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https://www.readbyqxmd.com/read/28444796/determination-of-volatile-flavour-profiles-of-citrus-spp-fruits-by-sde-gc-ms-and-enantiomeric-composition-of-chiral-compounds-by-mdgc-ms
#1
Joon Ho Hong, Naeem Khan, Nargis Jamila, Young Shin Hong, Eun Yeong Nho, Ji Yeon Choi, Cheong Mi Lee, Kyong Su Kim
INTRODUCTION: Citrus fruits are known to have characteristic enantiomeric key compounds biosynthesised by highly stereoselective enzymatic mechanisms. In the past, evaluation of the enantiomeric ratios of chiral compounds in fruits has been applied as an effective indicator of adulteration by the addition of synthetic compounds or natural components of different botanical origin. OBJECTIVE: To analyse the volatile flavour compounds of Citrus junos Sieb. ex Tanaka (yuzu), Citrus limon BURM...
April 25, 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/28442604/hepatitis-c-virus-indirectly-disrupts-dna-damage-induced-p53-responses-by-activating-protein-kinase-r
#2
Jonathan K Mitchell, Bentley R Midkiff, Benjamin Israelow, Matthew J Evans, Robert E Lanford, Christopher M Walker, Stanley M Lemon, David R McGivern
Many DNA tumor viruses promote cellular transformation by inactivating the critically important tumor suppressor protein p53. In contrast, it is not known whether p53 function is disrupted by hepatitis C virus (HCV), a unique, oncogenic RNA virus that is the leading infectious cause of liver cancer in many regions of the world. Here we show that HCV-permissive, liver-derived HepG2 cells engineered to constitutively express microRNA-122 (HepG2/miR-122 cells) have normal p53-mediated responses to DNA damage and that HCV replication in these cells potently suppresses p53 responses to etoposide, an inducer of DNA damage, or nutlin-3, an inhibitor of p53 degradation pathways...
April 25, 2017: MBio
https://www.readbyqxmd.com/read/28438043/comparative-effectiveness-and-safety-analysis-of-dual-antiplatelet-therapies-within-an-integrated-delivery-system
#3
James C Coons, Carlo J Iasella, Tyler Chanas, Nan Wang, Kiersten Williams, Anthony Boyd, John Lyons, Jamie Eckardt, Lindsey Rihtarchik, Alison Merkel, Alexandra Chambers, Lara S Lemon, Randall Smith, Christopher R Ensor
BACKGROUND: Dual antiplatelet therapy is a mainstay of care for percutaneous coronary intervention (PCI) patients; however, uncertainty exists in real-world practice about comparative effectiveness and safety outcomes. OBJECTIVE: To evaluate outcomes of different oral P2Y12 inhibitors in PCI patients. METHODS: We retrospectively studied patients treated between July 1, 2010, and December 31, 2013. Patients received clopidogrel, prasugrel, ticagrelor, or more than 1 antiplatelet (switch) during PCI...
April 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/28438032/influence-of-drying-methods-on-chemical-compositions-antioxidant-and-antibacterial-activity-of-essential-oil-from-lemon-peel
#4
Liang-Liang Zhang, Shuang Lv, Jian-Guo Xu, Li-Fang Zhang
The influence of natural, hot-air and infrared drying on chemical composition and bioactivity of lemon peel essential oil are investigated in this study. The results showed that drying resulted in losses or increases of some components or production of some new substances, but the d-limonene (59.52-70.01%) was found as the main component of essential oil. Drying brought about decreases in the yield, antioxidant and antibacterial activity of essential oil. However, the natural drying had little effect, while the hot-air and infrared drying resulted in significant decreases in these parameters, especially at the higher temperature...
April 24, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28420164/the-angiogenesis-inhibitor-als-l1023-from-lemon-balm-leaves-attenuates-high-fat-diet-induced-nonalcoholic-fatty-liver-disease-through-regulating-the-visceral-adipose-tissue-function
#5
Jeongjun Kim, Haerim Lee, Jonghoon Lim, Jaeho Oh, Soon Shik Shin, Michung Yoon
Similar to neoplastic tissues, growth and development of adipose tissue are thought to be angiogenesis-dependent. Since visceral adipose tissue (VAT) is associated with development and progression of nonalcoholic fatty liver disease (NAFLD), we hypothesized that angiogenesis inhibition would attenuate obesity-induced NAFLD. We fed C57BL/6J mice a low-fat diet (LFD, chow 10% kcal fat), a high-fat diet (HFD, 45% kcal fat) or HFD supplemented with the lemon-balm extract ALS-L1023 (HFD-ALS) for 15 weeks. ALS-L1023 reduced endothelial cell-tube formation in vitro...
April 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28416865/folic-acid-content-and-antioxidant-activity-of-different-types-of-beers-available-in-hungarian-retail
#6
Dániel Koren, Csaba Orbán, Nóra Galló, Szilárd Kun, Beáta Vecseri-Hegyes, Gabriella Kun-Farkas
In this study 40 Hungarian retail beers were evaluated for folic acid content, antioxidant profile and physicochemical parameters. The physicochemical parameters, folic acid content and antioxidant activity of alcohol-free beers were the lowest. Folic acid content of beers aged with sour cherries showed high values, more than 0.4 mg/l and an alcohol-free beer-based mixed drink made with lemon juice contained more than 0.2 mg/l of folic acid. Dark beers and beers aged with sour cherries had the highest antioxidant activity probably owing to their high extract content, components released from the fruits and special malts...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28416860/characterization-of-phenolic-profile-and-antioxidant-capacity-of-different-fruit-part-from-lemon-citrus-limon-burm-cultivars
#7
Wanpeng Xi, Juanfang Lu, Junping Qun, Bining Jiao
Phenolic composition and antioxidant capacity of different fruit part including peel, pulp, juice, whole fruit and seed from five lemon cultivars (Feiminailao, Cuningmeng Limeng, Pangdelusaningmeng, Beijingningmeng) were investigated. Caffeic acid (9.31-741.4 μg/g FW) and chlorogenic acid (2.7-527.5 μg/g FW) were the dominant phenolic acid in fruit tested, Pangdelusaningmeng (PD) and Limeng peels with the highest contents, respectively. Hesperidin was the predominant flavanone (10.27-3315 μg/g FW), Cuningmeng (CN) peels with the highest level...
April 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28415437/a-simplistic-approach-to-green-future-with-eco-friendly-luminescent-carbon-dots-and-their-application-to-fluorescent-nano-sensor-turn-off-probe-for-selective-sensing-of-copper-ions
#8
Poushali Das, Sayan Ganguly, Madhuparna Bose, Subhadip Mondal, Amit Kumar Das, Susanta Banerjee, Narayan Chandra Das
Zero-dimensional fluorescent nanoparticles having specificity as molecular probe appears to be strategically balanced fluorescent nano-probes. In this work, purified lemon extract and l-arginine have been thermally coupled for the extremely acute detection of Cu(2+) in aqueous medium. The Cu(2+) ions may be captured by the amino groups on the surface of the nano-sensor to form cupric ammine complex resulting in quenched fluorescence via an inner filter effect. Our proposed nano-probe is N-doped carbon dots (NCDs) which are efficiently selective as fluorescent chemosensor due to enormous binding affinity towards Cu(2+) in a wide range of concentration (0...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28415385/antitubercular-activity-of-zno-nanoparticles-prepared-by-solution-combustion-synthesis-using-lemon-juice-as-bio-fuel
#9
Prashanth Gopala Krishna, Prashanth Paduvarahalli Ananthaswamy, Priyanka Trivedi, Vinita Chaturvedi, Nagabhushana Bhangi Mutta, Ananda Sannaiah, Amani Erra, Tejabhiram Yadavalli
In this study, we report the synthesis, structural and morphological characteristics of zinc oxide (ZnO) nanoparticles using solution combustion synthesis method where lemon juice was used as the fuel. In vitro anti-tubercular activity of the synthesized ZnO nanoparticles and their biocompatibility studies, both in vitro and in vivo were carried out. The synthesized nanoparticles showed inhibition of Mycobacterium tuberculosis H37Ra strain at concentrations as low as 12.5μg/mL. In vitro cytotoxicity study performed with normal mammalian cells (L929, 3T3-L1) showed that ZnO nanoparticles are non-toxic with a Selectivity Index (SI) >10...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28407917/comprehensive-comparative-analysis-of-volatile-compounds-in-citrus-fruits-of-different-species
#10
Haipeng Zhang, Yunxia Xie, Cuihua Liu, Shilin Chen, Shuangshuang Hu, Zongzhou Xie, Xiuxin Deng, Juan Xu
The volatile profiles of fruit peels and juice sacs from 108 citrus accessions representing seven species were analyzed. Using GC-MS 162 and 107 compounds were determined in the peels and juice sacs, respectively. In the peels, monoterpene alcohols were accumulated in loose-skin mandarins; clementine tangerines and papedas were rich in sesquiterpene alcohols, sesquiterpenes, monoterpene alcohols and monoterpene aldehydes. β-pinene and sabinene were specifically accumulated in 4 of 5 lemon germplasms. Furthermore, concentrations of 34 distinctive compounds were selected to best represent the volatile profiles of seven species for HCA analysis, and the clustering results were in agreement with classic citrus taxonomy...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28400049/species-co-occurrence-affects-the-trophic-interactions-of-two-juvenile-reef-shark-species-in-tropical-lagoon-nurseries-in-moorea-french%C3%A2-polynesia
#11
Philip Matich, Jeremy J Kiszka, Johann Mourier, Serge Planes, Michael R Heithaus
Food web structure is shaped by interactions within and across trophic levels. As such, understanding how the presence and absence of predators, prey, and competitors affect species foraging patterns is important for predicting the consequences of changes in species abundances, distributions, and behaviors. Here, we used plasma δ(13)C and δ(15)N values from juvenile blacktip reef sharks (Carcharhinus melanopterus) and juvenile sicklefin lemon sharks (Negaprion acutidens) to investigate how species co-occurrence affects their trophic interactions in littoral waters of Moorea, French Polynesia...
March 28, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28397014/geraniol-attenuates-4nqo-induced-tongue-carcinogenesis-through-downregulating-the-activation-of-nf-%C3%AE%C2%BAb-in-rats
#12
Arumugam Madankumar, Sasivarnam Tamilarasi, Thandavamoorthy Premkumar, Mani Gopikrishnan, Natesh Nagabhishek, Thiruvengadam Devaki
Geraniol, an acyclic monoterpene found in lemon grass and aromatic herb oil, has been shown to exert antitumor and antioxidant activities against various cancer types. The objective of this study was to investigate the potential chemoprotective role of geraniol against 4-nitroquinoline-1-oxide (4NQO)-induced oral carcinogenesis in male Wistar rats and furthermore to study anti-inflammatory mechanisms of action through possible NF-κB signaling. 4NQO was administered to rats at the dose of 50 ppm through drinking water to induce tongue cancer in 20 weeks...
April 10, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28393526/identification-of-ginger-zingiber-officinale-roscoe-volatiles-and-localization-of-aroma-active-constituents-by-gc-olfactometry
#13
Xueli Pang, Jianmin Cao, Dabin Wang, Jun Qiu, Fanyu Kong
For the characterization of chemical components contributing to the aroma of ginger, which could benefit the development of deep-processed ginger products, volatile extracts were isolated by a combination of direct solvent extraction-solvent-assisted flavor evaporation and static headspace analysis. Aroma-impact components were identified by gas chromatography-olfactometry-mass spectrometry, and the most potent odorants were further screened by aroma extract dilution analysis (AEDA) and static headspace dilution analysis (SHDA)...
April 10, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28380706/practical-care-support-during-the-early-recovery-period-after-acute-coronary-syndrome
#14
Alexandra M Hajduk, Jacquelyn E Hyde, Molly E Waring, Darleen M Lessard, David D McManus, Elizabeth B Fauth, Stephenie C Lemon, Jane S Saczynski
OBJECTIVE: To describe the prevalence and predictors of receipt of practical support among acute coronary syndrome (ACS) survivors during the early post-discharge period. METHOD: 406 ACS patients were interviewed about receipt of practical (instrumental and informational) support during the week after discharge. Demographic, clinical, functional, and psychosocial predictors of instrumental and informational practical support were examined. RESULTS: 81% of participants reported receiving practical support during the early post-discharge period: 75% reported receipt of instrumental support and 51% reported receipt of informational support...
December 1, 2016: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/28369977/biogenic-amine-formation-and-microbiological-quality-of-anchovy-engraulis-encrasicolus-treated-with-lavender-and-lemon-balm-ethanol-extracts
#15
Fatih Özogul, Rana Öztekin, Piotr Kulawik
Biogenic amine formation and bacterial growth of vacuum-packed European anchovy treated with 1% lemon balm (LB) or lavender (LD) ethanol extracts was investigated. The treated samples were stored at 2 ± 1 °C for 11 d and analyzed for biogenic amines, total viable count, fecal coliform count, and lactic acid bacterial count. The analyses were done on 0, 4, 7, 9, and 11 d of storage. Both LB and LD extracts proved effective in reducing most biogenic amines, with histamine reduced by 3-fold compared to control...
April 3, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28367927/beneficial-effects-of-lemon-balm-leaf-extract-on-in-vitro-glycation-of-proteins-arterial-stiffness-and-skin-elasticity-in-healthy-adults
#16
Shintaro Yui, Suzuka Fujiwara, Katsuhisa Harada, Mahoko Motoike-Hamura, Masashi Sakai, Satoshi Matsubara, Kouji Miyazaki
Glycation, a non-enzymatic glycosylation of proteins, induces tissue damage in association with various diseases and aging phenomena. Pentosidine, an advanced glycation end product, is involved in aging phenomena such as tissue stiffness. In this study, we aimed to find a potent anti-glycation food material and to verify its health benefits by clinical trial. From among 681 hot water plant extracts, lemon balm (Melissa officinalis; LB) leaf extract was selected and revealed to have more potent inhibitory activity for pentosidine formation than a representative anti-glycation agent, aminoguanidine...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/28359944/dietary-dehydrated-lemon-peel-improves-the-immune-but-not-the-antioxidant-status-of-gilthead-seabream-sparus-aurata-l
#17
José María García Beltrán, Cristóbal Espinosa, Francisco A Guardiola, M Ángeles Esteban
Lemon (Citrus limon) is the third most important species of citrus in the world, while Spain is the major producer in Europe. Numerous beneficial effects of lemon are known, which explains their use in traditional medicine. The paper describes the effect of dietary dehydrated lemon peel (a sub-product of the lemon industry) on the growth, immune and antioxidant status of gilthead seabream (Sparus aurata L.) over a period of 30 days. Fish fed diets enriched with dehydrated lemon peel (1.5% and 3%) for 15 days showed improved growth and both humoral (seric immunoglobulin M) and cellular (peroxidase activity and phagocytic ability of head kidney leucocytes) immunity, as well as the expression of some immune-related genes (nkefa, il1β, igth and csfr1)...
May 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28355995/new-advances-in-infant-feeding-new-products-and-novel-technologies
#18
M C Pina-Pérez, A Martínez, D Rodrigo
BACKGROUND: Breastfeeding is the best way to provide ideal food for infants. However, there are many situations in which breastfeeding is unviable (maternal illness, hygiene problems, intravenous feeding requirement, storage). Safe, efficient, and nutritious products should be offered by the industry to mothers and healthcare professionals as an alternative. OBJECTIVE: The present review aims to update the state of the art regarding the most innovative developments in infant feeding formulation and, the promising novel technologies that are being investigated to achieve a balance between the microbiological stability, organoleptic and nutritional value of babyfood...
March 28, 2017: Recent Patents on Food, Nutrition & Agriculture
https://www.readbyqxmd.com/read/28338527/a-slight-smell-of-lemon%C3%A2-a-case-report
#19
Catherine Feliu, Yoann Cazaubon, Aurélie Fouley, Hélène Guillemin, Claire Gozalo, Zoubir Djerada
We present here an example of urine substituted with a yellow cleaning product that leads us to develop the main risks to consider in urine toxicology analysis, i.e., adulteration and analytical interferences, and how to deal with them. This grand round highlights the importance of the dialogue between the clinician and a TDM consultant for optimal care of the patient.
March 23, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28330169/investigating-the-effect-of-drought-stress-on-expression-of-wrky1-and-erebp1-genes-and-antioxidant-enzyme-activities-in-lemon-balm-melissa-officinalis-l
#20
Mehdi Rahimi, Mojtaba Kordrostami, Mahmood Maleki, Mohsen ModaresKia
Drought stress is a severe environmental constraint to plant productivity. In this study, gene expression of WRKY1 and EREBP1 genes and activity of two enzymes were investigated in two genotypes, G9 (as resistance) and G12 (as susceptible) of 10 days-old lemon balm seedlings. Experiments were done according to factorial design on the base of completely randomized design with three replications for expression analysis and enzyme assays. Seedlings were cultured in MS medium suspensions, including 0, 3, 6, 12 and 15 % w/v PEG 6000...
June 2016: 3 Biotech
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