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JOURNAL ARTICLE
Omar I Ramadan, Paul R Rosenbaum, Joseph G Reiter, Siddharth Jain, Alexander S Hill, Sean Hashemi, Rachel R Kelz, Lee A Fleisher, Jeffrey H Silber
BACKGROUND: Multimorbidity in surgery is common and associated with worse postoperative outcomes. However, conventional multimorbidity definitions (≥2 comorbidities) label the vast majority of older patients as multimorbid, limiting clinical usefulness. We sought to develop and validate better surgical specialty-specific multimorbidity definitions based on distinct comorbidity combinations. STUDY DESIGN: We used Medicare claims for patients aged 66-90 undergoing inpatient general, orthopaedic, or vascular surgery...
March 15, 2023: Journal of the American College of Surgeons
#22
EDITORIAL
Lee A Fleisher
No abstract text is available yet for this article.
March 2023: Anesthesiology Clinics
#23
JOURNAL ARTICLE
Douglas B Jacobs, Michelle Schreiber, Meena Seshamani, Daniel Tsai, Elizabeth Fowler, Lee A Fleisher
New England Journal of Medicine, Volume 388, Issue 9, Page 776-779, March 2023.
March 2, 2023: New England Journal of Medicine
#24
JOURNAL ARTICLE
Steven B Spivack, Li Qin, Jeph Herrin, Demetri B Goutos, Michelle Schreiber, Lee A Fleisher, Arjun B Venkatesh, Susannah Bernheim
The Centers for Medicare and Medicaid Services has been reporting hospital star ratings since 2016. Some stakeholders have criticized the star ratings methodology for not adjusting for social risk factors. We examined the relationship between 2021 star rating scores and hospitals' proportion of Medicare patients dually eligible for Medicaid. We found that, on average, hospitals caring for a greater proportion of dually eligible patients had lower star ratings, but there was significant overlap in performance among hospitals when we stratified them by quintile of dually eligible patients...
January 2023: Health Affairs
#25
JOURNAL ARTICLE
Jori E Fleisher, Madhuvanthi Suresh, Ellen C Klostermann, Jeanette Lee, Serena P Hess, Erica Myrick, Daniela Mitchem, Katheryn Woo, Brianna J Sennott, Natalie P Witek, Sarah Mitchell Chen, James C Beck, Bichun Ouyang, Jayne R Wilkinson, Deborah A Hall, Joshua Chodosh
INTRODUCTION: Family caregivers of people with advanced Parkinson's Disease (PD) are at high risk of caregiver strain, which independently predicts adverse patient outcomes. We tested the effects of one year of interdisciplinary, telehealth-enhanced home visits (IN-HOME-PD) with 16 weeks of peer mentoring on caregiver strain compared with usual care. METHODS: We enrolled homebound people with advanced PD (PWPD) and their primary caregiver as IN-HOME-PD dyads. We trained experienced PD family caregivers as peer mentors...
January 2023: Parkinsonism & related Disorders
#26
JOURNAL ARTICLE
Siddharth Jain, Paul R Rosenbaum, Joseph G Reiter, Omar I Ramadan, Alexander S Hill, Sean Hashemi, Rebecca T Brown, Rachel R Kelz, Lee A Fleisher, Jeffrey H Silber
BACKGROUND: The term "multimorbidity" identifies high-risk, complex patients and is conventionally defined as ≥2 comorbidities. However, this labels almost all older patients as multimorbid, making this definition less useful for physicians, hospitals, and policymakers. OBJECTIVE: Develop new medical condition-specific multimorbidity definitions for patients admitted with acute myocardial infarction (AMI), heart failure (HF), and pneumonia patients. We developed three medical condition-specific multimorbidity definitions as the presence of single, double, or triple combinations of comorbidities - called Qualifying Comorbidity Sets (QCSs) - associated with at least doubling the risk of 30-day mortality for AMI and pneumonia, or one-and-a-half times for HF patients, compared to typical patients with these conditions...
November 16, 2022: Journal of General Internal Medicine
#27
EDITORIAL
Lee A Fleisher
No abstract text is available yet for this article.
December 2022: Anesthesiology Clinics
#28
JOURNAL ARTICLE
Lee A Fleisher, Jonathan D Blum
No abstract text is available yet for this article.
October 12, 2022: JAMA Internal Medicine
#29
EDITORIAL
Lee A Fleisher
No abstract text is available yet for this article.
September 2022: Anesthesiology Clinics
#30
JOURNAL ARTICLE
Jori E Fleisher, Serena P Hess, Ellen C Klostermann, Jeanette Lee, Erica Myrick, Daniela Mitchem, Claire Niemet, Katheryn Woo, Brianna J Sennott, Maya Sanghvi, Natalie Witek, James C Beck, Jayne R Wilkinson, Bichun Ouyang, Deborah A Hall, Joshua Chodosh
INTRODUCTION: Homebound individuals with advanced Parkinson's disease (PD) are underrepresented in research and care. We tested the impact of interdisciplinary, telehealth-enhanced home visits (IN-HOME-PD) on patient quality of life (QoL) compared with usual care. METHODS: Nonrandomized controlled trial of quarterly, structured, telehealth-enhanced interdisciplinary home visits focused on symptom management, home safety, medication reconciliation, and psychosocial needs (ClinicalTrials...
September 2022: Parkinsonism & related Disorders
#31
EDITORIAL
Lee A Fleisher
No abstract text is available yet for this article.
June 2022: Anesthesiology Clinics
#32
JOURNAL ARTICLE
Jori Fleisher, Faizan Akram, Jeanette Lee, Ellen C Klostermann, Serena P Hess, Erica Myrick, Melissa Levin, Bichun Ouyang, Jayne Wilkinson, Deborah Hall, Joshua Chodosh
BACKGROUND: Homebound individuals with advanced Parkinson's Disease (PD) require intensive caregiving, the majority of which is provided by informal, family caregivers. PD caregiver strain is an independent risk factor for institutionalization. There are currently no effective interventions to support advanced PD caregivers. Studies in other neurologic disorders, however, have demonstrated the potential for peer mentoring interventions to improve caregiver outcomes. In the context of an ongoing trial of interdisciplinary home visits, we designed and piloted a nested trial of caregiver peer mentoring for informal caregivers of individuals with advanced PD...
April 28, 2022: JMIR Research Protocols
#33
JOURNAL ARTICLE
Larissa Nekhlyudov, Lee A Fleisher, Paul B Jacobsen
In this commentary, we provide an overview about the surge of telemedicine services during the COVID-19 pandemic, describe the cancer care continuum and existing evidence regarding the use of telemedicine across the continuum, and offer our perspective on existing opportunities to advance the use of telemedicine in clinical care, research, and policy. While research implications are relevant to an international audience, our focus pertains specifically to health care delivery and policy in the United States...
March 2022: Cancer Journal
#34
JOURNAL ARTICLE
Lee A Fleisher, Michelle Schreiber, Denise Cardo, Arjun Srinivasan
New England Journal of Medicine, Volume 386, Issue 7, Page 609-611, February 2022.
February 17, 2022: New England Journal of Medicine
#35
JOURNAL ARTICLE
Willemijn J Jansen, Olin Janssen, Betty M Tijms, Stephanie J B Vos, Rik Ossenkoppele, Pieter Jelle Visser, Dag Aarsland, Daniel Alcolea, Daniele Altomare, Christine von Arnim, Simone Baiardi, Ines Baldeiras, Henryk Barthel, Randall J Bateman, Bart Van Berckel, Alexa Pichet Binette, Kaj Blennow, Merce Boada, Henning Boecker, Michel Bottlaender, Anouk den Braber, David J Brooks, Mark A Van Buchem, Vincent Camus, Jose Manuel Carill, Jiri Cerman, Kewei Chen, Gaël Chételat, Elena Chipi, Ann D Cohen, Alisha Daniels, Marion Delarue, Mira Didic, Alexander Drzezga, Bruno Dubois, Marie Eckerström, Laura L Ekblad, Sebastiaan Engelborghs, Stéphane Epelbaum, Anne M Fagan, Yong Fan, Tormod Fladby, Adam S Fleisher, Wiesje M Van der Flier, Stefan Förster, Juan Fortea, Kristian Steen Frederiksen, Yvonne Freund-Levi, Lars Frings, Giovanni B Frisoni, Lutz Fröhlich, Tomasz Gabryelewicz, Hermann-Josef Gertz, Kiran Dip Gill, Olymbia Gkatzima, Estrella Gómez-Tortosa, Timo Grimmer, Eric Guedj, Christian G Habeck, Harald Hampel, Ron Handels, Oskar Hansson, Lucrezia Hausner, Sabine Hellwig, Michael T Heneka, Sanna-Kaisa Herukka, Helmut Hildebrandt, John Hodges, Jakub Hort, Chin-Chang Huang, Ane Juaristi Iriondo, Yoshiaki Itoh, Adrian Ivanoiu, William J Jagust, Frank Jessen, Peter Johannsen, Keith A Johnson, Ramesh Kandimalla, Elisabeth N Kapaki, Silke Kern, Lena Kilander, Aleksandra Klimkowicz-Mrowiec, William E Klunk, Norman Koglin, Johannes Kornhuber, Milica G Kramberger, Hung-Chou Kuo, Koen Van Laere, Susan M Landau, Brigitte Landeau, Dong Young Lee, Mony de Leon, Cristian E Leyton, Kun-Ju Lin, Alberto Lleó, Malin Löwenmark, Karine Madsen, Wolfgang Maier, Jan Marcusson, Marta Marquié, Pablo Martinez-Lage, Nancy Maserejian, Niklas Mattsson, Alexandre de Mendonça, Philipp T Meyer, Bruce L Miller, Shinobu Minatani, Mark A Mintun, Vincent C T Mok, Jose Luis Molinuevo, Silvia Daniela Morbelli, John C Morris, Barbara Mroczko, Duk L Na, Andrew Newberg, Flavio Nobili, Agneta Nordberg, Marcel G M Olde Rikkert, Catarina Resende de Oliveira, Pauline Olivieri, Adela Orellana, George Paraskevas, Piero Parchi, Matteo Pardini, Lucilla Parnetti, Oliver Peters, Judes Poirier, Julius Popp, Sudesh Prabhakar, Gil D Rabinovici, Inez H Ramakers, Lorena Rami, Eric M Reiman, Juha O Rinne, Karen M Rodrigue, Eloy Rodríguez-Rodriguez, Catherine M Roe, Pedro Rosa-Neto, Howard J Rosen, Uros Rot, Christopher C Rowe, Eckart Rüther, Agustín Ruiz, Osama Sabri, Jayant Sakhardande, Pascual Sánchez-Juan, Sigrid Botne Sando, Isabel Santana, Marie Sarazin, Philip Scheltens, Johannes Schröder, Per Selnes, Sang Won Seo, Dina Silva, Ingmar Skoog, Peter J Snyder, Hilkka Soininen, Marc Sollberger, Reisa A Sperling, Luisa Spiru, Yaakov Stern, Erik Stomrud, Akitoshi Takeda, Marc Teichmann, Charlotte E Teunissen, Louisa I Thompson, Jori Tomassen, Magda Tsolaki, Rik Vandenberghe, Marcel M Verbeek, Frans R J Verhey, Victor Villemagne, Sylvia Villeneuve, Jonathan Vogelgsang, Gunhild Waldemar, Anders Wallin, Åsa K Wallin, Jens Wiltfang, David A Wolk, Tzu-Chen Yen, Marzena Zboch, Henrik Zetterberg
IMPORTANCE: One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid aggregation, which can be detected by biomarkers in cerebrospinal fluid (CSF) and on positron emission tomography (PET) scans. Prevalence estimates of amyloid pathology are important for health care planning and clinical trial design. OBJECTIVE: To estimate the prevalence of amyloid abnormality in persons with normal cognition, subjective cognitive decline, mild cognitive impairment, or clinical AD dementia and to examine the potential implications of cutoff methods, biomarker modality (CSF or PET), age, sex, APOE genotype, educational level, geographical region, and dementia severity for these estimates...
March 1, 2022: JAMA Neurology
#36
JOURNAL ARTICLE
Sushila Murthy, Justin T Clapp, Randall C Burson, Lee A Fleisher, Mark D Neuman
BACKGROUND: Hip fracture often represents a major transition in patients' health, with a 1-year mortality rate between 25% and 30% and a challenging recovery course. Caring for hip fracture patients presents opportunities for goals of care discussions that include prognostic information and guidance about functional dependence. METHODS: We conducted qualitative, semi-structured interviews with 23 attending physicians involved with the care of hip fracture patients, including orthopedic surgeons, anesthesiologists, internists, and geriatricians, across 13 health systems in the United States and Canada...
January 6, 2022: Journal of the American Geriatrics Society
#37
EDITORIAL
Lee A Fleisher
No abstract text is available yet for this article.
December 2021: Anesthesiology Clinics
#38
JOURNAL ARTICLE
Justin T Clapp, Margaret L Schwarze, Lee A Fleisher
No abstract text is available yet for this article.
January 1, 2022: JAMA Surgery
#39
RANDOMIZED CONTROLLED TRIAL
Mark D Neuman, Rui Feng, Jeffrey L Carson, Lakisha J Gaskins, Derek Dillane, Daniel I Sessler, Frederick Sieber, Jay Magaziner, Edward R Marcantonio, Samir Mehta, Diane Menio, Sabry Ayad, Trevor Stone, Steven Papp, Eric S Schwenk, Nabil Elkassabany, Mitchell Marshall, J Douglas Jaffe, Charles Luke, Balram Sharma, Syed Azim, Robert A Hymes, Ki-Jinn Chin, Richard Sheppard, Barry Perlman, Joshua Sappenfield, Ellen Hauck, Mark A Hoeft, Mark Giska, Yatish Ranganath, Tiffany Tedore, Stephen Choi, Jinlei Li, M Kwesi Kwofie, Antoun Nader, Robert D Sanders, Brian F S Allen, Kamen Vlassakov, Stephen Kates, Lee A Fleisher, James Dattilo, Ann Tierney, Alisa J Stephens-Shields, Susan S Ellenberg
BACKGROUND: The effects of spinal anesthesia as compared with general anesthesia on the ability to walk in older adults undergoing surgery for hip fracture have not been well studied. METHODS: We conducted a pragmatic, randomized superiority trial to evaluate spinal anesthesia as compared with general anesthesia in previously ambulatory patients 50 years of age or older who were undergoing surgery for hip fracture at 46 U.S. and Canadian hospitals. Patients were randomly assigned in a 1:1 ratio to receive spinal or general anesthesia...
November 25, 2021: New England Journal of Medicine
#40
JOURNAL ARTICLE
Andrea L Benin, Minn M Soe, Jonathan R Edwards, Suparna Bagchi, Ruth Link-Gelles, Stephanie J Schrag, Kurt Herzer, Jennifer R Verani, Daniel Budnitz, Srinivas Nanduri, John Jernigan, Chris Edens, Radhika Gharpure, Anita Patel, Hsiu Wu, Beth C Golshir, Aaron Jaffe, Qunna Li, Arjun Srinivasan, Evan Shulman, Shari M Ling, Jean Moody-Williams, Lee A Fleisher, Daniel A Pollock, Jeneita Bell
OBJECTIVE: To evaluate if facility-level vaccination after an initial vaccination clinic was independently associated with COVID-19 incidence adjusted for other factors in January 2021 among nursing home residents. DESIGN: Ecological analysis of data from the CDC's National Healthcare Safety Network (NHSN) and from the CDC's Pharmacy Partnership for Long-Term Care Program. SETTING AND PARTICIPANTS: CMS-certified nursing homes participating in both NHSN and the Pharmacy Partnership for Long-Term Care Program...
August 13, 2021: Journal of the American Medical Directors Association
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