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Haroon Latif Khan, Shahzad Bhatti, Sana Abbas, Yousaf Latif Khan, Rosa Maria Marquez Gonzalez, Muhammad Aslamkhan, Gerardo Rodriguez Gonzalez, Hikmet Hakan Aydin
Background: Despite its worldwide high occurrence, the obscurity regarding the description, epidemiology and management of premature ejaculation remains provocative. It is well established that male premature ejaculatory dysfunction is an increasing problem due to spontaneous ejaculation across a variety of general and clinical subjects. The main goal of this study was to determine the relationships between trinucleotide repeats of the androgen receptor (AR), sex steroids, and pituitary hormones with sexual function in men with type 2 diabetes mellitus (DM) and reported with acquired premature ejaculation (PE)...
2018: Basic and Clinical Andrology
Larisa G Poddubnaya, Willy Hemmingsen, Magdaléna Bruñanská, David I Gibson
This investigation of Calicotyle affinis is the first ultrastructural description of the male reproductive system of a monocotylid monogenean. It has revealed numerous characteristics which are either new or clarify those determined from previous light microscopical observations on the morphology of Calicotyle spp. These include numerous individual testes, each surrounded by its own basal lamina; an ejaculatory bulb delimited by a basal lamina surrounded by two independent internal and external bands of muscles; a bipartite, but not fully divided, muscular chamber (an internal seminal vesicle) in the proximal region of the ejaculatory bulb; well-developed unicellular prostatic glands localised outside the ejaculatory bulb, the cytoplasmic extensions of which pass into the ejaculatory bulb, to form the ducts which open into the lumen of ejaculatory duct; and a male copulatory organ in the form of a coiled penis tube containing throughout its lumen a long, hollow stylet...
March 18, 2018: Parasitology Research
John S Wiener, Dominic C Frimberger, Hadley Wood
Until recently, spina bifida has been regarded a pediatric health issue, and adult consequences of the disorder have not been explored. The congenital neurologic and urologic anomalies, as well as sequelae of bladder management, can have a profound impact on adult male sexual function. Abnormalities in testicular descent, testicular development and function, fertility, penile sensation, erectile function, ejaculatory function, and orgasmic function are common in this population. These adults have substantial gaps in knowledge in normal sexual function and potential dysfunction as it relates to them specifically...
March 12, 2018: Urology
Jia-Dong Xia, Jie Chen, Bai-Bing Yang, Hai-Jian Sun, Guo-Qing Zhu, Yu-Tian Dai, Jie Yang, Zeng-Jun Wang
Differences in intravaginal ejaculation latency reflect normal biological variation, but the causes are poorly understood. Here, we investigated whether variation in ejaculation latency in an experimental rat model is related to altered sympathetic nervous system (SNS) activity and expression of N-methyl-D-aspartic acid (NMDA) receptors in the paraventricular nucleus of the hypothalamus (PVN). Male rats were classified as "sluggish," "normal," and "rapid" ejaculators on the basis of ejaculation frequency during copulatory behavioral testing...
March 6, 2018: Asian Journal of Andrology
Lütfi Canat, Recep Burak Değirmentepe, Hasan Anıl Atalay, İlter Alkan, Sait Özbir, Mehmet Gökhan Çulha, Alper Ötünçtemur
PURPOSE: The aim of this prospective, observational study was to investigate the relationship between premature ejaculation (PE) and female sexual response cycle, using the female sexual function index (FSFI). The FSFI evaluates female sexual function in six domains: desire, arousal, lubrication, orgasm, satisfaction, and pain. METHODS: All men were considered to have PE if they fulfilled the criteria of the second Ad Hoc International Society for Sexual Medicine (ISSM) Committee...
March 1, 2018: International Urology and Nephrology
Giuseppe Magistro, Christian G Stief, Henry H Woo
CONTEXT: Lower urinary tract symptoms (LUTS) are one of the most common benign conditions affecting aging men. Among surgical procedures, minimally invasive treatment options have emerged with the main objective to be at least equally effective as current standard techniques, but with a more favourable safety profile. OBJECTIVE: To present the technical principle for prostatic urethral lift (PUL) and review clinical outcomes. EVIDENCE ACQUISITION: Medline, PubMed, the Cochrane database, and Embase were screened for randomised controlled trials, clinical trials, and reviews on PUL...
February 20, 2018: European Urology Focus
M T Yakubu, A R Atoyebi
The effects of aqueous extract of Brysocarpus coccineus roots (AEBCR) were studied on sexual behaviour and testicular function of paroxetine-induced sexual dysfunction (SD) in male rats. Ninety, sexually matured male rats (150.88 ± 5.53 g) were assigned into two groups: A and B. Fifteen SD animals from group B were each allotted to B1, B2, B3, B4 and B5 and received distilled water (DW), Powmax M (7.14 mg/kg body weight, b.w.) 50, 100 and 150 mg/kg b.w of AEBCR, respectively, for 7 days while the non-SD animals (group A) received DW...
February 22, 2018: Andrologia
José Beirão, Jason A Lewis, Brendan F Wringe, Craig F Purchase
Reproduction of external fertilizing vertebrates is typically constrained to either fresh or salt water, not both. For all studied amphibians and fishes, this constraint includes immotile sperm that are activated after ejaculation only by the specific chemistry of the fertilizing medium in which the species evolved (fresh, brackish, or salt water). No amphibians can reproduce in the sea. Although diadromous fishes may migrate between salt and fresh water, they are shackled to their natal environment for spawning in part because of sperm activation...
February 2018: Ecology and Evolution
Connor M Forbes, Ryan Flannigan, Darius A Paduch
BACKGROUND: Ejaculation consists of the emission of semen from seminal vesicles and prostate, followed by expulsion. Ejaculatory dysfunction may take several forms including premature ejaculation, delayed or anejaculation, retrograde ejaculation, and painful ejaculation. Ejaculation is what we can see whereas orgasm is what we feel. The presence of ejaculate does not indicate the ability to experience orgasm. Hence, for the purpose of this work we consider orgasm and ejaculation as 2 separate neurobiological phenomena...
February 17, 2018: Sexual Medicine Reviews
Martin Schoenthaler, Karl-Dietrich Sievert, Dominik Stefan Schoeb, Arkadiusz Miernik, Thomas Kunit, Simon Hein, Thomas R W Herrmann, Konrad Wilhelm
PURPOSE: The aim of the study was to evaluate the feasibility and safety of combining prostatic urethral lift (PUL) and a limited resection of the prostatic middle lobe or bladder neck incision in the treatment of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). METHODS: Twenty-eight patients were treated at two tertiary centers and followed prospectively. Patient evaluations included patient characteristics, relief of LUTS symptoms, erectile and ejaculatory function, continence, operative time and adverse events...
February 15, 2018: World Journal of Urology
Konrad Stolz, Johannes Strauß, Joscha Arne Alt, Reinhard Lakes-Harlan
This study investigates the neuroanatomy of the defense gland and a related muscle in the stick insect Peruphasma schultei with axonal tracing and histological sections. The gland is innervated by three neurons through the Nervus anterior of the suboesophageal ganglion (SOG), the ipsilateral neuron (ILN), the contralateral neuron (CLN) and the prothoracic intersegmental neuron (PIN). The ILN has a large soma which is typical for motoneurons that cause fast contraction of large muscles and its dendrites are located in motor-sensory and sensory neuropile areas of the SOG...
February 10, 2018: Arthropod Structure & Development
Gajanan S Bhat, S Anuradha
OBJECTIVE: To evaluate the proposed novel tools, namely, Arousal to Ejaculation Time Interval (AETI) and Erection to Ejaculation Time Interval (EETI), to measure ejaculatory latency during different types of sexual encounters, in a pilot study. METHODS: The study period was from September 2016 to December 2016. After obtaining informed consent and institutional review board approval, the medical practitioners without any co-morbidity, who volunteered to participate, were asked to report the self assessed time taken to ejaculate following sexual arousal (AETI) and also following a sustained erection (EETI) during a sexual activity...
February 9, 2018: Urology
Qi-Hui Lyu, Bei-Bei Zhang, Bao-Zhen Hua
The fine structure of the seminal vesicle and reproductive accessory glands was investigated in Bittacidae of Mecoptera using light and transmission electron microscopy. The male reproductive system of Bittacidae mainly consists of a pair of testes, a pair of vasa deferentia, and an ejaculatory sac. The vas deferens is greatly expanded for its middle and medio-posterior parts to form a well-developed seminal vesicle. The seminal vesicle is composed of layers of developed muscles and a mono-layered epithelium surrounding the small central lumen...
February 6, 2018: Arthropod Structure & Development
Joseph H Yacoub, Aytekin Oto
McNeal first described the zonal anatomy of the prostate about 40 years ago, outlining 4 zones of the prostate and defining their relation to the urethra and the ejaculatory ducts. The zonal anatomy remains the accepted model for describing the prostate and the zones are well-depicted on MR imaging, including the central zone, which until recently was grouped with the transition zone in the radiology literature. An accurate understanding of the zonal anatomy and periprostatic anatomy is key for accurate interpretation of the prostate MR imaging...
March 2018: Radiologic Clinics of North America
Nora M Haney, Laith M Alzweri, Wayne J G Hellstrom
BACKGROUND: Pelvic surgeries are recognized to cause dysfunction of the male sexual response, which consists of erection, emission, expulsion, and orgasm. However, the least attention has been paid to male orgasmic dysfunction after invasive pelvic surgery. AIM: To describe the available literature on post-pelvic surgery orgasmic dysfunction disorders. METHODS: A literature search was performed on PubMed using the search strings related to dysfunction of the male sexual cycle and orgasm after pelvic surgery...
January 25, 2018: Sexual Medicine Reviews
Vikash Kumar, Chirag Punatar, Kunal Jadhav, Sharad Sagade
Prostatic utricle cyst is a rare congenital anomaly. Symptomatic cysts require treatment. Surgical excision is the treatment of choice, but is challenging due to close proximity to vas deferens, ejaculatory ducts, bladder, prostate, rectum and pelvic nerves. Complications include rectal injury, ureteral injury, impotence, infertility and faecal incontinence. We here report a rare complication in which bladder was accidentally removed during laparoscopic excision of prostatic utricle cyst. To best of our knowledge such a complication has never been reported previously...
January 26, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Mariangela Allocca, Daniela Gilardi, Gionata Fiorino, Federica Furfaro, Laurent Peyrin-Biroulet, Silvio Danese
There has been considerable literature on sexual issues in women with inflammatory bowel disease (IBD), but relatively little attention has been paid to these aspects in men. To review the available literature and to provide the best management of sexual and reproductive issues in male patients with IBD. The scientific literature on sexual and reproductive issues in men with IBD was reviewed. Several factors, including surgical and medication treatments, disease activity, lifestyle, and psychological factors, may play a role in the development of infertility and sexual dysfunction and may negatively impact pregnancy outcomes...
January 18, 2018: European Journal of Gastroenterology & Hepatology
Mohmmad-Nabi Moradi, Jamshid Karimi, Iraj Khodadadi, Iraj Amiri, Manoochehr Karami, Massoud Saidijam, Akram Vatannejad, Heidar Tavilani
Thioredoxin (Trx) system has a defensive role against the harmful effect of oxidative stress in sperm. p53 is an important regulator of apoptosis and normal process of spermatogenesis. Regulation of p53 by redox state of the cell and Thioredoxin system has been reported. The aim of this study was to evaluate the ROS level, Thioredoxin reductase (TrxR) activity and p53 protein levels in sperm of asthenozoospermic and normozoospermic males. Semen samples from 80 donors were divided into asthenozoospermic (n=40) and normozoospermic (n=40) groups using the WHO criteria...
January 2, 2018: Free Radical Biology & Medicine
Odunayo Kalejaiye, Khaled Almekaty, Gideon Blecher, Suks Minhas
Premature ejaculation remains a difficult condition to manage for patients, their partners, and the clinician. Whilst prevalence rates are estimated to be 20-40%, determining a diagnosis of premature ejaculation is difficult, as the definition remains both subjective and ill-defined in the clinical context. As our understanding of the ejaculatory pathway has improved, new opportunities to treat the condition have evolved with mixed results. In this review, we explore some of these controversies surrounding the aetiology, diagnosis, and treatment of this condition and discuss potential novel therapeutic options...
2017: F1000Research
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