keyword
https://read.qxmd.com/read/38462099/photothermal-superhydrophobic-conductive-and-anti-uv-cotton-fabric-loaded-with-polydimethylsiloxane-encapsulated-copper-sulfide-nanoflowers
#21
JOURNAL ARTICLE
Guolin Zheng, Zhe Jiang, Yifan Cui, Man Zhou, Yuanyuan Yu, Ping Wang, Qiang Wang
Multifunctional textiles have attracted widespread attention with the improvement of awareness of health. Especially, the fluorine-free superhydrophobic and conductive cellulose fiber-based fabrics have received intensive interest due to their broad and high-value applications. Herein, the copper sulfide nanoflowers were in-situ deposited on cotton fabric followed by polydimethylsiloxane (PDMS) treatment for encapsulating CuS nanoflowers and obtaining superhydrophobicity, recorded as Cot@PTA@CuS@PDMS. Cot@PTA@CuS@PDMS possesses superhydrophobicity with contact angles of 153...
March 8, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38442194/an-inhibitory-immunoreceptor-allergin-1-regulates-the-intestinal-dysbiosis-and-barrier-function-in-mice
#22
JOURNAL ARTICLE
Yu-Hsien Lin, Satoko Tahara-Hanaoka, Nozomu Obana, Shinji Fukuda, Akira Shibuya
The intestinal barrier consists of mucosal, epithelial, and immunological barriers and serves as a dynamic interface between the host and its environment. Disruption of the intestinal barrier integrity is a leading cause of various gastrointestinal diseases, such as inflammatory bowel disease. The homeostasis of the intestinal barrier is tightly regulated by crosstalk between gut microbes and the immune system; however, the implication of the immune system on the imbalance of gut microbes that disrupts barrier integrity remains to be fully elucidated...
March 5, 2024: International Immunology
https://read.qxmd.com/read/38441196/role-of-bacteria-and-microbial-metabolites-in-immune-modulation-during-early-life
#23
JOURNAL ARTICLE
Tine Simensen Oldereid, Xiaojun Jiang, Kathrine Sivertsen Nordhus, Andrea Ponzetta, Jørgen Vildershøj Bjørnholt, Niklas K Björkström, Espen Melum, Henrik Rasmussen
Host-microbiome interplay from birth is essential for immune imprinting and tuning. Live gut microbes and microbial-derived metabolites regulate the development and modulation of the immune system, but whether microbial metabolites solely are sufficient to induce immune maturation remains unclear. Sterile faecal filtrates (FFT) were generated from murine gut contents. Newborn germ-free (GF) mice were treated twice daily with FFT (GF-FFT) or saline (GF-NaCl) from post-natal day 5 until 4 weeks of age...
February 2024: Scandinavian Journal of Immunology
https://read.qxmd.com/read/38433446/retinoblastoma-related-1-switches-mitosis-to-meiosis-in-rice
#24
JOURNAL ARTICLE
Yongjie Miao, Hanli You, Huixin Liu, Yangzi Zhao, Jiangzhe Zhao, Yafei Li, Yi Shen, Ding Tang, Baohui Liu, Kewei Zhang, Zhukuan Cheng
The transition from mitosis to meiosis is a critical event in the reproductive development of all sexually reproducing species. However, the mechanisms regulating this process in plants remain largely unknown. We here found that the rice (Oryza sativa L.) protein RETINOBLASTOMA RELATED 1 (RBR1) was essential to the transition from mitosis to meiosis. Loss of RBR1 function resulted in hyper-proliferative sporogenous cell-like cells (SCLs) in the anther locules during early reproductive development stages. These hyper-proliferative SCLs were unable to initiate meiosis, eventually stagnating and degrading at late development stages, to form pollen-free anthers...
March 2, 2024: Plant communications
https://read.qxmd.com/read/38432539/influence-of-the-gut-microbiome-on-appetite-regulating-neuropeptides-in-the-hypothalamus-insight-from-conventional-antibiotic-treated-and-germ-free-mouse-models-of-anorexia-nervosa
#25
JOURNAL ARTICLE
Radka Roubalová, Petra Procházková, Tereza Kovářová, Janet Ježková, Tomáš Hrnčíř, Helena Tlaskalová-Hogenová, Hana Papežová
Recent research highlights the profound impact of the gut microbiome on neuropsychiatric disorders, shedding light on its potential role in shaping human behavior. In this study, we investigate the role of the gut microbiome in appetite regulation using activity-based anorexia (ABA) mouse model of anorexia nervosa (AN) - a severe eating disorder with significant health consequences. ABA was induced in conventional, antibiotic-treated, and germ-free mice. Our results show the clear influence of the gut microbiome on the expression of four orexigenic (neuropeptide Y, agouti-related peptide, melanin-concentrating hormone, and orexin) and four anorexigenic peptides (cocaine- and amphetamine-regulated transcript, corticotropin-releasing hormone, thyrotropin-releasing hormone, and pro-opiomelanocortin) in the hypothalamus...
March 1, 2024: Neurobiology of Disease
https://read.qxmd.com/read/38430737/establishment-of-a-transgene-free-ips-cell-line-sdchi003-a-from-a-young-patient-bearing-a-nprl2-mutation-and-suffering-from-epilepsy
#26
JOURNAL ARTICLE
Song Su, Fen Zhao, Hongwei Zhang, Yi Liu, Zilong Li, Huan Zhang, Yaping Wang, Fang Fang, Yong Liu
Epilepsy affects ∼ 65 million people worldwide. Status epilepticus can lead to life-threatening if untreated. In this study, peripheral blood mononuclear cells were isolated from a young patient patient bearing a Nitrogen Perntease Regulator Like 2 Protein (NPRL2) mutation and suffering from Epilepsy verified by clinical and genetic diagnosis. Induced pluripotent stem cells (iPSCs) were established by a non-integrative method, using plasmids carrying OCT4, SOX2, KLF4, BCL-XL and C-MYC. The established iPSCs presented typical pluripotent cells morphology, normal karyotype, and potential to differentiate into three germ layers...
February 28, 2024: Stem Cell Research
https://read.qxmd.com/read/38412659/generation-of-induced-pluripotent-stem-cell-line-nimhi010-a-from-dermal-fibroblast-cells-of-a-healthy-individual
#27
JOURNAL ARTICLE
Suravi Sasmita Dash, Gautham Arunachal, Madhura Milind Nimonkar, Seena Vengalil, Saraswati Nashi, Ghati K Chetan, Vijay Kumar Boddu, Atchayaram Nalini, Yogananda S Markandeya
In this study, we have established human induced pluripotent stem cell (hiPSC) line, NIMHi010-A of a 42-year-old healthy donor. The iPSC line was generated from human dermal fibroblasts using Sendai viruses carrying reprogramming factors c-MYC, SOX2, KLF4, and OCT4 under a feeder-free culture system. The generated hiPSC line expressed typical pluripotency markers, displayed a normal karyotype, and demonstrated the potential to differentiate into the three germ layers. This hiPSC line will serve as a healthy control model for physiological processes and drug screening of Asian origin from Indian population...
February 23, 2024: Stem Cell Research
https://read.qxmd.com/read/38409885/whole-exome-sequencing-has-revealed-novel-genetic-characteristics-in-intracranial-germ-cell-tumours-in-the-chinese
#28
JOURNAL ARTICLE
Xiang Huang, Jianhan Huang, Xiaoyu Zhou, Chao Zhang, Xinghua Ding, Peter Jih Cheng Wong, Yang Wang, Rong Zhang
AIMS: Intracranial germ cell tumour (IGCT) is a type of rare central nervous system tumour that mainly occurs in children and adolescents, with great variation in its incidence rate and molecular characteristics in patients from different populations. The genetic alterations of IGCT in the Chinese population are still unknown. METHODS AND RESULTS: In this study, 47 patients were enrolled and their tumour specimens were analysed by whole-exome sequencing (WES). We found that KIT was the most significantly mutated gene (15/47, 32%), which mainly occurred in the germinoma group (13/20, 65%), and less frequently in NGGCT (2/27, 7%)...
February 26, 2024: Histopathology
https://read.qxmd.com/read/38403884/categorization-of-the-effects-of-e-%C3%A2-coli-lf82-and-mutants-lacking-the-chut-and-shuu-genes-on-survival-the-transcriptome-and-metabolome-in-germ-free-honeybee
#29
JOURNAL ARTICLE
Dongping Feng, Hujun Zhang, Zhengpeng Li, Yiyuan Li, Jingshuang Yan, Yan Zhang, Yunsheng Yang
The precise etiology of inflammatory bowel diseases (IBDs) remains elusive. The Escherichia coli strain LF82 (LF82) is known to be associated with IBD, and we hypothesized that this association may be related to the chuT and shuU genes. Here we constructed a germ-free (GF) honeybee model to investigate the effects of LF82 chuT and shuU genes on the honeybee intestine and their mechanisms. The chuT and shuU gene deletion strains LF82∆chuT and LF82∆shuU were generated by CRISPR-Cas9. These strains, together with nonpathogenic E...
February 25, 2024: FEBS Open Bio
https://read.qxmd.com/read/38400709/heart-failure-induced-microbial-dysbiosis-contributes-to-colonic-tumour-formation-in-mice
#30
JOURNAL ARTICLE
Sanne de Wit, Lotte Geerlings, Canxia Shi, Just Dronkers, Elisabeth M Schouten, Gillian Blancke, Vanessa Andries, Tess Yntema, Wouter C Meijers, Debby P Y Koonen, Lars Vereecke, Herman H W Silljé, Joseph-Pierre Aboumsallem, Rudolf A de Boer
INTRODUCTION: Heart failure (HF) and cancer are the leading causes of death worldwide. Epidemiological studies revealed that HF patients are prone to develop cancer. Preclinical studies provided some insights into this connection, but the exact mechanisms remain elusive. In colorectal cancer (CRC), gut microbial dysbiosis is linked to cancer progression and recent studies have shown that HF patients display microbial dysbiosis. AIM: This current study focussed on the effects of HF-induced microbial dysbiosis on colonic tumour formation...
February 24, 2024: Cardiovascular Research
https://read.qxmd.com/read/38394499/therapeutic-efficacy-of-high-dose-chemotherapy-with-autologous-stem-cell-transplantation-in-44-relapsed-or-refractory-germ-cell-tumor-patients-a-retrospective-cohort-study
#31
JOURNAL ARTICLE
Ferhat Ferhatoglu, Nail Paksoy, Nijat Khanmammadov, Anil Yildiz, Melin Aydan Ahmed, Zafer Gülbas, Mert Basaran
Despite having a higher mortality risk than conventional chemotherapeutics, high-dose chemotherapy (HDCT) has the potential to be curative in relapsed/refractory germ-cell tumors. Therefore, selecting the best patient group for this treatment is critical. This study aimed to determine the factors that affect survival in our relapsed/refractory GCT cohort who received HDCT and autologous stem-cell transplantation. Between September 2010 and 2020, we included in the study 44 relapsed/refractory male patients with GCT treated with HDCT plus autologous stem-cell transplantation...
February 23, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38379939/basis-for-the-diversity-and-extent-in-loss-of-digestible-nutrients-created-by-dietary-phytin-emphasis-on-fowl-and-swine
#32
REVIEW
Edwin T Moran, Michael R Bedford
Phytin is the Ca2+ -Mg2+ -K+ salt of phytic acid that is created and deposited in the aleurone layer and/or germ of grains and legumes. Its high presence in feedstuffs for fowl and swine diets results in it being a universal and significant impediment to optimum performance. Phytin impairs gastrointestinal recovery of a wide array of nutrients, the effect varying with the nutrient concerned. On exposure to low pH during gastric digestion, phytin dissociates into phytic acid and solubilized Ca2+ . Even at low gastric pH, phytic acid is negatively charged which forms the basis of its anti-nutritive behavior...
March 2024: Animal Nutrition
https://read.qxmd.com/read/38378622/gut-dysbiosis-induces-the-development-of-depression-like-behavior-through-abnormal-synapse-pruning-in-microglia-mediated-by-complement-c3
#33
JOURNAL ARTICLE
Wenzhi Hao, Qingyu Ma, Lu Wang, Naijun Yuan, Hua Gan, Liangliang He, Xiaojuan Li, Junqing Huang, Jiaxu Chen
BACKGROUND: Remodeling eubiosis of the gut microenvironment may contribute to preventing the occurrence and development of depression. Mounting experimental evidence has shown that complement C3 signaling is associated with the pathogenesis of depression, and disruption of the gut microbiota may be an underlying cause of complement system activation. However, the mechanism by which complement C3 participates in gut-brain crosstalk in the pathogenesis of depression remains unknown. RESULTS: In the present study, we found that chronic unpredictable mild stress (CUMS)-induced mice exhibited obvious depression-like behavior as well as cognitive impairment, which was associated with significant gut dysbiosis, especially enrichment of Proteobacteria and elevation of microbiota-derived lipopolysaccharides (LPS)...
February 20, 2024: Microbiome
https://read.qxmd.com/read/38377649/an-integration-free-ipsc-line-sdqlchi065-a-from-a-patient-with-down-syndrome-possessing-a-47-xy-21-inv-9-p12q21-16qh%C3%A2-%C3%A2-karyotype
#34
JOURNAL ARTICLE
Xue Zhang, Hongmei Xin, Yi Liu, Zhongtao Gai, Zilong Li
Down syndrome, a chromosomal aneuploidy genetic disorder, is primarily caused by trisomy 21 in all cells of a patient's body. In fewer cases, it can be attributed to a trisomy 21 chimera or trisomy 21 in specific cells within the body. We established an induced pluripotent stem cell (iPSC) line from the peripheral blood mononuclear cells (PBMCs) of an 8-day-old boy with Down syndrome possessing a 47, XY,+21, inv(9)(p12q21),16qh + karyotype. The iPSCs exhibited consistent karyotype, expressed markers indicative of pluripotency, lacked genomic integration of episomal plasmids, and demonstrated in vitro differentiation potential across three germ layers...
February 17, 2024: Stem Cell Research
https://read.qxmd.com/read/38373348/11-plex-dileu-isobaric-labeling-enables-quantitative-assessment-of-brain-region-protein-association-networks-impacted-by-the-gut-microbiome
#35
JOURNAL ARTICLE
Shuying Han, Zihui Li, Yatao Shi, Yusi Cui, Junfeng Huang, Dustin C Frost, Federico E Rey, Rui Liu, Lingjun Li
Gut microbiota can regulate host brain functions and influence various physiological and pathological processes through the brain-gut axis. To systematically elucidate the intervention of different gut environments on different brain regions, we implemented an integrated approach that combines 11-plex DiLeu isobaric tags with a "BRIDGE" normalization strategy to comparatively analyze the proteome of six brain regions in germ-free (GF)- and conventionally raised (ConvR)-mice. A total of 5945 proteins were identified and 5656 were quantifiable, while 1906 of them were significantly changed between GF- and ConvR-mice; 281 proteins were filtered with FC greater than 1...
February 19, 2024: Analytical Chemistry
https://read.qxmd.com/read/38372391/colonic-ketogenesis-a-microbiota-regulated-process-contributes-to-blood-ketones-and-protects-against-colitis-in-mice
#36
JOURNAL ARTICLE
Kevin Bass, Sathish Sivaprakasam, Gunadharini Dharmalingam-Nandagopal, Muthusamy Thangaraju, Vadivel Ganapathy
Ketogenesis is considered to occur primarily in liver to generate ketones as an alternative energy source for non-hepatic tissues when glucose availability/utilization is impaired. 3-Hydroxy-3-methylglutaryl-CoA synthase-2 (HMGCS2) mediates the rate-limiting step in this mitochondrial pathway. Publicly available databases show marked down-regulation of HMGCS2 in colonic tissues in Crohn's disease and ulcerative colitis. This led us to investigate the expression and function of this pathway in colon and its relevance to colonic inflammation in mice...
February 21, 2024: Biochemical Journal
https://read.qxmd.com/read/38371620/outcome-of-patients-with-stage-i-immature-teratoma-after-surveillance-or-adjuvant-chemotherapy
#37
JOURNAL ARTICLE
Giuseppe Marino, Tommaso Grassi, Elena De Ponti, Serena Negri, Filippo Testa, Daniela Giuliani, Martina Delle Marchette, Cristina Dell'Oro, Diletta Fumagalli, Gianluca Donatiello, Giulia Besana, Liliana Marchetta, Cristina Maria Bonazzi, Andrea Alberto Lissoni, Fabio Landoni, Robert Fruscio
OBJECTIVE: Immature teratomas are rare malignant ovarian germ cell tumours, typically diagnosed in young women, where fertility-sparing surgery is the treatment of choice. The role of adjuvant chemotherapy in stage I disease remains controversial. We evaluated the impact of surveillance versus chemotherapy on the recurrence rate in stage I immature teratomas. METHODS: We collected a single centre retrospective series of patients with stage I immature teratomas treated with fertility-sparing surgery at San Gerardo Hospital, Monza, Italy, between 1980 and 2019...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38368738/generation-of-induced-pluripotent-stem-cell-line-nimhi009-a-from-pbmcs-of-an-adult-healthy-male
#38
JOURNAL ARTICLE
Gautham Arunachal, Madhura Milind Nimonkar, Kenchaiah Raghavendra, Ghati K Chetan, Bhupesh Mehta, Yogananda S Markandeya
Human induced pluripotent stem cells provide an exceptional platform for studying pathogenesis in vitro. We, therefore, have generated and characterized human induced pluripotent stem cell (iPSC) line NIMHi009-A derived from peripheral blood mononuclear cells (PBMCs) of healthy adult male control for an epileptic patient carrying voltage gated sodium channel mutation, using Sendai virus-based reprogramming. The generated iPSCs express pluripotency genes and can spontaneously differentiate into three germ layers...
February 16, 2024: Stem Cell Research
https://read.qxmd.com/read/38366194/characterizing-core-microbiota-and-regulatory-functions-of-the-pig-gut-microbiome
#39
JOURNAL ARTICLE
Jun Hu, Jianwei Chen, Libao Ma, Qiliang Hou, Yong Zhang, Xiangfeng Kong, Xingguo Huang, Zhonglin Tang, Hong Wei, Xiangru Wang, Xianghua Yan
Domestic pigs (Sus scrofa) are the leading terrestrial animals used for meat production. The gut microbiota significantly affect host nutrition, metabolism, and immunity. Hence, characterization of the gut microbial structure and function will improve our understanding of gut microbial resources and the mechanisms underlying host-microbe interactions. Here, we investigated the gut microbiomes of seven pig breeds using metagenomics and 16S rRNA gene amplicon sequencing. We established an expanded gut microbial reference catalog comprising 17 020 160 genes and identified 4910 metagenome-assembled genomes (MAGs)...
January 12, 2024: ISME Journal
https://read.qxmd.com/read/38361932/microbiota-modulates-the-steroid-response-to-acute-immune-stress-in-male-mice
#40
JOURNAL ARTICLE
Karla Vagnerová, Taťána Gazárková, Martin Vodička, Peter Ergang, Petra Klusoňová, Tomáš Hudcovic, Dagmar Šrůtková, Petra Petr Hermanová, Lucie Nováková, Jiří Pácha
Microbiota plays a role in shaping the HPA-axis response to psychological stressors. To examine the role of microbiota in response to acute immune stressor, we stimulated the adaptive immune system by anti-CD3 antibody injection and investigated the expression of adrenal steroidogenic enzymes and profiling of plasma corticosteroids and their metabolites in specific pathogen-free (SPF) and germ-free (GF) mice. Using UHPLC-MS/MS, we showed that 4 hours after immune challenge the plasma levels of pregnenolone, progesterone, 11-deoxycorticosterone, corticosterone (CORT), 11-dehydroCORT and their 3α/β-, 5α-, and 20α-reduced metabolites were increased in SPF mice, but in their GF counterparts, only CORT was increased...
2024: Frontiers in Immunology
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