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https://www.readbyqxmd.com/read/24127015/hemophagocytic-lymphohistiocytosis-critical-reappraisal-of-a-potentially-under-recognized-condition
#1
Somanath Padhi, Renu G' Boy Varghese, Anita Ramdas, Manjiri Dilip Phansalkar, RajLaxmi Sarangi
Hemophagocytic lymphohistiocytosis (HLH) is an uncommon, potentially life threatening, hyper inflammatory syndrome of diverse etiologies. Cardinal signs include prolonged fever, organomegaly, and persistent unexplained cytopenias. In spite of the well known diagnostic criteria put forth by HLH society, this continues to pose great diagnostic challenge in both pediatric and adult intensive care settings. We describe 4 adult (2 males, 2 females, aged 19, 29, 40, and 17 years) and 3 pediatric (2 males, 1 female, aged 1 month, 6 months, and 12 years) patients with secondary HLH who satisfied the HLH-2004 diagnostic criteria...
December 2013: Frontiers of Medicine
https://www.readbyqxmd.com/read/23029848/hypopituitarism-following-poisonous-viperbite
#2
Sanjay Kumar Bandyopadhyay, Ranjana Bandyopadhyay, Anita Dutta, Salil Kumar Pal
A 28 years old male had the history of viperbite 3 years back. He has treated in a nearby rural hospital with snake venom antiserum along with other supportive therapy. He responded and discharged from hospital within a week. Three years later he had history of fever, drowsiness which progressed to unconsciousness. On examination he was found to have scanty body hairs, smooth, shiny skin with superficial oral ulcers. Serum hormone estimation confirmed the deficiency of gonadotrophins, thyrotrophin and corticotrophin while growth hormone failed to rise >3ng/ml after insulin intolerance test...
February 2012: Journal of the Indian Medical Association
https://www.readbyqxmd.com/read/8670005/guillain-barr%C3%A3-syndrome-an-unusual-complication-after-snake-bite
#3
T Y Chuang, S W Lin, R C Chan
The mortality rate of the Formosan krait bite has been reported to be 23%; death is from respiratory paralysis caused by neuromuscular junctions being blocked by bungarotoxin. This article presents the first case report of Guillain-Barré syndrome after snake envenomization. The patient presented with symmetric paresis and sensory signs in the upper and lower limbs, autonomic dysfunction, facial nerve involvement, and mild elevated cerebrospinal fluid protein at about 4 weeks after the bite. Electrodiagnostic studies revealed profound sensory and motor polyneuropathy...
July 1996: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/2292459/formosanin-c-an-immunomodulator-with-antitumor-activity
#4
R T Wu, H C Chiang, W C Fu, K Y Chien, Y M Chung, L Y Horng
Paris formosana Hayata (Liliaceae) grown in the mountain areas of Taiwan, has been used as a folk remedy for snake bite, and as an anti-inflammatory or anti-neoplastic agent. The effects of formosanin-C, a diosgenin saponin isolated from Paris formosana, on immune responses and transplantable murine tumor were studied. In culture systems, formosanin-C (0.03-0.16 microM) displayed significant enhancement of the blastogenic response of human peripheral blood cells to phytohemagglutinin. Formosanin-C also significantly increased the 3H-thymidine incorporation of ConA-stimulated lymphocytes at concentrations of 0...
1990: International Journal of Immunopharmacology
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