keyword
MENU ▼
Read by QxMD icon Read
search

Rapid deployment

keyword
https://www.readbyqxmd.com/read/28317856/a-smartphone-based-diagnostic-platform-for-rapid-detection-of-zika-chikungunya-and-dengue-viruses
#1
Aashish Priye, Sara W Bird, Yooli K Light, Cameron S Ball, Oscar A Negrete, Robert J Meagher
Current multiplexed diagnostics for Zika, dengue, and chikungunya viruses are situated outside the intersection of affordability, high performance, and suitability for use at the point-of-care in resource-limited settings. Consequently, insufficient diagnostic capabilities are a key limitation facing current Zika outbreak management strategies. Here we demonstrate highly sensitive and specific detection of Zika, chikungunya, and dengue viruses by coupling reverse-transcription loop-mediated isothermal amplification (RT-LAMP) with our recently developed quenching of unincorporated amplification signal reporters (QUASR) technique...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28315616/counterfactual-simulations-applied-to-shrp2-crashes-the-effect-of-driver-behavior-models-on-safety-benefit-estimations-of-intelligent-safety-systems
#2
Jonas Bärgman, Christian-Nils Boda, Marco Dozza
As the development and deployment of in-vehicle intelligent safety systems (ISS) for crash avoidance and mitigation have rapidly increased in the last decades, the need to evaluate their prospective safety benefits before introduction has never been higher. Counterfactual simulations using relevant mathematical models (for vehicle dynamics, sensors, the environment, ISS algorithms, and models of driver behavior) have been identified as having high potential. However, although most of these models are relatively mature, models of driver behavior in the critical seconds before a crash are still relatively immature...
March 15, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28302675/receptor-kinases-in-plant-pathogen-interactions-more-than-pattern-recognition
#3
Jian-Min Zhou, Dingzhong Tang, Guoxun Wang
Receptor-Like Kinases (RLKs) and Receptor-Like Proteins (RLPs) play crucial roles in plant immunity, growth and development. Plants deploy a large number of RLKs and RLPs as Pattern Recognition Receptors (PRRs) to detect microbe- and host-derived molecular patterns, as the first line of defense. Recent advances have uncovered new PRRs, their corresponding ligands, and mechanisms underlying PRR activation and signaling. In general, PRRs associate with other RLKs and function as part of multi-protein immune complexes at the cell surface...
March 16, 2017: Plant Cell
https://www.readbyqxmd.com/read/28296456/improving-patient-safety-through-the-use-of-nursing-surveillance
#4
Karen K Giuliano
Surveillance and monitoring each represent a distinct process in patient care. Monitoring involves observation, measurement, and recording of physiological parameters, while surveillance is a systematic, goal-directed process based on early detection of signs of change, interpretation of the clinical implications of such changes, and initiation of rapid, appropriate interventions. Through use of an illustrative clinical example based on Early Warning System scoring and rapid response teams, this article seeks to distinguish between nurse monitoring and surveillance to demonstrate the impact of surveillance on improving both care processes and patient care...
February 2017: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/28295938/alkenyl-isocyanide-conjugate-additions-a-rapid-route-to-%C3%AE-carbolines
#5
Sergiy V Chepyshev, J Armando Lujan-Montelongo, Allen Chao, Fraser F Fleming
Isocyanides are exceptional building blocks, the wide deployment of which in multicomponent and metal-insertion reactions belies their limited availability. The first conjugate addition/alkylation to alkenyl isocyanides is described, which addresses this deficiency. An array of organolithiums, magnesiates, enolates, and metalated nitriles add conjugately to β- and β,β-disubstituted arylsulfonyl alkenyl isocyanides to rapidly assemble diverse isocyanide scaffolds. The intermediate metalated isocyanides are efficiently trapped with electrophiles to generate substituted isocyanides incorporating contiguous tri- and tetra-substituted centers...
March 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28291501/lateral-flow-rapid-test-for-accurate-and-early-diagnosis-of-scrub-typhus-a-febrile-illness-of-historically-military-importance-in-the-pacific-rim
#6
Chien-Chung Chao, Zhiwen Zhangm, Giulia Weissenberger, Hua-Wei Chen, Wei-Mei Ching
Scrub typhus (ST) is an infection caused by Orientia tsutsugamushi. Historically, ST was ranked as the second most important arthropod-borne medical problem only behind malaria during World War II and the Vietnam War. The disease occurs mainly in Southeast Asia and has been shown to emerge and reemerge in new areas, implying the increased risk for U.S. military and civilian personnel deployed to these regions. ST can effectively be treated by doxycycline provided the diagnosis is made early, before the development of severe complications...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28291496/public-health-surveillance-via-template-management-in-electronic-health-records-tri-service-workflow-s-rapid-response-to-an-infectious-disease-crisis
#7
Holly Berkley, Matthew Barnes, David Carnahan, Janet Hayhurst, Archie Bockhorst, James Neville
OBJECTIVE: To describe the use of template-based screening for risk of infectious disease exposure of patients presenting to primary care medical facilities during the 2014 West African Ebola virus outbreak. METHODS: The Military Health System implemented an Ebola risk-screening tool in primary care settings in order to create early notifications and early responses to potentially infected persons. Three time-sensitive, evidence-based screening questions were developed and posted to Tri-Service Workflow (TSWF) AHLTA templates in conjunction with appropriate training...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28288887/transapical-endovascular-repair-of-thoracic-aortic-pathology
#8
Takashi Murakami, Shinsuke Nishimura, Mitsuharu Hosono, Yoshitsugu Nakamura, Etsuji Sohgawa, Yukimasa Sakai, Toshihiko Shibata
BACKGROUND: Alternative access for thoracic endovascular aortic repair (TEVAR) has been explored for patients with unsuitable femoral and iliac access, but few cases of transapical access have been described. We report our experience with transapical access for various aortic pathologies. METHODS: We reviewed six cases undergoing transapical access for endovascular repair of thoracic aortic pathology between December 2013 and August 2015. Five patients had an aortic arch aneurysm and 1 patient presented with Stanford type A subacute aortic dissection...
March 10, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28288655/effect-of-an-automated-notification-system-for-deteriorating-ward-patients-on-clinical-outcomes
#9
Christian P Subbe, Bernd Duller, Rinaldo Bellomo
BACKGROUND: Delayed response to clinical deterioration of ward patients is common. METHODS: We performed a prospective before-and-after study in all patients admitted to two clinical ward areas in a district general hospital in the UK. We examined the effect on clinical outcomes of deploying an electronic automated advisory vital signs monitoring and notification system, which relayed abnormal vital signs to a rapid response team (RRT). RESULTS: We studied 2139 patients before (control) and 2263 after the intervention...
March 14, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28282962/a-novel-topology-link-controlling-approach-for-active-defense-of-a-node-in-a-network
#10
Jun Li, HanPing Hu, Qiao Ke, Naixue Xiong
With the rapid development of virtual machine technology and cloud computing, distributed denial of service (DDoS) attacks, or some peak traffic, poses a great threat to the security of the network. In this paper, a novel topology link control technique and mitigation attacks in real-time environments is proposed. Firstly, a non-invasive method of deploying virtual sensors in the nodes is built, which uses the resource manager of each monitored node as a sensor. Secondly, a general topology-controlling approach of resisting the tolerant invasion is proposed...
March 9, 2017: Sensors
https://www.readbyqxmd.com/read/28282646/point-of-care-sexually-transmitted-infection-diagnostics-proceedings-of-the-star-sexually-transmitted-infection-clinical-trial-group-programmatic-meeting
#11
Anthony D Cristillo, Claire C Bristow, Rosanna Peeling, Barbara Van Der Pol, Sasha Herbst de Cortina, Ivan K Dimov, Nitika Pant Pai, Dong Jin Shin, Ricky Y T Chiu, Catherine Klapperich, Purnima Madhivanan, Sheldon R Morris, Jeffrey D Klausner
The goal of the point-of-care (POC) sexually transmitted infection (STI) Diagnostics meeting was to review the state-of-the-art research and develop recommendations for the use of POC STI diagnostics. Experts from academia, government, nonprofit, and industry discussed POC diagnostics for STIs such as Chlamydia trachomatis, human papillomavirus, Neisseria gonorrhoeae, Trichomonas vaginalis, and Treponema pallidum. Key objectives included a review of current and emerging technologies, clinical and public health benefits, POC STI diagnostics in developing countries, regulatory considerations, and future areas of development...
April 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28275817/discovery-and-characterization-of-two-new-stem-rust-resistance-genes-in-aegilops-sharonensis
#12
Guotai Yu, Nicolas Champouret, Burkhard Steuernagel, Pablo D Olivera, Jamie Simmons, Cole Williams, Ryan Johnson, Matthew J Moscou, Inmaculada Hernández-Pinzón, Phon Green, Hanan Sela, Eitan Millet, Jonathan D G Jones, Eric R Ward, Brian J Steffenson, Brande B H Wulff
We identified two novel wheat stem rust resistance genes, Sr-1644-1Sh and Sr-1644-5Sh in Aegilops sharonensis that are effective against widely virulent African races of the wheat stem rust pathogen. Stem rust is one of the most important diseases of wheat in the world. When single stem rust resistance (Sr) genes are deployed in wheat, they are often rapidly overcome by the pathogen. To this end, we initiated a search for novel sources of resistance in diverse wheat relatives and identified the wild goatgrass species Aegilops sharonesis (Sharon goatgrass) as a rich reservoir of resistance to wheat stem rust...
March 8, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28274958/cabozantinib-eradicates-advanced-murine-prostate-cancer-by-activating-anti-tumor-innate-immunity
#13
Akash Patnaik, Kenneth D Swanson, Eva Csizmadia, Aniruddh Solanki, Natalie Landon-Brace, Marina P Gehring, Katja Helenius, Brian M Olson, Athalia R Pyzer, Lily C Wang, Olivier Elemento, Jesse Novak, Thomas B Thornley, John M Asara, Laleh Montaser, Joshua J Timmons, Todd M Morgan, Yugang Wang, Elena Levantini, John G Clohessy, Kathleen Kelly, Pier Paolo Pandolfi, Jacalyn M Rosenblatt, David E Avigan, Huihui Ye, Jeffrey M Karp, Sabina Signoretti, Steven P Balk, Lewis C Cantley
Several kinase inhibitors that target aberrant signaling pathways in tumor cells have been deployed in cancer therapy. However, their impact on the tumor immune microenvironment remains poorly understood. The tyrosine kinase inhibitor cabozantinib showed striking responses in cancer clinical trial patients across several malignancies. Here we show that cabozantinib rapidly eradicates invasive, poorly-differentiated PTEN/p53 deficient murine prostate cancer. This was associated with enhanced release of neutrophil chemotactic factors from tumor cells, including CXCL12 and HMGB1, resulting in robust infiltration of neutrophils into the tumor...
March 8, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28272872/low-energy-co2-release-from-metal-organic-frameworks-triggered-by-external-stimuli
#14
Haiqing Li, Matthew R Hill
Groundbreaking research over the past 15 years has established metal-organic frameworks (MOFs) as adsorbents capable of unprecedented gas adsorption capacity. This has encouraged the contemplation of their use in applications such as increasing the storage capacity in natural gas fuel tanks, or the capture of carbon dioxide from coal-fired flue gas streams. However, while the gas adsorption capacity of MOFs is large, not all stored gas can be readily released to realize the efficient regeneration of MOF adsorbents...
March 8, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28260561/challenges-of-treating-adenovirus-infection-application-of-a-deployable-rapid-assembly-shelter-hospital
#15
Song Bai, Bao-Guo Yu, Yong-Zhong Zhang, Hui Ding, Zhou-Wei Wu, Bin Fan, Hao-Jun Fan, Shi-Ke Hou, Feng Chen
This article outlines the evolution of a rescue team in responding to adenovirus prevention with a deployable field hospital. The local governments mobilized a shelter hospital and a rescue team consisting of 59 members to assist with rescue and response efforts after an epidemic outbreak of adenovirus. We describe and evaluate the challenges of preparing for deployment, field hospital maintenance, treatment mode, and primary treatment methods. The field hospital established at the rescue scene consisted of a medical command vehicle, a computed tomography shelter, an X-ray shelter, a special laboratory shelter, an oxygen and electricity supply vehicle, and epidemic prevention and protection equipment...
March 6, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28258488/flexplex27-highly-multiplexed-rapid-dna-identification-for-law-enforcement-kinship-and-military-applications
#16
Ranjana Grover, Hua Jiang, Rosemary S Turingan, Julie L French, Eugene Tan, Richard F Selden
Rapid DNA identification is the use of a rugged, field-deployable system to generate short tandem repeat (STR) profiles in law enforcement, military, immigration, and homeland security applications. A performance verification study was conducted on the ANDE Rapid DNA identification system using FlexPlex27, a highly multiplexed, 27 locus assay that generates data for the expanded CODIS core loci and all additional STR loci required for international databasing. The assay contains 23 autosomal loci (D1S1656, D2S1338, D2S441, D3S1358, D5S81, D6S1043, D7S820, D8S1179, D10S1248, D12S391, D13S317, D16S539, D18S51, D19S433, D21S11, D22S1045, FGA, CSF1PO, Penta E, TH01, vWA, TPOX, and SE33), three Y-chromosomal loci (DYS391, DYS576, and DYS570), and Amelogenin...
March 3, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28244753/tuning-the-stability-and-the-reactivity-of-substituted-3-dendralenes-for-quick-access-to-diverse-copiously-functionalized-fused-polycycles-with-step-and-atom-economy
#17
Gonna Somu Naidu, Rekha Singh, Mukesh Kumar, Sunil K Ghosh
This is the first comprehensive study that details the synthesis of stable acyclic trisubstituted [3]dendralenes and deciphers their structural requisite for a successful diene transmissive Diels-Alder (DTDA) reaction by employing two different dienophiles and eventually generating a small repository of complex molecules, thus exemplifying how substituted [3]dendralenes could be deployed in diversity-oriented synthesis with high selectivities. A balance of reactivity and stability was struck by prudent selection of the position and nature of functional groups on these [3]dendralenes...
March 13, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28222727/developing-global-maps-of-insecticide-resistance-risk-to-improve-vector-control
#18
Michael Coleman, Janet Hemingway, Katherine Ann Gleave, Antoinette Wiebe, Peter W Gething, Catherine L Moyes
BACKGROUND: Significant reductions in malaria transmission have been achieved over the last 15 years with elimination occurring in a small number of countries, however, increasing drug and insecticide resistance threatens these gains. Insecticide resistance has decreased the observed mortality to the most commonly used insecticide class, the pyrethroids, and the number of alternative classes approved for use in public health is limited. Disease prevention and elimination relies on operational control of Anopheles malaria vectors, which requires the deployment of effective insecticides...
February 21, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28221970/genomic-tools-for-customized-recovery-and-detection-of-foodborne-shiga-toxigenic-escherichia-coli
#19
Michael Knowles, Sara Stinson, Dominic Lambert, Catherine Carrillo, Adam Koziol, Martine Gauthier, Burton Blais
Genomic antimicrobial resistance (AMR) prediction tools have the potential to support foodborne illness outbreak investigations through their application in the analysis of bacterial genomes from causative strains. The AMR marker profile of a strain of interest, initially identified in outbreak-associated clinical samples, may serve as the basis for customization of selective enrichment media, facilitating its recovery from samples in a food safety investigation. Different possibilities for AMR analyses include the use of comprehensive AMR gene databases such as the Comprehensive Antibiotic Resistance Database, which can be mined with in-house bioinformatics alignment tools (e...
December 2016: Journal of Food Protection
https://www.readbyqxmd.com/read/28219552/unusual-gastrointestinal-bleeding-after-sutureless-aortic-valve-replacement-a-word-of-caution
#20
Jules Iquille, Joseph Nader, Eric Colpart, Thierry Caus
We report the clinical case of a male patient who presented, after an aortic valve replacement with a rapid deployment bioprosthesis, a Heyde-like syndrome, secondary to a moderate aortic paravalvular leakage. All the digestive and hematologic investigations confirmed the diagnosis. A redo surgery to fill the paravalvular gap was accomplished and the postoperative course was uneventful, with a normalization of the biological parameters. To our knowledge, this is the first described case of such a complication with the new generation of sutureless bioprosthesis...
March 2017: Annals of Thoracic Surgery
keyword
keyword
113399
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"