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https://www.readbyqxmd.com/read/28218564/-a-brief-of-gestational-diabetes-mellitus-risk-factors-and-current-criteria-of-diagnosis
#1
Zahra Al-Aissa, Orsolya Hadarits, Klára Rosta, András Zóka, János Rigó, Gábor Firneisz, Anikó Somogyi
Diabetes is one of the most common metabolic disorders that may cause pathological pregnancy. Treating diabetes recognized during pregnancy results in lowering maternal and fetal complications. These patients present higher risk for excessive weight gain, preeclampsia, delivery with cesarean sections, high risk of developing type 2 diabetes and cardiovascular disease in the future. Fetuses of mothers with gestational diabetes are at higher risk for macrosomia and birth trauma, after delivery they present higher risk of developing neonatal hypoglycemia, hyperbilirubinemia, and respiratory distress syndrome...
February 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28178044/interpregnancy-interval-and-adverse-pregnancy-outcomes-an-analysis-of-successive-pregnancies
#2
Gillian E Hanley, Jennifer A Hutcheon, Brooke A Kinniburgh, Lily Lee
OBJECTIVE: To examine the association between interpregnancy interval and maternal-neonate health when matching women to their successive pregnancies to control for differences in maternal risk factors and compare these results with traditional unmatched designs. METHODS: We conducted a retrospective cohort study of 38,178 women with three or more deliveries (two or greater interpregnancy intervals) between 2000 and 2015 in British Columbia, Canada. We examined interpregnancy interval (0-5, 6-11, 12-17, 18-23 [reference], 24-59, and 60 months or greater) in relation to neonatal outcomes (preterm birth [less than 37 weeks of gestation], small-for-gestational-age birth [less than the 10th centile], use of neonatal intensive care, low birth weight [less than 2,500 g]) and maternal outcomes (gestational diabetes, beginning the subsequent pregnancy obese [body mass index 30 or greater], and preeclampsia-eclampsia)...
March 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28137991/association-of-pregnancy-complications-and-characteristics-with-future-risk-of-elevated-blood-pressure-the-v%C3%A3-sterbotten-intervention-program
#3
Nisha I Parikh, Margareta Norberg, Erik Ingelsson, Sven Cnattingius, Ramachandran S Vasan, Magnus Domellöf, Jan Håkan Jansson, Anna-Karin Edstedt Bonamy
Pregnancy characteristics are associated with risk of cardiovascular diseases, but their independent associations with hypertension or blood pressure (BP) levels remain uncertain. We linked the Swedish Medical Birth Register with Västerbotten Intervention Program data (Northern Sweden). Using linear and logistic regression, we related pregnancy factors in any prior pregnancy with BP and hypertension at 40 years of age in 15 896 parous women free of prepregnancy hypertension. Pregnancy factors included parity, age at first delivery, preeclampsia, gestational diabetes mellitus, placental abruption, shortest gestational age small for gestational age baby (<third percentile for birth weight) or stillbirth...
March 2017: Hypertension
https://www.readbyqxmd.com/read/28133615/pregnancy-during-adolescence-and-associated-risks-an-8-year-hospital-based-cohort-study-2007-2014-in-romania-the-country-with-the-highest-rate-of-teenage-pregnancy-in-europe
#4
Demetra-Gabriela Socolov, Magdalena Iorga, Alexandru Carauleanu, Ciprian Ilea, Iolanda Blidaru, Lucian Boiculese, Razvan-Vladimir Socolov
Aim. To determine pregnancy and delivery outcomes among teenagers. Materials and Methods. An 8-year retrospective comparative hospital-based cohort study is analysing singleton pregnancy comorbidities and delivery parameters of a teenage group under the age of 20 compared with a young adult group 20-24 years of age in a university hospital. Results. Teenage is a risk factor for preterm birth <37 weeks (1.21 [1.08-1.35]), foetal growth restriction (1.34 [1.21-1.48]), episiotomy (1.27 [1.21-1.34]), uterine revision (1...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28120286/adverse-perinatal-outcomes-and-postpartum-multi-systemic-dysregulation-adding-vitamin-d-deficiency-to-the-allostatic-load-index
#5
Eynav Elgavish Accortt, James Mirocha, Christine Dunkel Schetter, Calvin J Hobel
Background Allostatic load (AL) is an index of multi-system physiological "wear-and-tear," operationalizing emergent chronic disease risk and predicting morbidity and mortality. AL has been proposed as an organizing framework for studying pregnancy outcomes and additional AL biomarkers for the study of maternal health would be valuable. Objectives To test whether adverse perinatal outcomes are associated with postpartum AL and if including vitamin D deficiency (serum 25(OH)D < 20 ng/ml) as an additional marker of postpartum AL increases the association...
January 24, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28117144/review-alterations-in-placental-glycogen-deposition-in-complicated-pregnancies-current-preclinical-and-clinical-evidence
#6
REVIEW
Lisa K Akison, Marloes Dekker Nitert, Vicki L Clifton, Karen M Moritz, David G Simmons
Normal placental function is essential for optimal fetal growth. Transport of glucose from mother to fetus is critical for fetal nutrient demands and can be stored in the placenta as glycogen. However, the function of this glycogen deposition remains a matter of debate: It could be a source of fuel for the placenta itself or a storage reservoir for later use by the fetus in times of need. While the significance of placental glycogen remains elusive, mounting evidence indicates that altered glycogen metabolism and/or deposition accompanies many pregnancy complications that adversely affect fetal development...
January 11, 2017: Placenta
https://www.readbyqxmd.com/read/28117143/review-placental-derived-biomarkers-of-pregnancy-disorders
#7
REVIEW
James S M Cuffe, Olivia Holland, Carlos Salomon, Gregory E Rice, Anthony V Perkins
Pregnancy is one of the greatest physiological challenges that a women can experience. The physiological adaptations that accompany pregnancy may increase the risk of developing a number of disorders that can lead to both acute and chronic physiological outcomes. In addition, fetal development may be impaired and, if the fetus survives, the child may be at an increased risk of disease throughout life. Pregnancy disorders are poorly predicted by traditional risk factors and maternal history alone. The identification of biomarkers that can predict incidence and severity of disease would allow for improved and targeted prophylactic therapies to prevent adverse maternal and fetal outcomes...
January 16, 2017: Placenta
https://www.readbyqxmd.com/read/28112874/duration-of-puberty-in-preterm-girls
#8
L L Hui, H S Lam, G M Leung, C M Schooling
OBJECTIVES: Preterm birth is associated with altered pubertal timing, but the effect on pubertal duration has rarely been assessed. Here, we tested the hypothesis that preterm birth is associated with shorter duration of puberty among girls in Hong Kong where preterm birth has little social patterning. METHODS: In the population-representative Chinese birth cohort "Children of 1997", we used multivariable linear regression to assess the association of preterm status (≤36 completed gestational weeks, n = 170; term birth 37-42 gestational weeks, n = 3476) with duration of puberty, adjusted for parent's highest education, mother's place of birth, maternal smoking during pregnancy, gestational diabetes, preeclampsia, and mother's age of menarche...
January 23, 2017: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/28110750/role-of-exosomes-in-placental-homeostasis-and-pregnancy-disorders
#9
C Salomon, G E Rice
The human placenta is a unique organ that performs the function of the majority of fetal organs across gestation. How the placenta communicates with maternal tissues to prepare them for pregnancy is not fully understood. Recently, it has been established that placental cells can communicate with maternal tissues to regulate their biological function via extracellular vesicles (EVs). EVs are subclassified into exosomes or microvesicles (MVs) according to their size, cell or tissue of origin, functions, and physical features...
2017: Progress in Molecular Biology and Translational Science
https://www.readbyqxmd.com/read/28110597/sleep-quality-and-its-relationship-with-quality-of-life-among-high-risk-pregnant-women-gestational-diabetes-and-hypertension
#10
Fatemeh Saadati, Fahimeh Sehhatiei Shafaei, Mozhgan Mirghafourvand
BACKGROUND: Sleep is one of the most basic human requirements. This research aims at determining the status of sleep quality and its relationship with quality of life among high-risk pregnant women in Tabriz, Iran, in 2015. MATERIALS AND METHODS: This research was a sectional study done on 364 qualified women in 28-36 weeks of pregnancy suffering from mild preeclampsia and gestational diabetes. The sampling was done as convenience. Personal-social-midwifery questionnaire, Pittsburg sleep quality, and quality of life in pregnancy (QOL-ORAV) were used for gathering data...
January 23, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28040612/association-of-obstructive-sleep-apnea-with-adverse-pregnancy-related-outcomes-in-military-hospitals
#11
Dennis L Spence, Rhonda C Allen, Monica A Lutgendorf, Virginia R Gary, John D Richard, Sara C Gonzalez
BACKGROUND: Obstructive sleep apnea (OSA) is associated with significant morbidity and mortality in non-obstetrical and obstetrical patients. OBJECTIVES: To estimate the prevalence of OSA and its relationship with pregnancy-related complications in a general obstetric population of Department of Defense beneficiaries receiving direct-care at military treatment facilities. STUDY DESIGN: A retrospective cohort study of all women (N=305,001) who gave birth at a military treatment facility from 2008 to 2014...
December 14, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28034467/review-maternal-health-and-the-placental-microbiome
#12
REVIEW
Elise Pelzer, Luisa F Gomez-Arango, Helen L Barrett, Marloes Dekker Nitert
Over the past decade, the role of the microbiome in regulating metabolism, immune function and behavior in humans has become apparent. It has become clear that the placenta is not a sterile organ, but rather has its own endogenous microbiome. The composition of the placental microbiome is distinct from that of the vagina and has been reported to resemble the oral microbiome. Compared to the gut microbiome, the placental microbiome exhibits limited microbial diversity. This review will focus on the current understanding of the placental microbiota in normal healthy pregnancy and also in disease states including preterm birth, chorioamnionitis and maternal conditions such as obesity, gestational diabetes mellitus and preeclampsia...
December 2, 2016: Placenta
https://www.readbyqxmd.com/read/28031980/obesity-epidemic-impact-from-preconception-to-postpartum
#13
REVIEW
Hind N Moussa, Mesk A Alrais, Mateo G Leon, Elizabeth L Abbas, Baha M Sibai
The obesity epidemic is on the rise throughout the USA and the world. Not only does it affect the general population but it also specifically poses unique threats to a woman's life in the antepartum, peripartum and postpartum periods. An increased BMI is associated with worse perinatal outcomes, including higher rates of preeclampsia (and other hypertensive disorders), macrosomia, other neonatal morbidities and gestational diabetes. Isolated maternal obesity and additional maternal diabetes predispose the infant to potential adult disease through fetal programming...
September 2016: Future Science OA
https://www.readbyqxmd.com/read/28031147/review-effects-of-maternal-micronutrient-supplementation-on-placental-function
#14
REVIEW
Kerry Richard, Olivia Holland, Kelly Landers, Jessica J Vanderlelie, Pierre Hofstee, James S M Cuffe, Anthony V Perkins
Pregnancy is a physiological challenge that may require additional nutritional support. Suboptimal micronutrient intakes and micronutrient deficiencies during pregnancy are a global problem, often leading to poor maternal and child outcomes. Micronutrient supplementation is commonly recommended during pregnancy to support and enhance maternal metabolism. Recent studies suggest that the use of multiple micronutrient supplements may be of benefit during a normal pregnancy and may significantly reduce the risk of preeclampsia, preterm delivery, gestational diabetes, and improve pregnancy outcomes...
December 20, 2016: Placenta
https://www.readbyqxmd.com/read/28024805/review-placental-mitochondrial-function-and-structure-in-gestational-disorders
#15
REVIEW
Olivia Holland, Marloes Dekker Nitert, Linda A Gallo, Meliha Vejzovic, Joshua J Fisher, Anthony V Perkins
The aetiology of many gestational disorders is still unknown. However, insufficient trans-placental nutrient and oxygen transfer due to abnormal placentation is characteristic of several pathologies, and may alter the function of placental mitochondria. Mitochondria are multifunctional organelles that respond to a wide range of stimuli - such as physiological changes in cellular energy demands or various pathologies - by reshaping via fusion or fission, increasing/decreasing in number, altering oxidative phosphorylation, and signalling cellular functions such as apoptosis...
December 14, 2016: Placenta
https://www.readbyqxmd.com/read/28008002/pregnancy-outcomes-after-clinical-recovery-from-aki
#16
Jessica Sheehan Tangren, Camille E Powe, Elizabeth Ankers, Jeffrey Ecker, Kate Bramham, Michelle A Hladunewich, S Ananth Karumanchi, Ravi Thadhani
The effect of clinically recovered AKI (r-AKI) on future pregnancy outcomes is unknown. We retrospectively studied all women who delivered infants between 1998 and 2007 at Massachusetts General Hospital to assess whether a previous episode of r-AKI associated with subsequent adverse maternal and fetal outcomes, including preeclampsia. AKI was defined as rise in serum creatinine concentration to 1.5-fold above baseline. We compared pregnancy outcomes in women with r-AKI without history of CKD (eGFR>90 ml/min per 1...
December 22, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28002314/association-between-polycystic-ovary-syndrome-and-the-risk-of-pregnancy-complications-a-prisma-compliant-systematic-review-and-meta-analysis
#17
REVIEW
Hai-Feng Yu, Hong-Su Chen, Da-Pang Rao, Jian Gong
BACKGROUND: Polycystic ovary syndrome (PCOS) is inconsistently associated with increased risk of adverse pregnancy outcomes. The purpose of this meta-analysis was to summarize the evidence regarding the strength of the association between pregnancy in women with PCOS and pregnancy complications. METHODS: We systematically searched PubMed, EmBase, and the Cochrane Library to identify observational studies up to January 2016. The primary focus was pregnancy outcomes, including gestational diabetes mellitus (GDM), preeclampsia, pregnancy-induced hypertension (PIH), preterm delivery, cesarean delivery, oligohydramnios, and polyhydramnios...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27968898/single-fasting-plasma-glucose-measurement-compared-with-75-g-oral-glucose-tolerance-test-in-prediction-of-adverse-perinatal-outcomes-a-prospective-cohort-study-from-china
#18
Songying Shen, Jinhua Lu, Lifang Zhang, Jianrong He, Weidong Li, Niannian Chen, Xingxuan Wen, Wanqing Xiao, Mingyang Yuan, Lan Qiu, Kar Keung Cheng, Huimin Xia, Ben Willem J Mol, Xiu Qiu
BACKGROUND: The prevalence of gestational diabetes mellitus has increased markedly in recent years in China, mainly because of the introduction of new diagnostic criteria. We aimed to evaluate whether in the diagnosis of gestational diabetes mellitus, 1h and 2h glucose measurements have additional value compared with a single fasting plasma glucose measurement. METHODS: We included data from 6993 pregnant women who underwent a 2h 75g oral glucose-tolerance test at 22-28 weeks' gestation in the Born in Guangzhou Cohort Study in China...
October 2016: Lancet
https://www.readbyqxmd.com/read/27941633/a-prospective-study-on-serum-methylmalonic-acid-and-homocysteine-in-pregnant-women
#19
Rihwa Choi, Sunkyu Choi, Yaeji Lim, Yoon Young Cho, Hye Jeong Kim, Sun Wook Kim, Jae Hoon Chung, Soo-Young Oh, Soo-Youn Lee
This study aimed to investigate serum methylmalonic acid (MMA) and homocysteine levels and to assess their effects on pregnancy and neonatal outcomes. Serum MMA and homocysteine levels in 278 pregnant Korean women, determined by liquid chromatography-tandem mass spectrometry in each trimester, were compared with those of previous studies in other ethnic groups. We investigated the association between MMA and homocysteine status with pregnancy and neonatal events: gestational diabetes, preeclampsia, gestational age at delivery, preterm birth, small for gestational age, neonatal birth weight, and congenital abnormalities...
December 8, 2016: Nutrients
https://www.readbyqxmd.com/read/27939485/postpartum-physiology-psychology-and-paediatric-follow-up-study-p4-study-study-protocol
#20
Gregory K Davis, Lynne Roberts, George Mangos, Amanda Henry, Franziska Pettit, Anthony O'Sullivan, Caroline S E Homer, Maria Craig, Samuel B Harvey, Mark A Brown
BACKGROUND: Women who have had hypertension in pregnancy are at greater risk of long term cardiovascular disease (CVD). Little is known about their cardiovascular risk postpartum or the effects on the woman's mental health and the outcomes of their infants. In this project we will study the physiological and psychological health of women and the physical health and development of their infants six months, two years and five years after birth. We will establish normal blood pressure (BP) and metabolic function for women who were normotensive in pregnancy and use these to assess women who had gestational hypertension (GH) or preeclampsia (PE)...
October 2016: Pregnancy Hypertension
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