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Lee A Fleisher

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https://www.readbyqxmd.com/read/29762216/enhanced-recovery-after-surgery-is-it-time-to-drive-patient-reported-outcomes-through-robust-measurement
#1
Lee A Fleisher, Clifford Y Ko
No abstract text is available yet for this article.
June 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29759292/practice-management-successfully-guiding-your-group-into-the-future
#2
EDITORIAL
Lee A Fleisher
No abstract text is available yet for this article.
June 2018: Anesthesiology Clinics
https://www.readbyqxmd.com/read/29601787/prevalence-of-the-apolipoprotein-e-%C3%AE%C2%B54-allele-in-amyloid-%C3%AE-positive-subjects-across-the-spectrum-of-alzheimer-s-disease
#3
Niklas Mattsson, Colin Groot, Willemijn J Jansen, Susan M Landau, Victor L Villemagne, Sebastiaan Engelborghs, Mark M Mintun, Alberto Lleo, José Luis Molinuevo, William J Jagust, Giovanni B Frisoni, Adrian Ivanoiu, Gaël Chételat, Catarina Resende de Oliveira, Karen M Rodrigue, Johannes Kornhuber, Anders Wallin, Aleksandra Klimkowicz-Mrowiec, Ramesh Kandimella, Julius Popp, Pauline P Aalten, Dag Aarsland, Daniel Alcolea, Ina S Almdahl, Inês Baldeiras, Mark A van Buchem, Enrica Cavedo, Kewei Chen, Ann D Cohen, Stefan Förster, Juan Fortea, Kristian S Frederiksen, Yvonne Freund-Levi, Kiran Dip Gill, Olymbia Gkatzima, Timo Grimmer, Harald Hampel, Sanna-Kaisa Herukka, Peter Johannsen, Koen van Laere, Mony J de Leon, Wolfgang Maier, Jan Marcusson, Olga Meulenbroek, Hanne M Møllergård, John C Morris, Barbara Mroczko, Arto Nordlund, Sudesh Prabhakar, Oliver Peters, Lorena Rami, Eloy Rodríguez-Rodríguez, Catherine M Roe, Eckart Rüther, Isabel Santana, Johannes Schröder, Sang W Seo, Hilkka Soininen, Luiza Spiru, Erik Stomrud, Hanne Struyfs, Charlotte E Teunissen, Frans R J Verhey, Stephanie J B Vos, Linda J C van Waalwijk van Doorn, Gunhild Waldemar, Åsa K Wallin, Jens Wiltfang, Rik Vandenberghe, David J Brooks, Tormod Fladby, Christopher C Rowe, Alexander Drzezga, Marcel M Verbeek, Marie Sarazin, David A Wolk, Adam S Fleisher, William E Klunk, Duk L Na, Pascual Sánchez-Juan, Dong Young Lee, Agneta Nordberg, Magda Tsolaki, Vincent Camus, Juha O Rinne, Anne M Fagan, Henrik Zetterberg, Kaj Blennow, Gil D Rabinovici, Oskar Hansson, Bart N M van Berckel, Wiesje M van der Flier, Philip Scheltens, Pieter Jelle Visser, Rik Ossenkoppele
INTRODUCTION: Apolipoprotein E (APOE) ε4 is the major genetic risk factor for Alzheimer's disease (AD), but its prevalence is unclear because earlier studies did not require biomarker evidence of amyloid β (Aβ) pathology. METHODS: We included 3451 Aβ+ subjects (853 AD-type dementia, 1810 mild cognitive impairment, and 788 cognitively normal). Generalized estimating equation models were used to assess APOE ε4 prevalence in relation to age, sex, education, and geographical location...
March 28, 2018: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29576111/systematic-review-and-consensus-definitions-for-the-standardised-endpoints-in-perioperative-medicine-step-initiative-patient-comfort
#4
REVIEW
P S Myles, O Boney, M Botti, A M Cyna, T J Gan, M P Jensen, H Kehlet, A Kurz, G S De Oliveira, P Peyton, D I Sessler, M R Tramèr, C L Wu, Paul Myles, Michael Grocott, Bruce Biccard, Jane Blazeby, Oliver Boney, Matthew Chan, Elisabeth Diouf, Lee Fleisher, Cor Kalkman, Andrea Kurz, Ramani Moonesinghe, Duminda Wijeysundera
BACKGROUND: Maximising patient comfort during and after surgery is a primary concern of anaesthetists and other perioperative clinicians, but objective measures of what constitutes patient comfort in the perioperative period remain poorly defined. The Standardised Endpoints in Perioperative Medicine initiative was established to derive a set of standardised endpoints for use in perioperative clinical trials. METHODS: We undertook a systematic review to identify measures of patient comfort used in the anaesthetic, surgical, and other perioperative literature...
April 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29484571/effects-of-vedolizumab-therapy-on-extraintestinal-manifestations-in-inflammatory-bowel-disease
#5
REVIEW
Mark Fleisher, Jan Marsal, Scott D Lee, Laura E Frado, Alyssa Parian, Burton I Korelitz, Brian G Feagan
BACKGROUND: Approximately 15-20% of ulcerative colitis patients and 20-40% of those with Crohn's disease experience extraintestinal manifestations (EIMs) of their inflammatory bowel disease (IBD). Clinicians who treat IBD must manage EIMs affecting multiple organs that variably correlate with intestinal disease activity. Vedolizumab is a monoclonal antibody for the treatment of IBD with a gut-selective mechanism of action. AIMS: This report evaluates whether vedolizumab is an effective treatment of EIMs, given its gut-specific mechanism of action...
April 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29461263/the-role-of-feedback-in-ameliorating-burnout
#6
Emily K Gordon, Dimitry Y Baranov, Lee A Fleisher
PURPOSE OF REVIEW: Assessment of the current literature surrounding interventions directed toward the prevention of burnout in the field of medicine and particularly in anesthesiology. RECENT FINDINGS: Recently, burnout has been noted to lead to medication errors and subsequently increased harm to our patients. On a personal level, burnout can lead to depression and even suicide amongst physicians. Strategies to prevent burnout amongst anesthesiologists that have been studied in the literature include multisource feedback, mentorship and early recognition...
June 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29425604/quality-improvement-and-implementation-science-different-fields-with-aligned-goals
#7
EDITORIAL
Meghan B Lane-Fall, Lee A Fleisher
No abstract text is available yet for this article.
March 2018: Anesthesiology Clinics
https://www.readbyqxmd.com/read/29425603/improving-perioperative-care-what-are-the-tools-that-lead-to-sustainable-change
#8
EDITORIAL
Lee A Fleisher
No abstract text is available yet for this article.
March 2018: Anesthesiology Clinics
https://www.readbyqxmd.com/read/29389750/18f-florbetapir-positron-emission-tomography-determined-cerebral-%C3%AE-amyloid-deposition-and-neurocognitive-performance-after-cardiac-surgery
#9
Rebecca Y Klinger, Olga G James, Salvador Borges-Neto, Tiffany Bisanar, Yi-Ju Li, Wenjing Qi, Miles Berger, Niccolò Terrando, Mark F Newman, P Murali Doraiswamy, Joseph P Mathew
BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively. METHODS: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and 1 yr (n = 12); neurocognitive function was assessed at baseline (n = 40), 6 weeks (n = 37), 1 yr (n = 13), and 3 yr (n = 9)...
April 2018: Anesthesiology
https://www.readbyqxmd.com/read/29240006/surgical-consultation-as-social-process-implications-for-shared-decision-making
#10
Justin T Clapp, Alexander F Arriaga, Sushila Murthy, Steven E Raper, J Sanford Schwartz, Frances K Barg, Lee A Fleisher
OBJECTIVE: This qualitative study examines surgical consultation as a social process and assesses its alignment with assumptions of the shared decision-making (SDM) model. SUMMARY OF BACKGROUND DATA: SDM stresses the importance of patient preferences and rigorous discussion of therapeutic risks/benefits based on these preferences. However, empirical studies have highlighted discrepancies between SDM and realities of surgical decision making. Qualitative research can inform understanding of the decision-making process and allow for granular assessment of the nature and causes of these discrepancies...
December 12, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/29238829/the-role-of-gabapentin-in-multimodal-postoperative-pain-management
#11
Michael A Ashburn, Lee A Fleisher
No abstract text is available yet for this article.
December 13, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29188296/association-of-cerebral-amyloid-%C3%AE-aggregation-with-cognitive-functioning-in-persons-without-dementia
#12
Willemijn J Jansen, Rik Ossenkoppele, Betty M Tijms, Anne M Fagan, Oskar Hansson, William E Klunk, Wiesje M van der Flier, Victor L Villemagne, Giovanni B Frisoni, Adam S Fleisher, Alberto Lleó, Mark A Mintun, Anders Wallin, Sebastiaan Engelborghs, Duk L Na, Gäel Chételat, José Luis Molinuevo, Susan M Landau, Niklas Mattsson, Johannes Kornhuber, Osama Sabri, Christopher C Rowe, Lucilla Parnetti, Julius Popp, Tormod Fladby, William J Jagust, Pauline Aalten, Dong Young Lee, Rik Vandenberghe, Catarina Resende de Oliveira, Elisabeth Kapaki, Lutz Froelich, Adrian Ivanoiu, Tomasz Gabryelewicz, Marcel M Verbeek, Páscual Sanchez-Juan, Helmut Hildebrandt, Vincent Camus, Marzena Zboch, David J Brooks, Alexander Drzezga, Juha O Rinne, Andrew Newberg, Alexandre de Mendonça, Marie Sarazin, Gil D Rabinovici, Karine Madsen, Milica G Kramberger, Agneta Nordberg, Vincent Mok, Barbara Mroczko, David A Wolk, Philipp T Meyer, Magda Tsolaki, Philip Scheltens, Frans R J Verhey, Pieter Jelle Visser, Dag Aarsland, Daniel Alcolea, Myriam Alexander, Ina S Almdahl, Steven E Arnold, Inês Baldeiras, Henryk Barthel, Bart N M van Berckel, Kaj Blennow, Mark A van Buchem, Enrica Cavedo, Kewei Chen, Elena Chipi, Ann D Cohen, Stefan Förster, Juan Fortea, Kristian S Frederiksen, Yvonne Freund-Levi, Olymbia Gkatzima, Mark Forrest Gordon, Timo Grimmer, Harald Hampel, Lucrezia Hausner, Sabine Hellwig, Sanna-Kaisa Herukka, Peter Johannsen, Aleksandra Klimkowicz-Mrowiec, Sebastian Köhler, Norman Koglin, Koen van Laere, Mony de Leon, Viviana Lisetti, Wolfgang Maier, Jan Marcusson, Olga Meulenbroek, Hanne M Møllergård, John C Morris, Arto Nordlund, Gerald P Novak, George P Paraskevas, Gayan Perera, Oliver Peters, Inez H G B Ramakers, Lorena Rami, Eloy Rodríguez-Rodríguez, Catherine M Roe, Uros Rot, Eckart Rüther, Isabel Santana, Johannes Schröder, Sang W Seo, Hilkka Soininen, Luiza Spiru, Erik Stomrud, Hanne Struyfs, Charlotte E Teunissen, Stephanie J B Vos, Linda J C van Waalwijk van Doorn, Gunhild Waldemar, Åsa K Wallin, Jens Wiltfang, Henrik Zetterberg
Importance: Cerebral amyloid-β aggregation is an early event in Alzheimer disease (AD). Understanding the association between amyloid aggregation and cognitive manifestation in persons without dementia is important for a better understanding of the course of AD and for the design of prevention trials. Objective: To investigate whether amyloid-β aggregation is associated with cognitive functioning in persons without dementia. Design, Setting, and Participants: This cross-sectional study included 2908 participants with normal cognition and 4133 with mild cognitive impairment (MCI) from 53 studies in the multicenter Amyloid Biomarker Study...
January 1, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29109193/the-value-of-preoperative-assessment-before-noncardiac-surgery-in-the-era-of-value-based-care
#13
Lee A Fleisher
No abstract text is available yet for this article.
November 7, 2017: Circulation
https://www.readbyqxmd.com/read/29101962/anesthesia-outside-of-the-operating-room-the-wild-west-or-the-new-frontier
#14
EDITORIAL
Lee A Fleisher
No abstract text is available yet for this article.
December 2017: Anesthesiology Clinics
https://www.readbyqxmd.com/read/28930765/encouraging-reflexivity-in-a-residency-leadership-development-program-expanding-outside-the-competency-approach
#15
Justin T Clapp, Emily K B Gordon, Dimitry Y Baranov, Beulah Trey, Felice J Tilin, Lee A Fleisher
PROBLEM: While leadership development is increasingly a goal of academic medicine, it is typically framed as competency acquisition, which can limit its focus to a circumscribed set of social behaviors. This orientation may also reinforce the cultural characteristics of academic medicine that can make effective leadership difficult, rather than training leaders capable of examining and changing this culture. Expanding leadership development so it promotes social reflexivity presents a way to bolster some of the weaknesses of the competency paradigm...
February 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28819021/phenotypic-heterogeneity-of-circulating-tumor-cells-informs-clinical-decisions-between-ar-signaling-inhibitors-and-taxanes-in-metastatic-prostate-cancer
#16
Howard I Scher, Ryon P Graf, Nicole A Schreiber, Brigit McLaughlin, Adam Jendrisak, Yipeng Wang, Jerry Lee, Stephanie Greene, Rachel Krupa, David Lu, Pascal Bamford, Jessica E Louw, Lyndsey Dugan, Hebert A Vargas, Martin Fleisher, Mark Landers, Glenn Heller, Ryan Dittamore
The heterogeneity of an individual patient's tumor has been linked to treatment resistance, but quantitative biomarkers to rapidly and reproducibly evaluate heterogeneity in a clinical setting are currently lacking. Using established tools available in a College of American Pathologists-accredited and Clinical Laboratory Improvement Amendments-certified clinical laboratory, we quantified digital pathology features on 9,225 individual circulating tumor cells (CTC) from 179 unique metastatic castration-resistant prostate cancer (mCRPC) patients to define phenotypically distinct cell types...
October 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28661969/structural-nursing-and-physician-characteristics-and-30-day-mortality-for-patients-undergoing-cardiac-surgery-in-pennsylvania
#17
MULTICENTER STUDY
Meghan B Lane-Fall, Tara S Ramaswamy, Sydney E S Brown, Xu He, Jacob T Gutsche, Lee A Fleisher, Mark D Neuman
OBJECTIVE: Cardiac surgery ICU characteristics and clinician staffing patterns have not been well characterized. We sought to describe Pennsylvania cardiac ICUs and to determine whether ICU characteristics are associated with mortality in the 30 days after cardiac surgery. DESIGN: From 2012 to 2013, we conducted a survey of cardiac surgery ICUs in Pennsylvania to assess ICU structure, care practices, and clinician staffing patterns. ICU data were linked to an administrative database of cardiac surgery patient discharges...
September 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28632541/hospital-based-acute-care-within-7-days-of-discharge-after-outpatient-arthroscopic-shoulder-surgery
#18
Jiabin Liu, David N Flynn, Wai-Man Liu, Lee A Fleisher, Nabil M Elkassabany
BACKGROUND: The rate of hospital-based acute care (defined as hospital transfer at discharge, emergency department [ED] visit, or subsequent inpatient hospital [IP] admission) after outpatient procedure is gaining momentum as a quality metric for ambulatory surgery. However, the incidence and reasons for hospital-based acute care after arthroscopic shoulder surgery are poorly understood. METHODS: We studied adult patients who underwent outpatient arthroscopic shoulder procedures in New York State between 2011 and 2013 using the Healthcare Cost and Utilization Project database...
February 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28526165/pharmacology
#19
EDITORIAL
Lee A Fleisher
No abstract text is available yet for this article.
June 2017: Anesthesiology Clinics
https://www.readbyqxmd.com/read/28494710/2016-aha-acc-guideline-on-the-management-of-patients-with-lower-extremity-peripheral-artery-disease-executive-summary
#20
Marie D Gerhard-Herman, Heather L Gornik, Coletta Barrett, Neal R Barshes, Matthew A Corriere, Douglas E Drachman, Lee A Fleisher, Francis Gerry R Fowkes, Naomi M Hamburg, Scott Kinlay, Robert Lookstein, Sanjay Misra, Leila Mureebe, Jeffrey W Olin, Rajan A G Patel, Judith G Regensteiner, Andres Schanzer, Mehdi H Shishehbor, Kerry J Stewart, Diane Treat-Jacobson, M Eileen Walsh, Jonathan L Halperin, Glenn N Levine, Sana M Al-Khatib, Kim K Birtcher, Biykem Bozkurt, Ralph G Brindis, Joaquin E Cigarroa, Lesley H Curtis, Lee A Fleisher, Federico Gentile, Samuel Gidding, Mark A Hlatky, John Ikonomidis, José Joglar, Susan J Pressler, Duminda N Wijeysundera
No abstract text is available yet for this article.
June 2017: Vascular Medicine
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