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https://www.readbyqxmd.com/read/29785201/speed-breeding-for-multiple-quantitative-traits-in-durum-wheat
#1
Samir Alahmad, Eric Dinglasan, Kung Ming Leung, Adnan Riaz, Nora Derbal, Kai P Voss-Fels, Jason A Able, Filippo M Bassi, Jack Christopher, Lee T Hickey
Background: Plant breeding requires numerous generations to be cycled and evaluated before an improved cultivar is released. This lengthy process is required to introduce and test multiple traits of interest. However, a technology for rapid generation advance named 'speed breeding' was successfully deployed in bread wheat ( Triticum aestivum L.) to achieve six generations per year while imposing phenotypic selection for foliar disease resistance and grain dormancy. Here, for the first time the deployment of this methodology is presented in durum wheat ( Triticum durum Desf...
2018: Plant Methods
https://www.readbyqxmd.com/read/29778056/one-century-sedimentary-record-of-heavy-metal-pollution-in-western-taihu-lake-china
#2
Yan Li, Shenglu Zhou, Qing Zhu, Baojie Li, Junxiao Wang, Chunhui Wang, Lian Chen, Shaohua Wu
Long-term trends of sediment compositions are important for assessing the impact of human activities on the sediment and protecting the sediment environment. In this study, based on the contents of heavy metals and the Pb isotope ratios in lake sediments, atmospheric dustfall and soil in Yixing, China, the representative heavy metals (Zn, Pb, Cr and Cd) in lake sediments from western Taihu Lake were studied. The evolution history of heavy metals in the local environment was constructed for the past 100 years...
May 16, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29774761/development-of-a-rapid-uplc-ms-ms-determination-of-urine-sulfocysteine-for-diagnosis-of-sulfocysteinuria-and-molybdenum-co-factor-deficiencies
#3
Yi Jiang, Brandon Mistretta, Sarah H Elsea, Qin Sun
AIM: Molybdenum co-factor deficiencies and isolated sulfite oxidase deficiency are rare autosomal recessively inherited diseases characterized by severe psychomotor impairment, intractable seizures, dislocated lens and dysmorphic facial features. The biochemical diagnosis of these diseases requires the determination of urine sulfocysteine. MATERIALS & METHODS: Urine sulfocysteine was quantified by an ultra-high performance liquid chromatography-MS/MS assay. The method was validated for linearity, accuracy, precision, recovery and stability...
May 18, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29773083/reprising-the-globalization-dimensions-of-international-health
#4
EDITORIAL
Ronald Labonté
Globalization is a fairly recent addition to the panoply of concepts describing the internationalization of health concerns. What distinguishes it from 'international health' or its newer morphing into 'global health' is a specific analytical concern with how globalization processes, past or present, but particularly since the start of our neoliberal era post-1980, is affecting health outcomes. Globalization processes influence health through multiple social pathways: from health systems and financing reforms to migration flows and internal displacement; via trade and investment treaties, labour market 'flexibilization', and the spread of unhealthy commodities; or through deploying human rights and environment protection treaties, and strengthening health diplomacy efforts, to create more equitable and sustainable global health outcomes...
May 18, 2018: Globalization and Health
https://www.readbyqxmd.com/read/29770249/snorkel-rapid-training-data-creation-with-weak-supervision
#5
Alexander Ratner, Stephen H Bach, Henry Ehrenberg, Jason Fries, Sen Wu, Christopher Ré
Labeling training data is increasingly the largest bottleneck in deploying machine learning systems. We present Snorkel, a first-of-its-kind system that enables users to train state-of- the-art models without hand labeling any training data. Instead, users write labeling functions that express arbitrary heuristics, which can have unknown accuracies and correlations. Snorkel denoises their outputs without access to ground truth by incorporating the first end-to-end implementation of our recently proposed machine learning paradigm, data programming...
November 2017: Proceedings of the VLDB Endowment
https://www.readbyqxmd.com/read/29769072/provider-and-patient-perceptions-of-malaria-rapid-diagnostic-test-use-in-nigeria-a-cross-sectional-evaluation
#6
Olugbenga A Mokuolu, Olufemi O Ajumobi, Godwin N Ntadom, Olanrewaju T Adedoyin, Alero A Roberts, Chimere O Agomo, Kate U Edozieh, Henrietta U Okafor, Robinson D Wammanda, Friday A Odey, Ibrahim K Maikore, Olatayo O Abikoye, Adekunle D Alabi, Chiomah Amajoh, Bala M Audu
BACKGROUND: Nigeria commenced a phased programmatic deployment of rapid diagnostic tests (RDT) at the primary health care (PHC) facility levels since 2011. Despite various efforts, the national testing rate for malaria is still very low. The uptake of RDT has been variable. This study was undertaken to determine the provider and patient perceptions to RDT use at the PHC level in Nigeria with their implications for improving uptake and compliance. METHODS: A cross-sectional survey was conducted in 120 randomly selected PHCs across six states, across the six-geopolitical zones of Nigeria in January 2013...
May 16, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29764393/telerehabilitation-versus-traditional-centre-based-pulmonary-rehabilitation-for-people-with-chronic-respiratory-disease-protocol-for-a-randomised-controlled-trial
#7
Narelle S Cox, Christine F McDonald, Jennifer A Alison, Ajay Mahal, Richard Wootton, Catherine J Hill, Janet Bondarenko, Heather Macdonald, Paul O'Halloran, Paolo Zanaboni, Ken Clarke, Deidre Rennick, Kaye Borgelt, Angela T Burge, Aroub Lahham, Bruna Wageck, Hayley Crute, Pawel Czupryn, Amanda Nichols, Anne E Holland
BACKGROUND: Pulmonary rehabilitation is an effective therapeutic intervention for people with chronic respiratory disease. However, fewer than 5% of eligible individuals receive pulmonary rehabilitation on an annual basis, largely due to limited availability of services and difficulties associated with travel and transport. The Rehabilitation Exercise At Home (REAcH) study is an assessor-blinded, multi-centre, randomised controlled equivalence trial designed to compare the efficacy of home-based telerehabilitation and traditional centre-based pulmonary rehabilitation in people with chronic respiratory disease...
May 15, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29760110/variability-in-summer-surface-residence-time-within-a-west-antarctic-peninsula-biological-hotspot
#8
Josh T Kohut, Peter Winsor, Hank Statscewich, Matthew J Oliver, Erick Fredj, Nicole Couto, Kim Bernard, William Fraser
Palmer Deep canyon along the central West Antarctic Peninsula is known to have higher phytoplankton biomass than the surrounding non-canyon regions, but the circulation mechanisms that transport and locally concentrate phytoplankton and Antarctic krill, potentially increasing prey availability to upper-trophic-level predators such as penguins and cetaceans, are currently unknown. We deployed a three-site high-frequency radar network that provided hourly surface circulation maps over the Palmer Deep hotspot...
June 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29756075/alterations-in-amino-acid-metabolism-during-growth-by-staphylococcus-aureus-following-exposure-to-h-2-o-2-a-multifactorial-approach
#9
Grace R Murphy, R Hugh Dunstan, Margaret M Macdonald, Johan Gottfries, Tim K Roberts
Temperature and pH are known to vary in a wound site due to the immune response and subsequent healing processes. This study used a multifactorial design to examine the cellular responses of Staphylococcus aureus to hydrogen peroxide (0-100 mM) when bacteria were grown in temperatures of 37 ± 2 °C and pH 7 ± 1, conditions potentially encountered in wound sites. A centroid sample was included in the design which represented the mid-point values of all three environmental parameters (37 °C, pH 7, 50 mM H2 O2 )...
May 2018: Heliyon
https://www.readbyqxmd.com/read/29754814/llamatags-a-versatile-tool-to-image-transcription-factor-dynamics-in-live-embryos
#10
Jacques P Bothma, Matthew R Norstad, Simon Alamos, Hernan G Garcia
Embryonic cell fates are defined by transcription factors that are rapidly deployed, yet attempts to visualize these factors in vivo often fail because of slow fluorescent protein maturation. Here, we pioneer a protein tag, LlamaTag, which circumvents this maturation limit by binding mature fluorescent proteins, making it possible to visualize transcription factor concentration dynamics in live embryos. Implementing this approach in the fruit fly Drosophila melanogaster, we discovered stochastic bursts in the concentration of transcription factors that are correlated with bursts in transcription...
April 26, 2018: Cell
https://www.readbyqxmd.com/read/29750967/evaluation-of-four-novel-isothermal-amplification-assays-towards-simple-and-rapid-genotyping-of-chloroquine-resistant-plasmodium-falciparum
#11
Madhvi Chahar, Anup Anvikar, Rajnikant Dixit, Neena Valecha
Loop mediated isothermal amplification (LAMP) assay is sensitive, prompt, high throughput and field deployable technique for nucleic acid amplification under isothermal conditions. In this study, we have developed and optimized four different visualization methods of loop-mediated isothermal amplification (LAMP) assay to detect Pfcrt K76T mutants of P. falciparum and compared their important features for one-pot in-field applications. Even though all the four tested LAMP methods could successfully detect K76T mutants of P...
May 8, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29747952/awake-thoracic-endovascular-aneurysm-repair-for-aortic-rupture-a-case-series
#12
Jessica Forcillo, Yazan M Duwayri, William D Jordan, Bradley G Leshnower
Thoracic endovascular aortic repair (TEVAR) has been proven to be the optimal therapy for patients with a ruptured descending thoracic aortic pathology. In these emergent settings, TEVAR provides a rapid delivery of treatment to an unstable patient with a lethal disease. Typically, the greatest challenge is maintaining hemodynamic stability until the time of graft deployment. In this report, we describe our technique of performing awake TEVAR for ruptured descending thoracic aortic disease.
April 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29735584/bioprosthetic-aortic-valve-durability-in-the-era-of-transcatheter-aortic-valve-implantation
#13
REVIEW
Erwan Salaun, Marie-Annick Clavel, Josep Rodés-Cabau, Philippe Pibarot
The main limitation of bioprosthetic valves is their limited durability, which exposes the patient to the risk of aortic valve reintervention. Transcatheter aortic valve implantation (TAVI) is considered a reasonable alternative to surgical aortic valve replacement (SAVR) in patients with intermediate or high surgical risk. TAVI is now rapidly expanding towards the lower risk populations. Although the results of midterm durability of the transcatheter bioprostheses are encouraging, their long-term durability remains largely unknown...
May 7, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29734579/assessment-of-air-passive-sampling-uptakes-for-volatile-organic-compounds-using-veram-devices
#14
Thalita Dallapícula Ramos, Miguel de la Guardia, Agustín Pastor, Francesc A Esteve-Turrillas
A calibration chamber has been designed and employed for the simple and easy determination of uptake sampling rate (RS ) of volatile organic compounds (VOCs) from air using passive samplers. A flow of clean air was continuously spiked, at a constant VOC concentration, by the microinjection of a standard solution by means of a T-type tube. The developed system allowed the complete evaporation at room temperature of the standard solution in acetone and the air concentration of VOCs was easily controlled by the regulation of the clean air flow, the standard solution concentration and its flow...
April 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29723168/malaria-surveillance-united-states-2015
#15
Kimberly E Mace, Paul M Arguin, Kathrine R Tan
PROBLEM/CONDITION: Malaria in humans is caused by intraerythrocytic protozoa of the genus Plasmodium. These parasites are transmitted by the bite of an infective female Anopheles species mosquito. The majority of malaria infections in the United States occur among persons who have traveled to regions with ongoing malaria transmission. However, malaria is occasionally acquired by persons who have not traveled out of the country through exposure to infected blood products, congenital transmission, laboratory exposure, or local mosquitoborne transmission...
May 4, 2018: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
https://www.readbyqxmd.com/read/29720926/the-study-of-atmospheric-ice-nucleating-particles-via-microfluidically-generated-droplets
#16
Mark D Tarn, Sebastien N F Sikora, Grace C E Porter, Daniel O'Sullivan, Mike Adams, Thomas F Whale, Alexander D Harrison, Jesús Vergara-Temprado, Theodore W Wilson, Jung-Uk Shim, Benjamin J Murray
Ice-nucleating particles (INPs) play a significant role in the climate and hydrological cycle by triggering ice formation in supercooled clouds, thereby causing precipitation and affecting cloud lifetimes and their radiative properties. However, despite their importance, INP often comprise only 1 in 103 -106 ambient particles, making it difficult to ascertain and predict their type, source, and concentration. The typical techniques for quantifying INP concentrations tend to be highly labour-intensive, suffer from poor time resolution, or are limited in sensitivity to low concentrations...
2018: Microfluidics and Nanofluidics
https://www.readbyqxmd.com/read/29718234/technical-points-for-aortic-valve-replacement-through-right-anterior-minithoracotomy
#17
Olivier Bouchot, Andranik Petrosyan, Marie Catherine Morgant, Ghislain Malapert
After 8 years of practice and over 400 operated patients, we present a technique of minimally invasive aortic valve replacement that can be used by all surgeons on many patients. The access to the aorta is via the 2nd or 3rd right anterior intercostal space. Cardiopulmonary bypass is provided using the femoral artery and vein. The aorta is clamped directly. One shot of Custodiol (EUSA Pharma, Limonest, France) is the most commonly used cardioplegia. Aortic valve replacement is performed in the regular way...
May 1, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29714118/prediction-of-response-to-targeted-and-immune-checkpoint-therapies
#18
Edward D Blair, Martina Kaufmann, Mieke Keppens
Targeted therapies continue to be key components of cancer treatment. New approaches to detection of acquired resistance at the genomic level, in combination with new therapies, help to overcome the challenges that are seen frequently, rapidly and broadly across tumor pathologies, and provide opportunities for cancer management. In the last several years, a new breed of modalities called immune checkpoint inhibitors have come to the forefront of clinically effective treatments. A plethora of rapid approvals and early access initiatives have seen anti-cytotoxic T-lymphocyte-associated antigen-4, and particularly anti-programmed death receptor-1 therapies, deployed in a number of tumor indications of high unmet need...
January 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29713503/mobile-health-messaging-service-and-helpdesk-for-south-african-mothers-momconnect-history-successes-and-challenges
#19
REVIEW
Peter Barron, Joanne Peter, Amnesty E LeFevre, Jane Sebidi, Marcha Bekker, Robert Allen, Annie Neo Parsons, Peter Benjamin, Yogan Pillay
MomConnect is a flagship programme of the South African National Department of Health that has reached over 1.5 million pregnant women. Using mobile technology, MomConnect provides pregnant and postpartum women with twice-weekly health information text messages as well as access to a helpdesk for patient queries and feedback. In just 3 years, MomConnect has been taken to scale to reach over 95% of public health facilities and has reached 63% of all pregnant women attending their first antenatal appointment...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29710839/building-in-briefcase-a-rapidly-deployable-environmental-sensor-suite-for-the-smart-building
#20
Kevin Weekly, Ming Jin, Han Zou, Christopher Hsu, Chris Soyza, Alexandre Bayen, Costas Spanos
A building’s environment has profound influence on occupant comfort and health. Continuous monitoring of building occupancy and environment is essential to fault detection, intelligent control, and building commissioning. Though many solutions for environmental measuring based on wireless sensor networks exist, they are not easily accessible to households and building owners who may lack time or technical expertise needed to set up a system and get quick and detailed overview of environmental conditions...
April 29, 2018: Sensors
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