Jessica Chubak, Melissa P Upton, Lee-Ching Zhu, John D Potter, Polly A Newcomb
BACKGROUND: Oral contraceptives (OC) are associated with a decreased risk of colorectal cancers; however, a recent study reported an increased risk of small colorectal adenomas associated with OC use. To determine if these results were replicable in a different study population, we investigated the relationship between OC use and other reproductive factors and risk of colorectal polyps in a case-control study in western Washington. METHODS: Study participants were 24-79-year-old female enrollees at an integrated health care system in western Washington who were diagnosed as having adenomas (n = 299), serrated polyps (n = 337), both types of polyps (n = 105) or as polyp-free controls (n = 615) through an index colonoscopy and completed a structured interview to collect reproductive history information...
February 15, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28194606/sexual-partner-typologies-and-the-association-between-drug-use-and-sexual-risk-behavior-among-young-men-who-have-sex-with-men
#4
Patrick Janulis, Brian A Feinstein, Gregory Phillips, Michael E Newcomb, Michelle Birkett, Brian Mustanski
Numerous partner and relationship characteristics are associated with sexual risk behavior among young men who have sex with men (YMSM), including being in a serious relationship and having older partners. However, most research in this area is limited by its reliance on variable-centered approaches. Using multilevel latent class analysis, this study identified subgroups of sexual partner types with a particular emphasis on examining whether partner type moderated the association between drug use and condomless anal sex (CAS)...
February 13, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28184430/prediction-of-overall-survival-in-stage-ii-and-iii-colon-cancer-beyond-tnm-system-a-retrospective-pooled-biomarker-study
#5
R Dienstmann, M J Mason, F A Sinicrope, A I Phipps, S Tejpar, A Nesbakken, S A Danielsen, A Sveen, D D Buchanan, M Clendenning, C Rosty, B Bot, S R Alberts, J Milburn Jessup, R A Lothe, M Delorenzi, P A Newcomb, D Sargent, J Guinney
No abstract text is available yet for this article.
February 9, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28181251/iv-results-links-between-spatial-assembly-later-spatial-skills-and-concurrent-and-later-mathematical-skills
#6
Brian N Verdine, Roberta Michnick Golinkoff, Kathy Hirsh-Pasek, Nora S Newcombe
No abstract text is available yet for this article.
March 2017: Monographs of the Society for Research in Child Development
https://www.readbyqxmd.com/read/28181249/v-results-individual-difference-factors-in-spatial-and-mathematical-skills
#7
Brian N Verdine, Roberta Michnick Golinkoff, Kathy Hirsh-Pasek, Nora S Newcombe
No abstract text is available yet for this article.
March 2017: Monographs of the Society for Research in Child Development
https://www.readbyqxmd.com/read/28181248/i-spatial-skills-their-development-and-their-links-to-mathematics
#8
Brian N Verdine, Roberta Michnick Golinkoff, Kathy Hirsh-Pasek, Nora S Newcombe
Understanding the development of spatial skills is important for promoting school readiness and improving overall success in STEM (science, technology, engineering, and mathematics) fields (e.g., Wai, Lubinski, Benbow, & Steiger, 2010). Children use their spatial skills to understand the world, including visualizing how objects fit together, and can practice them via spatial assembly activities (e.g., puzzles or blocks). These skills are incorporated into measures of overall intelligence and have been linked to success in subjects like mathematics (Mix & Cheng, 2012) and science (Pallrand & Seeber, 1984; Pribyl & Bodner, 1987)...
March 2017: Monographs of the Society for Research in Child Development
https://www.readbyqxmd.com/read/28181247/vi-discussion-and-implications-how-early-spatial-skills-predict-later-spatial-and-mathematical-skills
#9
Brian N Verdine, Roberta Michnick Golinkoff, Kathy Hirsh-Pasek, Nora S Newcombe
No abstract text is available yet for this article.
March 2017: Monographs of the Society for Research in Child Development
https://www.readbyqxmd.com/read/28181246/ii-methods-for-longitudinal-study-of-preschool-spatial-and-mathematical-skills
#10
Brian N Verdine, Roberta Michnick Golinkoff, Kathy Hirsh-Pasek, Nora S Newcombe
No abstract text is available yet for this article.
March 2017: Monographs of the Society for Research in Child Development
https://www.readbyqxmd.com/read/28181245/iii-results-considering-the-2-d-and-3-d-trials-of-the-tosa-separately-and-together
#11
Brian N Verdine, Roberta Michnick Golinkoff, Kathy Hirsh-Pasek, Nora S Newcombe
No abstract text is available yet for this article.
March 2017: Monographs of the Society for Research in Child Development
https://www.readbyqxmd.com/read/28173821/identification-of-influenza-a-nucleoprotein-body-domain-residues-essential-for-viral-rna-expression-expose-antiviral-target
#12
Alicia M Davis, Jose Ramirez, Laura L Newcomb
BACKGROUND: Influenza A virus is controlled with yearly vaccination while emerging global pandemics are kept at bay with antiviral medications. Unfortunately, influenza A viruses have emerged resistance to approved influenza antivirals. Accordingly, there is an urgent need for novel antivirals to combat emerging influenza A viruses resistant to current treatments. Conserved viral proteins are ideal targets because conserved protein domains are present in most, if not all, influenza subtypes, and are presumed less prone to evolve viable resistant versions...
February 7, 2017: Virology Journal
https://www.readbyqxmd.com/read/28169533/ignition-in-an-atomistic-model-of-hydrogen-oxidation
#13
Mohammad Alaghemandi, Lucas B Newcomb, Jason R Green
Hydrogen is a potential substitute for fossil fuels that would reduce the combustive emission of carbon dioxide. However, the low ignition energy needed to initiate oxidation imposes constraints on the efficiency and safety of hydrogen-based technologies. Microscopic details of the combustion processes, ephemeral transient species, and complex reaction networks are necessary to control and optimize the use of hydrogen as a commercial fuel. Here, we report estimates of the ignition time of hydrogen-oxygen mixtures over a wide range of equivalence ratios from extensive reactive molecular dynamics simulations...
February 16, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28166454/potential-reservoirs-and-risk-factors-for-vhsv-ivb-in-an-enzootic-system-budd-lake-michigan
#14
Elizabeth Throckmorton, Travis Brenden, Amber K Peters, Tammy J Newcomb, Gary E Whelan, Mohamed Faisal
Viral hemorrhagic septicemia virus genotype IVb (VHSV IVb) has caused major, sporadic fish die-offs in the Laurentian Great Lakes region of North America since 2005. Presently, factors affecting VHSV IVb persistence in enzootic systems are not well understood. Even with annual surveillance, the virus can go undetected for several years after an outbreak before again re-emerging, which suggests that the virus is maintained in the system either below detectable levels or in untested reservoirs. The aim of this study was to identify potential reservoirs of VHSV IVb in Budd Lake, Michigan; VHSV IVb was first detected in Budd Lake in 2007 but remained undetected until 2011...
March 2017: Journal of Aquatic Animal Health
https://www.readbyqxmd.com/read/28161365/a-randomised-clinical-trial-to-determine-the-abrasive-effect-of-the-tongue-on-human-enamel-loss-with-and-without-a-prior-erosive-challenge
#15
J Seong, N Claydon, E Macdonald, S Garner, R G Newcombe, N West
OBJECTIVES: To investigate the abrasive effect of the tongue on human enamel loss with and without a prior dietary acid challenge in an in situ model. METHODS: A single centre, single blind, randomly allocated, split mouth, four treatment regimen, in situ study in healthy adult volunteers was undertaken. Twenty four subjects wore two lower intra-oral appliances each fitted with 4 human enamel samples 6h/day for 15 days. The samples were treated with either 50ml orange juice or water for 5min ex vivo 4x/day; prior to being licked or not licked with the subject's tongue for 60s...
February 1, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28150959/multiple-views-of-space-continuous-visual-flow-enhances-small-scale-spatial-learning
#16
Corinne A Holmes, Steven A Marchette, Nora S Newcombe
In the real word, we perceive our environment as a series of static and dynamic views, with viewpoint transitions providing a natural link from one static view to the next. The current research examined if experiencing such transitions is fundamental to learning the spatial layout of small-scale displays. In Experiment 1, participants viewed a tabletop array from 4 orientations in 1 of 3 conditions. The control condition presented the array sequentially, as a series of static views. In the remaining conditions, participants experienced the transition between viewpoints by rotating the array or moving around it...
February 2, 2017: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/28138349/the-impact-of-victimization-and-neuroticism-on-mental-health-in-young-men-who-have-sex-with-men-internalized-homophobia-as-an-underlying-mechanism
#17
Jae A Puckett, Michael E Newcomb, Robert Garofalo, Brian Mustanski
Sexual minorities experience greater mental health issues compared to heterosexuals due to minority stressors. This study focused on the impact of victimization and neuroticism on mental health in young men who have sex with men (YMSM), and the mediating role of internalized homophobia (IH). IH refers to when a sexual minority person internalizes social bias and develops a negative view of themselves, which is a likely process through which victimization and neuroticism impact mental health. Data were collected over three time points across 12 months, with 450 YMSM (mean age = 18...
September 2016: Sexuality Research & Social Policy: Journal of NSRC: SR & SP
https://www.readbyqxmd.com/read/28124182/examining-the-conditions-under-which-internalized-homophobia-is-associated-with-substance-use-and-condomless-sex-in-young-msm-the-moderating-role-of-impulsivity
#18
Jae A Puckett, Michael E Newcomb, Robert Garofalo, Brian Mustanski
BACKGROUND: Internalized homophobia (IH) is the internalization of homophobic attitudes by sexual minorities due to social bias. IH has been inconsistently related to substance use and condomless sex for young men who have sex with men (YMSM). PURPOSE: We examined negative urgency (the tendency to act impulsively in response to negative emotional experiences), positive urgency (the tendency to act impulsively in response to positive emotional experiences), and sensation seeking as independent moderators of the association of IH with binge drinking, drug use, and condomless anal sex...
January 25, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/28094373/conformational-dynamics-and-self-association-of-intrinsically-disordered-huntingtin-exon-1-in-cells
#19
Steffen Büning, Abhishek Sharma, Shivang Vachharajani, Estella Newcombe, Angelique Ormsby, Mimi Gao, David Gnutt, Tobias Vöpel, Danny M Hatters, Simon Ebbinghaus
Huntington's disease is caused by a CAG trinucleotide expansion mutation in the Huntingtin gene that leads to an artificially long polyglutamine sequence in the Huntingtin protein. A key feature of the disease is the intracellular aggregation of the Huntingtin exon 1 protein (Httex1) into micrometer sized inclusion bodies. The aggregation process of Httex1 has been extensively studied in vitro, however, the crucial early events of nucleation and aggregation in the cell remain elusive. Here, we studied the conformational dynamics and self-association of Httex1 by in-cell experiments using laser-induced temperature jumps and analytical ultracentrifugation...
January 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28063770/a-post-operative-feeding-protocol-to-improve-outcomes-for-neonates-with-critical-congenital-heart-disease
#20
Jennifer Newcombe, Eileen Fry-Bowers
Neonates with critical congenital heart disease (CCHD) are vulnerable to malnutrition during the post-operative period due to hypermetabolism and hypercatabolism. To improve nutritional outcomes during hospitalization, a nurse led post-operative enteral feeding protocol was implemented at a large U.S. children's hospital. During an eight-month implementation period, twenty-one neonates met protocol inclusion criteria. Days for neonates to achieve goal caloric feedings (120kcal/kg/day) were decreased. A one-way repeated measures analysis of variance showed serum albumin levels and serial anthropometric measurements improved significantly throughout hospitalization (p<0...
January 4, 2017: Journal of Pediatric Nursing
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