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https://www.readbyqxmd.com/read/28934434/high-sensitivity-assays-for-plasmodium-falciparum-infection-by-immuno-polymerase-chain-reaction-detection-of-pfideh-and-pfldh-antigens
#1
Jianbing Mu, John F Andersen, Jesus G Valenzuela, Thomas E Wellems
Background: Rapid diagnostic tests based on Plasmodium falciparum histidine-rich protein II (PfHRP-II) and P. falciparum lactate dehydrogenase (PfLDH) antigens are widely deployed for detection of P. falciparum infection; however, these tests often miss cases of low-level parasitemia, and PfHRP-II tests can give false-negative results when P. falciparum strains do not express this antigen. Methods: We screened proteomic data for highly expressed P. falciparum proteins and compared their features to those of PfHRP-II and PfLDH biomarkers...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28933343/the-european-medical-corps-first-public-health-team-mission-and-future-perspectives
#2
Joana M Haussig, Ettore Severi, Jonathan Hj Baum, Veerle Vanlerberghe, Amparo Laiseca, Laurent Defrance, Cristina Brailescu, Denis Coulombier, Josep Jansa
The 2013-2016 Ebola epidemic in West Africa challenged traditional international mechanisms for public health team mobilisation to control outbreaks. Consequently, in February 2016, the European Union (EU) launched the European Medical Corps (EMC), a mechanism developed in collaboration with the World Health Organization (WHO) to rapidly deploy teams and equipment in response to public health emergencies inside and outside the EU. Public Health Teams (PHTs), a component of the EMC, consist of experts in communicable disease prevention and control from participating countries and the European Centre for Disease Prevention and Control (ECDC), to support affected countries and WHO in risk assessment and outbreak response...
September 14, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28931687/a-dna-vaccine-that-targets-hemagglutinin-to-antigen-presenting-cells-protects-mice-against-h7-influenza
#3
Tor Kristian Andersen, Fan Zhou, Rebecca Cox, Bjarne Bogen, Gunnveig Grødeland
Zoonotic influenza H7 viral infections have a case fatality rate of about 40%. Currently no or limited human to human spread has occurred, but we may be facing a severe pandemic threat if the virus acquires the ability to transmit between humans. Novel vaccines that can be rapidly produced for global distribution are urgently needed, and DNA vaccines may be the only type of vaccine that allows for the speed necessary to quench an emerging pandemic. Here, we have constructed DNA vaccines encoding the hemagglutinin (HA) from influenza A/chicken/Italy/13474/99 (H7N1)...
September 20, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28928433/measuring-the-role-of-seagrasses-in-regulating-sediment-surface-elevation
#4
Maria Potouroglou, James C Bull, Ken W Krauss, Hilary A Kennedy, Marco Fusi, Daniele Daffonchio, Mwita M Mangora, Michael N Githaiga, Karen Diele, Mark Huxham
Seagrass meadows provide numerous ecosystem services and their rapid global loss may reduce human welfare as well as ecological integrity. In common with the other 'blue carbon' habitats (mangroves and tidal marshes) seagrasses are thought to provide coastal defence and encourage sediment stabilisation and surface elevation. A sophisticated understanding of sediment elevation dynamics in mangroves and tidal marshes has been gained by monitoring a wide range of different sites, located in varying hydrogeomorphological conditions over long periods...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28919570/initial-clinical-experience-with-aview-a-clinical-computational-platform-for-intracranial-aneurysm-morphology-hemodynamics-and-treatment-management
#5
Jianping Xiang, Nicole Varble, Jason M Davies, Ansaar T Rai, Kenichi Kono, Shin-Ichiro Sugiyama, Mandy J Binning, Rabih G Tawk, Hoon Choi, Andrew J Ringer, Kenneth V Snyder, Elad I Levy, L Nelson Hopkins, Adnan H Siddiqui, Hui Meng
BACKGROUND: Intracranial aneurysm (IA) management is challenging. Clinicians often rely on varied and intuitively disparate ways of evaluating rupture risk that may only partially take into account complex hemodynamic and morphologic factors. We developed a prototype of a clinically-oriented, streamlined, computational platform, AView, for rapid assessment of hemodynamics and morphometrics in clinical settings. To show the potential clinical utility of AView, we report our initial multicenter experience highlighting the possible advantages of morphologic and hemodynamic analysis of IAs...
September 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28910465/combat-trousers-as-effective-improvised-pelvic-binders-a-comparative-cadaveric-study
#6
Andrew Loftus, Rhys Morris, Yasmin Friedmann, Ian Pallister, Paul Parker
BACKGROUND: Improvised explosive devices and landmines can cause pelvic fractures, which, in turn, can produce catastrophic hemorrhage. This cadaveric study compared the intrapelvic pressure changes that occurred with the application of an improvised pelvic binder adapted from the combat trousers worn by British military personnel with the commercially available trauma pelvic orthotic device (TPOD). METHODS: Six unembalmed cadavers (three male, three female) were used to simulate an unstable pelvic fracture with complete disruption of the posterior arch (AO/OTA 61-C1) by dividing the pelvic ring anteriorly and posteriorly...
2017: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28903795/rapid-triage-of-mental-health-risk-in-emergency-medical-workers-findings-from-typhoon-haiyan
#7
Lauren Sylwanowicz, Merritt Schreiber, Craig Anderson, Carlos Primero D Gundran, Emelie Santamaria, Jaifred Christian F Lopez
OBJECTIVE: To determine the ability of a novel responder mental health self-triage system to predict post-traumatic stress disorder (PTSD) in emergency medical responders after a disaster. METHODS: Participants in this study responded to Typhoon Haiyan, which struck the Philippines in November 2013. They completed the Psychological Simple Triage and Rapid Treatment (PsySTART) responder triage tool, the PTSD Checklist (PCL-5) and the Patient Health Questionnaire-8 (PHQ-8) shortly after responding to this disaster...
September 14, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28902466/learning-based-deformable-registration-for-infant-mri-by-integrating-random-forest-with-auto-context-model
#8
Lifang Wei, Xiaohuan Cao, Zhensong Wang, Yaozong Gao, Shunbo Hu, Li Wang, Guorong Wu, Dinggang Shen
PURPOSE: Accurately analyzing the rapid structural evolution of human brain in the first year of life is a key step in early brain development studies, which requires accurate deformable image registration. However, due to 1) dynamic appearance and 2) large anatomical changes, very few methods in the literature can work well for the registration of two infant brain MR images acquired at two arbitrary development phases, such as birth and one-year-old. METHODS: To address these challenging issues, we propose a learning-based registration method, which can handle the anatomical structures and the appearance changes between the two infant brain MR images with possible time gap...
September 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/28900432/assessing-and-exploiting-functional-diversity-in-germplasm-pools-to-enhance-abiotic-stress-adaptation-and-yield-in-cereals-and-food-legumes
#9
REVIEW
Sangam L Dwivedi, Armin Scheben, David Edwards, Charles Spillane, Rodomiro Ortiz
There is a need to accelerate crop improvement by introducing alleles conferring host plant resistance, abiotic stress adaptation, and high yield potential. Elite cultivars, landraces and wild relatives harbor useful genetic variation that needs to be more easily utilized in plant breeding. We review genome-wide approaches for assessing and identifying alleles associated with desirable agronomic traits in diverse germplasm pools of cereals and legumes. Major quantitative trait loci and single nucleotide polymorphisms (SNPs) associated with desirable agronomic traits have been deployed to enhance crop productivity and resilience...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28893603/human-polyclonal-antibodies-produced-in-transchromosomal-cattle-prevent-lethal-zika-virus-infection-and-testicular-atrophy-in-mice
#10
Derek R Stein, Joseph W Golden, Bryan D Griffin, Bryce M Warner, Charlene Ranadheera, Leanne Scharikow, Angela Sloan, Kathy L Frost, Darwyn Kobasa, Stephanie A Booth, Matthew Josleyn, John Ballantyne, Eddie Sullivan, Jin-An Jiao, Hua Wu, Zhongde Wang, Jay W Hooper, David Safronetz
Zika virus (ZIKV) is rapidly spreading throughout the Americas and is associated with significant fetal complications, most notably microcephaly. Treatment with polyclonal antibodies for pregnant women at risk of ZIKV-related complications could be a safe alternative to vaccination. We found that large quantities of human polyclonal antibodies could be rapidly produced in transchromosomal bovines (TcB) and successfully used to protect mice from lethal infection. Additionally, antibody treatment eliminated ZIKV induced tissue damage in immunologically privileged sites such as the brain and testes and protected against testicular atrophy...
September 8, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28892141/novel-insights-on-population-and-range-edge-dynamics-using-an-unparalleled-spatiotemporal-record-of-species-invasion
#11
Kristine Grayson, Derek M Johnson
Quantifying the complex spatial dynamics taking place at range edges is critical for understanding future distributions of species, yet very few systems have sufficient data or the spatial resolution to empirically test these dynamics. This paper reviews how data from a large-scale pest management program have provided important contributions to the fields of population dynamics and invasion biology. The invasion of gypsy moth (Lymantria dispar) is well-documented from its introduction near Boston, Massachusetts USA in 1869 to its current extent of over 900,000 km(2) in Eastern North America...
September 11, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28890066/ascending-aorta-endovascular-repair-of-a-symptomatic-penetrating-atherosclerotic-ulcer-with-a-custom-made-endo-graft
#12
Theodoros Kratimenos, Nikolaos G Baikoussis, Dimitrios Tomais, Michalis Argiriou
BACKGROUND: Thoracic endovascular aortic repair (TEVAR) has become lately the procedure of choice in the treatment of most pathologies of descending thoracic aorta. Aortic arch aneurysms also came to be treated by TEVAR with various hybrid techniques or custom made scalloped/fenestrated stent-grafts. Zone 0; ascending TEVAR is more challenging than TEVAR of the descending thoracic aorta or aortic arch because of the more complex pathology, hemodynamics, and anatomy. Ascending TEVAR can be a lifesaving treatment in selected high surgical risk patients...
September 7, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28888377/rapid-deployment-valves-finally-the-fog-is-lifting-benefits-beyond-crossclamp-and-bypass-times
#13
EDITORIAL
Günther Laufer, Dominik Wiedemann, Walter Randolph Chitwood
No abstract text is available yet for this article.
August 5, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28885934/medical-encounters-during-a-joint-canadian-u-s-exercise-in-the-high-arctic-exercise-arctic-ram
#14
Wendy Sullivan-Kwantes, Paul Dhillon, Len Goodman, Joseph J Knapik
The Arctic Ram Exercise was conducted in February 2016, near Resolute Bay on Cornwallis Island in Nunavut, Canada, to demonstrate the ability of the Canadian Armed Forces (CAF) to rapidly deploy to the arctic as an immediate response team. This report describes medical problems experienced by the 187 CAF and 28 U.S. forces involved in the exercise. Sixty-six airborne soldiers performed tactical static line jumps and linked up with soldiers on the ground for the exercise. Medical events were recorded by medics on the drop zone and by medical personnel at the Unit Medical Station in Resolute Bay...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28880252/bmrc-a-bitmap-based-maximum-range-counting-approach-for-temporal-data-in-sensor-monitoring-networks
#15
Bin Cao, Wangyuan Chen, Ying Shen, Chenyu Hou, Jung Yoon Kim, Lifeng Yu
Due to the rapid development of the Internet of Things (IoT), many feasible deployments of sensor monitoring networks have been made to capture the events in physical world, such as human diseases, weather disasters and traffic accidents, which generate large-scale temporal data. Generally, the certain time interval that results in the highest incidence of a severe event has significance for society. For example, there exists an interval that covers the maximum number of people who have the same unusual symptoms, and knowing this interval can help doctors to locate the reason behind this phenomenon...
September 7, 2017: Sensors
https://www.readbyqxmd.com/read/28876217/-we-are-disaster-response-experts-a-qualitative-study-on-the-mental-health-impact-of-volunteering-in-disaster-settings-among-combat-veterans
#16
Derrick Kranke, Eugenia L Weiss, Kevin C Heslin, Aram Dobalian
Volunteers serving in a disaster context may experience harmful mental health effects that could impede rescue operations. Exploratory research suggests that combat veterans who volunteer in Team Rubicon (TR)-a disaster relief social service organization with the mission of uniting the skills and experiences of military Veterans with first responders to rapidly deploy emergency response teams-have positive mental health responses when providing disaster relief. The objective of this qualitative study was to identify those nuances associated with combat veterans' mental health response in TR...
September 6, 2017: Social Work in Public Health
https://www.readbyqxmd.com/read/28875696/surface-enhanced-raman-spectroscopy-based-sandwich-immunoassays-for-multiplexed-detection-of-zika-and-dengue-viral-biomarkers
#17
Maria Sánchez-Purrà, Marc Carré-Camps, Helena de Puig, Irene Bosch, Lee Gehrke, Kimberly Hamad-Schifferli
Zika and dengue are mosquito-borne diseases that present similar nonspecific symptoms but possess dramatically different outcomes. The first line of defense in epidemic outbreaks are rapid point-of-care diagnostics. Because many outbreaks occur in areas that are resource poor, assays that are easy to use, inexpensive, and require no power have become invaluable in patient treatment, quarantining, and surveillance. Paper-based sandwich immunoassays such as lateral flow assays (LFAs) are attractive as point-of-care solutions as they have the potential for wider deployability than lab-based assays such as PCR...
September 6, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28870278/a-consultation-guide-for-assessing-the-applicability-of-health-technologies-a-case-study
#18
Stephanie Polus, Lisa Pfadenhauer, Louise Brereton, Wojciech Leppert, Philip Wahlster, Ansgar Gerhardus, Eva Rehfuess
OBJECTIVES: The translation of research findings into policy and practice is crucially dependent on the applicability of such findings in a given decision-making context. We explored in a case study whether a generic consultation guide to assess the applicability of a health technology could be rapidly deployed and deliver useful insights. METHODS: A consultation guide based on the context and implementation for complex interventions (CICI) framework was developed and piloted to assess the applicability of reinforced home-based palliative care in three European countries...
September 5, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28869967/a-solvent-and-vacuum-free-route-to-large-area-perovskite-films-for-efficient-solar-modules
#19
Han Chen, Fei Ye, Wentao Tang, Jinjin He, Maoshu Yin, Yanbo Wang, Fengxian Xie, Enbing Bi, Xudong Yang, Michael Grätzel, Liyuan Han
Recent advances in the use of organic-inorganic hybrid perovskites for optoelectronics have been rapid, with reported power conversion efficiencies of up to 22 per cent for perovskite solar cells. Improvements in stability have also enabled testing over a timescale of thousands of hours. However, large-scale deployment of such cells will also require the ability to produce large-area, uniformly high-quality perovskite films. A key challenge is to overcome the substantial reduction in power conversion efficiency when a small device is scaled up: a reduction from over 20 per cent to about 10 per cent is found when a common aperture area of about 0...
September 6, 2017: Nature
https://www.readbyqxmd.com/read/28868134/arkas-rapid-reproducible-rnaseq-analysis
#20
Anthony R Colombo, Timothy J Triche, Giridharan Ramsingh
The recently introduced Kallisto pseudoaligner has radically simplified the quantification of transcripts in RNA-sequencing experiments.  We offer cloud-scale RNAseq pipelines Arkas-Quantification, which deploys Kallisto for parallel cloud computations, and Arkas-Analysis, which annotates the Kallisto results by extracting structured information directly from source FASTA files with per-contig metadata and calculates the differential expression and gene-set enrichment analysis on both coding genes and transcripts...
2017: F1000Research
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