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https://www.readbyqxmd.com/read/29340702/risk-and-protective-factors-for-depressive-symptoms-among-african-american-men-an-application-of-the-stress-process-model
#1
Mathew D Gayman, Ben Lennox Kail, Amy Spring, George R Greenidge
Objectives: This study employs the stress process model (SPM) to identify risk/protective factors for mental health among adult African American men. Method: Using a community-based sample of Miami, FL residents linked to neighborhood Census data, this study identifies risk/protective factors for depressive symptomatology using a sample of 248 adult African American men. Results: The stress process variables independently associated with depressive symptoms were family support, mastery, self-esteem, chronic stressors, and daily discrimination...
January 11, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/29340405/modulating-interactions-between-ligand-coated-nanoparticles-and-phase-separated-lipid-bilayers-by-varying-the-ligand-density-and-the-surface-charge
#2
Xiaojie Chen, D Peter Tieleman, Qing Liang
The interactions between nanoparticles and lipid bilayers are critical in applications of nanoparticles in nanomedicine, cell imaging, toxicology, and elsewhere. Here, we investigate the interactions between nanoparticles coated with neutral and/or charged ligands and phase-separated lipid bilayers using coarse-grained molecular dynamics simulation. Both penetration and adsorption processes as well as the final distribution of the nanoparticles can be readily modulated by varying the ligand density and the surface charge of the nanoparticles...
January 17, 2018: Nanoscale
https://www.readbyqxmd.com/read/29339249/semifluorinated-alkane-based-systems-for-enhanced-corneal-penetration-of-poorly-soluble-drugs
#3
Priyanka Agarwal, Dieter Scherer, Bernhard Günther, Ilva D Rupenthal
Semifluorinated alkanes (SFAs) are amphiphilic liquids that can dissolve hydrophobic drugs to form clear solutions. This study evaluated the potential of two SFAs to act as vehicle for topical ocular drug delivery. After confirming ocular safety, an ex vivo corneal penetration model was developed to determine drug distribution and corneal bioavailability. Hydrophobic dye distribution in the different corneal layers was visualised under a confocal microscope. Corneal bioavailability of cyclosporine A (CsA) dissolved in perfluorobutylpentane (F4H5) or perfluorohexyloctane (F6H8) was compared to commercially available CsA ophthalmic emulsions, Restasis® and Ikervis®...
January 12, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29338206/application-of-ptr-ms-and-33s-isotope-labelling-for-monitoring-sulfur-processes-in-livestock-waste
#4
Frederik Rask Dalby, Michael Jørgen Hansen, Anders Feilberg
Reduced sulfur compounds emitted from livestock production cause odor nuisance for local residents. The microbial processes responsible for this are not well described in swine manure and a method for monitoring the biological processes is necessary to develop strategic abatement technologies. In this study, Proton-Transfer-Reaction Mass Spectrometry and isotope labelled sulfate was combined and applied to elucidate the sulfur processes in swine manure with high time resolution. We successfully monitored reduction of isotope 33S labelled sulfate into corresponding 33S hydrogen sulfide and that some of the 33S hydrogen sulfide was further methylated into 33S methanethiol...
January 17, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29338190/cancer-cell-membrane-biomimetic-nanoprobes-with-two-photon-excitation-and-near-infrared-emission-for-intravital-tumor-fluorescence-imaging
#5
Yanlin Lv, Ming Liu, Yong Zhang, Xuefei Wang, Fan Zhang, Feng Li, Weier Bao, Jie Wang, Yuanlin Zhang, Wei Wei, Guanghui Ma, Liancheng Zhao, Zhiyuan Tian
Biomimetic fluorescent nanoprobes capable of emitting near-infrared (NIR) fluorescence (λmax ~720 nm) upon excitation of 800-nm light were developed. The key conjugated polymer enabled two-photon absorption (TPA) and Fӧrster resonance energy transfer (FRET) processes within the nanoprobes, which imparted the nanoprobes with ideal NIR-incoming-NIR-outgoing fluorescence features. The cancer cell membrane (CM) coating endowed these nanoprobes with perfect biocompatibility and highly specific targeting ability to homologous tumors...
January 16, 2018: ACS Nano
https://www.readbyqxmd.com/read/29337535/anion-mediated-photophysical-behavior-in-a-c60-fullerene-3-rotaxane-shuttle
#6
Timothy A Barendt, Ilija Rašović, Maria A Lebedeva, George A Farrow, Alexander Auty, Dimitri Chekulaev, Igor V Sazanovich, Julia A Weinstein, Kyriakos Porfyrakis, Paul D Beer
By addressing the challenge of controlling molecular motion, mechanically interlocked molecular machines are primed for a variety of applications in the field of nanotechnology. Specifically, the designed manipulation of communication pathways between electron donor and acceptor moieties that are strategically integrated into dynamic photoactive rotaxanes and catenanes may lead to efficient artificial photosynthetic devices. In this pursuit, a novel [3]rotaxane molecular shuttle consisting of a four station bis-naphthalene diimide (NDI) and central C60 fullerene bis-triazolium axle component and two mechanically bonded ferrocenyl functionalized -isophthalamide anion binding site-containing macrocycles is constructed using an anion template synthetic methodology...
January 16, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29337170/virtual-cerebral-aneurysm-clipping-with-real-time-haptic-force-feedback-in-neurosurgical-education
#7
Matthias Gmeiner, Johannes Dirnberger, Wolfgang Fenz, Maria Gollwitzer, Gabriele Wurm, Johannes Trenkler, Andreas Gruber
OBJECTIVE: Realistic, safe and efficient modalities for simulation-based training are highly warranted to enhance the quality of surgical education and should be incorporated in resident training. The aim of this study was to develop a patient-specific virtual cerebral aneurysm-clipping simulator with haptic force-feedback and real-time deformation of the aneurysm and vessels. METHODS: A prototype simulator was developed from 2012-2016. Evaluation of virtual clipping by blood flow simulation was integrated in this software and the prototype was evaluated by 18 neurosurgeons...
January 11, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29336332/-fatigue-syndrome-stress-burnout-and-depression-in-urology
#8
Moisés Rodríguez-Socarrás, Juan Luis Vasquez, Pieter Uvin, Pernille Skjold-Kingo, Juan Gómez Rivas
OBJECTIVE: To determine the factors related to stress, Burnout and depression in urology, as well as consequences in residents and urologists, in addition to the possible applicable strategies to diminish and treat them. ACQUISITION OF THE EVIDENCE: Depression, stress and Burnout syndrome has become a problem in urology specialty. These topics have gained interest in international congresses and urological associations. Efforts are being made to find related factors as well as possible strategies and applicable support programs...
January 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29332687/similarities-and-differences-in-estimates-of-sleep-duration-by-polysomnography-actigraphy-diary-and-self-reported-habitual-sleep-in-a-community-sample
#9
Karen A Matthews, Sanjay R Patel, Elizabeth J Pantesco, Daniel J Buysse, Thomas W Kamarck, Laisze Lee, Martica H Hall
OBJECTIVES: To compare estimates of sleep duration defined by polysomnography (PSG), actigraphy, daily diary, and retrospective questionnaire and to identify characteristics associated with differences between measures. DESIGN: Cross-sectional. SETTING: Community sample. PARTICIPANTS: The sample consisted of 223 Black, White, and Asian middle- to older-aged men and women residing in the Pittsburgh, PA area. INTERVENTIONS: Not applicable...
February 2018: Sleep Health
https://www.readbyqxmd.com/read/29332372/measurement-and-modeling-of-indoor-radon-concentrations-in-residential-buildings
#10
Ji Hyun Park, Sungim Whang, Hyun Young Lee, Cheol-Min Lee, Dae Ryong Kang
Objectives: Radon, the primary constituent of natural radiation, is the second leading environmental cause of lung cancer after smoking. To confirm a relationship between indoor radon exposure and lung cancer, estimating cumulative levels of exposure to indoor radon for an individual or population is necessary. This study sought to develop a model for estimate indoor radon concentrations in Korea. Especially, our model and method may have wider application to other residences, not to specific site, and can be used in situations where actual measurements for input variables are lacking...
January 8, 2018: Environmental Health and Toxicology
https://www.readbyqxmd.com/read/29330842/self-perceived-long-term-transfer-of-learning-after-postpartum-hemorrhage-simulation-training
#11
Brena C P Melo, Ana R Falbo, Jette Led Sorensen, Jeroen J G van Merriënboer, Cees van der Vleuten
OBJECTIVE: To explore long-term transfer (application of acquired knowledge and skills on the job) after postpartum hemorrhage simulation training based on either instructional design (ID) principles or conventional best practice. METHODS: In this qualitative study, semi-structured interviews with obstetrics and gynecology healthcare practitioners were conducted between August 7 and September 26, 2015, in Recife, Brazil. The participants were randomly selected from each of two postpartum hemorrhage simulations attended 2 years earlier (one ID and one conventional best practice)...
January 13, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29330711/boosting-tendon-repair-interplay-of-cells-growth-factors-and-scaffold-free-and-gel-based-carriers
#12
REVIEW
Zexing Yan, Heyong Yin, Michael Nerlich, Christian G Pfeifer, Denitsa Docheva
BACKGROUND: Tendons are dense connective tissues and critical components for the integrity and function of the musculoskeletal system. Tendons connect bone to muscle and transmit forces on which locomotion entirely depends. Due to trauma, overuse and age-related degeneration, many people suffer from acute or chronic tendon injuries. Owing to their hypovascularity and hypocellularity, tendinopathies remain a substantial challenge for both clinicians and researchers. Surgical treatment includes suture or transplantation of autograft, allograft or xenograft, and these serve as the most common technique for rescuing tendon injuries...
January 5, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29329571/environmental-exposures-and-fetal-growth-the-haifa-pregnancy-cohort-study
#13
Rachel Golan, Itai Kloog, Ronit Almog, Anat Gesser-Edelsburg, Maya Negev, Maya Jolles, Varda Shalev, Vered H Eisenberg, Gideon Koren, Wiessam Abu Ahmad, Hagai Levine
BACKGROUND: The developing fetus is susceptible to environmental insults. Studying the effects of environmental exposures on fetal growth is essential for understanding the causal pathway between prenatal exposures and pregnancy outcomes. Here we describe the Haifa Pregnancy Cohort Study (HPCS) and discuss challenges and opportunities in applying "big data" paradigm. METHODS: Maccabi Healthcare Services (MHS), is the second largest Israeli health maintenance organization (HMO) providing care services to two million beneficiaries...
January 12, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29329559/simplification-of-medications-prescribed-to-long-term-care-residents-simpler-study-protocol-for-a-cluster-randomised-controlled-trial
#14
Janet K Sluggett, Esa Y H Chen, Jenni Ilomäki, Megan Corlis, Sarah N Hilmer, Jan Van Emden, Choon Ean Ooi, Kim-Huong Nguyen, Tracy Comans, Michelle Hogan, Tessa Caporale, Susan Edwards, Lyntara Quirke, Allan Patching, J Simon Bell
BACKGROUND: Complex medication regimens are highly prevalent in residential aged care facilities (RACFs). Strategies to reduce unnecessary complexity may be valuable because complex medication regimens can be burdensome for residents and are costly in terms of nursing time. The aim of this study is to investigate application of a structured process to simplify medication administration in RACFs. METHODS: SImplification of Medications Prescribed to Long-tErm care Residents (SIMPLER) is a non-blinded, matched-pair, cluster randomised controlled trial of a single multidisciplinary intervention to simplify medication regimens...
January 12, 2018: Trials
https://www.readbyqxmd.com/read/29328018/-a-day-in-the-life-of-a-medical-resident-on-the-ward
#15
A R Schuurman, S A Bos, K de Wit, R de Graaf, W J Wiersinga
OBJECTIVE: To investigate how internal medicine residents allocate their time during a hospital dayshift on the wards. DESIGN: Prospective observational cohort study (time and motion study). METHODS: Data were collected from 36 internal medicine residents working at the Internal Medicine Department of the Academic Medical Centre in Amsterdam, the Netherlands. Trained observers monitored 22 residents using a newly developed smartphone-application, registering their dayshift activities (meetings and education, direct patient contact, administrative tasks, lunch/break, other) and location (workstation, conference room, ward and patient rooms, other)...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29326514/modified-angle-s-classification-for-primary-dentition
#16
Kaushik Narendra Chandranee, Narendra Jayantilal Chandranee, Devendra Nagpal, Gagandeep Lamba, Purva Choudhari, Kavita Hotwani
Aim: This study aims to propose a modification of Angle's classification for primary dentition and to assess its applicability in children from Central India, Nagpur. Methods: Modification in Angle's classification has been proposed for application in primary dentition. Small roman numbers i/ii/iii are used for primary dentition notation to represent Angle's Class I/II/III molar relationships as in permanent dentition, respectively. To assess applicability of modified Angle's classification a cross-sectional preschool 2000 children population from central India; 3-6 years of age residing in Nagpur metropolitan city of Maharashtra state were selected randomly as per the inclusion and exclusion criteria...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29326140/navigating-the-residency-application-process-for-lesbian-gay-bisexual-and-transgender-student-pharmacists
#17
Calvin C Daniels, Tate N Trujillo, Christopher M Scott, Lindsey R Kelley
No abstract text is available yet for this article.
January 11, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29325541/interprofessional-collaboration-in-nursing-homes-interprof-development-and-piloting-of-measures-to-improve-interprofessional-collaboration-and-communication-a-qualitative-multicentre-study
#18
Christiane A Müller, Nina Fleischmann, Christoph Cavazzini, Susanne Heim, Svenja Seide, Christina Geister, Britta Tetzlaff, Andreas Hoell, Jochen Werle, Siegfried Weyerer, Martin Scherer, Eva Hummers
BACKGROUND: Given both the increase of nursing home residents forecast and challenges of current interprofessional interactions, we developed and tested measures to improve collaboration and communication between nurses and general practitioners (GPs) in this setting. Our multicentre study has been funded by the German Federal Ministry of Education and Research (FK 01GY1124). METHODS: The measures were developed iteratively in a continuous process, which is the focus of this article...
January 11, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29324559/nurse-experiences-of-medication-administration-to-people-with-swallowing-difficulties-living-in-aged-care-facilities-a-systematic-review-of-qualitative-evidence
#19
Aida Sefidani Forough, Simon Y M Wong, Esther T L Lau, Jose Manuel Serrano Santos, Greg J Kyle, Kathryn J Steadman, Julie A Y Cichero, Lisa M Nissen
OBJECTIVE: To identify nurses' experiences of administering oral medications to residents of aged care facilities (ACFs) with swallowing difficulties. INTRODUCTION: Administering medicines to older people with swallowing difficulties is a challenging task. Nurses frequently modify oral medications e.g. by crushing/splitting tablets or opening capsules, to facilitate the administration process. These practices are associated with an increased risk of medication administration errors...
January 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29322915/comparison-alignment-and-synchronization-of-cell-line-information-between-clo-and-efo
#20
Edison Ong, Sirarat Sarntivijai, Simon Jupp, Helen Parkinson, Yongqun He
BACKGROUND: The Experimental Factor Ontology (EFO) is an application ontology driven by experimental variables including cell lines to organize and describe the diverse experimental variables and data resided in the EMBL-EBI resources. The Cell Line Ontology (CLO) is an OBO community-based ontology that contains information of immortalized cell lines and relevant experimental components. EFO integrates and extends ontologies from the bio-ontology community to drive a number of practical applications...
December 21, 2017: BMC Bioinformatics
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