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https://www.readbyqxmd.com/read/29344825/the-voltage-dependent-anion-channel-vdac-of-pacific-oysters-crassostrea-gigas-is-upaccumulated-during-infection-by-the-ostreid-herpesvirus-1-oshv-1-an-indicator-of-the-warburg-effect
#1
Lizenn Delisle, Marine Fuhrmann, Claudie Quéré, Marianna Pauletto, Vianney Pichereau, Fabrice Pernet, Charlotte Corporeau
Voltage-dependent anion channel (VDAC) is a key mitochondrial protein. VDAC drives cellular energy metabolism by controlling the influx and efflux of metabolites and ions through the mitochondrial membrane, playing a role in its permeabilization. This protein exerts a pivotal role during the white spot syndrome virus (WSSV) infection in shrimp, through its involvement in a particular metabolism that plays in favor of the virus, the Warburg effect. The Warburg effect corresponds to an atypical metabolic shift toward an aerobic glycolysis that provides energy for rapid cell division and resistance to apoptosis...
January 17, 2018: Marine Biotechnology
https://www.readbyqxmd.com/read/29342840/evaluation-of-rapid-early-warning-approaches-to-track-shellfish-toxins-associated-with-dinophysis-and-alexandrium-blooms
#2
Theresa K Hattenrath-Lehmann, Mark W Lusty, Ryan B Wallace, Bennie Haynes, Zhihong Wang, Maggie Broadwater, Jonathan R Deeds, Steve L Morton, William Hastback, Leonora Porter, Karen Chytalo, Christopher J Gobler
Marine biotoxin-contaminated seafood has caused thousands of poisonings worldwide this century. Given these threats, there is an increasing need for improved technologies that can be easily integrated into coastal monitoring programs. This study evaluates approaches for monitoring toxins associated with recurrent toxin-producing Alexandrium and Dinophysis blooms on Long Island, NY, USA, which cause paralytic and diarrhetic shellfish poisoning (PSP and DSP), respectively. Within contrasting locations, the dynamics of pelagic Alexandrium and Dinophysis cell densities, toxins in plankton, and toxins in deployed blue mussels (Mytilus edulis) were compared with passive solid-phase adsorption toxin tracking (SPATT) samplers filled with two types of resin, HP20 and XAD-2...
January 13, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29342158/real-time-community-detection-in-full-social-networks-on-a-laptop
#3
Benjamin Paul Chamberlain, Josh Levy-Kramer, Clive Humby, Marc Peter Deisenroth
For a broad range of research and practical applications it is important to understand the allegiances, communities and structure of key players in society. One promising direction towards extracting this information is to exploit the rich relational data in digital social networks (the social graph). As global social networks (e.g., Facebook and Twitter) are very large, most approaches make use of distributed computing systems for this purpose. Distributing graph processing requires solving many difficult engineering problems, which has lead some researchers to look at single-machine solutions that are faster and easier to maintain...
2018: PloS One
https://www.readbyqxmd.com/read/29338836/systems-levers-for-commissioning-primary-mental-healthcare-a-rapid-review
#4
Carla Meurk, Meredith Harris, Eryn Wright, Nicola Reavley, Roman Scheurer, Bridget Bassilios, Caroline Salom, Jane Pirkis
Primary Health Networks (PHNs) are a new institution for health systems management in the Australian healthcare system. PHNs will play a key role in mental health reform through planning and commissioning primary mental health services at a regional level, specifically adopting a stepped care approach. Selected PHNs are also trialling a healthcare homes approach. Little is known about the systems levers that could be applied by PHNs to achieve these aims. A rapid review of academic and grey literature published between 2006 and 2016 was undertaken to describe the use of systems levers in commissioning primary care services...
January 17, 2018: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/29334476/biological-control-of-botrytis-cinerea-interactions-with-native-vineyard-yeasts-from-washington-state
#5
Xuefei Wang, Dean A Glawe, Elizabeth K Kramer, David M Weller, Patricia Ann Okubara
Native yeasts are of increasing interest to researchers, grape growers, and vintners because of their potential for biocontrol activity, and their contributions to the aroma, flavor and mouthfeel qualities of wines. To assess biocontrol activity, we tested 11 yeasts from Washington vineyards, representing isolates of Candida saitoana, Curvibasidium pallidicorallinum, Metschnikowia chrysoperlae, Metschnikowia pulcherrima, Meyerozyma guilliermondii, Saccharomyces cerevisiae and Wickerhamomyces anomalus, for ability to colonize 'Thompson Seedless' grape berries, inhibit the growth of Botrytis cinerea in vitro, and suppress disease symptoms on isolated berries...
January 15, 2018: Phytopathology
https://www.readbyqxmd.com/read/29332263/creating-a-primary-care-workforce-strategies-for-leaders-clinicians-and-nurses
#6
Patricia Robinson, Julie Oyemaja, Bridget Beachy, Jeff Goodie, Lisa Sprague, Jennifer Bell, Mike Maples, Christy Ward
Many primary care clinics struggle with rapid implementation and systematic expansion of primary care behavioral health (PCBH) services. Often, an uneven course of program development is due to lack of attention to preparing clinic leadership, addressing operational factors, and training primary care providers (PCPs) and nurses. This article offers competency tools for clinic leaders, PCPs, and nurses to use in assessing their status and setting change targets. These tools were developed by researchers working to disseminate evidence-based interventions in primary care clinics that included fully integrated behavioral health consultants and were then used by early adaptors of the PCBH model...
January 13, 2018: Journal of Clinical Psychology in Medical Settings
https://www.readbyqxmd.com/read/29331055/the-challenges-and-possibilities-of-public-access-defibrillation
#7
REVIEW
Mattias Ringh, Jacob Hollenberg, Thea Palsgaard-Moeller, Leif Svensson, Mårten Rosenqvist, Freddy K Lippert, Mads Wissenberg, Carolina Malta Hansen, Andreas Claesson, Soren Viereck, Jolande A Zijlstra, Rudolph W Koster, Johan Herlitz, Marieke T Blom, Jo Kramer-Johansen, Hanno L Tan, Steffie Beesems, Michiel Hulleman, Theresa M Olasveengen, Fredrik Folke
Out-of-Hospital Cardiac Arrest (OHCA) is a major health problem that affects approximately four hundred thousand patients annually in the United States alone. It is a major challenge for the emergency medical system since decreased survival rates are directly proportional to the time delay from collapse to defibrillation. Historically, defibrillation has only been performed by physicians and in-hospital. With the development of automated external defibrillators (AEDs), rapid defibrillation by non-medical professionals and subsequently by trained or untrained lay bystanders has become possible...
January 13, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29330009/the-almanach-project-preliminary-results-and-potentiality-from-afghanistan
#8
A Bernasconi, F Crabbé, R Rossi, I Qani, A Vanobberghen, M Raab, S Du Mortier
INTRODUCTION: ALMANACH (ALgorithms for the MANagement of Acute CHildhood illnesses) is an electronic version of IMCI (Integrated Management of Childhood Illness) running on tablets. ALMANACH enhances its concept, it integrates well into health staff's daily consultation work and facilitates diagnosis and treatment. ALMANACH informs when to refer a child or to perform a rapid diagnostic test (RDT), recommends the right treatment dosage and synchronizes collected data real time with a Health Management Information System (DHIS2) for epidemiological evaluation and decision making...
December 28, 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29329961/-personalised-health-services-suggestions-for-their-effective-implementation
#9
Armin Töpfer, Georg Brabänder
A strategy of customisation, and its subsequent practical implementation as part of personalised treatment pathways, is an appropriate approach to increase benefits for patients and to strengthen the competitive position of the provider of health services. This requires restructuring and/or reorganising measures to enable variants within the treatment pathway as a value creation process to be adapted to each individual patient and his illness, living conditions and preferences. This 'mass customisation' approach allows us to achieve the objective of a constructive interconnection of customisation and standardisation of health services...
January 9, 2018: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/29311059/g-quadruplex-dna-motifs-in-the-malaria-parasite-plasmodium-falciparum-and-their-potential-as-novel-antimalarial-drug-targets
#10
Lynne M Harris, Katelyn R Monsell, Florian Noulin, M Toyin Famodimu, Nicolas Smargiasso, Christian Damblon, Paul Horrocks, Catherine J Merrick
G-quadruplexes are DNA or RNA secondary structures that can be formed from guanine-rich nucleic acids. These four-stranded structures, composed of stacked quartets of guanine bases, can be highly stable and have been demonstrated to occur in vivo in the DNA of human cells and other systems, where they play important biological roles, influencing processes such as telomere maintenance, DNA replication and transcription, or in the case of RNA G-quadruplexes, RNA translation and processing. We report for the first time that DNA G-quadruplexes can be detected in the nuclei of the malaria parasite Plasmodium falciparum, which has one of the most A/T-biased genomes sequenced and therefore possesses few guanine-rich sequences with the potential to form G-quadruplexes...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29300079/chemodosimeter-for-selective-and-sensitive-chromogenic-and-fluorogenic-detection-of-mustard-gas-for-real-time-analysis
#11
Vinod Kumar, Hemlata Rana, G Raviraju, Arvind K Gupta
Since the first use of chemical warfare agents (CWA) (1915) to the recent attacks in Syria (2017) on mankind, there have been many incidents where CWA have claimed thousands of lives and left many more contaminated. In order to provide the appropriate and immediate medical counter measure to the victims, the exact classification of these chemical agents within few minutes on the field itself using a rapid and simple detection technique is extremely important to save the lives of the effected people. This has motivated all of us to explore the novel strategies/detection systems that can be field deployable with better selectivity and greater sensitivity...
January 4, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29278831/using-drugs-in-un-safe-spaces-impact-of-perceived-illegality-on-an-underground-supervised-injecting-facility-in-the-united-states
#12
Peter J Davidson, Andrea M Lopez, Alex H Kral
BACKGROUND: Supervised injection facilities (SIFs) are spaces where people can consume pre-obtained drugs in hygienic circumstances with trained staff in attendance to provide emergency response in the event of an overdose or other medical emergency, and to provide counselling and referral to other social and health services. Over 100 facilities with formal legal sanction exist in ten countries, and extensive research has shown they reduce overdose deaths, increase drug treatment uptake, and reduce social nuisance...
December 23, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29278215/percutaneous-coronary-intervention-in-the-elderly-are-drug-coated-balloons-the-future
#13
Ioannis Merinopoulos, Tharusha Gunawardena, Upul Wickramarachchi, Alisdair Ryding, Simon Eccleshall, Vassilios S Vassiliou
Balloon angioplasty revolutionised percutaneous treatment for coronary artery disease four decades ago, but vessel-threatening dissections, elastic recoil and restenosis were major drawbacks to an otherwise successful long-lasting intervention. Subsequent advances with bare metal stents and then drug eluting stents followed, aiming to mitigate the risks of acute vessel closure and restenosis. However, stent implantation often necessitates dual antiplatelet therapy for a prolonged period of time, which in itself can lead to adverse outcomes, especially in the frail elderly population at higher risk of bleeding...
December 26, 2017: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29273761/new-seeding-approach-reduces-costs-and-time-to-outplant-sexually-propagated-corals-for-reef-restoration
#14
Valérie F Chamberland, Dirk Petersen, James R Guest, Udo Petersen, Mike Brittsan, Mark J A Vermeij
The use of sexually propagated corals is gaining popularity as an approach for reef restoration. However, manually attaching substrates with recently settled corals to the reef using binding materials is both time-consuming and expensive, limiting the use of this technique to small spatial scales. We present a novel approach whereby young corals are 'seeded' on the reef without the need for manual attachment to the benthos. We tested two tetrapod-shaped concrete substrates (7.9 and 9.8 cm in diameter) on which coral larvae were settled...
December 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29258444/evaluation-of-a-field-deployable-reverse-transcription-insulated-isothermal-pcr-for-rapid-and-sensitive-on-site-detection-of-zika-virus
#15
Mariano Carossino, Yanqiu Li, Pei-Yu A Lee, Chuan-Fu Tsai, Pin-Hsing Chou, Dennis Williams, Ashley Skillman, R Frank Cook, Grayson Brown, Hsiao-Fen G Chang, Hwa-Tang T Wang, Udeni B R Balasuriya
BACKGROUND: The recent emergence of Zika virus (ZIKV) in Brazil and its precipitous expansion throughout the Americas has highlighted the urgent need for a rapid and reliable on-site diagnostic assay suitable for viral detection. Such point-of-need (PON), low-cost diagnostics are essential for ZIKV control in vulnerable areas with limited resources. METHODS: We developed and evaluated a ZIKV-specific field-deployable RT-iiPCR reagent set targeting the E gene for rapid detection of ZIKV in ZIKV-spiked human and mosquito specimens, and compared its performance to the Center for Disease Control and Prevention (CDC) and Pan American Health Organization (PAHO) RT-qPCR assays targeting the E and NS2B genes, respectively...
December 19, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29250476/dynamic-network-model-for-smart-city-data-loss-resilience-case-study-city-to-city-network-for-crime-analytics
#16
Olivera Kotevska, A Gilad Kusne, Daniel V Samarov, Ahmed Lbath, Abdella Battou
Today's cities generate tremendous amounts of data, thanks to a boom in affordable smart devices and sensors. The resulting big data creates opportunities to develop diverse sets of context-aware services and systems, ensuring smart city services are optimized to the dynamic city environment. Critical resources in these smart cities will be more rapidly deployed to regions in need, and those regions predicted to have an imminent or prospective need. For example, crime data analytics may be used to optimize the distribution of police, medical, and emergency services...
2017: IEEE Access: Practical Innovations, Open Solutions
https://www.readbyqxmd.com/read/29247306/identifying-criteria-for-the-evaluation-of-the-implications-of-brain-reading-for-mental-privacy
#17
Giulio Mecacci, Pim Haselager
Contemporary brain reading technologies promise to provide the possibility to decode and interpret mental states and processes. Brain reading could have numerous societally relevant implications. In particular, the private character of mind might be affected, generating ethical and legal concerns. This paper aims at equipping ethicists and policy makers with conceptual tools to support an evaluation of the potential applicability and the implications of current and near future brain reading technology. We start with clarifying the concepts of mind reading and brain reading, and the different kinds of mental states that could in principle be read...
December 15, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/29242618/a-simple-platform-for-the-rapid-development-of-antimicrobials
#18
Stephen Albert Johnston, Valeriy Domenyuk, Nidhi Gupta, Milene Tavares Batista, John C Lainson, Zhan-Gong Zhao, Joel F Lusk, Andrey Loskutov, Zbigniew Cichacz, Phillip Stafford, Joseph Barten Legutki, Chris W Diehnelt
Recent infectious outbreaks highlight the need for platform technologies that can be quickly deployed to develop therapeutics needed to contain the outbreak. We present a simple concept for rapid development of new antimicrobials. The goal was to produce in as little as one week thousands of doses of an intervention for a new pathogen. We tested the feasibility of a system based on antimicrobial synbodies. The system involves creating an array of 100 peptides that have been selected for broad capability to bind and/or kill viruses and bacteria...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29238337/the-role-of-type-2-diabetes-for-the-development-of-pathogen-associated-cancers-in-the-face-of-the-hiv-aids-epidemic
#19
REVIEW
Melissa J Blumenthal, Sylvia Ujma, Arieh A Katz, Georgia Schäfer
The contribution of HIV to the development of pathogen-associated cancers has long been recognized, as has the contribution of type 2 diabetes for the development of several types of cancer. While HIV/AIDS-associated immunosuppression reduces immunosurveillance and indirectly contributes favorably to cancerogenesis, diabetes directly increases cancer development due to chronic low-grade inflammation, dysregulated glucose metabolism, hyperactivation of insulin-responsive pathways, and anti-apoptotic signaling...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29236014/identification-of-potential-sewer-mining-locations-a-monte-carlo-based-approach
#20
I K Tsoukalas, C K Makropoulos, S N Michas
Rapid urbanization affecting demand patterns, coupled with potential water shortages due to supply side impacts of climatic changes, has led to the emergence of new technologies for water and wastewater reuse. Sewer mining (SM) is a novel decentralized option that could potentially provide non-potable water for urban uses, including for example the irrigation of urban green spaces, providing a mid-scale solution to effective wastewater reuse. SM is based on extracting wastewater from local sewers and treatment at the point of demand and entails in some cases the return of treatment residuals back to the sewer system...
December 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
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