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tissue resident memory t cells

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https://www.readbyqxmd.com/read/29677387/il13r%C3%AE-2-expression-identifies-tissue-resident-il-22-producing-plzf-innate-t-cells-in-the-human-liver
#1
Dominic Paquin-Proulx, Benjamin C Greenspun, Lise Pasquet, Benedikt Strunz, Soo Aleman, Karolin Falconer, Masaki Terabe, Jay A Berzofsky, Johan K Sandberg, Espen Melum, Douglas F Nixon, Niklas K Björkström
Innate lymphocytes are selectively enriched in the liver where they have important roles in liver immunology. Murine studies have shown that type I NKT cells can promote liver inflammation whereas type II NKT cells have an anti-inflammatory role. In humans, type II NKT cells were found to accumulate in the gut during inflammation and IL13Rα2 was proposed as a marker for these cells. In the human liver, less is known about type I and II NKT cells. Here, we studied the phenotype and function of human liver T cells expressing IL13Rα2...
April 20, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29673645/intranasal-delivery-of-adjuvant-free-peptide-nanofibers-elicits-resident-cd8-t-cell-responses
#2
Youhui Si, Yi Wen, Sean H Kelly, Anita S Chong, Joel H Collier
Influenza vaccines that can be administered intranasally or by other needle-free delivery routes have potential advantages over injected formulations in terms of patient compliance, cost, and ease of global distribution. Supramolecular peptide nanofibers have been investigated previously as platforms for vaccines and immunotherapies and have been shown to raise immune responses in the absence of exogenous adjuvants and without measurable inflammation. However, at present it has not been tested whether the immunogenicity of these materials extends to the intranasal route...
April 16, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29664571/tissue-resident-memory-t-cells-in-tissue-homeostasis-persistent-infection-and-cancer-surveillance
#3
REVIEW
Thomas Gebhardt, Umaimainthan Palendira, David C Tscharke, Sammy Bedoui
A large proportion of memory T cells disseminated throughout the body are non-recirculating cells whose maintenance and function is regulated by tissue-specific environmental cues. These sessile cells are referred to as tissue-resident memory T (TRM ) cells and similar populations of non-recirculating cells also exist among unconventional T cells and innate lymphocyte cells. The pool of TRM cells is highly diverse with respect to anatomical positioning, phenotype, molecular regulation and effector function...
May 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29664568/the-role-of-cytokines-in-t-cell-memory-in-health-and-disease
#4
REVIEW
Miro E Raeber, Yves Zurbuchen, Daniela Impellizzieri, Onur Boyman
Upon stimulation with their cognate antigen, naive T cells undergo proliferation and differentiation into effector cells, followed by apoptosis or survival as precursors of long-lived memory cells. These phases of a T-cell response and the ensuing maintenance of memory T cells are shaped by cytokines, most notably interleukin-2 (IL-2), IL-7, and IL-15 that share the common γ chain (γc ) cytokine receptor. Steady-state production of IL-7 and IL-15 is necessary for background proliferation and homeostatic survival of CD4+ and CD8+ memory T cells...
May 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29664565/memory-cd8-t-cell-inflation-vs-tissue-resident-memory-t-cells-same-patrollers-same-controllers
#5
REVIEW
Suzanne P M Welten, Ioana Sandu, Nicolas S Baumann, Annette Oxenius
The induction of long-lived populations of memory T cells residing in peripheral tissues is of considerable interest for T cell-based vaccines, as they can execute immediate effector functions and thus provide protection in case of pathogen encounter at mucosal and barrier sites. Cytomegalovirus (CMV)-based vaccines support the induction and accumulation of a large population of effector memory CD8 T cells in peripheral tissues, in a process called memory inflation. Tissue-resident memory (TRM ) T cells, induced by various infections and vaccination regimens, constitute another subset of memory cells that take long-term residence in peripheral tissues...
May 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29664561/the-function-and-dysfunction-of-memory-cd8-t-cells-in-tumor-immunity
#6
REVIEW
James L Reading, Felipe Gálvez-Cancino, Charles Swanton, Alvaro Lladser, Karl S Peggs, Sergio A Quezada
The generation and maintenance of CD8+ T cell memory is crucial to long-term host survival, yet the basic tenets of CD8+ T cell immunity are still being established. Recent work has led to the discovery of tissue-resident memory cells and refined our understanding of the transcriptional and epigenetic basis of CD8+ T cell differentiation and dysregulation. In parallel, the unprecedented clinical success of immunotherapy has galvanized an intense, global research effort to decipher and de-repress the anti-tumor response...
May 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29625895/klrg1-effector-cd8-t-cells-lose-klrg1-differentiate-into-all-memory-t-cell-lineages-and-convey-enhanced-protective-immunity
#7
Dietmar Herndler-Brandstetter, Harumichi Ishigame, Ryo Shinnakasu, Valerie Plajer, Carmen Stecher, Jun Zhao, Melanie Lietzenmayer, Lina Kroehling, Akiko Takumi, Kohei Kometani, Takeshi Inoue, Yuval Kluger, Susan M Kaech, Tomohiro Kurosaki, Takaharu Okada, Richard A Flavell
Protective immunity against pathogens depends on the efficient generation of functionally diverse effector and memory T lymphocytes. However, whether plasticity during effector-to-memory CD8+ T cell differentiation affects memory lineage specification and functional versatility remains unclear. Using genetic fate mapping analysis of highly cytotoxic KLRG1+ effector CD8+ T cells, we demonstrated that KLRG1+ cells receiving intermediate amounts of activating and inflammatory signals downregulated KLRG1 during the contraction phase in a Bach2-dependent manner and differentiated into all memory T cell linages, including CX3 CR1int peripheral memory cells and tissue-resident memory cells...
March 31, 2018: Immunity
https://www.readbyqxmd.com/read/29621697/transcriptional-programming-of-tissue-resident-memory-cd8-t-cells
#8
REVIEW
J Justin Milner, Ananda W Goldrath
Tissue-resident memory CD8+ T cells (TRM ) are localized in non-lymphoid tissues throughout the body where they mediate long-lived protective immunity at common sites of pathogen exposure. As the signals controlling TRM differentiation are uncovered, it is becoming apparent that the dynamic activities of numerous transcription factors are intricately involved in TRM formation. Here, we highlight known transcriptional regulators of TRM differentiation and discuss how understanding the transcriptional programming of CD8+ T cell residency in non-lymphoid tissues can be leveraged to prevent or treat disease...
April 2, 2018: Current Opinion in Immunology
https://www.readbyqxmd.com/read/29603342/indeterminate-pediatric-acute-liver-failure-is-uniquely-characterized-by-a-cd103-cd8-t-cell-infiltrate
#9
Catherine A Chapin, Thomas Burn, Tomas Meijome, Kathleen M Loomes, Hector Melin-Aldana, Portia A Kreiger, Peter F Whitington, Edward M Behrens, Estella M Alonso
The cause of pediatric acute liver failure (PALF) is unknown in up to 40% of cases. Evidence suggests aberrant immune system activation may play a role. We hypothesized indeterminate PALF cases would exhibit a unique pattern of hepatic inflammation. This was a retrospective and prospective study of PALF cases due to indeterminate (iPALF), autoimmune hepatitis (AIH), or known diagnosis (dPALF) etiology. Liver tissue sections were stained with immunohistochemical (IHC) markers for cytotoxic T-cells (CD8), perforin, and tissue resident memory T-cells (CD103), and scored as minimal, moderate, or dense...
March 30, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29593708/mucosal-delivery-of-fusion-proteins-with-bacillus-subtilis-spores-enhances-protection-against-tuberculosis-by-bacillus-calmette-gu%C3%A3-rin
#10
Alastair Copland, Gil R Diogo, Peter Hart, Shane Harris, Andy C Tran, Mathew J Paul, Mahavir Singh, Simon M Cutting, Rajko Reljic
Tuberculosis (TB) is the most deadly infectious disease in existence, and the only available vaccine, Bacillus Calmette-Guérin (BCG), is almost a century old and poorly protective. The immunological complexity of TB, coupled with rising resistance to antimicrobial therapies, necessitates a pipeline of diverse novel vaccines. Here, we show that Bacillus subtilis spores can be coated with a fusion protein 1 ("FP1") consisting of Mycobacterium tuberculosis (Mtb) antigens Ag85B, ACR, and HBHA. The resultant vaccine, Spore-FP1, was tested in a murine low-dose Mtb aerosol challenge model...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29570776/the-roles-of-resident-central-and-effector-memory-cd4-t-cells-in-protective-immunity-following-infection-or-vaccination
#11
REVIEW
Joshua I Gray, Lotus M Westerhof, Megan K L MacLeod
Immunological memory provides rapid protection to pathogens previously encountered through infection or vaccination. CD4 T cells play a central role in all adaptive immune responses. Vaccines must, therefore, activate CD4 T cells if they are to generate protective immunity. For many diseases, we do not have effective vaccines. These include HIV, tuberculosis and malaria, which are responsible for many millions of deaths each year across the globe. CD4 T cells play many different roles during the immune response coordinating the actions of many other cells...
March 23, 2018: Immunology
https://www.readbyqxmd.com/read/29568298/trying-to-see-the-forest-through-the-trees-deciphering-the-nature-of-memory-immunity-to-mycobacterium-tuberculosis
#12
REVIEW
Ian M Orme, Marcela I Henao-Tamayo
The purpose of vaccination against tuberculosis and other diseases is to establish a heightened state of acquired specific resistance in which the memory immune response is capable of mediating an accelerated and magnified expression of protection to the pathogen when this is encountered at a later time. In the earliest studies in mice infected with Mycobacterium tuberculosis , memory immunity and the cells that express this were definable both in terms of kinetics of emergence, and soon thereafter by the levels of expression of markers including CD44, CD62L, and the chemokine receptor CCR7, allowing the identification of effector memory and central memory T cell subsets...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29549178/cxcl17-chemokine-dependent-mobilization-of-cxcr8-cd8-effector-memory-and-tissue-resident-memory-t-cells-in-the-vaginal-mucosa-is-associated-with-protection-against-genital-herpes
#13
Ruchi Srivastava, Marcela Hernández-Ruiz, Arif A Khan, Mona A Fouladi, Grace J Kim, Vincent T Ly, Taikun Yamada, Cynthia Lam, Sheilouise A B Sarain, Undariya Boldbaatar, Albert Zlotnik, Elmostafa Bahraoui, Lbachir BenMohamed
Circulating conventional memory CD8+ T cells (i.e., the CD8+ effector memory T [TEM ] cell and CD8+ central memory T [TCM ] cell subsets) and the noncirculating CD8+ tissue-resident memory T (TRM ) cell subset play a critical role in mucosal immunity. Mucosal chemokines, including the recently discovered CXCL17, are also important in mucosal immunity because they are homeostatically expressed in mucosal tissues. However, whether the CXCL17 chemokine contributes to the mobilization of memory CD8+ T cell subsets to access infected mucosal tissues remains to be elucidated...
March 16, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29545648/il-1%C3%AE-as-mucosal-vaccine-adjuvant-the-specific-induction-of-tissue-resident-memory-t-cells-improves-the-heterosubtypic-immunity-against-influenza-a-viruses
#14
D Lapuente, M Storcksdieck Genannt Bonsmann, A Maaske, V Stab, V Heinecke, K Watzstedt, R Heß, A M Westendorf, W Bayer, C Ehrhardt, M Tenbusch
A universal influenza vaccine must provide protection against antigenically divergent influenza viruses either through broadly neutralizing antibodies or cross-reactive T cells. Here, intranasal immunizations with recombinant adenoviral vectors (rAd) encoding hemagglutinin (HA) and nucleoprotein (NP) in combination with rAd-Interleukin-(IL)-1β or rAd-IL-18 were evaluated for their efficacy in BALB/c mice. Mucosal delivery of rAd-IL-1β enhanced HA-specific antibody responses including strain-specific neutralizing antibodies...
March 15, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29520279/human-langerhans-cells-with-pro-inflammatory-features-relocate-within-psoriasis-lesions
#15
REVIEW
Liv Eidsmo, Elisa Martini
Psoriasis is a common skin disease that presents with well-demarcated patches of inflammation. Recurrent disease in fixed areas of the skin indicates a localized disease memory that is preserved in resolved lesions. In line with such concept, the involvement of tissue-resident immune cells in psoriasis pathology is increasingly appreciated. Langerhans cells (LCs) are perfectly placed to steer resident T cells and local tissue responses in psoriasis. Here, we present an overview of the current knowledge of LCs in human psoriasis, including findings that highlight pro-inflammatory features of LCs in psoriasis lesions...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29518353/nanoparticle-fusion-protein-complexes-protect-against-mycobacterium-tuberculosis-infection
#16
Peter Hart, Alastair Copland, Gil Reynolds Diogo, Shane Harris, Ralf Spallek, Wulf Oehlmann, Mahavir Singh, Juan Basile, Martin Rottenberg, Matthew John Paul, Rajko Reljic
Tuberculosis (TB) is the leading cause of death from infectious disease, and the current vaccine, Bacillus Calmette-Guerin (BCG), is inadequate. Nanoparticles (NPs) are an emerging vaccine technology, with recent successes in oncology and infectious diseases. NPs have been exploited as antigen delivery systems and also for their adjuvantic properties. However, the mechanisms underlying their immunological activity remain obscure. Here, we developed a novel mucosal TB vaccine (Nano-FP1) based upon yellow carnauba wax NPs (YC-NPs), coated with a fusion protein consisting of three Mycobacterium tuberculosis (Mtb) antigens: Acr, Ag85B, and HBHA...
March 7, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29514949/the-tnf-superfamily-molecule-light-promotes-the-generation-of-circulating-and-lung-resident-memory-cd8-t-cells-following-an-acute-respiratory-virus-infection
#17
Pritesh Desai, Vikas Tahiliani, Tarun E Hutchinson, Farhad Dastmalchi, Jessica Stanfield, Georges Abboud, Paul G Thomas, Carl F Ware, Jianxun Song, Michael Croft, Shahram Salek-Ardakani
The transition of effector T cells or memory precursors into distinct long-lived memory T cell subsets is not well understood. Although many molecules made by APCs can contribute to clonal expansion and effector cell differentiation, it is not clear if clonal contraction and memory development is passive or active. Using respiratory virus infection, we found that CD8 T cells that cannot express the TNF family molecule lymphotoxin-like, exhibits i nducible expression, competes with HSV g lycoprotein D for herpes virus entry mediator, a receptor expressed by T lymphocytes (LIGHT) are unimpaired in their initial response and clonally expand to form effector cell pools...
March 7, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29514902/dynamics-of-tissue-specific-cd8-t-cell-responses-during-west-nile-virus-infection
#18
Renan Aguilar-Valenzuela, Jason Netland, Young-Jin Seo, Michael J Bevan, Arash Grakoui, Mehul S Suthar
The mouse model of West Nile virus, which is a leading cause of mosquito-borne encephalitis worldwide, has provided fundamental insights into the host and viral factors that regulate viral pathogenesis and infection outcome. In particular, CD8+ T cells are critical for controlling WNV replication and promoting protection against infection. Here, we present the characterization of a T cell receptor (TCR) transgenic mouse with specificity to the immunodominant epitope in the WNV NS4B protein (herein referred to as transgenic WNV-I mice)...
March 7, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29500823/brain-resident-memory-cd8-t-cells-induced-by-congenital-cmv-infection-prevent-brain-pathology-and-virus-reactivation
#19
Ilija Brizić, Božo Sušak, Maja Arapović, Peter C Huszthy, Lea Hiršl, Daria Kveštak, Vanda Juranić Lisnić, Mijo Golemac, Ester Pernjak Pugel, Jelena Tomac, Annette Oxenius, William J Britt, Jurica Arapović, Astrid Krmpotić, Stipan Jonjić
Congenital HCMV infection is a leading infectious cause of long-term neurodevelopmental sequelae. Infection of newborn mice with MCMV intraperitoneally is a well-established model of congenital HCMV infection, which best recapitulates the hematogenous route of virus spread to brain and subsequent pathology. Here we used this model to investigate the role, dynamics and phenotype of CD8+ T cells in the brain following infection of newborn mice. We show that CD8+ T cells infiltrate the brain and form a pool of tissue-resident memory T cells (TRM cells) that persist for lifetime...
March 3, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29491007/fucosyltransferase-induction-during-influenza-virus-infection-is-required-for-the-generation-of-functional-memory-cd4-t-cells
#20
Roberto Tinoco, Florent Carrette, Monique L Henriquez, Yu Fujita, Linda M Bradley
T cells mediating influenza viral control are instructed in lymphoid and nonlymphoid tissues to differentiate into memory T cells that confer protective immunity. The mechanisms by which influenza virus-specific memory CD4+ T cells arise have been attributed to changes in transcription factors, cytokines and cytokine receptors, and metabolic programming. The molecules involved in these biosynthetic pathways, including proteins and lipids, are modified to varying degrees of glycosylation, fucosylation, sialation, and sulfation, which can alter their function...
February 28, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
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