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https://www.readbyqxmd.com/read/28724718/poor-reliability-and-poor-adherence-to-self-monitoring-of-blood-glucose-are-common-in-women-with-gestational-diabetes-mellitus-and-may-be-associated-with-poor-pregnancy-outcomes
#1
Emmanuel Cosson, Baz Baz, Françoise Gary, Isabelle Pharisien, Minh Tuan Nguyen, Dorian Sandre-Banon, Yahya Jaber, Camille Cussac-Pillegand, Isabela Banu, Lionel Carbillon, Paul Valensi
OBJECTIVE: To evaluate the compliance with self-monitoring of blood glucose (SMBG) and the reliability of diabetes logbooks in women with gestational diabetes mellitus (GDM), as well as the associated determinants and outcomes. RESEARCH DESIGN AND METHODS: We prospectively selected French-speaking women with newly diagnosed GDM who had been referred to our diabetes management program and understood SMBG principles. At the next follow-up visit, we collected SMBG results from glucose meters and logbooks...
July 19, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28713290/advanced-maternal-age-worsens-postpartum-vascular-function
#2
Jude S Morton, Alison S Care, Raven Kirschenman, Christy-Lynn Cooke, Sandra T Davidge
The age at which women experience their first pregnancy has increased throughout the decades. Pregnancy has an important influence on maternal short- and long-term cardiovascular outcomes. Pregnancy at an advanced maternal age increases maternal risk of gestational diabetes, preeclampsia, placenta previa and caesarian delivery; complications which predict worsened cardiovascular health in later years. Aging also independently increases the risk of cardiovascular disease; therefore, combined risk in women of advanced maternal age may lead to detrimental cardiovascular outcomes later in life...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28711148/a-review-of-systemic-corticosteroid-use-in-pregnancy-and-the-risk-of-select-pregnancy-and-birth-outcomes
#3
REVIEW
Gretchen Bandoli, Kristin Palmsten, Chelsey J Forbess Smith, Christina D Chambers
The evidence to date regarding corticosteroid exposure in pregnancy and select pregnancy and birth outcomes is limited and inconsistent. The authors provide a narrative review of published literature summarizing the findings for oral clefts, preterm birth, birth weight, preeclampsia, and gestational diabetes mellitus. Whenever possible, the results are limited to oral or systemic administration with a further focus on use in autoimmune disease. Although previous studies of corticosteroid exposure in pregnancy reported an increased risk of oral clefts in the offspring, more recent studies have not replicated these findings...
August 2017: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/28706364/prediction-of-preeclampsia-in-early-pregnancy-by-estimating-the-spot-urinary-albumin-creatinine-ratio
#4
Nupur Gupta, Taru Gupta, Deepti Asthana
OBJECTIVE: To assess whether a spot urinary albumin:creatinine ratio (ACR) measured before 20 weeks of gestation can predict subsequent development of preeclampsia. METHODS: The ACR was determined from midstream urine sample taken between 17 and 20 weeks of gestation. Urine albumin was measured by immunoturbidimetric method using commercially available kit (Beckman Coulter) through Beckman AU 480 fully automated biochemistry analyzer. Urine creatinine was measured by modified kinetic Jaffe reaction without deproteinization...
August 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28698954/principles-of-first-trimester-screening-in-the-age-of-non-invasive-prenatal-diagnosis-screening-for-other-major-defects-and-pregnancy-complications
#5
REVIEW
Karl Oliver Kagan, Jiri Sonek, Philipp Wagner, Markus Hoopmann
PURPOSE: First trimester risk assessment plays a major role in the contemporary pregnancy care. It has evolved significantly since its introduction in the 1990s when it essentially consisted of just the nuchal translucency measurement. Today, it involves the measurement of several biophysical and biochemical markers and can assess the risk for a wide array of major chromosomal and non-chromosomal defects as well as other pregnancy-related complications. METHODS: A search of the Medline and Embase databases was done looking for articles about first trimester screening...
July 11, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28696852/imaging-of-pregnancy-related-vascular-complications
#6
R Scooter Plowman, Cylen Javidan-Nejad, Constantine A Raptis, Douglas S Katz, Vincent M Mellnick, Sanjeev Bhalla, Patricia Cornejo, Christine O Menias
Pregnancy results in substantial hemodynamic and prothrombotic changes that form the foundation for downstream vascular complications, both during pregnancy and in the postpartum period. In addition, several important risk factors, including older patient age, diabetes, and smoking, can increase the risk for vascular-related pregnancy complications. Because radiologists often play an important role in evaluation of the pregnant patient, understanding the pathophysiology of vascular-related complications in pregnancy and their imaging appearances is essential for diagnostic accuracy...
July 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28675948/use-of-prokineticin-1-prok1-pregnancy-associated-plasma-protein-a-papp-a-and-prok1-papp-a-ratio-to-predict-adverse-pregnancy-outcomes-in-the-first-trimester-a-prospective-study
#7
Cihan Inan, Fusun Gulizar Varol, Selen Gursoy Erzincan, Isil Uzun, Havva Sutcu, N Cenk Sayin
INTRODUCTION: To compare the predictive effectiveness levels of prokineticin-1 (PROK1), pregnancy-associated plasma protein A (PAPP-A) and the PROK1/PAPP-A ratio in the first trimester for preeclampsia (PE), fetal growth restriction (FGR), gestational diabetes mellitus (GDM) and spontaneous preterm birth (SPB). MATERIAL AND METHODS: A total of randomly selected 162 pregnant women were included. Peripheral blood samples were obtained between 110/(7) and 13(6/7) gestational weeks (GWs)...
July 4, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28672769/reference-intervals-and-longitudinal-changes-in-copeptin-and-mr-proadm-concentrations-during-pregnancy
#8
Annemiek M C P Joosen, Ivon J M van der Linden, Lianne Schrauwen, Alisia Theeuwes, Monique J M de Groot, Antonius A M Ermens
BACKGROUND: Vasopressin and adrenomedullin and their stable by-products copeptin and midregional part of proadrenomedullin (MR-proADM) are promising biomarkers for the development of preeclampsia. However, clinical use is hampered by the lack of trimester-specific reference intervals. We therefore estimated reference intervals for copeptin and MR-proADM in disease-free Dutch women throughout pregnancy. METHODS: Apparently healthy low risk pregnant women were recruited...
June 16, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28672292/association-between-pregnancy-and-perinatal-outcomes-among-women-with-epilepsy
#9
Neda Razaz, Torbjörn Tomson, Anna-Karin Wikström, Sven Cnattingius
Importance: To date, few attempts have been made to examine associations between exposure to maternal epilepsy with or without antiepileptic drug (AED) therapy and pregnancy and perinatal outcomes. Objectives: To investigate associations between epilepsy in pregnancy and risks of pregnancy and perinatal outcomes as well as whether use of AEDs influenced risks. Design, Setting, and Participants: A population-based cohort study was conducted on all singleton births at 22 or more completed gestational weeks in Sweden from 1997 through 2011; of these, 1 424 279 were included in the sample...
July 3, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28659928/gestational-diabetes-mellitus-is-associated-with-altered-neutrophil-activity
#10
Maria Stoikou, Franco Grimolizzi, Stavros Giaglis, Günther Schäfer, Shane Vontelin van Breda, Irene Mathilde Hoesli, Olav Lapaire, Evelyn A Huhn, Paul Hasler, Simona W Rossi, Sinuhe Hahn
Gestational diabetes mellitus (GDM) is a unique form of glucose intolerance, in that it is transient and solely occurs in pregnancy. Pregnancies with GDM are at high risk of developing preeclampsia (PE), a leading cause of fetal and maternal morbidity or mortality. Since PE is associated with excessive activation of circulatory neutrophils and occurrence of neutrophil extracellular traps (NETs) in affected placentae, we examined these features in cases with GDM, as this could be a feature linking the two conditions...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28629273/the-association-between-maternal-race-and-adverse-outcomes-in-twin-pregnancies-with-similar-healthcare-access
#11
Marti D Soffer, Mariam Naqvi, Stephanie Melka, Aren Gottlieb, Julie Romero, Nathan S Fox
OBJECTIVE: To compare twin pregnancy outcomes between white and nonwhite women with similar access to healthcare. METHODS: Retrospective cohort study of all twin pregnancies delivered by a single maternal-fetal medicine practice from 2005-2016. All patients had private health insurance and equal access to physician care. Outcomes were compared between white and nonwhite women using logistic regression to adjust for differences at baseline. RESULTS: Of the 858 women included, 730 (85...
June 19, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28619690/metformin-the-aspirin-of-the-21st-century-its%C3%A2-role-in-gestational-diabetes-mellitus-prevention-of-preeclampsia-and-cancer-and%C3%A2-the-promotion-of-longevity
#12
REVIEW
Roberto Romero, Offer Erez, Maik Hüttemann, Eli Maymon, Bogdan Panaitescu, Agustin Conde-Agudelo, Percy Pacora, Bo Hyun Yoon, Lawrence I Grossman
Metformin is everywhere. Originally introduced in clinical practice as an antidiabetic agent, its role as a therapeutic agent is expanding to include treatment of prediabetes mellitus, gestational diabetes mellitus, and polycystic ovarian disease and, more recently, experimental studies and observations in randomized clinical trials suggest that metformin could have a place in the treatment or prevention of preeclampsia. This article provides a brief overview of the history of metformin in the treatment of diabetes mellitus, reviews the results of metaanalyses of metformin in gestational diabetes mellitus, and the treatment of obese non-diabetic pregnant women to prevent macrosomia...
June 12, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28600043/placenta-associated-pregnancy-complications-in-pregnancies-complicated-with-placenta-previa
#13
Yael Baumfeld, Reli Herskovitz, Zehavi Bar Niv, Salvatore Andrea Mastrolia, Adi Y Weintraub
OBJECTIVES: The purpose of our study was to examine the hypothesis that pregnancies complicated with placenta previa have an increased risk of placental insufficiency associated pregnancy complications (IUGR, preeclampsia, placental abruption and perinatal mortality). MATERIALS AND METHODS: Our study included all deliveries that occurred at Soroka University Medical Center (Beer Sheva, Israel) between January 1998 and December 2013. Of them 1,249 were complicated by placenta previa and represented our study group...
June 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28599896/objectively-measured-short-sleep-duration-and-later-sleep-midpoint-in-pregnancy-are-associated-with-a-higher-risk-of-gestational-diabetes
#14
Francesca L Facco, William A Grobman, Kathryn J Reid, Corette B Parker, Shannon M Hunter, Robert M Silver, Robert C Basner, George R Saade, Grace W Pien, Shalini Manchanda, Judette M Louis, Chia-Ling Nhan-Chang, Judith H Chung, Deborah A Wing, Hyagriv N Simhan, David M Haas, Jay Iams, Samuel Parry, Phyllis C Zee
BACKGROUND: Experimental and epidemiologic data suggest that among nonpregnant adults, sleep duration may be an important risk factor for chronic disease. Although pregnant women commonly report poor sleep, few studies objectively evaluated the quality of sleep in pregnancy or explored the relationship between sleep disturbances and maternal and perinatal outcomes. OBJECTIVE: Our objective was to examine the relationship between objectively assessed sleep duration, timing, and continuity (measured via wrist actigraphy) and maternal cardiovascular and metabolic morbidity specific to pregnancy...
June 7, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28599894/impact-of-aspirin-on-fetal-growth-in-diabetic-pregnancies-according-to-white-classification
#15
Katlynn Adkins, Amanda A Allshouse, Torri D Metz, Kent D Heyborne
BACKGROUND: Current US Preventive Services Task Force and other guidelines recommend low-dose aspirin for all pregnant women with pregestational diabetes mellitus to prevent preeclampsia and small-for-gestational-age birth. The Maternal-Fetal Medicine Units High-Risk Aspirin trial did not show a reduction in either preeclampsia or small-for-gestational-age birth in diabetic women. OBJECTIVE: Our objective was to reassess the impact of aspirin on fetal growth in diabetic pregnancies overall and according to White classification...
June 30, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28594772/gestational-diabetes-mellitus-and-frequency-of-blood-glucose-monitoring-a-randomized-controlled-trial
#16
Hector Mendez-Figueroa, Meike Schuster, Lindsay Maggio, Claudia Pedroza, Suneet P Chauhan, Michael J Paglia
OBJECTIVE: To assess whether testing blood glucose four times daily compared with four times every other day would lead to similar birth weights among patients with gestational diabetes mellitus (GDM). METHODS: This noninferiority randomized controlled trial was conducted at five centers. After receiving a diagnosis of GDM, women tested their blood glucose every day for 7 days. After that period, compliant women without hyperglycemia requiring treatment were randomized to either blood glucose testing four times a day or every other day...
July 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28593917/vitamin-d-deficiency-in-pregnancy-at-term-risk-factors-and-pregnancy-outcomes
#17
Chui Ling Lee, Beng Kwang Ng, Loo Ling Wu, Fook Choe Cheah, Hanita Othman, Nor Azlin Mohamed Ismail
Background Vitamin D deficiency during pregnancy is a worldwide epidemic. The aim of this study was to determine the prevalence of vitamin D deficiency, its predictive factors and the association with pregnancy outcomes. Materials and methods This was a prospective observational study in a tertiary teaching hospital over 2-years' duration from August 2013 to August 2015. A total of 680 women who completed 37 weeks of pregnancy were recruited. Results Five hundred and seventy-five patients were enrolled in the final analysis for pregnancy outcomes (response rate of 84...
May 26, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28591252/impact-of-the-use-of-different-diagnostic-criteria-in-the-prevalence-of-dyslipidemia-in-pregnant-women
#18
Alina Coutinho Rodrigues Feitosa, Luciana Tedgue Barreto, Isabela Matos da Silva, Felipe Freire da Silva, Gilson Soares Feitosa
Background: There is a physiologic elevation of total cholesterol (TC) and triglycerides (TG) during pregnancy. Some authors define dyslipidemia (DLP) in pregnant women when TC, LDL and TG concentrations are above the 95th percentile (p95%) and HDL concentration is below the 5th percentile (P5%) for gestational age (GA). Objective: To compare the prevalence of DLP in pregnant women using percentiles criteria with the V Brazilian Guidelines on Dyslipidemia and the association with maternal and fetal outcomes...
June 1, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28585734/immunological-function-of-vitamin-d-during-human-pregnancy
#19
Jin-Lu Ji, Kahinho P Muyayalo, Yong-Hong Zhang, Xiao-Hui Hu, Ai-Hua Liao
The well-established classic role of vitamin D is implicated in the regulation of the balance between calcium and phosphorus. Furthermore, vitamin D is also involved in many non-classic physiological processes, mainly including the regulation of cell proliferation, differentiation, apoptosis and immune function, participation in the inflammatory response and maintenance of genome stability function. During pregnancy, vitamin D receptor and its metabolic enzymes are expressed at the placenta and decidua, indicating the potential role in the mechanism of immunomodulation at the maternal-fetal interface...
June 6, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28570835/lifestyle-and-behavioral-management-of-polycystic-ovary-syndrome
#20
Leah Brennan, Helena Teede, Helen Skouteris, Jake Linardon, Briony Hill, Lisa Moran
Polycystic ovary syndrome (PCOS) is a common condition with serious physiological and psychological health consequences. It affects women across their reproductive lifespan and is associated with pregnancy complications, including gestational diabetes, preeclampsia, and large gestational-age babies. PCOS is associated with excess weight gain, which, in turn, exacerbates the health burden of PCOS. Therefore, weight management, including a modest weight loss, maintenance of weight loss, prevention of weight gain, and prevention of excess gestational weight gain, is a first-line treatment for women with PCOS during and independent of pregnancy...
June 1, 2017: Journal of Women's Health
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