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Restifo, Nicolas

Joseph G Crompton, Madhusudhanan Sukumar, Rahul Roychoudhuri, David Clever, Alena Gros, Robert L Eil, Eric Tran, Ken-Ichi Hanada, Zhiya Yu, Douglas C Palmer, Sid P Kerkar, Ryan D Michalek, Trevor Upham, Anthony Leonardi, Nicolas Acquavella, Ena Wang, Francesco M Marincola, Luca Gattinoni, Pawel Muranski, Mark S Sundrud, Christopher A Klebanoff, Steven A Rosenberg, Douglas T Fearon, Nicholas P Restifo
Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) results in complete regression of advanced cancer in some patients, but the efficacy of this potentially curative therapy may be limited by poor persistence of TIL after adoptive transfer. Pharmacologic inhibition of the serine/threonine kinase Akt has recently been shown to promote immunologic memory in virus-specific murine models, but whether this approach enhances features of memory (e.g., long-term persistence) in TIL that are characteristically exhausted and senescent is not established...
January 15, 2015: Cancer Research
Nicolas Acquavella, David Clever, Zhiya Yu, Melody Roelke-Parker, Douglas C Palmer, Liqiang Xi, Holger Pflicke, Yun Ji, Alena Gros, Ken-Ichi Hanada, Ian S Goldlust, Gautam U Mehta, Christopher A Klebanoff, Joseph G Crompton, Madhusudhanan Sukumar, James J Morrow, Zulmarie Franco, Luca Gattinoni, Hui Liu, Ena Wang, Francesco Marincola, David F Stroncek, Chyi-Chia R Lee, Mark Raffeld, Marcus W Bosenberg, Rahul Roychoudhuri, Nicholas P Restifo
Both targeted inhibition of oncogenic driver mutations and immune-based therapies show efficacy in treatment of patients with metastatic cancer, but responses can be either short lived or incompletely effective. Oncogene inhibition can augment the efficacy of immune-based therapy, but mechanisms by which these two interventions might cooperate are incompletely resolved. Using a novel transplantable BRAF(V600E)-mutant murine melanoma model (SB-3123), we explored potential mechanisms of synergy between the selective BRAF(V600E) inhibitor vemurafenib and adoptive cell transfer (ACT)-based immunotherapy...
January 2015: Cancer Immunology Research
Paolo Locatelli, Vittorio Montefusco, Elena Sini, Nicola Restifo, Roberta Facchini, Michele Torresani
The volume and the complexity of clinical and administrative information make Information and Communication Technologies (ICTs) essential for running and innovating healthcare. This paper tells about a project aimed to design, develop and implement a set of organizational models, acknowledged procedures and ICT tools (Mobile & Wireless solutions and Automatic Identification and Data Capture technologies) to improve actual support, safety, reliability and traceability of a specific therapy management (stem cells)...
2013: Studies in Health Technology and Informatics
Sid P Kerkar, Anthony J Leonardi, Nicolas van Panhuys, Ling Zhang, Zhiya Yu, Joseph G Crompton, Jenny H Pan, Douglas C Palmer, Richard A Morgan, Steven A Rosenberg, Nicholas P Restifo
Engineering CD8⁺ T cells to deliver interleukin 12 (IL-12) to the tumor site can lead to striking improvements in the ability of adoptively transferred T cells to induce the regression of established murine cancers. We have recently shown that IL-12 triggers an acute inflammatory environment that reverses dysfunctional antigen presentation by myeloid-derived cells within tumors and leads to an increase in the infiltration of adoptively transferred antigen-specific CD8⁺ T cells. Here, we find that local delivery of IL-12 increased the expression of Fas within tumor-infiltrating macrophages, dendritic cells, and myeloid-derived suppressor cells (MDSC), and that these changes were abrogated in mice deficient in IL-12-receptor signaling...
July 2013: Molecular Therapy: the Journal of the American Society of Gene Therapy
Zeev Waks, Esther Goldbraich, Ariel Farkash, Michele Torresani, Rossella Bertulli, Nicola Restifo, Paolo Locatelli, Paolo Casali, Boaz Carmeli
Clinical decision support systems (CDSSs) are gaining popularity as tools that assist physicians in optimizing medical care. These systems typically comply with evidence-based medicine and are designed with input from domain experts. Nonetheless, deviations from CDSS recommendations are abundant across a broad spectrum of disorders, raising the question as to why this phenomenon exists. Here, we analyze this gap in adherence to a clinical guidelines-based CDSS by examining the physician treatment decisions for 1329 adult soft tissue sarcoma patients in northern Italy using patient-specific parameters...
2013: Studies in Health Technology and Informatics
Boaz Carmeli, Paolo Casali, Anna Goldbraich, Abigail Goldsteen, Carmel Kent, Lisa Licitra, Paolo Locatelli, Nicola Restifo, Ruty Rinott, Elena Sini, Michele Torresani, Zeev Waks
The personalized medicine era stresses a growing need to combine evidence-based medicine with case based reasoning in order to improve the care process. To address this need we suggest a framework to generate multi-tiered statistical structures we call Evicases. Evicase integrates established medical evidence together with patient cases from the bedside. It then uses machine learning algorithms to produce statistical results and aggregators, weighted predictions, and appropriate recommendations. Designed as a stand-alone structure, Evicase can be used for a range of decision support applications including guideline adherence monitoring and personalized prognostic predictions...
2012: Studies in Health Technology and Informatics
Paolo Locatelli, Emanuele Baj, Nicola Restifo, Gianni Origgi, Silvia Bragagia
Open source is a still unexploited chance for healthcare organizations and technology providers to answer to a growing demand for innovation and to join economical benefits with a new way of managing hospital information systems. This chapter will present the case of the web enterprise clinical portal developed in Italy by Niguarda Hospital in Milan with the support of Fondazione Politecnico di Milano, to enable a paperless environment for clinical and administrative activities in the ward. This represents also one rare case of open source technology and reuse in the healthcare sector, as the system's porting is now taking place at Besta Neurological Institute in Milan...
2011: Advances in Experimental Medicine and Biology
Christopher A Klebanoff, Nicolas Acquavella, Zhiya Yu, Nicholas P Restifo
Enthusiasm for therapeutic cancer vaccines has been rejuvenated with the recent completion of several large, randomized phase III clinical trials that in some cases have reported an improvement in progression free or overall survival. However, an honest appraisal of their efficacy reveals modest clinical benefit and a frequent requirement for patients with relatively indolent cancers and minimal or no measurable disease. Experience with adoptive cell transfer-based immunotherapies unequivocally establishes that T cells can mediate durable complete responses, even in the setting of advanced metastatic disease...
January 2011: Immunological Reviews
Paolo Locatelli, Nicola Restifo, Luca Gastaldi, Elena Sini, Michele Torresani
Health care organizations can gain great value from Information and Communication Technologies (ICT), yet, although there is growing awareness of the potential benefits associated with their use, results often fall far short of expectations. Each year, the "ICT in Health Care" Observatory--part of the Politecnico di Milano School of Management--outlines a profile of the role of ICT in the Italian health care industry, investigating current projects in terms of their impact on processes and organizations, implementation state of the art, governance models, and prospective pathways...
2010: Studies in Health Technology and Informatics
Giovanna Bollini, Angela Lolli, Raffaele Zaza, Gianni Origgi, Silvia Bragagia, Paolo Locatelli, Nicola Restifo
The rapid evolution of healthcare and the need to contain costs, to decrease the time of patients' hospitalization, and to improve the quality of care has led the nursing profession to face new challenges. This paper describes the case study of A.O. Ospedale Niguarda in Milan (Italy), a public healthcare provider where the key role of Nursing is being recognized according to international common practice. Also considering the context of Italian healthcare, attention will be drawn to concrete actions carried out on the organizational side and also for what concerns IT tools supporting nursing activities...
2009: Studies in Health Technology and Informatics
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