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https://www.readbyqxmd.com/read/27903738/tgf-%C3%AE-controls-the-formation-of-kidney-resident-t-cells-via-promoting-effector-t-cell-extravasation
#1
Chaoyu Ma, Shruti Mishra, Erika L Demel, Yong Liu, Nu Zhang
Tissue-resident memory T (TRM) cells, a population of noncirculating memory T cells, are one of the essential components of immunological memory in both mouse and human. Although CD69(+)CD103(+) TRM cells represent a major TRM cell population in barrier tissues including the mucosal surface and the skin, CD69(+)CD103(-) TRM cells dominate most nonbarrier tissues, such as the kidney. TGF-β is required for the differentiation of CD69(+)CD103(+) TRM cells in barrier tissues. However, the developmental control of CD69(+)CD103(-) TRM cells in nonbarrier tissues remains largely unknown and the involvement of TGF-β signaling is less clear...
November 30, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27902245/streptomyces-luteus-sp-nov-a-novel-actinomycete-isolated-from-loulan-soil-of-xinjiang-china
#2
Xiaoxia Luo, Kai Liang, Yang Wang, Chuanxing Wan, Lili Zhang
A Streptomyces strain, designated TRM 45540T, was isolated from the soil of Loulan area(89°22'22″E, 40°29'55″N), Xinjiang Province, north-west China and was characterized taxonomically by using a polyphasic study. Phylogenetic analysis of the strain from 16S rRNA sequence revealed the strain TRM 45540 had 99.87% similarity with the type strain Streptomyces mutabilis NRRL12800T (GenBank accession number. AB184156). The strain was aerobic, gram-staining-positive, with an optimum NaCl concentration for growth of 5% (w/v)...
November 1, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27899444/antigen-dependent-competition-shapes-the-local-repertoire-of-tissue-resident-memory-cd8-t-cells
#3
Andreas Muschaweckh, Veit R Buchholz, Anne Fellenzer, Christian Hessel, Paul-Albert König, Sha Tao, Ronny Tao, Mathias Heikenwälder, Dirk H Busch, Thomas Korn, Wolfgang Kastenmüller, Ingo Drexler, Georg Gasteiger
Tissue-resident memory CD8(+) T cells (TRM) constitute a major component of the immune-surveillance system in nonlymphoid organs. Local, noncognate factors are both necessary and sufficient to support the programming of TRM cell fate in tissue-infiltrating T cells. Recent evidence suggests that TCR signals received in infected nonlymphoid tissues additionally contribute to TRM cell formation. Here, we asked how antigen-dependent pathways influence the generation of skin-resident memory T cells that arise from a polyclonal repertoire of cells induced by infection with an antigenically complex virus and recombinant vaccine vector...
November 29, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27879332/mucosal-bcg-vaccination-induces-protective-lung-resident-memory-t-cell-populations-against-tuberculosis
#4
Carolina Perdomo, Ulrike Zedler, Anja A Kühl, Laura Lozza, Philippe Saikali, Leif E Sander, Alexis Vogelzang, Stefan H E Kaufmann, Andreas Kupz
: Mycobacterium bovis Bacille Calmette-Guérin (BCG) is the only licensed vaccine against tuberculosis (TB), yet its moderate efficacy against pulmonary TB calls for improved vaccination strategies. Mucosal BCG vaccination generates superior protection against TB in animal models; however, the mechanisms of protection remain elusive. Tissue-resident memory T (TRM) cells have been implicated in protective immune responses against viral infections, but the role of TRM cells following mycobacterial infection is unknown...
November 22, 2016: MBio
https://www.readbyqxmd.com/read/27876574/the-emerging-role-of-ecm-crosslinking-in-t-cell-mobility-as-a-hallmark-of-immunosenescence-in-humans
#5
REVIEW
Jean-Francois Moreau, Thomas Pradeu, Andrea GRignolio, Christine Nardini, Filippo Castiglione, Paolo Tieri, Miriam Capri, Stefano Salvioli, Jean-Luc Taupin, Paolo Garagnani, Claudio Franceschi
Immunosenescence is thought to result from cellular aging and to reflect exposure to environmental stressors and antigens, including cytomegalovirus (CMV). However, not all of the features of immunosenescence are consistent with this view, and this has led to the emergence of the sister theory of "inflammaging". The recently discovered diffuse tissue distribution of resident memory T cells (TRM) which don't recirculate, calls these theories into question. These cells account for most T cells residing in barrier epithelia which sit in and travel through the extracellular matrix (ECM)...
November 19, 2016: Ageing Research Reviews
https://www.readbyqxmd.com/read/27873334/rapid-allergen-induced-interleukin-17-and-interferon-%C3%AE-secretion-by-skin-resident-memory-cd8-t-cells
#6
Jonas D Schmidt, Malin G Ahlström, Jeanne D Johansen, Beatrice Dyring-Andersen, Christina Agerbeck, Morten M Nielsen, Steen S Poulsen, Anders Woetmann, Niels Ødum, Allan R Thomsen, Carsten Geisler, Charlotte M Bonefeld
BACKGROUND: Skin-resident memory T (TRM ) cells are associated with immunological memory in the skin. Whether immunological memory responses to allergens in the skin are solely localized to previously allergen-exposed sites or are present globally in the skin is not clear. Furthermore, the mechanisms whereby TRM cells induce rapid recall responses need further investigation. OBJECTIVES: To study whether contact allergens induce local and/or global memory, and to determine the mechanisms involved in memory responses in the skin...
November 22, 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/27872737/immunity-to-infections-after-haploidentical-hematopoietic-stem-cell-transplantation
#7
REVIEW
Franco Aversa, Lucia Prezioso, Ilenia Manfra, Federica Galaverna, Angelica Spolzino, Alessandro Monti
The advantage of using a Human Leukocyte Antigen (HLA)-mismatched related donor is that almost every patient who does not have an HLA-identical donor or who urgently needs hematopoietic stem cell transplantation (HSCT) has at least one family member with whom shares one haplotype (haploidentical) and who is promptly available as a donor. The major challenge of haplo-HSCT is intense bi-directional alloreactivity leading to high incidences of graft rejection and graft-versus-host disease (GVHD). Advances in graft processing and pharmacologic prophylaxis of GVHD have reduced these risks and have made haplo-HSCT a viable alternative for patients lacking a matched donor...
2016: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/27865124/the-killer-cell-story-in-recurrent-miscarriage-association-between-activated-peripheral-lymphocytes-and-uterine-natural-killer-cells
#8
R J Kuon, K Vomstein, M Weber, F Müller, C Seitz, S Wallwiener, T Strowitzki, E Schleussner, U R Markert, V Daniel, B Toth
Peripheral and uterine NK cells (pNK, uNK) can be distinguished according to their receptor expression. Recent studies indicate an association of elevated pNK and uNK with recurrent miscarriage (RM). This study aimed to analyze pNK and uNK in patients with RM and healthy controls. Out of n=590 RM patients screened according to a standard diagnostic protocol, n=268 couples with ≥3 consecutive RM were identified. Subgroups consisted of n=151 primary RM (pRM), n=85 secondary RM (sRM), n=32 tertiary RM (tRM) and n=42 healthy controls...
November 6, 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/27864604/the-long-term-outcome-of-reduced-intensity-allogeneic-stem-cell-transplantation-from-a-matched-related-or-unrelated-donor-or-haploidentical-family-donor-in-patients-with-leukemia-a-retrospective-analysis-of-data-from-the-china-ric-cooperative-group
#9
Chang-Lin Yu, Zheng-Dong, Zhen-Hua Qiao, Jian-Min Wang, Huang-He, Ying-Min Liang, De-Pei Wu, Bao-An Chen, Bai-Hai, Bao-Fu Shi, Wan-Jun Sun, Jun-Xiao Qiao, Mei Guo, Jian-Hui Qiao, Qi-Yun Sun, Kai-Xun Hu, Ya-Jing Huang, Hong-Li Zuo, Xiao-Jun Huang, Hui-Sheng Ai
This study compared 6-year follow-up data from patients undergoing reduced-intensity conditioning (RIC) transplantation with an HLA-matched related donor (MRD), an HLA-matched unrelated donor (MUD), or an HLA-haploidentical donor (HID) for leukemia. Four hundred and twenty-seven patients from the China RIC Cooperative Group were enrolled, including 301 in the MRD, 79 in the HID, and 47 in the MUD groups. The conditioning regimen involved fludarabine combined with anti-lymphocyte globulin and cyclophosphamide...
November 18, 2016: Annals of Hematology
https://www.readbyqxmd.com/read/27861815/intestinal-helminth-infection-induces-highly-functional-resident-memory-cd4-t-cells-in-mice
#10
Svenja Steinfelder, Sebastian Rausch, Dörte Michael, Anja A Kühl, Susanne Hartmann
Immunity to intestinal nematodes requires CD4⁺ Th2-cell responses, including IL-4 and IL-13 production. Chronic infection with intestinal nematodes leads to downregulation of these responses, and few functional T helper (Th) 2 cells are detected in secondary lymphoid organs in the chronic phase or after abrogation of infection. Here, we show with a natural murine infection with Heligmosomoides polygyrus that highly functional memory Th2 cells persist in the lamina propria and in addition in the peritoneal cavity (PC) after abrogation of infection...
November 10, 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27861803/%C3%AE-4-%C3%AE-1-integrin-promotes-accumulation-of-tissue-resident-memory-cd8-t-cells-in-salivary-glands
#11
Sandra Woyciechowski, Maike Hofmann, Hanspeter Pircher
The salivary glands (SGs) of virus-immune mice contain substantial numbers of tissue-resident memory CD8(+) T cells (TRM cells) that can provide immunity to local infections. Integrins regulate entry of activated T cells into non-lymphoid tissues but the molecules that mediate migration of virus-specific CD8(+) T cells to the SGs have not yet been defined. Here, we found that polyinosinic-polycytidylic acid (poly(I:C)) strongly promoted the accumulation of P14 TCR-transgenic CD8(+) TRM cells in SGs in an α4 β1 integrin-dependent manner...
November 11, 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27842860/-haploidentical-hematopoietic-stem-cell-transplantation-guidelines-from-the-francophone-society-of-marrow-transplantation-and-cellular-therapy-sfgm-tc
#12
Stéphanie Nguyen, Yves Chalandon, Claude Lemarie, Sophie Simon, Dominique Masson, Nathalie Dhedin, Felipe Suarez, Barbara Renaud, Amandine Charbonnier, Nabil Yafour, Sylvie François, Rémy Duléry, Didier Blaise, Ibrahim Yakoub-Agha, Marie-Thérèse Rubio
Haploidentical hematopoietic stem cell transplantation (HSCT) is being increasingly used due to improvement of the transplantation procedures allowing a reduction of graft-versus-host-disease (GVHD) and of transplant-related mortality (TRM). Such improvements have been particularly observed after administration of T-replete HSCT graft associated to an in vivo T cell depletion by the administration of high-doses of cyclophosphamide (HD-Cy) after transplantation. Here, we have analyzed the results of haplo-identical T replete HSC transplants, in particular, when performed with post-transplant HD-Cy in order to provide recommendations for the clinical practice...
November 2016: Bulletin du Cancer
https://www.readbyqxmd.com/read/27827367/cd301b-dendritic-cells-stimulate-tissue-resident-memory-cd8-t-cells-to-protect-against-genital-hsv-2
#13
Haina Shin, Yosuke Kumamoto, Smita Gopinath, Akiko Iwasaki
Tissue-resident memory CD8+ T (CD8 TRM) cells are an essential component of protective immune responses at barrier tissues, including the female genital tract. However, the mechanisms that lead to the initiation of CD8 TRM-mediated protective immunity after viral infection are unclear. Here we report that CD8 TRM cells established by 'prime and pull' method confer protection against genital HSV-2 infection, and that IFN-γ produced by CD8 TRM cells is required for this protection. Furthermore, we find that CD8 TRM-cell restimulation depends on a population of CD301b(+) antigen-presenting cells (APC) in the lamina propria...
November 9, 2016: Nature Communications
https://www.readbyqxmd.com/read/27826061/risk-factors-and-outcomes-of-infections-by-multidrug-resistant-gram-negative-bacteria-in-patients-undergoing-hematopoietic-stem-cell-transplantation
#14
Francesca Patriarca, Chiara Cigana, Dozzo Massimo, Davide Lazzarotto, Antonella Geromin, Miriam Isola, Marta Lisa Battista, Marta Medeot, Michela Cerno, Alessandra Sperotto, Anna Candoni, Massimo Crapis, Assunta Sartor, Claudio Scarparo, Matteo Bassetti, Renato Fanin
The objective of this study was to determine risk factors and outcomes of infections by multidrug-resistant gram-negative (MDR GN) bacteria in 241 recipients of hematopoietic stem cell transplantation (HSCT). The cumulative incidence of infections was 10.5% (95% CI, 12.0% to 25.8%), with 57% of infections occurring during the period of severe neutropenia (neutrophil count < .1 × 10(6)/L). In multivariate analysis, allogeneic transplant and colonization with MDR GN bacteria at admission to the transplant unit were significantly associated with an increased risk of infection...
November 4, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27815325/specific-niches-for-lung-resident-memory-cd8-t-cells-at-the-site-of-tissue-regeneration-enable-cd69-independent-maintenance
#15
Shiki Takamura, Hideki Yagi, Yoshiyuki Hakata, Chihiro Motozono, Sean R McMaster, Tomoko Masumoto, Makoto Fujisawa, Tomomi Chikaishi, Junko Komeda, Jun Itoh, Miki Umemura, Ami Kyusai, Michio Tomura, Toshinori Nakayama, David L Woodland, Jacob E Kohlmeier, Masaaki Miyazawa
CD8(+) tissue-resident memory T cells (TRM cells) reside permanently in nonlymphoid tissues and provide a first line of protection against invading pathogens. However, the precise localization of CD8(+) TRM cells in the lung, which physiologically consists of a markedly scant interstitium compared with other mucosa, remains unclear. In this study, we show that lung CD8(+) TRM cells localize predominantly in specific niches created at the site of regeneration after tissue injury, whereas peripheral tissue-circulating CD8(+) effector memory T cells (TEM cells) are widely but sparsely distributed in unaffected areas...
November 4, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27809289/pretransplant-levels-of-crp-and-interleukin-6-family-cytokines-effects-on-outcome-after-allogeneic-stem-cell-transplantation
#16
Tor Henrik Tvedt, Stein Atle Lie, Håkon Reikvam, Kristin Paulsen Rye, Roald Lindås, Tobias Gedde-Dahl, Aymen Bushra Ahmed, Øystein Bruserud
Several pretransplant factors, including CRP (C-reactive protein) levels, reflect the risk of complications after allogeneic stem cell transplantation. IL-6 induces CRP increase, and we therefore investigated the effects of pretransplant IL-6, soluble IL-6 receptors, IL-6 family cytokines and CRP serum levels on outcome for 100 consecutive allotransplant recipients. All patients had related donors, none had active infections and 99 patients were in complete remission before conditioning. The incidence of acute graft versus host disease (aGVHD) requiring treatment was 40%, survival at Day +100 82%, and overall survival 48%...
November 1, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27807191/mast-cells-limit-the-exacerbation-of-chronic-allergic-contact-dermatitis-in-response-to-repeated-allergen-exposure
#17
Vladimir-Andrey Gimenez-Rivera, Frank Siebenhaar, Carolin Zimmermann, Hanna Siiskonen, Martin Metz, Marcus Maurer
Allergic contact dermatitis is a chronic T cell-driven inflammatory skin disease that is caused by repeated exposure to contact allergens. Based on murine studies of acute contact hypersensitivity, mast cells (MCs) are believed to play a role in its pathogenesis. The role of MCs in chronic allergic contact dermatitis has not been investigated, in part because of the lack of murine models for chronic contact hypersensitivity. We developed and used a chronic contact hypersensitivity model in wild-type and MC-deficient mice and assessed skin inflammatory responses to identify and characterize the role of MCs in chronic allergic contact dermatitis...
November 2, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27804207/implications-of-resident-memory-t-cells-for-transplantation
#18
Lalit K Beura, Pamela C Rosato, David Masopust
Recent studies have established resident memory T cells (TRM ) as the dominant memory lymphocyte population surveying most non-lymphoid tissues. Unlike other memory T cell lineages, TRM  do not recirculate through blood and are permanently confined to their tissue of residence. TRM orchestrate local immune responses and have been shown to accelerate local pathogen control in many experimental infection models. Here we briefly summarize recent advances in TRM  differentiation, maintenance and their protective function...
November 2, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27802434/outcome-comparison-of-allogeneic-versus-autologous-stem-cell-transplantation-in-transformed-low-grade-lymphoid-malignancies-a-systematic-review-and-pooled-analysis-of-comparative-studies
#19
Seongseok Yun, Nicole D Vincelette, Ivo Abraham, Soham Puvvada, Faiz Anwer
BACKGROUND: Some patients with low-grade lymphoid malignancies develop transformed disease, requiring stem cell transplantation (SCT). SCT outcomes in transformed low-grade lymphoid malignancies may differ from those of nontransformed disease or other aggressive non-Hodgkin lymphomas. We conducted a pooled analysis of the clinical outcomes of allogeneic versus high-dose therapy (HDT) with autologous SCT in adult patients with transformed low-grade lymphoid malignancies. METHODS: A PubMed, EMBASE, and Cochrane search yielded 4 comparative studies reporting allogeneic versus HDT with autologous SCT outcomes in adults (age ≥18) with transformed low-grade lymphoid malignancies, including follicular, chronic/small lymphocytic, and marginal zone lymphoma...
2016: Acta Haematologica
https://www.readbyqxmd.com/read/27788759/matched-unrelated-donor-transplants-state-of-the-art-in-the-21st-century
#20
REVIEW
Syed Y Altaf, Jane F Apperley, Eduardo Olavarria
Hematopoietic stem cell transplantation (HSCT) is the therapy of choice in many hematological malignant and non-malignant diseases by using human leukocyte antigen (HLA)-matched siblings as stem cell source but only one third of the patients will have HLA-matched siblings. Hence, physicians rely on the availability of matched unrelated donors (URD). The possibility of finding a matched URD is now more than 70% due to continuous expansion of URD registries around the world. The use of URD in adult patients is steadily increasing and in the last 8 years has superseded the numbers of matched sibling donor transplants and has become the most commonly used stem cell source...
October 2016: Seminars in Hematology
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