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Sean Zheng

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https://www.readbyqxmd.com/read/28937953/the-biological-basis-of-chronic-traumatic-encephalopathy-following-blast-injury-a-literature-review
#1
Matt Aldag, Regina C Armstrong, Faris Bandak, Patrick S F Bellgowan, Timothy Bentley, Sean Biggerstaff, Katrina Caravelli, Joan Cmarik, Alicia Crowder, Thomas J DeGraba, Travis A Dittmer, Richard G Ellenbogen, Colin Greene, Raj K Gupta, Ramona Hicks, Stuart Hoffman, Robert C Latta, Michael J Leggieri, Donald Marion, Robert Mazzoli, Michael McCrea, John O'Donnell, Mark Packer, James B Petro, Todd E Rasmussen, Wendy Sammons-Jackson, Richard Shoge, Victoria Tepe, Ladd A Tremaine, James Zheng
The United States Department of Defense Blast Injury Research Program Coordinating Office organized the 2015 International State-of-the-Science meeting to explore links between blast-related head injury and the development of chronic traumatic encephalopathy (CTE). Before the meeting, the planning committee examined articles published between 2005 and October 2015 and prepared this literature review, which summarized broadly CTE research and addressed questions about the pathophysiological basis of CTE and its relationship to blast- and nonblast-related head injury...
September 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28893958/microbial-derived-butyrate-promotes-epithelial-barrier-function-through-il-10-receptor-dependent-repression-of-claudin-2
#2
Leon Zheng, Caleb J Kelly, Kayla D Battista, Rachel Schaefer, Jordi M Lanis, Erica E Alexeev, Ruth X Wang, Joseph C Onyiah, Douglas J Kominsky, Sean P Colgan
Commensal interactions between the enteric microbiota and distal intestine play important roles in regulating human health. Short-chain fatty acids (SCFAs), such as butyrate, produced through anaerobic microbial metabolism represent a major energy source for the host colonic epithelium and enhance epithelial barrier function through unclear mechanisms. Separate studies revealed that the epithelial anti-inflammatory IL-10 receptor α subunit (IL-10RA) is also important for barrier formation. Based on these findings, we examined if SCFAs promote epithelial barrier through IL-10RA-dependent mechanisms...
September 11, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28884018/pp2a-b-holoenzyme-substrate-recognition-regulation-and-role-in-cytokinesis
#3
Cheng-Guo Wu, Hui Chen, Feng Guo, Vikash K Yadav, Sean J Mcilwain, Michael Rowse, Alka Choudhary, Ziqing Lin, Yitong Li, Tingjia Gu, Aiping Zheng, Qingge Xu, Woojong Lee, Eduard Resch, Benjamin Johnson, Jenny Day, Ying Ge, Irene M Ong, Mark E Burkard, Ylva Ivarsson, Yongna Xing
Protein phosphatase 2A (PP2A) is a major Ser/Thr phosphatase; it forms diverse heterotrimeric holoenzymes that counteract kinase actions. Using a peptidome that tiles the disordered regions of the human proteome, we identified proteins containing [LMFI]xx[ILV]xEx motifs that serve as interaction sites for B'-family PP2A regulatory subunits and holoenzymes. The B'-binding motifs have important roles in substrate recognition and in competitive inhibition of substrate binding. With more than 100 novel ligands identified, we confirmed that the recently identified LxxIxEx B'α-binding motifs serve as common binding sites for B' subunits with minor variations, and that S/T phosphorylation or D/E residues at positions 2, 7, 8 and 9 of the motifs reinforce interactions...
2017: Cell Discovery
https://www.readbyqxmd.com/read/28844155/effects-of-aliskiren-on-mortality-cardiovascular-outcomes-and-adverse-events-in-patients-with-diabetes-and-cardiovascular-disease-or-risk-a-systematic-review-and-meta-analysis-of-13-395-patients
#4
Sean L Zheng, Alistair J Roddick, Salma Ayis
BACKGROUND: Aliskiren was shown to increase adverse events in patients with diabetes and concomitant renin-angiotensin blockade. We aim to investigate the efficacy and safety of aliskiren in patients with diabetes and increased cardiovascular risk or established cardiovascular disease. METHODS: MEDLINE and Embase were searched for prospective studies comparing addition of aliskiren to standard medical therapy in patients with diabetes and cardiovascular disease, or ⩾1 additional cardiovascular risk factor (hypertension, abnormal lipid profile, microalbuminuria/proteinuria, chronic kidney disease)...
September 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28780577/drug-treatment-effects-on-outcomes-in-heart-failure-with-preserved-ejection-fraction-a-systematic-review-and-meta-analysis
#5
Sean Lee Zheng, Fiona T Chan, Adam A Nabeebaccus, Ajay M Shah, Theresa McDonagh, Darlington O Okonko, Salma Ayis
BACKGROUND: Clinical drug trials in patients with heart failure and preserved ejection fraction have failed to demonstrate improvements in mortality. METHODS: We systematically searched Medline, Embase and the Cochrane Central Register of Controlled Trials for randomised controlled trials (RCT) assessing pharmacological treatments in patients with heart failure with left ventricular (LV) ejection fraction≥40% from January 1996 to May 2016. The primary efficacy outcome was all-cause mortality...
August 5, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28721352/detection-of-mcr-1-carrying-escherichia-coli-causing-bloodstream-infection-in-a-new-york-city-hospital-avian-origins-human-concerns
#6
Nenad Macesic, Daniel Green, Zheng Wang, Sean B Sullivan, Kevin Shim, Sarah Park, Susan Whittier, E Yoko Furuya, Angela Gomez-Simmonds, Anne-Catrin Uhlemann
The spread of mcr-1 in the United States remains poorly defined. mcr-1-producing Escherichia coli that also carried blaSHV-12 was detected in a hospitalized patient. No additional cases were identified during screening of 801 Gram-negative isolates. Genomic sequencing identified an IncX4 mcr-1- harboring plasmid and ST117 clonal background associated with avian pathogenic E coli.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28690661/reliability-of-the-nicman-scale-an-instrument-to-assess-the-quality-of-acupuncture-administered-in-clinical-trials
#7
Caroline A Smith, Christopher J Zaslawski, Suzanne Cochrane, Xiaoshu Zhu, Zhen Zheng, Bertrand Loyeung, Peter C Meier, Sean Walsh, Charlie Changli Xue, Anthony L Zhang, Paul P Fahey, Alan Bensoussan
BACKGROUND: The aim of this study was to examine the reliability of a scale to assess the methodological quality of acupuncture administered in clinical research. METHODS: We invited 36 acupuncture researchers and postgraduate students to participate in the study. Firstly, participants rated two articles using the scale. Following this initial stage, modifications were made to scale items and the exercise was repeated. Interrater reliability was assessed for individual items using the Fleiss kappa statistic, whilst the overall scale used the intraclass correlation coefficient statistic...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28663138/the-ethanol-pathway-from-thermoanaerobacterium-saccharolyticum-improves-ethanol-production-in-clostridium-thermocellum
#8
Shuen Hon, Daniel G Olson, Evert K Holwerda, Anthony A Lanahan, Sean J L Murphy, Marybeth I Maloney, Tianyong Zheng, Beth Papanek, Adam M Guss, Lee R Lynd
Clostridium thermocellum ferments cellulose, is a promising candidate for ethanol production from cellulosic biomass, and has been the focus of studies aimed at improving ethanol yield. Thermoanaerobacterium saccharolyticum ferments hemicellulose, but not cellulose, and has been engineered to produce ethanol at high yield and titer. Recent research has led to the identification of four genes in T. saccharolyticum involved in ethanol production: adhE, nfnA, nfnB and adhA. We introduced these genes into C. thermocellum and observed significant improvements to ethanol yield, titer, and productivity...
July 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/28641978/angptl4-t266m-variant-is-associated-with-reduced-cancer-invasiveness
#9
Zhen Wei Tan, Ziqiang Teo, Carol Tan, Chee Chong Choo, Wei Sheng Loo, Yiyang Song, Zhi Yang Tam, Sean Pin Ng, Hong Zheng Koh, Yi Siang Ng, Susana Geifman Shochat, Yin Hoe Yau, Pengcheng Zhu, Nguan Soon Tan
Angiopoietin-like 4 (ANGPTL4) is a secretory protein that can be cleaved to form an N-terminal and a C-terminal protein. Studies performed thus far have linked ANGPTL4 to several cancer-related and metabolic processes. Notably, several point mutations in the C-terminal ANGPTL4 (cANGPTL4) have been reported, although no studies have been performed that ascribed these mutations to cancer-related and metabolic processes. In this study, we compared the characteristics of tumors with and without wild-type (wt) cANGPTL4 and tumors with cANGPTL4 bearing the T266M mutation (T266M cANGPTL4)...
June 19, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28622947/discontinuation-and-non-publication-of-clinical-trials-in-cardiovascular-medicine
#10
Alistair J Roddick, Fiona T S Chan, James D Stefaniak, Sean L Zheng
BACKGROUND: Appropriate dissemination of clinical data is crucial for minimising bias. Despite this, high rates of study discontinuation and non-publication have been reported among clinical trials. Cardiovascular medicine receives a substantial proportion of academic funding; however, predictors of non-publication among cardiovascular trials are not well-established. METHODS: The National Clinical Trials database was searched for cardiovascular trials completed between January 2010 and January 2014...
June 7, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28535036/reversible-bond-cation-coupled-electron-transfer-on-phenylenediamine-based-rhodamine-b-and-its-application-on-electrochromism
#11
Xiaojun Wang, Shuo Wang, Chang Gu, Weiran Zhang, Hongzhi Zheng, Jingjing Zhang, Geyu Lu, Yu-Mo Zhang, Minjie Li, Sean Xiao-An Zhang
A biomimetic system on reversible bond-coupled electron transfer (BCET) has been proposed and investigated in a switchable Rh-N molecule with redox active subunits. We discover that energy barrier of C-N bond breaking is reduced dramatically to less than 1/7 (from 40.4 to 5.5 kcal/mol), and 1/3 of the oxidation potential is simultaneously lowered (from 0.67 to 0.43 V) with the oxidation of Rh-N. The concept, cation-coupled electron transfer (CCET), is highly recommended by analyzing existing proton coupled electron transfer (PCET) and metal coupled electron transfer (MCET) along with aforementioned BCET, which have same characteristic of transferring positive charges, such as proton, metal ion, and organic cation...
May 31, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28458958/the-intersection-of-oncology-prognosis-and-cancer-rehabilitation
#12
REVIEW
Sean Robinson Smith, Jasmine Yiqian Zheng
PURPOSE OF REVIEW: This review examines the delivery of rehabilitation care to cancer patients with relation to disease prognosis. This includes the evaluation when patients are referred for rehabilitation services and the effectiveness of rehabilitation interventions across the cancer continuum. RECENT FINDINGS: Although prognosticating life expectancy is difficult, referrals for rehabilitation interventions appear to be affected by physician attitudes towards patients with advanced disease, in part because of misconceptions about the nature of rehabilitation for oncology patients...
2017: Current Physical Medicine and Rehabilitation Reports
https://www.readbyqxmd.com/read/28436610/atomic-interface-engineering-and-electric-field-effect-in-ultrathin-bi2-moo6-nanosheets-for-superior-lithium-ion-storage
#13
Yang Zheng, Tengfei Zhou, Xudong Zhao, Wei Kong Pang, Hong Gao, Sean Li, Zhen Zhou, Huakun Liu, Zaiping Guo
Ultrathin 2D materials can offer promising opportunities for exploring advanced energy storage systems, with satisfactory electrochemical performance. Engineering atomic interfaces by stacking 2D crystals holds huge potential for tuning material properties at the atomic level, owing to the strong layer-layer interactions, enabling unprecedented physical properties. In this work, atomically thin Bi2 MoO6 sheets are acquired that exhibit remarkable high-rate cycling performance in Li-ion batteries, which can be ascribed to the interlayer coupling effect, as well as the 2D configuration and intrinsic structural stability...
April 24, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28329280/implantable-cardioverter-defibrillators-for-primary-prevention-of-death-in-left-ventricular-dysfunction-with-and-without-ischaemic-heart-disease-a-meta-analysis-of-8567-patients-in-the-11-trials
#14
Matthew J Shun-Shin, Sean L Zheng, Graham D Cole, James P Howard, Zachary I Whinnett, Darrel P Francis
Aims: Primary prevention implantable cardioverter defibrillators (ICDs) are established therapy for reducing mortality in patients with left ventricular systolic dysfunction and ischaemic heart disease (IHD). However, their efficacy in patients without IHD has been controversial. We undertook a meta-analysis of the totality of the evidence. Methods and results: We systematically identified all RCTs comparing ICD vs. no ICD in primary prevention. Eligible RCTs were those that recruited patients with left ventricular dysfunction, reported all-cause mortality, and presented their results stratified by the presence of IHD (or recruited only those with or without)...
June 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28119368/gleason-score-7-prostate-cancers-emerge-through-branched-evolution-of-clonal-gleason-pattern-3-and-4
#15
Adam G Sowalsky, Haydn T Kissick, Sean J Gerrin, Rachel J Schaefer, Zheng Xia, Joshua W Russo, M Simo Arredouani, Glenn J Bubley, Martin G Sanda, Wei Li, Huihui Ye, Steven P Balk
Purpose: The molecular features that account for the distinct histology and aggressive biological behavior of Gleason pattern 4 (Gp4) versus Gp3 prostate cancer, and whether Gp3 tumors progress directly to Gp4, remain to be established.Experimental Design: Whole-exome sequencing and transcriptome profiling of laser capture-microdissected adjacent Gp3 and cribiform Gp4 were used to determine the relationship between these entities.Results: Sequencing confirmed that adjacent Gp3 and Gp4 were clonal based on multiple shared genomic alterations...
July 15, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28104689/identification-of-apilimod-as-a-first-in-class-pikfyve-kinase-inhibitor-for-treatment-of-b-cell-non-hodgkin-lymphoma
#16
Sophia Gayle, Sean Landrette, Neil Beeharry, Chris Conrad, Marylens Hernandez, Paul Beckett, Shawn M Ferguson, Talya Mandelkern, Meiling Zheng, Tian Xu, Jonathan Rothberg, Henri Lichenstein
We identified apilimod as an antiproliferative compound by high-throughput screening of clinical-stage drugs. Apilimod exhibits exquisite specificity for phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) lipid kinase and has selective cytotoxic activity in B-cell non-Hodgkin lymphoma (B-NHL) compared with normal cells. Apilimod displays nanomolar activity in vitro, and in vivo studies demonstrate single-agent efficacy as well as synergy with approved B-NHL drugs. Using biochemical and knockdown approaches, and discovery of a kinase domain mutation conferring resistance, we demonstrate that apilimod-mediated cytotoxicity is driven by PIKfyve inhibition...
March 30, 2017: Blood
https://www.readbyqxmd.com/read/27984516/ultrasound-guided-needle-biopsy-of-neck-lymph-nodes-in-patients-with-suspected-lung-cancer-are-the-specimens-sufficient-for-complete-pathologic-evaluation-to-guide-patient-management
#17
Sean Duguay, Jason M Wagner, Wei Zheng, Johnny Ling, Lichao C Zhao, Karen S Allen, Justin C North, Subrato J Deb
BACKGROUND: The purpose of this study is to determine the ability of ultrasound guided needle biopsy of a neck lymph node to provide adequate tissue for complete pathologic evaluation of suspected metastatic lung cancer, including molecular testing for epidermal growth factor receptor gene mutations by pyrosequencing and anaplastic lymphoma kinase gene rearrangement by fluorescence in situ hybridization. METHODS: Institutional review board approval was obtained and the requirement for informed consent was waived...
June 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/27983796/revealing-nanostructures-through-plasmon-polarimetry
#18
Marie-Elena Kleemann, Jan Mertens, Xuezhi Zheng, Sean Cormier, Vladimir Turek, Felix Benz, Rohit Chikkaraddy, William Deacon, Anna Lombardi, Victor V Moshchalkov, Guy A E Vandenbosch, Jeremy J Baumberg
Polarized optical dark-field spectroscopy is shown to be a versatile noninvasive probe of plasmonic structures that trap light to the nanoscale. Clear spectral polarization splittings are found to be directly related to the asymmetric morphology of nanocavities formed between faceted gold nanoparticles and an underlying gold substrate. Both experiment and simulation show the influence of geometry on the coupled system, with spectral shifts Δλ = 3 nm from single atoms. Analytical models allow us to identify the split resonances as transverse cavity modes, tightly confined to the nanogap...
December 22, 2016: ACS Nano
https://www.readbyqxmd.com/read/27919080/corrigendum-lens-regeneration-using-endogenous-stem-cells-with-gain-of-visual-function
#19
Haotian Lin, Hong Ouyang, Jie Zhu, Shan Huang, Zhenzhen Liu, Shuyi Chen, Guiqun Cao, Gen Li, Robert A J Signer, Yanxin Xu, Christopher Chung, Ying Zhang, Danni Lin, Sherrina Patel, Frances Wu, Huimin Cai, Jiayi Hou, Cindy Wen, Maryam Jafari, Xialin Liu, Lixia Luo, Jin Zhu, Austin Qiu, Rui Hou, Baoxin Chen, Jiangna Chen, David Granet, Christopher Heichel, Fu Shang, Xuri Li, Michal Krawczyk, Dorota Skowronska-Krawczyk, Yujuan Wang, William Shi, Daniel Chen, Zheng Zhong, Sheng Zhong, Liangfang Zhang, Shaochen Chen, Sean J Morrison, Richard L Maas, Kang Zhang, Yizhi Liu
No abstract text is available yet for this article.
January 26, 2017: Nature
https://www.readbyqxmd.com/read/27881084/assessing-characteristics-of-rna-amplification-methods-for-single-cell-rna-sequencing
#20
Hannah R Dueck, Rizi Ai, Adrian Camarena, Bo Ding, Reymundo Dominguez, Oleg V Evgrafov, Jian-Bing Fan, Stephen A Fisher, Jennifer S Herstein, Tae Kyung Kim, Jae Mun Hugo Kim, Ming-Yi Lin, Rui Liu, William J Mack, Sean McGroty, Joseph D Nguyen, Neeraj Salathia, Jamie Shallcross, Tade Souaiaia, Jennifer M Spaethling, Christopher P Walker, Jinhui Wang, Kai Wang, Wei Wang, Andre Wildberg, Lina Zheng, Robert H Chow, James Eberwine, James A Knowles, Kun Zhang, Junhyong Kim
BACKGROUND: Recently, measurement of RNA at single cell resolution has yielded surprising insights. Methods for single-cell RNA sequencing (scRNA-seq) have received considerable attention, but the broad reliability of single cell methods and the factors governing their performance are still poorly known. RESULTS: Here, we conducted a large-scale control experiment to assess the transfer function of three scRNA-seq methods and factors modulating the function. All three methods detected greater than 70% of the expected number of genes and had a 50% probability of detecting genes with abundance greater than 2 to 4 molecules...
November 24, 2016: BMC Genomics
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