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Ian S Kinstlinger, Jordan S Miller
Fabrication of vascular networks within engineered tissue remains one of the greatest challenges facing the fields of biomaterials and tissue engineering. Historically, the structural complexity of vascular networks has limited their fabrication in tissues engineered in vitro. Recently, however, key advances have been made in constructing fluidic networks within biomaterials, suggesting a strategy for fabricating the architecture of the vasculature. These techniques build on emerging technologies within the microfluidics community as well as on 3D printing...
May 24, 2016: Lab on a Chip
Ziqiang Yuan, Carmen Sánchez Claros, Masako Suzuki, Elaine C Maggi, Justin D Kaner, Noah Kinstlinger, Jolanta Gorecka, Thomas J Quinn, Rula Geha, Amanda Corn, Jessica Pastoriza, Qiang Jing, Asha Adem, Hao Wu, Girum Alemu, Yi-Chieh Du, Deyou Zheng, John M Greally, Steven K Libutti
Multiple endocrine neoplasia type 1 (MEN1) syndrome results from mutations in the MEN1 gene and causes tumor formation via largely unknown mechanisms. Using a novel genome-wide methylation analysis, we studied tissues from MEN1-parathyroid tumors, Men1 knockout (KO) mice, and Men1 null mouse embryonic fibroblast (MEF) cell lines. We demonstrated that inactivation of menin (the protein product of MEN1) increases activity of DNA (cytosine-5)-methyltransferase 1 (DNMT1) by activating retinoblastoma-binding protein 5 (Rbbp5)...
March 15, 2016: Oncotarget
Ian S Kinstlinger, Andreas Bastian, Samantha J Paulsen, Daniel H Hwang, Anderson H Ta, David R Yalacki, Tim Schmidt, Jordan S Miller
Selective Laser Sintering (SLS) is an additive manufacturing process that uses a laser to fuse powdered starting materials into solid 3D structures. Despite the potential for fabrication of complex, high-resolution structures with SLS using diverse starting materials (including biomaterials), prohibitive costs of commercial SLS systems have hindered the wide adoption of this technology in the scientific community. Here, we developed a low-cost, open-source SLS system (OpenSLS) and demonstrated its capacity to fabricate structures in nylon with sub-millimeter features and overhanging regions...
2016: PloS One
Jacob L Roam, Ying Yan, Peter K Nguyen, Ian S Kinstlinger, Michael K Leuchter, Daniel A Hunter, Matthew D Wood, Donald L Elbert
Peripheral nerve regeneration is a complex problem that, despite many advancements and innovations, still has sub-optimal outcomes. Compared to biologically derived acellular nerve grafts and autografts, completely synthetic nerve guidance conduits (NGC), which allow for precise engineering of their properties, are promising but still far from optimal. We have developed an almost entirely synthetic NGC that allows control of soluble growth factor delivery kinetics, cell-initiated degradability and cell attachment...
December 2015: Biomaterials
Ann-Marie Broome, Gopal Ramamurthy, Kari Lavik, Alexander Liggett, Ian Kinstlinger, James Basilion
A current limitation in molecular imaging is that it often requires genetic manipulation of cancer cells for noninvasive imaging. Other methods to detect tumor cells in vivo using exogenously delivered and functionally active reporters, such as β-gal, are required. We report the development of a platform system for linking β-gal to any number of different ligands or antibodies for in vivo targeting to tissue or cells, without the requirement for genetic engineering of the target cells prior to imaging. Our studies demonstrate significant uptake in vitro and in vivo of an EGFR-targeted β-gal complex...
April 15, 2015: Bioconjugate Chemistry
Kristy M Longpre, Noah S Kinstlinger, Edward A Mead, Yongping Wang, Austin P Thekkumthala, Katherine A Carreno, Azra Hot, Jennifer M Keefer, Luke Tully, Larry S Katz, Andrzej Z Pietrzykowski
Testosterone plays a key role in preparation of a male domesticated goat (Capra hircus) to breeding season including changes in the urogenital tract of a male goat (buck). microRNAs are important regulators of cellular metabolism, differentiation and function. They are powerful intermediaries of hormonal activity in the body, including the urogenital tract. We investigated seasonal changes in expression of microRNAs in goat buck urine and their potential consequences using next generation sequencing (microRNA-Seq)...
April 1, 2014: General and Comparative Endocrinology
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