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Sean Zheng

Xiaojun Wang, Chang Gu, Hongzhi Zheng, Yu-Mo Zhang, Sean Xiao-An Zhang
A multi-state and multi-stimuli-responsive oxazine molecular switch combining electro-base property and sensitively base/acid responsive properties was designed and synthesized. The multi-state structures of the molecular switch with different colors were speculated by comparison the optical properties with reference molecules and confirmed by NMR. The color switching mechanism under the stimulation of acid and base was investigated by DFT calculation. Three single states can be obtained and the switching is unidirectional under the stimulation of acid and base...
March 15, 2018: Chemistry, An Asian Journal
Na Zhao, Jin Cao, Longyong Xu, Qianzi Tang, Lacey E Dobrolecki, Xiangdong Lv, Manisha Talukdar, Yang Lu, Xiaoran Wang, Dorothy Z Hu, Qing Shi, Yu Xiang, Yunfei Wang, Xia Liu, Wen Bu, Yi Jiang, Mingzhou Li, Yingyun Gong, Zheng Sun, Haoqiang Ying, Bo Yuan, Xia Lin, Xin-Hua Feng, Sean M Hartig, Feng Li, Haifa Shen, Yiwen Chen, Leng Han, Qingping Zeng, John B Patterson, Benny Abraham Kaipparettu, Nagireddy Putluri, Frank Sicheri, Jeffrey M Rosen, Michael T Lewis, Xi Chen
The unfolded protein response (UPR) is a cellular homeostatic mechanism that is activated in many human cancers and plays pivotal roles in tumor progression and therapy resistance. However, the molecular mechanisms for UPR activation and regulation in cancer cells remain elusive. Here, we show that oncogenic MYC regulates the inositol-requiring enzyme 1 (IRE1)/X-box binding protein 1 (XBP1) branch of the UPR in breast cancer via multiple mechanisms. We found that MYC directly controls IRE1 transcription by binding to its promoter and enhancer...
February 26, 2018: Journal of Clinical Investigation
Michael O'Donnell, Leif D Nelson, Evi Ackermann, Balazs Aczel, Athfah Akhtar, Silvio Aldrovandi, Nasseem Alshaif, Ronald Andringa, Mark Aveyard, Peter Babincak, Nursena Balatekin, Scott A Baldwin, Gabriel Banik, Ernest Baskin, Raoul Bell, Olga Białobrzeska, Angie R Birt, Walter R Boot, Scott R Braithwaite, Jessie C Briggs, Axel Buchner, Desiree Budd, Kathryn Budzik, Lottie Bullens, Richard L Bulley, Peter R Cannon, Katarzyna Cantarero, Joseph Cesario, Stephanie Chambers, Christopher R Chartier, Peggy Chekroun, Clara Chong, Axel Cleeremans, Sean P Coary, Jacob Coulthard, Florien M Cramwinckel, Thomas F Denson, Marcos Díaz-Lago, Theresa E DiDonato, Aaron Drummond, Julia Eberlen, Titus Ebersbach, John E Edlund, Katherine M Finnigan, Justin Fisher, Natalia Frankowska, Efraín García-Sánchez, Frank D Golom, Andrew J Graves, Kevin Greenberg, Mando Hanioti, Heather A Hansen, Jenna A Harder, Erin R Harrell, Andree Hartanto, Michael Inzlicht, David J Johnson, Andrew Karpinski, Victor N Keller, Olivier Klein, Lina Koppel, Emiel Krahmer, Anthony Lantian, Michael J Larson, Jean-Baptiste Légal, Richard E Lucas, Dermot Lynott, Corey M Magaldino, Karlijn Massar, Matthew T McBee, Neil McLatchie, Nadhilla Melia, Michael C Mensink, Laura Mieth, Samantha Moore-Berg, Geraldine Neeser, Ben R Newell, Marret K Noordewier, Asil Ali Özdogğru, Myrto Pantazi, Michał Parzuchowski, Kim Peters, Michael C Philipp, Monique M H Pollmann, Panagiotis Rentzelas, Rosa Rodríguez-Bailón, Jan Philipp Röer, Ivan Ropovik, Nelson A Roque, Carolina Rueda, Bastiaan T Rutjens, Katey Sackett, Janos Salamon, Ángel Sánchez-Rodríguez, Blair Saunders, Juliette Schaafsma, Michael Schulte-Mecklenbeck, David R Shanks, Martin F Sherman, Kenneth M Steele, Niklas K Steffens, Jessie Sun, Kyle J Susa, Barnabas Szaszi, Aba Szollosi, Ricardo M Tamayo, Gustav Tinghög, Yuk-Yue Tong, Carol Tweten, Miguel A Vadillo, Deisy Valcarcel, Nicolas Van der Linden, Michiel van Elk, Frenk van Harreveld, Daniel Västfjäll, Simine Vazire, Philippe Verduyn, Matt N Williams, Guillermo B Willis, Sarah E Wood, Chunliang Yang, Oulmann Zerhouni, Robert Zheng, Mark Zrubka
Dijksterhuis and van Knippenberg (1998) reported that participants primed with a category associated with intelligence ("professor") subsequently performed 13% better on a trivia test than participants primed with a category associated with a lack of intelligence ("soccer hooligans"). In two unpublished replications of this study designed to verify the appropriate testing procedures, Dijksterhuis, van Knippenberg, and Holland observed a smaller difference between conditions (2%-3%) as well as a gender difference: Men showed the effect (9...
February 1, 2018: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
Li Zheng, Sean D Conner
Notch signaling is an evolutionarily conserved pathway that is essential for development, where it controls processes ranging from cell differentiation to survival. Transport through endosomes is a critical step in regulating Notch signaling capacity, where the E3 ubiquitin ligase DTX1 is thought to control Notch1 intracellular transport decisions by direct receptor ubiquitination. However, how DTX1 regulates Notch1 transport within endosomes and the consequence of Notch1 ubiquitination by DTX1 remain unresolved...
February 12, 2018: Proceedings of the National Academy of Sciences of the United States of America
Hongzhi Zheng, Wanru Li, Wen Li, Xiaojun Wang, Zhiyong Tang, Sean Xiao-An Zhang, Yan Xu
Circularly polarized light (CPL) is central to photonic technologies. A key challenge lies in developing a general route for generation of CPL with tailored chiroptical activity using low-cost raw materials suitable for scale-up. This study presents that cellulose films with photonic bandgaps (PBG) and left-handed helical sense have an intrinsic ability for circular polarization leading to PBG-based CPL with extraordinary |g | values, well-defiend handedness, and tailorable wavelength by the PBG change. Using such cellulose films, incident light ranging from near-UV to near-IR can be transformed to passive L-CPL and R-CPL with viewing-side-dependent handedness and |g | values up to 0...
February 12, 2018: Advanced Materials
Alison P Klein, Brian M Wolpin, Harvey A Risch, Rachael Z Stolzenberg-Solomon, Evelina Mocci, Mingfeng Zhang, Federico Canzian, Erica J Childs, Jason W Hoskins, Ashley Jermusyk, Jun Zhong, Fei Chen, Demetrius Albanes, Gabriella Andreotti, Alan A Arslan, Ana Babic, William R Bamlet, Laura Beane-Freeman, Sonja I Berndt, Amanda Blackford, Michael Borges, Ayelet Borgida, Paige M Bracci, Lauren Brais, Paul Brennan, Hermann Brenner, Bas Bueno-de-Mesquita, Julie Buring, Daniele Campa, Gabriele Capurso, Giulia Martina Cavestro, Kari G Chaffee, Charles C Chung, Sean Cleary, Michelle Cotterchio, Frederike Dijk, Eric J Duell, Lenka Foretova, Charles Fuchs, Niccola Funel, Steven Gallinger, J Michael M Gaziano, Maria Gazouli, Graham G Giles, Edward Giovannucci, Michael Goggins, Gary E Goodman, Phyllis J Goodman, Thilo Hackert, Christopher Haiman, Patricia Hartge, Manal Hasan, Peter Hegyi, Kathy J Helzlsouer, Joseph Herman, Ivana Holcatova, Elizabeth A Holly, Robert Hoover, Rayjean J Hung, Eric J Jacobs, Krzysztof Jamroziak, Vladimir Janout, Rudolf Kaaks, Kay-Tee Khaw, Eric A Klein, Manolis Kogevinas, Charles Kooperberg, Matthew H Kulke, Juozas Kupcinskas, Robert J Kurtz, Daniel Laheru, Stefano Landi, Rita T Lawlor, I-Min Lee, Loic LeMarchand, Lingeng Lu, Núria Malats, Andrea Mambrini, Satu Mannisto, Roger L Milne, Beatrice Mohelníková-Duchoňová, Rachel E Neale, John P Neoptolemos, Ann L Oberg, Sara H Olson, Irene Orlow, Claudio Pasquali, Alpa V Patel, Ulrike Peters, Raffaele Pezzilli, Miquel Porta, Francisco X Real, Nathaniel Rothman, Ghislaine Scelo, Howard D Sesso, Gianluca Severi, Xiao-Ou Shu, Debra Silverman, Jill P Smith, Pavel Soucek, Malin Sund, Renata Talar-Wojnarowska, Francesca Tavano, Mark D Thornquist, Geoffrey S Tobias, Stephen K Van Den Eeden, Yogesh Vashist, Kala Visvanathan, Pavel Vodicka, Jean Wactawski-Wende, Zhaoming Wang, Nicolas Wentzensen, Emily White, Herbert Yu, Kai Yu, Anne Zeleniuch-Jacquotte, Wei Zheng, Peter Kraft, Donghui Li, Stephen Chanock, Ofure Obazee, Gloria M Petersen, Laufey T Amundadottir
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10-8). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36...
February 8, 2018: Nature Communications
Xiangkun Yang, Sean X Naughton, Zhen Han, Maomao He, Y George Zheng, Alvin V Terry, Michael G Bartlett
Acetylation of α-tubulin at Lys-40 is a potential biomarker for cognitive deficits in various neurological disorders. However, this key PTM has not been previously studied with mass spectrometry, due to the inadequate distribution of tryptic cleavage sites. Following peptic digestion, a surrogate sequence containing this key PTM site was identified, and was found to be stable and quantitatively reproducible. A highly sensitive and specific SISCAPA-LC-MS method for quantitating rat brain tubulin acetylation was developed, validated and applied, and only required a small amount of tissue (2...
January 10, 2018: Analytical Chemistry
Li Zheng, Sean D Conner
The Notch signaling pathway is essential throughout development and continues into adulthood where it performs a critical role in tissue homeostasis. The fact that defects in signaling can lead to malignancy illustrate the need to tightly control Notch activity. GSK3β is an established regulator of the Notch signaling pathway, although its mechanism of action remains unclear. Given the emerging role for GSK3β in receptor trafficking, we tested the idea that GSK3β controls signaling by regulating Notch transport...
December 13, 2017: Molecular Biology of the Cell
Yuxi Zheng, Sean P Donahue
Bilateral superior rectus transposition with bilateral medial rectus recession has been described successfully for treatment of Duane's syndrome but never for Möbius syndrome. The authors describe a child with Möbius syndrome who presented with large bilateral abduction deficits and esotropia. This surgical treatment resulted in marked improvement of said deficits. [J Pediatr Ophthalmol Strabismus. 2017;54:e81-e82.].
November 17, 2017: Journal of Pediatric Ophthalmology and Strabismus
John F O'Sullivan, Jordan E Morningstar, Qiong Yang, Baohui Zheng, Yan Gao, Sarah Jeanfavre, Justin Scott, Celine Fernandez, Hui Zheng, Sean O'Connor, Paul Cohen, Ramachandran S Vasan, Michelle T Long, James G Wilson, Olle Melander, Thomas J Wang, Caroline Fox, Randall T Peterson, Clary B Clish, Kathleen E Corey, Robert E Gerszten
Unbiased, "nontargeted" metabolite profiling techniques hold considerable promise for biomarker and pathway discovery, in spite of the lack of successful applications to human disease. By integrating nontargeted metabolomics, genetics, and detailed human phenotyping, we identified dimethylguanidino valeric acid (DMGV) as an independent biomarker of CT-defined nonalcoholic fatty liver disease (NAFLD) in the offspring cohort of the Framingham Heart Study (FHS) participants. We verified the relationship between DMGV and early hepatic pathology...
October 30, 2017: Journal of Clinical Investigation
Hugh Morris, Mark A F Gillingham, Lenka Plavcová, Sean M Gleason, Mark E Olson, David A Coomes, Esther Fichtler, Matthias M Klepsch, Hugo I Martínez-Cabrera, Daniel J McGlinn, Elisabeth A Wheeler, Jingming Zheng, Kasia Ziemińska, Steven Jansen
Parenchyma represents a critically important living tissue in the sapwood of the secondary xylem of woody angiosperms. Considering various interactions between parenchyma and water transporting vessels, we hypothesise a structure-function relationship between both cell types. Through a generalised additive mixed model approach based on 2,332 woody angiosperm species derived from the literature, we explored the relationship between the proportion and spatial distribution of ray and axial parenchyma and vessel size, while controlling for maximum plant height and a range of climatic factors...
October 19, 2017: Plant, Cell & Environment
Xiaojun Wang, Wen Li, Wanru Li, Chang Gu, Hongzhi Zheng, Yuyang Wang, Yu-Mo Zhang, Minjie Li, Sean Xiao-An Zhang
RGB color-tunable "turn-on" electrofluorochromic (EFC) devices with high color purity (457 nm for blue, 539 nm for green, and 641 nm for red), relatively quick response/fading speeds and remarkable fluorescence contrast ratios are successfully fabricated. They exhibit great potential for increasingly important multistage encrypted information storage and displays.
September 28, 2017: Chemical Communications: Chem Comm
Chee Meng Lee, Huili Zheng, Veronique Kiak-Mien Tan, Tira Jing-Ying Tan, Ravindran Kanesvaran, Fuh-Yong Wong, Yi Rong Sim, Wei Sean Yong, Preetha Madhukumar, Kong Wee Ong, Benita Kiat-Tee Tan
AIM: The optimal treatment of breast cancer for extremely elderly patients (aged ≥ 80 years) is debatable. With an aging population, management of this group of patients will be increasingly common. This study aims to compare the survival outcomes of extremely elderly patients against younger ones, following different treatment modalities within each stage. The differences in treatment patterns across different stages have also been examined. METHODS: Female Singapore Citizens and Permanent Residents diagnosed with breast cancer from 2003 to 2014 were identified from the Singapore Cancer Registry...
December 2017: Breast: Official Journal of the European Society of Mastology
Matt Aldag, Regina C Armstrong, Faris Bandak, Patrick S F Bellgowan, Timothy Bentley, Sean Biggerstaff, Katrina Caravelli, Joan Cmarik, Alicia Crowder, Thomas J DeGraba, Travis A Dittmer, Richard G Ellenbogen, Colin Greene, Raj K Gupta, Ramona Hicks, Stuart Hoffman, Robert C Latta, Michael J Leggieri, Donald Marion, Robert Mazzoli, Michael McCrea, John O'Donnell, Mark Packer, James B Petro, Todd E Rasmussen, Wendy Sammons-Jackson, Richard Shoge, Victoria Tepe, Ladd A Tremaine, James Zheng
The United States Department of Defense Blast Injury Research Program Coordinating Office organized the 2015 International State-of-the-Science meeting to explore links between blast-related head injury and the development of chronic traumatic encephalopathy (CTE). Before the meeting, the planning committee examined articles published between 2005 and October 2015 and prepared this literature review, which summarized broadly CTE research and addressed questions about the pathophysiological basis of CTE and its relationship to blast- and nonblast-related head injury...
September 2017: Journal of Neurotrauma
Leon Zheng, Caleb J Kelly, Kayla D Battista, Rachel Schaefer, Jordi M Lanis, Erica E Alexeev, Ruth X Wang, Joseph C Onyiah, Douglas J Kominsky, Sean P Colgan
Commensal interactions between the enteric microbiota and distal intestine play important roles in regulating human health. Short-chain fatty acids (SCFAs), such as butyrate, produced through anaerobic microbial metabolism represent a major energy source for the host colonic epithelium and enhance epithelial barrier function through unclear mechanisms. Separate studies revealed that the epithelial anti-inflammatory IL-10 receptor α subunit (IL-10RA) is also important for barrier formation. Based on these findings, we examined if SCFAs promote epithelial barrier through IL-10RA-dependent mechanisms...
October 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
Cheng-Guo Wu, Hui Chen, Feng Guo, Vikash K Yadav, Sean J Mcilwain, Michael Rowse, Alka Choudhary, Ziqing Lin, Yitong Li, Tingjia Gu, Aiping Zheng, Qingge Xu, Woojong Lee, Eduard Resch, Benjamin Johnson, Jenny Day, Ying Ge, Irene M Ong, Mark E Burkard, Ylva Ivarsson, Yongna Xing
Protein phosphatase 2A (PP2A) is a major Ser/Thr phosphatase; it forms diverse heterotrimeric holoenzymes that counteract kinase actions. Using a peptidome that tiles the disordered regions of the human proteome, we identified proteins containing [LMFI]xx[ILV]xEx motifs that serve as interaction sites for B'-family PP2A regulatory subunits and holoenzymes. The B'-binding motifs have important roles in substrate recognition and in competitive inhibition of substrate binding. With more than 100 novel ligands identified, we confirmed that the recently identified LxxIxEx B'α-binding motifs serve as common binding sites for B' subunits with minor variations, and that S/T phosphorylation or D/E residues at positions 2, 7, 8 and 9 of the motifs reinforce interactions...
2017: Cell Discovery
Sean L Zheng, Alistair J Roddick, Salma Ayis
BACKGROUND: Aliskiren was shown to increase adverse events in patients with diabetes and concomitant renin-angiotensin blockade. We aim to investigate the efficacy and safety of aliskiren in patients with diabetes and increased cardiovascular risk or established cardiovascular disease. METHODS: MEDLINE and Embase were searched for prospective studies comparing addition of aliskiren to standard medical therapy in patients with diabetes and cardiovascular disease, or ⩾1 additional cardiovascular risk factor (hypertension, abnormal lipid profile, microalbuminuria/proteinuria, chronic kidney disease)...
September 2017: Diabetes & Vascular Disease Research
Sean Lee Zheng, Fiona T Chan, Adam A Nabeebaccus, Ajay M Shah, Theresa McDonagh, Darlington O Okonko, Salma Ayis
BACKGROUND: Clinical drug trials in patients with heart failure and preserved ejection fraction have failed to demonstrate improvements in mortality. METHODS: We systematically searched Medline, Embase and the Cochrane Central Register of Controlled Trials for randomised controlled trials (RCT) assessing pharmacological treatments in patients with heart failure with left ventricular (LV) ejection fraction≥40% from January 1996 to May 2016. The primary efficacy outcome was all-cause mortality...
August 5, 2017: Heart: Official Journal of the British Cardiac Society
Nenad Macesic, Daniel Green, Zheng Wang, Sean B Sullivan, Kevin Shim, Sarah Park, Susan Whittier, E Yoko Furuya, Angela Gomez-Simmonds, Anne-Catrin Uhlemann
The spread of mcr-1 in the United States remains poorly defined. mcr-1-producing Escherichia coli that also carried blaSHV-12 was detected in a hospitalized patient. No additional cases were identified during screening of 801 Gram-negative isolates. Genomic sequencing identified an IncX4 mcr-1- harboring plasmid and ST117 clonal background associated with avian pathogenic E coli.
2017: Open Forum Infectious Diseases
Caroline A Smith, Christopher J Zaslawski, Suzanne Cochrane, Xiaoshu Zhu, Zhen Zheng, Bertrand Loyeung, Peter C Meier, Sean Walsh, Charlie Changli Xue, Anthony L Zhang, Paul P Fahey, Alan Bensoussan
BACKGROUND: The aim of this study was to examine the reliability of a scale to assess the methodological quality of acupuncture administered in clinical research. METHODS: We invited 36 acupuncture researchers and postgraduate students to participate in the study. Firstly, participants rated two articles using the scale. Following this initial stage, modifications were made to scale items and the exercise was repeated. Interrater reliability was assessed for individual items using the Fleiss kappa statistic, whilst the overall scale used the intraclass correlation coefficient statistic...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
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