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Michael A Ashburn

Michael A Ashburn
No abstract text is available yet for this article.
July 2016: Pharmacoepidemiology and Drug Safety
Perry G Fine, Michael A Ashburn
No abstract text is available yet for this article.
June 2016: Anesthesiology Clinics
Michael A Ashburn, Lee A Fleisher
No abstract text is available yet for this article.
March 2016: Healthcare
Peter Pryzbylkowski, Michael A Ashburn
Chronic pain affects an estimated 100 million people a year in the United States and costs society anywhere from $560 to $635 billion annually. The patient-centered medical home and the patient-centered medical home-neighbor models of care have been advocated to improve patient outcomes. These models of care advocate improved coordination of care within the primary care and specialty care setting. The authors present the patient-centered medical home model of care and suggest how this model of care might be used to improve patient outcomes for patients with chronic pain...
December 2015: Anesthesiology Clinics
Alexander Chen, Michael A Ashburn
OBJECTIVE: The use of opioids to treat chronic pain has come under increased scrutiny, as such use has been associated with significant risk of death, with limited data regarding the long-term effectiveness, especially when used to treat noncancer pain. The purpose of this manuscript is to discuss the cardiac effects associated with long-term opioid therapy. DESIGN: A literature search was performed using OVID. RESULTS: Most opioids have little direct negative effect on cardiac contractility...
October 2015: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Jennifer S Gewandter, Robert H Dworkin, Dennis C Turk, John T Farrar, Roger B Fillingim, Ian Gilron, John D Markman, Anne Louise Oaklander, Michael J Polydefkis, Srinivasa N Raja, James P Robinson, Clifford J Woolf, Dan Ziegler, Michael A Ashburn, Laurie B Burke, Penney Cowan, Steven Z George, Veeraindar Goli, Ole X Graff, Smriti Iyengar, Gary W Jay, Joel Katz, Henrik Kehlet, Rachel A Kitt, Ernest A Kopecky, Richard Malamut, Michael P McDermott, Pamela Palmer, Bob A Rappaport, Christine Rauschkolb, Ilona Steigerwald, Jeffrey Tobias, Gary A Walco
Although certain risk factors can identify individuals who are most likely to develop chronic pain, few interventions to prevent chronic pain have been identified. To facilitate the identification of preventive interventions, an IMMPACT meeting was convened to discuss research design considerations for clinical trials investigating the prevention of chronic pain. We present general design considerations for prevention trials in populations that are at relatively high risk for developing chronic pain. Specific design considerations included subject identification, timing and duration of treatment, outcomes, timing of assessment, and adjusting for risk factors in the analyses...
July 2015: Pain
Samuel Grodofsky, Emmanuel Edson, Stephanie Huang, Rebecca M Speck, Justin Hatchimonji, Kim Lacy, John T Farrar, Michael A Ashburn
OBJECTIVE: Methadone is associated with QT prolongation and serious cardiac complications, but this has been primarily demonstrated in opioid dependent patients receiving moderate to high doses. This study investigates the effect of low-dose methadone on the QTc interval in a chronic pain population. DESIGN AND SUBJECTS: We conducted a prospective cohort study in a chronic pain clinic including 82 patients receiving methadone and 102 patients receiving non-methadone opioid therapy...
June 2015: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Andrew R Deans, Suzanna E Lewis, Eva Huala, Salvatore S Anzaldo, Michael Ashburner, James P Balhoff, David C Blackburn, Judith A Blake, J Gordon Burleigh, Bruno Chanet, Laurel D Cooper, Mélanie Courtot, Sándor Csösz, Hong Cui, Wasila Dahdul, Sandip Das, T Alexander Dececchi, Agnes Dettai, Rui Diogo, Robert E Druzinsky, Michel Dumontier, Nico M Franz, Frank Friedrich, George V Gkoutos, Melissa Haendel, Luke J Harmon, Terry F Hayamizu, Yongqun He, Heather M Hines, Nizar Ibrahim, Laura M Jackson, Pankaj Jaiswal, Christina James-Zorn, Sebastian Köhler, Guillaume Lecointre, Hilmar Lapp, Carolyn J Lawrence, Nicolas Le Novère, John G Lundberg, James Macklin, Austin R Mast, Peter E Midford, István Mikó, Christopher J Mungall, Anika Oellrich, David Osumi-Sutherland, Helen Parkinson, Martín J Ramírez, Stefan Richter, Peter N Robinson, Alan Ruttenberg, Katja S Schulz, Erik Segerdell, Katja C Seltmann, Michael J Sharkey, Aaron D Smith, Barry Smith, Chelsea D Specht, R Burke Squires, Robert W Thacker, Anne Thessen, Jose Fernandez-Triana, Mauno Vihinen, Peter D Vize, Lars Vogt, Christine E Wall, Ramona L Walls, Monte Westerfeld, Robert A Wharton, Christian S Wirkner, James B Woolley, Matthew J Yoder, Aaron M Zorn, Paula Mabee
Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that has been made to accurately capture relevant data descriptions for phenotypes...
January 2015: PLoS Biology
Richard W Grant, Jeffrey M Ashburner, Michael C Jernigan, Jaime Chang, Leila H Borowsky, Yuchiao Chang, Steven J Atlas
BACKGROUND: Lack of timely medication intensification and inadequate medication safety monitoring are two prevalent and potentially modifiable barriers to effective and safe chronic care. Innovative applications of health information technology tools may help support chronic disease management. OBJECTIVE: To examine the clinical impact of a novel health IT tool designed to facilitate between-visit ordering and tracking of future laboratory testing. DESIGN AND PARTICIPANTS: Clinical trial randomized at the provider level (n = 44 primary care physicians); patient-level outcomes among 3,655 primary care patients prescribed 5,454 oral medicines for hyperlipidemia, diabetes, and/or hypertension management over a 12-month period...
May 2015: Journal of General Internal Medicine
Sy-Yeu S Chern, Rebecca Isserman, Linda Chen, Michael Ashburn, Renyu Liu
Here we present a patient with a Type I Chiari malformation who was receiving buprenorphine for chronic pain who underwent two separate urogynecologic procedures for removal of vaginal mesh with two different pain management regimens. For the first procedure at an outside hospital, the patient's usual dose of buprenorphine (8 mg sublingual every 8 hours) was continued up through her surgery and then a full opioid receptor agonist was used for postoperative pain management. The patient complained that this resulted in very poor pain control for her in the postoperative period...
October 30, 2013: Journal of Anesthesia & Clinical Research
Takeshi Q Tanaka, Edgar Deu, Alvaro Molina-Cruz, Michael J Ashburne, Omar Ali, Amreena Suri, Sandhya Kortagere, Matthew Bogyo, Kim C Williamson
The Plasmodium falciparum and P. berghei genomes each contain three dipeptidyl aminopeptidase (dpap) homologs. dpap1 and -3 are critical for asexual growth, but the role of dpap2, the gametocyte-specific homolog, has not been tested. If DPAPs are essential for transmission as well as asexual growth, then a DPAP inhibitor could be used for treatment and to block transmission. To directly analyze the role of DPAP2, a dpap2-minus P. berghei (Pbdpap2Δ) line was generated. The Pbdpap2Δ parasites grew normally, differentiated into gametocytes, and generated sporozoites that were infectious to mice when fed to a mosquito...
October 2013: Antimicrobial Agents and Chemotherapy
Lisa R Witkin, Dina Diskina, Shawn Fernandes, John T Farrar, Michael A Ashburn
OBJECTIVE: The purpose of this study was to determine if the opioid risk tool (ORT) was clinically useful in guiding physician decision making during chronic opioid therapy and to determine whether there were differences between the patient-completed and physician-completed ORT. DESIGN: Retrospective review of prospectively collected data. SETTING: A single-center tertiary care outpatient pain management center. PATIENTS, PARTICIPANTS: One-hundred twenty-five patients who received chronic opioids as part of their pain therapy...
May 2013: Journal of Opioid Management
Lisa R Witkin, John T Farrar, Michael A Ashburn
OBJECTIVE: This manuscript reviews how patient-reported outcomes data can be used to guide efforts to improve patient outcomes. DESIGN: Review Manuscript. SETTING: The clinical management of chronic, non-cancer pain. SUBJECTS: Adult patients receiving treatment for chronic, non-cancer pain. RESULTS: While there have been great advances in the science of pain and various therapeutic medications and interventions, patient outcomes are variable...
June 2013: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
Michael Ashburn
No abstract text is available yet for this article.
February 2012: Clinical Drug Investigation
Steven J Atlas, Jeffrey M Ashburner, Yuchiao Chang, William T Lester, Michael J Barry, Richard W Grant
OBJECTIVES: To assess the ability of a health information technology system to facilitate population- based breast cancer screening. STUDY DESIGN: Cohort study with 2-year follow-up after a 1-year cluster randomized trial. METHODS: Study population was women 42 to 69 years old receiving care within a 12-practice primary care network. The management informatics system (1) identified women overdue for mammograms, (2) connected them to primary care providers using a web-based tool, (3) created automatically generated outreach letters for patients specified by providers, (4) monitored for subsequent mammography scheduling and completion, and (5) provided practice delegates with a list of women remaining unscreened for reminder phone calls...
December 2012: American Journal of Managed Care
Melissa L McIntosh, Michael R Naffziger, Bradley O Ashburn, Lev N Zakharov, Rich G Carter
The dipolar cycloadditions of ortho-nitrophenyl alkynes with aryl nitrile oxides has been demonstrated. A range of substituents are tolerated on the alkyne. These reactions proceed with excellent levels of regioselectivity. Subsequent functionalization of the isoxazole scaffold has been demonstrated.
December 14, 2012: Organic & Biomolecular Chemistry
Ronald J Hill, Isabelle M L Billas, François Bonneton, Lloyd D Graham, Michael C Lawrence
In 1974, Ashburner and colleagues postulated a model to explain the control of the puffing sequence on Drosophila polytene chromosomes initiated by the molting hormone 20-hydroxyecdysone. This model inspired a generation of molecular biologists to clone and characterize elements of the model, thereby providing insights into the control of gene networks by steroids, diatomic gases, and other small molecules. It led to the first cloning of the EcR subunit of the heterodimeric EcR-USP ecdysone receptor. X-ray diffraction studies of the ligand-binding domain of the receptor are elucidating the specificity of receptor-ecdysteroid interactions, the selectivity of some environmentally friendly insecticides, the evolution of the EcR-USP heterodimer, and indeed Ashburner's classical biochemical evidence for the central role of the ecdysone receptor in his model...
2013: Annual Review of Entomology
Michael A Ashburn, Lisa Witkin
No abstract text is available yet for this article.
August 2012: Pain
Jean-Baptiste Poline, Janis L Breeze, Satrajit Ghosh, Krzysztof Gorgolewski, Yaroslav O Halchenko, Michael Hanke, Christian Haselgrove, Karl G Helmer, David B Keator, Daniel S Marcus, Russell A Poldrack, Yannick Schwartz, John Ashburner, David N Kennedy
Significant resources around the world have been invested in neuroimaging studies of brain function and disease. Easier access to this large body of work should have profound impact on research in cognitive neuroscience and psychiatry, leading to advances in the diagnosis and treatment of psychiatric and neurological disease. A trend toward increased sharing of neuroimaging data has emerged in recent years. Nevertheless, a number of barriers continue to impede momentum. Many researchers and institutions remain uncertain about how to share data or lack the tools and expertise to participate in data sharing...
2012: Frontiers in Neuroinformatics
Babak Sarani, Samir Mehta, Michael Ashburn, Koji Nakashima, Rajan Gupta, Derek Dombroski, C William Schwab
The global response to the 12 January 2010 earthquake in Haiti revealed the ability to mobilise medical teams quickly and effectively when academic medical centres partner non-governmental organisations (NGO) that already have a presence in a zone of devastation. Most established NGOs based in a certain region are accustomed to managing the medical conditions that are common to that area and will need additional and specialised support to treat the flux of myriad injured persons. Furthermore, an NGO with an established presence in a region prior to a disaster appears better positioned to provide sustained recovery and rehabilitation relief...
October 2012: Disasters
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