Lixia Xu, Ying Zhang, Zhilong Lin, Xinlang Deng, Xiaoxue Ren, Mingle Huang, Shangru Li, Qianying Zhou, Fei Fang, Qingxia Yang, Gaomin Zheng, Zebin Chen, Zhongdao Wu, Xi Sun, Jie Lin, Jingxian Shen, Jianping Guo, Xiaoxing Li, Tianchen Xue, Jing Tan, Xiaoxuan Lin, Li Tan, Hong Peng, Shunli Shen, Sui Peng, Shaoqiang Li, Lijian Liang, James M Cleary, Jiaming Lai, Yubin Xie, Ming Kuang
BACKGROUND & AIMS: Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer with high lethality. Clonorchis sinensis (C. sinensis) infection is an important risk factor for ICC. Here we investigated the clinical impact and underlying molecular characteristics of C. sinensis-infected ICC. METHODS: We performed single-cell RNA sequencing, whole exome sequencing, RNA-sequencing, metabolomics and spatial transcriptomics in 251 ICC patients from three medical centers...
March 18, 2024: Journal of Hepatology