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Hematopoietic stem cell transplant

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https://www.readbyqxmd.com/read/29933311/longitudinal-analysis-of-the-relationships-between-social-support-and-health-related-quality-of-life-in-hematopoietic-stem-cell-transplant-recipients
#1
Yongchun Liang, Haifang Wang, Meie Niu, Xiaming Zhu, Jianzheng Cai, Xiubei Wang
BACKGROUND: The correlation between social support and health-related quality of life (HRQOL) has been well documented, but whether social support changes or whether social support consistently plays a significant role in the various phases of the treatment process remains unknown among hematopoietic stem cell transplantation (HSCT) patients. OBJECTIVES: The aims of this study were to assess the changing trends of HRQOL and social support and evaluate the relationship between HRQOL and social support before and after transplantation...
June 22, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29933074/dysfunctional-bone-marrow-mesenchymal-stem-cells-in-patients-with-poor-graft-function-after-allogeneic-hematopoietic-stem-cell-transplantation
#2
Yang Song, Hong-Yan Zhao, Zhong-Shi Lyu, Xie-Na Cao, Min-Min Shi, Qi- Wen, Fei-Fei Tang, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang, Yuan Kong
Poor graft function (PGF) is a life-threatening complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT) and is characterized by defective hematopoiesis. Mesenchymal stem cells (MSCs) have been shown to support hematopoiesis, but little is known about the role of MSCs in the pathogenesis of PGF. In the current prospective case-control study, we evaluated whether the number and function of bone marrow (BM) MSCs in PGF patients differed from those in good graft function (GGF) patients. We found that BM MSCs from PGF patients expanded more slowly and appeared flattened and larger, exhibiting more apoptosis and senescence than MSCs from GGF patients...
June 19, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29933069/outcomes-of-measurable-residual-disease-in-pediatric-acute-myeloid-leukemia-pre-and-post-hematopoietic-stem-cell-transplant-validation-of-difference-from-normal-flow-cytometry-with-chimerism-studies-and-wilms-tumor-1-gene-expression
#3
David A Jacobsohn, Michael R Loken, Mingwei Fei, Alexia Adams, Lisa Eidenschink Brodersen, Brent R Logan, Kwang Woo Ahn, Bronwen E Shaw, Morris Kletzel, Marie Olszewski, Sana Khan, Soheil Meshinchi, Amy Keating, Andrew Harris, Pierre Teira, Reggie E Duerst, Steven P Margossian, Paul L Martin, Aleksandra Petrovic, Christopher C Dvorak, Eneida R Nemecek, Michael W Boyer, Allen R Chen, Jeffrey H Davis, Shalini Shenoy, Sureyya Savasan, Michelle P Hudspeth, Roberta H Adams, Victor A Lewis, Albert Kheradpour, Kimberly A Kasow, Alfred P Gillio, Ann E Haight, Monica Bhatia, Barbara J Bambach, Hilary L Haines, Troy C Quigg, Robert J Greiner, Julie-An Talano, David C Delgado, Alexandra Cheerva, Madhu Gowda, Sanjay Ahuja, Mehmet Ozkaynak, David Mitchell, Kirk R Schultz, Terry J Fry, David M Loeb, Michael A Pulsipher
We enrolled 150 patients in a prospective multi-center study of children with acute myeloid leukemia undergoing hematopoietic stem cell transplant (HSCT) comparing detection of measurable residual (MRD) disease by a "Difference from Normal" flow cytometry (ΔN) approach with assessment of Wilms tumor 1 (WT-1) gene expression without access to the diagnostic specimen. Prospective analysis of the specimens using this approach showed that 23% of patients being screened for HSCT had detectable residual disease by ΔN (0...
June 19, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29933067/long-term-functional-outcomes-following-hematopoietic-stem-cell-transplant-for-early-infantile-krabbe-disease
#4
Heather Allewelt, Mahsa Taskindoust, Jesse Troy, Kristin Page, Susan Wood, Suhag Parikh, Vinod K Prasad, Joanne Kurtzberg
Allogeneic hematopoietic stem cell transplantation (HSCT) can retard the progression of early infantile Krabbe disease (EIKD). Superior outcomes are achieved if HSCT is performed prior to the onset of symptoms, however little information is available about the long-term outcomes in surviving patients. We now describe functional outcomes in pre-symptomatic infants who underwent HSCT for EIKD at ≤2 months of life. Records of the 19 patients who underwent HSCT for EIKD at ≤2 months of age from 1996-2010 were reviewed...
June 19, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29932942/ccr5-revisited-how-mechanisms-of-hiv-entry-govern-aids-pathogenesis
#5
REVIEW
Anne Brelot, Lisa A Chakrabarti
The chemokine receptor CCR5 has been the focus of intensive studies since its role as a coreceptor for HIV entry was discovered in 1996. These studies lead to the development of small molecular drugs targeting CCR5, with maraviroc becoming in 2007 the first clinically approved chemokine receptor inhibitor. More recently, the apparent HIV cure in a patient transplanted with hematopoietic stem cells devoid of functional CCR5 rekindled the interest for inactivating CCR5 through gene therapy and pharmacological approaches...
June 19, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29932285/upfront-eltrombopag-monotherapy-induces-stable-hematologic-remission-in-pediatric-patients-with-nonsevere-idiopathic-aplastic-anemia
#6
Wenliang Geng, Susan Kearney, Stephen Nelson
Aplastic anemia (AA) is characterized by multilineage cytopenias and bone marrow hypocellularity. Severe AA can be treated with immunosuppressive therapy (IST) and/or allogeneic hematopoietic stem cell transplantation. The thrombopoietin agonist eltrombopag has been shown to induce hematopoietic recovery and transfusion independence in adults with refractory and relapsed AA. Recently, upfront eltrombopag therapy in patients with AA in combination with IST has shown efficacy. Data for its use without concurrent IST in pediatric patients with AA remain sparse...
June 22, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29930767/increased-circulating-cd4-foxp3-t-cells-associate-with-early-relapse-following-autologous-hematopoietic-stem-cell-transplantation-in-multiple-myeloma-patients
#7
Egor V Batorov, Marina A Tikhonova, Natalia V Pronkina, Irina V Kryuchkova, Vera V Sergeevicheva, Svetlana A Sizikova, Galina Y Ushakova, Tatiana A Aristova, Dariya S Batorova, Elena V Menyaeva, Andrey V Gilevich, Ekaterina Y Shevela, Alexander A Ostanin, Elena R Chernykh
We investigated dynamics of CD4+ FOXP3+ T cell recovery following the high-dose chemotherapy (HDC) with autologous hematopoietic stem cell transplantation (auto-HSCT) in multiple myeloma (MM) patients. Circulating CD4+ FOXP3+ T cells of 79 MM patients were evaluated using flow cytometry before HDC with auto-HSCT, at the day of engraftment, and following 6 and 12 months. Percentage of CD4+ FOXP3+ T cells restored rapidly following auto-HSCT, became higher than pre-transplant level at the day of engraftment and then subsequently decreased for a year...
June 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29930241/t-cell-replete-haploidentical-peripheral-blood-hematopoietic-cell-transplantation-for-treatment-of-t-lymphoblastic-lymphoma
#8
Lixun Guan, Xiaohong Li, Huaping Wei, Zhenyang Gu, Shasha Zhao, Chengying Zhu, Nan Yang, Feiyan Wang, Lan Luo, Zhe Gao, Wenrong Huang, Honghua Li, Quanshun Wang, Daihong Liu, Xiaoxiong Wu, Chunji Gao
BACKGROUND There is currently little information on haploidentical hematopoietic cell transplantation (haplo-HCT) for T-lymphoblastic lymphoma (T-LBL). Data about peripheral blood stem cells (PBSC) as a reliable graft source for T-LBL treatment are lacking. MATERIAL AND METHODS T-LBL patients who underwent T cell-replete haploidentical peripheral blood hematopoietic cell transplantation (haplo-PBHCT) from July 2007 to January 2017 were retrospectively evaluated. RESULTS A total of 25 patients (age ≥15 years) with median age of 24 (range 15-51) years were enrolled...
June 22, 2018: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29928848/retrospective-evaluation-of-fidaxomicin-versus-oral-vancomycin-for-treatment-of-clostridium-difficile-infections-in-allogeneic-stem-cell-transplant
#9
Laura Prohaska, Zahra Mahmoudjafari, Leyla Shune, Anurag Singh, Tara Lin, Sunil Abhyankar, Siddhartha Ganguly, Dennis Grauer, Joseph McGuirk, Lisa Clough
OBJECTIVE/BACKGROUND: Clostridium difficile infection (CDI) is a potential complication during hematopoietic stem cell transplantation (HSCT), and no specific recommendations exist regarding treatment of CDI in allogeneic SCT patients. Use of metronidazole and oral vancomycin has been associated with clinical failure. Fidaxomicin has previously been found noninferior to the use of oral vancomycin for the treatment of CDI, and no studies have compared the use of oral vancomycin with fidaxomicin for the treatment of CDI in allogeneic SCT...
June 18, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29927482/patient-selection-and-timing-of-allogeneic-hematopoietic-stem-cell-transplantation-for-relapsed-follicular-lymphoma
#10
Mike Fillon
No abstract text is available yet for this article.
June 21, 2018: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29926815/neurological-complications-of-hematopoietic-cell-transplantation-in-children-and-adults
#11
REVIEW
Adriana Octaviana Dulamea, Ioana Gabriela Lupescu
Hematopoietic cell transplantation (HCT) is widely performed for neoplastic and non-neoplastic diseases. HCT involves intravenous infusion of hematopoietic progenitor cells from human leukocyte antigen (HLA)-matched donor (allogeneic) or from the patient (autologous). Before HCT, the patient is prepared with high dose chemotherapy and/or radiotherapy to destroy residual malignant cells and to reduce immunologic resistance. After HCT, chemotherapy is used to prevent graft rejection and graft versus host disease (GvHD)...
June 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29925839/mir-143-145-differentially-regulate-hematopoietic-stem-and-progenitor-activity-through-suppression-of-canonical-tgf%C3%AE-signaling
#12
Jeffrey Lam, Marion van den Bosch, Joanna Wegrzyn, Jeremy Parker, Rawa Ibrahim, Kate Slowski, Linda Chang, Sergio Martinez-Høyer, Gianluigi Condorelli, Mark Boldin, Yu Deng, Patricia Umlandt, Megan Fuller, Aly Karsan
Expression of miR-143 and miR-145 is reduced in hematopoietic stem/progenitor cells (HSPCs) of myelodysplastic syndrome patients with a deletion in the long arm of chromosome 5. Here we show that mice lacking miR-143/145 have impaired HSPC activity with depletion of functional hematopoietic stem cells (HSCs), but activation of progenitor cells (HPCs). We identify components of the transforming growth factor β (TGFβ) pathway as key targets of miR-143/145. Enforced expression of the TGFβ adaptor protein and miR-145 target, Disabled-2 (DAB2), recapitulates the HSC defect seen in miR-143/145-/- mice...
June 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29923335/cecum-perforation-induced-by-mycophenolate-mofetil-after-hematopoietic-stem-cell-transplantation-a-case-report-and-review-of-literature
#13
Barbaros Sahin Karagun, Tugana Akbas, Taner Arpaci, Bulent Antmen
GI perforation after stem cell transplantation is extremely rare and is associated with poor prognosis. In addition, the clinical limitations of MMF are associated with GI intolerance and hematologic suppression. However, the exact mechanism whereby MMF induces changes in GI mucosa is unknown. Currently, there is no definite method to distinguish between GI toxicity associated with MMF and GVHD. It is important to recognize association between MMF and the histologic changes mimicking GVHD, given that GVHD is a significant differential diagnosis in stem cell transplant patients...
June 19, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29923253/comparison-of-survival-outcome-between-donor-types-or-stem-cell-sources-for-childhood-acute-myeloid-leukemia-after-allogenic-hematopoietic-stem-cell-transplantation-a-multicenter-retrospective-study-of-study-alliance-of-yeungnam-pediatric-hematology-oncology
#14
Ye Jee Shim, Jae Min Lee, Heung Sik Kim, Nani Jung, Young Tak Lim, Eu Jeen Yang, Jeong Ok Hah, Young-Ho Lee, Hee Won Chueh, Jae Young Lim, Eun Sil Park, Jeong A Park, Ji Kyoung Park, Sang Kyu Park
We compared transplant outcomes between donor types and stem cell sources for childhood acute myeloid leukemia (AML). The medical records of children with AML in the Yeungnam region of Korea from January 2000 to June 2017 were reviewed. In all, 76 children with AML (male-to-female ratio = 46:30) received allogenic hematopoietic stem cell transplantation (allo-HSCT). In total, 29 patients received HSCT from either a matched-related donor or a mismatched-related donor, 32 patients received an unrelated donor, and 15 patients received umbilical cord blood...
June 19, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29923123/impact-of-hospital-length-of-stay-on-the-risk-of-readmission-and-overall-survival-after-allogeneic-stem-cell-transplantation
#15
Aika Seto, Yoshiko Atsuta, Naomi Kawashima, Yukiyasu Ozawa, Koichi Miyamura, Hitoshi Kiyoi
Patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) are at high risk of readmission for complications. We sought to examine the association between HSCT hospital length of stay and the incidence of readmission and survival after discharge. We retrospectively reviewed the cases of 230 allo-HSCT recipients. The cumulative incidence of readmission with non-relapse transplant-related complications (including infections; acute and chronic GVHD; liver, lung, renal, or neurological complications; and haematological abnormalities) 2 years after the first discharge was 49...
June 19, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29922491/immunological-emergency-in-neonate-case-report-and-role-of-early-screening
#16
Veronica Mugarab Samedi, Amy Shafey, Essa Al Awad, Luis Murguia Favela
Healthy looking newborns may have severe combined immunodeficiency (SCID), and neonatologists frequently are the first physicians to encounter these patients. Physicians usually have a high index of suspicion for this condition in presence of certain risk factors (unexplained infants' deaths, consanguinity); however, >80% of infants with SCID have no positive family history. A timely diagnosis of this condition is crucial in decreasing both mortality and morbidity. The only way to detect SCID prior to the onset of infections is newborn screening (NBS)...
April 2018: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/29922299/the-emerging-link-between-the-complement-cascade-and-purinergic-signaling-in-stress-hematopoiesis
#17
REVIEW
Mariusz Z Ratajczak, Mateusz Adamiak, Magda Kucia, William Tse, Janina Ratajczak, Wieslaw Wiktor-Jedrzejczak
Innate immunity plays an important role in orchestrating the immune response, and the complement cascade (ComC) is a major component of this ancient defense system, which is activated by the classical-, alternative-, or mannan-binding lectin (MBL) pathways. However, the MBL-dependent ComC-activation pathway has been somewhat underappreciated for many years; recent evidence indicates that it plays a crucial role in regulating the trafficking of hematopoietic stem/progenitor cells (HSPCs) by promoting their egress from bone marrow (BM) into peripheral blood (PB)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29921408/treatment-of-symptomatic-oral-mucositis-with-sodium-hyaluronate-and-synthetic-amino-acid-precursors-of-collagen-in-patients-undergoing-haematopoietic-stem-cell-transplantation
#18
T Ruggiero, R Pol, D Camisassa, S Simiele, L Giaccone, S Carossa
The purpose of the study is to evaluate the clinical effects of Mucosamin® (a spray preparation containing sodium hyaluronate combined with a pool of amino acids of precursor collagen, including L-Proline, L-Leucine, L-Lysine and glycine) on wound healing and pain management of oral mucositis after hematopoietic stem cell transplantation. The importance of professional dental hygiene by dental hygienist in reducing the severity of oral mucositis as unique therapy or in addition to therapy with Mucosamin® was also evaluated...
May 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29921011/selective-t-cell-depleted-haploidentical-hematopoietic-stem-cell-transplantation-for-relapsed-refractory-neuroblastoma
#19
Anthony P Y Liu, Pamela P W Lee, Janette S Y Kwok, Rock Y Y Leung, Alan K S Chiang, Shau-Yin Ha, Daniel K L Cheuk, Godfrey C F Chan
Relapsed/refractory NB carries a bleak outcome, warranting novel treatment options. HaploHSCT induces a graft-versus-NB effect via natural killer cell alloreactivity. Review of patients with relapsed/refractory NB who underwent haploHSCT with ex vivo T-cell depletion in our unit from 2013 through 2018. Ten patients were identified (male=5; median age at haploHSCT=6.45 y, range: 3.49-11.02 y). Indications were relapsed in 7 and refractoriness in 3; disease status at haploHSCT was CR in 2, PR in 6, and PD in 2...
June 19, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29920973/the-hla-b-54-35-and-b-54-38-identified-in-volunteer-donors-for-hematopoietic-stem-cell-transplant
#20
I-C Baek, E-J Choi, D-H Shin, H-J Kim, T-G Kim
HLA-B*54:35 and -B*54:38 differ from HLA-B*54:01:01 in codons in exons 2 and 3 This article is protected by copyright. All rights reserved.
June 19, 2018: HLA
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