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https://www.readbyqxmd.com/read/28108046/rules-of-performance-in-the-nursing-home-a-grounded-theory-of-nurse-cna-communication
#1
Connie Madden, Margaret Clayton, Heather Canary, Gail Towsley, Kristin Cloyes, Dale Lund
This study offers an initial theoretical understanding of nurse-CNA communication processes from the perspectives of nurses and CNAs who are providing direct care to residents in nursing homes. A grounded theory approach provided an understanding of nurse-CNA communication process within the complexities of the nursing home setting. Four themes (maintaining information flow, following procedure, fostering collegiality, and showing respect) describe the "rules of performance" that intertwine in nuanced relationships to guide nurse-CNA communication processes...
January 17, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/28104345/polybrominated-diphenyl-ethers-residence-time-in-soils-receiving-biosolids-application
#2
Natasha A Andrade, Laura L McConnell, Marya O Anderson, Alba Torrents, Mark Ramirez
Polybrominated diphenyl ethers (PBDEs) may enter the environment because of accumulation in biosolids followed by application to agricultural lands. No published dissipation studies are available for PBDEs in agricultural soils after biosolids application. Therefore, we conducted a 3-year study to examine the fate of PBDEs in a small-scale 0.24-ha continuously cropped field after a single biosolids application at 72.3 wet tons/ha and determined dissipation half-lives for BDE-47+BDE-99 and BDE-209. In addition, we conducted a large-scale survey of soils from 26 mostly pasture fields at 10 farms with detailed information on timing and rate of biosolids applications...
January 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28102960/nine-degrees-of-freedom-flexmap-for-a-cone-beam-computed-tomography-imaging-device-with-independently-movable-source-and-detector
#3
Peter Keuschnigg, Daniel Kellner, Karl Fritscher, Andrea Zechner, Ulrich Mayer, Philipp Huber, Felix Sedlmayer, Heinz Deutschmann, Philipp Steininger
PURPOSE: Couch-mounted cone-beam computed tomography (CBCT) imaging devices with independently rotatable x-ray source and flat-panel detector arms for acquisitions of arbitrary regions of interest (ROI) have recently been introduced in image-guided radiotherapy (IGRT). This work analyzes mechanical limitations and gravity-induced effects influencing the geometric accuracy of images acquired with arbitrary angular constellations of source and detector in nonisocentric trajectories, which is considered essential for IGRT...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28099267/measurement-error-correction-for-predicted-spatiotemporal-air-pollution-exposures
#4
Joshua P Keller, Howard H Chang, Matthew J Strickland, Adam A Szpiro
BACKGROUND: Air pollution cohort studies are frequently analyzed in two stages, first modeling exposure then using predicted exposures to estimate health effects in a second regression model. The difference between predicted and unobserved true exposures introduces a form of measurement error in the second stage health model. Recent methods for spatial data correct for measurement error with a bootstrap and by requiring the study design ensure spatial compatibility, i.e., monitor and subject locations are drawn from the same spatial distribution...
January 17, 2017: Epidemiology
https://www.readbyqxmd.com/read/28097478/study-of-the-influence-of-formulation-variables-in-bioadhesive-emulgels-using-response-surface-methodology
#5
Ana Ochoa-Andrade, M Emma Parente, Álvaro Jimenez-Kairuz, Lucía Boinbaser, Annibal Torregrosa
The aim of the present work was to study the main formulation variables that influence attributes of bioadhesive emulgels based on a combination of polymers, using response surface methodology (RSM). Bioadhesive products continue to gain attention in topical cutaneous administration as they allow long residence times on the application site, which is important when a long dermal action and a reduced product administration frequency are desired. A Box-Behnken design of experiments (DoE) was introduced to study the effect of formulation variables on quality attributes of the emulgels...
January 17, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28096249/natural-language-processing-to-extract-symptoms-of-severe-mental-illness-from-clinical-text-the-clinical-record-interactive-search-comprehensive-data-extraction-cris-code-project
#6
Richard G Jackson, Rashmi Patel, Nishamali Jayatilleke, Anna Kolliakou, Michael Ball, Genevieve Gorrell, Angus Roberts, Richard J Dobson, Robert Stewart
OBJECTIVES: We sought to use natural language processing to develop a suite of language models to capture key symptoms of severe mental illness (SMI) from clinical text, to facilitate the secondary use of mental healthcare data in research. DESIGN: Development and validation of information extraction applications for ascertaining symptoms of SMI in routine mental health records using the Clinical Record Interactive Search (CRIS) data resource; description of their distribution in a corpus of discharge summaries...
January 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28093648/predicting-cell-viability-within-tissue-scaffolds-under-equiaxial-strain-multi-scale-finite-element-model-of-collagen-cardiomyocytes-constructs
#7
Mostafa Elsaadany, Karen Chang Yan, Eda Yildirim-Ayan
Successful tissue engineering and regenerative therapy necessitate having extensive knowledge about mechanical milieu in engineered tissues and the resident cells. In this study, we have merged two powerful analysis tools, namely finite element analysis and stochastic analysis, to understand the mechanical strain within the tissue scaffold and residing cells and to predict the cell viability upon applying mechanical strains. A continuum-based multi-length scale finite element model (FEM) was created to simulate the physiologically relevant equiaxial strain exposure on cell-embedded tissue scaffold and to calculate strain transferred to the tissue scaffold (macro-scale) and residing cells (micro-scale) upon various equiaxial strains...
January 16, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28093047/3d-cell-printing-of-large-volume-tissues-application-to-ear-regeneration
#8
Jung-Seob Lee, Byung Soo Kim, Dong Hwan Seo, Jeong Hun Park, Dong-Woo Cho
The three-dimensional (3D) printing of large-volume cells, printed in a clinically relevant size, is one of the most important challenges in the field of tissue engineering. However, few studies have reported the fabrication of large-volume cell-printed constructs (LCCs). To create LCCs, appropriate fabrication conditions should be established: factors involved include fabrication time, residence time, and temperature control of the cell-laden hydrogel in the syringe to ensure high cell viability and functionality...
January 17, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28087927/genome-wide-approaches-to-defining-macrophage-identity-and-function
#9
Gregory J Fonseca, Jason S Seidman, Christopher K Glass
Macrophages play essential roles in the response to injury and infection and contribute to the development and/or homeostasis of the various tissues they reside in. Conversely, macrophages also influence the pathogenesis of metabolic, neurodegenerative, and neoplastic diseases. Mechanisms that contribute to the phenotypic diversity of macrophages in health and disease remain poorly understood. Here we review the recent application of genome-wide approaches to characterize the transcriptomes and epigenetic landscapes of tissue-resident macrophages...
October 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/28086864/direct-detection-of-falciparum-and-non-falciparum-malaria-dna-from-a-drop-of-blood-with-high-sensitivity-by-the-dried-lamp-system
#10
Kyoko Hayashida, Kiichi Kajino, Humphrey Simukoko, Martin Simuunza, Joseph Ndebe, Amos Chota, Boniface Namangala, Chihiro Sugimoto
BACKGROUND: Because of the low sensitivity of conventional rapid diagnostic tests (RDTs) for malaria infections, the actual prevalence of the diseases, especially those caused by non-Plasmodium falciparum (non-Pf) species, in asymptomatic populations remain less defined in countries lacking in well-equipped facilities for accurate diagnoses. Our direct blood dry LAMP system (CZC-LAMP) was applied to the diagnosis of malaria as simple, rapid and highly sensitive method as an alternative for conventional RDTs in malaria endemic areas where laboratory resources are limited...
January 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28080056/metadynamics-simulations-distinguish-short-and-long-residence-time-inhibitors-of-cyclin-dependent-kinase-8
#11
Donatella Callegari, Alessio Lodola, Daniele Pala, Silvia Rivara, Marco Mor, Andrea Rizzi, Anna Maria Capelli
The duration of drug efficacy in vivo is a key aspect primarily addressed during the lead optimization phase of drug discovery. Hence, the availability of robust computational approaches that can predict the residence time of a compound at its target would accelerate candidate selection. Nowadays the theoretical prediction of this parameter is still very challenging. Starting from methods reported in the literature, we set up and validated a new metadynamics (META-D)-based protocol that was used to rank the experimental residence times of 10 arylpyrazole cyclin-dependent kinase 8 (CDK8) inhibitors for which target-bound X-ray structures are available...
January 12, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28079646/public-health-agency-accreditation-among-rural-local-health-departments-influencers-and-barriers
#12
Kate E Beatty, Paul Campbell Erwin, Ross C Brownson, Michael Meit, James Fey
OBJECTIVE: Health department accreditation is a crucial strategy for strengthening public health infrastructure. The purpose of this study was to investigate local health department (LHD) characteristics that are associated with accreditation-seeking behavior. This study sought to ascertain the effects of rurality on the likelihood of seeking accreditation through the Public Health Accreditation Board (PHAB). DESIGN: Cross-sectional study using secondary data from the 2013 National Association of County & City Health Officials (NACCHO) National Profile of Local Health Departments Study (Profile Study)...
January 11, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28079598/interobserver-agreement-in-endometrial-carcinoma-histotype-diagnosis-varies-depending-on-the-cancer-genome-atlas-tcga-based-molecular-subgroup
#13
Lien N Hoang, Mary A Kinloch, Joyce M Leo, Katherine Grondin, Cheng-Han Lee, Carol Ewanowich, Martin Köbel, Angela Cheng, Aline Talhouk, Melissa McConechy, David G Huntsman, Jessica N McAlpine, Robert A Soslow, C Blake Gilks
The Cancer Genome Atlas recently identified a genomic-based molecular classification of endometrial carcinomas, with 4 molecular categories: (1) ultramutated (polymerase epsilon [POLE] mutated), (2) hypermutated (microsatellite instability), (3) copy number abnormalities-low, and (4) copy number abnormalities-high. Two studies have since proposed models to classify endometrial carcinomas into 4 molecular subgroups, modeled after The Cancer Genome Atlas, using simplified and more clinically applicable surrogate methodologies...
February 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28076861/potential-applications-of-smart-multifunctional-wearable-materials-to-gerontology
#14
David G Armstrong, Bijan Najafi, Mohsen Shahinpoor
Smart multifunctional materials can play a constructive role in addressing some very important aging-related issues. Aging affects the ability of older adults to continue to live safely and economically in their own residences for as long as possible. Thus, there will be a greater need for preventive, acute, rehabilitative, and long-term health care services for older adults as well as a need for tools to enable them to function independently during daily activities. The objective of this paper is, thus, to present a comprehensive review of some potential smart materials and their areas of applications to gerontology...
January 12, 2017: Gerontology
https://www.readbyqxmd.com/read/28075354/the-state-of-the-art-of-lethal-oviposition-trap-based-mass-interventions-for-arboviral-control
#15
Brian J Johnson, Scott A Ritchie, Dina M Fonseca
The intensifying expansion of arboviruses highlights the need for effective invasive Aedes control. While mass-trapping interventions have long been discredited as inefficient compared to insecticide applications, increasing levels of insecticide resistance, and the development of simple affordable traps that target and kill gravid female mosquitoes, show great promise. We summarize the methodologies and outcomes of recent lethal oviposition trap-based mass interventions for suppression of urban Aedes and their associated diseases...
January 8, 2017: Insects
https://www.readbyqxmd.com/read/28069025/interaction-of-biomedical-nanoparticles-with-the-pulmonary-immune-system
#16
REVIEW
Fabian Blank, Kleanthis Fytianos, Emilie Seydoux, Laura Rodriguez-Lorenzo, Alke Petri-Fink, Christophe von Garnier, Barbara Rothen-Rutishauser
Engineered nanoparticles (NPs) offer site-specific delivery, deposition and cellular uptake due to their unique physicochemical properties and were shown to modulate immune responses. The respiratory tract with its vast surface area is an attractive target organ for innovative immunomodulatory therapeutic applications by pulmonary administration of such NPs, enabling interactions with resident antigen-presenting cells (APCs), such as dendritic cells and macrophages. Depending on the respiratory tract compartment, e...
January 9, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28068988/disability-support-and-long-term-social-care-of-an-elderly-spanish-population-2008-2009-an-epidemiologic-analysis
#17
J Almazán-Isla, M Comín-Comín, E Alcalde-Cabero, C Ruiz, E Franco, R Magallón, J Damián, J de Pedro-Cuesta, L A Larrosa-Montañes
BACKGROUND: Though poorly known, relationships between disability, need of help (dependency) and use of social services are crucial aspects of public health. The objective of this study was to describe the links between disability, officially assessed dependency, and social service use by an industrial population, and identify areas of inequity. METHODS: We took advantage of a door-to-door survey conducted in the Cinco Villas district, Spain, in 2008-2009, which provided data on disability, morbidity, and service use among 1216 residents aged ≥50 years, and officially assessed dependency under the 2006 Dependency Act (OAD)...
January 9, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28067461/phagocytosis-and-immune-response-studies-of-macrophage-nanodiamond-interactions-in-vitro-and-in-vivo
#18
K-J Huang, C-Y Lee, Y-C Lin, C-Y Lin, E Perevedentseva, S-F Hung, C-L Cheng
The applications of nanodiamond as drug delivery and bio-imaging can require the relinquishing ND-drug conjugate via blood flow, where interaction with immune cells may occur. In this work, we investigated the ND penetration in macrophage and the immune response using the tissue-resident murine macrophages (RAW 264.7). Confocal fluorescence imaging, immunofluorescence analysis of nuclear translocation of interferon regulatory factor IRF-3 and transcriptional factor NF-κΒ, analysis of pro-inflammatory cytokines production IL-1β, IL-6 IL-10 with a reverse transcription-polymerase chain reaction technique were applied...
January 9, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28065277/dynamic-intravital-imaging-of-cell-cell-interactions-in-the-lymph-node
#19
REVIEW
Jens V Stein, Santiago F Gonzalez
In the last decade, the application of 2-photon intravital microscopy as a tool to study cell interactions in different areas of the immune system has offered an unprecedented opportunity to understand the complexity of cell behavior in relation to immune functions. In this review we describe the latest advances in the field of live imaging in the lymph nodes, grouping the different cell populations in 2 compartments according to their motility: the sessile compartment, which is formed by resident cells of stromal origin, macrophages, and resident dendritic cells, and the motile compartment, which is mainly formed by T and B lymphocytes...
January 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28062073/sludge-accumulation-and-distribution-impact-the-hydraulic-performance-in-waste-stabilisation-ponds
#20
Liah X Coggins, Marco Ghisalberti, Anas Ghadouani
Waste stabilisation ponds (WSPs) are used worldwide for wastewater treatment, and throughout their operation require periodic sludge surveys. Sludge accumulation in WSPs can impact performance by reducing the effective volume of the pond, and altering the pond hydraulics and wastewater treatment efficiency. Traditionally, sludge heights, and thus sludge volume, have been measured using low-resolution and labour intensive methods such as 'sludge judge' and the 'white towel test'. A sonar device, a readily available technology, fitted to a remotely operated vehicle (ROV) was shown to improve the spatial resolution and accuracy of sludge height measurements, as well as reduce labour and safety requirements...
November 9, 2016: Water Research
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