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https://www.readbyqxmd.com/read/28340513/mendelian-randomisation-implicates-hyperlipidaemia-as-a-risk-factor-for-colorectal-cancer
#1
Henry Rodriguez-Broadbent, Philip J Law, Amit Sud, Kimmo Palin, Sari Tuupanen, Alexandra Gylfe, Ulrika A Hänninen, Tatiana Cajuso, Tomas Tanskanen, Johanna Kondelin, Eevi Kaasinen, Antti-Pekka Sarin, Samuli Ripatti, Johan G Eriksson, Harri Rissanen, Paul Knekt, Eero Pukkala, Pekka Jousilahti, Veikko Salomaa, Aarno Palotie, Laura Renkonen-Sinisalo, Anna Lepistö, Jan Böhm, Jukka-Pekka Mecklin, Nada A Al-Tassan, Claire Palles, Lynn Martin, Ella Barclay, Susan M Farrington, Maria N Timofeeva, Brian F Meyer, Salma M Wakil, Harry Campbell, Christopher G Smith, Shelley Idziaszczyk, Timothy S Maughan, Richard Kaplan, Rachel Kerr, David Kerr, Michael N Passarelli, Jane C Figueiredo, Daniel D Buchanan, Aung K Win, John L Hopper, Mark A Jenkins, Noralane M Lindor, Polly A Newcomb, Steven Gallinger, David Conti, Fred Schumacher, Graham Casey, Lauri A Aaltonen, Jeremy P Cheadle, Ian P Tomlinson, Malcolm G Dunlop, Richard S Houlston
While elevated blood cholesterol has been associated with an increased risk of colorectal cancer (CRC) in observational studies, causality is uncertain. Here we apply a Mendelian randomisation (MR) analysis to examine the potential causal relationship between lipid traits and CRC risk. We used single nucleotide polymorphisms (SNPs) associated with blood levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) as instrumental variables (IV). We calculated MR estimates for each risk factor with CRC using SNP-CRC associations from 9,254 cases and 18,386 controls...
March 24, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28332107/mechanisms-driving-gender-differences-in-asthma
#2
REVIEW
Hubaida Fuseini, Dawn C Newcomb
PURPOSE OF REVIEW: Many phenotypes of asthma exist, ranging from mild asthma with onset during childhood to severe asthma with later onset, making asthma a broad disease with different pathologies. A gender disparity exists in asthma prevalence. As adults, women have an increased asthma prevalence compared to men. Further, women are more likely to have severe asthma and a later onset of asthma compared to men. Here, we review clinical and animal studies that have defined the role of sex hormones in airway inflammation, smooth muscle contraction, mucus production, and airway mechanics associated with asthma pathogenesis...
March 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28325125/pregnancy-complicated-by-foetal-abdominal-mass-fetiform-teratoma-versus-foetus-in-fetu
#3
Laura K Newcomb, Eleanor H J Rhee, Sarah M Bean, Jina Kim, Elisabeth T Tracy, Jeffrey A Kuller
No abstract text is available yet for this article.
March 21, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28322247/tricyclic-antidepressants-promote-ceramide-accumulation-to-regulate-collagen-production-in-human-hepatic-stellate-cells
#4
Jennifer Y Chen, Benjamin Newcomb, Chan Zhou, Joshua V Pondick, Sarani Ghoshal, Samuel R York, Daniel L Motola, Nicolas Coant, Jae Kyo Yi, Cungui Mao, Kenneth K Tanabe, Irina Bronova, Evgeny V Berdyshev, Bryan C Fuchs, Yusuf Hannun, Raymond T Chung, Alan C Mullen
Activation of hepatic stellate cells (HSCs) in response to injury is a key step in hepatic fibrosis, and is characterized by trans-differentiation of quiescent HSCs to HSC myofibroblasts, which secrete extracellular matrix proteins responsible for the fibrotic scar. There are currently no therapies to directly inhibit hepatic fibrosis. We developed a small molecule screen to identify compounds that inactivate human HSC myofibroblasts through the quantification of lipid droplets. We screened 1600 compounds and identified 21 small molecules that induce HSC inactivation...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28295283/novel-colon-cancer-susceptibility-variants-identified-from-a-genome-wide-association-study-in-african-americans
#5
Hansong Wang, Stephanie L Schmit, Christopher A Haiman, Temitope O Keku, Ikuko Kato, Julie R Palmer, David van den Berg, Lynne R Wilkens, Terrilea Burnett, David V Conti, Fredrick R Schumacher, Lisa B Signorello, William J Blot, Krista A Zanetti, Curtis Harris, Mala Pande, Sonja I Berndt, Polly A Newcomb, Dee W West, Robert Haile, Daniel O Stram, Jane C Figueiredo, Loïc Le Marchand
Genome-wide association studies (GWAS) in ethnic/racial minority populations can help to fine-map previously identified risk regions or discover new risk loci because of the genetic diversity in these populations. We conducted a GWAS of colorectal cancer (CRC) in 6,597 African Americans (1,894 cases and 4,703 controls) (Stage 1) and followed up the most promising markers in a replication set of 2,041 participants of African descent (891 cases and 1,150 controls) (Stage 2). We identified a novel variant, rs56848936 in the gene SYMPK at 19q13...
March 13, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28293679/research-conference-summary-from-the-2014-international-task-force-on-atp1a3-related-disorders
#6
Hendrik Rosewich, Matthew T Sweney, Suzanne DeBrosse, Kevin Ess, Laurie Ozelius, Eva Andermann, Frederick Andermann, Gene Andrasco, Alice Belgrade, Allison Brashear, Sharon Ciccodicola, Lynn Egan, Alfred L George, Aga Lewelt, Joshua Magelby, Mario Merida, Tara Newcomb, Vicky Platt, Dominic Poncelin, Sandra Reyna, Masayuki Sasaki, Marcio Sotero de Menezes, Kathleen Sweadner, Louis Viollet, Mary Zupanc, Kenneth Silver, Kathryn Swoboda
OBJECTIVE: ATP1A3-related neurologic disorders encompass a broad range of phenotypes that extend well beyond initial phenotypic criteria associated with alternating hemiplegia of childhood (AHC) and rapid-onset dystonia parkinsonism. METHODS: In 2014, the Alternating Hemiplegia of Childhood Foundation hosted a multidisciplinary workshop intended to address fundamental challenges surrounding the diagnosis and management of individuals with ATP1A3-related disorders...
April 2017: Neurology. Genetics
https://www.readbyqxmd.com/read/28285237/an-adaptive-cue-combination-model-of-human-spatial-reorientation
#7
Yang Xu, Terry Regier, Nora S Newcombe
Previous research has proposed an adaptive cue combination view of the development of human spatial reorientation (Newcombe & Huttenlocher, 2006), whereby information from multiple sources is combined in a weighted fashion in localizing a target, as opposed to being modular and encapsulated (Hermer & Spelke, 1996). However, no prior work has formalized this proposal and tested it against existing empirical data. We propose a computational model of human spatial reorientation that is motivated by probabilistic approaches to optimal perceptual cue integration (e...
March 9, 2017: Cognition
https://www.readbyqxmd.com/read/28272187/life-interrupted-the-trauma-caregiver-experience
#8
Anna B Newcomb, Robert A Hymes
Traumatic injury frequently leads to an abrupt change in physical and psychological functioning; informal caregivers play a significant role in the recovery process in the hospital and at home. The purpose of this study was to describe the range of stressors and burdens experienced by orthopedic trauma family caregivers in the acute care setting, as well as responses and strategies employed. Qualitative, in-depth interviews were conducted in the hospital with 12 family caregivers of severely injured orthopedic trauma patients...
March 2017: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/28269711/improving-odorant-chemical-class-prediction-with-multi-layer-perceptrons-using-temporal-odorant-spike-responses-from-drosophila-melanogaster-olfactory-receptor-neurons
#9
Luqman R Bachtiar, Richard D Newcomb, Andrew V Kralicek, Charles P Unsworth
In this work, we examine the possibility of improving the prediction performance of an olfactory biosensor through the use of temporal spiking data. We present an Artificial Neural Network (ANN), in the form of an optimal hybrid Multi-Layer Perceptron (MLP) system for the classification of chemical odorants from olfactory receptor neuron spike responses of the Drosophila melanogaster fruit fly (DmOrs). The data used in this study contains the responses to 34 odorants from 6 individual DmOrs, of which we exploit the temporal spiking responses of a 500ms odorant stimulus window...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28256097/the-ontogeny-of-relational-memory-and-pattern-separation
#10
Chi T Ngo, Nora S Newcombe, Ingrid R Olson
Episodic memory relies on memory for the relations among multiple elements of an event and the ability to discriminate among similar elements of episodes. The latter phenomenon, termed pattern separation, has been studied mainly in young and older adults with relatively little research on children. Building on prior work with young children, we created an engaging computer-administered relational memory task assessing what-where relations. We also modified the Mnemonic Similarity Task used to assess pattern discrimination in young and older adults for use with preschool children...
March 2, 2017: Developmental Science
https://www.readbyqxmd.com/read/28254956/the-history-of-a-name-the-american-society-for-preventive-oncology-renames-its-highest-honor-the-joseph-f-fraumeni-jr-distinguished-achievement-award
#11
Polly A Newcomb, Ann B Hsing, Melissa L Bondy, Alfred I Neugut
No abstract text is available yet for this article.
March 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28251377/event-level-associations-among-drinking-motives-alcohol-consumption-and-condomless-anal-sex-in-a-sample-of-young-men-who-have-sex-with-men
#12
Brian A Feinstein, Michael E Newcomb
Young men who have sex with men (YMSM) are at increased risk for HIV and problematic alcohol use. Drinking motives are associated with alcohol use in cross-sectional studies, but their associations with alcohol use and condomless anal sex (CAS) at the event-level remain unclear. The current study examined these event-level associations in a sample of 189 YMSM who completed self-report measures on a daily or weekly basis for two months. Participants were recruited between August 2014 and April 2015 for a randomized trial designed to study behavioral reactivity in diary studies...
March 1, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28246053/increased-distance-to-a-liver-transplant-center-is-associated-with-higher-mortality-for-patients-with-chronic-liver-failure
#13
David S Goldberg, Craig Newcomb, Richard Gilroy, Gurvaneet Sahota, Anna E Wallace, James D Lewis, Scott D Halpern
No abstract text is available yet for this article.
February 27, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28239480/c-c-bond-migration-in-the-cycloisomerization-of-1-6-enynes
#14
Susan M Stevenson, Eric T Newcomb, Eric M Ferreira
A full account of our investigation of C-C bond migration in the cycloisomerization of oxygen-tethered 1,6-enynes is described. Under Pt(II) and/or Ir(I) catalysis, cyclic and acylic alkyl groups were found to undergo 1,2-shifts into metal carbenoid intermediates. Interestingly, this process does not appear to be driven by the release of ring strain, and thus provides access to large carbocyclic frameworks. The beneficial effect of CO on the Pt(II) and Ir(I) catalytic systems is also evaluated.
October 1, 2016: Organic Chemistry Frontiers: An International Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28227973/improving-odorant-chemical-class-prediction-with-multi-layer-perceptrons-using-temporal-odorant-spike-responses-from-drosophila-melanogaster-olfactory-receptor-neurons
#15
Luqman R Bachtiar, Richard D Newcomb, Andrew V Kralicek, Charles P Unsworth, Luqman R Bachtiar, Richard D Newcomb, Andrew V Kralicek, Charles P Unsworth, Charles P Unsworth, Andrew V Kralicek, Richard D Newcomb, Luqman R Bachtiar
In this work, we examine the possibility of improving the prediction performance of an olfactory biosensor through the use of temporal spiking data. We present an Artificial Neural Network (ANN), in the form of an optimal hybrid Multi-Layer Perceptron (MLP) system for the classification of chemical odorants from olfactory receptor neuron spike responses of the Drosophila melanogaster fruit fly (DmOrs). The data used in this study contains the responses to 34 odorants from 6 individual DmOrs, of which we exploit the temporal spiking responses of a 500ms odorant stimulus window...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28219897/vera-alma-sullivan
#16
Rosalind Hirst, Joyce Newcombe
No abstract text is available yet for this article.
February 20, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28205046/reproductive-factors-and-risk-of-colorectal-polyps-in-a-colonoscopy-based-study-in-western-washington-state
#17
Sheetal Hardikar, Andrea N Burnett-Hartman, Jessica Chubak, Melissa P Upton, Lee-Ching Zhu, John D Potter, Polly A Newcomb
BACKGROUND: Oral contraceptives (OC) are associated with a decreased risk of colorectal cancers; however, a recent study reported an increased risk of small colorectal adenomas associated with OC use. To determine if these results were replicable in a different study population, we investigated the relationship between OC use and other reproductive factors and risk of colorectal polyps in a case-control study in western Washington. METHODS: Study participants were 24-79-year-old female enrollees at an integrated health care system in western Washington who were diagnosed as having adenomas (n = 299), serrated polyps (n = 337), both types of polyps (n = 105) or as polyp-free controls (n = 615) through an index colonoscopy and completed a structured interview to collect reproductive history information...
March 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28194606/sexual-partner-typologies-and-the-association-between-drug-use-and-sexual-risk-behavior-among-young-men-who-have-sex-with-men
#18
Patrick Janulis, Brian A Feinstein, Gregory Phillips, Michael E Newcomb, Michelle Birkett, Brian Mustanski
Numerous partner and relationship characteristics are associated with sexual risk behavior among young men who have sex with men (YMSM), including being in a serious relationship and having older partners. However, most research in this area is limited by its reliance on variable-centered approaches. Using multilevel latent class analysis, this study identified subgroups of sexual partner types with a particular emphasis on examining whether partner type moderated the association between drug use and condomless anal sex (CAS)...
February 13, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28184430/prediction-of-overall-survival-in-stage-ii-and-iii-colon-cancer-beyond-tnm-system-a-retrospective-pooled-biomarker-study
#19
R Dienstmann, M J Mason, F A Sinicrope, A I Phipps, S Tejpar, A Nesbakken, S A Danielsen, A Sveen, D D Buchanan, M Clendenning, C Rosty, B Bot, S R Alberts, J Milburn Jessup, R A Lothe, M Delorenzi, P A Newcomb, D Sargent, J Guinney
No abstract text is available yet for this article.
February 9, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28181251/iv-results-links-between-spatial-assembly-later-spatial-skills-and-concurrent-and-later-mathematical-skills
#20
Brian N Verdine, Roberta Michnick Golinkoff, Kathy Hirsh-Pasek, Nora S Newcombe
No abstract text is available yet for this article.
March 2017: Monographs of the Society for Research in Child Development
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